FI86077C - Monoklonala antikroppar och metod att producera dessa. - Google Patents
Monoklonala antikroppar och metod att producera dessa. Download PDFInfo
- Publication number
- FI86077C FI86077C FI840219A FI840219A FI86077C FI 86077 C FI86077 C FI 86077C FI 840219 A FI840219 A FI 840219A FI 840219 A FI840219 A FI 840219A FI 86077 C FI86077 C FI 86077C
- Authority
- FI
- Finland
- Prior art keywords
- human
- tumor
- cells
- hybridoma
- monoclonal antibodies
- Prior art date
Links
- 210000004408 hybridoma Anatomy 0.000 claims abstract description 45
- 210000004027 cell Anatomy 0.000 claims abstract description 38
- 238000000338 in vitro Methods 0.000 claims abstract description 6
- 206010028980 Neoplasm Diseases 0.000 claims description 29
- 238000000034 method Methods 0.000 claims description 16
- 206010008342 Cervix carcinoma Diseases 0.000 claims description 12
- 208000006105 Uterine Cervical Neoplasms Diseases 0.000 claims description 12
- 201000010881 cervical cancer Diseases 0.000 claims description 12
- 210000004698 lymphocyte Anatomy 0.000 claims description 12
- 210000001165 lymph node Anatomy 0.000 claims description 9
- 210000004881 tumor cell Anatomy 0.000 claims description 9
- 239000000427 antigen Substances 0.000 claims description 8
- 108091007433 antigens Proteins 0.000 claims description 8
- 102000036639 antigens Human genes 0.000 claims description 8
- 210000003719 b-lymphocyte Anatomy 0.000 claims description 5
- 238000004519 manufacturing process Methods 0.000 claims description 5
- 108090000623 proteins and genes Proteins 0.000 claims description 5
- 210000001519 tissue Anatomy 0.000 claims description 4
- 206010006187 Breast cancer Diseases 0.000 claims description 3
- 208000026310 Breast neoplasm Diseases 0.000 claims description 3
- 206010009944 Colon cancer Diseases 0.000 claims description 3
- 208000029742 colonic neoplasm Diseases 0.000 claims description 3
- 239000012634 fragment Substances 0.000 claims description 3
- 210000005170 neoplastic cell Anatomy 0.000 claims description 3
- 238000012258 culturing Methods 0.000 claims description 2
- 230000001613 neoplastic effect Effects 0.000 claims 2
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 1
- 210000004369 blood Anatomy 0.000 claims 1
- 239000008280 blood Substances 0.000 claims 1
- 208000035269 cancer or benign tumor Diseases 0.000 claims 1
- 238000010367 cloning Methods 0.000 claims 1
- 201000005202 lung cancer Diseases 0.000 claims 1
- 208000020816 lung neoplasm Diseases 0.000 claims 1
- 201000010893 malignant breast melanoma Diseases 0.000 claims 1
- 208000023958 prostate neoplasm Diseases 0.000 claims 1
- 238000012216 screening Methods 0.000 claims 1
- 210000000952 spleen Anatomy 0.000 claims 1
- 238000003745 diagnosis Methods 0.000 abstract description 8
- 238000001727 in vivo Methods 0.000 abstract description 5
- 201000009030 Carcinoma Diseases 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 201000011510 cancer Diseases 0.000 description 10
- 239000002609 medium Substances 0.000 description 7
- 238000002965 ELISA Methods 0.000 description 5
- 108060003951 Immunoglobulin Proteins 0.000 description 5
- 102000018358 immunoglobulin Human genes 0.000 description 5
- 229940027941 immunoglobulin g Drugs 0.000 description 5
- 229940072221 immunoglobulins Drugs 0.000 description 5
- 230000009257 reactivity Effects 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 4
- 210000002950 fibroblast Anatomy 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 3
- 230000027455 binding Effects 0.000 description 3
- 230000008878 coupling Effects 0.000 description 3
- 238000010168 coupling process Methods 0.000 description 3
- 238000005859 coupling reaction Methods 0.000 description 3
- 230000004927 fusion Effects 0.000 description 3
- 239000001963 growth medium Substances 0.000 description 3
- 210000005105 peripheral blood lymphocyte Anatomy 0.000 description 3
- 230000000644 propagated effect Effects 0.000 description 3
- 102000004169 proteins and genes Human genes 0.000 description 3
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 2
- 241000283707 Capra Species 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- ZDXPYRJPNDTMRX-VKHMYHEASA-N L-glutamine Chemical compound OC(=O)[C@@H](N)CCC(N)=O ZDXPYRJPNDTMRX-VKHMYHEASA-N 0.000 description 2
- 229930182816 L-glutamine Natural products 0.000 description 2
- 206010060862 Prostate cancer Diseases 0.000 description 2
- 208000000236 Prostatic Neoplasms Diseases 0.000 description 2
- 229920002684 Sepharose Polymers 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- IQFYYKKMVGJFEH-XLPZGREQSA-N Thymidine Chemical compound O=C1NC(=O)C(C)=CN1[C@@H]1O[C@H](CO)[C@@H](O)C1 IQFYYKKMVGJFEH-XLPZGREQSA-N 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 239000003153 chemical reaction reagent Substances 0.000 description 2
- 210000000349 chromosome Anatomy 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 230000000694 effects Effects 0.000 description 2
- 238000005516 engineering process Methods 0.000 description 2
- 239000011521 glass Substances 0.000 description 2
- 229940094342 human immunoglobulin m Drugs 0.000 description 2
- FDGQSTZJBFJUBT-UHFFFAOYSA-N hypoxanthine Chemical compound O=C1NC=NC2=C1NC=N2 FDGQSTZJBFJUBT-UHFFFAOYSA-N 0.000 description 2
- 230000001900 immune effect Effects 0.000 description 2
- 210000000987 immune system Anatomy 0.000 description 2
- 238000003018 immunoassay Methods 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 210000004072 lung Anatomy 0.000 description 2
- 230000000527 lymphocytic effect Effects 0.000 description 2
- 201000001441 melanoma Diseases 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 239000002953 phosphate buffered saline Substances 0.000 description 2
- 238000002360 preparation method Methods 0.000 description 2
- 210000002307 prostate Anatomy 0.000 description 2
- 239000006152 selective media Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 230000001225 therapeutic effect Effects 0.000 description 2
- 229940104230 thymidine Drugs 0.000 description 2
- JKMHFZQWWAIEOD-UHFFFAOYSA-N 2-[4-(2-hydroxyethyl)piperazin-1-yl]ethanesulfonic acid Chemical compound OCC[NH+]1CCN(CCS([O-])(=O)=O)CC1 JKMHFZQWWAIEOD-UHFFFAOYSA-N 0.000 description 1
- 102100027562 39S ribosomal protein L36, mitochondrial Human genes 0.000 description 1
- DWRXFEITVBNRMK-UHFFFAOYSA-N Beta-D-1-Arabinofuranosylthymine Natural products O=C1NC(=O)C(C)=CN1C1C(O)C(O)C(CO)O1 DWRXFEITVBNRMK-UHFFFAOYSA-N 0.000 description 1
- 208000009458 Carcinoma in Situ Diseases 0.000 description 1
- 241000557626 Corvus corax Species 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- SXRSQZLOMIGNAQ-UHFFFAOYSA-N Glutaraldehyde Chemical compound O=CCCCC=O SXRSQZLOMIGNAQ-UHFFFAOYSA-N 0.000 description 1
- 239000007995 HEPES buffer Substances 0.000 description 1
- 240000000950 Hippophae rhamnoides Species 0.000 description 1
- 235000003145 Hippophae rhamnoides Nutrition 0.000 description 1
- 241000282412 Homo Species 0.000 description 1
- 101000650297 Homo sapiens 39S ribosomal protein L36, mitochondrial Proteins 0.000 description 1
- 108010001336 Horseradish Peroxidase Proteins 0.000 description 1
- UGQMRVRMYYASKQ-UHFFFAOYSA-N Hypoxanthine nucleoside Natural products OC1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 UGQMRVRMYYASKQ-UHFFFAOYSA-N 0.000 description 1
- FBOZXECLQNJBKD-ZDUSSCGKSA-N L-methotrexate Chemical compound C=1N=C2N=C(N)N=C(N)C2=NC=1CN(C)C1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 FBOZXECLQNJBKD-ZDUSSCGKSA-N 0.000 description 1
- 241000712079 Measles morbillivirus Species 0.000 description 1
- 241001494479 Pecora Species 0.000 description 1
- 206010035226 Plasma cell myeloma Diseases 0.000 description 1
- 229920002535 Polyethylene Glycol 1500 Polymers 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108700038980 S-((2-chloroethyl)carbamoyl)glutathione Proteins 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 206010041067 Small cell lung cancer Diseases 0.000 description 1
- 208000034254 Squamous cell carcinoma of the cervix uteri Diseases 0.000 description 1
- 239000002671 adjuvant Substances 0.000 description 1
- 238000001042 affinity chromatography Methods 0.000 description 1
- 230000000735 allogeneic effect Effects 0.000 description 1
- 150000001413 amino acids Chemical group 0.000 description 1
- BFNBIHQBYMNNAN-UHFFFAOYSA-N ammonium sulfate Chemical compound N.N.OS(O)(=O)=O BFNBIHQBYMNNAN-UHFFFAOYSA-N 0.000 description 1
- 229910052921 ammonium sulfate Inorganic materials 0.000 description 1
- 235000011130 ammonium sulphate Nutrition 0.000 description 1
- 238000003556 assay Methods 0.000 description 1
- IQFYYKKMVGJFEH-UHFFFAOYSA-N beta-L-thymidine Natural products O=C1NC(=O)C(C)=CN1C1OC(CO)C(O)C1 IQFYYKKMVGJFEH-UHFFFAOYSA-N 0.000 description 1
- 230000030833 cell death Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 201000006612 cervical squamous cell carcinoma Diseases 0.000 description 1
- 210000003679 cervix uteri Anatomy 0.000 description 1
- 239000007979 citrate buffer Substances 0.000 description 1
- 210000001072 colon Anatomy 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 239000007819 coupling partner Substances 0.000 description 1
- 231100000135 cytotoxicity Toxicity 0.000 description 1
- 230000003013 cytotoxicity Effects 0.000 description 1
- LOKCTEFSRHRXRJ-UHFFFAOYSA-I dipotassium trisodium dihydrogen phosphate hydrogen phosphate dichloride Chemical compound P(=O)(O)(O)[O-].[K+].P(=O)(O)([O-])[O-].[Na+].[Na+].[Cl-].[K+].[Cl-].[Na+] LOKCTEFSRHRXRJ-UHFFFAOYSA-I 0.000 description 1
- 230000005670 electromagnetic radiation Effects 0.000 description 1
- 239000012091 fetal bovine serum Substances 0.000 description 1
- 239000012894 fetal calf serum Substances 0.000 description 1
- 238000001914 filtration Methods 0.000 description 1
- 239000012025 fluorinating agent Substances 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 230000002068 genetic effect Effects 0.000 description 1
- 239000003365 glass fiber Substances 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 229940098197 human immunoglobulin g Drugs 0.000 description 1
- 230000016784 immunoglobulin production Effects 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 210000000265 leukocyte Anatomy 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 239000002502 liposome Substances 0.000 description 1
- 210000002751 lymph Anatomy 0.000 description 1
- 208000019420 lymphoid neoplasm Diseases 0.000 description 1
- 210000005075 mammary gland Anatomy 0.000 description 1
- 229910052751 metal Inorganic materials 0.000 description 1
- 239000002184 metal Substances 0.000 description 1
- 229910052752 metalloid Inorganic materials 0.000 description 1
- 150000002738 metalloids Chemical class 0.000 description 1
- 150000002739 metals Chemical class 0.000 description 1
- 229960000485 methotrexate Drugs 0.000 description 1
- 239000000178 monomer Substances 0.000 description 1
- 201000000050 myeloid neoplasm Diseases 0.000 description 1
- 239000002245 particle Substances 0.000 description 1
- 239000002504 physiological saline solution Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229940093430 polyethylene glycol 1500 Drugs 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 239000002243 precursor Substances 0.000 description 1
- 239000000047 product Substances 0.000 description 1
- 230000002062 proliferating effect Effects 0.000 description 1
- 230000003248 secreting effect Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 210000003491 skin Anatomy 0.000 description 1
- 208000000587 small cell lung carcinoma Diseases 0.000 description 1
- 210000001082 somatic cell Anatomy 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 235000000346 sugar Nutrition 0.000 description 1
- 150000008163 sugars Chemical class 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- VUYXVWGKCKTUMF-UHFFFAOYSA-N tetratriacontaethylene glycol monomethyl ether Chemical compound COCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO VUYXVWGKCKTUMF-UHFFFAOYSA-N 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 108700012359 toxins Proteins 0.000 description 1
- 230000001131 transforming effect Effects 0.000 description 1
- 230000007704 transition Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K51/00—Preparations containing radioactive substances for use in therapy or testing in vivo
- A61K51/02—Preparations containing radioactive substances for use in therapy or testing in vivo characterised by the carrier, i.e. characterised by the agent or material covalently linked or complexing the radioactive nucleus
- A61K51/04—Organic compounds
- A61K51/08—Peptides, e.g. proteins, carriers being peptides, polyamino acids, proteins
- A61K51/10—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody
- A61K51/1045—Antibodies or immunoglobulins; Fragments thereof, the carrier being an antibody, an immunoglobulin or a fragment thereof, e.g. a camelised human single domain antibody or the Fc fragment of an antibody against animal or human tumor cells or tumor cell determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
- C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K38/00—Medicinal preparations containing peptides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2317/00—Immunoglobulins specific features
- C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
- C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- General Health & Medical Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Epidemiology (AREA)
- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Cell Biology (AREA)
- Physics & Mathematics (AREA)
- Pharmacology & Pharmacy (AREA)
- Genetics & Genomics (AREA)
- Molecular Biology (AREA)
- Optics & Photonics (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP57084843A JPS58201994A (ja) | 1982-05-21 | 1982-05-21 | 抗原特異的ヒト免疫グロブリンの生産方法 |
| JP8484382 | 1982-05-21 | ||
| PCT/US1983/000781 WO1983004313A1 (en) | 1982-05-21 | 1983-05-20 | Human-human hybridomas for neoplasms |
| US8300781 | 1983-05-20 |
Publications (4)
| Publication Number | Publication Date |
|---|---|
| FI840219L FI840219L (fi) | 1984-01-19 |
| FI840219A0 FI840219A0 (fi) | 1984-01-19 |
| FI86077B FI86077B (fi) | 1992-03-31 |
| FI86077C true FI86077C (fi) | 1992-07-10 |
Family
ID=13842073
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| FI840219A FI86077C (fi) | 1982-05-21 | 1984-01-19 | Monoklonala antikroppar och metod att producera dessa. |
Country Status (13)
Families Citing this family (116)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA1247538A (en) * | 1982-05-21 | 1988-12-28 | Mark C. Glassy | Human-human hybridomas for solid tumors |
| US4618577A (en) * | 1983-02-09 | 1986-10-21 | The Regents Of The University Of California | Human-human hybridoma, CLNH5 |
| US4939240A (en) * | 1983-03-04 | 1990-07-03 | Health Research, Inc. | Monoclonal antibodies to human breast carcinoma cells and their use in diagnosis and therapy |
| ATE56046T1 (de) * | 1983-03-04 | 1990-09-15 | Health Research Inc | Monoklonale antikoerper gegen humane brustkarzinomzellen und ihre verwendung in der diagnose und therapie. |
| US4613576A (en) * | 1983-03-09 | 1986-09-23 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies to cancer cells |
| US4693966A (en) * | 1983-03-11 | 1987-09-15 | Sloan-Kettering Institute For Cancer Research | Human monoclonal antibodies from lymphocytes of patients with malignant melanoma |
| SE8401945L (sv) * | 1983-04-08 | 1984-11-13 | Kureha Chemical Ind Co Ltd | Antikropp mot cancer i urinblasan hos menniska |
| EP0162070A1 (en) * | 1983-11-25 | 1985-11-27 | The University Of Melbourne | Cell line and monoclonal antibody |
| NZ210867A (en) * | 1984-01-31 | 1989-01-06 | Litton Bionetics Inc | Tumour-specific monoclonal antibodies, production thereof and use |
| US4886745A (en) * | 1984-03-30 | 1989-12-12 | Syntex Inc. | Monoclonal antibody specific for human basal cell surface antigen |
| ES8802196A1 (es) * | 1984-03-30 | 1988-04-16 | Syntex Inc | Metodo para determinar la presion de un estado maligno en tejidos. |
| JPS6133125A (ja) * | 1984-07-25 | 1986-02-17 | Morinaga & Co Ltd | ヒト単クロ−ン性抗肺ガン細胞抗体 |
| US4761377A (en) * | 1984-10-15 | 1988-08-02 | The Regents Of The University Of California | Human-human hybrid cell lines that produce antibodies against antigenic determinants on cancer cells |
| EP0183876A1 (en) * | 1984-11-27 | 1986-06-11 | The Board Of Trustees Of The Leland Stanford Junior University | Monoclonal antibodies for endotoxin core and their use |
| US5106746A (en) * | 1985-05-22 | 1992-04-21 | E. I. Du Pont De Nemours And Company | Process for the in vitro immunization of human splenocytes against tumor associated antigens |
| US5776093A (en) | 1985-07-05 | 1998-07-07 | Immunomedics, Inc. | Method for imaging and treating organs and tissues |
| JPH0655680B2 (ja) * | 1985-10-26 | 1994-07-27 | 萩原 義秀 | 悪性腫瘍用ヒトモノクロナル抗体複合剤 |
| EP0222360A3 (en) * | 1985-11-12 | 1989-03-15 | Biotherapeutics Inc. | A method of producing a patient-specific cytotoxic reagent and composition |
| JPH0767388B2 (ja) * | 1986-01-13 | 1995-07-26 | 三菱化学株式会社 | 抗体産生細胞株の樹立方法 |
| US5434076A (en) * | 1989-12-18 | 1995-07-18 | Board Of Regents, The University Of Texas System | Tumor-specific, cell surface-binding monoclonal antibodies |
| US5281710A (en) * | 1990-08-01 | 1994-01-25 | The Scripps Research Institute | Dynemicin analogs: synthesis, methods of preparation and use |
| JPH04346792A (ja) * | 1991-05-22 | 1992-12-02 | Hagiwara Yoshihide | 抗癌ヒトモノクローナル抗体のアミノ酸配列及びそれをコードするｄｎａ塩基配列 |
| EP0528663B1 (en) * | 1991-08-16 | 1997-10-29 | Kabushiki Kaisha Toshiba | Monoclonal antibody to a synaptophysin |
| DE69839517D1 (de) | 1997-08-15 | 2008-07-03 | Chugai Pharmaceutical Co Ltd | Präventiva oder arzneien enthaltend neutralisierende anti-il6-rezeptor antikörper zur reduktion urinären proteins bei systemischen lupus erythematosus |
| AU784460B2 (en) | 1999-08-23 | 2006-04-06 | Chugai Seiyaku Kabushiki Kaisha | HM1.24 antigen expression potentiators |
| DK1222854T3 (da) | 1999-10-01 | 2011-03-14 | Chugai Pharmaceutical Co Ltd | Forebyggelse og behandling af sygdomme forbundet med blodkoagulering |
| US7931897B2 (en) | 2001-02-07 | 2011-04-26 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agent for hematopoietic tumors |
| UA80091C2 (en) | 2001-04-02 | 2007-08-27 | Chugai Pharmaceutical Co Ltd | Remedies for infant chronic arthritis-relating diseases and still's disease which contain an interleukin-6 (il-6) antagonist |
| EP2311489A3 (en) | 2002-02-14 | 2013-08-21 | Chugai Seiyaku Kabushiki Kaisha | Formulation of antibody-containing solutions comprising a sugar as a stabilizer |
| WO2004019966A1 (ja) | 2002-08-27 | 2004-03-11 | Chugai Seiyaku Kabushiki Kaisha | タンパク質溶液製剤の安定化方法 |
| DK2261230T3 (en) | 2002-09-11 | 2017-06-12 | Chugai Pharmaceutical Co Ltd | Method of Protein Purification. |
| GB2401040A (en) | 2003-04-28 | 2004-11-03 | Chugai Pharmaceutical Co Ltd | Method for treating interleukin-6 related diseases |
| EP2228445A1 (en) | 2003-06-18 | 2010-09-15 | Chugai Seiyaku Kabushiki Kaisha | Fucose Transporter |
| EP2311468B1 (en) | 2003-08-08 | 2014-01-15 | Perseus Proteomics Inc. | Gene overexpressed in cancer |
| US8298816B2 (en) | 2003-12-03 | 2012-10-30 | Chugai Seiyaku Kabushiki Kaisha | Expression systems using mammalian beta-actin promoter |
| JPWO2005056605A1 (ja) | 2003-12-12 | 2007-12-06 | 中外製薬株式会社 | ３量体以上の受容体を認識する改変抗体 |
| KR101300545B1 (ko) | 2004-07-09 | 2013-09-02 | 츄가이 세이야꾸 가부시키가이샤 | 항 글리피칸 3 항체 |
| JPWO2006067847A1 (ja) | 2004-12-22 | 2008-06-12 | 中外製薬株式会社 | フコーストランスポーターの機能が阻害された細胞を用いた抗体の作製方法 |
| EP3050963B1 (en) | 2005-03-31 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Process for production of polypeptide by regulation of assembly |
| AU2006256041B2 (en) | 2005-06-10 | 2012-03-29 | Chugai Seiyaku Kabushiki Kaisha | Stabilizer for protein preparation comprising meglumine and use thereof |
| WO2007043641A1 (ja) | 2005-10-14 | 2007-04-19 | Fukuoka University | 膵島移植における移植膵島障害抑制剤 |
| WO2007055378A1 (ja) | 2005-11-14 | 2007-05-18 | Cell Signals Inc. | 調節性ｔ細胞の機能異常に基づく疾患の治療方法及び予防方法 |
| AR057582A1 (es) | 2005-11-15 | 2007-12-05 | Nat Hospital Organization | Agentes para suprimir la induccion de linfocitos t citotoxicos |
| KR20080084818A (ko) | 2005-11-25 | 2008-09-19 | 각고호우징 게이오기주크 | 전립선암 치료제 |
| AU2007208678B2 (en) | 2006-01-27 | 2013-01-10 | Chugai Seiyaku Kabushiki Kaisha | Therapeutic agents for diseases involving choroidal neovascularization |
| DK2009101T3 (en) | 2006-03-31 | 2018-01-15 | Chugai Pharmaceutical Co Ltd | Antibody modification method for purification of a bispecific antibody |
| JP5624276B2 (ja) | 2006-03-31 | 2014-11-12 | 中外製薬株式会社 | 抗体の血中動態を制御する方法 |
| EP2011870A4 (en) | 2006-04-14 | 2010-09-15 | Medical & Biol Lab Co Ltd | MUTANT POLYPEPTIDE WITH EFFECTOR FUNCTION |
| AU2007255753B2 (en) | 2006-06-08 | 2013-01-17 | Chugai Seiyaku Kabushiki Kaisha | Preventive or remedy for inflammatory disease |
| RU2009100930A (ru) | 2006-06-14 | 2010-07-20 | Чугаи Сейяку Кабусики Кайся (Jp) | Лекарственные средства для стимуляции роста гемопоэтических стволовых клеток |
| TW200808351A (en) | 2006-07-13 | 2008-02-16 | Chugai Pharmaceutical Co Ltd | Cell death-inducing agents |
| WO2008010556A1 (fr) | 2006-07-21 | 2008-01-24 | Chugai Seiyaku Kabushiki Kaisha | Médicament agissant contre une maladie rénale |
| ATE465179T1 (de) | 2006-07-24 | 2010-05-15 | Pasteur Institut | Antikörper, antikörperfragmente und scfv die an posttranslational modifizierte neurotrophine binden |
| EP2548576B1 (en) | 2006-08-14 | 2016-11-30 | Chugai Seiyaku Kabushiki Kaisha | Diagnosis of cancer using anti-desmoglein-3 antibodies |
| WO2008032833A1 (fr) | 2006-09-14 | 2008-03-20 | Medical & Biological Laboratories Co., Ltd. | Anticorps présentant une activité adcc accrue et son procédé de production |
| CN103396486A (zh) | 2006-10-12 | 2013-11-20 | 中外制药株式会社 | 使用抗ereg抗体的癌症的诊断和治疗 |
| CA2666559A1 (en) | 2006-10-20 | 2008-04-24 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-hb-egf antibody as active ingredient |
| WO2008081942A1 (ja) | 2007-01-05 | 2008-07-10 | The University Of Tokyo | 抗prg-3抗体を用いる癌の診断および治療 |
| CA2679266A1 (en) | 2007-02-27 | 2008-09-04 | Forerunner Pharma Research Co., Ltd. | Pharmaceutical composition comprising anti-grp78 antibody as active ingredient |
| WO2009001840A1 (ja) | 2007-06-25 | 2008-12-31 | Forerunner Pharma Research Co., Ltd. | ADCC活性又はCDC活性を有する抗Prominin-1抗体 |
| WO2009014263A1 (ja) | 2007-07-26 | 2009-01-29 | Osaka University | インターロイキン６受容体阻害剤を有効成分とする眼炎症疾患治療剤 |
| EP4368721A3 (en) | 2007-09-26 | 2024-12-18 | Chugai Seiyaku Kabushiki Kaisha | Method of modifying isoelectric point of antibody via amino acid substitution in cdr |
| RU2490025C2 (ru) | 2007-10-02 | 2013-08-20 | Чугаи Сейяку Кабусики Кайся | Терапевтические средства, используемые против реакции трансплантат против хозяина, содержащие в качестве активного ингредиента ингибитор рецептора интерлейкина-6 |
| JP5620106B2 (ja) | 2007-10-24 | 2014-11-05 | 株式会社糖鎖工学研究所 | 増強されたエフェクター機能を有するポリペプチド |
| JP5676107B2 (ja) | 2007-11-14 | 2015-02-25 | 中外製薬株式会社 | 抗ｇｐｒ４９抗体を用いる癌の診断および治療 |
| SG188134A1 (en) | 2007-11-15 | 2013-03-28 | Chugai Pharmaceutical Co Ltd | Monoclonal antibody capable of binding to anexelekto, and use thereof |
| US8431127B2 (en) | 2007-12-05 | 2013-04-30 | Chugai Seiyaku Kabushiki Kaisha | Method for treating pruritus comprising administering an NR10 antagonist |
| EP2236604B1 (en) | 2007-12-05 | 2016-07-06 | Chugai Seiyaku Kabushiki Kaisha | Anti-nr10 antibody and use thereof |
| EP2241333A1 (en) | 2007-12-12 | 2010-10-20 | National Cancer Center | Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof |
| PE20091174A1 (es) | 2007-12-27 | 2009-08-03 | Chugai Pharmaceutical Co Ltd | Formulacion liquida con contenido de alta concentracion de anticuerpo |
| JP5848863B2 (ja) | 2008-01-11 | 2016-01-27 | 国立大学法人 東京大学 | 抗ｃｌｄｎ６抗体 |
| SI2708559T1 (en) | 2008-04-11 | 2018-07-31 | Chugai Seiyaku Kabushiki Kaisha | An antigen-binding molecule capable of repeatably binding to two or more antigenic molecules |
| EP2116261A1 (en) | 2008-05-07 | 2009-11-11 | Institut Pasteur | Sub-region of a plasmodium protein with improved vaccine potential and medical uses thereof |
| EP2283862B1 (en) | 2008-06-02 | 2018-08-08 | The University of Tokyo | Combination treatment of cancer comprising anti-mfg-e8 antibody |
| JP5544290B2 (ja) | 2008-06-05 | 2014-07-09 | 独立行政法人国立がん研究センター | 神経浸潤抑制剤 |
| CA2728473A1 (en) | 2008-06-20 | 2009-12-23 | National University Corporation Okayama University | Antibody against oxidized ldl/.beta.2gpi complex and use of the same |
| CN102395603A (zh) | 2008-12-26 | 2012-03-28 | 国立大学法人东京大学 | 使用抗lgr7抗体的癌症的诊断和治疗 |
| JP2010210772A (ja) | 2009-03-13 | 2010-09-24 | Dainippon Screen Mfg Co Ltd | 液晶表示装置の製造方法 |
| JP5723270B2 (ja) | 2009-05-01 | 2015-05-27 | 国立大学法人 東京大学 | 抗カドヘリン抗体 |
| US20120141501A1 (en) | 2009-05-29 | 2012-06-07 | Forerunner Pharma Research Co. Ltd | Pharmaceutical Composition Containing Antagonist of EGF Family Ligand as Component |
| MY161541A (en) | 2009-07-31 | 2017-04-28 | Shin Maeda | Cancer metastasis inhibitor |
| TW201118166A (en) | 2009-09-24 | 2011-06-01 | Chugai Pharmaceutical Co Ltd | HLA class I-recognizing antibodies |
| AR080428A1 (es) | 2010-01-20 | 2012-04-11 | Chugai Pharmaceutical Co Ltd | Formulaciones liquidas estabilizadas contentivas de anticuerpos |
| RS57008B1 (sr) | 2010-02-10 | 2018-05-31 | Fujifilm Ri Pharma Co Ltd | Anti-kadherin antitelo obeleženo radioaktivnim metalom |
| US20120321557A1 (en) | 2010-02-26 | 2012-12-20 | Forerunner Pharma Research Co., Ltd. | Anti-icam3 antibody and use thereof |
| EP4501956A2 (en) | 2010-03-30 | 2025-02-05 | Chugai Seiyaku Kabushiki Kaisha | Antigen-binding molecules that promote antigen clearance |
| TWI667346B (zh) | 2010-03-30 | 2019-08-01 | 中外製藥股份有限公司 | 促進抗原消失之具有經修飾的FcRn親和力之抗體 |
| PL2578231T3 (pl) | 2010-05-28 | 2023-01-16 | Chugai Seiyaku Kabushiki Kaisha | Środek wzmacniający przeciwnowotworową odpowiedź limfocytów t |
| CN103491978A (zh) | 2010-10-25 | 2014-01-01 | 明尼苏达大学评议会 | 用于治疗成胶质细胞瘤的治疗组合物 |
| EP3404043B1 (en) | 2010-10-29 | 2022-10-26 | Perseus Proteomics Inc. | Anti-cdh3 antibody having high internalization capacity |
| US9574005B2 (en) | 2011-07-19 | 2017-02-21 | Chugai Seiyaku Kabushiki Kaisha | Stable Protein-containing preparation containing argininamide or analogous compound thereof |
| US9550835B2 (en) | 2011-08-23 | 2017-01-24 | Chugai Seiyaku Kabushiki Kaisha | Anti-DDR1 antibody having anti-tumor activity |
| TW201817744A (zh) | 2011-09-30 | 2018-05-16 | 日商中外製藥股份有限公司 | 具有促進抗原清除之ＦｃＲｎ結合域的治療性抗原結合分子 |
| WO2013062083A1 (ja) | 2011-10-28 | 2013-05-02 | ファーマロジカルズ・リサーチ プライベート リミテッド | 癌幹細胞特異的分子 |
| WO2013065708A1 (ja) | 2011-10-31 | 2013-05-10 | 中外製薬株式会社 | 重鎖と軽鎖の会合が制御された抗原結合分子 |
| KR20150003251A (ko) | 2012-04-04 | 2015-01-08 | 가부시키가이샤 페르세우스 프로테오믹스 | 항 cdh3(p-카드헤린) 항체의 약물 콘쥬게이트 |
| JP6519851B2 (ja) | 2012-07-06 | 2019-05-29 | 京都府公立大学法人 | 眼細胞の分化マーカーおよび分化制御 |
| AU2013320972B2 (en) | 2012-09-27 | 2018-08-30 | Chugai Seiyaku Kabushiki Kaisha | FGFR3 fusion gene and pharmaceutical drug targeting same |
| JP6442404B2 (ja) | 2013-06-11 | 2018-12-19 | 国立研究開発法人国立精神・神経医療研究センター | 再発寛解型多発性硬化症（ｒｒｍｓ）患者の治療予後予測方法、及び新規治療適応判断方法 |
| EP3087986B1 (en) | 2013-12-27 | 2019-09-18 | Chugai Seiyaku Kabushiki Kaisha | Fgfr gatekeeper mutant gene and drug targeting same |
| WO2016027859A1 (ja) | 2014-08-20 | 2016-02-25 | 中外製薬株式会社 | 蛋白質溶液の粘度測定方法 |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| WO2016136933A1 (ja) | 2015-02-27 | 2016-09-01 | 中外製薬株式会社 | Ｉｌ－６関連疾患治療用組成物 |
| KR20190133005A (ko) | 2017-03-24 | 2019-11-29 | 젠야쿠코교가부시키가이샤 | 항 IgM/B 세포 표면 항원 이중 특이성 항체 |
| WO2019078344A1 (ja) | 2017-10-20 | 2019-04-25 | 学校法人兵庫医科大学 | 抗ｉｌ－６受容体抗体を含有する術後の癒着を抑制するための医薬組成物 |
| WO2019151418A1 (ja) | 2018-01-31 | 2019-08-08 | 元一 加藤 | Ｉｌ－６阻害剤を含有する喘息の治療剤 |
| WO2020175689A1 (ja) | 2019-02-28 | 2020-09-03 | 学校法人順天堂 | 切断型の変異型Ｃａｌｒｅｔｉｃｕｌｉｎに結合する抗体、及び骨髄増殖性腫瘍の診断、予防又は治療薬 |
| US20220204608A1 (en) | 2019-04-17 | 2022-06-30 | Hiroshima University | Therapeutic agent for urological cancer which is characterized by being administered with il-6 inhibitor and ccr2 inhibitor in combination |
| JP7684656B2 (ja) | 2019-06-11 | 2025-05-28 | 小野薬品工業株式会社 | 免疫抑制剤 |
| US20230149555A1 (en) | 2020-04-06 | 2023-05-18 | PhotoQ3 Inc. | Medicament for killing tumor cells |
| IL300182A (en) | 2020-07-28 | 2023-03-01 | Chugai Pharmaceutical Co Ltd | Preparation of a pre-filled syringe with a needle, supplied with a needle guard and containing a new modified antibody |
| EP4205764A4 (en) | 2020-08-27 | 2024-10-30 | Juntendo Educational Foundation | BISPECIFIC ANTIBODY CALR-CD3 MUTANT ANTI-TRUNCATED AND PHARMACEUTICAL COMPOSITION |
| KR20230156368A (ko) | 2021-03-12 | 2023-11-14 | 추가이 세이야쿠 가부시키가이샤 | 중증 근무력증의 치료 또는 예방용의 의약 조성물 |
| CN118043031A (zh) | 2021-10-04 | 2024-05-14 | 诺华股份有限公司 | 表面活性剂稳定剂 |
| CA3239389A1 (en) | 2021-12-01 | 2023-06-08 | Kohei SOEDA | Method for preparing antibody-containing formulation |
| TW202342097A (zh) | 2022-02-25 | 2023-11-01 | 學校法人順天堂 | 抗突變calr抗體與其他藥劑組合而成之醫藥 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS57502090A (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) * | 1980-07-18 | 1982-11-25 | ||
| NZ198851A (en) * | 1980-11-07 | 1984-07-31 | Wistar Inst | Stable,continuous human myeloma cell line capable of hybridisation with antibody-producing cells:production of hybrid cell line |
-
1982
- 1982-05-21 JP JP57084843A patent/JPS58201994A/ja active Granted
-
1983
- 1983-05-19 CZ CS833566A patent/CZ280677B6/cs not_active IP Right Cessation
- 1983-05-19 SK SK3566-83A patent/SK279249B6/sk unknown
- 1983-05-20 JP JP58502264A patent/JPS60501359A/ja active Pending
- 1983-05-20 AT AT83902157T patent/ATE114189T1/de not_active IP Right Cessation
- 1983-05-20 HU HU832697A patent/HU190908B/hu not_active IP Right Cessation
- 1983-05-20 DE DE3382764T patent/DE3382764T2/de not_active Expired - Lifetime
- 1983-05-20 WO PCT/US1983/000781 patent/WO1983004313A1/en active IP Right Grant
- 1983-05-20 EP EP83902157A patent/EP0109441B1/en not_active Expired - Lifetime
- 1983-05-20 AU AU17729/83A patent/AU560595B2/en not_active Expired
- 1983-05-23 ZA ZA833686A patent/ZA833686B/xx unknown
- 1983-05-31 IN IN683/CAL/83A patent/IN157982B/en unknown
-
1984
- 1984-01-19 FI FI840219A patent/FI86077C/fi not_active IP Right Cessation
- 1984-01-20 DK DK025084A patent/DK164510C/da not_active IP Right Cessation
Also Published As
| Publication number | Publication date |
|---|---|
| EP0109441A4 (en) | 1986-09-22 |
| FI86077B (fi) | 1992-03-31 |
| JPS60501359A (ja) | 1985-08-22 |
| AU1772983A (en) | 1983-12-16 |
| DK164510C (da) | 1992-11-23 |
| FI840219L (fi) | 1984-01-19 |
| AU560595B2 (en) | 1987-04-09 |
| SK356683A3 (en) | 1998-08-05 |
| IN157982B (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1986-08-09 |
| CZ356683A3 (en) | 1995-11-15 |
| EP0109441B1 (en) | 1994-11-17 |
| DK25084D0 (da) | 1984-01-20 |
| EP0109441A1 (en) | 1984-05-30 |
| DE3382764D1 (de) | 1994-12-22 |
| DE3382764T2 (de) | 1995-03-16 |
| JPH0159878B2 (GUID-C5D7CC26-194C-43D0-91A1-9AE8C70A9BFF.html) | 1989-12-20 |
| SK279249B6 (sk) | 1998-08-05 |
| FI840219A0 (fi) | 1984-01-19 |
| WO1983004313A1 (en) | 1983-12-08 |
| HU190908B (en) | 1986-12-28 |
| ATE114189T1 (de) | 1994-12-15 |
| JPS58201994A (ja) | 1983-11-25 |
| CZ280677B6 (cs) | 1996-04-17 |
| DK164510B (da) | 1992-07-06 |
| DK25084A (da) | 1984-01-20 |
| ZA833686B (en) | 1984-09-26 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| FI86077C (fi) | Monoklonala antikroppar och metod att producera dessa. | |
| US4618577A (en) | Human-human hybridoma, CLNH5 | |
| EP0068763B1 (en) | Recombinant monoclonal antibodies | |
| JPS61500789A (ja) | モノクロ−ナル抗−ヒト乳癌抗体 | |
| CA1247538A (en) | Human-human hybridomas for solid tumors | |
| US5286647A (en) | Human-human hybridomas for neoplasms | |
| JPS59137497A (ja) | 抗原特異的免疫グロブリン生産性ヒト／ヒトハイブリド−マ及びその生産する抗体 | |
| JPS62174100A (ja) | Ｇｔ―２に特異的なモノクローナル抗体 | |
| JP2555028B2 (ja) | ヒト非−小細胞肺癌に関するモノクロ−ナル抗体 | |
| JPH0246297A (ja) | モノクローナル抗体、抗体産生ハイブリドーマおよび抗体の製造法 | |
| US7074613B1 (en) | Monoclonal antibody directed against cells of human renal cell carcinoma | |
| Dan et al. | Human antiglioma monoclonal antibodies from patients with astrocytic tumors | |
| CA1315220C (en) | Preparation of monoclonal antibodies capable of reacting with human breast carcinoma cells | |
| JP2626979B2 (ja) | ヒト癌細胞に対するモノクロナール抗体４ｃ１および該抗体を産生するハイブリドーマ | |
| NO165510B (no) | Monoklonale antistoffer, samt anvendelse av dem in vitro for bestemmelse av naervaer av neoplasmer. | |
| JPH01243986A (ja) | 抗ヒト固形癌ヒトモノクローナル抗体，抗体産生ハイブリドーマおよび抗体の製造法 | |
| Werner et al. | Human monoclonal antibodies directed against ovarian carcinoma | |
| JP2002519020A (ja) | 腫瘍抗原ｕｋ１１４に対するヒトモノクローナル抗体並びにそれらの産生のためのリンパ性細胞及びハイブリドーマ | |
| Waelti et al. | Monoclonal Human Antitumor Antibodies: Search for Specific B-Lymphocytes Suitable for Fusion | |
| JPS6233199A (ja) | モノクロ−ナル抗体 | |
| EP0285052A2 (en) | Monoclonal antibody | |
| WAELTI et al. | Freiburgstrasse 30, CH-3010 Bern | |
| JPH04187096A (ja) | 二重特異性を有するハイブリッド・モノクローナル抗体 | |
| VAN SOEST et al. | Idiotype Rescue from Hairy Cell Leukemia by Somatic Cell Hybridization | |
| JPS61249999A (ja) | モノクロ−ナル抗体 |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MA | Patent expired |
Owner name: THE REGENTS OF THE UNIVERSITY OF |