BRPI0418326A - método de regeneração de tecidos - Google Patents

método de regeneração de tecidos

Info

Publication number
BRPI0418326A
BRPI0418326A BRPI0418326-6A BRPI0418326A BRPI0418326A BR PI0418326 A BRPI0418326 A BR PI0418326A BR PI0418326 A BRPI0418326 A BR PI0418326A BR PI0418326 A BRPI0418326 A BR PI0418326A
Authority
BR
Brazil
Prior art keywords
epo
liver
tissue
days
composition
Prior art date
Application number
BRPI0418326-6A
Other languages
English (en)
Inventor
Augustinus Bader
Original Assignee
Bionethos Holding Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from EP03029961A external-priority patent/EP1550715A1/de
Priority claimed from DE10361813A external-priority patent/DE10361813A1/de
Application filed by Bionethos Holding Gmbh filed Critical Bionethos Holding Gmbh
Publication of BRPI0418326A publication Critical patent/BRPI0418326A/pt

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/37—Digestive system
    • A61K35/407—Liver; Hepatocytes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/196—Thrombopoietin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/36—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix
    • A61L27/38—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells
    • A61L27/3804—Materials for grafts or prostheses or for coating grafts or prostheses containing ingredients of undetermined constitution or reaction products thereof, e.g. transplant tissue, natural bone, extracellular matrix containing added animal cells characterised by specific cells or progenitors thereof, e.g. fibroblasts, connective tissue cells, kidney cells
    • A—HUMAN NECESSITIES
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    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L27/00—Materials for grafts or prostheses or for coating grafts or prostheses
    • A61L27/50—Materials characterised by their function or physical properties, e.g. injectable or lubricating compositions, shape-memory materials, surface modified materials
    • A61L27/54—Biologically active materials, e.g. therapeutic substances
    • A—HUMAN NECESSITIES
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P19/04—Drugs for skeletal disorders for non-specific disorders of the connective tissue
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
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    • A61P5/14—Drugs for disorders of the endocrine system of the thyroid hormones, e.g. T3, T4
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    • A61P9/14—Vasoprotectives; Antihaemorrhoidals; Drugs for varicose therapy; Capillary stabilisers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61L—METHODS OR APPARATUS FOR STERILISING MATERIALS OR OBJECTS IN GENERAL; DISINFECTION, STERILISATION OR DEODORISATION OF AIR; CHEMICAL ASPECTS OF BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES; MATERIALS FOR BANDAGES, DRESSINGS, ABSORBENT PADS OR SURGICAL ARTICLES
    • A61L2300/00—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices
    • A61L2300/40—Biologically active materials used in bandages, wound dressings, absorbent pads or medical devices characterised by a specific therapeutic activity or mode of action
    • A61L2300/412—Tissue-regenerating or healing or proliferative agents
    • A61L2300/414—Growth factors

Abstract

MéTODO DE REGENERAçãO DE TECIDOS. A presente invenção refere-se ao uso de fatores de crescimento hematopoiéticos, em particular eritropoietina (EPO) e trombopoietina (TPO), ou derivados, análogos ou partes dos mesmos, para promover regeneração estrutural tissular.
BRPI0418326-6A 2003-12-30 2004-12-30 método de regeneração de tecidos BRPI0418326A (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP03029961A EP1550715A1 (de) 2003-12-30 2003-12-30 Verfahren zur Regenation von Gewebe
DE10361813A DE10361813A1 (de) 2003-12-30 2003-12-30 Verfahren zur Regeneration von Gewebe
PCT/EP2004/014839 WO2005063965A1 (de) 2003-12-30 2004-12-30 Verfahren zur regeneration von gewebe

Publications (1)

Publication Number Publication Date
BRPI0418326A true BRPI0418326A (pt) 2007-05-02

Family

ID=34740522

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI0418326-6A BRPI0418326A (pt) 2003-12-30 2004-12-30 método de regeneração de tecidos

Country Status (14)

Country Link
US (2) US7910547B2 (pt)
EP (2) EP1699915B1 (pt)
JP (2) JP4903580B2 (pt)
AT (1) ATE469654T1 (pt)
AU (2) AU2004309083B2 (pt)
BR (1) BRPI0418326A (pt)
CA (1) CA2550301A1 (pt)
DE (1) DE502004011252D1 (pt)
DK (2) DK1699915T3 (pt)
ES (2) ES2606068T3 (pt)
PL (2) PL2233150T3 (pt)
PT (1) PT1699915E (pt)
RU (2) RU2392314C2 (pt)
WO (1) WO2005063965A1 (pt)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026480A1 (de) * 2000-05-29 2001-12-13 Augustinus Bader Verfahren zur Herstellung eines empfängerspezifischen Gewebe-Transplantats oder -Implantats
EP1699915B1 (de) 2003-12-30 2010-06-02 Augustinus Bader Verwendung des erythropoietins zur regeneration von lebergewebe
JP4982841B2 (ja) * 2005-10-12 2012-07-25 国立大学法人名古屋大学 再生医療骨組成物
US20080107632A1 (en) * 2006-09-06 2008-05-08 Henrich Cheng Fibrin glue composition for repairing nerve damage and methods thereof
JP4696247B2 (ja) * 2006-12-11 2011-06-08 国立大学法人 筑波大学 肝線維化抑制剤
JP5098018B2 (ja) * 2007-03-06 2012-12-12 国立大学法人 筑波大学 肝炎治療剤
AR065613A1 (es) * 2007-03-09 2009-06-17 Chugai Pharmaceutical Co Ltd Agentes de proteccion para organos transplantados
EP2018835B1 (de) 2007-07-09 2014-03-05 Augustinus Bader Wirkstoff abgebendes Pflaster
PL2192907T3 (pl) 2007-08-16 2018-10-31 Remedor Biomed Ltd. Kompozycje erytropoetyny i fibronektyny do zastosowań terapeutycznych
WO2009083203A2 (de) * 2007-12-28 2009-07-09 Heraeus Kulzer Gmbh Topische anwendung und formulierung von erythropoietin für die wundheilung der haut
WO2009089324A1 (en) * 2008-01-08 2009-07-16 Yale University Compositions and methods for promoting patency of vascular grafts
US20100310626A1 (en) * 2008-01-24 2010-12-09 Remedor Biomed Ltd. Erythropoietin and fibronectin compositions for bone regeneration
US8470369B2 (en) * 2008-03-10 2013-06-25 Marfly 2, L.P Bone paste composition
JP2011516436A (ja) * 2008-03-31 2011-05-26 バーダー、アウグスティヌス 幹細胞又は骨髄細胞を用いる組織の再生のための方法及び組成物
CA2748147C (en) * 2008-12-24 2017-06-20 Augustinus Bader Rapid preparation and use of engineered tissue and scaffolds as individual implants
US20100272816A1 (en) * 2009-04-27 2010-10-28 Wolfgang Rudinger Microcapsules comprising liver cells and erythropoietin, methods for preparing said microcapsules and methods for treating a patient comprising applying said microcapsules to the patient
JP2013520168A (ja) * 2010-02-22 2013-06-06 プレジデント アンド フェロウズ オブ ハーバード カレッジ 操作された神経支配組織を生成する方法およびその使用
WO2011104707A1 (en) * 2010-02-23 2011-09-01 Remedor Biomed Ltd. Methods and compositions for enhancing fat graft survival
US20130149349A1 (en) 2010-06-03 2013-06-13 Indiana University Research And Technology Corporation Use of compounds with thrombopoietic activity to promote bone growth and healing
EP2590666B1 (en) 2010-07-06 2017-04-26 Augustinus Bader Topical application of erythropoietin for use in the treatment of injuries of the cornea
WO2012031778A1 (de) 2010-09-12 2012-03-15 Augustinus Bader Verwendung von erythropoietin bei der heilung von wunden oder gewebedefekten ohne narbenbildung
WO2012148200A2 (ko) * 2011-04-26 2012-11-01 아주대학교 산학협력단 허혈성 혈관 질환 치료시술 보조용 조성물
US11311367B2 (en) 2012-01-31 2022-04-26 Wake Forest University Health Sciences Tissue-engineered gut-sphincter complexes and methods of making the same
WO2013116446A1 (en) * 2012-01-31 2013-08-08 Wake Forest University Health Sciences Tubular bioengineered smooth muscle structures
US9795965B2 (en) * 2013-01-03 2017-10-24 Brigham And Women's Hospital, Inc. System and method for a biomimetic fluid processing
RU2522816C1 (ru) * 2013-02-12 2014-07-20 Российская Федерация, от имени которой выступает Министерство промышленности и торговли Российской Федерации (Минпромторг России) Композиция для клеточно-заместительной терапии дефектов мягких тканей
CN106414703B (zh) 2014-03-31 2019-10-18 布里格姆女子医院有限公司 仿生流体处理的系统和方法
JP2016067312A (ja) * 2014-09-30 2016-05-09 株式会社ジーシー 軟骨分化培養液、及び軟骨組織
RU2582948C1 (ru) * 2014-10-23 2016-04-27 Ренат Рашитович Ахмеров Способ волюмизации мягких тканей с помощью термически обработанной тромбоцитарной аутологичной плазмы
US10232048B1 (en) * 2014-11-18 2019-03-19 Divine Api-Logics, LLC Apitherapy method and composition
US20180296706A1 (en) * 2015-10-05 2018-10-18 Board Of Regents, The University Of Texas System Micro-and nano-device for cartilage injury detection and treatment
WO2017100782A1 (en) 2015-12-11 2017-06-15 Research Institute At Nationwide Children's Hospital Systems and methods for optimized patent specific tissue engineering vascular grafts
CN108367007A (zh) * 2015-12-16 2018-08-03 第三共株式会社 用于伤口的治疗剂
US20190015190A1 (en) 2015-12-30 2019-01-17 Wake Forest University Health Sciences Tissue-engineered gut-sphincter complexes and methods of making the same
RU2638796C1 (ru) * 2016-08-05 2017-12-15 Общество с ограниченной ответственностью "Покровский банк стволовых клеток" Способ получения двухкомпонентного препарата для лечения повреждения суставов путем малоинвазивного введения в суставную сумку и препарат, полученный этим способом
CN110234311B (zh) 2016-11-10 2022-08-12 Asc瑞珍尼特有限公司 含有促红细胞生成素衍生的分子的用于局部应用的美容制剂
RU2648869C1 (ru) * 2017-04-03 2018-03-28 Анатолий Владимирович Толстов Способ лечения локальных ожоговых ран II-III А степени
RU2650214C1 (ru) * 2017-04-04 2018-04-11 федеральное государственное бюджетное образовательное учреждение высшего образования "Омский государственный медицинский университет" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ОмГМУ Минздрава России) Способ комбинированной остеопластической хирургии околоносовых пазух с использованием фактора роста
RU2666595C1 (ru) * 2017-09-26 2018-09-11 федеральное государственное бюджетное образовательное учреждение высшего образования Кубанский государственный медицинский университет Министерства Здравоохранения Российской Федерации ФГБОУ ВО КубГМУ Минздрава России Гидрогель для коррекции посттрепанационного дефекта черепа
EP3768222A4 (en) * 2018-03-20 2021-12-22 University of Pittsburgh - Of the Commonwealth System of Higher Education Regenerating vital gums
US20210106718A1 (en) * 2019-10-14 2021-04-15 Board Of Regents, The University Of Texas System Mussel inspired nancomposite adhesives for biomedical applications
CN113521049A (zh) * 2021-07-29 2021-10-22 姚雷利 一种妊娠纹脱模修复方法
WO2023168153A1 (en) * 2022-03-03 2023-09-07 Fibrobiologics, Inc. Therapeutic use of fibroblasts to stimulate regeneration and repair of atrophied spleen
WO2023210713A1 (ja) * 2022-04-27 2023-11-02 国立大学法人京都大学 心外膜細胞再生促進剤および心外膜細胞の再生促進方法

Family Cites Families (35)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
NZ210501A (en) 1983-12-13 1991-08-27 Kirin Amgen Inc Erythropoietin produced by procaryotic or eucaryotic expression of an exogenous dna sequence
IL77081A (en) 1984-12-04 1999-10-28 Genetics Inst AND sequence encoding human erythropoietin, a process for its preparation and a pharmacological preparation of human erythropoietin
US4677195A (en) 1985-01-11 1987-06-30 Genetics Institute, Inc. Method for the purification of erythropoietin and erythropoietin compositions
US4954437A (en) 1986-09-15 1990-09-04 Integrated Genetics, Inc. Cell encoding recombinant human erythropoietin
US5716644A (en) * 1992-06-11 1998-02-10 Alkermes, Inc. Composition for sustained release of non-aggregated erythropoietin
US6008047A (en) 1993-04-08 1999-12-28 Livercell L.L.C. Cell culturing method and medium
IL110669A (en) 1993-08-17 2008-11-26 Kirin Amgen Inc Erythropoietin analogs
ATE354377T1 (de) * 1993-12-02 2007-03-15 Max Delbrueck Centrum Antitumormittel, enthaltend ein zytostatikum und ein kontrastmittel
CA2183266A1 (en) 1994-02-14 1995-08-17 Richard D. Holly Hematopoietic protein and materials and methods for making it
WO1995021919A2 (en) 1994-02-14 1995-08-17 Kirin Brewery Company, Limited Protein having tpo activity
CZ288926B6 (cs) 1994-03-31 2001-09-12 Amgen Inc. MGDF derivát, způsob jeho výroby a farmaceutický prostředek s jeho obsahem
US7008634B2 (en) * 1995-03-03 2006-03-07 Massachusetts Institute Of Technology Cell growth substrates with tethered cell growth effector molecules
US5879673A (en) 1996-01-25 1999-03-09 Genentech, Inc. Administration of thrombopoietin on a single day only
US5817343A (en) * 1996-05-14 1998-10-06 Alkermes, Inc. Method for fabricating polymer-based controlled-release devices
RU2115748C1 (ru) * 1996-11-19 1998-07-20 Открытое акционерное общество "АВИСМА титано-магниевый комбинат" Способ переработки отходящих газов магниевого производства
DE59803925D1 (de) 1997-06-27 2002-05-29 Augustinus Bader Bioartifizielles transplantat und verfahren zu seiner herstellung
US6165783A (en) * 1997-10-24 2000-12-26 Neuro Spheres Holdings Ltd. Erythropoietin-mediated neurogenesis
US6776984B1 (en) * 1999-08-20 2004-08-17 George R. Schwartz Induced regeneration and repair of damaged neurons and nerve axon myelin
JO2291B1 (en) 1999-07-02 2005-09-12 اف . هوفمان لاروش ايه جي Erythropoietin derivatives
AU6092900A (en) * 1999-07-14 2001-02-05 Board Of Trustees Of The Leland Stanford Junior University Animals comprising human hepatocellular tissue
US6555374B1 (en) 1999-08-19 2003-04-29 Artecel Sciences, Inc. Multiple mesodermal lineage differentiation potentials for adipose tissue-derived stromal cells and uses thereof
US6479064B1 (en) * 1999-12-29 2002-11-12 Children's Medical Center Corporation Culturing different cell populations on a decellularized natural biostructure for organ reconstruction
US6586398B1 (en) 2000-04-07 2003-07-01 Amgen, Inc. Chemically modified novel erythropoietin stimulating protein compositions and methods
DE10034583A1 (de) 2000-07-14 2002-01-31 Axel Haverich Individuelle Venenklappenprothese
AU2001290312A1 (en) * 2000-10-16 2002-04-29 Chugai Seiyaku Kabushiki Kaisha Peg-modified erythropoietin
DE60144439D1 (de) 2000-12-20 2011-05-26 Hoffmann La Roche Konjugate von erythropoietin (epo) mit polyethylenglykol (peg)
US7767643B2 (en) * 2000-12-29 2010-08-03 The Kenneth S. Warren Institute, Inc. Protection, restoration, and enhancement of erythropoietin-responsive cells, tissues and organs
EP1499190A4 (en) * 2001-05-17 2005-06-15 Univ Illinois METHOD FOR THE TREATMENT OF ILL. DISEASES AND LIVER DAMAGES WITH GROWTH HORMONE AND FOXM1B
EP1406680A4 (en) * 2001-06-15 2007-01-10 Johns Hopkins Singapore Pte Lt BIOFUNCTIONAL FIBERS
DE60239217D1 (de) * 2001-11-16 2011-03-31 Childrens Medical Center Erzeugung gewebetechnologisch hergestellter weiblicher fortpflanzungsorgane
CN101766809A (zh) * 2002-06-20 2010-07-07 奥古斯蒂努斯·巴德 在生长因子和生物基质或载体结构存在下进行细胞增殖和分化的方法和装置
DE10234192B4 (de) * 2002-07-26 2009-11-26 Epoplus Gmbh Co.Kg Verwendung von Erythropoetin
GEP20084487B (en) * 2002-12-26 2008-09-25 Mountain View Pharmaceuticals Polymer conjugates of cytokines, chemokines, growth factors, polypeptide hormones and antagonists thereof
DE10303584A1 (de) * 2003-01-30 2004-08-12 Stauss, Robert, Dr. Verwendung von Erythropoietin (EPO) als ein Beschichtungsmaterial auf medizinischen Implantaten
EP1699915B1 (de) * 2003-12-30 2010-06-02 Augustinus Bader Verwendung des erythropoietins zur regeneration von lebergewebe

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