ES2139043T3 - Compuestos de azaciclohexapeptidos. - Google Patents

Compuestos de azaciclohexapeptidos.

Info

Publication number
ES2139043T3
ES2139043T3 ES94200604T ES94200604T ES2139043T3 ES 2139043 T3 ES2139043 T3 ES 2139043T3 ES 94200604 T ES94200604 T ES 94200604T ES 94200604 T ES94200604 T ES 94200604T ES 2139043 T3 ES2139043 T3 ES 2139043T3
Authority
ES
Spain
Prior art keywords
azaciclohexapeptidos
compounds
ceretain
cyclohexapeptide
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES94200604T
Other languages
English (en)
Inventor
James M Balkovec
Frances Aileen Bouffard
Regina M Black
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
Priority to US08/032,847 priority Critical patent/US5378804A/en
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Application granted granted Critical
Publication of ES2139043T3 publication Critical patent/ES2139043T3/es
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2139043(T3) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Anticipated expiration legal-status Critical
Application status is Expired - Lifetime legal-status Critical

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL, OR TOILET PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • YGENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10STECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00Peptide or protein sequence
    • Y10S930/01Peptide or protein sequence
    • Y10S930/27Cyclic peptide or cyclic protein

Abstract

COMPUESTOS DE CERETAIN AZO CICLOHEXAPEPTIDO SE HAN ENCONTRADO PARA TENER PROPIEDADES ANTIBIOTICAS SUPERIORES. NUEVOS PROCESOS PARA SU PREPARACION TAMBIEN SE DESCRIBEN.
ES94200604T 1993-03-16 1994-03-09 Compuestos de azaciclohexapeptidos. Expired - Lifetime ES2139043T3 (es)

Priority Applications (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
ES2139043T3 true ES2139043T3 (es) 2000-02-01

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
ES94200604T Expired - Lifetime ES2139043T3 (es) 1993-03-16 1994-03-09 Compuestos de azaciclohexapeptidos.

Country Status (31)

Country Link
US (3) US5378804A (es)
EP (1) EP0620232B1 (es)
JP (1) JP2568474B2 (es)
CN (1) CN1098274C (es)
AT (1) AT186736T (es)
AU (1) AU668804B2 (es)
BG (1) BG63047B1 (es)
BR (2) BR9406009A (es)
CA (1) CA2118757C (es)
CZ (1) CZ286235B6 (es)
DE (2) DE10299013I2 (es)
DK (1) DK0620232T3 (es)
ES (1) ES2139043T3 (es)
FI (1) FI109542B (es)
GR (1) GR3031872T3 (es)
HK (1) HK1008674A1 (es)
HR (1) HRP940161B1 (es)
HU (2) HU217614B (es)
IL (1) IL108892A (es)
LU (1) LU90875I2 (es)
LV (1) LV12574B (es)
NL (1) NL300076I2 (es)
NO (2) NO318372B1 (es)
NZ (1) NZ263360A (es)
PL (1) PL179261B1 (es)
RO (1) RO113246B1 (es)
RU (1) RU2122548C1 (es)
SI (1) SI9420013B (es)
SK (1) SK282527B6 (es)
WO (1) WO1994021677A1 (es)
ZA (1) ZA9401807B (es)

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US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
DK0779895T3 (da) * 1994-08-23 2000-03-13 Merck & Co Inc Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
AT223226T (de) * 1994-09-16 2002-09-15 Merck & Co Inc Azazyklohexapeptid-verbindungen
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
JP2966936B2 (ja) * 1995-01-26 1999-10-25 メルク エンド カンパニー インコーポレーテッド 新規抗真菌シクロヘキサペプチド
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
PE63998A1 (es) * 1996-04-19 1998-10-30 Merck & Co Inc Composiciones anti-fungosas
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
EE03748B1 (et) * 1996-09-12 2002-06-17 Merck & Co., Inc. Pneumokandiinderivaat kasutamiseks seenhaiguste ravis
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
EP1490090A4 (en) 2002-02-22 2006-09-20 New River Pharmaceuticals Inc Active agent delivery systems and methods for protecting and administering active agents
US7166572B1 (en) * 1999-07-27 2007-01-23 Aventis Pharma Deutschland Gmbh Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
AT381957T (de) * 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
WO2005080423A1 (en) * 2004-02-24 2005-09-01 Commonwealth Scientific And Industrial Research Organisation Antifungal peptides
EP1785432A1 (en) 2005-11-15 2007-05-16 Sandoz AG Process and intermediates for the synthesis of caspofungin.
CA2657817C (en) * 2006-07-26 2016-05-31 Sandoz Ag Caspofungin formulations
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
US20100137197A1 (en) * 2007-06-26 2010-06-03 Sachin Mittal Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
EP2240507A2 (en) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Processes for preparing high purity aza cyclohexapeptides
US20090324635A1 (en) * 2008-06-25 2009-12-31 Ferenc Korodi Caspofungin free of caspofungin impurity A
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TWI374894B (es) * 2008-12-31 2012-10-21
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (en) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司;上海医药工业研究院 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
PT2618814T (pt) 2010-09-20 2016-10-06 Xellia Pharmaceuticals Aps Composição de caspofungina
US8927690B2 (en) * 2010-09-29 2015-01-06 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
EP2623611B1 (en) * 2010-09-30 2016-07-13 Shanghai Techwell Biopharmaceutical Co., Ltd Method for purifying cyclic lipopeptide or salt thereof
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
CA2826086A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CA3053850A1 (en) 2011-03-03 2012-09-07 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
BR112013026868A2 (pt) 2011-04-28 2016-09-06 Unitris Biopharma Co Ltd intermediário para a síntese de caspofungina e método para o seu preparo
MX2014011299A (es) 2012-03-19 2015-05-11 Cidara Therapeutics Inc Regimenes de dosificacion para compuestos de la clase de las equinocandinas.
SI2922530T1 (sl) * 2012-11-20 2017-04-26 Fresenius Kabi Usa, Llc Formulacije kaspofugin acetata
CN105481952A (zh) * 2014-12-24 2016-04-13 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
WO2017034961A1 (en) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
WO2017120471A1 (en) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities

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DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
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NZ299314A (en) * 1992-03-19 2001-09-28 Lilly Co Eli Cyclic peptide for inhibiting parasitic and antifungal activity
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US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
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Also Published As

Publication number Publication date
HUT73496A (en) 1996-08-28
NL300076I1 (nl) 2002-03-01
NL300076I2 (nl) 2002-04-02
RO113246B1 (ro) 1998-05-29
FI109542B (fi) 2002-08-30
SI9420013A (en) 1996-08-31
IL108892D0 (en) 1994-06-24
CZ286235B6 (cs) 2000-02-16
EP0620232B1 (en) 1999-11-17
HU217614B (hu) 2000-03-28
BR1100273A (pt) 1999-10-13
CA2118757A1 (en) 1994-09-17
FI954327D0 (es)
GR3031872T3 (en) 2000-02-29
FI954327A0 (fi) 1995-09-14
LU90875A9 (es)
NO2005020I1 (no) 2005-09-13
BG63047B1 (bg) 2001-02-28
RU2122548C1 (ru) 1998-11-27
CN1098274C (zh) 2003-01-08
DE69421639T2 (de) 2000-06-08
NO318372B1 (no) 2005-03-14
NO953648L (no) 1995-11-15
DK620232T3 (es)
ZA9401807B (en) 1994-10-13
CZ235895A3 (en) 1996-02-14
DK0620232T3 (da) 2000-03-13
AT186736T (de) 1999-12-15
FI954327A (fi) 1995-09-14
US5378804A (en) 1995-01-03
JP2568474B2 (ja) 1997-01-08
HRP940161B1 (en) 2001-04-30
NO953648D0 (no) 1995-09-15
PL310634A1 (en) 1995-12-27
FI109542B1 (es)
LV12574B (en) 2001-04-20
CA2118757C (en) 2002-05-14
HU9502703D0 (en) 1995-11-28
HRP940161A2 (en) 1996-08-31
EP0620232A1 (en) 1994-10-19
BR9406009A (pt) 1995-12-26
JPH06321986A (ja) 1994-11-22
IL108892A (en) 1998-07-15
AU5783294A (en) 1994-09-22
BG99999A (bg) 1996-04-30
HU211890A9 (en) 1995-12-28
SK113695A3 (en) 1996-02-07
US5514650A (en) 1996-05-07
US5792746A (en) 1998-08-11
DE10299013I1 (de) 2003-01-23
DE69421639D1 (de) 1999-12-23
LV12574A (en) 2000-11-20
KR960701092A (ko) 1996-02-24
SK282527B6 (sk) 2002-10-08
AU668804B2 (en) 1996-05-16
NO2005020I2 (no) 2008-12-01
LU90875I2 (en) 2002-03-04
CN1119441A (zh) 1996-03-27
PL179261B1 (en) 2000-08-31
SI9420013B (sl) 2002-12-31
NZ263360A (en) 1997-08-22
HK1008674A1 (en) 2000-07-07
WO1994021677A1 (en) 1994-09-29
DE10299013I2 (de) 2009-11-19

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