PT2680873T - Agentes antifúngicos e suas utilizações - Google Patents

Agentes antifúngicos e suas utilizações

Info

Publication number
PT2680873T
PT2680873T PT127519940T PT12751994T PT2680873T PT 2680873 T PT2680873 T PT 2680873T PT 127519940 T PT127519940 T PT 127519940T PT 12751994 T PT12751994 T PT 12751994T PT 2680873 T PT2680873 T PT 2680873T
Authority
PT
Portugal
Prior art keywords
antifungal agents
antifungal
agents
Prior art date
Application number
PT127519940T
Other languages
English (en)
Inventor
Duke James Kenneth Jr
Patrick Laudeman Christopher
Balkrishna Malkar Navdeep
Radhakrishnan Balasingham
Original Assignee
Cidara Therapeutics Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Cidara Therapeutics Inc filed Critical Cidara Therapeutics Inc
Publication of PT2680873T publication Critical patent/PT2680873T/pt

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/64Cyclic peptides containing only normal peptide links
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00Drugs for disorders of the respiratory system
    • A61P11/02Nasal agents, e.g. decongestants
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00Drugs for disorders of the urinary system
    • A61P13/02Drugs for disorders of the urinary system of urine or of the urinary tract, e.g. urine acidifiers
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00Drugs for genital or sexual disorders; Contraceptives
    • A61P15/02Drugs for genital or sexual disorders; Contraceptives for disorders of the vagina
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00Drugs for dermatological disorders
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10Antimycotics
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00Drugs for disorders of the blood or the extracellular fluid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/60Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation occurring through the 4-amino group of 2,4-diamino-butanoic acid
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/08Peptides having 5 to 11 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pulmonology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Epidemiology (AREA)
  • Immunology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Reproductive Health (AREA)
  • Urology & Nephrology (AREA)
  • Otolaryngology (AREA)
  • Endocrinology (AREA)
  • Hematology (AREA)
  • Diabetes (AREA)
  • Dermatology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
PT127519940T 2011-03-03 2012-03-02 Agentes antifúngicos e suas utilizações PT2680873T (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US201161448807P 2011-03-03 2011-03-03

Publications (1)

Publication Number Publication Date
PT2680873T true PT2680873T (pt) 2017-11-01

Family

ID=46758514

Family Applications (1)

Application Number Title Priority Date Filing Date
PT127519940T PT2680873T (pt) 2011-03-03 2012-03-02 Agentes antifúngicos e suas utilizações

Country Status (20)

Country Link
US (5) US8722619B2 (pt)
EP (2) EP3192803B1 (pt)
JP (4) JP5809296B2 (pt)
CN (2) CN106279369B (pt)
CA (2) CA3053850A1 (pt)
CY (1) CY1119709T1 (pt)
DK (1) DK2680873T3 (pt)
ES (1) ES2645074T3 (pt)
FI (1) FIC20240022I1 (pt)
FR (1) FR24C1027I1 (pt)
HR (1) HRP20171579T8 (pt)
HU (2) HUE036778T2 (pt)
LT (1) LT2680873T (pt)
NL (1) NL301280I2 (pt)
NO (1) NO2680873T3 (pt)
PL (1) PL2680873T3 (pt)
PT (1) PT2680873T (pt)
RS (1) RS56426B1 (pt)
SI (1) SI2680873T1 (pt)
WO (1) WO2012119065A2 (pt)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP3192803B1 (en) 2011-03-03 2020-12-09 Cidara Therapeutics, Inc. Antifungal agents and uses thereof
SI3677252T1 (sl) * 2012-03-19 2024-02-29 Cidara Therapeutics, Inc. Sheme odmerjanja za spojine iz razreda ehinokandinov
US20160213742A1 (en) * 2013-09-04 2016-07-28 Cidara Therapeutics, Inc. Compositions and methods for the treatment of fungal infections
US20170042162A1 (en) * 2014-04-28 2017-02-16 University Of Central Florida Research Foundation, Inc. Compositions, methods of making a composition, and methods of use
WO2016201283A1 (en) * 2015-06-12 2016-12-15 Cidara Therapeutics, Inc. Antifungal agents
WO2017049102A1 (en) * 2015-09-16 2017-03-23 Cidara Therapeutics, Inc. Methods for treating fungal infections
CN106674333B (zh) * 2015-11-06 2020-10-27 博瑞生物医药(苏州)股份有限公司 一种环肽类抗真菌化合物及其制备方法
WO2017120471A1 (en) * 2016-01-08 2017-07-13 Cidara Therapeutics, Inc. Methods for preventing and treating pneumocystis infections
ES2955711T3 (es) * 2016-03-16 2023-12-05 Cidara Therapeutics Inc Regímenes de dosificación para el tratamiento de infecciones fúngicas
WO2018102407A1 (en) * 2016-11-29 2018-06-07 Cidara Therapeutics, Inc Methods for preventing fungal infections
MA47437A (fr) * 2017-01-31 2019-12-11 Cidara Therapeutics Inc Procédés de traitement d'infections fongiques
MA49576A (fr) 2017-07-12 2021-04-07 Cidara Therapeutics Inc Compositions et méthodes pour le traitement d'infections fongiques
JP7373508B2 (ja) * 2018-06-15 2023-11-02 シダラ セラピューティクス インコーポレーテッド エキノカンジン抗真菌剤の合成
WO2020086931A1 (en) * 2018-10-25 2020-04-30 Cidara Therapeutics, Inc. Polymorph of echinocandin antifungal agent
AU2020397311A1 (en) 2019-12-06 2022-07-14 Jiangsu Hengrui Medicine Co., Ltd. Echinocandin analogues and preparation method therefor
US20240262866A1 (en) 2021-06-03 2024-08-08 Shanghai Senhui Medicine Co., Ltd. Method for preparing anidulafungin derivative
CN116903706B (zh) * 2023-06-13 2024-05-17 深圳市祥根生物有限公司 一种棘白菌素类药物及其制备方法和用途

Family Cites Families (25)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6030944A (en) * 1991-10-01 2000-02-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compounds
US5399552A (en) 1991-10-17 1995-03-21 Merck & Co, Inc Antibiotic peptides bearing aminoalkylthioether moieties
US5378804A (en) 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US6268338B1 (en) 1993-04-30 2001-07-31 Merck & Co., Inc. Cyclohexapeptidyl amine compounds
US5948753A (en) 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
CA2161149A1 (en) * 1993-05-04 1994-11-10 James M. Balkovec Cyclohexapeptidyl aminoalkyl ethers
AU7874494A (en) * 1993-09-22 1995-04-10 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5541160A (en) * 1994-04-04 1996-07-30 Merck & Co., Inc. Antifungal and anti-pneumocystis compounds, compositions containing such compounds, and methods of use
US5514651A (en) 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516756A (en) 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
EP0805685B1 (en) 1995-01-26 2001-09-26 Merck & Co., Inc. Novel antifungal cyclohexapeptides
US5652213A (en) * 1995-05-26 1997-07-29 Eli Lilly And Company Cyclic peptide antifungal agents
CN1337968A (zh) * 1998-12-09 2002-02-27 伊莱利利公司 蓝刺菌素环肽化合物的纯化
US6248363B1 (en) 1999-11-23 2001-06-19 Lipocine, Inc. Solid carriers for improved delivery of active ingredients in pharmaceutical compositions
JP2002538097A (ja) 1999-03-03 2002-11-12 イーライ リリー アンド カンパニー 薬学的経口ecb処方物および組成物の作製方法
US6610822B2 (en) 2000-09-01 2003-08-26 Merck & Co., Inc. Purification process
US6991800B2 (en) 2002-06-13 2006-01-31 Vicuron Pharmaceuticals Inc. Antifungal parenteral products
EP1654036B1 (en) * 2003-07-22 2007-12-26 Theravance, Inc. Use of an echinocandin antifungal agent in combination with a glycopeptide antibacterial agent
WO2007113386A1 (en) * 2006-03-31 2007-10-11 Karyon-Ctt Ltd Peptide conjugates
US20090238867A1 (en) 2007-12-13 2009-09-24 Scott Jenkins Nanoparticulate Anidulafungin Compositions and Methods for Making the Same
GB0817121D0 (en) 2008-09-18 2008-10-29 Univ St Andrews Anti-fungal therapy
SI2427477T1 (sl) * 2009-05-07 2014-06-30 Dsm Sinochem Pharmaceuticals Netherlands B.V. Postopek priprave ciklopeptidov
JP2013503179A (ja) 2009-08-27 2013-01-31 シーチェイド ファーマシューティカルズ,インコーポレーテッド エキノキャンディン誘導体
US9561285B2 (en) 2010-01-22 2017-02-07 Ascendis Pharma As Carrier-linked carbamate prodrug linkers
EP3192803B1 (en) 2011-03-03 2020-12-09 Cidara Therapeutics, Inc. Antifungal agents and uses thereof

Also Published As

Publication number Publication date
PL2680873T3 (pl) 2018-01-31
CN103889221A (zh) 2014-06-25
NO2680873T3 (pt) 2018-01-06
DK2680873T3 (en) 2017-10-30
EP3192803A1 (en) 2017-07-19
JP6111447B2 (ja) 2017-04-12
CA2865791A1 (en) 2012-09-07
WO2012119065A2 (en) 2012-09-07
SI2680873T1 (sl) 2017-12-29
US20170253635A1 (en) 2017-09-07
US9676821B2 (en) 2017-06-13
US20160075740A1 (en) 2016-03-17
FIC20240022I1 (fi) 2024-06-19
EP2680873A2 (en) 2014-01-08
JP5809296B2 (ja) 2015-11-10
US20220162263A1 (en) 2022-05-26
ES2645074T8 (es) 2018-09-28
NL301280I2 (nl) 2024-08-01
HRP20171579T1 (hr) 2018-02-09
LT2680873T (lt) 2017-11-27
CN106279369A (zh) 2017-01-04
WO2012119065A3 (en) 2014-03-13
US20150024997A1 (en) 2015-01-22
US20130244930A1 (en) 2013-09-19
HUE036778T2 (hu) 2018-07-30
JP2016029052A (ja) 2016-03-03
JP2014516339A (ja) 2014-07-10
CY1119709T1 (el) 2018-06-27
CA2865791C (en) 2019-10-08
FR24C1027I1 (fr) 2024-08-30
ES2645074T3 (es) 2017-12-04
JP6302108B2 (ja) 2018-03-28
JP2017132770A (ja) 2017-08-03
US9217014B2 (en) 2015-12-22
US8722619B2 (en) 2014-05-13
CN106279369B (zh) 2020-02-11
EP2680873A4 (en) 2015-08-26
RS56426B1 (sr) 2018-01-31
EP3192803B1 (en) 2020-12-09
HRP20171579T8 (hr) 2018-12-14
CA3053850A1 (en) 2012-09-07
CN103889221B (zh) 2016-08-31
HUS2400021I1 (hu) 2024-07-28
EP2680873B1 (en) 2017-08-09
JP2018118977A (ja) 2018-08-02

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