ES2692544T3 - Variantes de alfa-amilasa - Google Patents
Variantes de alfa-amilasa Download PDFInfo
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- ES2692544T3 ES2692544T3 ES12730567.0T ES12730567T ES2692544T3 ES 2692544 T3 ES2692544 T3 ES 2692544T3 ES 12730567 T ES12730567 T ES 12730567T ES 2692544 T3 ES2692544 T3 ES 2692544T3
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Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
- C12N9/2417—Alpha-amylase (3.2.1.1.) from microbiological source
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
- C12N9/14—Hydrolases (3)
- C12N9/24—Hydrolases (3) acting on glycosyl compounds (3.2)
- C12N9/2402—Hydrolases (3) acting on glycosyl compounds (3.2) hydrolysing O- and S- glycosyl compounds (3.2.1)
- C12N9/2405—Glucanases
- C12N9/2408—Glucanases acting on alpha -1,4-glucosidic bonds
- C12N9/2411—Amylases
- C12N9/2414—Alpha-amylase (3.2.1.1.)
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Y—ENZYMES
- C12Y302/00—Hydrolases acting on glycosyl compounds, i.e. glycosylases (3.2)
- C12Y302/01—Glycosidases, i.e. enzymes hydrolysing O- and S-glycosyl compounds (3.2.1)
- C12Y302/01001—Alpha-amylase (3.2.1.1)
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- Biochemistry (AREA)
- Microbiology (AREA)
- Medicinal Chemistry (AREA)
- Physics & Mathematics (AREA)
- Biophysics (AREA)
- Plant Pathology (AREA)
- Enzymes And Modification Thereof (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Detergent Compositions (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP11172251 | 2011-06-30 | ||
| EP11172251 | 2011-06-30 | ||
| PCT/EP2012/062748 WO2013001078A1 (en) | 2011-06-30 | 2012-06-29 | Alpha-amylase variants |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| ES2692544T3 true ES2692544T3 (es) | 2018-12-04 |
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| ES12730567.0T Active ES2692544T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
| ES18183123T Active ES2834102T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ES18183123T Active ES2834102T3 (es) | 2011-06-30 | 2012-06-29 | Variantes de alfa-amilasa |
Country Status (13)
| Country | Link |
|---|---|
| US (6) | US9434932B2 (https=) |
| EP (3) | EP3798303A1 (https=) |
| JP (1) | JP6204352B2 (https=) |
| KR (1) | KR20140056237A (https=) |
| CN (2) | CN103649307B (https=) |
| AU (1) | AU2012277721B2 (https=) |
| BR (1) | BR112013033782B1 (https=) |
| DK (2) | DK2726607T3 (https=) |
| ES (2) | ES2692544T3 (https=) |
| IN (1) | IN2014CN00650A (https=) |
| MX (1) | MX353621B (https=) |
| WO (1) | WO2013001078A1 (https=) |
| ZA (1) | ZA201400678B (https=) |
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| BR122020009747B1 (pt) | 2011-06-30 | 2021-07-20 | Novozymes A/S | Polipeptídeo e alfa-amilase variantes, composição detergente, e, utilização de uma alfa- amilase variante |
| US9434932B2 (en) | 2011-06-30 | 2016-09-06 | Novozymes A/S | Alpha-amylase variants |
| EP2540824A1 (en) | 2011-06-30 | 2013-01-02 | The Procter & Gamble Company | Cleaning compositions comprising amylase variants reference to a sequence listing |
| US20150132831A1 (en) | 2012-05-16 | 2015-05-14 | Novozymes A/S | Compositions Comprising Lipase and Methods of Use Thereof |
| DK4026902T3 (da) | 2012-06-08 | 2025-07-14 | Danisco Us Inc | Variante alfa-amylaser med øget aktivitet på stivelsespolymerer |
| BR112014031882A2 (pt) | 2012-06-20 | 2017-08-01 | Novozymes As | uso de um polipeptídeo isolado, polipeptídeo, composição, polinucleotídeo isolado, construto de ácido nucleico ou vetor de expressão, célula hospedeira de expressão recombinante, métodos para produção de um polipeptídeo, para melhoria do valor nutricional de uma ração animal, e para o tratamento de proteínas, uso de pelo menos um polipeptídeo, aditivo de ração animal, ração animal, e, composição detergente |
| US20150203793A1 (en) | 2012-08-22 | 2015-07-23 | Novozymes A/S | Metalloprotease from Exiguobacterium |
| MX357022B (es) | 2012-08-22 | 2018-06-25 | Novozymes As | Metaloproteasas de alicyclobacillus sp. |
| TR201910918T4 (tr) | 2012-12-07 | 2019-08-21 | Novozymes As | Bakterilerin yapışmasının önlenmesi. |
| EP2934177B1 (en) | 2012-12-21 | 2017-10-25 | Novozymes A/S | Polypeptides having protease activiy and polynucleotides encoding same |
| EP2941485B1 (en) | 2013-01-03 | 2018-02-21 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| ES2676895T5 (es) | 2013-03-11 | 2022-04-27 | Danisco Us Inc | Variantes combinatorias de alfa-amilasa |
| WO2014173980A2 (en) | 2013-04-23 | 2014-10-30 | Novozymes A/S | Liquid automatic dish washing detergent compositions |
| WO2014177709A1 (en) | 2013-05-03 | 2014-11-06 | Novozymes A/S | Microencapsulation of detergent enzymes |
| EP4717756A2 (en) | 2013-05-14 | 2026-04-01 | Novozymes A/S | Lipase variants and detergent compositions |
| CN105209613A (zh) | 2013-05-17 | 2015-12-30 | 诺维信公司 | 具有α淀粉酶活性的多肽 |
| EP3004315A2 (en) | 2013-06-06 | 2016-04-13 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| US20160145596A1 (en) | 2013-06-27 | 2016-05-26 | Novozymes A/S | Subtilase Variants and Polynucleotides Encoding Same |
| US10378001B2 (en) | 2013-06-27 | 2019-08-13 | Novozymes A/S | Subtilase variants and compositions comprising same |
| RU2015156280A (ru) | 2013-07-04 | 2017-08-09 | Новозимс А/С | Полипептиды, обладающие эффектом против переосаждения, и полинуклеотиды, кодирующие их |
| WO2015014803A1 (en) | 2013-07-29 | 2015-02-05 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| CN105358686A (zh) | 2013-07-29 | 2016-02-24 | 诺维信公司 | 蛋白酶变体以及对其进行编码的多核苷酸 |
| WO2015049370A1 (en) | 2013-10-03 | 2015-04-09 | Novozymes A/S | Detergent composition and use of detergent composition |
| EP3453757B1 (en) | 2013-12-20 | 2020-06-17 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| CN106062271A (zh) | 2014-03-05 | 2016-10-26 | 诺维信公司 | 用于改进具有木葡聚糖内糖基转移酶的纤维素纺织材料的性质的组合物和方法 |
| WO2015134729A1 (en) | 2014-03-05 | 2015-09-11 | Novozymes A/S | Compositions and methods for improving properties of non-cellulosic textile materials with xyloglucan endotransglycosylase |
| US20170015950A1 (en) | 2014-04-01 | 2017-01-19 | Novozymes A/S | Polypeptides having alpha amylase activity |
| MX376770B (es) | 2014-04-11 | 2025-03-07 | Novozymes As | Composición detergente. |
| WO2017186943A1 (en) | 2016-04-29 | 2017-11-02 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2015181118A1 (en) | 2014-05-27 | 2015-12-03 | Novozymes A/S | Methods for producing lipases |
| AR100606A1 (es) | 2014-05-27 | 2016-10-19 | Novozymes As | Variantes de lipasas y polinucleótidos que las codifican |
| WO2015189371A1 (en) | 2014-06-12 | 2015-12-17 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| CN106471110A (zh) | 2014-07-03 | 2017-03-01 | 诺维信公司 | 改进的非蛋白酶类酶稳定化 |
| EP3739029A1 (en) | 2014-07-04 | 2020-11-18 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| US10550381B2 (en) | 2014-07-04 | 2020-02-04 | Novozymes A/S | Variant proteases and amylases having enhanced storage stability |
| WO2016079110A2 (en) | 2014-11-19 | 2016-05-26 | Novozymes A/S | Use of enzyme for cleaning |
| WO2016079305A1 (en) * | 2014-11-20 | 2016-05-26 | Novozymes A/S | Alicyclobacillus variants and polynucleotides encoding same |
| CA2963331C (en) | 2014-12-04 | 2024-09-10 | Novozymes A/S | VARIANTS OF SUBTILASE AND THE POLYNUCLEOTIDES CODING FOR THESE |
| WO2016087401A1 (en) | 2014-12-05 | 2016-06-09 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| EP4530348A3 (en) | 2014-12-15 | 2025-08-06 | Basf Se | Detergent composition comprising subtilase variants |
| CN107002049A (zh) | 2014-12-16 | 2017-08-01 | 诺维信公司 | 具有n‑乙酰基葡萄糖胺氧化酶活性的多肽 |
| EP3034591A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034590A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034592A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Method of automatic dishwashing |
| EP3034589A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Detergent composition |
| PL3034588T3 (pl) | 2014-12-17 | 2019-09-30 | The Procter And Gamble Company | Kompozycja detergentu |
| EP3034597A1 (en) | 2014-12-17 | 2016-06-22 | The Procter and Gamble Company | Detergent composition |
| EP3034596B2 (en) | 2014-12-17 | 2021-11-10 | The Procter & Gamble Company | Detergent composition |
| US11518987B2 (en) | 2014-12-19 | 2022-12-06 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| US10400230B2 (en) | 2014-12-19 | 2019-09-03 | Novozymes A/S | Protease variants and polynucleotides encoding same |
| US20180112156A1 (en) | 2015-04-10 | 2018-04-26 | Novozymes A/S | Laundry method, use of polypeptide and detergent composition |
| CN107636134A (zh) | 2015-04-10 | 2018-01-26 | 诺维信公司 | 洗涤剂组合物 |
| AU2016259703B2 (en) | 2015-05-08 | 2021-12-23 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| WO2016180749A1 (en) | 2015-05-08 | 2016-11-17 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| EP3298121B1 (en) | 2015-05-19 | 2019-03-20 | Novozymes A/S | Odor reduction |
| ES2670044T3 (es) | 2015-06-04 | 2018-05-29 | The Procter & Gamble Company | Composición detergente líquida para lavado de vajillas a mano |
| EP3287513A1 (en) | 2015-06-04 | 2018-02-28 | The Procter & Gamble Company | Hand dishwashing liquid detergent composition |
| US10858637B2 (en) | 2015-06-16 | 2020-12-08 | Novozymes A/S | Polypeptides with lipase activity and polynucleotides encoding same |
| EP3310688A1 (en) | 2015-06-17 | 2018-04-25 | Novozymes A/S | Container |
| EP4071244A1 (en) | 2015-06-18 | 2022-10-12 | Novozymes A/S | Subtilase variants and polynucleotides encoding same |
| EP3106508B1 (en) | 2015-06-18 | 2019-11-20 | Henkel AG & Co. KGaA | Detergent composition comprising subtilase variants |
| CN107922896A (zh) | 2015-06-30 | 2018-04-17 | 诺维信公司 | 衣物洗涤剂组合物、用于洗涤的方法和组合物的用途 |
| MX394221B (es) | 2015-07-01 | 2025-03-24 | Novozymes As | Metodos de reduccion de olor. |
| EP3950939A3 (en) | 2015-07-06 | 2022-06-08 | Novozymes A/S | Lipase variants and polynucleotides encoding same |
| CA2991114A1 (en) | 2015-09-17 | 2017-03-23 | Novozymes A/S | Polypeptides having xanthan degrading activity and polynucleotides encoding same |
| US11053486B2 (en) | 2015-09-17 | 2021-07-06 | Henkel Ag & Co. Kgaa | Detergent compositions comprising polypeptides having xanthan degrading activity |
| EP3359657B1 (en) | 2015-10-07 | 2020-04-01 | Novozymes A/S | Polypeptides |
| EP3362558A1 (en) | 2015-10-14 | 2018-08-22 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| JP2018531783A (ja) | 2015-10-14 | 2018-11-01 | ノボザイムス アクティーゼルスカブ | 水濾過膜の洗浄 |
| EP4324919A3 (en) | 2015-10-14 | 2024-05-29 | Novozymes A/S | Polypeptide variants |
| CN108291178B (zh) | 2015-10-28 | 2020-08-04 | 诺维信公司 | 包含淀粉酶变体和蛋白酶变体的洗涤剂组合物 |
| WO2017089366A1 (en) | 2015-11-24 | 2017-06-01 | Novozymes A/S | Polypeptides having protease activity and polynucleotides encoding same |
| WO2017093318A1 (en) | 2015-12-01 | 2017-06-08 | Novozymes A/S | Methods for producing lipases |
| ES2932192T3 (es) | 2015-12-07 | 2023-01-16 | Henkel Ag & Co Kgaa | Composiciones para el lavado de vajilla que comprenden polipéptidos que tienen actividad beta-glucanasa y sus usos |
| EP3397061A1 (en) | 2015-12-28 | 2018-11-07 | Novozymes BioAG A/S | Heat priming of bacterial spores |
| MX2018008051A (es) | 2016-01-29 | 2018-08-23 | Novozymes As | Variantes de beta-glucanasa y polinucleotidos que las codifican. |
| WO2017162836A1 (en) | 2016-03-23 | 2017-09-28 | Novozymes A/S | Use of polypeptide having dnase activity for treating fabrics |
| EP3440180B1 (en) | 2016-04-08 | 2020-11-11 | Novozymes A/S | Detergent compositions and uses of the same |
| WO2017210188A1 (en) | 2016-05-31 | 2017-12-07 | Novozymes A/S | Stabilized liquid peroxide compositions |
| CN109715792A (zh) | 2016-06-03 | 2019-05-03 | 诺维信公司 | 枯草杆菌酶变体和对其进行编码的多核苷酸 |
| EP3257931A1 (en) | 2016-06-17 | 2017-12-20 | The Procter and Gamble Company | Detergent composition |
| EP3475404A1 (en) | 2016-06-23 | 2019-05-01 | Novozymes A/S | Use of enzymes, composition and method for removing soil |
| US11203732B2 (en) | 2016-06-30 | 2021-12-21 | Novozymes A/S | Lipase variants and compositions comprising surfactant and lipase variant |
| WO2018002261A1 (en) | 2016-07-01 | 2018-01-04 | Novozymes A/S | Detergent compositions |
| WO2018007573A1 (en) | 2016-07-08 | 2018-01-11 | Novozymes A/S | Detergent compositions with galactanase |
| CA3027272C (en) | 2016-07-13 | 2022-06-21 | The Procter & Gamble Company | Bacillus cibi dnase variants and uses thereof |
| EP3485008B1 (en) | 2016-07-18 | 2024-01-31 | Novozymes A/S | Lipase variants, polynucleotides encoding same and the use thereof |
| ES2790148T3 (es) | 2016-08-17 | 2020-10-27 | Procter & Gamble | Composición limpiadora que comprende enzimas |
| WO2018060475A1 (en) | 2016-09-29 | 2018-04-05 | Novozymes A/S | Spore containing granule |
| CN110023474A (zh) | 2016-09-29 | 2019-07-16 | 诺维信公司 | 酶用于洗涤的用途、洗涤方法和器皿洗涤组合物 |
| US20210284933A1 (en) | 2016-10-25 | 2021-09-16 | Novozymes A/S | Detergent compositions |
| CN110072986B (zh) | 2016-11-01 | 2023-04-04 | 诺维信公司 | 多核心颗粒 |
| EP3548615A1 (en) * | 2016-11-29 | 2019-10-09 | Novozymes A/S | Alpha-amylase variants and polynucleotides encoding same |
| MX2019006425A (es) | 2016-12-01 | 2019-08-14 | Basf Se | Estabilizacion de enzimas en composiciones. |
| EP3551740B1 (en) | 2016-12-12 | 2021-08-11 | Novozymes A/S | Use of polypeptides |
| US12071643B2 (en) * | 2017-02-01 | 2024-08-27 | Novozymes A/S | Alpha-amylase variants |
| ES2965826T3 (es) * | 2017-02-01 | 2024-04-17 | Procter & Gamble | Composiciones limpiadoras que comprenden variantes de amilasa |
| CN110651040A (zh) | 2017-03-31 | 2020-01-03 | 诺维信公司 | 具有dna酶活性的多肽 |
| WO2018177936A1 (en) | 2017-03-31 | 2018-10-04 | Novozymes A/S | Polypeptides having dnase activity |
| US11149233B2 (en) | 2017-03-31 | 2021-10-19 | Novozymes A/S | Polypeptides having RNase activity |
| US11208639B2 (en) | 2017-03-31 | 2021-12-28 | Novozymes A/S | Polypeptides having DNase activity |
| US20200109388A1 (en) | 2017-04-03 | 2020-04-09 | Novozymes A/S | Recovery Process |
| EP3607040A1 (en) | 2017-04-04 | 2020-02-12 | Novozymes A/S | Polypeptide compositions and uses thereof |
| CN114480034A (zh) | 2017-04-04 | 2022-05-13 | 诺维信公司 | 糖基水解酶 |
| EP3607039A1 (en) | 2017-04-04 | 2020-02-12 | Novozymes A/S | Polypeptides |
| EP3385362A1 (en) | 2017-04-05 | 2018-10-10 | Henkel AG & Co. KGaA | Detergent compositions comprising fungal mannanases |
| ES2728758T3 (es) | 2017-04-05 | 2019-10-28 | Henkel Ag & Co Kgaa | Composiciones de detergente que comprenden mananasas bacterianas |
| WO2018184818A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| US20200190438A1 (en) | 2017-04-06 | 2020-06-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018184816A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3478811B1 (en) | 2017-04-06 | 2019-10-16 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2018185269A1 (en) | 2017-04-06 | 2018-10-11 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3607044B1 (en) | 2017-04-06 | 2024-11-13 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3967756B1 (en) | 2017-04-06 | 2025-03-05 | Novozymes A/S | Detergent compositions and uses thereof |
| MX2019011764A (es) | 2017-04-06 | 2019-11-28 | Novozymes As | Composiciones limpiadoras y usos de las mismas. |
| WO2018202846A1 (en) | 2017-05-05 | 2018-11-08 | Novozymes A/S | Compositions comprising lipase and sulfite |
| WO2018224544A1 (en) | 2017-06-08 | 2018-12-13 | Novozymes A/S | Compositions comprising polypeptides having cellulase activity and amylase activity, and uses thereof in cleaning and detergent compositions |
| EP3645692B1 (en) | 2017-06-30 | 2025-12-31 | Novozymes A/S | ENZYMATIC SUSPENSION COMPOSITION |
| WO2019057758A1 (en) | 2017-09-20 | 2019-03-28 | Novozymes A/S | USE OF ENZYMES TO ENHANCE WATER ABSORPTION AND / OR WHITENESS |
| EP3684899A1 (en) | 2017-09-22 | 2020-07-29 | Novozymes A/S | Novel polypeptides |
| EP4567094A3 (en) | 2017-09-27 | 2026-01-07 | Novozymes A/S | Lipase variants and microcapsule compositions comprising such lipase variants |
| JP7114697B2 (ja) | 2017-09-27 | 2022-08-08 | ザ プロクター アンド ギャンブル カンパニー | リパーゼを含む洗剤組成物 |
| CN111373036A (zh) | 2017-10-02 | 2020-07-03 | 诺维信公司 | 具有甘露聚糖酶活性的多肽和编码它们的多核苷酸 |
| US11746310B2 (en) | 2017-10-02 | 2023-09-05 | Novozymes A/S | Polypeptides having mannanase activity and polynucleotides encoding same |
| CN111542589A (zh) | 2017-10-16 | 2020-08-14 | 诺维信公司 | 低粉化颗粒 |
| WO2019076800A1 (en) | 2017-10-16 | 2019-04-25 | Novozymes A/S | CLEANING COMPOSITIONS AND USES THEREOF |
| EP3697881B1 (en) | 2017-10-16 | 2024-12-18 | Novozymes A/S | Low dusting granules |
| WO2019081515A1 (en) | 2017-10-24 | 2019-05-02 | Novozymes A/S | COMPOSITIONS COMPRISING POLYPEPTIDES HAVING MANNANASE ACTIVITY |
| HUE057832T2 (hu) | 2017-10-27 | 2022-06-28 | Procter & Gamble | Polipeptid-variánsokat tartalmazó mosószerkészítmények |
| EP3701017A1 (en) | 2017-10-27 | 2020-09-02 | Novozymes A/S | Dnase variants |
| EP3704240A1 (en) | 2017-11-01 | 2020-09-09 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| EP3704220B1 (en) | 2017-11-01 | 2026-04-15 | Novozymes A/S | Methods for cleaning medical devices |
| DE102017125560A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine iii enthalten |
| WO2019086530A1 (en) | 2017-11-01 | 2019-05-09 | Novozymes A/S | Polypeptides and compositions comprising such polypeptides |
| DE102017125559A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine ii enthalten |
| DE102017125558A1 (de) | 2017-11-01 | 2019-05-02 | Henkel Ag & Co. Kgaa | Reinigungszusammensetzungen, die dispersine i enthalten |
| CN111465680A (zh) | 2017-11-29 | 2020-07-28 | 巴斯夫欧洲公司 | 组合物、其制备和用途 |
| CN111670248A (zh) | 2017-12-04 | 2020-09-15 | 诺维信公司 | 脂肪酶变体以及编码其的多核苷酸 |
| WO2019154951A1 (en) | 2018-02-08 | 2019-08-15 | Novozymes A/S | Lipases, lipase variants and compositions thereof |
| EP3749759A1 (en) | 2018-02-08 | 2020-12-16 | Novozymes A/S | Lipase variants and compositions thereof |
| US20210002588A1 (en) | 2018-03-13 | 2021-01-07 | Novozymes A/S | Microencapsulation Using Amino Sugar Oligomers |
| WO2019180111A1 (en) | 2018-03-23 | 2019-09-26 | Novozymes A/S | Subtilase variants and compositions comprising same |
| EP3781660A1 (en) | 2018-04-17 | 2021-02-24 | Novozymes A/S | Polypeptides comprising carbohydrate binding activity in detergent compositions and their use in reducing wrinkles in textile or fabric |
| CN118460512A (zh) | 2018-04-19 | 2024-08-09 | 诺维信公司 | 稳定化的纤维素酶变体 |
| EP3781680A1 (en) | 2018-04-19 | 2021-02-24 | Novozymes A/S | Stabilized cellulase variants |
| US11732250B2 (en) | 2018-04-26 | 2023-08-22 | Basf Se | Lipase enzymes |
| WO2019211143A1 (en) | 2018-05-03 | 2019-11-07 | Basf Se | Amylase enzymes |
| WO2019238761A1 (en) | 2018-06-15 | 2019-12-19 | Basf Se | Water soluble multilayer films containing wash active chemicals and enzymes |
| EP3814472A1 (en) | 2018-06-28 | 2021-05-05 | Novozymes A/S | Detergent compositions and uses thereof |
| EP3814473A1 (en) | 2018-06-29 | 2021-05-05 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2020002255A1 (en) | 2018-06-29 | 2020-01-02 | Novozymes A/S | Subtilase variants and compositions comprising same |
| US12012573B2 (en) | 2018-07-02 | 2024-06-18 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3818138B1 (en) | 2018-07-03 | 2025-05-14 | Henkel AG & Co. KGaA | Cleaning compositions and uses thereof |
| WO2020008024A1 (en) | 2018-07-06 | 2020-01-09 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP3818140A1 (en) | 2018-07-06 | 2021-05-12 | Novozymes A/S | Cleaning compositions and uses thereof |
| WO2020070063A2 (en) | 2018-10-01 | 2020-04-09 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2020070014A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition comprising anionic surfactant and a polypeptide having rnase activity |
| WO2020070209A1 (en) | 2018-10-02 | 2020-04-09 | Novozymes A/S | Cleaning composition |
| EP3861094A1 (en) | 2018-10-02 | 2021-08-11 | Novozymes A/S | Cleaning composition |
| CN112969788A (zh) | 2018-10-02 | 2021-06-15 | 诺维信公司 | 用于清洁的核酸内切酶1核糖核酸酶 |
| WO2020070249A1 (en) | 2018-10-03 | 2020-04-09 | Novozymes A/S | Cleaning compositions |
| WO2020070199A1 (en) | 2018-10-03 | 2020-04-09 | Novozymes A/S | Polypeptides having alpha-mannan degrading activity and polynucleotides encoding same |
| US20210395651A1 (en) | 2018-10-05 | 2021-12-23 | Basf Se | Compounds stabilizing hydrolases in liquids |
| BR112021005412A2 (pt) | 2018-10-05 | 2021-06-15 | Basf Se | preparação de enzima, processo para fabricar uma preparação de enzima estável, métodos para reduzir a perda da atividade proteolítica, para preparação de uma formulação detergente, para remover manchas e para aumentar a estabilidade na armazenagem de uma formulação detergente líquida, usos de um composto e da preparação de enzima, e, formulação detergente |
| EP3677676A1 (en) | 2019-01-03 | 2020-07-08 | Basf Se | Compounds stabilizing amylases in liquids |
| CN112805377A (zh) | 2018-10-05 | 2021-05-14 | 巴斯夫欧洲公司 | 在液体中稳定淀粉酶的化合物 |
| CN112996894A (zh) | 2018-10-11 | 2021-06-18 | 诺维信公司 | 清洁组合物及其用途 |
| EP3647397A1 (en) | 2018-10-31 | 2020-05-06 | Henkel AG & Co. KGaA | Cleaning compositions containing dispersins iv |
| EP3647398B1 (en) | 2018-10-31 | 2024-05-15 | Henkel AG & Co. KGaA | Cleaning compositions containing dispersins v |
| CN113302270A (zh) | 2018-12-03 | 2021-08-24 | 诺维信公司 | 低pH粉末洗涤剂组合物 |
| EP3891277A1 (en) | 2018-12-03 | 2021-10-13 | Novozymes A/S | Powder detergent compositions |
| CN113366103A (zh) | 2018-12-21 | 2021-09-07 | 诺维信公司 | 具有肽聚糖降解活性的多肽以及编码其的多核苷酸 |
| EP3898919A1 (en) | 2018-12-21 | 2021-10-27 | Novozymes A/S | Detergent pouch comprising metalloproteases |
| WO2020169564A1 (en) | 2019-02-20 | 2020-08-27 | Basf Se | Industrial fermentation process for bacillus using defined medium and trace element feed |
| CN114096676A (zh) | 2019-02-20 | 2022-02-25 | 巴斯夫欧洲公司 | 用确定成分培养基和镁补料的芽孢杆菌工业发酵工艺 |
| EP3702452A1 (en) | 2019-03-01 | 2020-09-02 | Novozymes A/S | Detergent compositions comprising two proteases |
| JP7725365B2 (ja) | 2019-03-21 | 2025-08-19 | ノボザイムス アクティーゼルスカブ | α－アミラーゼ変異体及びこれをコードするポリヌクレオチド |
| US12606809B2 (en) | 2019-03-25 | 2026-04-21 | Basf Se | Amylase enzymes |
| WO2020193532A1 (en) | 2019-03-25 | 2020-10-01 | Basf Se | Cleaning composition having amylase enzymes |
| EP3947665A2 (en) | 2019-03-25 | 2022-02-09 | Basf Se | Amylase enzymes |
| WO2020201403A1 (en) | 2019-04-03 | 2020-10-08 | Novozymes A/S | Polypeptides having beta-glucanase activity, polynucleotides encoding same and uses thereof in cleaning and detergent compositions |
| US12247237B2 (en) | 2019-04-10 | 2025-03-11 | Novozymes A/S | Polypeptide variants |
| WO2020208056A1 (en) | 2019-04-12 | 2020-10-15 | Novozymes A/S | Stabilized glycoside hydrolase variants |
| WO2020229480A1 (en) | 2019-05-14 | 2020-11-19 | Basf Se | Compounds stabilizing hydrolases in liquids |
| US12146171B2 (en) | 2019-06-13 | 2024-11-19 | Basf Se | Method of recovering a protein from fermentation broth using a divalent cation |
| WO2020260223A1 (en) * | 2019-06-24 | 2020-12-30 | Novozymes A/S | Alpha-amylase variants |
| EP3994255A1 (en) | 2019-07-02 | 2022-05-11 | Novozymes A/S | Lipase variants and compositions thereof |
| WO2021004830A1 (en) | 2019-07-05 | 2021-01-14 | Basf Se | Industrial fermentation process for microbial cells using a fed-batch pre-culture |
| EP3997202A1 (en) | 2019-07-12 | 2022-05-18 | Novozymes A/S | Enzymatic emulsions for detergents |
| CN114364795A (zh) | 2019-08-22 | 2022-04-15 | 巴斯夫欧洲公司 | 淀粉酶变体 |
| WO2021037878A1 (en) | 2019-08-27 | 2021-03-04 | Novozymes A/S | Composition comprising a lipase |
| CN114787329A (zh) | 2019-08-27 | 2022-07-22 | 诺维信公司 | 洗涤剂组合物 |
| EP4031644A1 (en) | 2019-09-19 | 2022-07-27 | Novozymes A/S | Detergent composition |
| WO2021064068A1 (en) | 2019-10-03 | 2021-04-08 | Novozymes A/S | Polypeptides comprising at least two carbohydrate binding domains |
| BR112022006082A2 (pt) | 2019-10-18 | 2022-06-21 | Basf Se | Preparação enzimática, formulação de detergente, e, uso de pelo menos um diol |
| US12410385B2 (en) * | 2019-10-24 | 2025-09-09 | The Procter & Gamble Company | Automatic dishwashing detergent composition comprising an amylase |
| WO2021105336A1 (en) | 2019-11-29 | 2021-06-03 | Basf Se | Compositions comprising polymer and enzyme |
| WO2021115912A1 (en) | 2019-12-09 | 2021-06-17 | Basf Se | Formulations comprising a hydrophobically modified polyethyleneimine and one or more enzymes |
| WO2021123184A2 (en) * | 2019-12-19 | 2021-06-24 | Novozymes A/S | Alpha-amylase variants |
| KR20220119609A (ko) | 2019-12-20 | 2022-08-30 | 헨켈 아게 운트 코. 카게아아 | 디스페르신 vi을 포함하는 세정 조성물 |
| US20220411773A1 (en) | 2019-12-20 | 2022-12-29 | Novozymes A/S | Polypeptides having proteolytic activity and use thereof |
| EP4077617B1 (en) | 2019-12-20 | 2026-03-18 | Novozymes A/S | Stabilized liquid boron-free enzyme compositions |
| WO2021122120A2 (en) | 2019-12-20 | 2021-06-24 | Henkel Ag & Co. Kgaa | Cleaning compositions comprising dispersins viii |
| WO2021122117A1 (en) | 2019-12-20 | 2021-06-24 | Henkel Ag & Co. Kgaa | Cleaning composition coprising a dispersin and a carbohydrase |
| WO2021151536A1 (en) | 2020-01-29 | 2021-08-05 | Unilever Ip Holdings B.V. | Laundry detergent product |
| EP4097227A1 (en) | 2020-01-31 | 2022-12-07 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| WO2021152120A1 (en) | 2020-01-31 | 2021-08-05 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| EP3892708A1 (en) | 2020-04-06 | 2021-10-13 | Henkel AG & Co. KGaA | Cleaning compositions comprising dispersin variants |
| WO2021204838A1 (en) | 2020-04-08 | 2021-10-14 | Novozymes A/S | Carbohydrate binding module variants |
| US20230167384A1 (en) | 2020-04-21 | 2023-06-01 | Novozymes A/S | Cleaning compositions comprising polypeptides having fructan degrading activity |
| EP3907271A1 (en) | 2020-05-07 | 2021-11-10 | Novozymes A/S | Cleaning composition, use and method of cleaning |
| EP4158011A1 (en) | 2020-05-26 | 2023-04-05 | Novozymes A/S | Subtilase variants and compositions comprising same |
| EP4172298A1 (en) | 2020-06-24 | 2023-05-03 | Novozymes A/S | Use of cellulases for removing dust mite from textile |
| EP3936593A1 (en) | 2020-07-08 | 2022-01-12 | Henkel AG & Co. KGaA | Cleaning compositions and uses thereof |
| WO2022008732A1 (en) | 2020-07-10 | 2022-01-13 | Basf Se | Enhancing the activity of antimicrobial preservatives |
| WO2022023250A1 (en) | 2020-07-27 | 2022-02-03 | Unilever Ip Holdings B.V. | Use of an enzyme and surfactant for inhibiting microorganisms |
| EP4204551B1 (en) | 2020-08-25 | 2025-09-17 | Novozymes A/S | Variants of a family 44 xyloglucanase |
| WO2022043563A1 (en) | 2020-08-28 | 2022-03-03 | Novozymes A/S | Polyester degrading protease variants |
| CN116113329A (zh) | 2020-09-15 | 2023-05-12 | 诺维信公司 | 包含昆虫或昆虫粉的动物饲料 |
| MX2023003275A (es) | 2020-09-22 | 2023-04-12 | Basf Se | Combinacion mejorada de proteasa e inhibidor de proteasa con enzima secundaria. |
| US20240052270A1 (en) | 2020-09-22 | 2024-02-15 | Basf Se | Liquid composition comprising peptide aldehyde |
| US20250346879A1 (en) | 2020-10-07 | 2025-11-13 | Novozymes A/S | Alpha-amylase variants |
| WO2022084303A2 (en) | 2020-10-20 | 2022-04-28 | Novozymes A/S | Use of polypeptides having dnase activity |
| WO2022090320A1 (en) | 2020-10-28 | 2022-05-05 | Novozymes A/S | Use of lipoxygenase |
| JP2023547450A (ja) | 2020-10-29 | 2023-11-10 | ノボザイムス アクティーゼルスカブ | リパーゼ変異体及びそのようなリパーゼ変異体を含む組成物 |
| EP4244325A1 (en) | 2020-11-13 | 2023-09-20 | Novozymes A/S | Detergent composition comprising a lipase |
| WO2022106404A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of proteases |
| WO2022106400A1 (en) | 2020-11-18 | 2022-05-27 | Novozymes A/S | Combination of immunochemically different proteases |
| EP4015629A1 (en) | 2020-12-18 | 2022-06-22 | Basf Se | Polymer mixtures for increasing stability and performance of hydrolase-containing detergents |
| EP4032966A1 (en) | 2021-01-22 | 2022-07-27 | Novozymes A/S | Liquid enzyme composition with sulfite scavenger |
| US20240124805A1 (en) | 2021-01-28 | 2024-04-18 | Novozymes A/S | Lipase with low malodor generation |
| US20250075152A1 (en) | 2021-02-12 | 2025-03-06 | Novozymes A/S | Stabilized biological detergents |
| EP4291646A2 (en) | 2021-02-12 | 2023-12-20 | Novozymes A/S | Alpha-amylase variants |
| MX2023009756A (es) | 2021-02-22 | 2023-09-04 | Basf Se | Variantes de amilasa. |
| EP4047088A1 (en) | 2021-02-22 | 2022-08-24 | Basf Se | Amylase variants |
| EP4305146A1 (en) | 2021-03-12 | 2024-01-17 | Novozymes A/S | Polypeptide variants |
| EP4060036A1 (en) | 2021-03-15 | 2022-09-21 | Novozymes A/S | Polypeptide variants |
| WO2022194673A1 (en) | 2021-03-15 | 2022-09-22 | Novozymes A/S | Dnase variants |
| WO2022199418A1 (en) | 2021-03-26 | 2022-09-29 | Novozymes A/S | Detergent composition with reduced polymer content |
| EP4359518A1 (en) | 2021-06-23 | 2024-05-01 | Novozymes A/S | Alpha-amylase polypeptides |
| WO2023114793A1 (en) * | 2021-12-16 | 2023-06-22 | The Procter & Gamble Company | Home care composition |
| CN118369413A (zh) * | 2021-12-16 | 2024-07-19 | 宝洁公司 | 包含淀粉酶的家庭护理组合物 |
| CN118871559A (zh) | 2021-12-21 | 2024-10-29 | 诺维信公司 | 包含脂肪酶和加强剂的组合物 |
| WO2023117888A1 (en) | 2021-12-21 | 2023-06-29 | Basf Se | Chemical product passport for emission data |
| EP4206309A1 (en) | 2021-12-30 | 2023-07-05 | Novozymes A/S | Protein particles with improved whiteness |
| EP4234664A1 (en) | 2022-02-24 | 2023-08-30 | Evonik Operations GmbH | Composition comprising glucolipids and enzymes |
| US20250179393A1 (en) | 2022-03-02 | 2025-06-05 | Novozymes A/S | Use of xyloglucanase for improvement of sustainability of detergents |
| WO2023165950A1 (en) | 2022-03-04 | 2023-09-07 | Novozymes A/S | Dnase variants and compositions |
| EP4504885A1 (en) | 2022-04-08 | 2025-02-12 | Novozymes A/S | Hexosaminidase variants and compositions |
| EP4525615A2 (en) | 2022-05-14 | 2025-03-26 | Novozymes A/S | Compositions and methods for preventing, treating, supressing and/or eliminating phytopathogenic infestations and infections |
| WO2023233025A1 (en) | 2022-06-03 | 2023-12-07 | Unilever Ip Holdings B.V. | Liquid detergent product |
| WO2023247348A1 (en) | 2022-06-21 | 2023-12-28 | Novozymes A/S | Mannanase variants and polynucleotides encoding same |
| EP4544015A2 (en) | 2022-06-24 | 2025-04-30 | Novozymes A/S | Lipase variants and compositions comprising such lipase variants |
| CN119585409A (zh) | 2022-07-15 | 2025-03-07 | 巴斯夫欧洲公司 | 用于液体配制品中酶稳定的烷醇胺甲酸盐 |
| JP2025526736A (ja) | 2022-08-11 | 2025-08-15 | ビーエーエスエフ ソシエタス・ヨーロピア | アミラーゼバリアント |
| JP2025526738A (ja) | 2022-08-11 | 2025-08-15 | ビーエーエスエフ ソシエタス・ヨーロピア | アミラーゼバリアント |
| EP4612286A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2024094735A1 (en) | 2022-11-04 | 2024-05-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4612285A1 (en) | 2022-11-04 | 2025-09-10 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4630529A1 (en) | 2022-12-05 | 2025-10-15 | Novozymes A/S | A composition comprising a lipase and a peptide |
| JP2026508744A (ja) | 2022-12-05 | 2026-03-12 | ノボザイムス アクティーゼルスカブ | プロテアーゼバリアント、及びそれをコードするポリヌクレオチド |
| CN120265743A (zh) | 2022-12-14 | 2025-07-04 | 诺维信公司 | 改善的脂肪酶（gcl1）变体 |
| EP4389864A1 (en) | 2022-12-20 | 2024-06-26 | Basf Se | Cutinases |
| CN120344647A (zh) | 2022-12-23 | 2025-07-18 | 诺维信公司 | 包含过氧化氢酶和淀粉酶的洗涤剂组合物 |
| WO2024146919A1 (en) | 2023-01-05 | 2024-07-11 | Basf Se | Use of foldases to improve heterologous expression of secreted molecules |
| EP4655371A1 (en) | 2023-01-23 | 2025-12-03 | Novozymes A/S | Cleaning compositions and uses thereof |
| EP4683990A1 (en) | 2023-03-21 | 2026-01-28 | Novozymes A/S | Detergent compositions based on biosurfactants |
| WO2024213513A1 (en) | 2023-04-12 | 2024-10-17 | Novozymes A/S | Compositions comprising polypeptides having alkaline phosphatase activity |
| EP4695330A1 (en) | 2023-04-14 | 2026-02-18 | Basf Se | Porous starch |
| EP4702114A2 (en) | 2023-04-26 | 2026-03-04 | Novozymes A/S | Cleaning composition and cleaning method |
| EP4461796A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| EP4461795A1 (en) | 2023-05-10 | 2024-11-13 | Novozymes A/S | Detergent composition comprising laccase |
| WO2024231483A1 (en) | 2023-05-11 | 2024-11-14 | Novozymes A/S | Automatic dishwashing detergent compositions comprising a lipase |
| CN121335969A (zh) | 2023-06-13 | 2026-01-13 | 巴斯夫欧洲公司 | 包含edds和酶的稳定的清洁组合物及其用途 |
| WO2025002934A1 (en) | 2023-06-28 | 2025-01-02 | Novozymes A/S | Detergent composition comprising lipases |
| CN121420051A (zh) | 2023-07-07 | 2026-01-27 | 诺维信公司 | 用于去除蛋白质污渍的洗涤方法 |
| WO2025036643A1 (en) | 2023-08-15 | 2025-02-20 | Evonik Operations Gmbh | Biosurfactant for washing wool |
| WO2025088003A1 (en) | 2023-10-24 | 2025-05-01 | Novozymes A/S | Use of xyloglucanase for replacement of optical brightener |
| WO2025093368A1 (en) | 2023-11-02 | 2025-05-08 | Basf Se | Enzyme stabilization in compositions containing a protease inhibitor |
| WO2025103765A1 (en) | 2023-11-17 | 2025-05-22 | Novozymes A/S | Lytic polysaccharide monooxygenases and their use in detergent |
| WO2025114053A1 (en) | 2023-11-30 | 2025-06-05 | Novozymes A/S | Biopolymers for use in detergent |
| WO2025132258A1 (en) | 2023-12-20 | 2025-06-26 | Basf Se | Stabilized enzyme composition comprising a protease |
| WO2025153046A1 (en) | 2024-01-19 | 2025-07-24 | Novozymes A/S | Detergent compositions and uses thereof |
| WO2025202372A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202379A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202369A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202374A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025202370A1 (en) | 2024-03-27 | 2025-10-02 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| EP4624572A1 (en) | 2024-03-27 | 2025-10-01 | Basf Se | Polypeptides having protease activity for use in detergent compositions |
| WO2025257254A1 (en) | 2024-06-12 | 2025-12-18 | Novozymes A/S | Lipases and lipase variants and the use thereof |
| WO2026017636A1 (en) | 2024-07-17 | 2026-01-22 | Novozymes A/S | Compositions comprising combination of enzymes |
| EP4692292A1 (en) | 2024-08-06 | 2026-02-11 | Evonik Operations GmbH | Improved method for germinating bacterial spores |
| WO2026032785A1 (en) | 2024-08-06 | 2026-02-12 | Evonik Operations Gmbh | Bacillus licheniformis strains in cleaning and animal feeding |
| WO2026046881A1 (en) | 2024-08-26 | 2026-03-05 | Novozymes A/S | Compositions comprising a hexosaminidase and a protease |
| WO2026068782A1 (en) | 2024-09-30 | 2026-04-02 | Novozymes A/S | Protease variants and polynucleotides encoding same |
Family Cites Families (198)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB1296839A (https=) | 1969-05-29 | 1972-11-22 | ||
| GB1372034A (en) | 1970-12-31 | 1974-10-30 | Unilever Ltd | Detergent compositions |
| US3912590A (en) | 1973-01-03 | 1975-10-14 | Novo Industri As | Procedure for liquefying starch |
| FR2226460B1 (https=) | 1973-04-20 | 1976-12-17 | Interox | |
| US4105827A (en) | 1973-04-20 | 1978-08-08 | Interox | Particulate peroxygen compounds coated with sodium sesquicarbonate or Na2 SO4 mNa2 CO3 |
| GB1590432A (en) | 1976-07-07 | 1981-06-03 | Novo Industri As | Process for the production of an enzyme granulate and the enzyme granuate thus produced |
| US4316956A (en) | 1980-02-06 | 1982-02-23 | Novo Industri A/S | Fermentation process |
| US4335208A (en) | 1980-03-11 | 1982-06-15 | Novo Industri A/S | Saccharification of starch hydrolysates |
| DK187280A (da) | 1980-04-30 | 1981-10-31 | Novo Industri As | Ruhedsreducerende middel til et fuldvaskemiddel fuldvaskemiddel og fuldvaskemetode |
| FR2498783B1 (fr) | 1981-01-23 | 1988-03-04 | Decis Mario | Dispositif de controle automatique de presence |
| JPS57174089A (en) | 1981-04-20 | 1982-10-26 | Novo Industri As | Chain dividing enzyme product |
| FR2543181B1 (fr) | 1983-03-22 | 1985-07-26 | Ugine Kuhlmann | Procede ameliore de desencollage-blanchiment simultane des tissus |
| US4519934A (en) | 1983-04-19 | 1985-05-28 | Novo Industri A/S | Liquid enzyme concentrates containing alpha-amylase |
| DK263584D0 (da) | 1984-05-29 | 1984-05-29 | Novo Industri As | Enzymholdige granulater anvendt som detergentadditiver |
| US4689297A (en) | 1985-03-05 | 1987-08-25 | Miles Laboratories, Inc. | Dust free particulate enzyme formulation |
| US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
| JPH0697997B2 (ja) | 1985-08-09 | 1994-12-07 | ギスト ブロカデス ナ−ムロ−ゼ フエンノ−トチヤツプ | 新規の酵素的洗浄剤添加物 |
| DK122686D0 (da) | 1986-03-17 | 1986-03-17 | Novo Industri As | Fremstilling af proteiner |
| DK311186D0 (da) | 1986-06-30 | 1986-06-30 | Novo Industri As | Enzymer |
| FI89076C (fi) | 1986-07-09 | 1993-08-10 | Novo Nordisk As | Alfa-amylasblandningar foer att oeverfoera staerkelse i vaetskeform och foerfarande foer oeverfoering av staerkelse i flytande form |
| DE3750450T2 (de) | 1986-08-29 | 1995-01-05 | Novo Industri As | Enzymhaltiger Reinigungsmittelzusatz. |
| NZ221627A (en) | 1986-09-09 | 1993-04-28 | Genencor Inc | Preparation of enzymes, modifications, catalytic triads to alter ratios or transesterification/hydrolysis ratios |
| EP0305216B1 (en) | 1987-08-28 | 1995-08-02 | Novo Nordisk A/S | Recombinant Humicola lipase and process for the production of recombinant humicola lipases |
| JPS6474992A (en) | 1987-09-16 | 1989-03-20 | Fuji Oil Co Ltd | Dna sequence, plasmid and production of lipase |
| DK6488D0 (da) | 1988-01-07 | 1988-01-07 | Novo Industri As | Enzymer |
| DE68924654T2 (de) | 1988-01-07 | 1996-04-04 | Novonordisk As | Spezifische Protease. |
| US6287841B1 (en) | 1988-02-11 | 2001-09-11 | Genencor International, Inc. | High alkaline serine protease |
| CN1056187C (zh) | 1988-02-11 | 2000-09-06 | 金克克国际有限公司 | 新的蛋白水解酶及其在洗涤剂中的应用 |
| JP2728531B2 (ja) | 1988-03-24 | 1998-03-18 | ノボ ノルディスク アクティーゼルスカブ | セルラーゼ調製品 |
| US5648263A (en) | 1988-03-24 | 1997-07-15 | Novo Nordisk A/S | Methods for reducing the harshness of a cotton-containing fabric |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| DE3909096A1 (de) | 1989-03-20 | 1990-09-27 | Garabed Antranikian | Alpha-amylase |
| DK198089D0 (da) | 1989-04-24 | 1989-04-24 | Danske Spritfabrikker | Dna-materialer og anvendelse deraf |
| WO1991000353A2 (en) | 1989-06-29 | 1991-01-10 | Gist-Brocades N.V. | MUTANT MICROBIAL α-AMYLASES WITH INCREASED THERMAL, ACID AND/OR ALKALINE STABILITY |
| GB8915658D0 (en) | 1989-07-07 | 1989-08-23 | Unilever Plc | Enzymes,their production and use |
| KR100236540B1 (ko) | 1990-04-14 | 2000-01-15 | 레클로우크스 라우에르 | 알카리성 바실러스-리파제, 이를 코-딩하는 dna 서열 및 리파제를 생산하는 바실러스 균주 |
| DK0531372T4 (da) | 1990-05-09 | 2004-08-09 | Novozymes As | Cellulasepræparat omfattende et endoglucanaseenzym |
| US5814501A (en) | 1990-06-04 | 1998-09-29 | Genencor International, Inc. | Process for making dust-free enzyme-containing particles from an enzyme-containing fermentation broth |
| AU657278B2 (en) | 1990-09-13 | 1995-03-09 | Novo Nordisk A/S | Lipase variants |
| IL99552A0 (en) | 1990-09-28 | 1992-08-18 | Ixsys Inc | Compositions containing procaryotic cells,a kit for the preparation of vectors useful for the coexpression of two or more dna sequences and methods for the use thereof |
| WO1992006221A1 (en) | 1990-10-05 | 1992-04-16 | Genencor International, Inc. | Methods for treating cotton-containing fabrics with cellulase |
| US5180669A (en) | 1991-03-27 | 1993-01-19 | Genencor International, Inc. | Liquefaction of granular-starch slurries using alpha-amylase in the presence of carbonate ion |
| GB9108136D0 (en) | 1991-04-17 | 1991-06-05 | Unilever Plc | Concentrated detergent powder compositions |
| EP0511456A1 (en) | 1991-04-30 | 1992-11-04 | The Procter & Gamble Company | Liquid detergents with aromatic borate ester to inhibit proteolytic enzyme |
| CZ285148B6 (cs) | 1991-04-30 | 1999-05-12 | The Procter And Gamble Company | Kapalné detergentní směsi s borito-polyolovým komplexem k inhibici proteolytického enzymu |
| ES2121014T3 (es) | 1991-05-01 | 1998-11-16 | Novo Nordisk As | Enzimas estabilizadas y composiciones detergentes. |
| US5231017A (en) | 1991-05-17 | 1993-07-27 | Solvay Enzymes, Inc. | Process for producing ethanol |
| ATE189695T1 (de) | 1991-06-11 | 2000-02-15 | Genencor Int | Cellulasezusammensetzungen mit einem defizit an komponenten des typs-cbh i enthaltende reinigungsmittelzusammensetzungen |
| US5324649A (en) | 1991-10-07 | 1994-06-28 | Genencor International, Inc. | Enzyme-containing granules coated with hydrolyzed polyvinyl alcohol or copolymer thereof |
| DE69220807T2 (de) | 1991-10-31 | 1998-01-29 | Genencor Int | Verflüssigung einer trocken gemahlenen Aufschlämmung von Stärkekörnern. |
| DK72992D0 (da) | 1992-06-01 | 1992-06-01 | Novo Nordisk As | Enzym |
| DK88892D0 (da) | 1992-07-06 | 1992-07-06 | Novo Nordisk As | Forbindelse |
| WO1994002597A1 (en) | 1992-07-23 | 1994-02-03 | Novo Nordisk A/S | MUTANT α-AMYLASE, DETERGENT, DISH WASHING AGENT, AND LIQUEFACTION AGENT |
| PT867504E (pt) | 1993-02-11 | 2003-08-29 | Genencor Int | Alfa-amilase estavel a oxidacao |
| DK39093D0 (da) | 1993-04-01 | 1993-04-01 | Novo Nordisk As | Enzym |
| US5576281A (en) | 1993-04-05 | 1996-11-19 | Olin Corporation | Biogradable low foaming surfactants as a rinse aid for autodish applications |
| KR950702240A (ko) | 1993-04-27 | 1995-06-19 | 한스 발터 라벤 | 세제로의 이용을 위한 새로운 리파제 변형체 |
| DK52393D0 (https=) | 1993-05-05 | 1993-05-05 | Novo Nordisk As | |
| US5888954A (en) | 1993-05-08 | 1999-03-30 | Henkel Kommanditgesellschaft Auf Aktien | Corrosion inhibitors for silver |
| PL177936B1 (pl) | 1993-05-08 | 2000-01-31 | Henkel Kgaa | Niskoalkaliczny środek do maszynowego zmywania naczyń |
| CA2162459A1 (en) | 1993-05-08 | 1994-11-24 | Juergen Haerer | Corrosion inhibitors for silver (ii) |
| US5698504A (en) | 1993-07-01 | 1997-12-16 | The Procter & Gamble Company | Machine dishwashing composition containing oxygen bleach and paraffin oil and benzotriazole compound silver tarnishing inhibitors |
| JP2859520B2 (ja) | 1993-08-30 | 1999-02-17 | ノボ ノルディスク アクティーゼルスカブ | リパーゼ及びそれを生産する微生物及びリパーゼ製造方法及びリパーゼ含有洗剤組成物 |
| DE69434635D1 (en) | 1993-10-08 | 2006-04-27 | Novo Nordisk As | Amylasevarianten |
| CA2173329C (en) | 1993-10-08 | 2011-07-12 | Henrik Bisgard-Frantzen | Amylase variants |
| US5817495A (en) | 1993-10-13 | 1998-10-06 | Novo Nordisk A/S | H2 O2 -stable peroxidase variants |
| DE69434962T2 (de) | 1993-10-14 | 2008-01-17 | The Procter & Gamble Company, Cincinnati | Proteasehaltige reinigungsmittel |
| DK131193D0 (https=) | 1993-11-23 | 1993-11-23 | Novo Nordisk As | |
| DE4343591A1 (de) | 1993-12-21 | 1995-06-22 | Evotec Biosystems Gmbh | Verfahren zum evolutiven Design und Synthese funktionaler Polymere auf der Basis von Formenelementen und Formencodes |
| MY111537A (en) | 1994-02-02 | 2000-07-31 | Novo Nordisk As | A combined desizing and bleaching process. |
| US5605793A (en) | 1994-02-17 | 1997-02-25 | Affymax Technologies N.V. | Methods for in vitro recombination |
| DE69527835T2 (de) | 1994-02-22 | 2003-04-10 | Novozymes A/S, Bagsvaerd | Methode zur herstellung einer variante eines lipolytischen enzymes |
| US5824531A (en) | 1994-03-29 | 1998-10-20 | Novid Nordisk | Alkaline bacilus amylase |
| US5453216A (en) | 1994-04-28 | 1995-09-26 | Creative Products Resource, Inc. | Delayed-release encapsulated warewashing composition and process of use |
| WO1995030744A2 (en) | 1994-05-04 | 1995-11-16 | Genencor International Inc. | Lipases with improved surfactant resistance |
| FI964808A0 (fi) | 1994-06-03 | 1996-12-02 | Novo Nordisk Biotech Inc | Puhdistetut Myceliophthora lakkaasit ja niitä koodaavat nukleiinihapot |
| DK0772684T3 (da) | 1994-06-17 | 2005-12-12 | Genencor Int | Amylolytiske enzymer afledt fra B. Licheniformis alpha-amylasen med forbedrede karakteristika |
| WO1995035381A1 (en) | 1994-06-20 | 1995-12-28 | Unilever N.V. | Modified pseudomonas lipases and their use |
| AU2884695A (en) | 1994-06-23 | 1996-01-19 | Unilever Plc | Modified pseudomonas lipases and their use |
| CN101659926A (zh) | 1994-06-30 | 2010-03-03 | 诺沃奇梅兹有限公司 | 非毒性、非产毒性、非致病性镰孢属表达系统及所用启动子和终止子 |
| GB9413419D0 (en) | 1994-07-04 | 1994-08-24 | Danisco | Amylase enzyme |
| GB2291058B (en) | 1994-07-14 | 1998-12-23 | Solvay | Acid-stable and thermo-stable alpha-amylases derived from sufolobus species |
| PL318209A1 (en) | 1994-08-11 | 1997-05-26 | Genencor Int | Improved cleaning composition |
| BE1008998A3 (fr) | 1994-10-14 | 1996-10-01 | Solvay | Lipase, microorganisme la produisant, procede de preparation de cette lipase et utilisations de celle-ci. |
| US5827719A (en) | 1994-10-26 | 1998-10-27 | Novo Nordisk A/S | Enzyme with lipolytic activity |
| AR000862A1 (es) | 1995-02-03 | 1997-08-06 | Novozymes As | Variantes de una ó-amilasa madre, un metodo para producir la misma, una estructura de adn y un vector de expresion, una celula transformada por dichaestructura de adn y vector, un aditivo para detergente, composicion detergente, una composicion para lavado de ropa y una composicion para la eliminacion del |
| US6440716B1 (en) | 1995-02-03 | 2002-08-27 | Novozymes A/S | α-amylase mutants |
| CN101117629B (zh) * | 1995-02-03 | 2014-06-11 | 诺维信公司 | 淀粉酶变体 |
| KR100511499B1 (ko) | 1995-02-03 | 2005-12-21 | 노보자임스 에이/에스 | 소정 특성을 가지는 알파-아밀라제 돌연변이체를 디자인하는 방법 |
| US7115409B1 (en) | 1995-02-03 | 2006-10-03 | Novozymes A/S | α-amylase mutants |
| US6093562A (en) * | 1996-02-05 | 2000-07-25 | Novo Nordisk A/S | Amylase variants |
| JPH08228778A (ja) | 1995-02-27 | 1996-09-10 | Showa Denko Kk | 新規なリパーゼ遺伝子及びそれを用いたリパーゼの製造方法 |
| KR19980702782A (ko) | 1995-03-09 | 1998-08-05 | 혼 마가렛 에이. | 녹말 액화 방법 |
| EP0815193A1 (en) | 1995-03-24 | 1998-01-07 | Genencor International Inc. | An improved laundry detergent composition comprising amylase |
| US5652127A (en) | 1995-06-02 | 1997-07-29 | Genencor International, Inc. | Method for liquefying starch |
| US5736499A (en) | 1995-06-06 | 1998-04-07 | Genencor International, Inc. | Mutant A-amylase |
| JP3025627B2 (ja) | 1995-06-14 | 2000-03-27 | 花王株式会社 | 液化型アルカリα−アミラーゼ遺伝子 |
| EP0839186B1 (en) | 1995-07-14 | 2004-11-10 | Novozymes A/S | A modified enzyme with lipolytic activity |
| AU6655196A (en) | 1995-08-11 | 1997-03-12 | Novo Nordisk A/S | Novel lipolytic enzymes |
| ES2432519T3 (es) | 1996-04-30 | 2013-12-04 | Novozymes A/S | Mutantes de alfa-amilasa |
| US5763385A (en) | 1996-05-14 | 1998-06-09 | Genencor International, Inc. | Modified α-amylases having altered calcium binding properties |
| US6211134B1 (en) | 1996-05-14 | 2001-04-03 | Genecor International, Inc. | Mutant α-amylase |
| CN1229428A (zh) | 1996-08-01 | 1999-09-22 | 普罗格特-甘布尔公司 | 用于清洗污秽织物的包含改进的淀粉酶的洗涤剂组合物 |
| WO1998015257A1 (en) | 1996-10-08 | 1998-04-16 | Novo Nordisk A/S | Diaminobenzoic acid derivatives as dye precursors |
| JP4044143B2 (ja) | 1996-11-04 | 2008-02-06 | ノボザイムス アクティーゼルスカブ | ズブチラーゼ変異体及び組成物 |
| EP0932667B1 (en) | 1996-11-04 | 2008-10-01 | Novozymes A/S | Subtilase variants and compositions |
| CN1246146A (zh) | 1996-11-26 | 2000-03-01 | 金克克国际有限公司 | 化学修饰的酶 |
| WO1998034946A1 (en) | 1997-02-12 | 1998-08-13 | Massachusetts Institute Of Technology | Daxx, a novel fas-binding protein that activates jnk and apoptosis |
| AU8564598A (en) | 1997-08-01 | 1999-02-22 | Marine Shuttle Operations As | Method and transporter for installation or removal of an offshore platform topsides |
| GB2327947A (en) | 1997-08-02 | 1999-02-10 | Procter & Gamble | Detergent tablet |
| US6599871B2 (en) | 1997-08-02 | 2003-07-29 | The Procter & Gamble Company | Detergent tablet |
| US6080568A (en) | 1997-08-19 | 2000-06-27 | Genencor International, Inc. | Mutant α-amylase comprising modification at residues corresponding to A210, H405 and/or T412 in Bacillus licheniformis |
| US6361989B1 (en) | 1997-10-13 | 2002-03-26 | Novozymes A/S | α-amylase and α-amylase variants |
| US6187576B1 (en) | 1997-10-13 | 2001-02-13 | Novo Nordisk A/S | α-amylase mutants |
| AR015977A1 (es) | 1997-10-23 | 2001-05-30 | Genencor Int | Variantes de proteasa multiplemente substituida con carga neta alterada para su empleo en detergentes |
| US6204232B1 (en) * | 1997-10-30 | 2001-03-20 | Novo Nordisk A/S | α-amlase mutants |
| US6562612B2 (en) | 1997-11-19 | 2003-05-13 | Genencor International, Inc. | Cellulase producing actinomycetes, cellulase produced therefrom and method of producing same |
| US6773907B2 (en) | 1997-11-21 | 2004-08-10 | Peter Kamp Hansen | Subtilase enzymes |
| CN1261567C (zh) | 1997-11-26 | 2006-06-28 | 诺维信公司 | 热稳定的葡糖淀粉酶 |
| AU2411699A (en) | 1998-02-18 | 1999-09-06 | Novo Nordisk A/S | Alkaline bacillus amylase |
| CA2323581A1 (en) | 1998-04-01 | 1999-10-07 | Dsm N.V. | Application of phytase in feed having low content of phytate |
| MXPA01000352A (es) | 1998-07-15 | 2002-06-04 | Novozymes As | Varientes de glucoamilasa. |
| CN1197965C (zh) | 1998-10-26 | 2005-04-20 | 诺维信公司 | 在丝状真菌细胞内构建和筛选目的dna文库 |
| US6197565B1 (en) | 1998-11-16 | 2001-03-06 | Novo-Nordisk A/S | α-Amylase variants |
| US6403355B1 (en) | 1998-12-21 | 2002-06-11 | Kao Corporation | Amylases |
| CN100510096C (zh) | 1999-03-22 | 2009-07-08 | 诺沃奇梅兹有限公司 | 用于在真菌细胞中表达基因的启动子 |
| US6410295B1 (en) | 1999-03-30 | 2002-06-25 | Novozymes A/S | Alpha-amylase variants |
| WO2000060059A2 (en) | 1999-03-30 | 2000-10-12 | NovozymesA/S | Alpha-amylase variants |
| US6623948B1 (en) | 1999-03-31 | 2003-09-23 | Novozymes A/S | Nucleic acid sequences encoding alkaline alpha-amylases |
| JP4745503B2 (ja) | 1999-03-31 | 2011-08-10 | ノボザイムス アクティーゼルスカブ | アルカリα−アミラーゼ活性を有するポリペプチド及びそれらをコードする核酸 |
| ATE422538T1 (de) | 1999-03-31 | 2009-02-15 | Novozymes As | Polypeptide mit alkaliner alpha-amylase-aktivität und für diese kodierende nukleinsäuren |
| CN100510067C (zh) | 1999-07-09 | 2009-07-08 | 诺维信公司 | 葡糖淀粉酶变体 |
| DK1210413T3 (da) | 1999-08-13 | 2010-04-12 | Univ Manchester | Phytaseenzymer, nukleinsyrer, der koder for phytaseenzymer, og vektorer og værtsceller indeholdende de samme |
| JP4741128B2 (ja) | 1999-08-20 | 2011-08-03 | ノボザイムス アクティーゼルスカブ | アルカリバチルスアミラーゼ |
| US6995125B2 (en) | 2000-02-17 | 2006-02-07 | The Procter & Gamble Company | Detergent product |
| AU3724801A (en) | 2000-03-03 | 2001-09-12 | Novozymes A/S | Polypeptides having alkaline alpha-amylase activity and nucleic acids encoding same |
| JP5571274B2 (ja) * | 2000-03-08 | 2014-08-13 | ノボザイムス アクティーゼルスカブ | 改変された特性を有する変異体 |
| MXPA03000488A (es) | 2000-07-19 | 2003-06-24 | Procter & Gamble | Composiciones para el lavado automatico de trastes en forma de gel, metodos de preparacion y uso de las mismas. |
| GB2365018A (en) | 2000-07-24 | 2002-02-13 | Procter & Gamble | Water soluble pouches |
| CN100491525C (zh) | 2000-07-28 | 2009-05-27 | 汉高两合股份公司 | 从芽孢杆菌a7-7(dsm 12368)中提取的新型淀粉分解酶以及含有该新型淀粉分解酶的洗涤剂和清洗剂 |
| US20020155574A1 (en) * | 2000-08-01 | 2002-10-24 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| EP2308980A3 (en) * | 2000-08-01 | 2011-04-27 | Novozymes A/S | Alpha-amylase mutants with altered properties |
| WO2002014490A2 (en) | 2000-08-11 | 2002-02-21 | Genencor International, Inc. | Bacillus transformation, transformants and mutant libraries |
| JP4426716B2 (ja) | 2000-10-11 | 2010-03-03 | 花王株式会社 | 高生産性α−アミラーゼ |
| EP1326965A2 (en) | 2000-10-13 | 2003-07-16 | Novozymes A/S | Alpha-amylase variant with altered properties |
| ES2431044T5 (es) | 2000-11-27 | 2022-05-27 | Procter & Gamble | Método de lavado de vajillas |
| AU2002223020B2 (en) | 2000-11-27 | 2006-07-06 | Novozymes A/S | Automated mechanical stress assay for screening cleaning ingredients |
| PL362604A1 (en) | 2000-11-27 | 2004-11-02 | The Procter & Gamble Company | Dishwashing method |
| US7125828B2 (en) | 2000-11-27 | 2006-10-24 | The Procter & Gamble Company | Detergent products, methods and manufacture |
| US20020169091A1 (en) | 2001-02-14 | 2002-11-14 | Clare Jonathan Richard | Automatic dishwashing compositions comprising blooming perfume and base masking ingredients |
| US20020183226A1 (en) | 2001-02-28 | 2002-12-05 | Chandrika Kasturi | Liquid detergent composition exhibiting enhanced alpha-amylase enzyme stability |
| ATE449840T1 (de) | 2001-05-15 | 2009-12-15 | Novozymes As | Alpha-amylasevariante mit veränderten eigenschaften |
| GB0114847D0 (en) | 2001-06-18 | 2001-08-08 | Unilever Plc | Water soluble package and liquid contents thereof |
| WO2003012036A2 (en) | 2001-07-27 | 2003-02-13 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Systems for in vivo site-directed mutagenesis using oligonucleotides |
| EP1444318B1 (en) | 2001-11-14 | 2009-07-01 | The Procter & Gamble Company | Automatic dishwashing composition in unit dose form comprising an anti-scaling polymer |
| US7888093B2 (en) | 2002-11-06 | 2011-02-15 | Novozymes A/S | Subtilase variants |
| WO2004074419A2 (en) | 2003-02-18 | 2004-09-02 | Novozymes A/S | Detergent compositions |
| ATE387487T1 (de) | 2003-05-23 | 2008-03-15 | Procter & Gamble | Waschmittelzusammensetzung zum gebrauch in einer textilwasch- oder geschirrspülmaschine |
| US8535927B1 (en) | 2003-11-19 | 2013-09-17 | Danisco Us Inc. | Micrococcineae serine protease polypeptides and compositions thereof |
| US7985569B2 (en) | 2003-11-19 | 2011-07-26 | Danisco Us Inc. | Cellulomonas 69B4 serine protease variants |
| DE102004020082A1 (de) | 2004-04-24 | 2005-05-19 | Henkel Kgaa | Verfahren zur Herstellung von Wasch- und/oder Reinigungsmitteln |
| GB2414958A (en) | 2004-06-11 | 2005-12-14 | Reckitt Benckiser Nv | A process for preparing a water soluble article. |
| ES2554635T3 (es) | 2004-07-05 | 2015-12-22 | Novozymes A/S | Variantes de alfa-amilasa con propiedades alteradas |
| DE102004047776B4 (de) | 2004-10-01 | 2018-05-09 | Basf Se | Gegen Di- und/oder Multimerisierung stabilisierte Alpha-Amylase-Varianten, Verfahren zu deren Herstellung sowie deren Verwendung |
| DE102004047777B4 (de) * | 2004-10-01 | 2018-05-09 | Basf Se | Alpha-Amylase-Varianten mit erhöhter Lösungsmittelstabilität, Verfahren zu deren Herstellung sowie deren Verwendung |
| GB0423139D0 (en) | 2004-10-18 | 2004-11-17 | Danisco | Enzymes |
| CN101068922B (zh) | 2004-11-30 | 2015-06-03 | 金克克国际有限公司 | 里氏木霉葡糖淀粉酶及其同源物 |
| ATE481444T1 (de) | 2005-05-13 | 2010-10-15 | Procter & Gamble | Funktionalisierte folien |
| US7562841B2 (en) | 2005-07-15 | 2009-07-21 | Sonoco Development, Inc. | Textile carrier having identification feature and method for manufacturing the same |
| US20080293610A1 (en) | 2005-10-12 | 2008-11-27 | Andrew Shaw | Use and production of storage-stable neutral metalloprotease |
| US20070191248A1 (en) | 2006-01-23 | 2007-08-16 | Souter Philip F | Detergent compositions |
| CA2633798A1 (en) | 2006-01-23 | 2007-08-02 | The Procter & Gamble Company | Detergent compositions |
| EP1979475A2 (en) | 2006-01-23 | 2008-10-15 | The Procter and Gamble Company | Detergent compositions |
| US20070184855A1 (en) | 2006-02-03 | 2007-08-09 | Research In Motion Limited | Visual representation of contact location |
| US8071345B2 (en) | 2006-03-31 | 2011-12-06 | Novozymes A/S | Stabilized subtilisin composition |
| DE102006022224A1 (de) | 2006-05-11 | 2007-11-15 | Henkel Kgaa | Subtilisin aus Bacillus pumilus und Wasch- und Reinigungsmittel enthaltend dieses neue Subtilisin |
| DE102006022216A1 (de) | 2006-05-11 | 2007-11-15 | Henkel Kgaa | Neue Alkalische Protease aus Bacillus gibsonii und Wasch- und Reinigungsmittel enthaltend diese neue Alkalische Protease |
| WO2007145964A2 (en) | 2006-06-05 | 2007-12-21 | The Procter & Gamble Company | Enzyme stabilizer |
| CN101473036B (zh) | 2006-06-23 | 2012-12-12 | 丹尼斯科美国公司 | 利用用于工程改造多种性质的位点评价文库对序列和活性关系进行系统评价 |
| KR20090031906A (ko) | 2006-07-18 | 2009-03-30 | 다니스코 유에스 인크. | 광범위한 온도에 걸쳐 활성인 프로테아제 변이형 |
| US20080220498A1 (en) | 2007-03-06 | 2008-09-11 | Cervin Marguerite A | Variant Buttiauxella sp. phytases having altered properties |
| CA2690055A1 (en) | 2007-06-06 | 2008-12-18 | Danisco Us Inc. | Methods for improving protein performance |
| GB0718944D0 (en) | 2007-09-28 | 2007-11-07 | Reckitt Benckiser Nv | Detergent composition |
| BRPI0820503A2 (pt) | 2007-11-05 | 2015-06-16 | Danisco Us Inc | Variantes da alfa amilase de bacillus licheniformis com termoestabilidade aumentada e/ou dependência de cálcio diminuída |
| US8206966B2 (en) | 2007-11-05 | 2012-06-26 | Danisco Us Inc. | Alpha-amylase variants with altered properties |
| EP2085070A1 (en) * | 2008-01-11 | 2009-08-05 | Procter & Gamble International Operations SA. | Cleaning and/or treatment compositions |
| US20090209447A1 (en) | 2008-02-15 | 2009-08-20 | Michelle Meek | Cleaning compositions |
| EP2100948A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| EP2100947A1 (en) | 2008-03-14 | 2009-09-16 | The Procter and Gamble Company | Automatic dishwashing detergent composition |
| US20090233830A1 (en) | 2008-03-14 | 2009-09-17 | Penny Sue Dirr | Automatic detergent dishwashing composition |
| MX2010013113A (es) | 2008-06-06 | 2010-12-21 | Danisco Inc | Variantes de alfa-amilasa geobacillus stearothermophilus con propiedades mejoradas. |
| EP2414515A2 (en) * | 2009-04-01 | 2012-02-08 | Danisco US Inc. | Cleaning system comprising an alpha-amylase and a protease |
| EP3404087A1 (en) | 2010-02-10 | 2018-11-21 | Novozymes A/S | Alpha-amylase variants with high stability in presence of a chelating agent |
| EP2357220A1 (en) * | 2010-02-10 | 2011-08-17 | The Procter & Gamble Company | Cleaning composition comprising amylase variants with high stability in the presence of a chelating agent |
| EP2540824A1 (en) | 2011-06-30 | 2013-01-02 | The Procter & Gamble Company | Cleaning compositions comprising amylase variants reference to a sequence listing |
| US9434932B2 (en) | 2011-06-30 | 2016-09-06 | Novozymes A/S | Alpha-amylase variants |
| BR122020009747B1 (pt) | 2011-06-30 | 2021-07-20 | Novozymes A/S | Polipeptídeo e alfa-amilase variantes, composição detergente, e, utilização de uma alfa- amilase variante |
| EP3301145A1 (en) * | 2016-10-03 | 2018-04-04 | The Procter & Gamble Company | Low ph laundry detergent composition |
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