ATE334203T1 - Verfahren zur herstellung von sekundären metaboliten - Google Patents
Verfahren zur herstellung von sekundären metabolitenInfo
- Publication number
- ATE334203T1 ATE334203T1 AT95931924T AT95931924T ATE334203T1 AT E334203 T1 ATE334203 T1 AT E334203T1 AT 95931924 T AT95931924 T AT 95931924T AT 95931924 T AT95931924 T AT 95931924T AT E334203 T1 ATE334203 T1 AT E334203T1
- Authority
- AT
- Austria
- Prior art keywords
- microorganism
- secondary metabolite
- pct
- metabolite
- producing
- Prior art date
Links
- 229930000044 secondary metabolite Natural products 0.000 title abstract 6
- 238000004519 manufacturing process Methods 0.000 title abstract 3
- 244000005700 microbiome Species 0.000 abstract 5
- 108091028043 Nucleic acid sequence Proteins 0.000 abstract 2
- 238000000034 method Methods 0.000 abstract 2
- 108020004414 DNA Proteins 0.000 abstract 1
- 102000004190 Enzymes Human genes 0.000 abstract 1
- 108090000790 Enzymes Proteins 0.000 abstract 1
- 230000006696 biosynthetic metabolic pathway Effects 0.000 abstract 1
- 238000000855 fermentation Methods 0.000 abstract 1
- 230000004151 fermentation Effects 0.000 abstract 1
- 230000002452 interceptive effect Effects 0.000 abstract 1
- 239000002207 metabolite Substances 0.000 abstract 1
- 108090000765 processed proteins & peptides Proteins 0.000 abstract 1
- 108090000623 proteins and genes Proteins 0.000 abstract 1
- 102000004169 proteins and genes Human genes 0.000 abstract 1
- 230000001105 regulatory effect Effects 0.000 abstract 1
- 230000009466 transformation Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/93—Ligases (6)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
- C12N15/52—Genes encoding for enzymes or proenzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P1/00—Preparation of compounds or compositions, not provided for in groups C12P3/00 - C12P39/00, by using microorganisms or enzymes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
- C12P37/00—Preparation of compounds having a 4-thia-1-azabicyclo [3.2.0] heptane ring system, e.g. penicillin
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biomedical Technology (AREA)
- Biochemistry (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Mycology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Steroid Compounds (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| DK111894 | 1994-09-28 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE334203T1 true ATE334203T1 (de) | 2006-08-15 |
Family
ID=8101219
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT95931924T ATE334203T1 (de) | 1994-09-28 | 1995-09-28 | Verfahren zur herstellung von sekundären metaboliten |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US5882883A (de) |
| EP (1) | EP0783581B1 (de) |
| JP (1) | JP3764166B2 (de) |
| AT (1) | ATE334203T1 (de) |
| AU (1) | AU3517895A (de) |
| DE (1) | DE69535126D1 (de) |
| WO (1) | WO1996010084A1 (de) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6524812B1 (en) | 1993-10-07 | 2003-02-25 | Regents Of The University Of Minnesota | Genes encoding resistance to DNA alkylating agents |
| US6495348B1 (en) | 1993-10-07 | 2002-12-17 | Regents Of The University Of Minnesota | Mitomycin biosynthetic gene cluster |
| WO1997022711A1 (en) | 1995-12-19 | 1997-06-26 | Regents Of The University Of Minnesota | Metabolic engineering of polyhydroxyalkanoate monomer synthases |
| US7390619B1 (en) * | 1998-02-11 | 2008-06-24 | Maxygen, Inc. | Optimization of immunomodulatory properties of genetic vaccines |
| US6541011B2 (en) | 1998-02-11 | 2003-04-01 | Maxygen, Inc. | Antigen library immunization |
| US6451564B1 (en) * | 1999-07-02 | 2002-09-17 | Massachusetts Institute Of Technology | Methods for producing L-isoleucine |
| US6284483B1 (en) * | 1999-10-06 | 2001-09-04 | Board Of Trustees Operating Michigan State University | Modified synthetases to produce penicillins and cephalosporins under the control of bicarbonate |
| JP7755921B2 (ja) | 2019-03-29 | 2025-10-17 | 味の素株式会社 | 制御装置、制御方法およびプログラムならびに有機化合物の製造方法 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE3683080D1 (de) * | 1985-04-22 | 1992-02-06 | Lilly Co Eli | Rekombinante dns-expressionsvektoren und dns-verbindungen. |
| RU1780542C (ru) * | 1985-04-22 | 1992-12-07 | Эли Лилли Энд Компани | Способ конструировани рекомбинантной плазмидной ДНК pPS 20, кодирующей изопенициллин-N-синтетазу, способ получени штамма СернаLоSроRIUм асRемоNIUм, обладающего активностью изопенициллин-N-синтетазы |
| US4892819A (en) * | 1985-11-25 | 1990-01-09 | Eli Lilly And Company | Recombinant DNA expression vectors and DNA compounds that encode isopenicillin N synthetase from penicillium chrysogenum |
| ATE100147T1 (de) * | 1986-09-16 | 1994-01-15 | Gist Brocades Nv | Penicilliumtransformanten und verfahren zu ihrer herstellung. |
| US5108918A (en) * | 1988-08-11 | 1992-04-28 | Gist-Brocades | Method for identifying and using biosynthetic genes for enhanced production of secondary metabolites |
| FI104984B (fi) * | 1988-08-11 | 2000-05-15 | Dsm Nv | Menetelmä biosynteettisten tai säätelygeenien identifioimiseksi ja käyttämiseksi sekundääristen metaboliittien tuoton parantamiseksi |
| FI104264B (fi) * | 1988-08-11 | 1999-12-15 | Dsm Ip Assets Bv | Menetelmä sekundääristen metaboliittien tuoton parantamiseksi käyttämällä rykelmöityjä biosynteettisiä geenejä |
| EP0377295B1 (de) * | 1988-12-22 | 1995-02-01 | Eli Lilly And Company | Rekombinante DNA enthaltende Expressionsvektoren und für Isopenicillin-N-Epimerase-(Racemase)-Aktivität kodierende DNS-Verbindungen |
| FR2642768B1 (fr) * | 1989-01-19 | 1991-05-17 | Transgene Sa | Procede perfectionne pour l'expression de la biotine dans bacillus sphaericus |
| IL95766A (en) * | 1989-09-27 | 1996-12-05 | Lilly Co Eli | Recombinant DNA expression vectors And DNA compounds. Which encode Aspergillus acyltransferase activity |
| IE910956A1 (en) * | 1990-03-23 | 1991-09-25 | Gist Brocades Nv | A method of modulating the production of secondary¹metabolites |
| SK280569B6 (sk) * | 1991-10-15 | 2000-03-13 | Gist-Brocades B.V. | Biologický spôsob výroby kyseliny7-aminodeacetylce |
| KR100336174B1 (ko) * | 1993-07-30 | 2002-11-01 | 디에스엠 기스트 베.파우. | 2-(카르복시에틸티오)아세틸-7-adca및3-(카르복시메틸티오)프로피오닐-7-adca를경유하여7-adca를제조하는효율적인방법 |
| US5474912A (en) * | 1994-03-03 | 1995-12-12 | Sherman; David H. | Method for increasing production of microbial metabolites by genetic engineering |
-
1995
- 1995-09-28 WO PCT/DK1995/000386 patent/WO1996010084A1/en not_active Ceased
- 1995-09-28 JP JP51129196A patent/JP3764166B2/ja not_active Expired - Fee Related
- 1995-09-28 AT AT95931924T patent/ATE334203T1/de not_active IP Right Cessation
- 1995-09-28 AU AU35178/95A patent/AU3517895A/en not_active Abandoned
- 1995-09-28 EP EP95931924A patent/EP0783581B1/de not_active Expired - Lifetime
- 1995-09-28 DE DE69535126T patent/DE69535126D1/de not_active Expired - Lifetime
- 1995-09-28 US US08/793,786 patent/US5882883A/en not_active Expired - Fee Related
Also Published As
| Publication number | Publication date |
|---|---|
| US5882883A (en) | 1999-03-16 |
| JP3764166B2 (ja) | 2006-04-05 |
| EP0783581B1 (de) | 2006-07-26 |
| JPH10506283A (ja) | 1998-06-23 |
| WO1996010084A1 (en) | 1996-04-04 |
| DE69535126D1 (de) | 2006-09-07 |
| AU3517895A (en) | 1996-04-19 |
| EP0783581A1 (de) | 1997-07-16 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |