EP4103168A4 - Process for the preparation of gamma amino butyric acids and analogs thereof - Google Patents
Process for the preparation of gamma amino butyric acids and analogs thereof Download PDFInfo
- Publication number
- EP4103168A4 EP4103168A4 EP21753915.4A EP21753915A EP4103168A4 EP 4103168 A4 EP4103168 A4 EP 4103168A4 EP 21753915 A EP21753915 A EP 21753915A EP 4103168 A4 EP4103168 A4 EP 4103168A4
- Authority
- EP
- European Patent Office
- Prior art keywords
- analogs
- preparation
- amino butyric
- butyric acids
- gamma amino
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- QWCKQJZIFLGMSD-UHFFFAOYSA-N alpha-aminobutyric acid Chemical class CCC(N)C(O)=O QWCKQJZIFLGMSD-UHFFFAOYSA-N 0.000 title 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C249/00—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton
- C07C249/04—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes
- C07C249/08—Preparation of compounds containing nitrogen atoms doubly-bound to a carbon skeleton of oximes by reaction of hydroxylamines with carbonyl compounds
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C227/00—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton
- C07C227/14—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof
- C07C227/18—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters
- C07C227/20—Preparation of compounds containing amino and carboxyl groups bound to the same carbon skeleton from compounds containing already amino and carboxyl groups or derivatives thereof by reactions involving amino or carboxyl groups, e.g. hydrolysis of esters or amides, by formation of halides, salts or esters by hydrolysis of N-acylated amino-acids or derivatives thereof, e.g. hydrolysis of carbamates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C231/00—Preparation of carboxylic acid amides
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C67/00—Preparation of carboxylic acid esters
- C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
- C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton
- C07C67/343—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms
- C07C67/347—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton by increase in the number of carbon atoms by addition to unsaturated carbon-to-carbon bonds
Landscapes
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN202011006475 | 2020-02-14 | ||
| PCT/IN2021/050141 WO2021161346A1 (en) | 2020-02-14 | 2021-02-13 | Process for the preparation of gamma amino butyric acids and analogs thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EP4103168A1 EP4103168A1 (en) | 2022-12-21 |
| EP4103168A4 true EP4103168A4 (en) | 2024-04-24 |
Family
ID=77293016
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EP21753915.4A Pending EP4103168A4 (en) | 2020-02-14 | 2021-02-13 | Process for the preparation of gamma amino butyric acids and analogs thereof |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP4103168A4 (en) |
| JP (1) | JP7436689B2 (en) |
| WO (1) | WO2021161346A1 (en) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116655482B (en) * | 2023-06-05 | 2024-06-04 | 贵州大学 | Preparation method of gamma-aminobutyric acid derivatives |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5072023A (en) * | 1990-02-15 | 1991-12-10 | E. R. Squibb & Sons, Inc. | Process for preparing highly substituted phenyls |
| JP2002241358A (en) * | 2001-02-15 | 2002-08-28 | Nippon Soda Co Ltd | Compound having oxim group and insecticide/miticide |
| JP4250887B2 (en) * | 2001-10-22 | 2009-04-08 | 三菱化学株式会社 | Method for producing amide compound |
| JP4562370B2 (en) * | 2003-10-02 | 2010-10-13 | 独立行政法人科学技術振興機構 | Method for producing rearranged unsaturated compound |
| AU2005256945B2 (en) * | 2004-06-21 | 2008-11-13 | Upjohn Us 1 Llc | Preparation of pregabalin and related compounds |
| US20070066846A1 (en) * | 2005-04-11 | 2007-03-22 | Asher Maymon | Process for making (S)-Pregabalin |
| US8293926B2 (en) * | 2005-12-09 | 2012-10-23 | Sumitomo Chemical Company, Limited | Method of producing optically active 4-amino-3-substituted phenylbutanoic acid |
| WO2008062460A2 (en) * | 2006-10-06 | 2008-05-29 | Cadila Healthcare Limited | Crystalline forms of pregabalin |
| SI2294207T1 (en) * | 2008-05-21 | 2013-01-31 | Sandoz Ag | Process for the stereoselective enzymatic hydrolysis of 5-methyl-3-nitromethyl-hexanoic acid ester |
| WO2010061403A2 (en) * | 2008-11-26 | 2010-06-03 | Ind-Swift Laboratories Limited | Process to prepare highly pure (s)-pregabalin |
| WO2012093411A2 (en) * | 2011-01-07 | 2012-07-12 | Dr Braja Sundar Pradhan | Process for the preparation of r-(-)-3- (carbamoylmethyl)-5-methylhexanoic acid and the intermediates |
| EP2916832B1 (en) * | 2012-11-07 | 2019-01-16 | Hikal Limited | A process for the preparation of pregabalin |
| JP6724283B2 (en) * | 2016-03-09 | 2020-07-15 | 国立大学法人 東京大学 | Process for producing optically active 4-nitrobutanoic acid ester and pregabalin |
-
2021
- 2021-02-13 JP JP2022548730A patent/JP7436689B2/en active Active
- 2021-02-13 EP EP21753915.4A patent/EP4103168A4/en active Pending
- 2021-02-13 WO PCT/IN2021/050141 patent/WO2021161346A1/en unknown
Non-Patent Citations (1)
| Title |
|---|
| H. ISHITANI, ET AL.: "Synthesis of (+/- )-pregabalin by utilising a three-step sequential-flow system with heterogeneous catalysts", EUROPEAN JOURNAL OF ORGANIC CHEMISTRY, vol. 2017, no. 44, 10 October 2017 (2017-10-10), Wiley-VCH Verlag, Weinheim, DE, pages 6491 - 6494, XP072119280, ISSN: 1434-193X, DOI: 10.1002/ejoc.201700998 * |
Also Published As
| Publication number | Publication date |
|---|---|
| EP4103168A1 (en) | 2022-12-21 |
| JP2023513330A (en) | 2023-03-30 |
| JP7436689B2 (en) | 2024-02-22 |
| WO2021161346A1 (en) | 2021-08-19 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EP3761980A4 (en) | Amino acid compounds and methods of use | |
| EP3761978A4 (en) | Inhibitors of protein arginine methyltransferase 5 (prmt5), pharmaceutical products thereof, and methods thereof | |
| EP3863711A4 (en) | Amino acid compounds and methods of use | |
| EP3517607A4 (en) | Novel aspartokinase mutant and method for production of l-amino acid using same | |
| EP3953337A4 (en) | Degraders of kelch-like ech-associated protein 1 (keap1) | |
| EP3845247A4 (en) | Application of amino acid nutrient, and pharmaceutical composition including amino acid nutrient | |
| EP3567110A4 (en) | Microorganism of genus corynebacterium for producing l-amino acid and method for producing l-amino acid by using same | |
| EP4047085A4 (en) | Novel branched-chain amino acid aminotransferase mutant and leucine production method using same | |
| PL4036143T3 (en) | Two-part phosphate ester elastomeric epoxy composition and method of use thereof | |
| EP3754024A4 (en) | Mycosporine-like amino acid-producing microorganism and method for production of mycosporine-like amino acids by using same | |
| EP4045036A4 (en) | Heteroaryl-biphenyl amides for the treatment of pd-l1 diseases | |
| WO2019224790A3 (en) | Prodrugs of fulvestrant | |
| EP3950676A4 (en) | Preparation method for amide compound and application thereof in field of medicine | |
| EP3969597A4 (en) | Compositions and methods for the treatment of atpase-mediated diseases | |
| EP3952874A4 (en) | Selective inhibitors of protein arginine methyltransferase 5 | |
| EP4102795A4 (en) | 1x ltf sequence for 320 mhz | |
| EP4103168A4 (en) | Process for the preparation of gamma amino butyric acids and analogs thereof | |
| WO2021100029A3 (en) | Prodrugs of fulvestrant | |
| EP3946352A4 (en) | Selective inhibitors of protein arginine methyltransferase 5 | |
| EP4041873A4 (en) | Proteins containing multiple, different unnatural amino acids and methods of making and using such proteins | |
| EP4034109A4 (en) | Method and composition for the treatment of disease | |
| EP3920956A4 (en) | Methods of using glycopolysialylated therapeutic proteins | |
| EP4003391A4 (en) | Peptides and methods of using the same | |
| EP3927684A4 (en) | Method of acylating amino acids and uses of n-acyl amino acid products | |
| EP4041218A4 (en) | Process for preparation of diroximel fumarate |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE |
|
| PUAI | Public reference made under article 153(3) epc to a published international application that has entered the european phase |
Free format text: ORIGINAL CODE: 0009012 |
|
| STAA | Information on the status of an ep patent application or granted ep patent |
Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE |
|
| 17P | Request for examination filed |
Effective date: 20220801 |
|
| AK | Designated contracting states |
Kind code of ref document: A1 Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR |
|
| DAV | Request for validation of the european patent (deleted) | ||
| DAX | Request for extension of the european patent (deleted) | ||
| P01 | Opt-out of the competence of the unified patent court (upc) registered |
Effective date: 20230626 |
|
| REG | Reference to a national code |
Ref country code: DE Ref legal event code: R079 Free format text: PREVIOUS MAIN CLASS: A61K0031197000 Ipc: C07C0227200000 |
|
| A4 | Supplementary search report drawn up and despatched |
Effective date: 20240321 |
|
| RIC1 | Information provided on ipc code assigned before grant |
Ipc: C07C 251/38 20060101ALI20240315BHEP Ipc: C07C 249/08 20060101ALI20240315BHEP Ipc: C07C 233/47 20060101ALI20240315BHEP Ipc: C07C 231/00 20060101ALI20240315BHEP Ipc: C07C 69/716 20060101ALI20240315BHEP Ipc: C07C 67/347 20060101ALI20240315BHEP Ipc: C07C 229/08 20060101ALI20240315BHEP Ipc: C07C 227/20 20060101AFI20240315BHEP |