CA2197209C - Composes de type azacyclohexapeptide - Google Patents

Composes de type azacyclohexapeptide Download PDF

Info

Publication number
CA2197209C
CA2197209C CA002197209A CA2197209A CA2197209C CA 2197209 C CA2197209 C CA 2197209C CA 002197209 A CA002197209 A CA 002197209A CA 2197209 A CA2197209 A CA 2197209A CA 2197209 C CA2197209 C CA 2197209C
Authority
CA
Canada
Prior art keywords
compound
pharmaceutically acceptable
acid addition
addition salt
acceptable acid
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Fee Related
Application number
CA002197209A
Other languages
English (en)
Other versions
CA2197209A1 (fr
Inventor
James M. Balkovec
Frances A. Bouffard
Milton L. Hammond
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Individual
Original Assignee
Merck and Co Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Merck and Co Inc filed Critical Merck and Co Inc
Priority claimed from PCT/US1995/011520 external-priority patent/WO1996008266A1/fr
Publication of CA2197209A1 publication Critical patent/CA2197209A1/fr
Application granted granted Critical
Publication of CA2197209C publication Critical patent/CA2197209C/fr
Anticipated expiration legal-status Critical
Expired - Fee Related legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K7/00—Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/50—Cyclic peptides containing at least one abnormal peptide link
    • C07K7/54—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring
    • C07K7/56—Cyclic peptides containing at least one abnormal peptide link with at least one abnormal peptide link in the ring the cyclisation not occurring through 2,4-diamino-butanoic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Biochemistry (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Composés représentés par la formule (I) (Seq ID Nos. 1-6), dans laquelle tous les substituants sont entièrement définis. Ces composés sont utiles comme agents antibiotiques et antifongiques, ainsi que dans le traitement et la prévention des infections à Pneumocystis.
CA002197209A 1994-09-16 1995-09-12 Composes de type azacyclohexapeptide Expired - Fee Related CA2197209C (fr)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US30797994A 1994-09-16 1994-09-16
US307,979 1994-09-16
PCT/US1995/011520 WO1996008266A1 (fr) 1994-09-16 1995-09-12 Composes azacyclohexapeptides

Publications (2)

Publication Number Publication Date
CA2197209A1 CA2197209A1 (fr) 1996-03-21
CA2197209C true CA2197209C (fr) 2007-04-10

Family

ID=38007174

Family Applications (1)

Application Number Title Priority Date Filing Date
CA002197209A Expired - Fee Related CA2197209C (fr) 1994-09-16 1995-09-12 Composes de type azacyclohexapeptide

Country Status (1)

Country Link
CA (1) CA2197209C (fr)

Also Published As

Publication number Publication date
CA2197209A1 (fr) 1996-03-21

Similar Documents

Publication Publication Date Title
CA2118757C (fr) Composes a base d'azacyclohexapeptide
EP0805685B1 (fr) Nouveaux cyclohexapeptides antifongiques
US5516756A (en) Aza cyclohexapeptide compounds
AU692308B2 (en) Aza cyclohexapeptide compounds
CA2079171C (fr) Composes a base de cyclohexapeptidylpropanolamine
US5514651A (en) Aza cyclohexapeptide compounds
US5399552A (en) Antibiotic peptides bearing aminoalkylthioether moieties
US5914313A (en) 1- 4-hydroxy-5-aminoethyloxy-N2 -(10,12-dimethyl-1-oxotetradecyl)ornithine!-5-(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandin B, other aminoalkyl derivatives and salts thereof
CA2197209C (fr) Composes de type azacyclohexapeptide
CA2080756A1 (fr) 1-¬4-hydroxy-5-aminoethyloxy-n2-(10,12-dimethyl-1-oxotetraecyl)ornithine|-5(3-hydroxyglutamine)-6-(3-hydroxyproline)echinocandine
US5854212A (en) Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
AU707664B2 (en) Cyclohexapeptidyl bisamine compound, compositions containing said compound and methods of use
CA2145203A1 (fr) Conjugues aminoacides de cyclohexapeptidylamines

Legal Events

Date Code Title Description
EEER Examination request
MKLA Lapsed

Effective date: 20150914