DK0620232T3 - Azacyclohexapeptid-forbindelser - Google Patents

Azacyclohexapeptid-forbindelser

Info

Publication number
DK0620232T3
DK0620232T3 DK94200604T DK94200604T DK0620232T3 DK 0620232 T3 DK0620232 T3 DK 0620232T3 DK 94200604 T DK94200604 T DK 94200604T DK 94200604 T DK94200604 T DK 94200604T DK 0620232 T3 DK0620232 T3 DK 0620232T3
Authority
DK
Denmark
Prior art keywords
compounds
azacyclohexapeptid
ceretain
found
preparation
Prior art date
Application number
DK94200604T
Other languages
English (en)
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DK0620232(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of DK0620232T3 publication Critical patent/DK0620232T3/da

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK94200604T 1993-03-16 1994-03-09 Azacyclohexapeptid-forbindelser DK0620232T3 (da)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
DK0620232T3 true DK0620232T3 (da) 2000-03-13

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
DK94200604T DK0620232T3 (da) 1993-03-16 1994-03-09 Azacyclohexapeptid-forbindelser

Country Status (32)

Country Link
US (3) US5378804A (da)
EP (1) EP0620232B1 (da)
JP (1) JP2568474B2 (da)
KR (1) KR100329693B1 (da)
CN (1) CN1098274C (da)
AT (1) ATE186736T1 (da)
AU (1) AU668804B2 (da)
BG (1) BG63047B1 (da)
BR (2) BR9406009A (da)
CA (1) CA2118757C (da)
CZ (1) CZ286235B6 (da)
DE (2) DE10299013I2 (da)
DK (1) DK0620232T3 (da)
ES (1) ES2139043T3 (da)
FI (1) FI109542B (da)
GR (1) GR3031872T3 (da)
HR (1) HRP940161B1 (da)
HU (2) HU217614B (da)
IL (1) IL108892A (da)
LU (1) LU90875I2 (da)
LV (1) LV12574B (da)
NL (1) NL300076I2 (da)
NO (2) NO318372B1 (da)
NZ (1) NZ263360A (da)
PL (1) PL179261B1 (da)
RO (1) RO113246B1 (da)
RU (1) RU2122548C1 (da)
SI (1) SI9420013B (da)
SK (1) SK282527B6 (da)
UA (1) UA59329C2 (da)
WO (1) WO1994021677A1 (da)
ZA (1) ZA941807B (da)

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US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
DE69513408T2 (de) * 1994-08-23 2000-06-08 Merck & Co., Inc. Ein verbessertes verfahren für die herstellung von seitenketten-derivaten von cyclohexapeptidyl-lipopeptiden
EP0781141B1 (en) * 1994-09-16 2002-09-04 Merck & Co. Inc. Aza cyclohexapeptide compounds
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
PT805685E (pt) * 1995-01-26 2002-02-28 Merck & Co Inc Novos ciclo-hexapeptideos anti-fungicos
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
CN1235554A (zh) * 1996-09-12 1999-11-17 麦克公司 抗真菌的联合治疗
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU6564000A (en) * 1999-07-27 2001-02-13 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
EP1423414A4 (en) * 2001-08-06 2005-11-30 Cubist Pharm Inc NEW DEPSIPEPTIDES AND METHOD FOR THE PRODUCTION THEREOF
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
EP1654036B1 (en) * 2003-07-22 2007-12-26 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
EP1730180A4 (en) * 2004-02-24 2008-06-18 Commw Scient Ind Res Org Antifungal peptides
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
JP5373606B2 (ja) * 2006-07-26 2013-12-18 サンド・アクチエンゲゼルシヤフト カスポファンギン製剤
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
EP2170362B1 (en) 2007-06-26 2015-11-04 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2009158034A1 (en) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (en) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
PL2618814T3 (pl) 2010-09-20 2017-01-31 Xellia Pharmaceuticals Aps Kompozycja kaspofunginy
US8927690B2 (en) * 2010-09-29 2015-01-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
US8877777B2 (en) * 2010-09-30 2014-11-04 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CA2865791C (en) 2011-03-03 2019-10-08 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
WO2012146099A1 (zh) 2011-04-28 2012-11-01 上海源力生物技术有限公司 用于合成卡帕芬净的中间体及其制备方法
SI3677252T1 (sl) 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
PL2922530T3 (pl) * 2012-11-20 2017-04-28 Fresenius Kabi Usa, Llc Formulacje octanu kaspofunginy
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
US9675659B2 (en) 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
US10369188B2 (en) 2016-01-08 2019-08-06 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
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DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
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Also Published As

Publication number Publication date
NO318372B1 (no) 2005-03-14
DE69421639D1 (de) 1999-12-23
HU211890A9 (en) 1995-12-28
NL300076I1 (nl) 2002-03-01
ZA941807B (en) 1994-10-13
US5378804A (en) 1995-01-03
RU2122548C1 (ru) 1998-11-27
GR3031872T3 (en) 2000-02-29
CN1098274C (zh) 2003-01-08
EP0620232A1 (en) 1994-10-19
DE10299013I1 (de) 2003-01-23
BR9406009A (pt) 1995-12-26
SI9420013B (sl) 2002-12-31
NO953648D0 (no) 1995-09-15
US5514650A (en) 1996-05-07
BG99999A (bg) 1996-04-30
HU217614B (hu) 2000-03-28
SK282527B6 (sk) 2002-10-08
IL108892A0 (en) 1994-06-24
JPH06321986A (ja) 1994-11-22
NL300076I2 (nl) 2002-04-02
WO1994021677A1 (en) 1994-09-29
HK1008674A1 (en) 1999-05-14
IL108892A (en) 1998-07-15
NO2005020I2 (no) 2008-12-01
BG63047B1 (bg) 2001-02-28
DE69421639T2 (de) 2000-06-08
BR1100273A (pt) 1999-10-13
ES2139043T3 (es) 2000-02-01
NO953648L (no) 1995-11-15
FI954327A0 (fi) 1995-09-14
US5792746A (en) 1998-08-11
KR960701092A (ko) 1996-02-24
CA2118757A1 (en) 1994-09-17
AU5783294A (en) 1994-09-22
LV12574B (en) 2001-04-20
DE10299013I2 (de) 2009-11-19
NO2005020I1 (no) 2005-09-13
LV12574A (en) 2000-11-20
NZ263360A (en) 1997-08-22
CA2118757C (en) 2002-05-14
SK113695A3 (en) 1996-02-07
FI109542B (fi) 2002-08-30
CZ286235B6 (cs) 2000-02-16
FI954327L (fi) 1995-09-14
LU90875I2 (en) 2002-03-04
ATE186736T1 (de) 1999-12-15
JP2568474B2 (ja) 1997-01-08
CN1119441A (zh) 1996-03-27
PL310634A1 (en) 1995-12-27
HRP940161B1 (en) 2001-04-30
RO113246B1 (ro) 1998-05-29
KR100329693B1 (ko) 2002-08-14
UA59329C2 (uk) 2003-09-15
HRP940161A2 (en) 1996-08-31
SI9420013A (en) 1996-08-31
EP0620232B1 (en) 1999-11-17
PL179261B1 (pl) 2000-08-31
CZ235895A3 (en) 1996-02-14
AU668804B2 (en) 1996-05-16
HUT73496A (en) 1996-08-28
HU9502703D0 (en) 1995-11-28

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