DE10299013I2 - Aza-Zyklohexapeptide - Google Patents

Aza-Zyklohexapeptide

Info

Publication number
DE10299013I2
DE10299013I2 DE10299013C DE10299013C DE10299013I2 DE 10299013 I2 DE10299013 I2 DE 10299013I2 DE 10299013 C DE10299013 C DE 10299013C DE 10299013 C DE10299013 C DE 10299013C DE 10299013 I2 DE10299013 I2 DE 10299013I2
Authority
DE
Germany
Prior art keywords
aza
zyklohexapeptide
ceretain
found
preparation
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
DE10299013C
Other languages
English (en)
Other versions
DE10299013I1 (de
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Merck and Co Inc
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=DE10299013(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Publication of DE10299013I1 publication Critical patent/DE10299013I1/de
Application granted granted Critical
Publication of DE10299013I2 publication Critical patent/DE10299013I2/de
Active legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Chemical Vapour Deposition (AREA)
DE10299013C 1993-03-16 1994-03-09 Aza-Zyklohexapeptide Active DE10299013I2 (de)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (2)

Publication Number Publication Date
DE10299013I1 DE10299013I1 (de) 2003-01-23
DE10299013I2 true DE10299013I2 (de) 2009-11-19

Family

ID=21867140

Family Applications (2)

Application Number Title Priority Date Filing Date
DE10299013C Active DE10299013I2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide
DE69421639T Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Family Applications After (1)

Application Number Title Priority Date Filing Date
DE69421639T Expired - Lifetime DE69421639T2 (de) 1993-03-16 1994-03-09 Aza-Zyklohexapeptide

Country Status (33)

Country Link
US (3) US5378804A (de)
EP (1) EP0620232B1 (de)
JP (1) JP2568474B2 (de)
KR (1) KR100329693B1 (de)
CN (1) CN1098274C (de)
AT (1) ATE186736T1 (de)
AU (1) AU668804B2 (de)
BG (1) BG63047B1 (de)
BR (2) BR9406009A (de)
CA (1) CA2118757C (de)
CZ (1) CZ286235B6 (de)
DE (2) DE10299013I2 (de)
DK (1) DK0620232T3 (de)
ES (1) ES2139043T3 (de)
FI (1) FI109542B (de)
GR (1) GR3031872T3 (de)
HK (1) HK1008674A1 (de)
HR (1) HRP940161B1 (de)
HU (2) HU217614B (de)
IL (1) IL108892A (de)
LU (1) LU90875I2 (de)
LV (1) LV12574B (de)
NL (1) NL300076I2 (de)
NO (2) NO318372B1 (de)
NZ (1) NZ263360A (de)
PL (1) PL179261B1 (de)
RO (1) RO113246B1 (de)
RU (1) RU2122548C1 (de)
SI (1) SI9420013B (de)
SK (1) SK282527B6 (de)
UA (1) UA59329C2 (de)
WO (1) WO1994021677A1 (de)
ZA (1) ZA941807B (de)

Families Citing this family (63)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
CA2195975C (en) * 1994-08-23 2001-05-15 James M. Balkovec An improved process for preparing side chain derivatives of cyclohexapeptidyl lipopeptides
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
ES2181790T3 (es) * 1994-09-16 2003-03-01 Merck & Co Inc Compuestos azaciclohexapeptidicos.
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
AU691743B2 (en) * 1995-01-26 1998-05-21 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU707664B2 (en) * 1995-11-09 1999-07-15 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
USRE38984E1 (en) * 1996-09-12 2006-02-14 Merck & Co., Inc. Antifungal combination therapy
DK0925070T3 (da) * 1996-09-12 2003-12-01 Merck & Co Inc Antifungal kombinationsterapi
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
US7166572B1 (en) * 1999-07-27 2007-01-23 Aventis Pharma Deutschland Gmbh Cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
ATE381957T1 (de) * 2003-07-22 2008-01-15 Theravance Inc Verwendung eines antimykotischen echinocandin- mittels in kombination mit einem antibakteriellen glycopeptid-mittel
CA2557333A1 (en) * 2004-02-24 2005-09-01 Commonwealth Scientific And Industrial Research Organisation Antifungal peptides
EP1785432A1 (de) 2005-11-15 2007-05-16 Sandoz AG Verfahren und Zwischenprodukte zur Synthese des Caspofungins
KR101536781B1 (ko) * 2006-07-26 2015-07-14 산도즈 아게 카스포펀진 제형
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
WO2009002481A1 (en) 2007-06-26 2008-12-31 Merck & Co., Inc. Lyophilized anti-fungal composition
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
WO2009142761A1 (en) * 2008-05-21 2009-11-26 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungin bo free of caspofungin co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
KR20110011704A (ko) * 2008-06-25 2011-02-08 테바 기오기스제르갸르 자르트쾨렌 뮈쾨되 레스즈베니타르사사그 카스포펀진 불순물 ａ를 함유하지 않는 카스포펀진
US20100256074A1 (en) * 2008-06-25 2010-10-07 Chaim Eidelman Processes for preparing high purity aza cyclohexapeptides
WO2010064219A1 (en) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Process for the preparation of a novel intermediate for caspofungin
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (en) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Crystalline compound
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
US20120190815A1 (en) * 2009-08-06 2012-07-26 Tianhui Xu Azacyclohexapeptide or its pharmaceutical acceptable salt, preparing method and use thereof
US8751760B2 (en) * 2009-10-01 2014-06-10 Dell Products L.P. Systems and methods for power state transitioning in an information handling system
CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
DK2618814T3 (en) 2010-09-20 2016-10-10 Xellia Pharmaceuticals Aps Caspofunginsammensætning
CA2813330A1 (en) * 2010-09-29 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or the salts thereof
CA2813335A1 (en) * 2010-09-30 2012-04-05 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclolipopeptide compounds or salts thereof
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
KR101331984B1 (ko) 2010-12-09 2013-11-25 종근당바이오 주식회사 카스포펀진 제조방법 및 그의 신규 중간체
WO2012093293A1 (en) * 2011-01-03 2012-07-12 Biocon Limited Process for preparation of caspofungin acetate and intermediates
CN102618606B (zh) * 2011-01-30 2014-09-10 浙江海正药业股份有限公司 一种棘白菌素生物转化方法
CN103889221B (zh) 2011-03-03 2016-08-31 西蔡德制药公司 抗真菌剂及其应用
CN102746384B (zh) 2011-04-22 2016-01-20 上海天伟生物制药有限公司 一种高纯度的卡泊芬净或其盐及其制备方法和用途
TWI597293B (zh) 2011-04-28 2017-09-01 江蘇盛迪醫藥有限公司 用於合成卡帕芬淨的中間體及其製備方法
KR102061486B1 (ko) 2012-03-19 2020-01-03 시다라 세라퓨틱스, 인코포레이티드 에키노칸딘 계열의 화합물에 대한 투여 용법
HUE032392T2 (en) 2012-11-20 2017-09-28 Fresenius Kabi Usa Llc Kaszpofunginacetát compositions
CN112110991A (zh) * 2014-12-24 2020-12-22 上海天伟生物制药有限公司 一种含氮杂环六肽前体的组合物及其制备方法和用途
WO2017034961A1 (en) 2015-08-21 2017-03-02 Trilogy Therapeutics, Inc. Methods of treating lung infection with caspofungin
WO2017120471A1 (en) 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
CN109154603A (zh) 2016-03-16 2019-01-04 奇达拉治疗公司 用于治疗真菌感染的给药方案
WO2017185030A1 (en) * 2016-04-22 2017-10-26 Fresenius Kabi Usa, Llc Caspofungin formulation with low impurities
WO2019014333A1 (en) 2017-07-12 2019-01-17 Cidara Therapeutics, Inc. COMPOSITIONS AND METHODS FOR THE TREATMENT OF FUNGAL INFECTIONS
WO2019157453A1 (en) 2018-02-12 2019-08-15 Trilogy Therapeutics, Inc. Caspofungin compositions for inhalation
EP3620462A1 (de) 2018-09-04 2020-03-11 Xellia Pharmaceuticals ApS Verfahren zur herstellung von caspofungin

Family Cites Families (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
BE851310A (fr) * 1976-02-12 1977-08-10 Sandoz Sa Nouveaux derives de la tetrahydro-equinocandine b
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
US4293485A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
EP0030844A1 (de) * 1979-12-13 1981-06-24 Eli Lilly And Company Verfahren zur Wiedergewinnung von A-30912-Antibiotika
US4320053A (en) * 1979-12-13 1982-03-16 Eli Lilly And Company Derivatives of A-30912D nucleus
US4287120A (en) * 1979-12-13 1981-09-01 Eli Lilly And Company Derivatives of S31794/F-1 nucleus
US4293489A (en) * 1979-12-13 1981-10-06 Eli Lilly And Company Derivatives of A-30912A nucleus
DE3030554A1 (de) * 1980-08-13 1982-03-25 Chemische Werke Hüls AG, 4370 Marl Einbrennlacke
US4931352A (en) * 1987-10-07 1990-06-05 Merck & Co., Inc. Antifungal fermentation product
US5166135A (en) * 1988-09-12 1992-11-24 Merck & Company, Inc. Method for the control of pneumocystis carinii
DK173802B1 (da) * 1988-09-12 2001-11-05 Merck & Co Inc Præparat til behandling af Pneumocystis carinii infeksioner og anvendelse af et cyclohexapeptid til fremstilling af et lægemiddel mod Pneumocystis carinii infektioner
US5021341A (en) * 1990-03-12 1991-06-04 Merck & Co., Inc. Antibiotic agent produced by the cultivation of Zalerion microorganism in the presence of mannitol
NZ234225A (en) * 1989-06-30 1993-09-27 Merck & Co Inc Antibiotic from zalerion arboricola and its use as an antifungal agent and antipneumocystis agent
US5202309A (en) * 1989-06-30 1993-04-13 Merck & Co., Inc. Antibiotic cyclopeptide fermentation product
US5194377A (en) * 1989-06-30 1993-03-16 Merck & Co., Inc. Antibiotic agent
GB8925593D0 (en) * 1989-11-13 1990-01-04 Fujisawa Pharmaceutical Co Fr901379 substance and preparation thereof
US5159059A (en) * 1990-05-29 1992-10-27 Merck & Co., Inc. Process for reduction of certain cyclohexapeptide compounds
TW264477B (de) * 1992-03-19 1995-12-01 Lilly Co Eli
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
WO1994021677A1 (en) 1994-09-29
EP0620232B1 (de) 1999-11-17
DE10299013I1 (de) 2003-01-23
GR3031872T3 (en) 2000-02-29
DE69421639D1 (de) 1999-12-23
AU668804B2 (en) 1996-05-16
HU217614B (hu) 2000-03-28
BR1100273A (pt) 1999-10-13
NL300076I1 (nl) 2002-03-01
SK282527B6 (sk) 2002-10-08
CA2118757C (en) 2002-05-14
IL108892A0 (en) 1994-06-24
BG99999A (bg) 1996-04-30
KR960701092A (ko) 1996-02-24
NO953648L (no) 1995-11-15
CZ286235B6 (cs) 2000-02-16
BG63047B1 (bg) 2001-02-28
LV12574B (en) 2001-04-20
US5514650A (en) 1996-05-07
NO953648D0 (no) 1995-09-15
EP0620232A1 (de) 1994-10-19
ATE186736T1 (de) 1999-12-15
JPH06321986A (ja) 1994-11-22
CA2118757A1 (en) 1994-09-17
KR100329693B1 (ko) 2002-08-14
SI9420013B (sl) 2002-12-31
NO318372B1 (no) 2005-03-14
FI954327A0 (fi) 1995-09-14
HUT73496A (en) 1996-08-28
RO113246B1 (ro) 1998-05-29
DK0620232T3 (da) 2000-03-13
LU90875I2 (en) 2002-03-04
PL310634A1 (en) 1995-12-27
DE69421639T2 (de) 2000-06-08
HRP940161A2 (en) 1996-08-31
US5378804A (en) 1995-01-03
SK113695A3 (en) 1996-02-07
HU211890A9 (en) 1995-12-28
CZ235895A3 (en) 1996-02-14
ES2139043T3 (es) 2000-02-01
NL300076I2 (nl) 2002-04-02
HK1008674A1 (en) 1999-05-14
NO2005020I2 (no) 2008-12-01
AU5783294A (en) 1994-09-22
HRP940161B1 (en) 2001-04-30
UA59329C2 (uk) 2003-09-15
ZA941807B (en) 1994-10-13
BR9406009A (pt) 1995-12-26
LV12574A (en) 2000-11-20
NO2005020I1 (no) 2005-09-13
FI109542B (fi) 2002-08-30
RU2122548C1 (ru) 1998-11-27
IL108892A (en) 1998-07-15
CN1098274C (zh) 2003-01-08
FI954327A (fi) 1995-09-14
US5792746A (en) 1998-08-11
CN1119441A (zh) 1996-03-27
SI9420013A (en) 1996-08-31
NZ263360A (en) 1997-08-22
JP2568474B2 (ja) 1997-01-08
HU9502703D0 (en) 1995-11-28
PL179261B1 (pl) 2000-08-31

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