ES2125259T3 - Dispositivos de distribucion de farmacos de liberacion sostenida. - Google Patents

Dispositivos de distribucion de farmacos de liberacion sostenida.

Info

Publication number
ES2125259T3
ES2125259T3 ES92906830T ES92906830T ES2125259T3 ES 2125259 T3 ES2125259 T3 ES 2125259T3 ES 92906830 T ES92906830 T ES 92906830T ES 92906830 T ES92906830 T ES 92906830T ES 2125259 T3 ES2125259 T3 ES 2125259T3
Authority
ES
Spain
Prior art keywords
coating layer
effective agent
inner core
pharmaces
distribution devices
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
ES92906830T
Other languages
English (en)
Inventor
Thomas J Smith
Paul Ashton
Paul A Pearson
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
University of Kentucky Research Foundation
Original Assignee
University of Kentucky Research Foundation
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by University of Kentucky Research Foundation filed Critical University of Kentucky Research Foundation
Application granted granted Critical
Publication of ES2125259T3 publication Critical patent/ES2125259T3/es
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61F—FILTERS IMPLANTABLE INTO BLOOD VESSELS; PROSTHESES; DEVICES PROVIDING PATENCY TO, OR PREVENTING COLLAPSING OF, TUBULAR STRUCTURES OF THE BODY, e.g. STENTS; ORTHOPAEDIC, NURSING OR CONTRACEPTIVE DEVICES; FOMENTATION; TREATMENT OR PROTECTION OF EYES OR EARS; BANDAGES, DRESSINGS OR ABSORBENT PADS; FIRST-AID KITS
    • A61F9/00—Methods or devices for treatment of the eyes; Devices for putting-in contact lenses; Devices to correct squinting; Apparatus to guide the blind; Protective devices for the eyes, carried on the body or in the hand
    • A61F9/0008—Introducing ophthalmic products into the ocular cavity or retaining products therein
    • A61F9/0017—Introducing ophthalmic products into the ocular cavity or retaining products therein implantable in, or in contact with, the eye, e.g. ocular inserts
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0048—Eye, e.g. artificial tears
    • A61K9/0051—Ocular inserts, ocular implants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5073—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals having two or more different coatings optionally including drug-containing subcoatings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
    • A61P27/02—Ophthalmic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/20—Pills, tablets, discs, rods
    • A61K9/28—Dragees; Coated pills or tablets, e.g. with film or compression coating
    • A61K9/2806—Coating materials
    • A61K9/2833—Organic macromolecular compounds
    • A61K9/284—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/5005—Wall or coating material
    • A61K9/5021—Organic macromolecular compounds
    • A61K9/5026—Organic macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. polyvinyl pyrrolidone, poly(meth)acrylates

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Ophthalmology & Optometry (AREA)
  • Epidemiology (AREA)
  • Biomedical Technology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Organic Chemistry (AREA)
  • Vascular Medicine (AREA)
  • Heart & Thoracic Surgery (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Communicable Diseases (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Infusion, Injection, And Reservoir Apparatuses (AREA)

Abstract

SE PRESENTA UN METODO Y DISPOSITIVO PARA TRATAR UN ORGANISMO DE MAMIFERO PARA OBTENER UN EFECTO FISIOLOGICO SISTEMICO O LOCAL O FARMACOLOGICO. EL METODO CONSISTE EN LA ADMINISTRACION DE UN SISTEMA DISPENSADOR DE MEDICINA DE LIBERACION SOSTENIDA A UN ORGANISMO DE MAMIFERO QUE NECESITA TAL TRATAMIENTO EN UN AREA EN LA QUE SE DESEA LA LIBERACION DE UN AGENTE EFECTIVO Y QUE PERMITE QUE EL AGENTE EFECTIVO PASE A TRAVES DEL DISPOSITIVO DE UNA MANERA CONTROLADA. EL DISPOSITIVO (1) COMPRENDE UN NUCLEO O DEPOSITO (5) QUE COMPRENDE EL AGENTE EFECTIVO; UNA PRIMERA CAPA DE REVESTIMIENTO (10), QUE ES ESENCIALMENTE IMPERMEABLE AL PASO DEL AGENTE EFECTIVO; Y UNA SEGUNDA CAPA DE REVESTIMIENTO (15) QUE ES PERMEABLE AL PASO DEL AGENTE EFECTIVO. LA PRIMERA CAPA DE REVESTIMIENTO CUBRE AL MENOS UNA PARTE DEL NUCLEO INTERNO; AUNQUE AL MENOS UNA PEQUEÑA PARTE DEL NUCLEO INTERNO NO ESTA REVESTIDA CON LA PRIMERA CAPA DE REVESTIMIENTO. LA SEGUNDA CAPA DE REVESTIMIENTO CUBRE ESENCIALMENTE EN SU TOTALIDAD LA PRIMERA CAPA DE REVESTIMIENTO Y LA PARTE NO REVESTIDA DEL NUCLEO INTERNO.
ES92906830T 1991-02-21 1992-02-21 Dispositivos de distribucion de farmacos de liberacion sostenida. Expired - Lifetime ES2125259T3 (es)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US07/658,695 US5378475A (en) 1991-02-21 1991-02-21 Sustained release drug delivery devices

Publications (1)

Publication Number Publication Date
ES2125259T3 true ES2125259T3 (es) 1999-03-01

Family

ID=24642282

Family Applications (2)

Application Number Title Priority Date Filing Date
ES92906830T Expired - Lifetime ES2125259T3 (es) 1991-02-21 1992-02-21 Dispositivos de distribucion de farmacos de liberacion sostenida.
ES98104053T Expired - Lifetime ES2366573T3 (es) 1991-02-21 1992-02-21 Dispositivos de suministro de fármacos de liberación prolongada.

Family Applications After (1)

Application Number Title Priority Date Filing Date
ES98104053T Expired - Lifetime ES2366573T3 (es) 1991-02-21 1992-02-21 Dispositivos de suministro de fármacos de liberación prolongada.

Country Status (10)

Country Link
US (1) US5378475A (es)
EP (2) EP0861659B1 (es)
JP (2) JPH06505274A (es)
AT (2) ATE511832T1 (es)
AU (1) AU660012B2 (es)
CA (1) CA2104699C (es)
DE (1) DE69227187T2 (es)
DK (2) DK0861659T3 (es)
ES (2) ES2125259T3 (es)
WO (1) WO1992014450A1 (es)

Families Citing this family (438)

* Cited by examiner, † Cited by third party
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EP0577646A1 (en) 1994-01-12
EP0861659A1 (en) 1998-09-02
EP0577646A4 (en) 1994-06-01
US5378475A (en) 1995-01-03
ATE171617T1 (de) 1998-10-15
DK0861659T3 (da) 2011-08-29
JP2003002825A (ja) 2003-01-08
DE69227187T2 (de) 1999-06-02
JPH06505274A (ja) 1994-06-16
ES2366573T3 (es) 2011-10-21
WO1992014450A1 (en) 1992-09-03
CA2104699A1 (en) 1992-08-22
CA2104699C (en) 2008-02-12
DE69227187D1 (de) 1998-11-05
JP3908592B2 (ja) 2007-04-25
AU660012B2 (en) 1995-06-08
DK0577646T3 (da) 1999-06-21
AU1419792A (en) 1992-09-15
EP0577646B1 (en) 1998-09-30
EP0861659B1 (en) 2011-06-08
ATE511832T1 (de) 2011-06-15

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