ES2176613T3 - Acido adipoil-7-amino-desacetil-cefalosporanico. - Google Patents
Acido adipoil-7-amino-desacetil-cefalosporanico.Info
- Publication number
- ES2176613T3 ES2176613T3 ES97204046T ES97204046T ES2176613T3 ES 2176613 T3 ES2176613 T3 ES 2176613T3 ES 97204046 T ES97204046 T ES 97204046T ES 97204046 T ES97204046 T ES 97204046T ES 2176613 T3 ES2176613 T3 ES 2176613T3
- Authority
- ES
- Spain
- Prior art keywords
- adipoyl
- side chain
- acid
- aca
- amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Expired - Lifetime
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/0004—Oxidoreductases (1.)
- C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/10—Transferases (2.)
- C12N9/1025—Acyltransferases (2.3)
- C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
- C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
- Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y10S435/00—Chemistry: molecular biology and microbiology
- Y10S435/8215—Microorganisms
- Y10S435/911—Microorganisms using fungi
- Y10S435/933—Penicillium
- Y10S435/935—Penicillium chrysogenum
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Medicinal Chemistry (AREA)
- Molecular Biology (AREA)
- Biomedical Technology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Enzymes And Modification Thereof (AREA)
- Cephalosporin Compounds (AREA)
- Saccharide Compounds (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
- Medicinal Preparation (AREA)
Abstract
SE PREPARA EL ACIDO 7 - AMINOCEFALOSPORANICO (7 - ACA) Y EL ACIDO 7 - AMINODESACETILCEFALOSPORANICO (7 - ADAC), IMPORTANTES INTERMEDIOS PARA PREPARAR ANTIBIOTICOS DE CEFALOSPORINA, MEDIANTE UN NUEVO BIOPROCEDIMIENTO EN EL CUAL UNA CEPA TRANSFORMADA DE PENICILLIUM CHRYSOGENUM SE CULTIVA EN PRESENCIA DE UN CULTIVO DE DESARROLLO DE ADIPATO PARA PRODUCIR ADIPOIL - 6 - APA (ACIDO 6 AMINOPENICILANICO); SEGUIDO DE LA EXPRESION IN SITU DE LOS SIGUIENTES GENES CON LOS CUALES HA SIDO TRANSFORMADO EL P. CHRYSOGENUM: 1) UN GEN DE EXPANDASA, POR EJEMPLO PROCEDENTE DE CEPHALOSPORIUM ACREMONIUM, CUYO PRODUCTO DE EXPRESION CONVIERTE EL ADIPOIL - 6 APA MEDIANTE LA EXPANSION DEL ANILLO EN ADIPOIL - 7 - ADCA; 2) UN GEN DE HIDROXILASA CUYO PRODUCTO DE EXPRESION CONVIERTE LA CADENA LATERAL 3 - METILO DEL ADIPOIL 7 - ADCA EN 3 HIDROXIMETILO, PARA PRODUCIR EL PRIMER PRODUCTO, ACIDO ADIPOIL 7 - AMINODESACETILCEFALOSPORANICO (7 - ADAC); Y 3) UN GEN DE ACETILTRANSFERASA CUYO PRODUCTO DE EXPRESION CONVIERTE LA CADENALATERAL 3 - HIDROXIMETILO EN LA CADENA LATERAL 3 - ACETILOXIMETILO DEL ADIPOIL - 7 - ACA. EL PRODUCTO FINAL, 7 - ACA, SE PREPARA ENTONCES MEDIANTE ESCISION DE LA CADENA LATERAL ADIPOILO UTILIZANDO UNA ADIPOILO ACILASA. POR CONSIGUIENTE, LA SINTESIS COMPLETA SE LLEVA A CABO UTILIZANDO BIOPROCEDIMIENTOS, Y RESULTA EFICAZ Y ECONOMICA.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US77783391A | 1991-10-15 | 1991-10-15 | |
US95349292A | 1992-10-06 | 1992-10-06 |
Publications (1)
Publication Number | Publication Date |
---|---|
ES2176613T3 true ES2176613T3 (es) | 2002-12-01 |
Family
ID=27119363
Family Applications (2)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92309351T Expired - Lifetime ES2127205T3 (es) | 1991-10-15 | 1992-10-14 | Nuevo bioproceso para preparar 7-aca y 7-adac. |
ES97204046T Expired - Lifetime ES2176613T3 (es) | 1991-10-15 | 1992-10-14 | Acido adipoil-7-amino-desacetil-cefalosporanico. |
Family Applications Before (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
ES92309351T Expired - Lifetime ES2127205T3 (es) | 1991-10-15 | 1992-10-14 | Nuevo bioproceso para preparar 7-aca y 7-adac. |
Country Status (27)
Country | Link |
---|---|
US (4) | US5559005A (es) |
EP (2) | EP0856516B1 (es) |
JP (1) | JP2655790B2 (es) |
KR (1) | KR100227711B1 (es) |
CN (1) | CN1074484A (es) |
AT (2) | ATE174057T1 (es) |
AU (1) | AU657800B2 (es) |
BG (1) | BG62261B1 (es) |
CA (1) | CA2080573C (es) |
CZ (1) | CZ288721B6 (es) |
DE (2) | DE69232581T2 (es) |
DK (2) | DK0856516T3 (es) |
ES (2) | ES2127205T3 (es) |
FI (1) | FI106965B (es) |
GR (1) | GR3029343T3 (es) |
HU (1) | HU219370B (es) |
IL (3) | IL103419A (es) |
MX (1) | MX9205902A (es) |
NO (1) | NO315802B1 (es) |
NZ (1) | NZ244714A (es) |
RO (1) | RO116648B1 (es) |
RU (1) | RU2002130702A (es) |
SK (1) | SK280569B6 (es) |
TW (1) | TW272233B (es) |
UA (1) | UA47385C2 (es) |
WO (1) | WO1993008287A1 (es) |
YU (1) | YU48930B (es) |
Families Citing this family (34)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6709859B1 (en) | 1986-01-31 | 2004-03-23 | Beecham Group P.L.C. | Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression |
EP0233715B1 (en) * | 1986-01-31 | 1994-05-25 | BEECHAM GROUP plc | Isolation and expression of genes involved in the biosynthesis of beta-lactams |
KR0171897B1 (ko) * | 1989-12-27 | 1999-02-01 | 후지사와 도모끼찌로 | 7-아미노세펨 화합물 또는 그 염류의 제조 방법 |
US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
BR9407104A (pt) * | 1993-07-30 | 1996-08-27 | Gist Brocades Nv | Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido |
CN1103814C (zh) * | 1993-07-30 | 2003-03-26 | 吉斯特·布罗卡迪斯公司 | 通过2-(羧乙硫基)乙酰-7-adca和3-(羧甲硫基)丙酰-7-adca有效生产7-adca的方法 |
US5882883A (en) * | 1994-09-28 | 1999-03-16 | Novo Nordisk A/S | Process for the production of secondary metabolites |
DE4437420A1 (de) * | 1994-10-19 | 1996-04-25 | Hoechst Ag | Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase |
BR9608954A (pt) * | 1995-06-02 | 1999-03-02 | Gist Brocades Bv | Processo para a produção de 7-adca via atividade de expandase na penicilina g |
US5731165A (en) * | 1995-06-02 | 1998-03-24 | Gist-Brocades, B.V. | Process for the production of 7-ADCA via expandase activity on penicillin G |
WO1997038107A1 (en) * | 1996-04-04 | 1997-10-16 | Gist-Brocades B.V. | An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof |
EP0914463A2 (en) | 1996-07-16 | 1999-05-12 | Gist-Brocades B.V. | NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM) |
DE69828940T2 (de) | 1997-04-22 | 2005-12-29 | Dsm Ip Assets B.V. | Verbessertes verfahren zur fermentativen herstellung von cephalosporin |
ZA983396B (en) * | 1997-04-22 | 1998-10-27 | Gist Brocades Bv | A method for controlling the solubility of a beta-lactam nucleus |
US6518039B2 (en) * | 1997-04-22 | 2003-02-11 | Dsm N.V. | Process for the fermentative production of deacylated cephalosporins |
DE69811039T2 (de) * | 1997-04-22 | 2004-01-22 | Dsm N.V. | Verfahren für die fermentative produktion von deazylierten cephalosporinen. |
WO1999010499A1 (en) * | 1997-08-22 | 1999-03-04 | Dsm N.V. | Statin production by fermentation |
ES2186347T3 (es) | 1998-03-27 | 2003-05-01 | Dsm Nv | Nuevo procedimiento de produccion por fermentacion de cefalosporina. |
US6383773B2 (en) | 1998-04-23 | 2002-05-07 | Massachusetts Institute Of Technology | Penicillin conversion |
CN1331751A (zh) * | 1998-12-22 | 2002-01-16 | Dsm公司 | 改进的头孢菌素的体内生产方法 |
ES2165276B1 (es) * | 1999-06-18 | 2003-03-01 | Antibioticos Sau | Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc) |
CN1222528C (zh) | 2000-05-13 | 2005-10-12 | 史密斯克莱·比奇曼公司 | 提纯克拉布兰酸盐的方法 |
US6699699B2 (en) * | 2002-03-26 | 2004-03-02 | Synmax Biochemical Co., Ltd. | Mutated penicillin expandases |
KR20060061295A (ko) * | 2003-05-28 | 2006-06-07 | 디에스엠 아이피 어셋츠 비.브이. | 세펨 화합물 |
CN101389635B (zh) * | 2006-02-23 | 2013-03-06 | 中化帝斯曼制药有限公司荷兰公司 | 改进的头孢菌素生产 |
KR101569832B1 (ko) * | 2008-11-19 | 2015-11-18 | 삼성전자주식회사 | 시료 중의 게놈 dna 및 플라스미드 dna를 서로 분리하는 방법 및 그를 위한 키트 |
CN101429538B (zh) * | 2008-12-12 | 2011-05-25 | 河北九派制药有限公司 | 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法 |
WO2010115838A1 (en) | 2009-04-03 | 2010-10-14 | Dsm Ip Assets B.V. | Fermentation process |
US8863444B2 (en) | 2010-05-31 | 2014-10-21 | Feature Walters | Assembly system for modular building units |
CN103003439A (zh) | 2010-06-22 | 2013-03-27 | 中化帝斯曼制药有限公司荷兰公司 | 气泡发酵工艺 |
EP2614066B1 (en) | 2010-09-07 | 2017-11-29 | DSM Sinochem Pharmaceuticals Netherlands B.V. | Process for the production of cephalosporins |
CN102702229A (zh) * | 2011-08-04 | 2012-10-03 | 重庆天地药业有限责任公司 | 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备 |
WO2015091455A1 (en) | 2013-12-17 | 2015-06-25 | Dpx Holdings B.V. | Bioreactor |
KR101808192B1 (ko) * | 2016-08-26 | 2018-01-18 | 아미코젠주식회사 | 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주 |
Family Cites Families (35)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
FR1270852A (fr) * | 1960-09-20 | 1961-09-01 | Bayer Ag | Procédé d'acylation enzymatique d'acide 6-aminopénicillanique |
FR2241557A1 (en) * | 1973-08-22 | 1975-03-21 | Aries Robert | 7-Amino-desacetoxy cephalosporanic acid prepn - from cephalosporin C, using an amido hydrolase enzyme |
JPS5417032B2 (es) * | 1974-01-23 | 1979-06-27 | ||
JPS5282791A (en) * | 1975-12-27 | 1977-07-11 | Toyo Jozo Co Ltd | Preparation of 7-amino compounds |
JPS5920360B2 (ja) * | 1976-04-19 | 1984-05-12 | 萬有製薬株式会社 | 7−アミノセフアロスポラン酸および其の誘導体の製造法 |
JPS5386094A (en) * | 1977-01-06 | 1978-07-29 | Banyu Pharmaceut Co Ltd | Preparation of 7-amino-cephem derivatives |
US4178210A (en) * | 1977-03-07 | 1979-12-11 | Massachusetts Institute Of Technology | Accellular synthesis of cephalosporins |
US4248966A (en) * | 1979-05-17 | 1981-02-03 | Massachusetts Institute Of Technology | Synthesis of isopenicillin derivatives in the absence of living cells |
US4307192A (en) * | 1979-05-17 | 1981-12-22 | Massachusetts Institute Of Technology | Cell-free synthesis of deacetoxycephalosporin C |
US4536476A (en) * | 1982-08-23 | 1985-08-20 | Queen's University At Kingston | Stable epimerase reagent, cyclase reagent and ring expansion reagent for cell-free production of cephalosporins |
US4510246A (en) * | 1982-08-23 | 1985-04-09 | Queen's University At Kingston | Isolation of cyclase, epimerase and a ring expansion enzyme for producing unnatural cephalosporins |
JPS60110292A (ja) * | 1983-11-22 | 1985-06-15 | Asahi Chem Ind Co Ltd | セフアロスポリン・アシラ−ゼ産生遺伝情報を担うdνa断片 |
JPS6121097A (ja) * | 1984-07-10 | 1986-01-29 | Asahi Chem Ind Co Ltd | 7−アミノセフアロスポラン酸及びその誘導体の製造法 |
FR2569723B1 (fr) * | 1984-08-31 | 1986-09-19 | Centre Nat Rech Scient | Application des antibiotiques de la famille des phleomycines a titre d'agent de selection dans le domaine du genie genetique |
JPS61152286A (ja) * | 1984-12-27 | 1986-07-10 | Asahi Chem Ind Co Ltd | セフアロスポリンcアシラ−ゼ産生遺伝情報を担うdna断片 |
EP0233715B1 (en) * | 1986-01-31 | 1994-05-25 | BEECHAM GROUP plc | Isolation and expression of genes involved in the biosynthesis of beta-lactams |
US4753881A (en) * | 1986-09-10 | 1988-06-28 | Eli Lilly And Company | Purified enzyme and process therefor |
JPH0829114B2 (ja) * | 1986-09-18 | 1996-03-27 | 旭化成工業株式会社 | 7−アミノセフアロスポラン酸およびその誘導体の製造法 |
HUT43644A (en) * | 1986-11-17 | 1987-11-30 | Univ Oxford | Process for producing 3-substituted-cephalosporines |
ATE90382T1 (de) * | 1987-01-17 | 1993-06-15 | Hoechst Ag | Verwendung von gamma-glutamyl-transpeptidase. |
IL85535A (en) * | 1987-03-04 | 1994-02-27 | Lilly Co Eli | AND Recombinant expression vectors encoding datastoxysplosporin C synthetase and datacetylsephalosporin C synthetase |
US4981789A (en) * | 1987-03-18 | 1991-01-01 | Merck & Co., Inc. | One-step enzymatic conversion of cephalosporin C and derivatives to 7-aminocephalosporanic acid and derivatives |
DE3743323A1 (de) * | 1987-12-21 | 1989-06-29 | Hoechst Ag | Verfahren zur enzymatischen hydrolyse von (alpha)-aminoadipinyl-monoaminoverbindungen |
EP0322032A3 (en) * | 1987-12-21 | 1991-01-30 | Merck & Co. Inc. | One-step enzymatic conversion of cephalosporin c and derivatives to 7-aminocephalosporanic acid and derivatives |
US5070020A (en) * | 1988-05-09 | 1991-12-03 | Eli Lilly And Company | Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase |
US5082772A (en) * | 1988-10-24 | 1992-01-21 | Eli Lilly And Company | Process for preparing deacetylcephalosporin c |
JP2928884B2 (ja) * | 1989-02-01 | 1999-08-03 | 武田薬品工業株式会社 | Dnaおよびその用途 |
CA2049958A1 (en) * | 1989-04-04 | 1990-10-05 | Bing L. Wong | Enzymatic production of 7-amino cephalosporanic acid |
US5104800A (en) * | 1989-06-27 | 1992-04-14 | Merck & Co., Inc. | One-step cephalosporin c amidase enzyme |
IL95766A (en) * | 1989-09-27 | 1996-12-05 | Lilly Co Eli | Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity |
KR0171897B1 (ko) * | 1989-12-27 | 1999-02-01 | 후지사와 도모끼찌로 | 7-아미노세펨 화합물 또는 그 염류의 제조 방법 |
DE69131238T2 (de) * | 1990-01-12 | 1999-11-11 | Glaxo Group Ltd | Für ein Enzym der Antibiotika-Biosynthese kodierende DNA-Sequenz |
JPH03254684A (ja) * | 1990-03-02 | 1991-11-13 | Asahi Chem Ind Co Ltd | 新規cDNA化合物 |
CA2045951A1 (en) * | 1990-07-06 | 1992-01-07 | Steven Kovacevic | Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity |
US5318896A (en) * | 1991-09-11 | 1994-06-07 | Merck & Co., Inc. | Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA) |
-
1992
- 1992-10-08 CZ CZ1994884A patent/CZ288721B6/cs not_active IP Right Cessation
- 1992-10-08 HU HU9401073A patent/HU219370B/hu not_active IP Right Cessation
- 1992-10-08 UA UA94005496A patent/UA47385C2/uk unknown
- 1992-10-08 RO RO94-00603A patent/RO116648B1/ro unknown
- 1992-10-08 KR KR1019940701210A patent/KR100227711B1/ko not_active IP Right Cessation
- 1992-10-08 WO PCT/US1992/008585 patent/WO1993008287A1/en active IP Right Grant
- 1992-10-08 SK SK431-94A patent/SK280569B6/sk unknown
- 1992-10-13 NZ NZ244714A patent/NZ244714A/en not_active IP Right Cessation
- 1992-10-14 AU AU27016/92A patent/AU657800B2/en not_active Ceased
- 1992-10-14 CA CA002080573A patent/CA2080573C/en not_active Expired - Fee Related
- 1992-10-14 DK DK97204046T patent/DK0856516T3/da active
- 1992-10-14 AT AT92309351T patent/ATE174057T1/de not_active IP Right Cessation
- 1992-10-14 IL IL10341992A patent/IL103419A/xx not_active IP Right Cessation
- 1992-10-14 MX MX9205902A patent/MX9205902A/es not_active IP Right Cessation
- 1992-10-14 DE DE69232581T patent/DE69232581T2/de not_active Expired - Fee Related
- 1992-10-14 ES ES92309351T patent/ES2127205T3/es not_active Expired - Lifetime
- 1992-10-14 EP EP97204046A patent/EP0856516B1/en not_active Expired - Lifetime
- 1992-10-14 AT AT97204046T patent/ATE216700T1/de not_active IP Right Cessation
- 1992-10-14 EP EP92309351A patent/EP0540210B1/en not_active Expired - Lifetime
- 1992-10-14 DK DK92309351T patent/DK0540210T3/da active
- 1992-10-14 DE DE69227750T patent/DE69227750T2/de not_active Expired - Fee Related
- 1992-10-14 ES ES97204046T patent/ES2176613T3/es not_active Expired - Lifetime
- 1992-10-14 CN CN92113331A patent/CN1074484A/zh active Pending
- 1992-10-15 YU YU92592A patent/YU48930B/sh unknown
- 1992-10-15 JP JP4319194A patent/JP2655790B2/ja not_active Expired - Fee Related
- 1992-10-22 TW TW081108424A patent/TW272233B/zh not_active IP Right Cessation
-
1994
- 1994-04-13 BG BG98714A patent/BG62261B1/bg unknown
- 1994-04-14 NO NO19941345A patent/NO315802B1/no unknown
- 1994-04-14 FI FI941730A patent/FI106965B/fi not_active IP Right Cessation
- 1994-05-27 US US08/250,310 patent/US5559005A/en not_active Expired - Fee Related
-
1995
- 1995-05-11 US US08/439,404 patent/US5629171A/en not_active Expired - Fee Related
-
1997
- 1997-04-17 US US08/839,327 patent/US6017726A/en not_active Expired - Fee Related
-
1999
- 1999-02-10 GR GR990400429T patent/GR3029343T3/el unknown
- 1999-06-28 US US09/340,781 patent/US6071713A/en not_active Expired - Fee Related
- 1999-12-27 IL IL13373399A patent/IL133733A0/xx unknown
- 1999-12-27 IL IL13373499A patent/IL133734A0/xx unknown
-
2002
- 2002-11-15 RU RU2002130702/13A patent/RU2002130702A/ru not_active Application Discontinuation
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