ES2404304T3 - Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores - Google Patents

Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores Download PDF

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Publication number
ES2404304T3
ES2404304T3 ES04793896T ES04793896T ES2404304T3 ES 2404304 T3 ES2404304 T3 ES 2404304T3 ES 04793896 T ES04793896 T ES 04793896T ES 04793896 T ES04793896 T ES 04793896T ES 2404304 T3 ES2404304 T3 ES 2404304T3
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Spain
Prior art keywords
maitansinoid
conjugate
antibody
smcc
cleavable
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ES04793896T
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English (en)
Spanish (es)
Inventor
Rita Steeves
Robert Lutz
Ravi Chari
Hongsheng Xie
Yelena Kovtun
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Immunogen Inc
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Immunogen Inc
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • C07K16/3092—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties against tumour-associated mucins
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ES04793896T 2003-10-10 2004-10-12 Conjugados de maitansinoide DM1 con anticuerpo trastuzumab, unidos mediante un conector no escindible, y su uso en el tratamiento de tumores Active ES2404304T3 (es)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US50990103P 2003-10-10 2003-10-10
US509901P 2003-10-10
US960602 2004-10-08
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