ES2733051T1 - Matriz para liberación sostenida, invariable e independiente de compuestos activos - Google Patents

Matriz para liberación sostenida, invariable e independiente de compuestos activos Download PDF

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Publication number
ES2733051T1
ES2733051T1 ES17154462T ES17154462T ES2733051T1 ES 2733051 T1 ES2733051 T1 ES 2733051T1 ES 17154462 T ES17154462 T ES 17154462T ES 17154462 T ES17154462 T ES 17154462T ES 2733051 T1 ES2733051 T1 ES 2733051T1
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ES
Spain
Prior art keywords
pharmaceutically acceptable
acceptable salt
pharmaceutical formulation
naloxone
formulation according
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
ES17154462T
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English (en)
Inventor
Bianca BRÖGMANN
Silke MÜHLAU
Christof Spitzley
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Euro Celtique SA
Original Assignee
Euro Celtique SA
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=28676052&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=ES2733051(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from DE10215131A external-priority patent/DE10215131A1/de
Priority claimed from DE10215067A external-priority patent/DE10215067A1/de
Application filed by Euro Celtique SA filed Critical Euro Celtique SA
Publication of ES2733051T1 publication Critical patent/ES2733051T1/es
Pending legal-status Critical Current

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/485—Morphinan derivatives, e.g. morphine, codeine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0053—Mouth and digestive tract, i.e. intraoral and peroral administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1617—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/14—Particulate form, e.g. powders, Processes for size reducing of pure drugs or the resulting products, Pure drug nanoparticles
    • A61K9/16—Agglomerates; Granulates; Microbeadlets ; Microspheres; Pellets; Solid products obtained by spray drying, spray freeze drying, spray congealing,(multiple) emulsion solvent evaporation or extraction
    • A61K9/1605—Excipients; Inactive ingredients
    • A61K9/1629—Organic macromolecular compounds
    • A61K9/1652—Polysaccharides, e.g. alginate, cellulose derivatives; Cyclodextrin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2009—Inorganic compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2013—Organic compounds, e.g. phospholipids, fats
    • A61K9/2018—Sugars, or sugar alcohols, e.g. lactose, mannitol; Derivatives thereof, e.g. polysorbates
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2004—Excipients; Inactive ingredients
    • A61K9/2022—Organic macromolecular compounds
    • A61K9/205—Polysaccharides, e.g. alginate, gums; Cyclodextrin
    • A61K9/2054—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2072—Pills, tablets, discs, rods characterised by shape, structure or size; Tablets with holes, special break lines or identification marks; Partially coated tablets; Disintegrating flat shaped forms
    • A61K9/2077—Tablets comprising drug-containing microparticles in a substantial amount of supporting matrix; Multiparticulate tablets
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/2095—Tabletting processes; Dosage units made by direct compression of powders or specially processed granules, by eliminating solvents, by melt-extrusion, by injection molding, by 3D printing
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/286—Polysaccharides, e.g. gums; Cyclodextrin
    • A61K9/2866—Cellulose; Cellulose derivatives, e.g. hydroxypropyl methylcellulose
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/70—Web, sheet or filament bases ; Films; Fibres of the matrix type containing drug
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/10—Laxatives
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P13/00—Drugs for disorders of the urinary system
    • A61P13/12—Drugs for disorders of the urinary system of the kidneys
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P17/00—Drugs for dermatological disorders
    • A61P17/04—Antipruritics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/04—Centrally acting analgesics, e.g. opioids
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
    • A61P25/36—Opioid-abuse
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Emergency Medicine (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Neurology (AREA)
  • Addiction (AREA)
  • Pain & Pain Management (AREA)
  • Nutrition Science (AREA)
  • Inorganic Chemistry (AREA)
  • Physiology (AREA)
  • Dermatology (AREA)
  • Urology & Nephrology (AREA)
  • Rheumatology (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Medical Treatment And Welfare Office Work (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)

Abstract

Una formulación farmacéutica que comprende una matriz, en la que dicha matriz comprende oxicodona o una sal farmacéuticamente aceptable de la misma, naloxona o una sal farmacéuticamente aceptable de la misma, y etilcelulosa o un alcohol graso.

Claims (15)

REIVINDICACIONES
1. Una formulación farmacéutica que comprende una matriz, en la que dicha matriz comprende oxicodona o una sal farmacéuticamente aceptable de la misma, naloxona o una sal farmacéuticamente aceptable de la misma, y etilcelulosa o un alcohol graso.
2. La formulación farmacéutica según la reivindicación 1, en la que la etilcelulosa o el alcohol graso está comprendido en la formulación como retardante.
3. La formulación farmacéutica según la reivindicación 1 o 2, en la que dicha matriz comprende oxicodona o una sal farmacéuticamente aceptable de la misma, naloxona o una sal farmacéuticamente aceptable de la misma, etilcelulosa, lactosa, talco y estearato de magnesio.
4. La formulación farmacéutica según la reivindicación 1 o 2, en la que dicha matriz comprende oxicodona o una sal farmacéuticamente aceptable de la misma, naloxona o una sal farmacéuticamente aceptable de la misma, un alcohol graso, celulosa microcristalina, povidona, talco y estearato de magnesio, en el que dicho alcohol graso es preferiblemente alcohol estearilo.
5. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación es una formulación oral.
6. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación es una tableta, tableta multicapa, cápsula o gránulo.
7. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación comprende oxicodona o una sal farmacéuticamente aceptable de la misma en una relación en peso de 15:1, 10:1, 5:1, 4:1, 3:1, 2:1 o 1:1 a naloxona o una sal farmacéuticamente aceptable de la misma.
8. La formulación farmacéutica según una cualquiera de las reivindicaciones 1 a 6, en la que la formulación comprende oxicodona o una sal farmacéuticamente aceptable de la misma en una relación en peso de 2:1 a naloxona o una sal farmacéuticamente aceptable de la misma.
9. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación comprende oxicodona o una sal farmacéuticamente aceptable de la misma en una cantidad de 10 mg y 150 mg.
10. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación comprende naloxona o una sal farmacéuticamente aceptable de la misma en una cantidad de 1 a 50 mg.
11. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación libera 1% a 40% de oxicodona o una sal farmacéuticamente aceptable de la misma y naloxona o una sal farmacéuticamente aceptable de la misma después de 15 minutos, 40% a 85% de oxicodona o un sal farmacéuticamente aceptable de la misma y naloxona o una sal farmacéuticamente aceptable de la misma después de 2 horas, 65% a 100% de oxicodona o una sal farmacéuticamente aceptable de la misma y naloxona o una sal farmacéuticamente aceptable de la misma después de 7 horas y 85% a 100% de oxicodona o un sal farmacéuticamente aceptable de los mismos y naloxona o una sal farmacéuticamente aceptable de los mismos después de 12 horas, según lo determinado por el método de análisis ABC (Basket Method) según USP a pH 1,2 con HPLC.
12. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación comprende oxicodona y naloxona como el hidrocloruro, sulfato, bisulfato, tartrato, nitrato, citrato, bitratrato, fosfato, malato, maleato, bromhidrato, yoduro, fumarato o succinato.
13. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación es estable al almacenamiento.
14. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la matriz es una matriz de difusión.
15. La formulación farmacéutica según una cualquiera de las reivindicaciones anteriores, en la que la formulación es para uso en el tratamiento del dolor y para uso en el tratamiento simultáneo del estreñimiento inducido por opioides.
ES17154462T 2002-04-05 2003-04-04 Matriz para liberación sostenida, invariable e independiente de compuestos activos Pending ES2733051T1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DE10215131A DE10215131A1 (de) 2002-04-05 2002-04-05 Matrix zur verzögerten, gleichbleibenden und unabhängigen Freisetzung von Wirkstoffen
DE10215067A DE10215067A1 (de) 2002-04-05 2002-04-05 Lagerstabiles pharmazeutisches Präparat, das Oxycodon und Naloxon umfasst

Publications (1)

Publication Number Publication Date
ES2733051T1 true ES2733051T1 (es) 2019-11-27

Family

ID=28676052

Family Applications (7)

Application Number Title Priority Date Filing Date
ES17169621T Pending ES2733044T1 (es) 2002-04-05 2003-04-04 Composición farmacéutica que contiene oxicodona y naloxona
ES11177516.9T Expired - Lifetime ES2627298T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES11177520.1T Expired - Lifetime ES2608006T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES11177518.5T Expired - Lifetime ES2627300T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES03720424.5T Expired - Lifetime ES2546010T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES03720425.2T Expired - Lifetime ES2320748T5 (es) 2002-04-05 2003-04-04 Matriz para la liberación sostenida, invariable e independiente de compuestos activos
ES17154462T Pending ES2733051T1 (es) 2002-04-05 2003-04-04 Matriz para liberación sostenida, invariable e independiente de compuestos activos

Family Applications Before (6)

Application Number Title Priority Date Filing Date
ES17169621T Pending ES2733044T1 (es) 2002-04-05 2003-04-04 Composición farmacéutica que contiene oxicodona y naloxona
ES11177516.9T Expired - Lifetime ES2627298T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES11177520.1T Expired - Lifetime ES2608006T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES11177518.5T Expired - Lifetime ES2627300T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES03720424.5T Expired - Lifetime ES2546010T3 (es) 2002-04-05 2003-04-04 Preparación farmacéutica que contiene oxicodona y naloxona
ES03720425.2T Expired - Lifetime ES2320748T5 (es) 2002-04-05 2003-04-04 Matriz para la liberación sostenida, invariable e independiente de compuestos activos

Country Status (33)

Country Link
US (11) US20050245483A1 (es)
EP (17) EP2316429A1 (es)
JP (5) JP4620355B2 (es)
KR (3) KR20040098050A (es)
CN (4) CN1646102B (es)
AP (2) AP2043A (es)
AR (3) AR039379A1 (es)
AT (1) ATE418967T2 (es)
AU (2) AU2003224041B2 (es)
BR (2) BR0309004A (es)
CA (3) CA2478515C (es)
CO (2) CO5611100A2 (es)
CY (5) CY1108914T1 (es)
DE (6) DE20321531U1 (es)
DK (6) DK2425824T5 (es)
ES (7) ES2733044T1 (es)
FI (1) FI7846U1 (es)
GE (3) GEP20074022B (es)
HK (5) HK1072366A1 (es)
HU (4) HUE027004T2 (es)
IL (5) IL163990A0 (es)
LT (3) LT2425821T (es)
MA (2) MA27116A1 (es)
MX (2) MXPA04009713A (es)
NZ (1) NZ535286A (es)
PH (1) PH12018000176A1 (es)
PT (5) PT2425824T (es)
RU (3) RU2295344C2 (es)
SI (5) SI2425824T1 (es)
TN (1) TNSN04192A1 (es)
TW (3) TWI337077B (es)
WO (2) WO2003084520A2 (es)
ZA (2) ZA200407267B (es)

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* Cited by examiner, † Cited by third party
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RS50070B (sr) 1997-12-22 2009-01-22 Euro-Celtique S.A., Oralni dozni oblik sa kombinacijom opijatnog agonista i antagonista
US6375957B1 (en) 1997-12-22 2002-04-23 Euro-Celtique, S.A. Opioid agonist/opioid antagonist/acetaminophen combinations
ATE526950T1 (de) 1999-10-29 2011-10-15 Euro Celtique Sa Hydrocodon-formulierungen mit gesteuerter freisetzung
US10179130B2 (en) 1999-10-29 2019-01-15 Purdue Pharma L.P. Controlled release hydrocodone formulations
EP2517710B1 (en) 2000-02-08 2015-03-25 Euro-Celtique S.A. Tamper-resistant oral opioid agonist formulations
AUPQ899700A0 (en) 2000-07-25 2000-08-17 Borody, Thomas Julius Probiotic recolonisation therapy
EP2263658A1 (en) 2000-10-30 2010-12-22 Euro-Celtique S.A. Controlled release hydrocodone formulations
US20110104214A1 (en) 2004-04-15 2011-05-05 Purdue Pharma L.P. Once-a-day oxycodone formulations
CN1525851A (zh) 2001-05-11 2004-09-01 ������ҩ�����޹�˾ 抗滥用阿片样物质控释剂型
ATE419039T1 (de) 2001-07-18 2009-01-15 Euro Celtique Sa Pharmazeutische kombinationen von oxycodon und naloxon
DE60232417D1 (de) 2001-08-06 2009-07-02 Euro Celtique Sa Opioid-agonist-formulierungen mit freisetzbarem und sequestriertem antagonist
DK2425824T5 (en) 2002-04-05 2018-02-12 Mundipharma As Pharmaceutical preparation containing oxycodone and naloxone
US7776314B2 (en) 2002-06-17 2010-08-17 Grunenthal Gmbh Abuse-proofed dosage system
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