WO1999066051A3 - Nek-related and bub1-related protein kinases - Google Patents

Nek-related and bub1-related protein kinases Download PDF

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Publication number
WO1999066051A3
WO1999066051A3 PCT/US1999/013533 US9913533W WO9966051A3 WO 1999066051 A3 WO1999066051 A3 WO 1999066051A3 US 9913533 W US9913533 W US 9913533W WO 9966051 A3 WO9966051 A3 WO 9966051A3
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WO
WIPO (PCT)
Prior art keywords
nek
bub1
kinase
identified
protein kinases
Prior art date
Application number
PCT/US1999/013533
Other languages
French (fr)
Other versions
WO1999066051A2 (en
Inventor
Gregory Plowman
Ricardo Martinez
Yingfang Zhu
Original Assignee
Sugen Inc
Gregory Plowman
Ricardo Martinez
Yingfang Zhu
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Sugen Inc, Gregory Plowman, Ricardo Martinez, Yingfang Zhu filed Critical Sugen Inc
Priority to CA002331889A priority Critical patent/CA2331889A1/en
Priority to JP2000554860A priority patent/JP2002518016A/en
Priority to EP99930298A priority patent/EP1088079A2/en
Priority to AU46862/99A priority patent/AU4686299A/en
Publication of WO1999066051A2 publication Critical patent/WO1999066051A2/en
Publication of WO1999066051A3 publication Critical patent/WO1999066051A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/12—Transferases (2.) transferring phosphorus containing groups, e.g. kinases (2.7)
    • C12N9/1205—Phosphotransferases with an alcohol group as acceptor (2.7.1), e.g. protein kinases
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Biomedical Technology (AREA)
  • Molecular Biology (AREA)
  • Wood Science & Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Zoology (AREA)
  • Genetics & Genomics (AREA)
  • Hospice & Palliative Care (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Hematology (AREA)
  • Microbiology (AREA)
  • Psychiatry (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)

Abstract

The present invention relates to BUB1 and NEK kinase polypeptides, nucleotide sequences encoding the kinase polypeptides, as well as various products and methods useful for the diagnosis and treatment of various kinase-related diseases and conditions. Through the use of a targeted PCR cloning strategy, the human BUB1 serine/threonine kinase was identified and its protein structure was predicted. Additionally, through the use of a bioinformatics strategy, three mammalian members of the NEK-subfamily of STK's have been identified and their protein structure predicted.
PCT/US1999/013533 1998-06-16 1999-06-15 Nek-related and bub1-related protein kinases WO1999066051A2 (en)

Priority Applications (4)

Application Number Priority Date Filing Date Title
CA002331889A CA2331889A1 (en) 1998-06-16 1999-06-15 Nek-related and bub1-related protein kinases
JP2000554860A JP2002518016A (en) 1998-06-16 1999-06-15 NEK-related and BUB1-related protein kinases
EP99930298A EP1088079A2 (en) 1998-06-16 1999-06-15 Nek-related and bub1-related protein kinases
AU46862/99A AU4686299A (en) 1998-06-16 1999-06-15 Nek-related and bub1-related protein kinases

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US8952098P 1998-06-16 1998-06-16
US60/089,520 1998-06-16
US9826598P 1998-08-28 1998-08-28
US60/098,265 1998-08-28

Publications (2)

Publication Number Publication Date
WO1999066051A2 WO1999066051A2 (en) 1999-12-23
WO1999066051A3 true WO1999066051A3 (en) 2000-06-15

Family

ID=26780662

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/US1999/013533 WO1999066051A2 (en) 1998-06-16 1999-06-15 Nek-related and bub1-related protein kinases

Country Status (5)

Country Link
EP (1) EP1088079A2 (en)
JP (1) JP2002518016A (en)
AU (1) AU4686299A (en)
CA (1) CA2331889A1 (en)
WO (1) WO1999066051A2 (en)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6183962B1 (en) * 1998-09-09 2001-02-06 Millennium Pharmaceuticals, Inc. Protein kinase molecules and uses therefor
DE10011530A1 (en) * 2000-03-13 2001-09-27 Robert Elez New antisense oligonucleotides that inhibit polo-like kinase, useful for treating tumors that overexpress this kinase, have strong and selective action
AU2001266954A1 (en) * 2000-06-15 2001-12-24 Millennium Pharmaceuticals, Inc. 53070, a novel human protein kinase family member and uses thereof
AU2001273350A1 (en) * 2000-07-11 2002-01-21 Deltagen, Inc. Transgenic mice containing targeted kinase gene disruptions
AU2002214576A1 (en) * 2000-10-13 2002-04-22 The Government Of The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Genes related to development of refractory prostate cancer
US7033790B2 (en) 2001-04-03 2006-04-25 Curagen Corporation Proteins and nucleic acids encoding same
US20040097441A1 (en) * 2002-11-16 2004-05-20 Isis Pharmaceuticals Inc. Modulation of NIMA-related kinase 6 expression
US20060052582A1 (en) * 2002-06-11 2006-03-09 Joan Roig Amores Identification of inhibitors of mitosis
CA2907730A1 (en) * 2013-03-21 2014-09-25 Bayer Pharma Aktiengesellschaft Diaminoheteroaryl substituted indazoles

Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011234A2 (en) * 1996-09-12 1998-03-19 Incyte Pharmaceuticals, Inc. Human protein kinases
WO1998056910A1 (en) * 1997-06-11 1998-12-17 Chiron Corporation DETECTION OF LOSS OF THE WILD-TYPE huBUB1 GENE
WO1999028334A1 (en) * 1997-12-01 1999-06-10 Fox Chase Cancer Center Novel genes encoding proteins involved in mitotic checkpoint control and methods of use thereof
WO1999047638A2 (en) * 1998-03-16 1999-09-23 The Johns Hopkins University School Of Medicine Mutations in mitotic check point genes and methods of diagnosis
WO1999050396A1 (en) * 1998-03-27 1999-10-07 Incyte Pharmaceuticals, Inc. Nek1-related protein kinase
WO1999055865A1 (en) * 1998-04-29 1999-11-04 Genesis Research And Development Corporation Limited Polynucleotides isolated from skin cells and methods for their use
WO2000008178A2 (en) * 1998-08-04 2000-02-17 Immunex Corporation Murine dna molecules encoding polypeptides having kinase functions

Patent Citations (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998011234A2 (en) * 1996-09-12 1998-03-19 Incyte Pharmaceuticals, Inc. Human protein kinases
WO1998056910A1 (en) * 1997-06-11 1998-12-17 Chiron Corporation DETECTION OF LOSS OF THE WILD-TYPE huBUB1 GENE
WO1999028334A1 (en) * 1997-12-01 1999-06-10 Fox Chase Cancer Center Novel genes encoding proteins involved in mitotic checkpoint control and methods of use thereof
WO1999047638A2 (en) * 1998-03-16 1999-09-23 The Johns Hopkins University School Of Medicine Mutations in mitotic check point genes and methods of diagnosis
WO1999050396A1 (en) * 1998-03-27 1999-10-07 Incyte Pharmaceuticals, Inc. Nek1-related protein kinase
WO1999055865A1 (en) * 1998-04-29 1999-11-04 Genesis Research And Development Corporation Limited Polynucleotides isolated from skin cells and methods for their use
WO2000008178A2 (en) * 1998-08-04 2000-02-17 Immunex Corporation Murine dna molecules encoding polypeptides having kinase functions

Non-Patent Citations (15)

* Cited by examiner, † Cited by third party
Title
CAHILL D.P. ET AL.: "Mutations of mitotic checkpoint genes in human cancers", NATURE, vol. 392, 19 March 1998 (1998-03-19), pages 300 - 303, XP002124486 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002110237, Database accession no. AA307961 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124487, Database accession no. AF043294 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124724, Database accession no. AF047471 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002124725, Database accession no. AF053305 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002134061, Database accession no. AA538277 *
DATABASE EMBL NUCLEOTIDE SEQU 1 January 1900 (1900-01-01), XP002134062, Database accession no. AA030068 *
HARDWICK K.G.: "The spindle checkpoint", TRENDS IN GENETICS, NL, ELSEVIER SCIENCE PUBLISHERS B.V. AMSTERDAM, vol. 14, no. 1, January 1998 (1998-01-01), pages 1 - 4, XP004101469, ISSN: 0168-9525 *
ORR-WEAVER T.L. AND WEINBERG R.A.: "A checkpoint on the road to cancer", NATURE, vol. 392, 19 March 1998 (1998-03-19), pages 223 - 224, XP002124726 *
OUYANG B. ET AL.: "Human Bub1: a putative spindle checkpoint kinase closely linked to cell proliferation", CELL GROWTH & DIFFERENTIATION, vol. 9, October 1998 (1998-10-01), pages 877 - 885, XP002084405 *
PANGILINAN F. ET AL.: "Mammalian BUB1 protein kinases: map positions and in vivo expression", GENOMICS, vol. 46, 1997, pages 379-388, XP002084404, ISSN: 0888-7543 *
RHEE K. AND WOLGEMUTH D.J.: "The NIMA-related kinase 2, Nek2, is expressed in specific stages of the meiotic cell cycle and associates with meiotic chromosomes", DEVELOPMENT, GB, COLCHESTER, ESSEX, vol. 124, no. 11, 1997, pages 2167 - 2177, XP002110242, ISSN: 0950-1991 *
SCHULTZ S.J. ET AL.: "Cell cycle-dependent expression of Nek2, a novel human protein kinase related to the NIMA mitotic regulator of Aspergillus nidulans", CELL GROWTH & DIFFERENTIATION, vol. 5, no. 6, June 1994 (1994-06-01), pages 625 - 635, XP002054148 *
STRAIGHT A.F.: "Cell cycle: Checkpoint proteins and kinetochores", CURRENT BIOLOGY, vol. 7, no. 10, 1 October 1997 (1997-10-01), pages R613 - R616, XP000857172 *
TAYLOR S.S. AND MCKEON F.: "Kinetochore localization of murine Bub1 is required for normal mitotic timing and checkpoint response to spindle damage", CELL, vol. 89, 30 May 1997 (1997-05-30), pages 727-735, XP002084401, ISSN: 0092-8674 *

Also Published As

Publication number Publication date
JP2002518016A (en) 2002-06-25
AU4686299A (en) 2000-01-05
EP1088079A2 (en) 2001-04-04
CA2331889A1 (en) 1999-12-23
WO1999066051A2 (en) 1999-12-23

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