EA200800908A1 - Получение прегабалина и родственных соединений - Google Patents

Получение прегабалина и родственных соединений

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Publication number
EA200800908A1
EA200800908A1 EA200800908A EA200800908A EA200800908A1 EA 200800908 A1 EA200800908 A1 EA 200800908A1 EA 200800908 A EA200800908 A EA 200800908A EA 200800908 A EA200800908 A EA 200800908A EA 200800908 A1 EA200800908 A1 EA 200800908A1
Authority
EA
Eurasian Patent Office
Prior art keywords
related compounds
pregabalin
obtaining
obtaining pregabalin
aminomethyl
Prior art date
Application number
EA200800908A
Other languages
English (en)
Other versions
EA015418B1 (ru
Inventor
Шангхуи Ху
Карлос Альберто Мартинес
Йунхуа Тао
Уилльям Юджин Талли
Патрик Жерар Томас Келлехер
Ив Рене Дюмон
Original Assignee
УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
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First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35295367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=EA200800908(A1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си filed Critical УОРНЕР-ЛАМБЕРТ КОМПАНИ Эл-Эл-Си
Publication of EA200800908A1 publication Critical patent/EA200800908A1/ru
Publication of EA015418B1 publication Critical patent/EA015418B1/ru

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Abstract

Раскрыты способы получения энантиомерно обогащенных γ-аминокислот формулы 1, в том числе (S)-(+)-3-аминометил-5-метилгексановой кислоты (прегабалина), посредством ферментативного кинетического разделения.
EA200800908A 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений EA015418B1 (ru)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US58167104P 2004-06-21 2004-06-21
US62903404P 2004-11-18 2004-11-18

Publications (2)

Publication Number Publication Date
EA200800908A1 true EA200800908A1 (ru) 2008-12-30
EA015418B1 EA015418B1 (ru) 2011-08-30

Family

ID=35295367

Family Applications (3)

Application Number Title Priority Date Filing Date
EA200800908A EA015418B1 (ru) 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений
EA200800909A EA200800909A1 (ru) 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений
EA200602099A EA011765B1 (ru) 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений

Family Applications After (2)

Application Number Title Priority Date Filing Date
EA200800909A EA200800909A1 (ru) 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений
EA200602099A EA011765B1 (ru) 2004-06-21 2005-06-09 Получение прегабалина и родственных соединений

Country Status (33)

Country Link
US (4) US20050283023A1 (ru)
EP (1) EP1831154B1 (ru)
JP (5) JP4174551B2 (ru)
KR (3) KR100847928B1 (ru)
CN (2) CN1972904B (ru)
AP (1) AP2466A (ru)
AR (1) AR049446A1 (ru)
AT (1) ATE455093T1 (ru)
AU (1) AU2005256945B2 (ru)
BR (1) BRPI0512347B8 (ru)
CA (1) CA2571040C (ru)
CR (2) CR8765A (ru)
CY (1) CY1110337T1 (ru)
DE (1) DE602005018965D1 (ru)
DK (1) DK1831154T3 (ru)
EA (3) EA015418B1 (ru)
ES (1) ES2336014T3 (ru)
GE (1) GEP20104895B (ru)
HK (2) HK1104024A1 (ru)
HR (1) HRP20100054T1 (ru)
IL (1) IL179614A0 (ru)
MA (1) MA28674B1 (ru)
ME (1) ME01067B (ru)
MX (1) MXPA06014228A (ru)
NO (1) NO338097B1 (ru)
NZ (1) NZ552220A (ru)
PL (1) PL1831154T3 (ru)
PT (1) PT1831154E (ru)
RS (1) RS51210B (ru)
SI (1) SI1831154T1 (ru)
TW (6) TWI377191B (ru)
UA (1) UA83575C2 (ru)
WO (1) WO2006000904A2 (ru)

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CN104557576B (zh) * 2014-12-19 2019-07-19 浙江华海药业股份有限公司 一种高纯度普瑞巴林的制备方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN107445864B (zh) * 2017-08-09 2020-01-17 无锡殷达尼龙有限公司 一种纯化长碳链氰基酸产物的方法
CN108358799B (zh) * 2018-04-24 2020-11-10 贵州师范大学 一种普瑞巴林的制备方法
CN109503403B (zh) * 2018-12-21 2021-11-16 卓和药业集团股份有限公司 一种普瑞巴林的拆分方法
CN113248416B (zh) * 2020-02-10 2024-03-26 江西博腾药业有限公司 1-((苄氧基)羰基)-4-乙基吡咯烷-3-羧酸的制备方法及其应用
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Also Published As

Publication number Publication date
TWI399361B (zh) 2013-06-21
JP4800346B2 (ja) 2011-10-26
KR20080015524A (ko) 2008-02-19
TW200846307A (en) 2008-12-01
MA28674B1 (fr) 2007-06-01
TWI396743B (zh) 2013-05-21
CR20110483A (es) 2011-10-24
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