FI120685B - Menetelmä HIV-aspartyyliproteaasin sulfonamidi-inhibiittoreiden valmistamiseksi - Google Patents

Menetelmä HIV-aspartyyliproteaasin sulfonamidi-inhibiittoreiden valmistamiseksi Download PDF

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FI120685B
FI120685B FI951059A FI951059A FI120685B FI 120685 B FI120685 B FI 120685B FI 951059 A FI951059 A FI 951059A FI 951059 A FI951059 A FI 951059A FI 120685 B FI120685 B FI 120685B
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compound
syn
hydroxy
phenyl
butyl
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FI951059A
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Finnish (fi)
Swedish (sv)
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FI951059A0 (fi
FI951059L (fi
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Roger D Tung
Mark A Murcko
Govinda Rao Bhisetti
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Vertex Pharma
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    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
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    • A61P31/18—Antivirals for RNA viruses for HIV
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    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/12—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings
    • C07C311/13—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an unsaturated carbon skeleton containing rings the carbon skeleton containing six-membered aromatic rings
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    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
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    • C07C311/18—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom to an acyclic carbon atom of a hydrocarbon radical substituted by nitrogen atoms, not being part of nitro or nitroso groups
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    • C07C311/38—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton
    • C07C311/39—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups having the sulfur atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring having sulfur atoms of sulfonamide groups and amino groups bound to carbon atoms of six-membered rings of the same carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to hydrogen atoms or to an acyclic carbon atom
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    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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EP0659181B1 (en) 1999-04-07
EP0885887A2 (en) 1998-12-23
HK1012631A1 (en) 1999-08-06
NO303444B1 (no) 1998-07-13
CA2143208A1 (en) 1994-03-17
LU90736I2 (fr) 2001-05-07
NO950876L (no) 1995-05-08
NZ256238A (en) 1997-04-24
AU4852093A (en) 1994-03-29
SG43862A1 (en) 1997-11-14
IL106927A (en) 2001-01-11
US20080293727A1 (en) 2008-11-27
US20030069222A1 (en) 2003-04-10
US20100210603A1 (en) 2010-08-19
HK1023561A1 (en) 2000-09-15
SK281360B6 (sk) 2001-02-12
NO950876D0 (no) 1995-03-07
PT885887E (pt) 2003-10-31
MXPA03010538A (es) 2011-12-16
CY2164B1 (en) 2002-08-23
BG62488B1 (bg) 1999-12-30
EP0885887A3 (en) 1999-02-03
DE69333012T2 (de) 2004-04-01
DE69324369D1 (de) 1999-05-12
AU691160B2 (en) 1998-05-14
TW254927B (OSRAM) 1995-08-21
IS4068A (is) 1994-03-09
HU228198B1 (en) 2013-01-28
AP9300572A0 (en) 1993-10-31
US7608632B2 (en) 2009-10-27
ES2200243T3 (es) 2004-03-01
CA2143208C (en) 2003-01-07
DK0885887T3 (da) 2003-09-22
DE69324369T2 (de) 1999-08-26
NO2001012I1 (no) 2001-07-23
FI951059A0 (fi) 1995-03-07
US20060189810A1 (en) 2006-08-24
CZ58795A3 (en) 1995-12-13
LT3302B (en) 1995-06-26
US5856353A (en) 1999-01-05
JP3012002B2 (ja) 2000-02-21
SK29395A3 (en) 1995-09-13
FI951059L (fi) 1995-04-18
DK0659181T3 (da) 1999-10-18
HU9500685D0 (en) 1995-04-28
DE10199024I2 (de) 2006-04-06
NZ314376A (en) 1998-10-28
AP390A (en) 1995-08-02
RU95109928A (ru) 1997-03-20
JPH08501299A (ja) 1996-02-13
IS2334B (is) 2008-02-15
ATE178598T1 (de) 1999-04-15
RO118747B1 (ro) 2003-10-30
BG99540A (bg) 1995-11-30
MY142901A (en) 2011-01-31
CZ289475B6 (cs) 2002-01-16
NL300039I2 (nl) 2001-09-03
GEP20012579B (en) 2001-11-26
US5585397A (en) 1996-12-17
WO1994005639A1 (en) 1994-03-17
BR1100824A (pt) 1999-08-31
ATE241602T1 (de) 2003-06-15
DE10199024I1 (de) 2001-07-12
DE69333012D1 (de) 2003-07-03
CO4870779A1 (es) 1999-12-27
ES2131589T3 (es) 1999-08-01
RU2135496C1 (ru) 1999-08-27
HUT71892A (en) 1996-02-28
UA44694C2 (uk) 2002-03-15
US6372778B1 (en) 2002-04-16
EP0885887B1 (en) 2003-05-28
IL106927A0 (en) 1993-12-28
CN1087347A (zh) 1994-06-01
PH31251A (en) 1998-05-05
PL185635B1 (pl) 2003-06-30
CN1061339C (zh) 2001-01-31
EP0659181A1 (en) 1995-06-28
LTIP917A (en) 1994-11-25
KR100262056B1 (ko) 2000-07-15
PL307858A1 (en) 1995-06-26
GR3030719T3 (en) 1999-11-30

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