BR9808938A - Composto, composição farmacêutica, uso de um composto, processos para o tratamento de um distúrbio ou doença de um corpo de animal vivo e para a preparação de um composto, e, uso de bloqueadores de canal de cloreto - Google Patents

Composto, composição farmacêutica, uso de um composto, processos para o tratamento de um distúrbio ou doença de um corpo de animal vivo e para a preparação de um composto, e, uso de bloqueadores de canal de cloreto

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Publication number
BR9808938A
BR9808938A BR9808938-2A BR9808938A BR9808938A BR 9808938 A BR9808938 A BR 9808938A BR 9808938 A BR9808938 A BR 9808938A BR 9808938 A BR9808938 A BR 9808938A
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compound
disorder
disease
treating
processes
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BR9808938-2A
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English (en)
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Palle Christophersen
Ove Pedersen
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Neurosearch As
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/42—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12—Antidiarrhoeals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P19/00—Drugs for skeletal disorders
    • A61P19/08—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease
    • A61P19/10—Drugs for skeletal disorders for bone diseases, e.g. rachitism, Paget's disease for osteoporosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P27/00—Drugs for disorders of the senses
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    • A61P27/06—Antiglaucoma agents or miotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P3/00—Drugs for disorders of the metabolism
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/08—Antiallergic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid
    • A61P7/06—Antianaemics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/12—Antihypertensives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C233/00—Carboxylic acid amides
    • C07C233/01—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms
    • C07C233/45—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups
    • C07C233/53—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring
    • C07C233/55—Carboxylic acid amides having carbon atoms of carboxamide groups bound to hydrogen atoms or to acyclic carbon atoms having the nitrogen atom of at least one of the carboxamide groups bound to a carbon atom of a hydrocarbon radical substituted by carboxyl groups with the substituted hydrocarbon radical bound to the nitrogen atom of the carboxamide group by a carbon atom of a six-membered aromatic ring having the carbon atom of the carboxamide group bound to a carbon atom of an unsaturated carbon skeleton
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C271/00—Derivatives of carbamic acids, i.e. compounds containing any of the groups, the nitrogen atom not being part of nitro or nitroso groups
    • C07C271/06—Esters of carbamic acids
    • C07C271/40—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings
    • C07C271/58—Esters of carbamic acids having oxygen atoms of carbamate groups bound to carbon atoms of six-membered aromatic rings with the nitrogen atom of at least one of the carbamate groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C275/00—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C275/28—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C275/40—Derivatives of urea, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups having nitrogen atoms of urea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by nitrogen atoms not being part of nitro or nitroso groups
    • C—CHEMISTRY; METALLURGY
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C309/00—Sulfonic acids; Halides, esters, or anhydrides thereof
    • C07C309/01—Sulfonic acids
    • C07C309/28—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C309/45—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton
    • C07C309/51—Sulfonic acids having sulfo groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton containing nitrogen atoms, not being part of nitro or nitroso groups, bound to the carbon skeleton at least one of the nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/01—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms
    • C07C311/02—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton
    • C07C311/08—Sulfonamides having sulfur atoms of sulfonamide groups bound to acyclic carbon atoms of an acyclic saturated carbon skeleton having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/15—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/21—Sulfonamides having sulfur atoms of sulfonamide groups bound to carbon atoms of six-membered aromatic rings having the nitrogen atom of at least one of the sulfonamide groups bound to a carbon atom of a six-membered aromatic ring
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/30—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/45—Sulfonamides, the carbon skeleton of the acid part being further substituted by singly-bound nitrogen atoms, not being part of nitro or nitroso groups at least one of the singly-bound nitrogen atoms being part of any of the groups, X being a hetero atom, Y being any atom, e.g. N-acylaminosulfonamides
    • C07C311/47—Y being a hetero atom
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    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C311/00—Amides of sulfonic acids, i.e. compounds having singly-bound oxygen atoms of sulfo groups replaced by nitrogen atoms, not being part of nitro or nitroso groups
    • C07C311/50—Compounds containing any of the groups, X being a hetero atom, Y being any atom
    • C07C311/52—Y being a hetero atom
    • C07C311/54—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea
    • C07C311/57—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
    • C07C311/60—Y being a hetero atom either X or Y, but not both, being nitrogen atoms, e.g. N-sulfonylurea having sulfur atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings having nitrogen atoms of the sulfonylurea groups bound to carbon atoms of six-membered aromatic rings
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    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C335/00—Thioureas, i.e. compounds containing any of the groups, the nitrogen atoms not being part of nitro or nitroso groups
    • C07C335/04—Derivatives of thiourea
    • C07C335/16—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton
    • C07C335/22—Derivatives of thiourea having nitrogen atoms of thiourea groups bound to carbon atoms of six-membered aromatic rings of a carbon skeleton being further substituted by carboxyl groups

Abstract

"COMPOSTO, COMPOSIçãO FARMACêUTICA, USO DE UM COMPOSTO, PROCESSOS PARA O TRATAMENTO DE UM DISTúRBIO OU DOENçA DE UM CORPO DE ANIMAL VIVO E PARA A PREPARAçãO DE UM COMPOSTO, E, USO DE BLOQUEADORES DE CANAL DE CLORETO" Um composto que tem a fórmula (I): ou um sal deste, farmaceuticamente aceitável, em que um de R^ 1^, R^ 2^ e R^ 3^ é um grupo funcional ácido cíclico ou heterocíclico que têm um valor de pKa abaixo de 8 ou um grupo que é convertível in vivo em um tal grupo; R^ 4^, R^ 5^ e os dois outros substituintes R^ 1^, R^ 2^ e R^ 3^, são cada um independentemente selecionados do hidrogênio; alquila; alcóxi; hidróxi; halogênio; trifluorometila; ciano; nitro; amino; alquilamino; -COOR^ 7^; -NHSO~ 2~-alquila; -SO~ 2~N(R^ 7^)~ 2~; -SO~ 2~OR^ 7^; -CO-R^ 7^; arila, bifenila, fenilamino, fenóxi ou heteroarila, em que o grupo arila, bifenila, fenilamino, fenóxi ou heteroarila pode ser substituído uma ou duas vezes com substituintes selecionados de alquila, hidróxi, alcóxi, halogênio; trifluorometila, ciano, nitro, amino e alquilamino; arila e heteroarila, ou R^ 3^ e R^ 4^ ou R^ 4^ e R^ 5^ juntos formam uma estrutura cíclica e os outros substituintes R^ 1^, R^ 2^, R^ 3^, R^ 4^ e R^ 5^ são como definidos acima; e R^ 7^ é hidrogênio, alquila, amino ou fenila; Y é -CO-, -CS-, -SO~ 2~- ou -C(=N-R^ 8^)-, em que R^ 8^ é hidrogênio, alquila ou ciano; X é -NH-, -CH~ 2~-NH- ou -SO~ 2~-NH-; Z é NR^ 6^, O, -CH=CH-, -N=CH- ou -CH=N-; R^ 6^ é hidrogênio, ou alquila; R^ 11^, R^ 12^, R^ 13^, R^ 14^ e R^ 15^ são cada um independentemente, selecionados de hidrogênio; alquila; alcóxi; hidróxi; halogênio; trifluorometila; ciano; nitro; amino; alquilamino; -COOR^ 7^; -NHSO~ 2~-alquila; -SO~ 2~N(R^ 7^)~ 2~; -SO~ 2~OR^ 7^; -CO-R^ 7^; arila, bifenila, fenilamino, fenóxi ou heteroarila, em que o grupo arila, bifenila, fenilamino, fenóxi ou heteroarila pode ser substituído uma ou duas vezes com substituintes selecionados de alquila, hidróxi, alcóxi, halogênio; trifluorometila, ciano, nitro, amino e alquilamino; arila e heteroarila ou um de R^ 11^ e R^ 12^, R^ 12^ e R^ 13^, R^ 13^ e R^ 14^ e R^ 14^ e R^ 15^ juntos formam uma estrutura cíclica e os outros substituintes R^ 11^, R^ 12^, R^ 13^, R^ 14^ e R^ 15^ são como definidos acima e R^ 7^ é como definido acima; estes compostos são particularmente úteis no tratamento da anemia de células falciformes.
BR9808938-2A 1997-04-22 1998-04-21 Composto, composição farmacêutica, uso de um composto, processos para o tratamento de um distúrbio ou doença de um corpo de animal vivo e para a preparação de um composto, e, uso de bloqueadores de canal de cloreto BR9808938A (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
DK45297 1997-04-22
PCT/DK1998/000162 WO1998047879A1 (en) 1997-04-22 1998-04-21 Substituted phenyl derivatives, their preparation and use

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BR9808938A true BR9808938A (pt) 2000-08-01

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BR9808938-2A BR9808938A (pt) 1997-04-22 1998-04-21 Composto, composição farmacêutica, uso de um composto, processos para o tratamento de um distúrbio ou doença de um corpo de animal vivo e para a preparação de um composto, e, uso de bloqueadores de canal de cloreto

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US (1) US6297261B1 (pt)
EP (1) EP0977741B1 (pt)
JP (1) JP2001521532A (pt)
CN (1) CN1118462C (pt)
AT (1) ATE248824T1 (pt)
AU (1) AU728520B2 (pt)
BR (1) BR9808938A (pt)
CA (1) CA2285424A1 (pt)
CZ (1) CZ295822B6 (pt)
DE (1) DE69817802T2 (pt)
DK (1) DK0977741T3 (pt)
ES (1) ES2205472T3 (pt)
HK (1) HK1026909A1 (pt)
IL (1) IL132107A (pt)
NZ (1) NZ337976A (pt)
PT (1) PT977741E (pt)
RU (1) RU2197482C2 (pt)
SK (1) SK282818B6 (pt)
TR (1) TR199902593T2 (pt)
WO (1) WO1998047879A1 (pt)

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PT977741E (pt) 2004-01-30
EP0977741A1 (en) 2000-02-09
DE69817802D1 (de) 2003-10-09
RU2197482C2 (ru) 2003-01-27
DE69817802T2 (de) 2004-04-08
HK1026909A1 (en) 2000-12-29
ATE248824T1 (de) 2003-09-15
TR199902593T2 (xx) 2000-03-21
SK144799A3 (en) 2000-05-16
NZ337976A (en) 2001-05-25
WO1998047879A1 (en) 1998-10-29
CZ295822B6 (cs) 2005-11-16
CA2285424A1 (en) 1998-10-29
AU6919698A (en) 1998-11-13
ES2205472T3 (es) 2004-05-01
AU728520B2 (en) 2001-01-11
CZ369999A3 (cs) 2000-02-16
JP2001521532A (ja) 2001-11-06
DK0977741T3 (da) 2003-12-01
SK282818B6 (sk) 2002-12-03
IL132107A0 (en) 2001-03-19
US6297261B1 (en) 2001-10-02
CN1118462C (zh) 2003-08-20
IL132107A (en) 2004-09-27
EP0977741B1 (en) 2003-09-03

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