EP4041218A4 - Verfahren zum herstellen von dibromfumarat - Google Patents

Verfahren zum herstellen von dibromfumarat Download PDF

Info

Publication number
EP4041218A4
EP4041218A4 EP20866544.8A EP20866544A EP4041218A4 EP 4041218 A4 EP4041218 A4 EP 4041218A4 EP 20866544 A EP20866544 A EP 20866544A EP 4041218 A4 EP4041218 A4 EP 4041218A4
Authority
EP
European Patent Office
Prior art keywords
preparation
diroximel fumarate
diroximel
fumarate
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
EP20866544.8A
Other languages
English (en)
French (fr)
Other versions
EP4041218A1 (de
Inventor
Prem Chand
Dipak Vinayak PATIL
Shekhar Ashok DESHMUKH
Sumit Vijayrao GAMPAWAR
Vijay Gulab GODASE
Samir Naik
Suresh Mahadev Kadam
Vishweshwar Peddy
Vinayak Kacheshwar BHUJADE
Shekhar Bhaskar Bhirud
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Glenmark Life Sciences Ltd
Original Assignee
Glenmark Life Sciences Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glenmark Life Sciences Ltd filed Critical Glenmark Life Sciences Ltd
Publication of EP4041218A1 publication Critical patent/EP4041218A1/de
Publication of EP4041218A4 publication Critical patent/EP4041218A4/de
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/30—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D207/34—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/36—Oxygen or sulfur atoms
    • C07D207/40—2,5-Pyrrolidine-diones
    • C07D207/404—2,5-Pyrrolidine-diones with only hydrogen atoms or radicals containing only hydrogen and carbon atoms directly attached to other ring carbon atoms, e.g. succinimide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/08—Preparation of carboxylic acid esters by reacting carboxylic acids or symmetrical anhydrides with the hydroxy or O-metal group of organic compounds
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C67/00—Preparation of carboxylic acid esters
    • C07C67/30—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group
    • C07C67/333—Preparation of carboxylic acid esters by modifying the acid moiety of the ester, such modification not being an introduction of an ester group by isomerisation; by change of size of the carbon skeleton

Landscapes

  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Neurosurgery (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Psychiatry (AREA)
  • Hospice & Palliative Care (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
EP20866544.8A 2019-09-16 2020-09-11 Verfahren zum herstellen von dibromfumarat Pending EP4041218A4 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201921037120 2019-09-16
IN201921042111 2019-10-17
PCT/IB2020/058454 WO2021053476A1 (en) 2019-09-16 2020-09-11 Process for preparation of diroximel fumarate

Publications (2)

Publication Number Publication Date
EP4041218A1 EP4041218A1 (de) 2022-08-17
EP4041218A4 true EP4041218A4 (de) 2023-12-27

Family

ID=74883994

Family Applications (1)

Application Number Title Priority Date Filing Date
EP20866544.8A Pending EP4041218A4 (de) 2019-09-16 2020-09-11 Verfahren zum herstellen von dibromfumarat

Country Status (2)

Country Link
EP (1) EP4041218A4 (de)
WO (1) WO2021053476A1 (de)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN117813285A (zh) * 2021-06-15 2024-04-02 渤健马萨诸塞州股份有限公司 富马酸地洛西美的合成制备
IL311498A (en) * 2021-09-17 2024-05-01 Biogen Ma Inc Diroxymal fumarate particles with improved flow properties and methods for their preparation

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA795368A (en) * 1968-09-24 Dowbenko Rostyslaw Isomerization of maleates with thionyl chloride

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS62186B1 (sr) * 2015-02-08 2021-08-31 Alkermes Pharma Ireland Ltd Kompozicije proleka na bazi monometil fumarata
WO2017108960A1 (en) * 2015-12-22 2017-06-29 Ratiopharm Gmbh Method for producing monomethyl fumarate compounds

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA795368A (en) * 1968-09-24 Dowbenko Rostyslaw Isomerization of maleates with thionyl chloride

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
HURST JAMES K. ET AL: "The reduction by metal ions of fumaratopentaamminecobalt(III) complexes", JOURNAL OF THE AMERICAN CHEMICAL SOCIETY, vol. 90, no. 5, 1 February 1968 (1968-02-01), pages 1178 - 1186, XP093074429, ISSN: 0002-7863, DOI: 10.1021/ja01007a014 *
See also references of WO2021053476A1 *

Also Published As

Publication number Publication date
WO2021053476A1 (en) 2021-03-25
EP4041218A1 (de) 2022-08-17

Similar Documents

Publication Publication Date Title
AU2019382117A1 (en) Process for the preparation of (S)-nicotin from myosmine
EP3717457A4 (de) Verfahren zur herstellung von enzalutamid unter verwendung eines neuen zwischenproduktes
EP3694499A4 (de) Neuartiges verfahren zur herstellung von lifitegrast
EP3953376A4 (de) Verfahren zur synthese von beta-homoaminosäuren
EP3504221A4 (de) Neuartiges verfahren zur herstellung von corticosteroiden
SG11202108238VA (en) Process for the preparation of methionine
EP3615205A4 (de) Verfahren zur herstellung von deuteriertem ethanol aus d2
EP4041218A4 (de) Verfahren zum herstellen von dibromfumarat
EP3891114A4 (de) Verfahren zur herstellung von hochreinem trifluoriodmethan
IL290181A (en) Process for the preparation of Fluensulfone
EP3696168A4 (de) Verfahren zur herstellung von 2-chlor-5-trifluormethylpyridin
EP3565552A4 (de) Verbessertes verfahren zur herstellung von rivaroxaban mit neuartigem zwischenprodukt
EP3941902A4 (de) Verfahren zur herstellung von trifluormethansulfinylchlorid
EP3914602A4 (de) Verfahren zur herstellung von l-fucose
EP3762356A4 (de) Verbessertes verfahren zur herstellung von zwischenprodukten
EP3727377A4 (de) Verfahren zur herstellung von pyrimidinyl-4-aminopyrazolverbindungen
EP3989975A4 (de) Verfahren zur herstellung von abrocitinib
IL289904A (en) A process for preparing biphenylamines
EP4061132A4 (de) Verfahren zur herstellung von chlorantraniliprol
EP4077278A4 (de) Verfahren zur herstellung von brivaracetam
EP3911660A4 (de) Verfahren zur herstellung von 2-amino-5-hydroxypropiophenon
EP4021920A4 (de) Verbessertes verfahren zur herstellung von etelcalcetid-hydrochlorid
EP4096662A4 (de) Verfahren zur herstellung von lasmiditan
EP3813532A4 (de) Verfahren zur herstellung von quinmerac
EP3902792A4 (de) Verfahren zur herstellung von anthranilamiden

Legal Events

Date Code Title Description
STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: THE INTERNATIONAL PUBLICATION HAS BEEN MADE

PUAI Public reference made under article 153(3) epc to a published international application that has entered the european phase

Free format text: ORIGINAL CODE: 0009012

STAA Information on the status of an ep patent application or granted ep patent

Free format text: STATUS: REQUEST FOR EXAMINATION WAS MADE

17P Request for examination filed

Effective date: 20220414

AK Designated contracting states

Kind code of ref document: A1

Designated state(s): AL AT BE BG CH CY CZ DE DK EE ES FI FR GB GR HR HU IE IS IT LI LT LU LV MC MK MT NL NO PL PT RO RS SE SI SK SM TR

DAV Request for validation of the european patent (deleted)
DAX Request for extension of the european patent (deleted)
P01 Opt-out of the competence of the unified patent court (upc) registered

Effective date: 20230602

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 69/60 20060101ALI20230822BHEP

Ipc: A61K 31/225 20060101AFI20230822BHEP

A4 Supplementary search report drawn up and despatched

Effective date: 20231128

RIC1 Information provided on ipc code assigned before grant

Ipc: C07C 69/60 20060101ALI20231122BHEP

Ipc: A61K 31/225 20060101AFI20231122BHEP