EP4041218A4 - Process for preparation of diroximel fumarate - Google Patents

Process for preparation of diroximel fumarate Download PDF

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Publication number
EP4041218A4
EP4041218A4 EP20866544.8A EP20866544A EP4041218A4 EP 4041218 A4 EP4041218 A4 EP 4041218A4 EP 20866544 A EP20866544 A EP 20866544A EP 4041218 A4 EP4041218 A4 EP 4041218A4
Authority
EP
European Patent Office
Prior art keywords
preparation
diroximel fumarate
diroximel
fumarate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20866544.8A
Other languages
German (de)
French (fr)
Other versions
EP4041218A1 (en
Inventor
Prem Chand
Dipak Vinayak PATIL
Shekhar Ashok DESHMUKH
Sumit Vijayrao GAMPAWAR
Vijay Gulab GODASE
Samir Naik
Suresh Mahadev Kadam
Vishweshwar Peddy
Vinayak Kacheshwar BHUJADE
Shekhar Bhaskar Bhirud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Life Sciences Ltd
Original Assignee
Glenmark Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Life Sciences Ltd filed Critical Glenmark Life Sciences Ltd
Publication of EP4041218A1 publication Critical patent/EP4041218A1/en
Publication of EP4041218A4 publication Critical patent/EP4041218A4/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP20866544.8A 2019-09-16 2020-09-11 Process for preparation of diroximel fumarate Pending EP4041218A4 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201921037120 2019-09-16
IN201921042111 2019-10-17
PCT/IB2020/058454 WO2021053476A1 (en) 2019-09-16 2020-09-11 Process for preparation of diroximel fumarate

Publications (2)

Publication Number Publication Date
EP4041218A1 EP4041218A1 (en) 2022-08-17
EP4041218A4 true EP4041218A4 (en) 2023-12-27

Family

ID=74883994

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20866544.8A Pending EP4041218A4 (en) 2019-09-16 2020-09-11 Process for preparation of diroximel fumarate

Country Status (2)

Country Link
EP (1) EP4041218A4 (en)
WO (1) WO2021053476A1 (en)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2022291752A1 (en) * 2021-06-15 2024-01-04 Biogen Ma Inc. Synthetic preparation for diroximel fumarate
CA3231790A1 (en) * 2021-09-17 2023-03-23 Liang Chen Diroximel fumarate particles having improved flow properties and methods of making same

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA795368A (en) * 1968-09-24 Dowbenko Rostyslaw Isomerization of maleates with thionyl chloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SI3253377T1 (en) * 2015-02-08 2021-08-31 Alkermes Pharma Ireland Limited Monomethylfumarate prodrug compositions
WO2017108960A1 (en) * 2015-12-22 2017-06-29 Ratiopharm Gmbh Method for producing monomethyl fumarate compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA795368A (en) * 1968-09-24 Dowbenko Rostyslaw Isomerization of maleates with thionyl chloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HURST JAMES K. ET AL: "The reduction by metal ions of fumaratopentaamminecobalt(III) complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 90, no. 5, 1 February 1968 (1968-02-01), pages 1178 - 1186, XP093074429, ISSN: 0002-7863, DOI: 10.1021/ja01007a014 *
See also references of WO2021053476A1 *

Also Published As

Publication number Publication date
EP4041218A1 (en) 2022-08-17
WO2021053476A1 (en) 2021-03-25

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Ipc: C07C 69/60 20060101ALI20230822BHEP

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