ES2139043T3 - Compuestos de azaciclohexapeptidos. - Google Patents

Compuestos de azaciclohexapeptidos.

Info

Publication number
ES2139043T3
ES2139043T3 ES94200604T ES94200604T ES2139043T3 ES 2139043 T3 ES2139043 T3 ES 2139043T3 ES 94200604 T ES94200604 T ES 94200604T ES 94200604 T ES94200604 T ES 94200604T ES 2139043 T3 ES2139043 T3 ES 2139043T3
Authority
ES
Spain
Prior art keywords
compounds
azaciclohexapeptide
ceretain
azo
found
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94200604T
Other languages
English (en)
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2139043(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2139043T3 publication Critical patent/ES2139043T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biochemistry (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)

Abstract

COMPUESTOS DE CERETAIN AZO CICLOHEXAPEPTIDO SE HAN ENCONTRADO PARA TENER PROPIEDADES ANTIBIOTICAS SUPERIORES. NUEVOS PROCESOS PARA SU PREPARACION TAMBIEN SE DESCRIBEN.
ES94200604T 1993-03-16 1994-03-09 Compuestos de azaciclohexapeptidos. Expired - Lifetime ES2139043T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
ES2139043T3 true ES2139043T3 (es) 2000-02-01

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94200604T Expired - Lifetime ES2139043T3 (es) 1993-03-16 1994-03-09 Compuestos de azaciclohexapeptidos.

Country Status (32)

Country Link
US (3) US5378804A (es)
EP (1) EP0620232B1 (es)
JP (1) JP2568474B2 (es)
KR (1) KR100329693B1 (es)
CN (1) CN1098274C (es)
AT (1) ATE186736T1 (es)
AU (1) AU668804B2 (es)
BG (1) BG63047B1 (es)
BR (2) BR9406009A (es)
CA (1) CA2118757C (es)
CZ (1) CZ286235B6 (es)
DE (2) DE10299013I2 (es)
DK (1) DK0620232T3 (es)
ES (1) ES2139043T3 (es)
FI (1) FI109542B (es)
GR (1) GR3031872T3 (es)
HR (1) HRP940161B1 (es)
HU (2) HU217614B (es)
IL (1) IL108892A (es)
LU (1) LU90875I2 (es)
LV (1) LV12574B (es)
NL (1) NL300076I2 (es)
NO (2) NO318372B1 (es)
NZ (1) NZ263360A (es)
PL (1) PL179261B1 (es)
RO (1) RO113246B1 (es)
RU (1) RU2122548C1 (es)
SI (1) SI9420013B (es)
SK (1) SK282527B6 (es)
UA (1) UA59329C2 (es)
WO (1) WO1994021677A1 (es)
ZA (1) ZA941807B (es)

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US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
CA2195975C (en) * 1994-08-23 2001-05-15 James M. Balkovec An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
ES2181790T3 (es) * 1994-09-16 2003-03-01 Merck & Co Inc Compuestos azaciclohexapeptidicos.
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
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WO1998010782A1 (en) * 1996-09-12 1998-03-19 Merck & Co., Inc. Antifungal combination therapy
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
EP1204677B1 (en) * 1999-07-27 2008-12-03 Aventis Pharma Deutschland GmbH Cyclohexapeptide compounds, process for their production and their use as a pharmaceutical
WO2003079972A2 (en) 2002-02-22 2003-10-02 New River Parmaceuticals Inc. Active agent delivery systems and methods for protecting and administering active agents
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US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
ES2298821T3 (es) 2003-07-22 2008-05-16 Theravance, Inc. Utilizacion de un agente antifungico de equinocandina en combinacion con un agente antibacteriano glicopeptidico.
EA012569B1 (ru) * 2004-02-24 2009-10-30 Коммонвелт Сайентифик Энд Индастриал Рисёч Организейшн Пептид насекомых, обладающий противогрибковой и/или антибактериальной активностью, и способы его применения
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
EP2340846A1 (en) 2006-07-26 2011-07-06 Sandoz Ag Caspofungin formulations
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
CA2692053A1 (en) * 2007-06-26 2008-12-31 Merck Sharp & Dohme Corp. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
KR20110011704A (ko) * 2008-06-25 2011-02-08 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
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WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
US20120190815A1 (en) * 2009-08-06 2012-07-26 Tianhui Xu Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
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EP2623511B1 (en) * 2010-09-29 2016-04-06 Shanghai Techwell Biopharmaceutical Co., Ltd Process for purifying cyclic lipopeptide compounds or salts thereof
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Also Published As

Publication number Publication date
DE69421639D1 (de) 1999-12-23
HUT73496A (en) 1996-08-28
SI9420013A (en) 1996-08-31
CA2118757A1 (en) 1994-09-17
LU90875I2 (en) 2002-03-04
NZ263360A (en) 1997-08-22
UA59329C2 (uk) 2003-09-15
DK0620232T3 (da) 2000-03-13
AU5783294A (en) 1994-09-22
HU211890A9 (en) 1995-12-28
KR100329693B1 (ko) 2002-08-14
NO318372B1 (no) 2005-03-14
KR960701092A (ko) 1996-02-24
CZ235895A3 (en) 1996-02-14
WO1994021677A1 (en) 1994-09-29
CZ286235B6 (cs) 2000-02-16
FI954327L (fi) 1995-09-14
HK1008674A1 (en) 1999-05-14
DE10299013I1 (de) 2003-01-23
FI954327A0 (fi) 1995-09-14
GR3031872T3 (en) 2000-02-29
HU217614B (hu) 2000-03-28
NL300076I1 (nl) 2002-03-01
JPH06321986A (ja) 1994-11-22
LV12574B (en) 2001-04-20
NO953648L (no) 1995-11-15
LV12574A (en) 2000-11-20
NO2005020I2 (no) 2008-12-01
HRP940161B1 (en) 2001-04-30
CA2118757C (en) 2002-05-14
CN1119441A (zh) 1996-03-27
DE69421639T2 (de) 2000-06-08
BG99999A (bg) 1996-04-30
JP2568474B2 (ja) 1997-01-08
NO2005020I1 (no) 2005-09-13
RU2122548C1 (ru) 1998-11-27
SK113695A3 (en) 1996-02-07
ZA941807B (en) 1994-10-13
IL108892A0 (en) 1994-06-24
EP0620232B1 (en) 1999-11-17
CN1098274C (zh) 2003-01-08
NO953648D0 (no) 1995-09-15
FI109542B (fi) 2002-08-30
SK282527B6 (sk) 2002-10-08
US5514650A (en) 1996-05-07
AU668804B2 (en) 1996-05-16
BG63047B1 (bg) 2001-02-28
HRP940161A2 (en) 1996-08-31
EP0620232A1 (en) 1994-10-19
RO113246B1 (ro) 1998-05-29
ATE186736T1 (de) 1999-12-15
NL300076I2 (nl) 2002-04-02
SI9420013B (sl) 2002-12-31
BR1100273A (pt) 1999-10-13
DE10299013I2 (de) 2009-11-19
HU9502703D0 (en) 1995-11-28
US5792746A (en) 1998-08-11
PL179261B1 (pl) 2000-08-31
BR9406009A (pt) 1995-12-26
US5378804A (en) 1995-01-03
PL310634A1 (en) 1995-12-27
IL108892A (en) 1998-07-15

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