ATE326222T1 - Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch - Google Patents
Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauchInfo
- Publication number
- ATE326222T1 ATE326222T1 AT01920377T AT01920377T ATE326222T1 AT E326222 T1 ATE326222 T1 AT E326222T1 AT 01920377 T AT01920377 T AT 01920377T AT 01920377 T AT01920377 T AT 01920377T AT E326222 T1 ATE326222 T1 AT E326222T1
- Authority
- AT
- Austria
- Prior art keywords
- naltrexone
- naloxone
- treatment
- analogs
- pain
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 8
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title abstract 6
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical class N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title abstract 6
- 229960004127 naloxone Drugs 0.000 title abstract 4
- 206010013654 Drug abuse Diseases 0.000 title 1
- 208000011117 substance-related disease Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 229960003086 naltrexone Drugs 0.000 abstract 4
- 239000005557 antagonist Substances 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 230000007935 neutral effect Effects 0.000 abstract 3
- 206010063659 Aversion Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
- 229940124636 opioid drug Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18937200P | 2000-03-15 | 2000-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326222T1 true ATE326222T1 (de) | 2006-06-15 |
Family
ID=22697044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01920377T ATE326222T1 (de) | 2000-03-15 | 2001-03-15 | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20010049375A1 (de) |
| EP (1) | EP1263438B1 (de) |
| AT (1) | ATE326222T1 (de) |
| AU (1) | AU4743601A (de) |
| CA (1) | CA2403252A1 (de) |
| DE (1) | DE60119696T2 (de) |
| WO (1) | WO2001068080A2 (de) |
Families Citing this family (63)
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| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| US20040024006A1 (en) * | 1996-05-06 | 2004-02-05 | Simon David Lew | Opioid pharmaceutical compositions |
| ES2412409T3 (es) | 1997-12-22 | 2013-07-11 | Euro-Celtique S.A. | Forma farmacéutica para dosificación oral que comprende una combinación de un agonista opiáceo y un antagonista opiáceo |
| DE60138706D1 (de) | 2000-02-08 | 2009-06-25 | Euro Celtique Sa | Missbrauchssichere orale opioid-agonist zubereitungen |
| US20030065002A1 (en) | 2001-05-11 | 2003-04-03 | Endo Pharmaceuticals, Inc. | Abuse-resistant controlled-release opioid dosage form |
| WO2003007802A2 (en) | 2001-07-18 | 2003-01-30 | Euro-Celtique, S.A. | Pharmaceutical combinations of oxycodone and naloxone |
| DK1414451T3 (da) | 2001-08-06 | 2009-08-10 | Euro Celtique Sa | Opioidagonistformuleringer med frigivelig og sekvenstreret antagonist |
| AU2002324624A1 (en) | 2001-08-06 | 2003-02-24 | Euro-Celtique S.A. | Sequestered antagonist formulations |
| SI1436012T1 (en) * | 2001-10-18 | 2018-03-30 | Nektar Therapeutics | Polymer conjugates of opioid antagonists |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| EP1492505B1 (de) | 2002-04-05 | 2015-06-03 | Euro-Celtique S.A. | Pharmazeutische zubereitung enthaltend oxycodon und naloxon |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EP2301537A1 (de) | 2002-05-17 | 2011-03-30 | Duke University | Zonisamid zur Behandlung von Fettleibigkeit |
| US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
| PT1551372T (pt) | 2002-09-20 | 2018-07-23 | Alpharma Pharmaceuticals Llc | Subunidade de sequestração e composições e métodos relacionados |
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| MXPA05011557A (es) * | 2003-04-29 | 2006-03-09 | Orexigen Therapeutics Inc | Composiciones para afectar perdida de peso. |
| US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| PL1694363T3 (pl) * | 2003-12-16 | 2014-07-31 | Nektar Therapeutics | Monodyspersyjne kompozycje PEGylowanego naloksolu |
| JP2007517901A (ja) * | 2004-01-13 | 2007-07-05 | デューク・ユニバーシティー | 体重の減少に作用する鎮痙剤及び抗精神病剤の組成物 |
| US7713959B2 (en) * | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| CA2565154A1 (en) * | 2004-05-03 | 2005-11-24 | Duke University | Compositions for affecting weight loss |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| CA2580694A1 (en) * | 2004-09-23 | 2006-03-30 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
| US20070197573A1 (en) * | 2005-10-04 | 2007-08-23 | Wolfgang Sadee | Compositions and methods in the treatment of bone metabolic disorders |
| CN1813740B (zh) * | 2005-11-22 | 2010-05-05 | 岳振江 | 一种含有盐酸纳洛酮的舌下膜剂及其制备方法 |
| JP5180092B2 (ja) | 2005-11-22 | 2013-04-10 | オレキシジェン・セラピューティクス・インコーポレーテッド | インスリン感受性を増すための組成物および方法 |
| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| US8916195B2 (en) | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| MX2008016372A (es) | 2006-06-19 | 2009-05-28 | Alpharma Inc | Composiciones farmaceuticas. |
| KR101654176B1 (ko) | 2006-11-09 | 2016-09-09 | 오렉시젠 세러퓨틱스 인크. | 신속하게 용해되는 중간층을 포함하는 층상의 약제학적 제형 |
| MX343867B (es) * | 2006-11-09 | 2016-11-25 | Orexigen Therapeutics Inc | Paquete de dosificacion unitaria y metodos para administrar medicaciones de perdida de peso. |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| EP2149047A4 (de) * | 2007-04-30 | 2010-05-19 | Univ Ohio State Res Found | Polymorphismen in genen mit einfluss auf dopamintransporter-erkrankungen und ihre anwendungen |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| JP2011500686A (ja) * | 2007-10-18 | 2011-01-06 | アイコ バイオテクノロジー | オピオイドと中性アンタゴニストを用いる組合せ鎮痛剤 |
| WO2009079489A1 (en) * | 2007-12-17 | 2009-06-25 | The Ohio State University Research Foundation | Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| MX2010012909A (es) | 2008-05-30 | 2011-02-25 | Orexigen Therapeutics Inc | Metodos para tratamiento de condiciones de grasa visceral. |
| BRPI1006186A2 (pt) | 2009-03-10 | 2016-08-23 | Euro Celtique Sa | composições farmaceuticas de liberação imediata compreedendo oxicodona e naloxona |
| EP2523557B1 (de) | 2010-01-11 | 2019-09-25 | Nalpropion Pharmaceuticals, Inc. | Verfahren zur bereitstellung einer gewichtsverlusttherapie für patienten mit schweren depressionen |
| WO2011139525A1 (en) * | 2010-05-05 | 2011-11-10 | Philadelphia Health & Education Corporation | Stereoisomer of naloxone and potential therapeutic action of opioid drugs to reverse clinical tolerance to these agents |
| US20130289060A1 (en) * | 2010-10-19 | 2013-10-31 | Memorial Sloan-Kettering Cancer Center | 6-AMIDO DERIVATIVES OF 4, 5-a EPOXYMORPHINANS FOR THE TREATMENT OF PAIN |
| PL4104824T3 (pl) | 2012-06-06 | 2025-11-12 | Nalpropion Pharmaceuticals Llc | Kompozycja do zastosowania w sposobie leczenia nadwagi i otyłości u pacjentów z wysokim ryzykiem sercowo-naczyniowym |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
| JP2016525138A (ja) | 2013-07-23 | 2016-08-22 | ユーロ−セルティーク エス.エイ. | 疼痛および腸内ディスバイオシスをもたらす疾患および/または腸内細菌移行に対するリスクを高める疾患に罹患している患者における痛みの治療への使用のためのオキシコドンおよびナロキソンの組み合わせ |
| PL3148517T3 (pl) | 2014-05-30 | 2021-11-29 | The Research Foundation For The State University Of New York | Kompozycje i sposoby do promowania tworzenia kości |
| EP3291676B1 (de) | 2015-04-30 | 2022-08-17 | Memorial Sloan Kettering Cancer Center | Mitragynin-analoga und verwendungen davon |
| US9861629B1 (en) | 2015-10-07 | 2018-01-09 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| DK3400066T3 (da) | 2016-01-08 | 2021-10-18 | Ohio State Innovation Foundation | Behandlinger og forebyggelse af neonatalt opioidt abstinenssyndrom |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| US20200101066A1 (en) | 2017-03-28 | 2020-04-02 | LDN Pharma Limited | Agent that increases the expression of the bcl2-associated agonist of cell death for the treatment of cancer |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| US20220047580A1 (en) * | 2019-01-04 | 2022-02-17 | Aether Therapeutics Inc. | Method for treating drug or alcohol dependency |
| WO2020178447A1 (en) * | 2019-03-06 | 2020-09-10 | LDN Pharma Limited | Method for determining efficacy |
| CN114364402A (zh) | 2019-07-15 | 2022-04-15 | 罗瓦萨公司 | 用于治疗癌症的阿片类生长因子受体(ogfr)拮抗剂,特别是纳洛酮和/或纳曲酮 |
| WO2022015364A1 (en) | 2020-07-17 | 2022-01-20 | Zetagen Therapeutics, Inc. | Methods and compositions to graft bone using iron excipients |
| EP4366736A4 (de) * | 2021-07-06 | 2025-05-14 | Aether Therapeutics Inc. | Niedrigdosiertes naltrexol und verwendungen davon |
| US11957676B1 (en) * | 2023-08-07 | 2024-04-16 | Zetagen Therapeutics, Inc. | Controlled release formulation and minimally invasive method of administration to locally treat cancer |
| US12403118B1 (en) | 2025-03-05 | 2025-09-02 | Zetagen Therapeutics, Inc. | Cancer treatments using modified fatty acids and the carriers to administer them |
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| US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
| NL280825A (de) | 1962-07-11 | |||
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| JPS523342B2 (de) | 1972-01-26 | 1977-01-27 | ||
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4689332A (en) | 1984-04-09 | 1987-08-25 | Research Corporation | Growth regulation and related applications of opioid antagonists |
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-
2001
- 2001-03-15 WO PCT/US2001/008225 patent/WO2001068080A2/en not_active Ceased
- 2001-03-15 EP EP01920377A patent/EP1263438B1/de not_active Expired - Lifetime
- 2001-03-15 AU AU4743601A patent/AU4743601A/xx active Pending
- 2001-03-15 DE DE60119696T patent/DE60119696T2/de not_active Expired - Lifetime
- 2001-03-15 US US09/809,637 patent/US20010049375A1/en not_active Abandoned
- 2001-03-15 AT AT01920377T patent/ATE326222T1/de not_active IP Right Cessation
- 2001-03-15 CA CA002403252A patent/CA2403252A1/en not_active Abandoned
-
2002
- 2002-06-14 US US10/173,337 patent/US6713488B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| WO2001068080A3 (en) | 2002-07-04 |
| US6713488B2 (en) | 2004-03-30 |
| US20010049375A1 (en) | 2001-12-06 |
| EP1263438A2 (de) | 2002-12-11 |
| DE60119696T2 (de) | 2007-01-25 |
| US20030069262A1 (en) | 2003-04-10 |
| WO2001068080A2 (en) | 2001-09-20 |
| DE60119696D1 (de) | 2006-06-22 |
| EP1263438B1 (de) | 2006-05-17 |
| CA2403252A1 (en) | 2001-09-20 |
| AU4743601A (en) | 2001-09-24 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |