CY1110337T1 - Παρασκευη πρεγκαμπαλινης και σχετικων ενωσεων - Google Patents

Παρασκευη πρεγκαμπαλινης και σχετικων ενωσεων

Info

Publication number
CY1110337T1
CY1110337T1 CY20101100272T CY101100272T CY1110337T1 CY 1110337 T1 CY1110337 T1 CY 1110337T1 CY 20101100272 T CY20101100272 T CY 20101100272T CY 101100272 T CY101100272 T CY 101100272T CY 1110337 T1 CY1110337 T1 CY 1110337T1
Authority
CY
Cyprus
Prior art keywords
preparation
pregampalin
unions
aminomethyl
methyl
Prior art date
Application number
CY20101100272T
Other languages
English (en)
Inventor
Shangui Hu
Carlos A Martinez
Junhua Tao
William E Tully
Patrick Gt Kelleher
Yves R Dumond
Original Assignee
Warner-Lambert Company Llc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=35295367&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=CY1110337(T1) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Warner-Lambert Company Llc filed Critical Warner-Lambert Company Llc
Publication of CY1110337T1 publication Critical patent/CY1110337T1/el

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/12—Formation of amino and carboxyl groups
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C253/00—Preparation of carboxylic acid nitriles
    • C07C253/30—Preparation of carboxylic acid nitriles by reactions not involving the formation of cyano groups
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/02—Amides, e.g. chloramphenicol or polyamides; Imides or polyimides; Urethanes, i.e. compounds comprising N-C=O structural element or polyurethanes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/08—Antiepileptics; Anticonvulsants
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/04—Formation of amino groups in compounds containing carboxyl groups
    • C07C227/06—Formation of amino groups in compounds containing carboxyl groups by addition or substitution reactions, without increasing the number of carbon atoms in the carbon skeleton of the acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
    • C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
    • C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C227/22—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from lactams, cyclic ketones or cyclic oximes, e.g. by reactions involving Beckmann rearrangement
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C229/00—Compounds containing amino and carboxyl groups bound to the same carbon skeleton
    • C07C229/02—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton
    • C07C229/04—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated
    • C07C229/24—Compounds containing amino and carboxyl groups bound to the same carbon skeleton having amino and carboxyl groups bound to acyclic carbon atoms of the same carbon skeleton the carbon skeleton being acyclic and saturated having more than one carboxyl group bound to the carbon skeleton, e.g. aspartic acid
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C255/00—Carboxylic acid nitriles
    • C07C255/01—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms
    • C07C255/19—Carboxylic acid nitriles having cyano groups bound to acyclic carbon atoms containing cyano groups and carboxyl groups, other than cyano groups, bound to the same saturated acyclic carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/18—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member
    • C07D207/22—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having one double bond between ring members or between a ring member and a non-ring member with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/24—Oxygen or sulfur atoms
    • C07D207/26—2-Pyrrolidones
    • C07D207/273—2-Pyrrolidones with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to other ring carbon atoms
    • C07D207/277—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/001—Amines; Imines
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P13/00—Preparation of nitrogen-containing organic compounds
    • C12P13/002—Nitriles (-CN)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12P—FERMENTATION OR ENZYME-USING PROCESSES TO SYNTHESISE A DESIRED CHEMICAL COMPOUND OR COMPOSITION OR TO SEPARATE OPTICAL ISOMERS FROM A RACEMIC MIXTURE
    • C12P7/00—Preparation of oxygen-containing organic compounds
    • C12P7/40—Preparation of oxygen-containing organic compounds containing a carboxyl group including Peroxycarboxylic acids
    • C12P7/42—Hydroxy-carboxylic acids

Abstract

Αποκαλύπτονται υλικά και μέθοδοι για παρασκεύη (S)-(+)-3-αμινομεθυλ-5-μεθυλ-εξανοϊκού οξέος και συντακτικώς συναφών ενώσεων μέσων ενζυματικού κινητικού διαχωρισμού.
CY20101100272T 2004-06-21 2010-03-22 Παρασκευη πρεγκαμπαλινης και σχετικων ενωσεων CY1110337T1 (el)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US58167104P 2004-06-21 2004-06-21
US62903404P 2004-11-18 2004-11-18
EP05753107A EP1831154B1 (en) 2004-06-21 2005-06-09 Preparation of pregabalin and related compounds

Publications (1)

Publication Number Publication Date
CY1110337T1 true CY1110337T1 (el) 2015-01-14

Family

ID=35295367

Family Applications (1)

Application Number Title Priority Date Filing Date
CY20101100272T CY1110337T1 (el) 2004-06-21 2010-03-22 Παρασκευη πρεγκαμπαλινης και σχετικων ενωσεων

Country Status (33)

Country Link
US (4) US20050283023A1 (el)
EP (1) EP1831154B1 (el)
JP (5) JP4174551B2 (el)
KR (3) KR100847928B1 (el)
CN (2) CN102102114B (el)
AP (1) AP2466A (el)
AR (1) AR049446A1 (el)
AT (1) ATE455093T1 (el)
AU (1) AU2005256945B2 (el)
BR (1) BRPI0512347B8 (el)
CA (1) CA2571040C (el)
CR (2) CR8765A (el)
CY (1) CY1110337T1 (el)
DE (1) DE602005018965D1 (el)
DK (1) DK1831154T3 (el)
EA (3) EA200800909A1 (el)
ES (1) ES2336014T3 (el)
GE (1) GEP20104895B (el)
HK (2) HK1104024A1 (el)
HR (1) HRP20100054T1 (el)
IL (1) IL179614A0 (el)
MA (1) MA28674B1 (el)
ME (1) ME01067B (el)
MX (1) MXPA06014228A (el)
NO (1) NO338097B1 (el)
NZ (1) NZ552220A (el)
PL (1) PL1831154T3 (el)
PT (1) PT1831154E (el)
RS (1) RS51210B (el)
SI (1) SI1831154T1 (el)
TW (6) TWI377191B (el)
UA (1) UA83575C2 (el)
WO (1) WO2006000904A2 (el)

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WO2006122255A1 (en) 2005-05-10 2006-11-16 Teva Pharmaceutical Industries Ltd. Pregabalin free of isobutylglutaric acid and a process for preparation thereof
EP1879854B1 (en) 2005-05-10 2011-09-07 Teva Pharmaceutical Industries Ltd Optical resolution of 3-carbamoylmethyl-5-methyl hexanoic acid
EP1879851B1 (en) 2005-05-10 2010-11-03 Teva Pharmaceutical Industries Ltd Method for the preparation of pregabalin and salts thereof
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CN102952057B (zh) * 2012-11-07 2015-09-09 浙江普洛家园药业有限公司 一种4-异丁基吡咯烷-2-酮的制备方法
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CN104557576B (zh) * 2014-12-19 2019-07-19 浙江华海药业股份有限公司 一种高纯度普瑞巴林的制备方法
CN105348125A (zh) * 2015-11-26 2016-02-24 太仓运通生物化工有限公司 一种以异戊醛为原料合成普瑞巴林的方法
CN107445864B (zh) * 2017-08-09 2020-01-17 无锡殷达尼龙有限公司 一种纯化长碳链氰基酸产物的方法
CN108358799B (zh) * 2018-04-24 2020-11-10 贵州师范大学 一种普瑞巴林的制备方法
CN109503403B (zh) * 2018-12-21 2021-11-16 卓和药业集团股份有限公司 一种普瑞巴林的拆分方法
CN113248416B (zh) * 2020-02-10 2024-03-26 江西博腾药业有限公司 1-((苄氧基)羰基)-4-乙基吡咯烷-3-羧酸的制备方法及其应用
EP4103168A4 (en) 2020-02-14 2024-04-24 Council Scient Ind Res PROCESS FOR THE PRODUCTION OF GAMMA-AMINOBUTRY ACIDS AND THEIR ANALOGUES
CN111205288B (zh) 2020-02-19 2021-03-30 四川大学 一种(1S,12bS)内酰胺酯化合物的合成方法
CN113651717A (zh) * 2021-08-05 2021-11-16 浙江工业大学 一种光学纯异丁基丁二腈的消旋方法
CN113880724A (zh) * 2021-12-06 2022-01-04 南京桦冠生物技术有限公司 一种3-(2-氨基苯基)-2-丙烯酸酯的制备方法

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HK1161307A1 (en) 2012-08-24
KR100847928B1 (ko) 2008-07-22
KR20080015153A (ko) 2008-02-18
CN102102114B (zh) 2013-08-14
CA2571040C (en) 2009-09-15
JP4800346B2 (ja) 2011-10-26
JP2008133289A (ja) 2008-06-12
MA28674B1 (fr) 2007-06-01
NO338097B1 (no) 2016-08-01
ES2336014T3 (es) 2010-04-07
PT1831154E (pt) 2010-02-19
GEP20104895B (en) 2010-02-25
DK1831154T3 (da) 2010-04-12
CA2571040A1 (en) 2006-01-05
CN1972904B (zh) 2011-02-02
TWI405747B (zh) 2013-08-21
EA200800908A1 (ru) 2008-12-30
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