BRPI0412263A - derivados de diaril e arileteroaril uréia como moduladores do receptor de serotonina de 5-ht2a úteis para a profilaxia e tratamento de desordens relacionadas aos mesmos - Google Patents

derivados de diaril e arileteroaril uréia como moduladores do receptor de serotonina de 5-ht2a úteis para a profilaxia e tratamento de desordens relacionadas aos mesmos

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Publication number
BRPI0412263A
BRPI0412263A BRPI0412263-1A BRPI0412263A BRPI0412263A BR PI0412263 A BRPI0412263 A BR PI0412263A BR PI0412263 A BRPI0412263 A BR PI0412263A BR PI0412263 A BRPI0412263 A BR PI0412263A
Authority
BR
Brazil
Prior art keywords
treatment
serotonin receptor
related disorders
prophylaxis
psychosis
Prior art date
Application number
BRPI0412263-1A
Other languages
English (en)
Inventor
Bradley Teegarden
Honnappa Jayakumar
Hongmei Li
Sonja Strah-Pleynet
Peter Ian Dosa
Original Assignee
Arena Pharm Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Arena Pharm Inc filed Critical Arena Pharm Inc
Publication of BRPI0412263A publication Critical patent/BRPI0412263A/pt
Publication of BRPI0412263B1 publication Critical patent/BRPI0412263B1/pt

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    • A61K31/41—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with two or more ring hetero atoms, at least one of which being nitrogen, e.g. tetrazole
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
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    • A61K31/5375—1,4-Oxazines, e.g. morpholine
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Abstract

"DERIVADOS DE DIARIL E ARILETEROARIL URéIA COMO MODULADORES DO RECEPTOR DE SEROTONINA DE 5-HT2A úTEIS PARA A PROFILAXIA E TRATAMENTO DE DESORDENS RELACIONADAS AOS MESMOS". A presente invenção refere-se a certos derivados de pirazóis da fórmula (I) e suas composições farmacêuticas que modulam a atividade do receptor de serotonina de 5-HT~ 2A~. Compostos e suas composições farmacêuticas referem-se a métodos úteis na profilaxia ou tratamento de agregação de plaquetas, doença de artéria coronária, infarto do miocardio, ataque isquêmico transitório, angina, acidente vascular cerebral, fibrilação arterial, reducing the risk de formação de coágulo de sangue, asma ou seus sintomas, agitação ou um sintoma, desordens comportamentais, psicose induzida pela droga, psicose excitativa, síndrome de Gilles de la Tourette, desordem maníaca, psicose orgânica ou de NOS, desordem psicótica, psicose, esquizofrenia aguda, esquizofrenia crónica, esquizofrenia de NOS e desordens relacionadas, e desordens de sono, desordens relacionadas diabéticas e e semelhantes. A presente invenção também refere-se ao método de profilaxia ou tratamento de desordens mediadas por receptor de serotonina de 5-HT~ 2A~ em combinação com um antagonista de receptor de dopamina D2 tal como, haloperidol, adminstrado separadamente ou junto.
BRPI0412263-1A 2003-07-22 2004-07-21 Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição BRPI0412263B1 (pt)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US48957203P 2003-07-22 2003-07-22
US60/489,572 2003-07-22
US50358603P 2003-09-16 2003-09-16
US60/503,586 2003-09-16
PCT/US2004/023488 WO2005012254A1 (en) 2003-07-22 2004-07-21 Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related therto

Publications (2)

Publication Number Publication Date
BRPI0412263A true BRPI0412263A (pt) 2006-09-19
BRPI0412263B1 BRPI0412263B1 (pt) 2019-10-15

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BRPI0412263-1A BRPI0412263B1 (pt) 2003-07-22 2004-07-21 Derivados de diaril e aril heteroaril uréia, uso e composição farmacêutica contendo os mesmos, bem como processo para preparação da dita composição

Country Status (30)

Country Link
US (9) US8754238B2 (pt)
EP (1) EP1558582B1 (pt)
JP (3) JP4198733B2 (pt)
KR (1) KR101157272B1 (pt)
CN (3) CN101875961B (pt)
AR (1) AR045069A1 (pt)
AT (1) ATE313532T1 (pt)
AU (1) AU2004261582C1 (pt)
BR (1) BRPI0412263B1 (pt)
CA (1) CA2533369C (pt)
DE (1) DE602004000260T2 (pt)
DK (1) DK1558582T3 (pt)
EA (1) EA009732B1 (pt)
EC (1) ECSP066269A (pt)
ES (1) ES2258760T3 (pt)
HK (1) HK1072943A1 (pt)
HR (1) HRP20060100T3 (pt)
IL (1) IL172582A0 (pt)
IS (1) IS2232B (pt)
MA (1) MA28066A1 (pt)
MX (1) MXPA06000795A (pt)
MY (1) MY141862A (pt)
NO (1) NO20060877L (pt)
NZ (1) NZ544331A (pt)
PL (1) PL1558582T3 (pt)
PT (1) PT1558582E (pt)
RS (1) RS20060035A (pt)
TN (1) TNSN06017A1 (pt)
TW (1) TW200523253A (pt)
WO (1) WO2005012254A1 (pt)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RS20060035A (en) 2003-07-22 2008-08-07 Arena Pharmaceuticals Inc., Diaryl and arylheteroaryl urea derivatives as modulators of the 5-ht2a serotonin receptor useful for the prophylaxis and treatment of disorders related thereto
EP1727803B3 (en) * 2004-03-23 2014-04-23 Arena Pharmaceuticals, Inc. Processes for preparing substituted n-aryl-n'-[3-(1h-pyrazol-5-yl)phenyl] ureas and intermediates thereof
SA05260357B1 (ar) 2004-11-19 2008-09-08 ارينا فارماسيتو تيكالز ، أنك مشتقات 3_فينيل_بيرازول كمعدلات لمستقبل سيروتينين 5_ht2a مفيدة في علاج الاضطرابات المتعلقه به
US20080015223A1 (en) * 2004-12-03 2008-01-17 Arena Pharmaceuticals, Inc. Pyrazole Derivatives as Modulators of the 5-Ht2a Serotonin Receptor Useful for the Treatment of Disorders Related Thereto
US20080200530A1 (en) * 2005-01-19 2008-08-21 Unett David J Diaryl and Arylheteroaryl Urea Derivatives as Modulators of 5-Ht2a Serotonin Receptor Useful for the Prophylaxis or Treatment of Progressive Multifocal Leukoencephalopathy
AR052886A1 (es) * 2005-01-26 2007-04-11 Arena Pharm Inc Procedimientos para preparar fenilpirazol ureas sustituidas y para la obtencion de sus intermediarios de sintesis
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