AR020091A1 - Adnc de paramyxovirus aviar (particularmente virus de la enfermedad de newcastle), arn, metodo para generar copias de virus infeccioso de paramyxovirusaviar, copia de virus infeccioso, vacuna que comprende dicho virus, vacuna viva, metodo para distinguir animales no vacunados o animales vacunados, y - Google Patents
Adnc de paramyxovirus aviar (particularmente virus de la enfermedad de newcastle), arn, metodo para generar copias de virus infeccioso de paramyxovirusaviar, copia de virus infeccioso, vacuna que comprende dicho virus, vacuna viva, metodo para distinguir animales no vacunados o animales vacunados, yInfo
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- AR020091A1 AR020091A1 ARP990102948A ARP990102948A AR020091A1 AR 020091 A1 AR020091 A1 AR 020091A1 AR P990102948 A ARP990102948 A AR P990102948A AR P990102948 A ARP990102948 A AR P990102948A AR 020091 A1 AR020091 A1 AR 020091A1
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- vaccine
- ndv
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P33/00—Antiparasitic agents
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18111—Avulavirus, e.g. Newcastle disease virus
- C12N2760/18141—Use of virus, viral particle or viral elements as a vector
- C12N2760/18143—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Health & Medical Sciences (AREA)
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- Organic Chemistry (AREA)
- Genetics & Genomics (AREA)
- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
- Molecular Biology (AREA)
- Virology (AREA)
- Biomedical Technology (AREA)
- Medicinal Chemistry (AREA)
- Zoology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Wood Science & Technology (AREA)
- Biochemistry (AREA)
- Veterinary Medicine (AREA)
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- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
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- Animal Behavior & Ethology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Proteomics, Peptides & Aminoacids (AREA)
- Oncology (AREA)
- Gastroenterology & Hepatology (AREA)
- Communicable Diseases (AREA)
- Tropical Medicine & Parasitology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
- Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
ADNc de paramyxovirus aviar que contiene por lo menos una secuencia de ácido nucleico correspondiente al extremo terminal 5 del genoma del paramyxovirusaviar y que permite generar un minigenoma replicante de paramyxovirus aviar particularmente permite generar una copia infecciosa de paramyxovirus aviar,particularmente a partir de un ADNc de longitud total . Proceso para generar virus infeccioso de la Enfermedad de Newcastle (NDV) totalmente a partir de ADNcclonado de longitud total, y uso de vacunas y pruebas de diagnostico generadas con dicho proceso y derivadas del mismo. El proceso ofrece la posibilidad demodificar el genoma del NDV por medio de la modificacion genética y da lugar a la introduccion de mutaciones, delecciones y/o inserciones. Este proceso sepuede emplear para modificar la virulencia de NDV, generando así vacunas vivas atenuadas con propiedades mejoradas. Este proceso se puede usar para modificarla constitucion genética del NDV, permitiendo de esta manera la generacion de vacunas marcadoras vivas del NDV que se pueden distinguir serologicamente de lascepas de campo del NDV. Copia de virus infeccioso, vacuna que comprende dicho virus, vacuna viva, método para distinguir animales no vacunados o animalesvacunados ykit de diagnostico.
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP98202054A EP0974660A1 (en) | 1998-06-19 | 1998-06-19 | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| AR020091A1 true AR020091A1 (es) | 2002-04-10 |
Family
ID=8233832
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| ARP990102948A AR020091A1 (es) | 1998-06-19 | 1999-06-18 | Adnc de paramyxovirus aviar (particularmente virus de la enfermedad de newcastle), arn, metodo para generar copias de virus infeccioso de paramyxovirusaviar, copia de virus infeccioso, vacuna que comprende dicho virus, vacuna viva, metodo para distinguir animales no vacunados o animales vacunados, y |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US6719979B2 (es) |
| EP (2) | EP0974660A1 (es) |
| JP (3) | JP2002518012A (es) |
| KR (1) | KR20010053000A (es) |
| CN (2) | CN101275142A (es) |
| AR (1) | AR020091A1 (es) |
| AT (1) | ATE367442T1 (es) |
| AU (1) | AU754844B2 (es) |
| BR (1) | BR9911383A (es) |
| CA (1) | CA2334165A1 (es) |
| CZ (1) | CZ300760B6 (es) |
| DE (1) | DE69936585T2 (es) |
| DK (1) | DK1088077T3 (es) |
| EA (1) | EA004796B1 (es) |
| ES (1) | ES2291029T3 (es) |
| HR (1) | HRP20010042B1 (es) |
| HU (1) | HUP0102429A3 (es) |
| ID (1) | ID27343A (es) |
| IL (2) | IL140381A0 (es) |
| NO (1) | NO329193B1 (es) |
| NZ (1) | NZ508982A (es) |
| PL (1) | PL197722B1 (es) |
| PT (1) | PT1088077E (es) |
| SI (1) | SI1088077T1 (es) |
| TR (1) | TR200100350T2 (es) |
| UA (1) | UA77146C2 (es) |
| WO (1) | WO1999066045A1 (es) |
| ZA (1) | ZA200100241B (es) |
Families Citing this family (66)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
| US10383936B2 (en) * | 1999-05-05 | 2019-08-20 | University Of Maryland, College Park | Infectious laryngotracheitis virus (ILTV) vaccine using recombinant newcastle disease virus vector |
| AU4971500A (en) * | 1999-05-05 | 2000-11-21 | University Of Maryland | Production of novel newcastle disease virus strains from cdnas and improved liveattenuated newcastle disease vaccines |
| EP1074614B1 (en) * | 1999-07-27 | 2004-07-07 | Akzo Nobel N.V. | A recombinant Newcastle disease virus for in ovo vaccination |
| CA2312626A1 (en) | 1999-07-27 | 2001-01-27 | Akzo Nobel N.V. | A recombinant newcastle disease virus as an embryo vaccine |
| EP1297110B1 (en) * | 2000-06-23 | 2009-07-22 | Intervet International BV | Attenuated bovine respiratory syncytial virus |
| MXPA03003700A (es) * | 2000-11-02 | 2004-05-04 | Akzo Nobel Nv | Mutante de nucleoproteina recombinante de virus de enfermedad de newcastle en la forma de una vacuna marcadora. |
| KR100437888B1 (ko) * | 2001-07-30 | 2004-07-03 | 주식회사 인트론바이오테크놀로지 | 뉴캐슬병 바이러스 검출용 프라이머 및 상기 프라이머를이용한 뉴캐슬병 바이러스 검출, 병원성 및 유전형 조사방법 |
| IL145397A0 (en) * | 2001-09-12 | 2002-06-30 | Yissum Res Dev Co | Compositions and methods for treatment of cancer |
| US7615209B2 (en) | 2001-09-12 | 2009-11-10 | Yissum Research Development Company Of The Hebrew University Of Jerusalem | Compositions of NDV and methods of use thereof for treatment of cancer |
| EP1300157B1 (en) * | 2001-10-04 | 2005-10-26 | Centrum voor Onderzoek in Diergeneeskunde en Agrochemie | Attenuated mutant newcastle disease virus strains for in ovo vaccination and their use |
| JP2005518209A (ja) * | 2002-02-21 | 2005-06-23 | マウント シナイ スクール オブ メディシン | 組換えマイナス鎖ウイルスrna発現系およびワクチン |
| TW200502402A (en) * | 2002-12-06 | 2005-01-16 | Wyeth Corp | Escape mutants of newcastle disease virus as marker vaccines |
| NZ542933A (en) * | 2003-05-05 | 2009-08-28 | Dow Agrosciences Llc | Stable immunoprophylactic and therapeutic compositions derived from transgenic plant cells and methods for production |
| CN100393870C (zh) | 2003-05-05 | 2008-06-11 | 波依斯汤普森植物研究所 | 用于制备免疫保护性组合物的载体和来源于转基因植物的细胞 |
| CA2503774C (en) | 2003-06-20 | 2007-09-25 | Microbix Biosystems Inc. | Improvements in virus production |
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| MY146476A (en) | 2004-06-24 | 2012-08-15 | Boehringer Ingelheim Vetmed | Method of diagnosing lawsonia intracellularis |
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| CN101875919A (zh) | 2004-11-12 | 2010-11-03 | 拜耳先灵医药股份有限公司 | 重组新城疫病毒 |
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| US7951384B2 (en) * | 2005-08-05 | 2011-05-31 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| US9216212B2 (en) * | 2005-08-05 | 2015-12-22 | University Of Massachusetts | Virus-like particles as vaccines for paramyxovirus |
| EP2251034B1 (en) | 2005-12-02 | 2018-02-14 | Icahn School of Medicine at Mount Sinai | Chimeric newcastle disease viruses presenting non-native surface proteins and uses thereof |
| WO2007106882A2 (en) * | 2006-03-15 | 2007-09-20 | Intervet International B.V. | Recombinant mononegaviral virus vectors |
| EP1996610A1 (en) * | 2006-03-15 | 2008-12-03 | Intervet International BV | Recombinant newcastle disease virus expressing h5 hemagglutinin of avian influenza virus |
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| AU602875B2 (en) * | 1985-12-18 | 1990-11-01 | British Technology Group Limited | Newcastle disease virus gene clones |
| EP1394259A3 (en) | 1994-07-18 | 2004-04-14 | Karl-Klaus Prof. Dr. Conzelmann | Recombinant infectious non-segmented negative strand RNA virus |
| WO1996040880A1 (en) * | 1995-06-07 | 1996-12-19 | Syntro Corporation | Recombinant fowlpox viruses and uses thereof |
| ATE181112T1 (de) * | 1995-08-09 | 1999-06-15 | Schweiz Serum & Impfinst | Dem genom von minussträngigen rna-viren entsprechende cdna und verfahren zur herstellung von infektiösen minussträngigen rna-viren |
| EP0839912A1 (en) * | 1996-10-30 | 1998-05-06 | Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) | Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof |
| EP0974660A1 (en) | 1998-06-19 | 2000-01-26 | Stichting Instituut voor Dierhouderij en Diergezondheid (ID-DLO) | Newcastle disease virus infectious clones, vaccines and diagnostic assays |
| US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
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1998
- 1998-06-19 EP EP98202054A patent/EP0974660A1/en not_active Withdrawn
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1999
- 1999-06-17 IL IL14038199A patent/IL140381A0/xx active IP Right Grant
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- 1999-06-17 CN CNA2008100921449A patent/CN101275142A/zh active Pending
- 1999-06-17 PL PL348300A patent/PL197722B1/pl not_active IP Right Cessation
- 1999-06-17 CA CA002334165A patent/CA2334165A1/en not_active Abandoned
- 1999-06-17 HU HU0102429A patent/HUP0102429A3/hu unknown
- 1999-06-17 HR HR20010042A patent/HRP20010042B1/xx not_active IP Right Cessation
- 1999-06-17 ID IDW20010146A patent/ID27343A/id unknown
- 1999-06-17 DK DK99926984T patent/DK1088077T3/da active
- 1999-06-17 ES ES99926984T patent/ES2291029T3/es not_active Expired - Lifetime
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- 1999-06-17 CN CN99809714A patent/CN1314942A/zh active Pending
- 1999-06-17 PT PT99926984T patent/PT1088077E/pt unknown
- 1999-06-17 KR KR1020007014397A patent/KR20010053000A/ko not_active Ceased
- 1999-06-17 JP JP2000554854A patent/JP2002518012A/ja not_active Withdrawn
- 1999-06-17 NZ NZ508982A patent/NZ508982A/en unknown
- 1999-06-17 CZ CZ20004707A patent/CZ300760B6/cs not_active IP Right Cessation
- 1999-06-17 WO PCT/NL1999/000377 patent/WO1999066045A1/en not_active Ceased
- 1999-06-17 AT AT99926984T patent/ATE367442T1/de active
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- 1999-06-17 EA EA200100057A patent/EA004796B1/ru not_active IP Right Cessation
- 1999-06-17 AU AU43991/99A patent/AU754844B2/en not_active Ceased
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- 1999-06-17 BR BR9911383-0A patent/BR9911383A/pt not_active IP Right Cessation
- 1999-06-18 AR ARP990102948A patent/AR020091A1/es not_active Application Discontinuation
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2000
- 2000-12-15 NO NO20006406A patent/NO329193B1/no not_active IP Right Cessation
- 2000-12-18 IL IL140381A patent/IL140381A/en not_active IP Right Cessation
- 2000-12-19 US US09/741,744 patent/US6719979B2/en not_active Expired - Fee Related
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2001
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2004
- 2004-02-26 US US10/788,232 patent/US7332169B2/en not_active Expired - Fee Related
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2005
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2009
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