ATE248625T1 - Fungizide kombinationstherapie - Google Patents

Fungizide kombinationstherapie

Info

Publication number
ATE248625T1
ATE248625T1 AT97941495T AT97941495T ATE248625T1 AT E248625 T1 ATE248625 T1 AT E248625T1 AT 97941495 T AT97941495 T AT 97941495T AT 97941495 T AT97941495 T AT 97941495T AT E248625 T1 ATE248625 T1 AT E248625T1
Authority
AT
Austria
Prior art keywords
inhibitors
antifungal
combination therapy
combination
xmp
Prior art date
Application number
AT97941495T
Other languages
English (en)
Inventor
Kenneth F Bartizal
George K Abruzzo
Amy M Flattery
Original Assignee
Merck & Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GBGB9620739.4A external-priority patent/GB9620739D0/en
Application filed by Merck & Co Inc filed Critical Merck & Co Inc
Application granted granted Critical
Publication of ATE248625T1 publication Critical patent/ATE248625T1/de

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K45/00—Medicinal preparations containing active ingredients not provided for in groups A61K31/00 - A61K41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/04—Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/12—Cyclic peptides, e.g. bacitracins; Polymyxins; Gramicidins S, C; Tyrocidins A, B or C
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides
    • A61K38/16—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • A61K38/1703—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • A61K38/1709—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • A61K38/1751—Bactericidal/permeability-increasing protein [BPI]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Engineering & Computer Science (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Immunology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Marine Sciences & Fisheries (AREA)
  • Zoology (AREA)
  • Molecular Biology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Agricultural Chemicals And Associated Chemicals (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
AT97941495T 1996-09-12 1997-09-09 Fungizide kombinationstherapie ATE248625T1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US2632796P 1996-09-12 1996-09-12
GBGB9620739.4A GB9620739D0 (en) 1996-10-04 1996-10-04 Antifungal combination therapy
PCT/US1997/015987 WO1998010782A1 (en) 1996-09-12 1997-09-09 Antifungal combination therapy

Publications (1)

Publication Number Publication Date
ATE248625T1 true ATE248625T1 (de) 2003-09-15

Family

ID=26310166

Family Applications (1)

Application Number Title Priority Date Filing Date
AT97941495T ATE248625T1 (de) 1996-09-12 1997-09-09 Fungizide kombinationstherapie

Country Status (21)

Country Link
EP (1) EP0925070B1 (de)
JP (1) JP3288051B2 (de)
KR (1) KR100380871B1 (de)
CN (1) CN1235554A (de)
AT (1) ATE248625T1 (de)
AU (1) AU721334B2 (de)
CA (1) CA2265824C (de)
CY (1) CY2481B1 (de)
CZ (1) CZ88499A3 (de)
DE (1) DE69724626T2 (de)
DK (1) DK0925070T3 (de)
EA (1) EA002469B1 (de)
EE (1) EE03748B1 (de)
ES (1) ES2203819T3 (de)
IL (1) IL128870A0 (de)
NO (1) NO991207L (de)
NZ (1) NZ334446A (de)
PL (1) PL333282A1 (de)
PT (1) PT925070E (de)
SK (1) SK29999A3 (de)
WO (1) WO1998010782A1 (de)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP0753001B1 (de) * 1994-11-08 1999-09-08 Glaxo Wellcome S.A. Antifungale sordaridin-derivate
US6069126A (en) * 1996-09-12 2000-05-30 Merck & Co., Inc. Antifungal combination therapy
AUPQ066399A0 (en) * 1999-05-31 1999-06-24 Fujisawa Pharmaceutical Co., Ltd. Antifungal combination use
AUPQ462399A0 (en) * 1999-12-13 2000-01-13 Fujisawa Pharmaceutical Co., Ltd. New use
KR100680464B1 (ko) * 2000-06-28 2007-02-08 주식회사 하이닉스반도체 반도체 소자의 캐패시터 제조 방법
WO2002098463A1 (fr) * 2001-06-05 2002-12-12 The New Industry Research Organization Compositions antifongiques
PL1867332T3 (pl) 2005-04-07 2012-01-31 Toyama Chemical Co Ltd Kompozycja farmaceutyczna i sposób sterowania środka przeciwgrzybiczego w kombinacji
TWI385169B (zh) 2005-10-31 2013-02-11 Eisai R&D Man Co Ltd 經雜環取代之吡啶衍生物及含有彼之抗真菌劑
CA2664915C (en) 2006-10-06 2014-01-07 Toyoma Chemical Co., Ltd. Pharmaceutical composition comprising phenylamidine derivative and method of using the pharmaceutical composition in combination with antifungal agent
TWI426918B (zh) * 2007-02-12 2014-02-21 Merck Sharp & Dohme Ｉｌ-２３拮抗劑於治療感染之用途
US20110076240A1 (en) * 2008-04-18 2011-03-31 Day Donal F Antifungal and Anti-Cariogenic Cellobio-Oligosaccharides Produced by Dextransucrase
CN102274217B (zh) * 2010-06-10 2013-04-10 吉林大学 三氯生作为抗真菌药物氟康唑增效剂的新用途
CN102274216B (zh) * 2010-06-10 2013-04-10 吉林大学 一种提高氟康唑抗真菌作用的增效剂
CN102274215B (zh) * 2010-06-10 2013-04-10 吉林大学 一种具有与氟康唑协同抗真菌作用的增效剂
US20130288956A1 (en) 2010-11-05 2013-10-31 Eisai R&D Management Co., Ltd. Combined pharmaceutical composition as antifungal agent
US8623813B2 (en) * 2011-05-24 2014-01-07 Bayer Cropscience Lp Synergistic combinations of polyene fungicides and non-ribosomal peptides and related methods of use
CN102319326A (zh) * 2011-07-23 2012-01-18 李玮 一种治疗脚癣的浸药卫生纸
CN114652836B (zh) * 2022-03-25 2023-06-20 山东大学 T3ss小分子抑制剂及其筛选方法和应用
CN116473985A (zh) * 2023-03-29 2023-07-25 暨南大学 一种多烯类抗真菌药物组合物及其应用

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5378804A (en) * 1993-03-16 1995-01-03 Merck & Co., Inc. Aza cyclohexapeptide compounds

Also Published As

Publication number Publication date
NO991207D0 (no) 1999-03-11
IL128870A0 (en) 2000-06-01
KR100380871B1 (ko) 2003-04-18
ES2203819T3 (es) 2004-04-16
EE03748B1 (et) 2002-06-17
EA199900283A1 (ru) 1999-08-26
NO991207L (no) 1999-05-11
CA2265824C (en) 2004-11-09
NZ334446A (en) 2000-11-24
CZ88499A3 (cs) 1999-10-13
SK29999A3 (en) 2000-02-14
JP3288051B2 (ja) 2002-06-04
AU721334B2 (en) 2000-06-29
EA002469B1 (ru) 2002-06-27
DE69724626T2 (de) 2004-07-29
WO1998010782A1 (en) 1998-03-19
EP0925070B1 (de) 2003-09-03
PT925070E (pt) 2003-12-31
AU4339297A (en) 1998-04-02
DK0925070T3 (da) 2003-12-01
KR20000036054A (ko) 2000-06-26
CN1235554A (zh) 1999-11-17
CA2265824A1 (en) 1998-03-19
PL333282A1 (en) 1999-11-22
EE9900088A (et) 1999-10-15
DE69724626D1 (de) 2003-10-09
EP0925070A1 (de) 1999-06-30
JP2000503675A (ja) 2000-03-28
CY2481B1 (en) 2005-06-03

Similar Documents

Publication Publication Date Title
ATE248625T1 (de) Fungizide kombinationstherapie
Rousey et al. Low-dose amphotericin B prophylaxis against invasive Aspergillus infections in allogeneic marrow transplantation
Bernard et al. A trial of antioxidants N-acetylcysteine and procysteine in ARDS
Galgiani Fluconazole, a new antifungal agent
Meis et al. Current management of fungal infections
WO2000072865A3 (en) Antifungal combination use
ATE365487T1 (de) Verbesserungen an und bezüglich verstellbaren stühlen und betten
US6069126A (en) Antifungal combination therapy
BR0211970A (pt) Uso de bibn4096 em combinação com outras drogas antienxaqueca para o tratamento de enxaqueca
AR001834A1 (es) Empleo de una combinación de productos activos en la fabricación del cuero agente microbicida que contiene dichos productos activos procedimiento parala protección de pieles animales y del cuero cont ra el ataque microbiano empleo de dicha combinación para la obtención de agentes
Macura The Influence of Some Antifungal Drugs on In Vitro Adherence of Candida albicans to Human Buccal Epithelial Cells: Der Einfluß einiger Antimyzetika auf die Adhärenz von Candida albicans in vitro an Epithelzellen der Mundschleimhaut des Menschen
DE69813833D1 (de) 4-cyano-4-deformylsordarizin-derivate
IT1297538B1 (it) Enteroclisma di lattulosio/lattitolo con o senza aggiunta di neomicina per la cura della encefalopatia portosistemica acuta
ATE241979T1 (de) 4-cyano-4-deformylsordarinderivate
FI944017A0 (fi) Makrolidien sokerijohdannaiset
MXPA99002401A (en) Antifungal combination therapy
Calandra et al. Response to van Saene et al.'s comment on" Prevention of severe Candida infections in non-neutropenic, high-risk, critically ill patients"
UCHIDA et al. Studies on the Antifungal Activities of 5-Flurocytosine 4. In Vitro and In Vivo Antitungal Activities against Dematiaceous Fungi
BR0000161A (pt) Composição adequada para a inibição do crescimento de fungos, e, uso da combinação de um primeiro ingrediente que inibe a biogenese da parede da célula de um fungo normal e um segundo ingrediente que pode perturbar a estrutura da membrana celular do referido fungo.
IT226486Z2 (it) Trapunta coperta o plaid e simili con tasca per l'introduzione delle gambe
AU9530101A (en) Medicinal composition and in particular its use in fluid therapy

Legal Events

Date Code Title Description
UEP Publication of translation of european patent specification

Ref document number: 0925070

Country of ref document: EP

EEFA Change of the company name