RU2006120458A - Способ регенерации ткани - Google Patents

Способ регенерации ткани Download PDF

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Publication number
RU2006120458A
RU2006120458A RU2006120458/13A RU2006120458A RU2006120458A RU 2006120458 A RU2006120458 A RU 2006120458A RU 2006120458/13 A RU2006120458/13 A RU 2006120458/13A RU 2006120458 A RU2006120458 A RU 2006120458A RU 2006120458 A RU2006120458 A RU 2006120458A
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Russia
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use according
epo
cells
tissue
regeneration
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RU2006120458/13A
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English (en)
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RU2392314C2 (ru
Inventor
Аугустинус БАДЕР (DE)
Аугустинус БАДЕР
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Бионетос Холдинг Гмбх (De)
Бионетос Холдинг Гмбх
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Priority claimed from EP03029961A external-priority patent/EP1550715A1/de
Priority claimed from DE10361813A external-priority patent/DE10361813A1/de
Application filed by Бионетос Холдинг Гмбх (De), Бионетос Холдинг Гмбх filed Critical Бионетос Холдинг Гмбх (De)
Publication of RU2006120458A publication Critical patent/RU2006120458A/ru
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Publication of RU2392314C2 publication Critical patent/RU2392314C2/ru

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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/18—Growth factors; Growth regulators
    • A61K38/1816—Erythropoietin [EPO]
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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
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  • Animal Behavior & Ethology (AREA)
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  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Diabetes (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Oral & Maxillofacial Surgery (AREA)
  • Cell Biology (AREA)
  • Transplantation (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Reproductive Health (AREA)
  • Pulmonology (AREA)
  • Physical Education & Sports Medicine (AREA)
  • Physiology (AREA)
  • Developmental Biology & Embryology (AREA)
  • Biotechnology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Pregnancy & Childbirth (AREA)
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Claims (17)

1. Применение нативного или рекомбинантного эритропоэтина (ЭПО) или его сходных по действию производных для регенерации паренхиматозных тканей и образования структур стенок в координированной и трехмерной форме в травматически поврежденных клетках и органах.
2. Применение согласно п.1, отличающееся тем, что применяют рецепторсвязывающий домен ЭПО.
3. Применение согласно п.1 для синтеза тканевых структур и образованных из них функциональных органов.
4. Применение согласно п.3 для регенерации печени.
5. Применение согласно п.3 для заживления ран при структурообразовательном процессе в отношении воспроизведения прежней ткани.
6. Применение согласно п.3 для лечения воспалений и репаративных процессов в области зубов.
7. Применение согласно п.1 или 3, отличающееся тем, что регенерация проходит in vivo.
8. Применение согласно п.1 или 3, отличающееся тем, что регенерация ткани регулируется локально.
9. Применение согласно п.1 или 3, отличающееся тем, что дополнительно используют эндотелиальные клетки.
10. Применение согласно п.1 или 3, отличающееся тем, что дополнительно используют один или несколько факторов роста, выбранных из группы: трансформирующий фактор роста бета (TGF beta), гранулоцитарно-макрофагальный колониестимулирующий фактор (GM-CSF), гранулоцитарный колониестимулирующий фактор (G-CSF), фактор роста нервов (NGF), фактор роста сосудистого эндотелия (VEGF) и тромбоцитарный фактор роста (PDGF).
11. Применение согласно п.1 или 3, отличающееся тем, что используют ЭПО человека.
12. Применение согласно п.1 или 3, отличающееся тем, что ЭПО или один из его производных используются местно.
13. Применение согласно п.1 или 3, отличающееся тем, что ЭПО или один из его производных используется системно.
14. Применение согласно п.1, отличающееся тем, что процесс регенерации поддерживается опорной матрицей, которую обрабатывают ЭПО или одним из его производных.
15. Применение согласно п.14, отличающееся тем, что опорная матрица представляет собой имплантат, трансплантат или опорный материал для размножения клеток.
16. Применение согласно п.14 или 15, отличающееся тем, что опорную матрицу предварительно заселяют тканеспецифичными клетками или клетками-предшественниками взрослых людей, или подготавливают для заселения клетками in vivo или для индуктивной коррекции in vitro.
17. Применение согласно п.16, отличающееся тем, что в качестве клеток используют остеобласты, фибробласты, гепатоциты или гладкомышечные клетки.
RU2006120458/13A 2003-12-30 2004-12-30 Способ регенерации ткани RU2392314C2 (ru)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
EP03029961A EP1550715A1 (de) 2003-12-30 2003-12-30 Verfahren zur Regenation von Gewebe
DE10361813.9 2003-12-30
EP03029961.4 2003-12-30
DE10361813A DE10361813A1 (de) 2003-12-30 2003-12-30 Verfahren zur Regeneration von Gewebe

Related Child Applications (1)

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RU2010105646/10A Division RU2542391C2 (ru) 2003-12-30 2004-12-30 Способ регенерации ткани

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RU2006120458A true RU2006120458A (ru) 2008-02-10
RU2392314C2 RU2392314C2 (ru) 2010-06-20

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RU2006120458/13A RU2392314C2 (ru) 2003-12-30 2004-12-30 Способ регенерации ткани
RU2010105646/10A RU2542391C2 (ru) 2003-12-30 2004-12-30 Способ регенерации ткани

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RU2010105646/10A RU2542391C2 (ru) 2003-12-30 2004-12-30 Способ регенерации ткани

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US (2) US7910547B2 (ru)
EP (2) EP1699915B1 (ru)
JP (2) JP4903580B2 (ru)
AT (1) ATE469654T1 (ru)
AU (2) AU2004309083B2 (ru)
BR (1) BRPI0418326A (ru)
CA (1) CA2550301A1 (ru)
DE (1) DE502004011252D1 (ru)
DK (2) DK1699915T3 (ru)
ES (2) ES2606068T3 (ru)
PL (2) PL2233150T3 (ru)
PT (1) PT1699915E (ru)
RU (2) RU2392314C2 (ru)
WO (1) WO2005063965A1 (ru)

Families Citing this family (44)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE10026480A1 (de) * 2000-05-29 2001-12-13 Augustinus Bader Verfahren zur Herstellung eines empfängerspezifischen Gewebe-Transplantats oder -Implantats
EP1699915B1 (de) 2003-12-30 2010-06-02 Augustinus Bader Verwendung des erythropoietins zur regeneration von lebergewebe
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