FI106965B - Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi - Google Patents

Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi Download PDF

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Publication number
FI106965B
FI106965B FI941730A FI941730A FI106965B FI 106965 B FI106965 B FI 106965B FI 941730 A FI941730 A FI 941730A FI 941730 A FI941730 A FI 941730A FI 106965 B FI106965 B FI 106965B
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FI
Finland
Prior art keywords
adipoyl
dna
gene
expandase
strain
Prior art date
Application number
FI941730A
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English (en)
Finnish (fi)
Swedish (sv)
Other versions
FI941730A0 (fi
FI941730A (fi
Inventor
Michael J Conder
Lorilee Crawford
Phyllis C Mcada
John A Rambosek
Anthony Michael Stepan
Christopher D Reeves
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of FI941730A0 publication Critical patent/FI941730A0/fi
Publication of FI941730A publication Critical patent/FI941730A/fi
Application granted granted Critical
Publication of FI106965B publication Critical patent/FI106965B/fi

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
FI941730A 1991-10-15 1994-04-14 Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi FI106965B (fi)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US77783391 1991-10-15
US95349292A 1992-10-06 1992-10-06
US95349292 1992-10-06
PCT/US1992/008585 WO1993008287A1 (en) 1991-10-15 1992-10-08 Novel bioprocesses for preparing 7-aca and 7-adac
US9208585 1992-10-08

Publications (3)

Publication Number Publication Date
FI941730A0 FI941730A0 (fi) 1994-04-14
FI941730A FI941730A (fi) 1994-04-14
FI106965B true FI106965B (fi) 2001-05-15

Family

ID=27119363

Family Applications (1)

Application Number Title Priority Date Filing Date
FI941730A FI106965B (fi) 1991-10-15 1994-04-14 Uusia biologisia menetelmiä 7-ACA:n ja 7-ADAC:n valmistamiseksi

Country Status (27)

Country Link
US (4) US5559005A (sk)
EP (2) EP0540210B1 (sk)
JP (1) JP2655790B2 (sk)
KR (1) KR100227711B1 (sk)
CN (1) CN1074484A (sk)
AT (2) ATE216700T1 (sk)
AU (1) AU657800B2 (sk)
BG (1) BG62261B1 (sk)
CA (1) CA2080573C (sk)
CZ (1) CZ288721B6 (sk)
DE (2) DE69227750T2 (sk)
DK (2) DK0540210T3 (sk)
ES (2) ES2127205T3 (sk)
FI (1) FI106965B (sk)
GR (1) GR3029343T3 (sk)
HU (1) HU219370B (sk)
IL (3) IL103419A (sk)
MX (1) MX9205902A (sk)
NO (1) NO315802B1 (sk)
NZ (1) NZ244714A (sk)
RO (1) RO116648B1 (sk)
RU (1) RU2002130702A (sk)
SK (1) SK280569B6 (sk)
TW (1) TW272233B (sk)
UA (1) UA47385C2 (sk)
WO (1) WO1993008287A1 (sk)
YU (1) YU48930B (sk)

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US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
DE3789880T2 (de) * 1986-01-31 1994-09-08 Beecham Group Plc Isolierung und Expression von bei der Biosynthese von Beta-Laktamen beteiligten Genen.
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
BR9407104A (pt) * 1993-07-30 1996-08-27 Gist Brocades Nv Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido
HU219259B (en) * 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca, recombinant dna vectrors and transformed host cells
ATE334203T1 (de) * 1994-09-28 2006-08-15 Novozymes As Verfahren zur herstellung von sekundären metaboliten
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
KR100421225B1 (ko) * 1995-06-02 2004-06-18 디에스엠 기스트 베.파우. 페니실린g상에서의익스팬다제활성에의한7-adca의제조방법
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
JP2000514301A (ja) 1996-07-16 2000-10-31 ギスト ブロカデス ベスローテン フェンノートシャップ アクレモニウム・クリソゲヌムを用いたセファロスポリンの新規な調製方法
KR20000022108A (ko) * 1997-04-22 2000-04-25 한스 발터 라벤 탈아실화된 세팔로스포린의 발효제조방법
RO120653B1 (ro) 1997-04-22 2006-05-30 Gist-Brocades B.V. Procedeu îmbunătăţit pentru preparare de cefalosporine
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
JP2000512512A (ja) * 1997-04-22 2000-09-26 ギスト ブロカデス ベスローテン フェンノートシャップ 脱アシル化セファロスポリンの発酵による製造方法
AU9264598A (en) * 1997-08-22 1999-03-16 Gist-Brocades B.V. Statin production by fermentation
ATE226954T1 (de) 1998-03-27 2002-11-15 Dsm Nv Verfahren zur fermentativen herstellung von cephalosporin
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
JP2002533092A (ja) * 1998-12-22 2002-10-08 デーエスエム・ナムローゼ・フェンノートシャップ セファロスポリンの改良されたｉｎｖｉｖｏ産生
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KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
EP2585608B1 (en) 2010-06-22 2017-07-26 DSM Sinochem Pharmaceuticals Netherlands B.V. Air bubble fermentation process
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101808192B1 (ko) * 2016-08-26 2018-01-18 아미코젠주식회사 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

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Also Published As

Publication number Publication date
CA2080573C (en) 2004-01-06
HU219370B (en) 2001-03-28
DK0856516T3 (da) 2002-07-29
SK43194A3 (en) 1996-11-06
NZ244714A (en) 1994-03-25
IL103419A (en) 2003-06-24
IL133734A0 (en) 2001-04-30
US6017726A (en) 2000-01-25
JPH06113884A (ja) 1994-04-26
BG98714A (bg) 1995-02-28
YU92592A (sh) 1995-10-03
SK280569B6 (sk) 2000-03-13
KR100227711B1 (ko) 1999-12-01
EP0540210A1 (en) 1993-05-05
CZ88494A3 (en) 1995-03-15
RU2002130702A (ru) 2004-05-20
EP0856516B1 (en) 2002-04-24
EP0856516A1 (en) 1998-08-05
HUT69783A (en) 1995-09-28
UA47385C2 (uk) 2002-07-15
FI941730A0 (fi) 1994-04-14
RO116648B1 (ro) 2001-04-30
CN1074484A (zh) 1993-07-21
FI941730A (fi) 1994-04-14
NO941345L (no) 1994-06-15
TW272233B (sk) 1996-03-11
DE69232581D1 (de) 2002-05-29
DE69227750D1 (de) 1999-01-14
GR3029343T3 (en) 1999-05-28
ATE216700T1 (de) 2002-05-15
WO1993008287A1 (en) 1993-04-29
YU48930B (sh) 2002-12-10
IL103419A0 (en) 1993-03-15
BG62261B1 (bg) 1999-06-30
AU657800B2 (en) 1995-03-23
ES2127205T3 (es) 1999-04-16
US5629171A (en) 1997-05-13
NO315802B1 (no) 2003-10-27
MX9205902A (es) 1994-06-30
US5559005A (en) 1996-09-24
DE69232581T2 (de) 2002-11-14
IL133733A0 (en) 2001-04-30
CA2080573A1 (en) 1993-04-16
AU2701692A (en) 1993-04-22
JP2655790B2 (ja) 1997-09-24
US6071713A (en) 2000-06-06
ES2176613T3 (es) 2002-12-01
HU9401073D0 (en) 1994-07-28
DK0540210T3 (da) 1999-06-23
NO941345D0 (no) 1994-04-14
EP0540210B1 (en) 1998-12-02
CZ288721B6 (cs) 2001-08-15
ATE174057T1 (de) 1998-12-15
DE69227750T2 (de) 1999-04-22

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Owner name: GIST-BROCADES B.V.

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