ATE326222T1 - Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch - Google Patents
Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauchInfo
- Publication number
- ATE326222T1 ATE326222T1 AT01920377T AT01920377T ATE326222T1 AT E326222 T1 ATE326222 T1 AT E326222T1 AT 01920377 T AT01920377 T AT 01920377T AT 01920377 T AT01920377 T AT 01920377T AT E326222 T1 ATE326222 T1 AT E326222T1
- Authority
- AT
- Austria
- Prior art keywords
- naltrexone
- naloxone
- treatment
- analogs
- pain
- Prior art date
Links
- 238000011282 treatment Methods 0.000 title abstract 8
- UZHSEJADLWPNLE-GRGSLBFTSA-N naloxone Chemical compound O=C([C@@H]1O2)CC[C@@]3(O)[C@H]4CC5=CC=C(O)C2=C5[C@@]13CCN4CC=C UZHSEJADLWPNLE-GRGSLBFTSA-N 0.000 title abstract 6
- DQCKKXVULJGBQN-XFWGSAIBSA-N naltrexone Chemical class N1([C@@H]2CC3=CC=C(C=4O[C@@H]5[C@](C3=4)([C@]2(CCC5=O)O)CC1)O)CC1CC1 DQCKKXVULJGBQN-XFWGSAIBSA-N 0.000 title abstract 6
- 229960004127 naloxone Drugs 0.000 title abstract 4
- 206010013654 Drug abuse Diseases 0.000 title 1
- 208000011117 substance-related disease Diseases 0.000 title 1
- 229940079593 drug Drugs 0.000 abstract 4
- 239000003814 drug Substances 0.000 abstract 4
- 229960003086 naltrexone Drugs 0.000 abstract 4
- 239000005557 antagonist Substances 0.000 abstract 3
- 230000000694 effects Effects 0.000 abstract 3
- 230000007935 neutral effect Effects 0.000 abstract 3
- 206010063659 Aversion Diseases 0.000 abstract 1
- 206010010774 Constipation Diseases 0.000 abstract 1
- 208000004756 Respiratory Insufficiency Diseases 0.000 abstract 1
- 206010038678 Respiratory depression Diseases 0.000 abstract 1
- 208000007271 Substance Withdrawal Syndrome Diseases 0.000 abstract 1
- 230000002411 adverse Effects 0.000 abstract 1
- 230000000202 analgesic effect Effects 0.000 abstract 1
- 230000001684 chronic effect Effects 0.000 abstract 1
- 230000001419 dependent effect Effects 0.000 abstract 1
- 102000051367 mu Opioid Receptors Human genes 0.000 abstract 1
- 229940124636 opioid drug Drugs 0.000 abstract 1
- 238000002560 therapeutic procedure Methods 0.000 abstract 1
- 108020001612 μ-opioid receptors Proteins 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/47—Quinolines; Isoquinolines
- A61K31/485—Morphinan derivatives, e.g. morphine, codeine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/30—Drugs for disorders of the nervous system for treating abuse or dependence
- A61P25/36—Opioid-abuse
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Emergency Medicine (AREA)
- Epidemiology (AREA)
- Addiction (AREA)
- Psychiatry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Neurosurgery (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US18937200P | 2000-03-15 | 2000-03-15 |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ATE326222T1 true ATE326222T1 (de) | 2006-06-15 |
Family
ID=22697044
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| AT01920377T ATE326222T1 (de) | 2000-03-15 | 2001-03-15 | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US20010049375A1 (de) |
| EP (1) | EP1263438B1 (de) |
| AT (1) | ATE326222T1 (de) |
| AU (1) | AU4743601A (de) |
| CA (1) | CA2403252A1 (de) |
| DE (1) | DE60119696T2 (de) |
| WO (1) | WO2001068080A2 (de) |
Families Citing this family (63)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040024006A1 (en) * | 1996-05-06 | 2004-02-05 | Simon David Lew | Opioid pharmaceutical compositions |
| US20030211157A1 (en) * | 1996-05-06 | 2003-11-13 | Simon David Lew | Semi-sol delivery blend for water soluble molecules |
| EP2266564B1 (de) | 1997-12-22 | 2013-03-13 | Euro-Celtique S.A. | Peroral zu verabreichende Arzneiform enthaltend eine Kombination von einem opioid Agonisten und einem opioid Antagonisten |
| EP2517710B1 (de) | 2000-02-08 | 2015-03-25 | Euro-Celtique S.A. | Missbrauchssichere orale Opioidagonisten-Formulierungen |
| JP4522652B2 (ja) | 2001-05-11 | 2010-08-11 | エンドー ファーマシューティカルズ, インコーポレイティド | 乱用防止制御放出オピオイド投薬形態 |
| CA2454328C (en) | 2001-07-18 | 2008-03-18 | Christopher D. Breder | Pharmaceutical combinations of oxycodone and naloxone |
| US20030157168A1 (en) | 2001-08-06 | 2003-08-21 | Christopher Breder | Sequestered antagonist formulations |
| MXPA04001210A (es) | 2001-08-06 | 2004-07-08 | Euro Celtique Sa | Formulaciones de agonista opioide con antagonista liberable y aislado. |
| SI2939696T1 (sl) * | 2001-10-18 | 2016-06-30 | Nektar Therapeutics | Polimerni konjugati opioidnih antagonistov |
| DE10161963A1 (de) * | 2001-12-17 | 2003-07-03 | Johannes Schuetz | 6-Aminomorphinanderivate, Herstellungsverfahren dafür und deren Verwendung |
| US20040033253A1 (en) * | 2002-02-19 | 2004-02-19 | Ihor Shevchuk | Acyl opioid antagonists |
| LT2425824T (lt) | 2002-04-05 | 2017-07-25 | Euro-Celtique S.A. | Farmacinis preparatas, turintis oksikodono ir naloksono |
| US7501433B2 (en) * | 2002-05-17 | 2009-03-10 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| US20050215552A1 (en) * | 2002-05-17 | 2005-09-29 | Gadde Kishore M | Method for treating obesity |
| JP4545584B2 (ja) | 2002-05-17 | 2010-09-15 | デューク ユニバーシティ | 肥満を治療するための方法 |
| SI1551372T1 (en) | 2002-09-20 | 2018-08-31 | Alpharma Pharmaceuticals Llc | SUBVENCATION DATA AND RELATED CONSTRUCTIONS AND PROCEDURES |
| MY135852A (en) | 2003-04-21 | 2008-07-31 | Euro Celtique Sa | Pharmaceutical products |
| RU2350327C2 (ru) * | 2003-04-29 | 2009-03-27 | Ориксиджен Серапьютикс, Инкорпорэйтд | Составы, вызывающие потерю веса |
| US8017622B2 (en) * | 2003-05-16 | 2011-09-13 | Jenken Biosciences, Inc. | Opioid and opioid-like compounds and uses thereof |
| EA018427B1 (ru) * | 2003-12-16 | 2013-07-30 | Нектар Терапьютикс | Химически модифицированный налоксон |
| US7429580B2 (en) * | 2004-01-13 | 2008-09-30 | Orexigen Therapeutics, Inc. | Compositions of an anticonvulsant and an antipsychotic drug and methods of using the same for affecting weight loss |
| US7713959B2 (en) | 2004-01-13 | 2010-05-11 | Duke University | Compositions of an anticonvulsant and mirtazapine to prevent weight gain |
| BRPI0510593A (pt) * | 2004-05-03 | 2007-11-20 | Univ Duke | composições para afetar a perda de peso |
| US20080045610A1 (en) * | 2004-09-23 | 2008-02-21 | Alexander Michalow | Methods for regulating neurotransmitter systems by inducing counteradaptations |
| JP2008514612A (ja) * | 2004-09-23 | 2008-05-08 | ミシャロウ、アレクサンダー | 対抗適応を誘発することにより神経伝達物質系を調節する方法 |
| EP1702558A1 (de) | 2005-02-28 | 2006-09-20 | Euro-Celtique S.A. | Verfahren und Vorrichtung zur Darmtätigkeitserfassung |
| US20070197573A1 (en) * | 2005-10-04 | 2007-08-23 | Wolfgang Sadee | Compositions and methods in the treatment of bone metabolic disorders |
| EP1951212A2 (de) | 2005-11-22 | 2008-08-06 | Orexigen Therapeutics, Inc. | Zusammensetzungen und verfahren zur erhöhung der insulinsensitivität |
| CN1813740B (zh) * | 2005-11-22 | 2010-05-05 | 岳振江 | 一种含有盐酸纳洛酮的舌下膜剂及其制备方法 |
| WO2007089318A2 (en) * | 2005-11-23 | 2007-08-09 | Orexigen Therapeutics, Inc. | Compositions and methods for reducing food cravings |
| US8916195B2 (en) * | 2006-06-05 | 2014-12-23 | Orexigen Therapeutics, Inc. | Sustained release formulation of naltrexone |
| EP2719378B1 (de) | 2006-06-19 | 2016-08-31 | Alpharma Pharmaceuticals LLC | Pharmazeutische Zusammensetzungen |
| TW201811315A (zh) | 2006-11-09 | 2018-04-01 | 美商歐瑞根治療有限公司 | 層狀醫藥調配物 |
| CA2668885C (en) * | 2006-11-09 | 2016-08-02 | Orexigen Therapeutics, Inc. | Methods for administering weight loss medications |
| US11241420B2 (en) | 2007-04-11 | 2022-02-08 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20160331729A9 (en) | 2007-04-11 | 2016-11-17 | Omeros Corporation | Compositions and methods for prophylaxis and treatment of addictions |
| US20100129818A1 (en) * | 2007-04-30 | 2010-05-27 | The Ohio State University Research Foundation | Polymorphisms in Genes Affecting CYP2C9-Related Disorders and Uses Thereof |
| WO2009051824A2 (en) * | 2007-10-18 | 2009-04-23 | Aiko Biotechnology | Combination analgesic employing opioid and neutral antagonist |
| US8748448B2 (en) | 2007-10-18 | 2014-06-10 | Aiko Biotechnology | Combination analgesic employing opioid agonist and neutral antagonist |
| WO2009079489A1 (en) * | 2007-12-17 | 2009-06-25 | The Ohio State University Research Foundation | Methods for screening of opioid receptor neutral antagonists and inverse agonists and uses thereof |
| US8623418B2 (en) | 2007-12-17 | 2014-01-07 | Alpharma Pharmaceuticals Llc | Pharmaceutical composition |
| EP2303025A4 (de) | 2008-05-30 | 2012-07-04 | Orexigen Therapeutics Inc | Verfahren zur behandlung von eingeweidefettbeschwerden |
| HUE042105T2 (hu) | 2009-03-10 | 2019-06-28 | Euro Celtique Sa | Oxikodont és naloxont tartalmazó azonnali hatóanyagleadású orális gyógyászati készítmények |
| EP3659604A1 (de) * | 2010-01-11 | 2020-06-03 | Nalpropion Pharmaceuticals, Inc. | Verfahren zur bereitstellung einer gewichtsverlusttherapie für patienten mit schweren depressionen |
| WO2011139525A1 (en) * | 2010-05-05 | 2011-11-10 | Philadelphia Health & Education Corporation | Stereoisomer of naloxone and potential therapeutic action of opioid drugs to reverse clinical tolerance to these agents |
| EP2630150B1 (de) * | 2010-10-19 | 2017-04-12 | Memorial Sloan-Kettering Cancer Center | 6-amido-derivat aus 4,5-a-epoxymorphinanen zur schmerzbehandlung |
| PT3730132T (pt) | 2012-06-06 | 2022-08-16 | Nalpropion Pharmaceuticals Llc | Composição para utilização num método de tratamento de excesso de peso e obesidade em doentes com alto risco cardiovascular |
| US9938576B1 (en) | 2012-09-21 | 2018-04-10 | Ohio State Innovation Foundation | Materials and methods for determining metabolizer status in humans |
| EP3024461B1 (de) | 2013-07-23 | 2020-05-13 | Euro-Celtique S.A. | Kombination aus oxycodon und naloxon für die verwendung bei der behandlung von schmerzen bei patienten mit schmerzen und einer krankheit, die zur intestinaldysbiose und/oder erhöhung der gefahr bakterieller translokation führt |
| DK3148517T3 (da) | 2014-05-30 | 2021-07-26 | The Resaerch Foundation For The State Univ Of New York | Sammensætninger og fremgangsmåder til fremme af knogledannelse |
| EP4212532A3 (de) | 2015-04-30 | 2023-09-27 | Memorial Sloan Kettering Cancer Center | Mitragynin-analoga und verwendungen davon |
| US9943513B1 (en) | 2015-10-07 | 2018-04-17 | Banner Life Sciences Llc | Opioid abuse deterrent dosage forms |
| US10925870B2 (en) | 2016-01-08 | 2021-02-23 | Ohio State Innovation Foundation | Treatments and prevention of opioid neonatal abstinence syndrome |
| US10335405B1 (en) | 2016-05-04 | 2019-07-02 | Patheon Softgels, Inc. | Non-burst releasing pharmaceutical composition |
| KR20200072445A (ko) | 2017-03-28 | 2020-06-22 | 엘디엔 파마 리미티드 | 암의 치료를 위한 세포 사멸의 bcl2-관련 효능제의 발현을 증가시키는 제제 |
| US10335375B2 (en) | 2017-05-30 | 2019-07-02 | Patheon Softgels, Inc. | Anti-overingestion abuse deterrent compositions |
| WO2020142644A1 (en) | 2019-01-04 | 2020-07-09 | Aether Therapeutics Inc. | Method for treating drug or alcohol dependency |
| JP7502320B2 (ja) * | 2019-03-06 | 2024-06-18 | エルディーエヌ ファーマ リミテッド | 効力を判定するための方法 |
| WO2021011529A1 (en) | 2019-07-15 | 2021-01-21 | Rovaxa | Opioid growth factor receptor (ogfr) antagonists, in particular naloxone and/or naltrexone for treating cancer |
| JP7689568B2 (ja) | 2020-07-17 | 2025-06-06 | ゼタゲン セラピューティクス,インコーポレイティド | 鉄賦形剤を用いた組成物及びがん治療を含むその用途 |
| US20240325379A1 (en) * | 2021-07-06 | 2024-10-03 | Aether Therapeutics Inc. | Low-dose naltrexol and uses thereof |
| US11957676B1 (en) * | 2023-08-07 | 2024-04-16 | Zetagen Therapeutics, Inc. | Controlled release formulation and minimally invasive method of administration to locally treat cancer |
| US12403118B1 (en) | 2025-03-05 | 2025-09-02 | Zetagen Therapeutics, Inc. | Cancer treatments using modified fatty acids and the carriers to administer them |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3254088A (en) | 1961-03-14 | 1966-05-31 | Lewenstein | Morphine derivative |
| NL137652C (de) | 1962-07-11 | |||
| US3332950A (en) | 1963-03-23 | 1967-07-25 | Endo Lab | 14-hydroxydihydronormorphinone derivatives |
| BE744162A (fr) | 1969-01-16 | 1970-06-15 | Fuji Photo Film Co Ltd | Procede d'encapsulage |
| DE2010115A1 (de) | 1970-03-04 | 1971-09-16 | Farbenfabriken Bayer Ag, 5090 Leverkusen | Verfahren zur Herstellung von Mikrogranulaten |
| JPS523342B2 (de) | 1972-01-26 | 1977-01-27 | ||
| GB1413186A (en) | 1973-06-27 | 1975-11-12 | Toyo Jozo Kk | Process for encapsulation of medicaments |
| US4389330A (en) | 1980-10-06 | 1983-06-21 | Stolle Research And Development Corporation | Microencapsulation process |
| US4689332A (en) | 1984-04-09 | 1987-08-25 | Research Corporation | Growth regulation and related applications of opioid antagonists |
| US5266574A (en) | 1984-04-09 | 1993-11-30 | Ian S. Zagon | Growth regulation and related applications of opioid antagonists |
| US4889860A (en) * | 1985-09-23 | 1989-12-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4760069A (en) * | 1985-09-23 | 1988-07-26 | Nova Pharmaceutical Corporation | Oximes of oxymorphone, naltrexone and naloxone as potent, selective opioid receptor agonists and antagonists |
| US4816586A (en) | 1987-07-29 | 1989-03-28 | Regents Of The University Of Minnesota | Delta opioid receptor antagonists |
| US5019400A (en) | 1989-05-01 | 1991-05-28 | Enzytech, Inc. | Very low temperature casting of controlled release microspheres |
| US5051426A (en) | 1990-03-27 | 1991-09-24 | Parnell Pharmaceuticals, Inc. | Method for effecting withdrawal from drug dependency |
| CH683005A5 (it) * | 1991-10-30 | 1993-12-31 | Aldo Massarotti | Procedimento per la preparazione, mediante ossidazione di N-ossidi per le terapie dei tossicomani da oppiati. |
| GB9202238D0 (en) | 1992-02-03 | 1992-03-18 | Wellcome Found | Compounds |
| US5681830A (en) | 1992-02-03 | 1997-10-28 | Delta Pharmaceuticals, Inc. | Opioid compounds |
| US5656297A (en) | 1992-03-12 | 1997-08-12 | Alkermes Controlled Therapeutics, Incorporated | Modulated release from biocompatible polymers |
| US5256669A (en) | 1992-08-07 | 1993-10-26 | Aminotek Sciences, Inc. | Methods and compositions for treating acute or chronic pain and drug addiction |
| USRE36547E (en) | 1992-09-21 | 2000-02-01 | Albert Einstein College Of Medicine Of Yeshiva University | Method of simultaneously enhancing analgesic potency and attenuating dependence liability caused by exogenous and endogenous opioid agonists |
| US6007986A (en) | 1993-06-23 | 1999-12-28 | The Regents Of The University Of California | Methods for anti-addictive narcotic analgesic activity screening |
| US5882944A (en) | 1993-06-23 | 1999-03-16 | The Regents Of The University Of California | Methods for G protein coupled receptor activity screening |
| US5650173A (en) | 1993-11-19 | 1997-07-22 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of biodegradable microparticles containing a biologically active agent |
| WO1996014071A1 (es) * | 1994-11-04 | 1996-05-17 | Legarda Ibanez Juan Jose | Combinacion de farmacos como medicamento destinado a supresion de dependencia de individuos a opiaceos |
| AU5374996A (en) | 1995-03-31 | 1996-10-16 | Cantab Pharmaceuticals Research Limited | Hapten-carrier conjugates for use in drug-abuse therapy |
| US5922253A (en) | 1995-05-18 | 1999-07-13 | Alkermes Controlled Therapeutics, Inc. | Production scale method of forming microparticles |
| WO1997018781A1 (en) * | 1995-11-20 | 1997-05-29 | University Of Miami | Method of treating nicotine dependence |
| CA2220768A1 (en) * | 1996-03-13 | 1997-09-18 | Yale University | Smoking cessation treatments using naltrexone and related compounds |
| US5792477A (en) | 1996-05-07 | 1998-08-11 | Alkermes Controlled Therapeutics, Inc. Ii | Preparation of extended shelf-life biodegradable, biocompatible microparticles containing a biologically active agent |
| US5760044A (en) * | 1996-05-16 | 1998-06-02 | Archer; Sydney | Method for treating cocaine and amphetamine dependency |
| US5780479A (en) * | 1997-04-04 | 1998-07-14 | Regents Of The University Of Minnesota | Use of opioid antagonists to treat impulse-control disorders |
| EP1011671A1 (de) * | 1997-05-20 | 2000-06-28 | Yale University | Entwöhnungstherapie mit opiat- und serotoninantagonisten |
| US6194006B1 (en) | 1998-12-30 | 2001-02-27 | Alkermes Controlled Therapeutics Inc. Ii | Preparation of microparticles having a selected release profile |
| US6109269A (en) | 1999-04-30 | 2000-08-29 | Medtronic, Inc. | Method of treating addiction by brain infusion |
-
2001
- 2001-03-15 CA CA002403252A patent/CA2403252A1/en not_active Abandoned
- 2001-03-15 EP EP01920377A patent/EP1263438B1/de not_active Expired - Lifetime
- 2001-03-15 WO PCT/US2001/008225 patent/WO2001068080A2/en not_active Ceased
- 2001-03-15 DE DE60119696T patent/DE60119696T2/de not_active Expired - Lifetime
- 2001-03-15 AU AU4743601A patent/AU4743601A/xx active Pending
- 2001-03-15 US US09/809,637 patent/US20010049375A1/en not_active Abandoned
- 2001-03-15 AT AT01920377T patent/ATE326222T1/de not_active IP Right Cessation
-
2002
- 2002-06-14 US US10/173,337 patent/US6713488B2/en not_active Expired - Lifetime
Also Published As
| Publication number | Publication date |
|---|---|
| DE60119696T2 (de) | 2007-01-25 |
| US20030069262A1 (en) | 2003-04-10 |
| DE60119696D1 (de) | 2006-06-22 |
| WO2001068080A2 (en) | 2001-09-20 |
| EP1263438A2 (de) | 2002-12-11 |
| EP1263438B1 (de) | 2006-05-17 |
| AU4743601A (en) | 2001-09-24 |
| CA2403252A1 (en) | 2001-09-20 |
| US6713488B2 (en) | 2004-03-30 |
| WO2001068080A3 (en) | 2002-07-04 |
| US20010049375A1 (en) | 2001-12-06 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| DE60119696D1 (de) | Naloxon- und naltrexon-analoga in der behandlung bei drogenmissbrauch | |
| WO2003070191A3 (en) | Tamper-resistant transdermal opioid delivery devices | |
| WO2004017941A3 (en) | Transdermal dosage form comprising an active agent and a salt and free-baseform of an antagonist | |
| CA2302754A1 (en) | Noribogaine in the treatment of pain and drug addiction | |
| CY1107262T1 (el) | Θεραπεια της εξαρτησης στερησης | |
| NO20001175D0 (no) | Smertestillende blandinger omfattende anti-epileptiske forbindelser og fremgangsmÕter for anvendelse derav | |
| WO2000021515A3 (en) | Intranasal codeine for the rapid suppression of cough and rapid relief of pain | |
| WO2002058620A3 (es) | Composiciones farmaceuticas que contienen un inhibidor de cox-ii y un relajante muscular | |
| KR970009799A (ko) | 물질 남용 금단의 치료 방법 | |
| WO2001091736A3 (en) | Combinations of an endothelin receptor antagonist and an antiepileptic compound having pain alleviating properties or analgesic | |
| WO2001068125A3 (en) | Methods and compositions for the treatment and prevention of erectile dysfunction | |
| PT1656131E (pt) | Utilização de betaína para tratar claudicação intermitente | |
| BG106548A (en) | Synergistic combinations of an nk1 receptor antagonist and a gaba structural analog | |
| SE9902597D0 (sv) | New use | |
| JP2018515547A (ja) | オピオイドとn−アシルエタノールアミンの組み合わせ | |
| Komoda et al. | Enhancement of lidocaine-induced epidural anesthesia by deoxyaconitine in the rabbit | |
| WO2007059445A3 (en) | Synergistic combinations of norketamine and opioid analgesics | |
| HUP9801628A2 (hu) | Artritisz elleni gyógyászati készítmények | |
| CY2499B1 (en) | Use of nk-1 receptor antagonists for treating stress disorders. | |
| US20040198723A1 (en) | Method of treatment | |
| MD1610F1 (en) | Method of the recidivating chronic aphthous stomatitis treatment | |
| Hanks | Current Availability and Use of Morphine in Developed Countries and Relevance of Alternative Opioids to Morphine in Clinical Practice |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| RER | Ceased as to paragraph 5 lit. 3 law introducing patent treaties |