FI954327A0 - Atsasykloheksapeptidiyhdisteitä - Google Patents

Atsasykloheksapeptidiyhdisteitä

Info

Publication number
FI954327A0
FI954327A0 FI954327A FI954327A FI954327A0 FI 954327 A0 FI954327 A0 FI 954327A0 FI 954327 A FI954327 A FI 954327A FI 954327 A FI954327 A FI 954327A FI 954327 A0 FI954327 A0 FI 954327A0
Authority
FI
Finland
Prior art keywords
azacyklohexapeptidföreningar
ceretain
found
preparation
novel processes
Prior art date
Application number
FI954327A
Other languages
English (en)
Swedish (sv)
Other versions
FI954327A (fi
FI109542B (fi
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=FI954327(A0) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of FI954327A publication Critical patent/FI954327A/fi
Publication of FI954327A0 publication Critical patent/FI954327A0/fi
Application granted granted Critical
Publication of FI109542B publication Critical patent/FI109542B/fi

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein
FI954327A 1993-03-16 1995-09-14 Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi FI109542B (fi)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds
US3284793 1993-03-16
US9402580 1994-03-10
PCT/US1994/002580 WO1994021677A1 (en) 1993-03-16 1994-03-10 Aza cyclohexapeptide compounds

Publications (3)

Publication Number Publication Date
FI954327A FI954327A (fi) 1995-09-14
FI954327A0 true FI954327A0 (fi) 1995-09-14
FI109542B FI109542B (fi) 2002-08-30

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
FI954327A FI109542B (fi) 1993-03-16 1995-09-14 Menetelmä lääkeaineina käyttökelpoisten atsasykloheksapeptidiyhdisteiden valmistamiseksi

Country Status (33)

Country Link
US (3) US5378804A (fi)
EP (1) EP0620232B1 (fi)
JP (1) JP2568474B2 (fi)
KR (1) KR100329693B1 (fi)
CN (1) CN1098274C (fi)
AT (1) ATE186736T1 (fi)
AU (1) AU668804B2 (fi)
BG (1) BG63047B1 (fi)
BR (2) BR9406009A (fi)
CA (1) CA2118757C (fi)
CZ (1) CZ286235B6 (fi)
DE (2) DE10299013I2 (fi)
DK (1) DK0620232T3 (fi)
ES (1) ES2139043T3 (fi)
FI (1) FI109542B (fi)
GR (1) GR3031872T3 (fi)
HK (1) HK1008674A1 (fi)
HR (1) HRP940161B1 (fi)
HU (2) HU217614B (fi)
IL (1) IL108892A (fi)
LU (1) LU90875I2 (fi)
LV (1) LV12574B (fi)
NL (1) NL300076I2 (fi)
NO (2) NO318372B1 (fi)
NZ (1) NZ263360A (fi)
PL (1) PL179261B1 (fi)
RO (1) RO113246B1 (fi)
RU (1) RU2122548C1 (fi)
SI (1) SI9420013B (fi)
SK (1) SK282527B6 (fi)
UA (1) UA59329C2 (fi)
WO (1) WO1994021677A1 (fi)
ZA (1) ZA941807B (fi)

Families Citing this family (63)

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US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
WO1996006109A1 (en) * 1994-08-23 1996-02-29 Merck & Co., Inc. An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
AU692308B2 (en) * 1994-09-16 1998-06-04 Merck Sharp & Dohme Corp. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
PT805685E (pt) * 1995-01-26 2002-02-28 Merck & Co Inc Novos ciclo-hexapeptideos anti-fungicos
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
AU721334B2 (en) * 1996-09-12 2000-06-29 Merck Sharp & Dohme Corp. Antifungal combination therapy
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
DE60040989D1 (de) * 1999-07-27 2009-01-15 Aventis Pharma Gmbh Cyclohexapeptide, deren herstellung und verwendung in pharmazeutische zusammensetzungen
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
KR20040088519A (ko) 2002-02-22 2004-10-16 뉴 리버 파마슈티칼스, 인크. 활성 제제 전달 시스템 및 활성 제제의 보호 및 투여 방법
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
DE602004010915T2 (de) 2003-07-22 2008-12-11 Theravance, Inc., South San Francisco Verwendung eines antimykotischen echinocandin-mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CA2557333A1 (en) * 2004-02-24 2005-09-01 Commonwealth Scientific And Industrial Research Organisation Antifungal peptides
EP1785432A1 (en) * 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
US8232245B2 (en) 2006-07-26 2012-07-31 Sandoz Ag Caspofungin formulations
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
EP2170362B1 (en) 2007-06-26 2015-11-04 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
EP2183271A1 (en) * 2008-06-25 2010-05-12 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Caspofungin free of caspofungin impurity a
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (en) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co AZACYCLOHEXAPEPTIDE BZW. ITS PHARMACEUTICAL ACCEPTABLE SALT, MANUFACTURING PROCESS AND USE
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
KR20130136466A (ko) 2010-09-20 2013-12-12 셀리아 파마슈티칼즈 에이피에스 카스포펀진 조성물
KR101514903B1 (ko) * 2010-09-29 2015-04-23 샹하이 테크웰 바이오파마슈티컬 컴퍼니, 리미티드 사이클릭 리포펩타이드 화합물 또는 그의 염의 정제방법
WO2012041220A1 (zh) * 2010-09-30 2012-04-05 上海天伟生物制药有限公司 一种环脂肽化合物或其盐的纯化方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
EP2661441A4 (en) * 2011-01-03 2015-04-08 Biocon Ltd PROCESS FOR THE PREPARATION OF ACETATE CASPOFUNGIN AND ITS INTERMEDIATES
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CA2865791C (en) 2011-03-03 2019-10-08 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
RU2592280C2 (ru) 2011-04-28 2016-07-20 Юнитрис Биофарма Ко., Лтд Промежуточное соединение для синтеза каспофунгина и способ его получения
KR102236462B1 (ko) 2012-03-19 2021-04-08 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
DK2922530T3 (en) 2012-11-20 2017-01-09 Fresenius Kabi Usa Llc Caspofunginacetatformuleringer
CN105481952B (zh) * 2014-12-24 2020-12-29 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
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Also Published As

Publication number Publication date
JPH06321986A (ja) 1994-11-22
NL300076I2 (nl) 2002-04-02
AU668804B2 (en) 1996-05-16
BG63047B1 (bg) 2001-02-28
PL179261B1 (pl) 2000-08-31
CA2118757C (en) 2002-05-14
NZ263360A (en) 1997-08-22
HU211890A9 (en) 1995-12-28
US5378804A (en) 1995-01-03
US5792746A (en) 1998-08-11
CN1119441A (zh) 1996-03-27
NO318372B1 (no) 2005-03-14
SI9420013A (en) 1996-08-31
HRP940161B1 (en) 2001-04-30
NO953648D0 (no) 1995-09-15
GR3031872T3 (en) 2000-02-29
IL108892A (en) 1998-07-15
BR9406009A (pt) 1995-12-26
WO1994021677A1 (en) 1994-09-29
CA2118757A1 (en) 1994-09-17
PL310634A1 (en) 1995-12-27
NO2005020I2 (no) 2008-12-01
DE10299013I1 (de) 2003-01-23
FI954327A (fi) 1995-09-14
JP2568474B2 (ja) 1997-01-08
KR960701092A (ko) 1996-02-24
SI9420013B (sl) 2002-12-31
DE69421639D1 (de) 1999-12-23
LV12574B (en) 2001-04-20
BR1100273A (pt) 1999-10-13
NO953648L (no) 1995-11-15
HUT73496A (en) 1996-08-28
LU90875I2 (en) 2002-03-04
UA59329C2 (uk) 2003-09-15
NO2005020I1 (no) 2005-09-13
HK1008674A1 (en) 1999-05-14
CZ286235B6 (cs) 2000-02-16
RO113246B1 (ro) 1998-05-29
DK0620232T3 (da) 2000-03-13
CN1098274C (zh) 2003-01-08
BG99999A (bg) 1996-04-30
NL300076I1 (nl) 2002-03-01
AU5783294A (en) 1994-09-22
EP0620232A1 (en) 1994-10-19
DE69421639T2 (de) 2000-06-08
EP0620232B1 (en) 1999-11-17
ATE186736T1 (de) 1999-12-15
RU2122548C1 (ru) 1998-11-27
SK282527B6 (sk) 2002-10-08
IL108892A0 (en) 1994-06-24
DE10299013I2 (de) 2009-11-19
SK113695A3 (en) 1996-02-07
HU9502703D0 (en) 1995-11-28
CZ235895A3 (en) 1996-02-14
FI109542B (fi) 2002-08-30
HRP940161A2 (en) 1996-08-31
US5514650A (en) 1996-05-07
HU217614B (hu) 2000-03-28
LV12574A (en) 2000-11-20
ES2139043T3 (es) 2000-02-01
KR100329693B1 (ko) 2002-08-14
ZA941807B (en) 1994-10-13

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