FI109542B - Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi - Google Patents

Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi Download PDF

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Publication number
FI109542B
FI109542B FI954327A FI954327A FI109542B FI 109542 B FI109542 B FI 109542B FI 954327 A FI954327 A FI 954327A FI 954327 A FI954327 A FI 954327A FI 109542 B FI109542 B FI 109542B
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FI
Finland
Prior art keywords
compound
seq
formula
xaa xaa
nos
Prior art date
Application number
FI954327A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI954327A (fi
FI954327A0 (fi
Inventor
James M Balkovec
Regina M Black
Frances Aileen Bouffard
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI109542(B) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI954327A publication Critical patent/FI954327A/fi
Publication of FI954327A0 publication Critical patent/FI954327A0/fi
Application granted granted Critical
Publication of FI109542B publication Critical patent/FI109542B/fi

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Chemical Vapour Deposition (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
FI954327A 1993-03-16 1995-09-14 Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi FI109542B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US3284793 1993-03-16
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds
PCT/US1994/002580 WO1994021677A1 (fr) 1993-03-16 1994-03-10 Composes d'aza cyclohexapeptide
US9402580 1994-03-10

Publications (3)

Publication Number Publication Date
FI954327A FI954327A (fi) 1995-09-14
FI954327A0 FI954327A0 (fi) 1995-09-14
FI109542B true FI109542B (fi) 2002-08-30

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954327A FI109542B (fi) 1993-03-16 1995-09-14 Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi

Country Status (33)

Country Link
US (3) US5378804A (fr)
EP (1) EP0620232B1 (fr)
JP (1) JP2568474B2 (fr)
KR (1) KR100329693B1 (fr)
CN (1) CN1098274C (fr)
AT (1) ATE186736T1 (fr)
AU (1) AU668804B2 (fr)
BG (1) BG63047B1 (fr)
BR (2) BR9406009A (fr)
CA (1) CA2118757C (fr)
CZ (1) CZ286235B6 (fr)
DE (2) DE10299013I2 (fr)
DK (1) DK0620232T3 (fr)
ES (1) ES2139043T3 (fr)
FI (1) FI109542B (fr)
GR (1) GR3031872T3 (fr)
HK (1) HK1008674A1 (fr)
HR (1) HRP940161B1 (fr)
HU (2) HU217614B (fr)
IL (1) IL108892A (fr)
LU (1) LU90875I2 (fr)
LV (1) LV12574B (fr)
NL (1) NL300076I2 (fr)
NO (2) NO318372B1 (fr)
NZ (1) NZ263360A (fr)
PL (1) PL179261B1 (fr)
RO (1) RO113246B1 (fr)
RU (1) RU2122548C1 (fr)
SI (1) SI9420013B (fr)
SK (1) SK282527B6 (fr)
UA (1) UA59329C2 (fr)
WO (1) WO1994021677A1 (fr)
ZA (1) ZA941807B (fr)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1996006109A1 (fr) * 1994-08-23 1996-02-29 Merck & Co., Inc. Procede ameliore pour preparer des derives de lipopeptides cyclohexapeptidiques ayant des chaines laterales
AU692308B2 (en) * 1994-09-16 1998-06-04 Merck Sharp & Dohme Corp. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
EP0805685B1 (fr) * 1995-01-26 2001-09-26 Merck & Co., Inc. Nouveaux cyclohexapeptides antifongiques
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
CA2265824C (fr) * 1996-09-12 2004-11-09 Merck & Co., Inc. Therapie antifongique combinee
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
WO2001007468A2 (fr) * 1999-07-27 2001-02-01 Aventis Pharma Deutschland Gmbh Nouveaux composes cyclohexapeptides, procedes de production et utilisation de ces derniers comme produit pharmaceutique
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
JP4625637B2 (ja) 2002-02-22 2011-02-02 シャイア エルエルシー 活性物質送達系及び活性物質を保護し投与する方法
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
DE602004010915T2 (de) * 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
EP1730180A4 (fr) * 2004-02-24 2008-06-18 Commw Scient Ind Res Org Peptides antifongiques
EP1785432A1 (fr) 2005-11-15 2007-05-16 Sandoz AG Procédé et produits intermédiaires pour la synthèse du caspofungin.
WO2008012310A1 (fr) 2006-07-26 2008-01-31 Sandoz Ag Préparations à base de caspofungine
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
CA2692053A1 (fr) 2007-06-26 2008-12-31 Merck Sharp & Dohme Corp. Composition antifongique lyophilisee
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (fr) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Procédés pour préparer des azacyclohexapeptides de pureté élevée
EP2183271A1 (fr) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Caspofungine débarrassée de l'impureté a des caspofungines
WO2010064219A1 (fr) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Procédé de préparation d'un nouvel intermédiaire de la caspofungine
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (fr) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Composé cristallisé
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (fr) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptide ou son sel pharmaceutiquement acceptable, procédé de préparation et utilisation afférente
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
AU2011304408B2 (en) 2010-09-20 2015-01-15 Xellia Pharmaceuticals Aps Caspofungin composition
CA2813330A1 (fr) * 2010-09-29 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Procede de purification de composes lipopeptides cycliques ou de leurs sels
EP2623611B1 (fr) * 2010-09-30 2016-07-13 Shanghai Techwell Biopharmaceutical Co., Ltd Procédé de purification d'un lipopeptide cyclique ou de son sel
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
EP2661441A4 (fr) * 2011-01-03 2015-04-08 Biocon Ltd Procédé de préparation d'acétate de caspofungine et de ses intermédiaires
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
RS56426B1 (sr) 2011-03-03 2018-01-31 Cidara Therapeutics Inc Antigljivična sredstva i njihova upotreba
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
KR20140042805A (ko) 2011-04-28 2014-04-07 유니트리스 바이오파마 컴퍼니 리미티드 카스포펀진 합성을 위한 중간체 및 그 제조 방법
JP6117907B2 (ja) 2012-03-19 2017-04-19 シダラ セラピューティクス インコーポレーテッド エキノキャンディン系化合物のための投与レジメン
PT2922530T (pt) 2012-11-20 2016-12-22 Fresenius Kabi Usa Llc Formulações de acetato de caspofungina
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
US9675659B2 (en) 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
US10369188B2 (en) 2016-01-08 2019-08-06 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
EP3430400B1 (fr) 2016-03-16 2023-06-21 Cidara Therapeutics, Inc. Schémas posologiques pour le traitement d'infections fongiques
WO2017185030A1 (fr) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Formulation de caspofungine à faible taux d'impuretés
CA3069423A1 (fr) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. Formulations pour le traitement des infections fongiques
WO2019157453A1 (fr) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Compositions de caspofongine pour inhalation
EP3620462A1 (fr) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Procédé de préparation de caspofungine

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
GB2065130A (en) * 1979-12-13 1981-06-24 Lilly Co Eli Recovery process for a-30912 antibiotics
DE3030554A1 (de) * 1980-08-13 1982-03-25 Chemische Werke Hüls AG, 4370 Marl Einbrennlacke
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
IL105048A (en) * 1992-03-19 2001-06-14 Eli Lilly And Company U S Antifungal substances of the cyclic peptide type and a process for their preparation
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
HK1008674A1 (en) 1999-05-14
UA59329C2 (uk) 2003-09-15
SI9420013B (sl) 2002-12-31
SK282527B6 (sk) 2002-10-08
IL108892A (en) 1998-07-15
NO2005020I1 (no) 2005-09-13
ES2139043T3 (es) 2000-02-01
LV12574B (en) 2001-04-20
CZ286235B6 (cs) 2000-02-16
ATE186736T1 (de) 1999-12-15
CN1098274C (zh) 2003-01-08
NO953648D0 (no) 1995-09-15
EP0620232A1 (fr) 1994-10-19
LU90875I2 (en) 2002-03-04
US5514650A (en) 1996-05-07
BR1100273A (pt) 1999-10-13
CA2118757A1 (fr) 1994-09-17
NZ263360A (en) 1997-08-22
HRP940161A2 (en) 1996-08-31
JPH06321986A (ja) 1994-11-22
SI9420013A (en) 1996-08-31
KR960701092A (ko) 1996-02-24
HU211890A9 (en) 1995-12-28
NO2005020I2 (no) 2008-12-01
RO113246B1 (ro) 1998-05-29
PL310634A1 (en) 1995-12-27
BR9406009A (pt) 1995-12-26
NL300076I1 (nl) 2002-03-01
HUT73496A (en) 1996-08-28
DE10299013I1 (de) 2003-01-23
AU5783294A (en) 1994-09-22
HU9502703D0 (en) 1995-11-28
GR3031872T3 (en) 2000-02-29
SK113695A3 (en) 1996-02-07
CA2118757C (fr) 2002-05-14
BG99999A (bg) 1996-04-30
US5792746A (en) 1998-08-11
CZ235895A3 (en) 1996-02-14
NO318372B1 (no) 2005-03-14
ZA941807B (en) 1994-10-13
BG63047B1 (bg) 2001-02-28
FI954327A (fi) 1995-09-14
IL108892A0 (en) 1994-06-24
HU217614B (hu) 2000-03-28
FI954327A0 (fi) 1995-09-14
KR100329693B1 (ko) 2002-08-14
EP0620232B1 (fr) 1999-11-17
JP2568474B2 (ja) 1997-01-08
AU668804B2 (en) 1996-05-16
DE10299013I2 (de) 2009-11-19
DE69421639T2 (de) 2000-06-08
DK0620232T3 (da) 2000-03-13
RU2122548C1 (ru) 1998-11-27
NL300076I2 (nl) 2002-04-02
NO953648L (no) 1995-11-15
US5378804A (en) 1995-01-03
CN1119441A (zh) 1996-03-27
HRP940161B1 (en) 2001-04-30
DE69421639D1 (de) 1999-12-23
LV12574A (en) 2000-11-20
WO1994021677A1 (fr) 1994-09-29
PL179261B1 (pl) 2000-08-31

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