DE10299013I1 - Aza-Zyklohexapeptide - Google Patents

Aza-Zyklohexapeptide

Info

Publication number
DE10299013I1
DE10299013I1 DE2002199013 DE10299013C DE10299013I1 DE 10299013 I1 DE10299013 I1 DE 10299013I1 DE 2002199013 DE2002199013 DE 2002199013 DE 10299013 C DE10299013 C DE 10299013C DE 10299013 I1 DE10299013 I1 DE 10299013I1
Authority
DE
Germany
Prior art keywords
zyklohexapeptide
aza
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
DE2002199013
Other languages
English (en)
Other versions
DE10299013I2 (de
Inventor
James Balkovec
Regina Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US08/032,847 priority Critical patent/US5378804A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE10299013I1 publication Critical patent/DE10299013I1/de
Application granted granted Critical
Publication of DE10299013I2 publication Critical patent/DE10299013I2/de
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10299013(I1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application status is Active legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/27Cyclic peptide or cyclic protein
DE2002199013 1993-03-16 1994-03-09 Aza-Zyklohexapeptide Active DE10299013I2 (de)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
DE10299013I1 true DE10299013I1 (de) 2003-01-23
DE10299013I2 DE10299013I2 (de) 2009-11-19

Family

ID=21867140

Family Applications (2)

Application Number Title Priority Date Filing Date
DE2002199013 Active DE10299013I2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide
DE1994621639 Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE1994621639 Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Country Status (31)

Country Link
US (3) US5378804A (de)
EP (1) EP0620232B1 (de)
JP (1) JP2568474B2 (de)
CN (1) CN1098274C (de)
AT (1) AT186736T (de)
AU (1) AU668804B2 (de)
BG (1) BG63047B1 (de)
BR (2) BR9406009A (de)
CA (1) CA2118757C (de)
CZ (1) CZ286235B6 (de)
DE (2) DE10299013I2 (de)
DK (1) DK0620232T3 (de)
ES (1) ES2139043T3 (de)
FI (1) FI109542B (de)
GR (1) GR3031872T3 (de)
HK (1) HK1008674A1 (de)
HR (1) HRP940161B1 (de)
HU (2) HU217614B (de)
IL (1) IL108892A (de)
LU (1) LU90875I2 (de)
LV (1) LV12574B (de)
NL (1) NL300076I2 (de)
NO (2) NO318372B1 (de)
NZ (1) NZ263360A (de)
PL (1) PL179261B1 (de)
RO (1) RO113246B1 (de)
RU (1) RU2122548C1 (de)
SI (1) SI9420013B (de)
SK (1) SK282527B6 (de)
WO (1) WO1994021677A1 (de)
ZA (1) ZA9401807B (de)

Families Citing this family (59)

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US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
JP3118466B2 (ja) * 1994-08-23 2000-12-18 メルク エンド カンパニー インコーポレーテッド シクロヘキサペプチジルリポペプチドの側鎖誘導体の改良製造方法
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
WO1996008266A1 (en) * 1994-09-16 1996-03-21 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
JP2966936B2 (ja) * 1995-01-26 1999-10-25 メルク エンド カンパニー インコーポレーテッド 新規抗真菌シクロヘキサペプチド
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
AT248625T (de) * 1996-09-12 2003-09-15 Merck & Co Inc Fungizide kombinationstherapie
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
US7166572B1 (en) * 1999-07-27 2007-01-23 Aventis Pharma Deutschland Gmbh Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
JP4664912B2 (ja) * 2003-07-22 2011-04-06 セラヴァンス, インコーポレーテッド グリコペプチド抗菌剤と組み合わせたエキノカンジン抗真菌剤の使用
US20080032924A1 (en) * 2004-02-24 2008-02-07 Peter David East Antifungal Peptides
EP1785432A1 (de) * 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
JP5373606B2 (ja) * 2006-07-26 2013-12-18 サンド・アクチエンゲゼルシヤフト カスポファンギン製剤
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
JP5537425B2 (ja) * 2007-06-26 2014-07-02 メルク・シャープ・アンド・ドーム・コーポレーションMerck Sharp & Dohme Corp. 凍結乾燥抗真菌組成物
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
CN102076707A (zh) * 2008-06-25 2011-05-25 特瓦药厂私人有限公司 无卡泊芬净杂质a的卡泊芬净
EP2240507A2 (de) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Verfahren zur herstellung von hochreinen azacyclohexapeptiden
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TWI374894B (de) * 2008-12-31 2012-10-21
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
WO2011014990A1 (zh) * 2009-08-06 2011-02-10 上海天伟生物制药有限公司 一种氮杂环己肽或其药学上可接受的盐及其制备方法和用途
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司;上海医药工业研究院 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
RS55216B1 (sr) 2010-09-20 2017-02-28 Xellia Pharmaceuticals Aps Kompozicija kaspofungina
US8927690B2 (en) * 2010-09-29 2015-01-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
EP2623611B1 (de) * 2010-09-30 2016-07-13 Shanghai Techwell Biopharmaceutical Co., Ltd Verfahren zur reinigung eines zyklischen lipopeptids oder eines salzes davon
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
NO2680873T3 (de) 2011-03-03 2018-01-06
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
WO2012146099A1 (zh) 2011-04-28 2012-11-01 上海源力生物技术有限公司 用于合成卡帕芬净的中间体及其制备方法
EP2827710A4 (de) 2012-03-19 2015-11-25 Cidara Therapeutics Inc Dosierschemata für verbindungen der echinocandin-klasse
LT2922530T (lt) * 2012-11-20 2017-01-25 Fresenius Kabi Usa, Llc Kaspofungino acetato kompozicijos
CN105481952A (zh) * 2014-12-24 2016-04-13 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
US9675659B2 (en) 2015-08-21 2017-06-13 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
WO2017120471A1 (en) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities

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DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
GB2065130A (en) * 1979-12-13 1981-06-24 Lilly Co Eli Recovery process for a-30912 antibiotics
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
IL94862A (en) * 1989-06-30 1994-10-07 Merck & Co Inc Antifungal antibiotic echinocandin derivative, its production and pharmaceutical compositions containing it
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
TW264477B (de) * 1992-03-19 1995-12-01 Lilly Co Eli
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
US5378804A (en) 1995-01-03
CN1119441A (zh) 1996-03-27
CA2118757C (en) 2002-05-14
LU90875I2 (en) 2002-03-04
HU211890A9 (en) 1995-12-28
IL108892D0 (en) 1994-06-24
HRP940161A2 (en) 1996-08-31
FI954327A (fi) 1995-09-14
BG99999A (bg) 1996-04-30
CZ235895A3 (en) 1996-02-14
RU2122548C1 (ru) 1998-11-27
FI954327D0 (de)
NL300076I1 (nl) 2002-03-01
BR9406009A (pt) 1995-12-26
ZA9401807B (en) 1994-10-13
WO1994021677A1 (en) 1994-09-29
FI954327A0 (fi) 1995-09-14
JP2568474B2 (ja) 1997-01-08
FI109542B (fi) 2002-08-30
ES2139043T3 (es) 2000-02-01
HK1008674A1 (en) 2000-07-07
SI9420013A (en) 1996-08-31
EP0620232B1 (de) 1999-11-17
NL300076I2 (nl) 2002-04-02
DE69421639D1 (de) 1999-12-23
BG63047B1 (bg) 2001-02-28
NZ263360A (en) 1997-08-22
HU217614B (hu) 2000-03-28
FI109542B1 (de)
NO318372B1 (no) 2005-03-14
CZ286235B6 (cs) 2000-02-16
SI9420013B (sl) 2002-12-31
HUT73496A (en) 1996-08-28
PL310634A1 (en) 1995-12-27
EP0620232A1 (de) 1994-10-19
LV12574B (en) 2001-04-20
HU9502703D0 (en) 1995-11-28
DK620232T3 (de)
RO113246B1 (ro) 1998-05-29
NO2005020I1 (no) 2005-09-13
PL179261B1 (en) 2000-08-31
DK0620232T3 (da) 2000-03-13
SK282527B6 (sk) 2002-10-08
AU5783294A (en) 1994-09-22
NO953648D0 (no) 1995-09-15
GR3031872T3 (en) 2000-02-29
CA2118757A1 (en) 1994-09-17
CN1098274C (zh) 2003-01-08
IL108892A (en) 1998-07-15
KR960701092A (ko) 1996-02-24
US5514650A (en) 1996-05-07
JPH06321986A (ja) 1994-11-22
SK113695A3 (en) 1996-02-07
US5792746A (en) 1998-08-11
AU668804B2 (en) 1996-05-16
LU90875A9 (de)
HRP940161B1 (en) 2001-04-30
NO953648L (no) 1995-11-15
AT186736T (de) 1999-12-15
DE10299013I2 (de) 2009-11-19
LV12574A (en) 2000-11-20
BR1100273A (pt) 1999-10-13
NO2005020I2 (no) 2008-12-01
DE69421639T2 (de) 2000-06-08

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