EA004796B1 - Инфекционные клоны вируса ньюкаслской болезни, вакцины и диагностические анализы - Google Patents
Инфекционные клоны вируса ньюкаслской болезни, вакцины и диагностические анализы Download PDFInfo
- Publication number
- EA004796B1 EA004796B1 EA200100057A EA200100057A EA004796B1 EA 004796 B1 EA004796 B1 EA 004796B1 EA 200100057 A EA200100057 A EA 200100057A EA 200100057 A EA200100057 A EA 200100057A EA 004796 B1 EA004796 B1 EA 004796B1
- Authority
- EA
- Eurasian Patent Office
- Prior art keywords
- cdna
- protein
- virus
- νών
- vaccine
- Prior art date
Links
- 229960005486 vaccine Drugs 0.000 title claims abstract description 124
- 208000015181 infectious disease Diseases 0.000 title claims abstract description 99
- 230000002458 infectious effect Effects 0.000 title claims abstract description 71
- 241000711404 Avian avulavirus 1 Species 0.000 title claims abstract description 24
- 238000003556 assay Methods 0.000 title 1
- 108090000623 proteins and genes Proteins 0.000 claims abstract description 222
- 241000700605 Viruses Species 0.000 claims abstract description 192
- 239000002299 complementary DNA Substances 0.000 claims abstract description 133
- 102000004169 proteins and genes Human genes 0.000 claims abstract description 122
- 238000000034 method Methods 0.000 claims abstract description 87
- 241000271566 Aves Species 0.000 claims abstract description 76
- 238000003776 cleavage reaction Methods 0.000 claims abstract description 40
- 230000007017 scission Effects 0.000 claims abstract description 40
- 241000287828 Gallus gallus Species 0.000 claims abstract description 25
- 235000013330 chicken meat Nutrition 0.000 claims abstract description 25
- 150000007523 nucleic acids Chemical group 0.000 claims abstract description 25
- 241001465754 Metazoa Species 0.000 claims abstract description 23
- 108091005804 Peptidases Proteins 0.000 claims abstract description 22
- 239000004365 Protease Substances 0.000 claims abstract description 22
- 239000000427 antigen Substances 0.000 claims abstract description 22
- 108091007433 antigens Proteins 0.000 claims abstract description 22
- 102000036639 antigens Human genes 0.000 claims abstract description 22
- 244000144977 poultry Species 0.000 claims abstract description 21
- 235000013594 poultry meat Nutrition 0.000 claims abstract description 21
- 102000039446 nucleic acids Human genes 0.000 claims abstract description 18
- 108020004707 nucleic acids Proteins 0.000 claims abstract description 18
- 230000003612 virological effect Effects 0.000 claims abstract description 18
- 108010067390 Viral Proteins Proteins 0.000 claims abstract description 17
- 239000012530 fluid Substances 0.000 claims abstract description 17
- 230000004048 modification Effects 0.000 claims abstract description 17
- 238000012986 modification Methods 0.000 claims abstract description 17
- 230000002797 proteolythic effect Effects 0.000 claims abstract description 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims abstract description 14
- 230000037430 deletion Effects 0.000 claims abstract description 14
- 238000012217 deletion Methods 0.000 claims abstract description 14
- 244000052769 pathogen Species 0.000 claims abstract description 13
- 230000004927 fusion Effects 0.000 claims abstract description 11
- 230000001717 pathogenic effect Effects 0.000 claims abstract description 8
- 230000003362 replicative effect Effects 0.000 claims abstract description 7
- 208000035473 Communicable disease Diseases 0.000 claims abstract description 4
- 238000009007 Diagnostic Kit Methods 0.000 claims abstract description 4
- 101710133291 Hemagglutinin-neuraminidase Proteins 0.000 claims abstract description 4
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims abstract description 4
- 239000011159 matrix material Substances 0.000 claims abstract description 4
- 102100037486 Reverse transcriptase/ribonuclease H Human genes 0.000 claims abstract 5
- 208000010359 Newcastle Disease Diseases 0.000 claims description 19
- 230000003308 immunostimulating effect Effects 0.000 claims description 15
- 238000001890 transfection Methods 0.000 claims description 14
- 238000004519 manufacturing process Methods 0.000 claims description 10
- 235000015097 nutrients Nutrition 0.000 claims description 5
- 239000002243 precursor Substances 0.000 claims description 3
- 108010089430 Phosphoproteins Proteins 0.000 claims description 2
- 102000007982 Phosphoproteins Human genes 0.000 claims description 2
- 201000011510 cancer Diseases 0.000 claims description 2
- 239000003550 marker Substances 0.000 abstract description 24
- 239000001963 growth medium Substances 0.000 abstract description 10
- 108020001507 fusion proteins Proteins 0.000 abstract description 6
- 102000037865 fusion proteins Human genes 0.000 abstract description 6
- 108010068327 4-hydroxyphenylpyruvate dioxygenase Proteins 0.000 abstract 1
- 239000013612 plasmid Substances 0.000 description 177
- 210000004027 cell Anatomy 0.000 description 160
- 239000002773 nucleotide Substances 0.000 description 93
- 125000003729 nucleotide group Chemical group 0.000 description 92
- 238000003752 polymerase chain reaction Methods 0.000 description 83
- 239000013615 primer Substances 0.000 description 79
- 239000012634 fragment Substances 0.000 description 78
- 108091032973 (ribonucleotides)n+m Proteins 0.000 description 58
- 230000014509 gene expression Effects 0.000 description 42
- 238000012360 testing method Methods 0.000 description 40
- 108091008146 restriction endonucleases Proteins 0.000 description 36
- 108020004414 DNA Proteins 0.000 description 33
- 238000013518 transcription Methods 0.000 description 32
- 230000035897 transcription Effects 0.000 description 32
- 201000010099 disease Diseases 0.000 description 31
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 31
- 239000000203 mixture Substances 0.000 description 31
- 150000001413 amino acids Chemical group 0.000 description 30
- 238000002255 vaccination Methods 0.000 description 30
- 230000010076 replication Effects 0.000 description 28
- 238000010367 cloning Methods 0.000 description 24
- 238000006243 chemical reaction Methods 0.000 description 23
- 230000001018 virulence Effects 0.000 description 23
- 235000013601 eggs Nutrition 0.000 description 22
- 239000000463 material Substances 0.000 description 21
- 101710137500 T7 RNA polymerase Proteins 0.000 description 20
- 230000000694 effects Effects 0.000 description 20
- 230000015572 biosynthetic process Effects 0.000 description 19
- 239000013598 vector Substances 0.000 description 17
- 102000016928 DNA-directed DNA polymerase Human genes 0.000 description 16
- 108010014303 DNA-directed DNA polymerase Proteins 0.000 description 16
- 230000035931 haemagglutination Effects 0.000 description 15
- 239000002245 particle Substances 0.000 description 14
- 230000000405 serological effect Effects 0.000 description 13
- 102100038132 Endogenous retrovirus group K member 6 Pro protein Human genes 0.000 description 12
- 238000012163 sequencing technique Methods 0.000 description 12
- 125000003275 alpha amino acid group Chemical group 0.000 description 11
- 239000002609 medium Substances 0.000 description 11
- 238000010839 reverse transcription Methods 0.000 description 11
- 102000004594 DNA Polymerase I Human genes 0.000 description 10
- 108010017826 DNA Polymerase I Proteins 0.000 description 10
- 108091027544 Subgenomic mRNA Proteins 0.000 description 10
- 230000007918 pathogenicity Effects 0.000 description 10
- 239000000047 product Substances 0.000 description 10
- 230000002103 transcriptional effect Effects 0.000 description 10
- 108010042653 IgA receptor Proteins 0.000 description 9
- 102100034349 Integrase Human genes 0.000 description 9
- 102100034014 Prolyl 3-hydroxylase 3 Human genes 0.000 description 9
- 230000000890 antigenic effect Effects 0.000 description 9
- 229940031551 inactivated vaccine Drugs 0.000 description 9
- 208000024891 symptom Diseases 0.000 description 9
- 238000011282 treatment Methods 0.000 description 9
- 241000272517 Anseriformes Species 0.000 description 8
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- 101710085938 Matrix protein Proteins 0.000 description 8
- 101710127721 Membrane protein Proteins 0.000 description 8
- 108020000999 Viral RNA Proteins 0.000 description 8
- 238000011534 incubation Methods 0.000 description 8
- 210000002345 respiratory system Anatomy 0.000 description 8
- 102000040650 (ribonucleotides)n+m Human genes 0.000 description 7
- 108090000626 DNA-directed RNA polymerases Proteins 0.000 description 7
- 102000004163 DNA-directed RNA polymerases Human genes 0.000 description 7
- 101710204837 Envelope small membrane protein Proteins 0.000 description 7
- 101710177166 Phosphoprotein Proteins 0.000 description 7
- 101710086015 RNA ligase Proteins 0.000 description 7
- 108010092799 RNA-directed DNA polymerase Proteins 0.000 description 7
- 238000004458 analytical method Methods 0.000 description 7
- 230000000295 complement effect Effects 0.000 description 7
- 230000036039 immunity Effects 0.000 description 7
- 230000001965 increasing effect Effects 0.000 description 7
- 230000000241 respiratory effect Effects 0.000 description 7
- 230000004044 response Effects 0.000 description 7
- 102000053642 Catalytic RNA Human genes 0.000 description 6
- 108090000994 Catalytic RNA Proteins 0.000 description 6
- 108091035707 Consensus sequence Proteins 0.000 description 6
- 102000004127 Cytokines Human genes 0.000 description 6
- 108090000695 Cytokines Proteins 0.000 description 6
- 102000012410 DNA Ligases Human genes 0.000 description 6
- 108010061982 DNA Ligases Proteins 0.000 description 6
- 206010028980 Neoplasm Diseases 0.000 description 6
- 241000286209 Phasianidae Species 0.000 description 6
- 101710088839 Replication initiation protein Proteins 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- 238000011161 development Methods 0.000 description 6
- 238000002474 experimental method Methods 0.000 description 6
- 210000001035 gastrointestinal tract Anatomy 0.000 description 6
- 230000007246 mechanism Effects 0.000 description 6
- 108020004999 messenger RNA Proteins 0.000 description 6
- 238000004264 monolayer culture Methods 0.000 description 6
- 108091092562 ribozyme Proteins 0.000 description 6
- 239000006228 supernatant Substances 0.000 description 6
- 201000006082 Chickenpox Diseases 0.000 description 5
- 102000004190 Enzymes Human genes 0.000 description 5
- 108090000790 Enzymes Proteins 0.000 description 5
- 108091034117 Oligonucleotide Proteins 0.000 description 5
- 102000035195 Peptidases Human genes 0.000 description 5
- 108010008038 Synthetic Vaccines Proteins 0.000 description 5
- 206010046980 Varicella Diseases 0.000 description 5
- 238000013459 approach Methods 0.000 description 5
- 210000000170 cell membrane Anatomy 0.000 description 5
- 101150070926 ct gene Proteins 0.000 description 5
- 238000002405 diagnostic procedure Methods 0.000 description 5
- 210000003743 erythrocyte Anatomy 0.000 description 5
- 230000002068 genetic effect Effects 0.000 description 5
- 230000005847 immunogenicity Effects 0.000 description 5
- 239000010410 layer Substances 0.000 description 5
- 230000008774 maternal effect Effects 0.000 description 5
- 239000011541 reaction mixture Substances 0.000 description 5
- 229940124551 recombinant vaccine Drugs 0.000 description 5
- 210000002966 serum Anatomy 0.000 description 5
- 239000012134 supernatant fraction Substances 0.000 description 5
- 230000001629 suppression Effects 0.000 description 5
- 208000030507 AIDS Diseases 0.000 description 4
- 108091003079 Bovine Serum Albumin Proteins 0.000 description 4
- HEDRZPFGACZZDS-UHFFFAOYSA-N Chloroform Chemical compound ClC(Cl)Cl HEDRZPFGACZZDS-UHFFFAOYSA-N 0.000 description 4
- 241000272201 Columbiformes Species 0.000 description 4
- 241000701867 Enterobacteria phage T7 Species 0.000 description 4
- 108060003393 Granulin Proteins 0.000 description 4
- 241000725303 Human immunodeficiency virus Species 0.000 description 4
- 239000000443 aerosol Substances 0.000 description 4
- 239000003242 anti bacterial agent Substances 0.000 description 4
- 229940088710 antibiotic agent Drugs 0.000 description 4
- 230000002238 attenuated effect Effects 0.000 description 4
- 239000003153 chemical reaction reagent Substances 0.000 description 4
- WIIZWVCIJKGZOK-RKDXNWHRSA-N chloramphenicol Chemical compound ClC(Cl)C(=O)N[C@H](CO)[C@H](O)C1=CC=C([N+]([O-])=O)C=C1 WIIZWVCIJKGZOK-RKDXNWHRSA-N 0.000 description 4
- 230000001419 dependent effect Effects 0.000 description 4
- 230000004069 differentiation Effects 0.000 description 4
- 239000003651 drinking water Substances 0.000 description 4
- 235000020188 drinking water Nutrition 0.000 description 4
- 238000012239 gene modification Methods 0.000 description 4
- 230000005017 genetic modification Effects 0.000 description 4
- 235000013617 genetically modified food Nutrition 0.000 description 4
- 230000028993 immune response Effects 0.000 description 4
- 230000006698 induction Effects 0.000 description 4
- 239000012678 infectious agent Substances 0.000 description 4
- 238000011081 inoculation Methods 0.000 description 4
- 238000002955 isolation Methods 0.000 description 4
- 230000003472 neutralizing effect Effects 0.000 description 4
- 230000008569 process Effects 0.000 description 4
- 208000023504 respiratory system disease Diseases 0.000 description 4
- 238000012216 screening Methods 0.000 description 4
- 238000001228 spectrum Methods 0.000 description 4
- 238000003786 synthesis reaction Methods 0.000 description 4
- 210000002845 virion Anatomy 0.000 description 4
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 4
- 102000002260 Alkaline Phosphatase Human genes 0.000 description 3
- 108020004774 Alkaline Phosphatase Proteins 0.000 description 3
- 241000283690 Bos taurus Species 0.000 description 3
- 108020004705 Codon Proteins 0.000 description 3
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 3
- ROHFNLRQFUQHCH-YFKPBYRVSA-N L-leucine Chemical compound CC(C)C[C@H](N)C(O)=O ROHFNLRQFUQHCH-YFKPBYRVSA-N 0.000 description 3
- 241000711408 Murine respirovirus Species 0.000 description 3
- 206010035148 Plague Diseases 0.000 description 3
- 108700008625 Reporter Genes Proteins 0.000 description 3
- 241000607479 Yersinia pestis Species 0.000 description 3
- JLCPHMBAVCMARE-UHFFFAOYSA-N [3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[3-[[3-[[3-[[3-[[3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-[[5-(2-amino-6-oxo-1H-purin-9-yl)-3-hydroxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxyoxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(5-methyl-2,4-dioxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(6-aminopurin-9-yl)oxolan-2-yl]methoxy-hydroxyphosphoryl]oxy-5-(4-amino-2-oxopyrimidin-1-yl)oxolan-2-yl]methyl [5-(6-aminopurin-9-yl)-2-(hydroxymethyl)oxolan-3-yl] hydrogen phosphate Polymers Cc1cn(C2CC(OP(O)(=O)OCC3OC(CC3OP(O)(=O)OCC3OC(CC3O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c3nc(N)[nH]c4=O)C(COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3COP(O)(=O)OC3CC(OC3CO)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3ccc(N)nc3=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cc(C)c(=O)[nH]c3=O)n3cc(C)c(=O)[nH]c3=O)n3ccc(N)nc3=O)n3cc(C)c(=O)[nH]c3=O)n3cnc4c3nc(N)[nH]c4=O)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)n3cnc4c(N)ncnc34)O2)c(=O)[nH]c1=O JLCPHMBAVCMARE-UHFFFAOYSA-N 0.000 description 3
- 239000002671 adjuvant Substances 0.000 description 3
- 230000003321 amplification Effects 0.000 description 3
- 230000034303 cell budding Effects 0.000 description 3
- 229960005091 chloramphenicol Drugs 0.000 description 3
- 238000010276 construction Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 230000007423 decrease Effects 0.000 description 3
- 238000013461 design Methods 0.000 description 3
- 230000012010 growth Effects 0.000 description 3
- 230000001900 immune effect Effects 0.000 description 3
- 230000003993 interaction Effects 0.000 description 3
- 230000000968 intestinal effect Effects 0.000 description 3
- 229930027917 kanamycin Natural products 0.000 description 3
- 229960000318 kanamycin Drugs 0.000 description 3
- SBUJHOSQTJFQJX-NOAMYHISSA-N kanamycin Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CN)O[C@@H]1O[C@H]1[C@H](O)[C@@H](O[C@@H]2[C@@H]([C@@H](N)[C@H](O)[C@@H](CO)O2)O)[C@H](N)C[C@@H]1N SBUJHOSQTJFQJX-NOAMYHISSA-N 0.000 description 3
- 229930182823 kanamycin A Natural products 0.000 description 3
- 231100000518 lethal Toxicity 0.000 description 3
- 230000001665 lethal effect Effects 0.000 description 3
- 230000033001 locomotion Effects 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 210000004379 membrane Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 108091005573 modified proteins Proteins 0.000 description 3
- 102000035118 modified proteins Human genes 0.000 description 3
- 239000013642 negative control Substances 0.000 description 3
- 238000006386 neutralization reaction Methods 0.000 description 3
- 238000003199 nucleic acid amplification method Methods 0.000 description 3
- 230000036961 partial effect Effects 0.000 description 3
- 210000002381 plasma Anatomy 0.000 description 3
- 235000013613 poultry product Nutrition 0.000 description 3
- 108090000765 processed proteins & peptides Proteins 0.000 description 3
- 230000002441 reversible effect Effects 0.000 description 3
- 238000012552 review Methods 0.000 description 3
- 239000000243 solution Substances 0.000 description 3
- 210000001519 tissue Anatomy 0.000 description 3
- 230000009466 transformation Effects 0.000 description 3
- 238000013519 translation Methods 0.000 description 3
- 210000004881 tumor cell Anatomy 0.000 description 3
- 230000029812 viral genome replication Effects 0.000 description 3
- 101710169850 Catalase isozyme B Proteins 0.000 description 2
- 102100023336 Chymotrypsin-like elastase family member 3B Human genes 0.000 description 2
- 108020004635 Complementary DNA Proteins 0.000 description 2
- 239000003155 DNA primer Substances 0.000 description 2
- 239000006145 Eagle's minimal essential medium Substances 0.000 description 2
- WSFSSNUMVMOOMR-UHFFFAOYSA-N Formaldehyde Chemical compound O=C WSFSSNUMVMOOMR-UHFFFAOYSA-N 0.000 description 2
- 108090000288 Glycoproteins Proteins 0.000 description 2
- 102000003886 Glycoproteins Human genes 0.000 description 2
- 241000282412 Homo Species 0.000 description 2
- 101001072091 Homo sapiens ProSAAS Proteins 0.000 description 2
- 241000712003 Human respirovirus 3 Species 0.000 description 2
- 102000014150 Interferons Human genes 0.000 description 2
- 108010050904 Interferons Proteins 0.000 description 2
- COLNVLDHVKWLRT-QMMMGPOBSA-N L-phenylalanine Chemical compound OC(=O)[C@@H](N)CC1=CC=CC=C1 COLNVLDHVKWLRT-QMMMGPOBSA-N 0.000 description 2
- 208000006758 Marek Disease Diseases 0.000 description 2
- 241000712079 Measles morbillivirus Species 0.000 description 2
- 241000272458 Numididae Species 0.000 description 2
- 101150084044 P gene Proteins 0.000 description 2
- 208000027954 Poultry disease Diseases 0.000 description 2
- 102100036366 ProSAAS Human genes 0.000 description 2
- 241000287530 Psittaciformes Species 0.000 description 2
- 206010057190 Respiratory tract infections Diseases 0.000 description 2
- 210000001744 T-lymphocyte Anatomy 0.000 description 2
- 108010003533 Viral Envelope Proteins Proteins 0.000 description 2
- 230000010530 Virus Neutralization Effects 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- 230000001154 acute effect Effects 0.000 description 2
- 230000004520 agglutination Effects 0.000 description 2
- 230000005875 antibody response Effects 0.000 description 2
- 230000003115 biocidal effect Effects 0.000 description 2
- 230000008827 biological function Effects 0.000 description 2
- 230000005540 biological transmission Effects 0.000 description 2
- 229940098773 bovine serum albumin Drugs 0.000 description 2
- 210000004899 c-terminal region Anatomy 0.000 description 2
- 230000007910 cell fusion Effects 0.000 description 2
- 238000005119 centrifugation Methods 0.000 description 2
- 230000008859 change Effects 0.000 description 2
- 230000004186 co-expression Effects 0.000 description 2
- 210000000805 cytoplasm Anatomy 0.000 description 2
- 230000029087 digestion Effects 0.000 description 2
- 238000010790 dilution Methods 0.000 description 2
- 239000012895 dilution Substances 0.000 description 2
- 238000009826 distribution Methods 0.000 description 2
- 241001493065 dsRNA viruses Species 0.000 description 2
- 230000008029 eradication Effects 0.000 description 2
- 230000007717 exclusion Effects 0.000 description 2
- 230000001747 exhibiting effect Effects 0.000 description 2
- 239000012894 fetal calf serum Substances 0.000 description 2
- 238000011049 filling Methods 0.000 description 2
- 208000006454 hepatitis Diseases 0.000 description 2
- 230000003053 immunization Effects 0.000 description 2
- 238000002649 immunization Methods 0.000 description 2
- 230000002163 immunogen Effects 0.000 description 2
- 230000000977 initiatory effect Effects 0.000 description 2
- 238000002347 injection Methods 0.000 description 2
- 239000007924 injection Substances 0.000 description 2
- 230000037431 insertion Effects 0.000 description 2
- 238000003780 insertion Methods 0.000 description 2
- 229940047124 interferons Drugs 0.000 description 2
- 208000028774 intestinal disease Diseases 0.000 description 2
- 210000003734 kidney Anatomy 0.000 description 2
- 210000004185 liver Anatomy 0.000 description 2
- 238000012768 mass vaccination Methods 0.000 description 2
- 210000004779 membrane envelope Anatomy 0.000 description 2
- 231100000350 mutagenesis Toxicity 0.000 description 2
- 238000002703 mutagenesis Methods 0.000 description 2
- 230000035772 mutation Effects 0.000 description 2
- 108091027963 non-coding RNA Proteins 0.000 description 2
- 102000042567 non-coding RNA Human genes 0.000 description 2
- 210000000056 organ Anatomy 0.000 description 2
- 238000004806 packaging method and process Methods 0.000 description 2
- 230000035515 penetration Effects 0.000 description 2
- 230000004983 pleiotropic effect Effects 0.000 description 2
- 108010043524 protease E Proteins 0.000 description 2
- 230000001681 protective effect Effects 0.000 description 2
- 238000000746 purification Methods 0.000 description 2
- 238000004445 quantitative analysis Methods 0.000 description 2
- 230000009257 reactivity Effects 0.000 description 2
- 230000002829 reductive effect Effects 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 238000005507 spraying Methods 0.000 description 2
- UCSJYZPVAKXKNQ-HZYVHMACSA-N streptomycin Chemical compound CN[C@H]1[C@H](O)[C@@H](O)[C@H](CO)O[C@H]1O[C@@H]1[C@](C=O)(O)[C@H](C)O[C@H]1O[C@@H]1[C@@H](NC(N)=N)[C@H](O)[C@@H](NC(N)=N)[C@H](O)[C@H]1O UCSJYZPVAKXKNQ-HZYVHMACSA-N 0.000 description 2
- 230000009885 systemic effect Effects 0.000 description 2
- 230000001810 trypsinlike Effects 0.000 description 2
- 230000009385 viral infection Effects 0.000 description 2
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 229920001817 Agar Polymers 0.000 description 1
- 102220595000 Ankyrin repeat and SOCS box protein 8_H8R_mutation Human genes 0.000 description 1
- 235000005749 Anthriscus sylvestris Nutrition 0.000 description 1
- 101100499944 Arabidopsis thaliana POL2A gene Proteins 0.000 description 1
- BHELIUBJHYAEDK-OAIUPTLZSA-N Aspoxicillin Chemical compound C1([C@H](C(=O)N[C@@H]2C(N3[C@H](C(C)(C)S[C@@H]32)C(O)=O)=O)NC(=O)[C@H](N)CC(=O)NC)=CC=C(O)C=C1 BHELIUBJHYAEDK-OAIUPTLZSA-N 0.000 description 1
- 102100027708 Astrotactin-1 Human genes 0.000 description 1
- 241000714230 Avian leukemia virus Species 0.000 description 1
- 101150076489 B gene Proteins 0.000 description 1
- 101710151325 B2 protein Proteins 0.000 description 1
- 101000755953 Bacillus subtilis (strain 168) Ribosome maturation factor RimP Proteins 0.000 description 1
- 108700040077 Baculovirus p10 Proteins 0.000 description 1
- 102100021257 Beta-secretase 1 Human genes 0.000 description 1
- 101100245267 Caenorhabditis elegans pas-1 gene Proteins 0.000 description 1
- 101100298222 Caenorhabditis elegans pot-1 gene Proteins 0.000 description 1
- 241000282465 Canis Species 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 102000019034 Chemokines Human genes 0.000 description 1
- 108010012236 Chemokines Proteins 0.000 description 1
- 241000725585 Chicken anemia virus Species 0.000 description 1
- 208000001726 Classical Swine Fever Diseases 0.000 description 1
- 108091026890 Coding region Proteins 0.000 description 1
- 208000003322 Coinfection Diseases 0.000 description 1
- 241001275954 Cortinarius caperatus Species 0.000 description 1
- 102000053602 DNA Human genes 0.000 description 1
- 229920002307 Dextran Polymers 0.000 description 1
- 101100291267 Drosophila melanogaster Miga gene Proteins 0.000 description 1
- 101100369915 Drosophila melanogaster stas gene Proteins 0.000 description 1
- KCXVZYZYPLLWCC-UHFFFAOYSA-N EDTA Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(O)=O)CC(O)=O KCXVZYZYPLLWCC-UHFFFAOYSA-N 0.000 description 1
- 108010067770 Endopeptidase K Proteins 0.000 description 1
- 102000009025 Endorphins Human genes 0.000 description 1
- 108010049140 Endorphins Proteins 0.000 description 1
- 101710121417 Envelope glycoprotein Proteins 0.000 description 1
- 101710091045 Envelope protein Proteins 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000701533 Escherichia virus T4 Species 0.000 description 1
- UOACKFBJUYNSLK-XRKIENNPSA-N Estradiol Cypionate Chemical compound O([C@H]1CC[C@H]2[C@H]3[C@@H](C4=CC=C(O)C=C4CC3)CC[C@@]21C)C(=O)CCC1CCCC1 UOACKFBJUYNSLK-XRKIENNPSA-N 0.000 description 1
- 241000701063 Gallid alphaherpesvirus 1 Species 0.000 description 1
- 241000701047 Gallid alphaherpesvirus 2 Species 0.000 description 1
- -1 H8P Proteins 0.000 description 1
- 101710154606 Hemagglutinin Proteins 0.000 description 1
- 208000032843 Hemorrhage Diseases 0.000 description 1
- 241000709721 Hepatovirus A Species 0.000 description 1
- 102100039121 Histone-lysine N-methyltransferase MECOM Human genes 0.000 description 1
- 101000936741 Homo sapiens Astrotactin-1 Proteins 0.000 description 1
- 101000894895 Homo sapiens Beta-secretase 1 Proteins 0.000 description 1
- 101001033728 Homo sapiens Histone-lysine N-methyltransferase MECOM Proteins 0.000 description 1
- 101001103034 Homo sapiens Nuclear receptor ROR-beta Proteins 0.000 description 1
- 241000701024 Human betaherpesvirus 5 Species 0.000 description 1
- 241000711920 Human orthopneumovirus Species 0.000 description 1
- 241000711450 Infectious bronchitis virus Species 0.000 description 1
- 101710125507 Integrase/recombinase Proteins 0.000 description 1
- 108091026898 Leader sequence (mRNA) Proteins 0.000 description 1
- ROHFNLRQFUQHCH-UHFFFAOYSA-N Leucine Natural products CC(C)CC(N)C(O)=O ROHFNLRQFUQHCH-UHFFFAOYSA-N 0.000 description 1
- 101710145006 Lysis protein Proteins 0.000 description 1
- 108700018351 Major Histocompatibility Complex Proteins 0.000 description 1
- 241001502481 Meleagrid alphaherpesvirus 1 Species 0.000 description 1
- 241000711386 Mumps virus Species 0.000 description 1
- 241000699660 Mus musculus Species 0.000 description 1
- 241000699670 Mus sp. Species 0.000 description 1
- 102000005348 Neuraminidase Human genes 0.000 description 1
- 108010006232 Neuraminidase Proteins 0.000 description 1
- 206010060860 Neurological symptom Diseases 0.000 description 1
- 108091092724 Noncoding DNA Proteins 0.000 description 1
- 102100039617 Nuclear receptor ROR-beta Human genes 0.000 description 1
- 108010061100 Nucleoproteins Proteins 0.000 description 1
- 102000011931 Nucleoproteins Human genes 0.000 description 1
- 241000337007 Oceania Species 0.000 description 1
- 241000702244 Orthoreovirus Species 0.000 description 1
- 101710093908 Outer capsid protein VP4 Proteins 0.000 description 1
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 description 1
- 102100034574 P protein Human genes 0.000 description 1
- 101710181008 P protein Proteins 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 208000002606 Paramyxoviridae Infections Diseases 0.000 description 1
- 229930182555 Penicillin Natural products 0.000 description 1
- JGSARLDLIJGVTE-MBNYWOFBSA-N Penicillin G Chemical compound N([C@H]1[C@H]2SC([C@@H](N2C1=O)C(O)=O)(C)C)C(=O)CC1=CC=CC=C1 JGSARLDLIJGVTE-MBNYWOFBSA-N 0.000 description 1
- ISWSIDIOOBJBQZ-UHFFFAOYSA-N Phenol Chemical compound OC1=CC=CC=C1 ISWSIDIOOBJBQZ-UHFFFAOYSA-N 0.000 description 1
- 102000004160 Phosphoric Monoester Hydrolases Human genes 0.000 description 1
- 108090000608 Phosphoric Monoester Hydrolases Proteins 0.000 description 1
- 241000711902 Pneumovirus Species 0.000 description 1
- 239000004698 Polyethylene Substances 0.000 description 1
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 108010093965 Polymyxin B Proteins 0.000 description 1
- 108010021757 Polynucleotide 5'-Hydroxyl-Kinase Proteins 0.000 description 1
- 102000008422 Polynucleotide 5'-hydroxyl-kinase Human genes 0.000 description 1
- 101710176177 Protein A56 Proteins 0.000 description 1
- 101710188315 Protein X Proteins 0.000 description 1
- 101710185720 Putative ethidium bromide resistance protein Proteins 0.000 description 1
- 238000010357 RNA editing Methods 0.000 description 1
- 230000026279 RNA modification Effects 0.000 description 1
- 241000711798 Rabies lyssavirus Species 0.000 description 1
- 108020004511 Recombinant DNA Proteins 0.000 description 1
- 208000035415 Reinfection Diseases 0.000 description 1
- 241000923660 Rorippa sylvestris Species 0.000 description 1
- 108091006597 SLC15A4 Proteins 0.000 description 1
- 241000607142 Salmonella Species 0.000 description 1
- 241000566587 Sayornis Species 0.000 description 1
- 241000801924 Sena Species 0.000 description 1
- 108020004682 Single-Stranded DNA Proteins 0.000 description 1
- 102100021484 Solute carrier family 15 member 4 Human genes 0.000 description 1
- 108091081024 Start codon Proteins 0.000 description 1
- 241000271567 Struthioniformes Species 0.000 description 1
- 108091008874 T cell receptors Proteins 0.000 description 1
- 230000005867 T cell response Effects 0.000 description 1
- 102000016266 T-Cell Antigen Receptors Human genes 0.000 description 1
- 241001125929 Trisopterus luscus Species 0.000 description 1
- 108090000631 Trypsin Proteins 0.000 description 1
- 102000004142 Trypsin Human genes 0.000 description 1
- 241000711955 Turkey rhinotracheitis virus Species 0.000 description 1
- 241000711975 Vesicular stomatitis virus Species 0.000 description 1
- 206010058874 Viraemia Diseases 0.000 description 1
- 208000036142 Viral infection Diseases 0.000 description 1
- 238000009825 accumulation Methods 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 239000008272 agar Substances 0.000 description 1
- 239000011543 agarose gel Substances 0.000 description 1
- 230000002776 aggregation Effects 0.000 description 1
- 238000004220 aggregation Methods 0.000 description 1
- 210000001643 allantois Anatomy 0.000 description 1
- 125000000539 amino acid group Chemical group 0.000 description 1
- APKFDSVGJQXUKY-INPOYWNPSA-N amphotericin B Chemical compound O[C@H]1[C@@H](N)[C@H](O)[C@@H](C)O[C@H]1O[C@H]1/C=C/C=C/C=C/C=C/C=C/C=C/C=C/[C@H](C)[C@@H](O)[C@@H](C)[C@H](C)OC(=O)C[C@H](O)C[C@H](O)CC[C@@H](O)[C@H](O)C[C@H](O)C[C@](O)(C[C@H](O)[C@H]2C(O)=O)O[C@H]2C1 APKFDSVGJQXUKY-INPOYWNPSA-N 0.000 description 1
- 230000000259 anti-tumor effect Effects 0.000 description 1
- 101150099047 apip gene Proteins 0.000 description 1
- 239000012223 aqueous fraction Substances 0.000 description 1
- 125000000637 arginyl group Chemical group N[C@@H](CCCNC(N)=N)C(=O)* 0.000 description 1
- 230000000386 athletic effect Effects 0.000 description 1
- 229940031567 attenuated vaccine Drugs 0.000 description 1
- 229940037642 autologous vaccine Drugs 0.000 description 1
- VEZXCJBBBCKRPI-UHFFFAOYSA-N beta-propiolactone Chemical compound O=C1CCO1 VEZXCJBBBCKRPI-UHFFFAOYSA-N 0.000 description 1
- 230000036782 biological activation Effects 0.000 description 1
- 238000010170 biological method Methods 0.000 description 1
- 230000000903 blocking effect Effects 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 238000009395 breeding Methods 0.000 description 1
- 230000001488 breeding effect Effects 0.000 description 1
- 244000309466 calf Species 0.000 description 1
- 210000000234 capsid Anatomy 0.000 description 1
- 210000005056 cell body Anatomy 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000032823 cell division Effects 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 210000003169 central nervous system Anatomy 0.000 description 1
- 238000012512 characterization method Methods 0.000 description 1
- 230000001886 ciliary effect Effects 0.000 description 1
- 229910017052 cobalt Inorganic materials 0.000 description 1
- 239000010941 cobalt Substances 0.000 description 1
- GUTLYIVDDKVIGB-UHFFFAOYSA-N cobalt atom Chemical compound [Co] GUTLYIVDDKVIGB-UHFFFAOYSA-N 0.000 description 1
- 238000010835 comparative analysis Methods 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000036461 convulsion Effects 0.000 description 1
- 239000012228 culture supernatant Substances 0.000 description 1
- 210000004748 cultured cell Anatomy 0.000 description 1
- 238000012258 culturing Methods 0.000 description 1
- 210000001151 cytotoxic T lymphocyte Anatomy 0.000 description 1
- 230000002498 deadly effect Effects 0.000 description 1
- 230000034994 death Effects 0.000 description 1
- 230000003111 delayed effect Effects 0.000 description 1
- 239000005547 deoxyribonucleotide Substances 0.000 description 1
- 125000002637 deoxyribonucleotide group Chemical group 0.000 description 1
- FFYPMLJYZAEMQB-UHFFFAOYSA-N diethyl pyrocarbonate Chemical compound CCOC(=O)OC(=O)OCC FFYPMLJYZAEMQB-UHFFFAOYSA-N 0.000 description 1
- VHJLVAABSRFDPM-QWWZWVQMSA-N dithiothreitol Chemical compound SC[C@@H](O)[C@H](O)CS VHJLVAABSRFDPM-QWWZWVQMSA-N 0.000 description 1
- 238000001962 electrophoresis Methods 0.000 description 1
- 210000002257 embryonic structure Anatomy 0.000 description 1
- 239000000839 emulsion Substances 0.000 description 1
- 230000007613 environmental effect Effects 0.000 description 1
- 210000000981 epithelium Anatomy 0.000 description 1
- 239000013604 expression vector Substances 0.000 description 1
- 238000000605 extraction Methods 0.000 description 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 239000012737 fresh medium Substances 0.000 description 1
- 230000006870 function Effects 0.000 description 1
- 239000011521 glass Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 239000000185 hemagglutinin Substances 0.000 description 1
- 235000010299 hexamethylene tetramine Nutrition 0.000 description 1
- 239000004312 hexamethylene tetramine Substances 0.000 description 1
- VKYKSIONXSXAKP-UHFFFAOYSA-N hexamethylenetetramine Chemical compound C1N(C2)CN3CN1CN2C3 VKYKSIONXSXAKP-UHFFFAOYSA-N 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000028996 humoral immune response Effects 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 238000005286 illumination Methods 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 239000012535 impurity Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 239000002054 inoculum Substances 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 238000007918 intramuscular administration Methods 0.000 description 1
- 238000001990 intravenous administration Methods 0.000 description 1
- 230000002147 killing effect Effects 0.000 description 1
- 230000000670 limiting effect Effects 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 210000004072 lung Anatomy 0.000 description 1
- 239000006166 lysate Substances 0.000 description 1
- 210000001161 mammalian embryo Anatomy 0.000 description 1
- 230000000873 masking effect Effects 0.000 description 1
- 235000013372 meat Nutrition 0.000 description 1
- 230000001617 migratory effect Effects 0.000 description 1
- 238000002715 modification method Methods 0.000 description 1
- 210000004400 mucous membrane Anatomy 0.000 description 1
- 231100000219 mutagenic Toxicity 0.000 description 1
- 230000003505 mutagenic effect Effects 0.000 description 1
- 210000000653 nervous system Anatomy 0.000 description 1
- 230000002276 neurotropic effect Effects 0.000 description 1
- 238000011580 nude mouse model Methods 0.000 description 1
- 229960005030 other vaccine in atc Drugs 0.000 description 1
- 230000000803 paradoxical effect Effects 0.000 description 1
- 108700010867 paramyxovirus proteins Proteins 0.000 description 1
- 239000008188 pellet Substances 0.000 description 1
- 229940049954 penicillin Drugs 0.000 description 1
- COLNVLDHVKWLRT-UHFFFAOYSA-N phenylalanine Natural products OC(=O)C(N)CC1=CC=CC=C1 COLNVLDHVKWLRT-UHFFFAOYSA-N 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000004033 plastic Substances 0.000 description 1
- 229920003023 plastic Polymers 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 229920000024 polymyxin B Polymers 0.000 description 1
- 229960005266 polymyxin b Drugs 0.000 description 1
- 230000001323 posttranslational effect Effects 0.000 description 1
- 230000003389 potentiating effect Effects 0.000 description 1
- 239000002244 precipitate Substances 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000003449 preventive effect Effects 0.000 description 1
- 102000004196 processed proteins & peptides Human genes 0.000 description 1
- 229960000380 propiolactone Drugs 0.000 description 1
- 230000007026 protein scission Effects 0.000 description 1
- 230000012743 protein tagging Effects 0.000 description 1
- 230000006337 proteolytic cleavage Effects 0.000 description 1
- 108020003175 receptors Proteins 0.000 description 1
- 102000005962 receptors Human genes 0.000 description 1
- 238000010188 recombinant method Methods 0.000 description 1
- 230000000306 recurrent effect Effects 0.000 description 1
- 230000033458 reproduction Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 102220277134 rs776745497 Human genes 0.000 description 1
- 230000035945 sensitivity Effects 0.000 description 1
- 230000009919 sequestration Effects 0.000 description 1
- 239000002356 single layer Substances 0.000 description 1
- 238000001179 sorption measurement Methods 0.000 description 1
- 210000000952 spleen Anatomy 0.000 description 1
- 230000007480 spreading Effects 0.000 description 1
- 238000003892 spreading Methods 0.000 description 1
- 238000003153 stable transfection Methods 0.000 description 1
- 238000010186 staining Methods 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 238000003756 stirring Methods 0.000 description 1
- 229960005322 streptomycin Drugs 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 208000032577 susceptibility to 3 autoimmune disease Diseases 0.000 description 1
- 208000036259 susceptibility to 4 autoimmune disease Diseases 0.000 description 1
- 239000000725 suspension Substances 0.000 description 1
- 201000004595 synovitis Diseases 0.000 description 1
- 230000009897 systematic effect Effects 0.000 description 1
- KBUCHHVKVMTLIG-UCGGBYDDSA-N tert-butyl (2S,4S)-4-dicyclohexylphosphanyl-2-(dicyclohexylphosphanylmethyl)pyrrolidine-1-carboxylate Chemical compound CC(C)(C)OC(=O)N1C[C@H](C[C@H]1CP(C1CCCCC1)C1CCCCC1)P(C1CCCCC1)C1CCCCC1 KBUCHHVKVMTLIG-UCGGBYDDSA-N 0.000 description 1
- 238000002560 therapeutic procedure Methods 0.000 description 1
- 231100000331 toxic Toxicity 0.000 description 1
- 230000002588 toxic effect Effects 0.000 description 1
- 210000003437 trachea Anatomy 0.000 description 1
- 230000005030 transcription termination Effects 0.000 description 1
- 238000012546 transfer Methods 0.000 description 1
- 230000010415 tropism Effects 0.000 description 1
- 239000012588 trypsin Substances 0.000 description 1
- 241000701161 unidentified adenovirus Species 0.000 description 1
- 241000701447 unidentified baculovirus Species 0.000 description 1
- 241000712461 unidentified influenza virus Species 0.000 description 1
- 229960004854 viral vaccine Drugs 0.000 description 1
- 230000003253 viricidal effect Effects 0.000 description 1
- 239000000304 virulence factor Substances 0.000 description 1
- 230000007923 virulence factor Effects 0.000 description 1
- 230000000007 visual effect Effects 0.000 description 1
- 238000003911 water pollution Methods 0.000 description 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
- Biophysics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Public Health (AREA)
- General Chemical & Material Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
- Plant Pathology (AREA)
- Physics & Mathematics (AREA)
- Microbiology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202054A EP0974660A1 (en) | 1998-06-19 | 1998-06-19 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| PCT/NL1999/000377 WO1999066045A1 (en) | 1998-06-19 | 1999-06-17 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| EA200100057A1 EA200100057A1 (ru) | 2001-08-27 |
| EA004796B1 true EA004796B1 (ru) | 2004-08-26 |
Family
ID=8233832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| EA200100057A EA004796B1 (ru) | 1998-06-19 | 1999-06-17 | Инфекционные клоны вируса ньюкаслской болезни, вакцины и диагностические анализы |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US6719979B2 (enExample) |
| EP (2) | EP0974660A1 (enExample) |
| JP (3) | JP2002518012A (enExample) |
| KR (1) | KR20010053000A (enExample) |
| CN (2) | CN101275142A (enExample) |
| AR (1) | AR020091A1 (enExample) |
| AT (1) | ATE367442T1 (enExample) |
| AU (1) | AU754844B2 (enExample) |
| BR (1) | BR9911383A (enExample) |
| CA (1) | CA2334165A1 (enExample) |
| CZ (1) | CZ300760B6 (enExample) |
| DE (1) | DE69936585T2 (enExample) |
| DK (1) | DK1088077T3 (enExample) |
| EA (1) | EA004796B1 (enExample) |
| ES (1) | ES2291029T3 (enExample) |
| HR (1) | HRP20010042B1 (enExample) |
| HU (1) | HUP0102429A3 (enExample) |
| ID (1) | ID27343A (enExample) |
| IL (2) | IL140381A0 (enExample) |
| NO (1) | NO329193B1 (enExample) |
| NZ (1) | NZ508982A (enExample) |
| PL (1) | PL197722B1 (enExample) |
| PT (1) | PT1088077E (enExample) |
| SI (1) | SI1088077T1 (enExample) |
| TR (1) | TR200100350T2 (enExample) |
| UA (1) | UA77146C2 (enExample) |
| WO (1) | WO1999066045A1 (enExample) |
| ZA (1) | ZA200100241B (enExample) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US10383936B2 (en) * | 1999-05-05 | 2019-08-20 | University Of Maryland, College Park | Infectious laryngotracheitis virus (ILTV) vaccine using recombinant newcastle disease virus vector |
| US7244558B1 (en) * | 1999-05-05 | 2007-07-17 | University Of Maryland | Production of novel Newcastle disease virus strains from cDNAs and improved live attenuated Newcastle disease vaccines |
| EP1074614B1 (en) * | 1999-07-27 | 2004-07-07 | Akzo Nobel N.V. | A recombinant Newcastle disease virus for in ovo vaccination |
| CA2312626A1 (en) | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
| ATE437223T1 (de) * | 2000-06-23 | 2009-08-15 | Intervet Int Bv | Attenuiertes bovines respiratorisches syncytialvirus |
| ATE352557T1 (de) | 2000-11-02 | 2007-02-15 | Intervet Int Bv | Rekombinantes nukleoprotein von newcastle- krankheitsvirus als markierungsimpfstoff |
| KR100437888B1 (ko) * | 2001-07-30 | 2004-07-03 | 주식회사 인트론바이오테크놀로지 | 뉴캐슬병 바이러스 검출용 프라이머 및 상기 프라이머를이용한 뉴캐슬병 바이러스 검출, 병원성 및 유전형 조사방법 |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| DE60114420T2 (de) * | 2001-10-04 | 2006-07-13 | Centrum Voor Onderzoek In Diergeneeskunde En Agrochemie | Abgeschwächter Mutantenstamm eines Virus der Newcastle-Krankheit für eine in Ovo Impfung und dessen Benutzung |
| JP2005518209A (ja) * | 2002-02-21 | 2005-06-23 | マウント シナイ スクール オブ メディシン | 組換えマイナス鎖ウイルスrna発現系およびワクチン |
| TW200502402A (en) * | 2002-12-06 | 2005-01-16 | Wyeth Corp | Escape mutants of newcastle disease virus as marker vaccines |
| US7132291B2 (en) | 2003-05-05 | 2006-11-07 | Dow Agro Sciences Llc | Vectors and cells for preparing immunoprotective compositions derived from transgenic plants |
| AU2004235800B2 (en) * | 2003-05-05 | 2010-02-18 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| CA2503774C (en) | 2003-06-20 | 2007-09-25 | Microbix Biosystems Inc. | Improvements in virus production |
| US7527638B2 (en) | 2003-12-16 | 2009-05-05 | Depuy Spine, Inc. | Methods and devices for minimally invasive spinal fixation element placement |
| MY146476A (en) | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
| GB0423681D0 (en) * | 2004-10-26 | 2004-11-24 | Sec Dep For Environment Food & | Vaccine and nucleic acids |
| JP2008519590A (ja) | 2004-11-12 | 2008-06-12 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 組換えニューカッスル病ウィルス |
| US7871626B2 (en) * | 2005-08-04 | 2011-01-18 | St. Jude Children's Research Hospital | Modified influenza virus for monitoring and improving vaccine efficiency |
| US9216212B2 (en) | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EA016217B1 (ru) | 2005-12-02 | 2012-03-30 | Маунт Синай Скул Оф Медсин | Химерные вирусы, представляющие неприродные поверхностные белки, и их применение |
| KR20090007706A (ko) * | 2006-03-15 | 2009-01-20 | 인터벳 인터내셔널 비.브이. | 조류 인플루엔자 바이러스의 h5 헤마글루티닌을 발현하는 재조합 뉴캐슬병 바이러스 |
| AU2007226555B2 (en) * | 2006-03-15 | 2012-07-05 | Intervet International B.V. | Recombinant Mononegaviral virus vectors |
| KR100776398B1 (ko) * | 2006-03-23 | 2007-11-28 | 주식회사 고려비엔피 | 조류 hn 단백질의 에피토프 및 상기 변이 에피토프를포함하는 뉴캐슬병 바이러스 |
| KR100801180B1 (ko) | 2006-09-26 | 2008-02-05 | 주식회사 고려비엔피 | 약독화된 재조합 뉴캐슬병 바이러스 및 이를 함유하는뉴캐슬병 백신 |
| KR100874256B1 (ko) | 2007-02-12 | 2008-12-16 | 대한민국 | 대장균 내독소 단백질 및 뉴캐슬병 바이러스뉴라미니데이즈 에피토프의 융합단백질 및 이의 용도 |
| KR100955502B1 (ko) * | 2007-11-30 | 2010-04-30 | 대한민국 | 병원성 뉴캐슬병 바이러스 항체와 특이적으로 반응하는펩타이드 및 그의 용도 |
| EP2085092A1 (en) | 2008-01-29 | 2009-08-05 | Bayer Schering Pharma Aktiengesellschaft | Attenuated oncolytic paramyxoviruses encoding avian cytokines |
| US7794714B2 (en) * | 2008-03-14 | 2010-09-14 | The United States Of America As Represented By The Secretary Of Agriculture | Newcastle disease virus monoclonal antibodies |
| US20090258035A1 (en) * | 2008-03-21 | 2009-10-15 | The United States Of America, As Represented By The Secretary Of Agriculture | Avian virus vaccines and uses thereof |
| AU2008364200B2 (en) * | 2008-11-19 | 2016-01-28 | Laboratorio Avi-Mex, S.A. De C.V. | Recombinant inactivated viral vector vaccine |
| EP2987856B1 (en) | 2009-02-05 | 2018-07-25 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses and uses thereof |
| MX2012002114A (es) | 2009-08-21 | 2012-08-08 | Univ Georgia | Vacuna de paramixovirus aviar recombinante y metodo para hacerla y usarla. |
| US20110110975A1 (en) * | 2009-11-06 | 2011-05-12 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| ES2380289T3 (es) | 2009-11-30 | 2012-05-10 | United Cancer Research Institute | Nuevo clon del virus de la enfermedad de Newcastle, su fabricación y aplicación en el tratamiento médico del cáncer |
| US9956281B2 (en) | 2011-05-04 | 2018-05-01 | Streck, Inc. | Inactivated virus compositions and methods of preparing such compositions |
| JP6293664B2 (ja) | 2011-10-27 | 2018-03-14 | ウェルスタット オフサルミクス コーポレイション | 桿体由来錐体生存因子をコードするベクター |
| WO2013082327A1 (en) | 2011-11-30 | 2013-06-06 | Merial Limited | Recombinant hvt vectors expressing antigens of avian pathogens and uses thereof |
| KR101374192B1 (ko) * | 2011-12-21 | 2014-03-14 | 대한민국 | 제4형 조류파라믹소바이러스 hn 단백질 및 이를 포함하는 hi법 검사용 항원진단액 |
| WO2014158811A1 (en) | 2013-03-14 | 2014-10-02 | Icahn School Of Medicine At Mount Sinai | Newcastle disease viruses and uses thereof |
| CN104059942B (zh) * | 2013-03-20 | 2016-12-28 | 湖北省农业科学院畜牧兽医研究所 | 新城疫病毒耐热活疫苗载体系统及其应用 |
| US20140341950A1 (en) * | 2013-05-15 | 2014-11-20 | University Of Georgia Research Foundation, Inc. | Recombinant avian paramyxovirus vaccine and method for making and using thereof |
| SG11201607130RA (en) | 2014-02-27 | 2016-09-29 | Viralytics Ltd | Combination method for treatment of cancer |
| US10780158B2 (en) | 2015-11-16 | 2020-09-22 | Georgia State University Research Foundation, Inc. | Tunable vaccine platform against pathogens of the paramyxovirus family |
| RU2769406C2 (ru) | 2016-02-03 | 2022-03-31 | СиДжи ДИСКАВЕРИ, ИНК. | Композиции гемагглютинина гриппа с гетерологичными эпитопами и/или измененными сайтами расщепления при созревании |
| US10063211B2 (en) * | 2016-02-03 | 2018-08-28 | Qualcomm Incorporated | Compact bypass and decoupling structure for millimeter-wave circuits |
| US10196616B2 (en) | 2017-02-15 | 2019-02-05 | The United States Of America, As Represented By The Secretary Of Agriculture | Altered avian virus for in-ovo inoculation and methods of use thereof |
| JOP20190256A1 (ar) | 2017-05-12 | 2019-10-28 | Icahn School Med Mount Sinai | فيروسات داء نيوكاسل واستخداماتها |
| MX2020008988A (es) * | 2018-02-28 | 2020-09-28 | Regeneron Pharma | Sistemas y metodos para la identificacion de contaminantes virales. |
| WO2020014591A1 (en) * | 2018-07-13 | 2020-01-16 | Icahn School Of Medicine At Mount Sinai | Apmv and uses thereof for the treatment of cancer |
| US12391957B2 (en) | 2018-08-17 | 2025-08-19 | Icahn School Of Medicine At Mount Sinai | Recombinant Newcastle disease viruses and uses thereof for the prevention of RSV disease or human metapneumovirus disease |
| CN109735552A (zh) * | 2019-02-27 | 2019-05-10 | 苏州世诺生物技术有限公司 | 禽新城疫病毒新型基因工程亚单位疫苗 |
| CN110018304A (zh) * | 2019-05-15 | 2019-07-16 | 河南省农业科学院 | 一种新城疫抗体阻断检测试纸 |
| CN110240635B (zh) * | 2019-06-10 | 2022-04-22 | 华中农业大学 | 检测新城疫病毒抗体的多肽及其elisa检测试剂盒 |
| CN110257562A (zh) * | 2019-07-31 | 2019-09-20 | 河北农业大学 | 一种raa-lfd检测鸡传染性喉气管炎病毒的引物和探针组合及其应用 |
| US11334671B2 (en) * | 2019-10-14 | 2022-05-17 | International Business Machines Corporation | Adding adversarial robustness to trained machine learning models |
| KR102154796B1 (ko) * | 2019-10-18 | 2020-09-22 | 주식회사 바이오포아 | 변이 뉴캣슬병 바이러스 및 상기 바이러스를 이용한 조류 백신 |
| CN110938711A (zh) * | 2019-12-20 | 2020-03-31 | 河北农业大学 | 一种检测鸡传染性喉气管炎病毒的实时荧光raa引物和探针、试剂盒及其使用方法 |
| CN111334528B (zh) * | 2020-03-20 | 2022-02-18 | 山东农业大学 | 水貂肠炎细小病毒全基因组感染性克隆及其构建方法和应用 |
| CN112048484A (zh) * | 2020-07-27 | 2020-12-08 | 华南农业大学 | 一株表达传染性法氏囊强毒株vp2蛋白的基因ⅶ型新城疫重组病毒和疫苗 |
| CN114214338B (zh) * | 2021-08-26 | 2023-02-03 | 扬州大学 | 猪源piv5全长感染性克隆及其制备方法和应用 |
| WO2024206928A1 (en) | 2023-03-30 | 2024-10-03 | Pharma Cinq, Llc | VECTOR ENCODING ROD-DERIVED CONE VIABILITY FACTOR AND HUMAN IgK SIGNAL SEQUENCE |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| ATE257175T1 (de) | 1994-07-18 | 2004-01-15 | Conzelmann Karl Klaus Prof Dr | Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus |
| EP0832197A4 (en) * | 1995-06-07 | 2002-10-16 | Syntro Corp | RECOMBINANT AVIAN SMALLPOX VIRUS AND USES THEREOF |
| ATE181112T1 (de) * | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
-
1998
- 1998-06-19 EP EP98202054A patent/EP0974660A1/en not_active Withdrawn
-
1999
- 1999-06-17 IL IL14038199A patent/IL140381A0/xx active IP Right Grant
- 1999-06-17 UA UA2001010408A patent/UA77146C2/uk unknown
- 1999-06-17 CN CNA2008100921449A patent/CN101275142A/zh active Pending
- 1999-06-17 DK DK99926984T patent/DK1088077T3/da active
- 1999-06-17 EP EP99926984A patent/EP1088077B2/en not_active Expired - Lifetime
- 1999-06-17 CN CN99809714A patent/CN1314942A/zh active Pending
- 1999-06-17 HR HR20010042A patent/HRP20010042B1/xx not_active IP Right Cessation
- 1999-06-17 CZ CZ20004707A patent/CZ300760B6/cs not_active IP Right Cessation
- 1999-06-17 HU HU0102429A patent/HUP0102429A3/hu unknown
- 1999-06-17 JP JP2000554854A patent/JP2002518012A/ja not_active Withdrawn
- 1999-06-17 EA EA200100057A patent/EA004796B1/ru not_active IP Right Cessation
- 1999-06-17 PL PL348300A patent/PL197722B1/pl not_active IP Right Cessation
- 1999-06-17 AT AT99926984T patent/ATE367442T1/de active
- 1999-06-17 NZ NZ508982A patent/NZ508982A/en unknown
- 1999-06-17 WO PCT/NL1999/000377 patent/WO1999066045A1/en not_active Ceased
- 1999-06-17 SI SI9930990T patent/SI1088077T1/sl unknown
- 1999-06-17 PT PT99926984T patent/PT1088077E/pt unknown
- 1999-06-17 ID IDW20010146A patent/ID27343A/id unknown
- 1999-06-17 AU AU43991/99A patent/AU754844B2/en not_active Ceased
- 1999-06-17 KR KR1020007014397A patent/KR20010053000A/ko not_active Ceased
- 1999-06-17 TR TR2001/00350T patent/TR200100350T2/xx unknown
- 1999-06-17 BR BR9911383-0A patent/BR9911383A/pt not_active IP Right Cessation
- 1999-06-17 CA CA002334165A patent/CA2334165A1/en not_active Abandoned
- 1999-06-17 DE DE69936585T patent/DE69936585T2/de not_active Expired - Lifetime
- 1999-06-17 ES ES99926984T patent/ES2291029T3/es not_active Expired - Lifetime
- 1999-06-18 AR ARP990102948A patent/AR020091A1/es not_active Application Discontinuation
-
2000
- 2000-12-15 NO NO20006406A patent/NO329193B1/no not_active IP Right Cessation
- 2000-12-18 IL IL140381A patent/IL140381A/en not_active IP Right Cessation
- 2000-12-19 US US09/741,744 patent/US6719979B2/en not_active Expired - Fee Related
-
2001
- 2001-01-09 ZA ZA2001/00241A patent/ZA200100241B/en unknown
-
2004
- 2004-02-26 US US10/788,232 patent/US7332169B2/en not_active Expired - Fee Related
- 2004-04-15 US US10/824,782 patent/US7547442B2/en not_active Expired - Fee Related
-
2005
- 2005-12-01 JP JP2005347888A patent/JP2006141398A/ja active Pending
-
2009
- 2009-02-04 JP JP2009023349A patent/JP2009261387A/ja active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| EA004796B1 (ru) | Инфекционные клоны вируса ньюкаслской болезни, вакцины и диагностические анализы | |
| KR100992235B1 (ko) | 재조합 뉴캐슬 질병 바이러스 rna 발현계 및 백신 | |
| RU2766003C2 (ru) | Мультивалентные рекомбинантные вирусы птичьего герпеса и вакцины для иммунизации птиц | |
| JP4704232B2 (ja) | 組換え伝染性非セグメント化陰性鎖rnaウイルス | |
| US5187087A (en) | Recominbant herpesvirus of turkeys and live vector vaccines derived thereof | |
| KR20100108356A (ko) | 레오바이러스과 바이러스의 백신용 바이러스 균주를 제조하는 방법 | |
| EP3250234B1 (en) | Recombinant mdv1 and the uses thereof | |
| JPH11507241A (ja) | 組換え鶏痘ウイルスおよびその使用 | |
| JP3926887B2 (ja) | 多分子発現カセット及びその利用 | |
| MXPA00012787A (en) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): AM AZ KZ KG MD TJ TM |
|
| PC4A | Registration of transfer of a eurasian patent by assignment | ||
| MM4A | Lapse of a eurasian patent due to non-payment of renewal fees within the time limit in the following designated state(s) |
Designated state(s): BY RU |