DK0856516T3 - Adipoyl-7-aminodeacetylcephalosporansyre - Google Patents

Adipoyl-7-aminodeacetylcephalosporansyre

Info

Publication number
DK0856516T3
DK0856516T3 DK97204046T DK97204046T DK0856516T3 DK 0856516 T3 DK0856516 T3 DK 0856516T3 DK 97204046 T DK97204046 T DK 97204046T DK 97204046 T DK97204046 T DK 97204046T DK 0856516 T3 DK0856516 T3 DK 0856516T3
Authority
DK
Denmark
Prior art keywords
adipoyl
side chain
acid
aca
whose expression
Prior art date
Application number
DK97204046T
Other languages
Danish (da)
English (en)
Inventor
Michael J Conder
Anthony Michael Stepan
Lorilee Crawford
John A Rambosek
Phyllis C Mcada
Christopher D Reeves
Original Assignee
Dsm Nv
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Dsm Nv filed Critical Dsm Nv
Application granted granted Critical
Publication of DK0856516T3 publication Critical patent/DK0856516T3/da

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/0004—Oxidoreductases (1.)
    • C12N9/0071—Oxidoreductases (1.) acting on paired donors with incorporation of molecular oxygen (1.14)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/10—Transferases (2.)
    • C12N9/1025—Acyltransferases (2.3)
    • C12N9/1029—Acyltransferases (2.3) transferring groups other than amino-acyl groups (2.3.1)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P35/00—Preparation of compounds having a 5-thia-1-azabicyclo [4.2.0] octane ring system, e.g. cephalosporin
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
    • C12P37/04—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin by acylation of the substituent in the 6 position
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10—TECHNICAL SUBJECTS COVERED BY FORMER USPC
    • Y10S—TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y10S435/00—Chemistry: molecular biology and microbiology
    • Y10S435/8215—Microorganisms
    • Y10S435/911—Microorganisms using fungi
    • Y10S435/933—Penicillium
    • Y10S435/935—Penicillium chrysogenum

Landscapes

  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Engineering & Computer Science (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Microbiology (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Cephalosporin Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Medicinal Preparation (AREA)
DK97204046T 1991-10-15 1992-10-14 Adipoyl-7-aminodeacetylcephalosporansyre DK0856516T3 (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US77783391A 1991-10-15 1991-10-15
US95349292A 1992-10-06 1992-10-06

Publications (1)

Publication Number Publication Date
DK0856516T3 true DK0856516T3 (da) 2002-07-29

Family

ID=27119363

Family Applications (2)

Application Number Title Priority Date Filing Date
DK92309351T DK0540210T3 (da) 1991-10-15 1992-10-14 Ny biologisk fremgangsmåde til fremstilling af 7-ACA og 7-ADAC
DK97204046T DK0856516T3 (da) 1991-10-15 1992-10-14 Adipoyl-7-aminodeacetylcephalosporansyre

Family Applications Before (1)

Application Number Title Priority Date Filing Date
DK92309351T DK0540210T3 (da) 1991-10-15 1992-10-14 Ny biologisk fremgangsmåde til fremstilling af 7-ACA og 7-ADAC

Country Status (27)

Country Link
US (4) US5559005A (xx)
EP (2) EP0540210B1 (xx)
JP (1) JP2655790B2 (xx)
KR (1) KR100227711B1 (xx)
CN (1) CN1074484A (xx)
AT (2) ATE174057T1 (xx)
AU (1) AU657800B2 (xx)
BG (1) BG62261B1 (xx)
CA (1) CA2080573C (xx)
CZ (1) CZ288721B6 (xx)
DE (2) DE69232581T2 (xx)
DK (2) DK0540210T3 (xx)
ES (2) ES2127205T3 (xx)
FI (1) FI106965B (xx)
GR (1) GR3029343T3 (xx)
HU (1) HU219370B (xx)
IL (3) IL103419A (xx)
MX (1) MX9205902A (xx)
NO (1) NO315802B1 (xx)
NZ (1) NZ244714A (xx)
RO (1) RO116648B1 (xx)
RU (1) RU2002130702A (xx)
SK (1) SK280569B6 (xx)
TW (1) TW272233B (xx)
UA (1) UA47385C2 (xx)
WO (1) WO1993008287A1 (xx)
YU (1) YU48930B (xx)

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EP0233715B1 (en) * 1986-01-31 1994-05-25 BEECHAM GROUP plc Isolation and expression of genes involved in the biosynthesis of beta-lactams
US6709859B1 (en) * 1986-01-31 2004-03-23 Beecham Group P.L.C. Chromosomal DNA Fragments Encoding Enzymes for Encoding B-Lactam Biosynthesis Enzymes, and Vector and Transformants for Their Expression
KR0171897B1 (ko) * 1989-12-27 1999-02-01 후지사와 도모끼찌로 7-아미노세펨 화합물 또는 그 염류의 제조 방법
US5318896A (en) * 1991-09-11 1994-06-07 Merck & Co., Inc. Recombinant expandase bioprocess for preparing 7-aminodesacetoxy cephalosporanic acid (7-ADCA)
HU219259B (en) * 1993-07-30 2001-03-28 Gist Brocades Bv Process for the efficient production of 7-adca via 2-(carboxyethylthio)acetyl-7-adca and 3-(carboxymethylthio)propionyl-7-adca, recombinant dna vectrors and transformed host cells
CZ285622B6 (cs) * 1993-07-30 1999-10-13 Gist-Brocades B. V. Způsob výroby a izolace 7-aminodesacetoxycafalosporanové kyseliny, rekombinantní DNA vektor a hostitelská buňka
JP3764166B2 (ja) * 1994-09-28 2006-04-05 ノボザイムス アクティーゼルスカブ 二次代謝産物を産生するための方法
DE4437420A1 (de) * 1994-10-19 1996-04-25 Hoechst Ag Verbessertes, induktionsfreies Verfahren zur gentechnischen Herstellung von Glutarylamidase
US5731165A (en) * 1995-06-02 1998-03-24 Gist-Brocades, B.V. Process for the production of 7-ADCA via expandase activity on penicillin G
CA2223105A1 (en) * 1995-06-02 1996-12-05 Gist-Brocades B.V. Process for the production of 7-adca via expandase activity on penicillin g
AU2508897A (en) * 1996-04-04 1997-10-29 Gist-Brocades B.V. An enzyme with high adipoyl-coenzyme a synthetase activity and uses thereof
AU4201897A (en) 1996-07-16 1998-02-09 Gist-Brocades B.V. Novel process for the preparation of cephalosporins using (acremonium chrysogenum)
ZA983394B (en) * 1997-04-22 1998-10-30 Gist Brocades Bv Process for the fermentative production of deacylated cephalosporins
EP0915988B1 (en) * 1997-04-22 2003-01-29 Dsm N.V. Process for the fermentative production of deacylated cephalosporins
JP2000512510A (ja) * 1997-04-22 2000-09-26 ギスト ブロカデス ベスローテン フェンノートシャップ セファロスポリンの発酵生産の改良法
AU7648798A (en) * 1997-04-22 1998-11-13 Gist-Brocades B.V. A method for controlling the solubility of a beta-lactam nucleus
WO1999010499A1 (en) * 1997-08-22 1999-03-04 Dsm N.V. Statin production by fermentation
EP1066294B1 (en) 1998-03-27 2002-10-30 Dsm N.V. Novel process for the fermentative production of cephalosporin
US6383773B2 (en) 1998-04-23 2002-05-07 Massachusetts Institute Of Technology Penicillin conversion
AU3042600A (en) * 1998-12-22 2000-07-12 Dsm N.V. Improved (in vivo) production of cephalosporins
ES2165276B1 (es) * 1999-06-18 2003-03-01 Antibioticos Sau Procedimiento biotecnologico para la produccion de acido 7-aminocefal osporanico (7-adca) y compuestos de sintesis intermedios particularmente penicilina n y desacetoxicefalosporina c (daoc)
EP1284978B2 (en) 2000-05-13 2008-09-10 Smithkline Beecham Plc Process for the purification of a salt of clavulanic acid
US6699699B2 (en) 2002-03-26 2004-03-02 Synmax Biochemical Co., Ltd. Mutated penicillin expandases
CN1795197B (zh) * 2003-05-28 2010-06-02 帝斯曼知识产权资产管理有限公司 头孢菌素类化合物
BRPI0708232A2 (pt) * 2006-02-23 2011-05-17 Dsm Ip Assets Bv microorganismo que produz cefalosporina, método para a construção de um microorganismo e processo para a produção de uma cefalosporina
KR101569832B1 (ko) * 2008-11-19 2015-11-18 삼성전자주식회사 시료 중의 게놈 ｄｎａ 및 플라스미드 ｄｎａ를 서로 분리하는 방법 및 그를 위한 키트
CN101429538B (zh) * 2008-12-12 2011-05-25 河北九派制药有限公司 7-α-甲氧基-3-去乙酰基头孢噻吩苄星盐的制备方法
CN102369290A (zh) 2009-04-03 2012-03-07 帝斯曼知识产权资产管理有限公司 发酵工艺
US8863444B2 (en) 2010-05-31 2014-10-21 Feature Walters Assembly system for modular building units
CN103003439A (zh) 2010-06-22 2013-03-27 中化帝斯曼制药有限公司荷兰公司 气泡发酵工艺
WO2012032040A1 (en) 2010-09-07 2012-03-15 Dsm Sinochem Pharmaceuticals Netherlands B.V. Process for the production of cephalosporins
CN102702229A (zh) * 2011-08-04 2012-10-03 重庆天地药业有限责任公司 一种头孢唑肟钠关键中间体的制备及高含量头孢唑肟钠的制备
WO2015091455A1 (en) 2013-12-17 2015-06-25 Dpx Holdings B.V. Bioreactor
KR101808192B1 (ko) * 2016-08-26 2018-01-18 아미코젠주식회사 7-아미노세팔로스포란산의 고농도 생산 재조합 아크레모니움 크리소제눔 균주의 제조방법 및 이 방법으로 제조된 균주

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Also Published As

Publication number Publication date
BG98714A (bg) 1995-02-28
GR3029343T3 (en) 1999-05-28
FI941730A0 (fi) 1994-04-14
JPH06113884A (ja) 1994-04-26
RU2002130702A (ru) 2004-05-20
RO116648B1 (ro) 2001-04-30
CZ288721B6 (cs) 2001-08-15
FI941730A (fi) 1994-04-14
JP2655790B2 (ja) 1997-09-24
SK280569B6 (sk) 2000-03-13
ATE174057T1 (de) 1998-12-15
US5629171A (en) 1997-05-13
YU92592A (sh) 1995-10-03
YU48930B (sh) 2002-12-10
AU657800B2 (en) 1995-03-23
WO1993008287A1 (en) 1993-04-29
HU9401073D0 (en) 1994-07-28
NO941345L (no) 1994-06-15
ES2127205T3 (es) 1999-04-16
ATE216700T1 (de) 2002-05-15
IL103419A0 (en) 1993-03-15
NZ244714A (en) 1994-03-25
EP0856516A1 (en) 1998-08-05
NO941345D0 (no) 1994-04-14
IL133734A0 (en) 2001-04-30
MX9205902A (es) 1994-06-30
HU219370B (en) 2001-03-28
SK43194A3 (en) 1996-11-06
US6071713A (en) 2000-06-06
CA2080573C (en) 2004-01-06
DK0540210T3 (da) 1999-06-23
UA47385C2 (uk) 2002-07-15
NO315802B1 (no) 2003-10-27
IL103419A (en) 2003-06-24
CN1074484A (zh) 1993-07-21
TW272233B (xx) 1996-03-11
EP0856516B1 (en) 2002-04-24
FI106965B (fi) 2001-05-15
ES2176613T3 (es) 2002-12-01
CA2080573A1 (en) 1993-04-16
IL133733A0 (en) 2001-04-30
AU2701692A (en) 1993-04-22
CZ88494A3 (en) 1995-03-15
DE69227750T2 (de) 1999-04-22
DE69227750D1 (de) 1999-01-14
EP0540210A1 (en) 1993-05-05
EP0540210B1 (en) 1998-12-02
US5559005A (en) 1996-09-24
US6017726A (en) 2000-01-25
DE69232581D1 (de) 2002-05-29
KR100227711B1 (ko) 1999-12-01
BG62261B1 (bg) 1999-06-30
HUT69783A (en) 1995-09-28
DE69232581T2 (de) 2002-11-14

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