DE10299013I1 - Aza-Zyklohexapeptide - Google Patents

Aza-Zyklohexapeptide

Info

Publication number
DE10299013I1
DE10299013I1 DE2002199013 DE10299013C DE10299013I1 DE 10299013 I1 DE10299013 I1 DE 10299013I1 DE 2002199013 DE2002199013 DE 2002199013 DE 10299013 C DE10299013 C DE 10299013C DE 10299013 I1 DE10299013 I1 DE 10299013I1
Authority
DE
Germany
Prior art keywords
aza
zyklohexapeptide
ceretain
found
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2002199013
Other languages
English (en)
Other versions
DE10299013I2 (de
Inventor
James Balkovec
Regina Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10299013(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of DE10299013I1 publication Critical patent/DE10299013I1/de
Publication of DE10299013I2 publication Critical patent/DE10299013I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Chemical Vapour Deposition (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
DE10299013C 1993-03-16 1994-03-09 Aza-Zyklohexapeptide Active DE10299013I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
DE10299013I1 true DE10299013I1 (de) 2003-01-23
DE10299013I2 DE10299013I2 (de) 2009-11-19

Family

ID=21867140

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10299013C Active DE10299013I2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide
DE69421639T Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69421639T Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Country Status (33)

Country Link
US (3) US5378804A (de)
EP (1) EP0620232B1 (de)
JP (1) JP2568474B2 (de)
KR (1) KR100329693B1 (de)
CN (1) CN1098274C (de)
AT (1) ATE186736T1 (de)
AU (1) AU668804B2 (de)
BG (1) BG63047B1 (de)
BR (2) BR9406009A (de)
CA (1) CA2118757C (de)
CZ (1) CZ286235B6 (de)
DE (2) DE10299013I2 (de)
DK (1) DK0620232T3 (de)
ES (1) ES2139043T3 (de)
FI (1) FI109542B (de)
GR (1) GR3031872T3 (de)
HK (1) HK1008674A1 (de)
HR (1) HRP940161B1 (de)
HU (2) HU217614B (de)
IL (1) IL108892A (de)
LU (1) LU90875I2 (de)
LV (1) LV12574B (de)
NL (1) NL300076I2 (de)
NO (2) NO318372B1 (de)
NZ (1) NZ263360A (de)
PL (1) PL179261B1 (de)
RO (1) RO113246B1 (de)
RU (1) RU2122548C1 (de)
SI (1) SI9420013B (de)
SK (1) SK282527B6 (de)
UA (1) UA59329C2 (de)
WO (1) WO1994021677A1 (de)
ZA (1) ZA941807B (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1996006109A1 (en) * 1994-08-23 1996-02-29 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
ATE223226T1 (de) * 1994-09-16 2002-09-15 Merck & Co Inc Azazyklohexapeptid-verbindungen
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
CA2211138A1 (en) * 1995-01-26 1996-08-01 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
JP2000501076A (ja) * 1995-11-09 2000-02-02 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルビスアミン化合物、その化合物を含む組成物とその使用方法
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
EA002469B1 (ru) * 1996-09-12 2002-06-27 Мерк Энд Ко., Инк. Способ лечения грибковой инфекции
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
DE60040989D1 (de) * 1999-07-27 2009-01-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
IL163666A0 (en) 2002-02-22 2005-12-18 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
ES2298821T3 (es) 2003-07-22 2008-05-16 Theravance, Inc. Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico.
CN1950396A (zh) * 2004-02-24 2007-04-18 联邦科学技术研究组织 抗真菌肽
EP1785432A1 (de) * 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
EP2340846A1 (de) * 2006-07-26 2011-07-06 Sandoz Ag Zusammensetzungen enthaltend Caspofungin
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
JP5537425B2 (ja) 2007-06-26 2014-07-02 メルク・シャープ・アンド・ドーム・コーポレーション 凍結乾燥抗真菌組成物
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
EP2240507A2 (de) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur herstellung von hochreinen azacyclohexapeptiden
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (de) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptid bzw. sein pharmazeutisch akzeptables salz, herstellungsverfahren und verwendung
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
KR20130136466A (ko) 2010-09-20 2013-12-12 셀리아 파마슈티칼즈 에이피에스 카스포펀진 조성물
KR101514903B1 (ko) * 2010-09-29 2015-04-23 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 사이클릭 리포펩타이드 화합물 또는 그의 염의 정제방법
CN102443050B (zh) * 2010-09-30 2014-06-04 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
RS56426B1 (sr) 2011-03-03 2018-01-31 Cidara Therapeutics Inc Antigljivična sredstva i njihova upotreba
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
MX2013012161A (es) 2011-04-28 2014-07-30 Unitris Biopharma Co Ltd Compuesto intermedio de la sintesis de caspofungina y metodo de preparacion de la misma.
KR102236462B1 (ko) 2012-03-19 2021-04-08 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
LT2922530T (lt) * 2012-11-20 2017-01-25 Fresenius Kabi Usa, Llc Kaspofungino acetato kompozicijos
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
WO2017034961A1 (en) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
US10369188B2 (en) 2016-01-08 2019-08-06 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
MA43825A (fr) 2016-03-16 2021-04-07 Cidara Therapeutics Inc Schémas posologiques pour le traitement d'infections fongiques
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
JP2020529973A (ja) 2017-07-12 2020-10-15 シダラ セラピューティクス インコーポレーテッド 真菌感染症の処置のための組成物及び方法
WO2019157453A1 (en) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Caspofungin compositions for inhalation
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
GB2065130A (en) * 1979-12-13 1981-06-24 Lilly Co Eli Recovery process for a-30912 antibiotics
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
DE3030554A1 (de) * 1980-08-13 1982-03-25 Chemische Werke Hüls AG, 4370 Marl Einbrennlacke
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc History of Echinocandin Antifungal Antibiotics, Its Production and Pharmaceutical Preparations Containing It
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
CZ288974B6 (cs) * 1992-03-19 2001-10-17 Eli Lilly And Company Acylový derivát echinocandinu, způsob jeho přípravy, farmaceutický prostředek s jeho obsahem a jeho pouľití
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
HRP940161A2 (en) 1996-08-31
NZ263360A (en) 1997-08-22
IL108892A0 (en) 1994-06-24
BG63047B1 (bg) 2001-02-28
FI109542B (fi) 2002-08-30
HU217614B (hu) 2000-03-28
US5378804A (en) 1995-01-03
FI954327A0 (fi) 1995-09-14
ATE186736T1 (de) 1999-12-15
RO113246B1 (ro) 1998-05-29
IL108892A (en) 1998-07-15
FI954327A (fi) 1995-09-14
HUT73496A (en) 1996-08-28
LV12574B (en) 2001-04-20
ZA941807B (en) 1994-10-13
NO953648D0 (no) 1995-09-15
EP0620232B1 (de) 1999-11-17
BR1100273A (pt) 1999-10-13
DE69421639T2 (de) 2000-06-08
AU5783294A (en) 1994-09-22
CN1119441A (zh) 1996-03-27
KR960701092A (ko) 1996-02-24
KR100329693B1 (ko) 2002-08-14
PL310634A1 (en) 1995-12-27
DE10299013I2 (de) 2009-11-19
SI9420013B (sl) 2002-12-31
CZ235895A3 (en) 1996-02-14
NO953648L (no) 1995-11-15
PL179261B1 (pl) 2000-08-31
SK282527B6 (sk) 2002-10-08
WO1994021677A1 (en) 1994-09-29
NO318372B1 (no) 2005-03-14
NO2005020I2 (no) 2008-12-01
RU2122548C1 (ru) 1998-11-27
ES2139043T3 (es) 2000-02-01
HK1008674A1 (en) 1999-05-14
NL300076I1 (nl) 2002-03-01
SK113695A3 (en) 1996-02-07
JPH06321986A (ja) 1994-11-22
SI9420013A (en) 1996-08-31
BR9406009A (pt) 1995-12-26
US5792746A (en) 1998-08-11
GR3031872T3 (en) 2000-02-29
HU211890A9 (en) 1995-12-28
HRP940161B1 (en) 2001-04-30
HU9502703D0 (en) 1995-11-28
BG99999A (bg) 1996-04-30
UA59329C2 (uk) 2003-09-15
NL300076I2 (nl) 2002-04-02
AU668804B2 (en) 1996-05-16
CN1098274C (zh) 2003-01-08
DE69421639D1 (de) 1999-12-23
LV12574A (en) 2000-11-20
US5514650A (en) 1996-05-07
EP0620232A1 (de) 1994-10-19
CA2118757A1 (en) 1994-09-17
CA2118757C (en) 2002-05-14
JP2568474B2 (ja) 1997-01-08
LU90875I2 (en) 2002-03-04
CZ286235B6 (cs) 2000-02-16
DK0620232T3 (da) 2000-03-13
NO2005020I1 (no) 2005-09-13

Similar Documents

Publication Publication Date Title
DE10299013I2 (de) Aza-Zyklohexapeptide
PL300066A1 (en) Novel 7-(substituted)-8-(substituted)-9-(substituted amino)-6-demethyl-6-deoxy-tyetracyclines, methods of obtaining them and pharmaceutical composition
AU4461393A (en) Novel 7-(substituted)-8-(substituted-9-{(substituted glycyl) amido}-6-demethyl-6-deoxytetracyclines
SG47559A1 (en) 7-(substituted)-9-[(substituted glycl) amido]-6-demethyl-6-deoxytetracyclines
CY2543B1 (en) 9-Ä(Substituted glycyl)amidoÜ-6-(substituted)-5-hydroxy-6-deoxytetracyclines