EA200600295A1 - Диарильные и арилгетероарильные производные мочевины в качестве модуляторов 5-ht-рецептора серотонина, пригодные для профилактики и лечения связанных с ним заболеваний - Google Patents

Диарильные и арилгетероарильные производные мочевины в качестве модуляторов 5-ht-рецептора серотонина, пригодные для профилактики и лечения связанных с ним заболеваний

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EA200600295A1
EA200600295A1 EA200600295A EA200600295A EA200600295A1 EA 200600295 A1 EA200600295 A1 EA 200600295A1 EA 200600295 A EA200600295 A EA 200600295A EA 200600295 A EA200600295 A EA 200600295A EA 200600295 A1 EA200600295 A1 EA 200600295A1
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Eurasian Patent Office
Prior art keywords
psychosis
receptor
serotonin
schizophrenia
prevention
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EA200600295A
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English (en)
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EA009732B1 (ru
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Бредли Тигарден
Хоннаппа Йаякумар
Хунмэй Ли
Соня Страх-Плейнет
Петер Ян Доса
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Арена Фармасьютикалз, Инк.
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Publication of EA200600295A1 publication Critical patent/EA200600295A1/ru
Publication of EA009732B1 publication Critical patent/EA009732B1/ru

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Abstract

Данное изобретение относится к некоторым пиразольным производным формулы (I) и их фармацевтическим композициям, которые модулируют активность 5-НТ-рецептора серотонина. Соединения и их фармацевтические композиции направлены на способы, пригодные для профилактики или лечения агрегации тромбоцитов, болезней коронарных артерий, инфаркта миокарда, быстро преходящих приступов ишемии, стенокардии, удара, фибрилляции предсердий, снижения риска образования сгустков крови, астмы или ее симптомов, ажитации или ее симптомов, поведенческих расстройств, вызываемого лекарствами психоза, реактивного психоза, синдрома Жиля де ла Турретта, маниакального синдрома, органического или NOS психоза, психотического расстройства, психоза, острой шизофрении, хронической шизофрении, NOS шизофрении и родственных заболеваний, и расстройств сна, связанных с диабетом расстройств и т.п. Настоящее изобретение относится также к способу профилактики или лечения заболеваний, которые опосредуются 5-HT-рецептором серотонина, в сочетании с антагонистом D2-рецептора допамина, таким как галоперидол, который вводят отдельно или совместно.
EA200600295A 2003-07-22 2004-07-21 Диарильные и арилгетероарильные производные мочевины в качестве модуляторов 5-ht-рецептора серотонина, пригодные для профилактики и лечения связанных с ним заболеваний EA009732B1 (ru)

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US48957203P 2003-07-22 2003-07-22
US50358603P 2003-09-16 2003-09-16
PCT/US2004/023488 WO2005012254A1 (en) 2003-07-22 2004-07-21 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto

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EA200600295A1 true EA200600295A1 (ru) 2006-08-25
EA009732B1 EA009732B1 (ru) 2008-02-28

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CN1826322B (zh) 2003-07-22 2012-04-18 艾尼纳制药公司 用于预防和治疗相关病症而作为5-ht2a血清素受体调节剂的二芳基和芳基杂芳基脲衍生物
CA2559038C (en) 2004-03-23 2013-09-10 Arena Pharmaceuticals, Inc. Processes for preparing substituted n-aryl-n'-[3-(1h-pyrazol-5-yl) phenyl] ureas and intermediates thereof
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