IL103419A - Bioprocess for preparing 7-aminodeacetyl-cephalosporanic acid and for preparing 7-aminocephalosporanic acid - Google Patents

Bioprocess for preparing 7-aminodeacetyl-cephalosporanic acid and for preparing 7-aminocephalosporanic acid

Info

Publication number
IL103419A
IL103419A IL10341992A IL10341992A IL103419A IL 103419 A IL103419 A IL 103419A IL 10341992 A IL10341992 A IL 10341992A IL 10341992 A IL10341992 A IL 10341992A IL 103419 A IL103419 A IL 103419A
Authority
IL
Israel
Prior art keywords
adipoyl
acid
side chain
preparing
aca
Prior art date
Application number
IL10341992A
Other languages
English (en)
Other versions
IL103419A0 (en
Original Assignee
Gist Brocades Bv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Gist Brocades Bv filed Critical Gist Brocades Bv
Publication of IL103419A0 publication Critical patent/IL103419A0/xx
Priority to IL13373399A priority Critical patent/IL133733A0/xx
Priority to IL13373499A priority patent/IL133734A0/xx
Publication of IL103419A publication Critical patent/IL103419A/xx

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
IL10341992A 1991-10-15 1992-10-14 Bioprocess for preparing 7-aminodeacetyl-cephalosporanic acid and for preparing 7-aminocephalosporanic acid IL103419A (en)

Priority Applications (2)

Application Number Priority Date Filing Date Title
IL13373399A IL133733A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca
IL13373499A IL133734A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06

Publications (2)

Publication Number Publication Date
IL103419A0 IL103419A0 (en) 1993-03-15
IL103419A true IL103419A (en) 2003-06-24

Family

ID=27119363

Family Applications (3)

Application Number Title Priority Date Filing Date
IL10341992A IL103419A (en) 1991-10-15 1992-10-14 Bioprocess for preparing 7-aminodeacetyl-cephalosporanic acid and for preparing 7-aminocephalosporanic acid
IL13373399A IL133733A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca
IL13373499A IL133734A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca

Family Applications After (2)

Application Number Title Priority Date Filing Date
IL13373399A IL133733A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca
IL13373499A IL133734A0 (en) 1991-10-15 1999-12-27 Bioprocess for preparing 7-aca

Country Status (27)

Country Link
US (4) US5559005A (xx)
EP (2) EP0856516B1 (xx)
JP (1) JP2655790B2 (xx)
KR (1) KR100227711B1 (xx)
CN (1) CN1074484A (xx)
AT (2) ATE174057T1 (xx)
AU (1) AU657800B2 (xx)
BG (1) BG62261B1 (xx)
CA (1) CA2080573C (xx)
CZ (1) CZ288721B6 (xx)
DE (2) DE69232581T2 (xx)
DK (2) DK0856516T3 (xx)
ES (2) ES2127205T3 (xx)
FI (1) FI106965B (xx)
GR (1) GR3029343T3 (xx)
HU (1) HU219370B (xx)
IL (3) IL103419A (xx)
MX (1) MX9205902A (xx)
NO (1) NO315802B1 (xx)
NZ (1) NZ244714A (xx)
RO (1) RO116648B1 (xx)
RU (1) RU2002130702A (xx)
SK (1) SK280569B6 (xx)
TW (1) TW272233B (xx)
UA (1) UA47385C2 (xx)
WO (1) WO1993008287A1 (xx)
YU (1) YU48930B (xx)

Families Citing this family (34)

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US6709859B1 (en) 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
BR9407104A (pt) * 1993-07-30 1996-08-27 Gist Brocades Nv Processo para a preparação e recuperação de ácido 7-amino desacetoxi cefalosporânico (7-adca) vetor de ADN recombinante e célula hospedeira transformada com um vetor definido
CN1103814C (zh) * 1993-07-30 2003-03-26 吉斯特·布罗卡迪斯公司 通过2－(羧乙硫基)乙酰－7－adca和3－(羧甲硫基)丙酰－7－adca有效生产7－adca的方法
US5882883A (en) * 1994-09-28 1999-03-16 Novo Nordisk A/S Process for the production of secondary metabolites
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
BR9608954A (pt) * 1995-06-02 1999-03-02 Gist Brocades Bv Processo para a produção de 7-adca via atividade de expandase na penicilina g
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
WO1997038107A1 (en) * 1996-04-04 1997-10-16 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
EP0914463A2 (en) 1996-07-16 1999-05-12 Gist-Brocades B.V. NOVEL PROCESS FOR THE PREPARATION OF CEPHALOSPORINS USING $i(ACREMONIUM CHRYSOGENUM)
DE69828940T2 (de) 1997-04-22 2005-12-29 Dsm Ip Assets B.V. Verbessertes verfahren zur fermentativen herstellung von cephalosporin
ZA983396B (en) * 1997-04-22 1998-10-27 Gist Brocades Bv A method for controlling the solubility of a beta-lactam nucleus
US6518039B2 (en) * 1997-04-22 2003-02-11 Dsm N.V. Process for the fermentative production of deacylated cephalosporins
DE69811039T2 (de) * 1997-04-22 2004-01-22 Dsm N.V. Verfahren für die fermentative produktion von deazylierten cephalosporinen.
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
ES2186347T3 (es) 1998-03-27 2003-05-01 Dsm Nv Nuevo procedimiento de produccion por fermentacion de cefalosporina.
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
CN1331751A (zh) * 1998-12-22 2002-01-16 Dsm公司 改进的头孢菌素的体内生产方法
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
CN1222528C (zh) 2000-05-13 2005-10-12 史密斯克莱·比奇曼公司 提纯克拉布兰酸盐的方法
US6699699B2 (en) * 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
KR20060061295A (ko) * 2003-05-28 2006-06-07 디에스엠 아이피 어셋츠 비.브이. 세펨 화합물
CN101389635B (zh) * 2006-02-23 2013-03-06 中化帝斯曼制药有限公司荷兰公司 改进的头孢菌素生产
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
WO2010115838A1 (en) 2009-04-03 2010-10-14 Dsm Ip Assets B.V. Fermentation process
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
CN103003439A (zh) 2010-06-22 2013-03-27 中化帝斯曼制药有限公司荷兰公司 气泡发酵工艺
EP2614066B1 (en) 2010-09-07 2017-11-29 DSM Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101808192B1 (ko) * 2016-08-26 2018-01-18 아미코젠주식회사 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

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US5070020A (en) * 1988-05-09 1991-12-03 Eli Lilly And Company Recombinant dna expression vectors and dna compounds that encode deacetoxycephalosporin c synthetase
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JP2928884B2 (ja) * 1989-02-01 1999-08-03 武田薬品工業株式会社 Ｄｎａおよびその用途
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JPH03254684A (ja) * 1990-03-02 1991-11-13 Asahi Chem Ind Co Ltd 新規ｃＤＮＡ化合物
CA2045951A1 (en) * 1990-07-06 1992-01-07 Steven Kovacevic Recombinant dna expression vectors and dna compounds that encode deacetylcephalosporin c synthase activity
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)

Also Published As

Publication number Publication date
IL103419A0 (en) 1993-03-15
EP0856516A1 (en) 1998-08-05
ES2127205T3 (es) 1999-04-16
DE69227750D1 (de) 1999-01-14
EP0540210A1 (en) 1993-05-05
UA47385C2 (uk) 2002-07-15
DE69227750T2 (de) 1999-04-22
DK0856516T3 (da) 2002-07-29
TW272233B (xx) 1996-03-11
EP0540210B1 (en) 1998-12-02
WO1993008287A1 (en) 1993-04-29
US6071713A (en) 2000-06-06
HU219370B (en) 2001-03-28
BG62261B1 (bg) 1999-06-30
DE69232581T2 (de) 2002-11-14
ATE216700T1 (de) 2002-05-15
CZ88494A3 (en) 1995-03-15
EP0856516B1 (en) 2002-04-24
FI106965B (fi) 2001-05-15
US5629171A (en) 1997-05-13
DK0540210T3 (da) 1999-06-23
ES2176613T3 (es) 2002-12-01
RU2002130702A (ru) 2004-05-20
RO116648B1 (ro) 2001-04-30
GR3029343T3 (en) 1999-05-28
US5559005A (en) 1996-09-24
AU2701692A (en) 1993-04-22
IL133734A0 (en) 2001-04-30
MX9205902A (es) 1994-06-30
NZ244714A (en) 1994-03-25
CA2080573A1 (en) 1993-04-16
CN1074484A (zh) 1993-07-21
HU9401073D0 (en) 1994-07-28
YU92592A (sh) 1995-10-03
SK43194A3 (en) 1996-11-06
IL133733A0 (en) 2001-04-30
CZ288721B6 (cs) 2001-08-15
AU657800B2 (en) 1995-03-23
JP2655790B2 (ja) 1997-09-24
NO941345D0 (no) 1994-04-14
BG98714A (bg) 1995-02-28
ATE174057T1 (de) 1998-12-15
JPH06113884A (ja) 1994-04-26
SK280569B6 (sk) 2000-03-13
CA2080573C (en) 2004-01-06
FI941730A (fi) 1994-04-14
NO941345L (no) 1994-06-15
FI941730A0 (fi) 1994-04-14
US6017726A (en) 2000-01-25
HUT69783A (en) 1995-09-28
KR100227711B1 (ko) 1999-12-01
NO315802B1 (no) 2003-10-27
DE69232581D1 (de) 2002-05-29
YU48930B (sh) 2002-12-10

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