LU90875I2 - Aza-cyclohexapeptides - Google Patents

Aza-cyclohexapeptides

Info

Publication number
LU90875I2
LU90875I2 LU90875C LU90875C LU90875I2 LU 90875 I2 LU90875 I2 LU 90875I2 LU 90875 C LU90875 C LU 90875C LU 90875 C LU90875 C LU 90875C LU 90875 I2 LU90875 I2 LU 90875I2
Authority
LU
Luxembourg
Prior art keywords
aza
cyclohexapeptides
ceretain
found
preparation
Prior art date
Application number
LU90875C
Other languages
English (en)
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=21867140&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=LU90875(I2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Publication of LU90875I2 publication Critical patent/LU90875I2/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/08—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis for Pneumocystis carinii
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S930/00—Peptide or protein sequence
    • Y10S930/01—Peptide or protein sequence
    • Y10S930/27—Cyclic peptide or cyclic protein

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Communicable Diseases (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Oncology (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • Genetics & Genomics (AREA)
  • Molecular Biology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Chemical Vapour Deposition (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
LU90875C 1993-03-16 2002-01-03 Aza-cyclohexapeptides LU90875I2 (en)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US08/032,847 US5378804A (en) 1993-03-16 1993-03-16 Aza cyclohexapeptide compounds

Publications (1)

Publication Number Publication Date
LU90875I2 true LU90875I2 (en) 2002-03-04

Family

ID=21867140

Family Applications (1)

Application Number Title Priority Date Filing Date
LU90875C LU90875I2 (en) 1993-03-16 2002-01-03 Aza-cyclohexapeptides

Country Status (33)

Country Link
US (3) US5378804A (fr)
EP (1) EP0620232B1 (fr)
JP (1) JP2568474B2 (fr)
KR (1) KR100329693B1 (fr)
CN (1) CN1098274C (fr)
AT (1) ATE186736T1 (fr)
AU (1) AU668804B2 (fr)
BG (1) BG63047B1 (fr)
BR (2) BR9406009A (fr)
CA (1) CA2118757C (fr)
CZ (1) CZ286235B6 (fr)
DE (2) DE69421639T2 (fr)
DK (1) DK0620232T3 (fr)
ES (1) ES2139043T3 (fr)
FI (1) FI109542B (fr)
GR (1) GR3031872T3 (fr)
HK (1) HK1008674A1 (fr)
HR (1) HRP940161B1 (fr)
HU (2) HU217614B (fr)
IL (1) IL108892A (fr)
LU (1) LU90875I2 (fr)
LV (1) LV12574B (fr)
NL (1) NL300076I2 (fr)
NO (2) NO318372B1 (fr)
NZ (1) NZ263360A (fr)
PL (1) PL179261B1 (fr)
RO (1) RO113246B1 (fr)
RU (1) RU2122548C1 (fr)
SI (1) SI9420013B (fr)
SK (1) SK282527B6 (fr)
UA (1) UA59329C2 (fr)
WO (1) WO1994021677A1 (fr)
ZA (1) ZA941807B (fr)

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US5874403A (en) * 1992-10-15 1999-02-23 Merck & Co., Inc. Amino acid conjugates of cyclohexapeptidyl amines
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5948753A (en) * 1993-05-04 1999-09-07 Merck & Co., Inc. Cyclohexapeptidyl propanolamine compounds
DK0779895T3 (da) * 1994-08-23 2000-03-13 Merck & Co Inc Forbedret fremgangsmåde til fremstilling af sidekædederivater af cyclohexapeptidyl-lipopeptider
AU692308B2 (en) * 1994-09-16 1998-06-04 Merck Sharp & Dohme Corp. Aza cyclohexapeptide compounds
US5514651A (en) * 1994-09-16 1996-05-07 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds
JP2966936B2 (ja) * 1995-01-26 1999-10-25 メルク エンド カンパニー インコーポレーテッド 新規抗真菌シクロヘキサペプチド
US5552521A (en) * 1995-02-10 1996-09-03 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
CA2235824A1 (fr) * 1995-11-09 1997-05-15 Merck & Co., Inc. Compose de cyclohexapeptidyle bisamine, compositions contenant ce compose et procedes d'utilisation
US5952300A (en) * 1996-04-19 1999-09-14 Merck & Co., Inc. Antifungal compositions
AR006598A1 (es) * 1996-04-19 1999-09-08 Merck Sharp & Dohme "composiciones anti-fungosas, su uso en la manufactura de medicamentos y un procedimiento para su preparación"
HRP970318B1 (en) * 1996-06-14 2002-06-30 Merck & Co Inc A process for preparing certain aza cyclohexapeptides
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
ATE248625T1 (de) * 1996-09-12 2003-09-15 Merck & Co Inc Fungizide kombinationstherapie
US5854212A (en) * 1996-10-23 1998-12-29 Merck & Co., Inc. Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
US5936062A (en) * 1997-06-12 1999-08-10 Merck & Co., Inc. Process for preparing certain aza cyclohexapeptides
AU6564000A (en) * 1999-07-27 2001-02-13 Aventis Pharma Deutschland Gmbh Novel cyclohexapeptide compounds, processes for their production and their use as a pharmaceutical
AR035808A1 (es) * 2001-04-12 2004-07-14 Merck & Co Inc Proceso de deshidratacion capaz de minimizar la epimerizacion de un grupo hidroxilo por ciertas equinocandinas
AU2003217676B2 (en) 2002-02-22 2009-06-11 Takeda Pharmaceutical Company Limited Active agent delivery systems and methods for protecting and administering active agents
US7214768B2 (en) * 2002-04-08 2007-05-08 Merck & Co., Inc. Echinocandin process
WO2005018743A1 (fr) * 2003-07-22 2005-03-03 Theravance, Inc. Utilisation d'un agent antifongique a base d'echinocandines conjointement avec un agent antibacterien glycopeptidique
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EP1785432A1 (fr) 2005-11-15 2007-05-16 Sandoz AG Procédé et produits intermédiaires pour la synthèse du caspofungin.
JP5373606B2 (ja) * 2006-07-26 2013-12-18 サンド・アクチエンゲゼルシヤフト カスポファンギン製剤
TW200826957A (en) * 2006-10-16 2008-07-01 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Purification processes for echinocandin-type compounds
CA2692053A1 (fr) * 2007-06-26 2008-12-31 Merck Sharp & Dohme Corp. Composition antifongique lyophilisee
US20090075870A1 (en) * 2007-09-17 2009-03-19 Protia, Llc Deuterium-enriched caspofungin
US20090291996A1 (en) * 2008-05-21 2009-11-26 Ferenc Korodi Caspofungin free of caspofungin Co
US8048853B2 (en) * 2008-06-13 2011-11-01 Xellia Pharmaceuticals Aps Process for preparing pharmaceutical compound and intermediates thereof
WO2009158034A1 (fr) * 2008-06-25 2009-12-30 Teva Gyogyszergyar Zartkoruen Mukodo Reszvenytarsasag Caspofungine débarrassée de l'impureté a des caspofungines
EP2240507A2 (fr) * 2008-06-25 2010-10-20 TEVA Gyógyszergyár Zártkörüen Müködö Részvénytársaság Procédés pour préparer des azacyclohexapeptides de pureté élevée
WO2010064219A1 (fr) 2008-12-04 2010-06-10 Ranbaxy Laboratories Limited Procédé de préparation d'un nouvel intermédiaire de la caspofungine
TW201024322A (en) * 2008-12-31 2010-07-01 Chunghwa Chemical Synthesis & Biotech Co Ltd Preparation method for nitrogen containing heterocyclic hexapeptide with high conversion rate
WO2010108637A1 (fr) 2009-03-27 2010-09-30 Axellia Pharmaceuticals Aps Composé cristallisé
CN101602795B (zh) * 2009-07-20 2011-12-21 中国人民解放军第二军医大学 环六脂肽胺类抗真菌化合物及其盐类和制备方法
EP2463293A4 (fr) * 2009-08-06 2013-06-05 Shanghai Techwell Biopharm Co Azacyclohexapeptide ou son sel pharmaceutiquement acceptable, procédé de préparation et utilisation afférente
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CN101792486A (zh) * 2010-04-12 2010-08-04 浙江海正药业股份有限公司 一种合成醋酸卡泊芬净的方法
CN102219832B (zh) * 2010-04-15 2013-08-21 上海天伟生物制药有限公司 一种氮杂环六肽或其盐的纯化方法
RU2013114993A (ru) 2010-09-20 2014-10-27 Кселлия Фармасьютикалз Апс Композиция каспофунгина
AU2011307731B2 (en) * 2010-09-29 2016-02-18 Shanghai Techwell Biopharmaceutical Co., Ltd. Process for purifying cyclic lipopeptide compounds or salts thereof
RU2538274C2 (ru) * 2010-09-30 2015-01-10 Шанхай Техвелл Биофармасьютикал Ко., Лтд. Способ очистки циклопептидных соединений или их солей
CN102367268B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其用途
CN102367269B (zh) 2010-11-10 2013-11-06 上海天伟生物制药有限公司 一种卡泊芬净类似物及其制备方法和用途
CN102367267B (zh) 2010-11-10 2013-09-04 上海天伟生物制药有限公司 一种卡泊芬净的制备方法
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EP2661441A4 (fr) * 2011-01-03 2015-04-08 Biocon Ltd Procédé de préparation d'acétate de caspofungine et de ses intermédiaires
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HUE032392T2 (en) * 2012-11-20 2017-09-28 Fresenius Kabi Usa Llc Kaszpofunginacetát compositions
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DE2704030A1 (de) * 1976-02-12 1977-08-18 Sandoz Ag Neue organische verbindungen, ihre herstellung und verwendung
DE2742435A1 (de) * 1976-09-28 1978-04-06 Sandoz Ag Aminoalkylaether der peptide tetrahydro- sl 7810/f-ii, s 31794/f-1, aculeacin a und tetrahydroechinocandin b, ihre verwendung und herstellung
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IL105048A (en) * 1992-03-19 2001-06-14 Eli Lilly And Company U S Antifungal substances of the cyclic peptide type and a process for their preparation
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds
US5516757A (en) * 1994-09-16 1996-05-14 Merck & Co., Inc. Semi-synthetic lipopeptides, compositions containing said lipopeptides, and methods of use
US5516756A (en) * 1994-10-31 1996-05-14 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
BR1100273A (pt) 1999-10-13
KR100329693B1 (ko) 2002-08-14
JPH06321986A (ja) 1994-11-22
NL300076I1 (nl) 2002-03-01
WO1994021677A1 (fr) 1994-09-29
HK1008674A1 (en) 1999-05-14
ATE186736T1 (de) 1999-12-15
DE69421639D1 (de) 1999-12-23
IL108892A0 (en) 1994-06-24
LV12574A (en) 2000-11-20
CA2118757A1 (fr) 1994-09-17
KR960701092A (ko) 1996-02-24
LV12574B (en) 2001-04-20
CN1098274C (zh) 2003-01-08
PL310634A1 (en) 1995-12-27
NL300076I2 (nl) 2002-04-02
RO113246B1 (ro) 1998-05-29
ES2139043T3 (es) 2000-02-01
NO2005020I1 (no) 2005-09-13
DE69421639T2 (de) 2000-06-08
SK113695A3 (en) 1996-02-07
BG63047B1 (bg) 2001-02-28
AU5783294A (en) 1994-09-22
PL179261B1 (pl) 2000-08-31
JP2568474B2 (ja) 1997-01-08
EP0620232B1 (fr) 1999-11-17
HRP940161A2 (en) 1996-08-31
FI109542B (fi) 2002-08-30
HU9502703D0 (en) 1995-11-28
BG99999A (bg) 1996-04-30
HRP940161B1 (en) 2001-04-30
ZA941807B (en) 1994-10-13
NZ263360A (en) 1997-08-22
CZ286235B6 (cs) 2000-02-16
NO953648L (no) 1995-11-15
SI9420013A (en) 1996-08-31
CZ235895A3 (en) 1996-02-14
HU217614B (hu) 2000-03-28
HU211890A9 (en) 1995-12-28
US5514650A (en) 1996-05-07
FI954327A (fi) 1995-09-14
NO318372B1 (no) 2005-03-14
AU668804B2 (en) 1996-05-16
NO953648D0 (no) 1995-09-15
DK0620232T3 (da) 2000-03-13
EP0620232A1 (fr) 1994-10-19
UA59329C2 (uk) 2003-09-15
BR9406009A (pt) 1995-12-26
US5378804A (en) 1995-01-03
HUT73496A (en) 1996-08-28
GR3031872T3 (en) 2000-02-29
NO2005020I2 (no) 2008-12-01
SI9420013B (sl) 2002-12-31
CA2118757C (fr) 2002-05-14
DE10299013I1 (de) 2003-01-23
CN1119441A (zh) 1996-03-27
DE10299013I2 (de) 2009-11-19
US5792746A (en) 1998-08-11
FI954327A0 (fi) 1995-09-14
IL108892A (en) 1998-07-15
SK282527B6 (sk) 2002-10-08
RU2122548C1 (ru) 1998-11-27

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