BR0207988A - Cepas atenuadas vivas de vìrus de prrs - Google Patents
Cepas atenuadas vivas de vìrus de prrsInfo
- Publication number
- BR0207988A BR0207988A BR0207988-7A BR0207988A BR0207988A BR 0207988 A BR0207988 A BR 0207988A BR 0207988 A BR0207988 A BR 0207988A BR 0207988 A BR0207988 A BR 0207988A
- Authority
- BR
- Brazil
- Prior art keywords
- prrs virus
- virus
- live attenuated
- attenuated strains
- attenuated
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 241000700605 Viruses Species 0.000 title abstract 7
- 230000002238 attenuated effect Effects 0.000 title abstract 3
- 208000005342 Porcine Reproductive and Respiratory Syndrome Diseases 0.000 abstract 4
- 101000977023 Azospirillum brasilense Uncharacterized 17.8 kDa protein in nodG 5'region Proteins 0.000 abstract 1
- 101000961984 Bacillus thuringiensis Uncharacterized 30.3 kDa protein Proteins 0.000 abstract 1
- 101000644901 Drosophila melanogaster Putative 115 kDa protein in type-1 retrotransposable element R1DM Proteins 0.000 abstract 1
- 101000747702 Enterobacteria phage N4 Uncharacterized protein Gp2 Proteins 0.000 abstract 1
- 101000758599 Escherichia coli Uncharacterized 14.7 kDa protein Proteins 0.000 abstract 1
- 101000768930 Lactococcus lactis subsp. cremoris Uncharacterized protein in pepC 5'region Proteins 0.000 abstract 1
- 101000976302 Leptospira interrogans Uncharacterized protein in sph 3'region Proteins 0.000 abstract 1
- 101000778886 Leptospira interrogans serogroup Icterohaemorrhagiae serovar Lai (strain 56601) Uncharacterized protein LA_2151 Proteins 0.000 abstract 1
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 abstract 1
- 101001121571 Rice tungro bacilliform virus (isolate Philippines) Protein P2 Proteins 0.000 abstract 1
- 101000818098 Spirochaeta aurantia Uncharacterized protein in trpE 3'region Proteins 0.000 abstract 1
- 101001026590 Streptomyces cinnamonensis Putative polyketide beta-ketoacyl synthase 2 Proteins 0.000 abstract 1
- 101000750896 Synechococcus elongatus (strain PCC 7942 / FACHB-805) Uncharacterized protein Synpcc7942_2318 Proteins 0.000 abstract 1
- 108010067390 Viral Proteins Proteins 0.000 abstract 1
- 101000916321 Xenopus laevis Transposon TX1 uncharacterized 149 kDa protein Proteins 0.000 abstract 1
- 101000760088 Zymomonas mobilis subsp. mobilis (strain ATCC 10988 / DSM 424 / LMG 404 / NCIMB 8938 / NRRL B-806 / ZM1) 20.9 kDa protein Proteins 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 238000011321 prophylaxis Methods 0.000 abstract 1
- 238000011282 treatment Methods 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
- C12N2770/00011—Details
- C12N2770/10011—Arteriviridae
- C12N2770/10061—Methods of inactivation or attenuation
- C12N2770/10062—Methods of inactivation or attenuation by genetic engineering
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Genetics & Genomics (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Virology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Microbiology (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Public Health (AREA)
- Immunology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Endocrinology (AREA)
- Reproductive Health (AREA)
- Pulmonology (AREA)
- Gastroenterology & Hepatology (AREA)
- Biophysics (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Peptides Or Proteins (AREA)
Abstract
"CEPAS ATENUADAS VIVAS DE VìRUS DE PRRS". A presente invenção refere-se ao vírus PRRS Europeu atenuado que são atenuados por mutações de ácido nucléico em sítios específicos da proteína viral codificada por ORF 2, 3 e 5. A invenção também pertence à seq³ência de nucleotídeo codificando referido vírus, método de gerar tal vírus e uma composição farmacêutica compreendendo referido vírus PRRS e então o uso de referido vírus PRRS na preparação de uma vacina para a profilaxia e tratamento de infecções PRRSV.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US27460301P | 2001-03-09 | 2001-03-09 | |
PCT/EP2002/002486 WO2002072802A2 (en) | 2001-03-09 | 2002-03-07 | Live attenuated strains of prrs virus |
Publications (1)
Publication Number | Publication Date |
---|---|
BR0207988A true BR0207988A (pt) | 2004-10-26 |
Family
ID=23048885
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR0207988-7A Pending BR0207988A (pt) | 2001-03-09 | 2002-03-07 | Cepas atenuadas vivas de vìrus de prrs |
Country Status (12)
Country | Link |
---|---|
EP (1) | EP1421184A2 (pt) |
JP (1) | JP2004534522A (pt) |
KR (1) | KR20030082960A (pt) |
BR (1) | BR0207988A (pt) |
CA (1) | CA2439254A1 (pt) |
CZ (1) | CZ20032743A3 (pt) |
HU (1) | HUP0303431A2 (pt) |
MX (1) | MXPA03007751A (pt) |
PL (1) | PL370541A1 (pt) |
RU (1) | RU2003129068A (pt) |
SK (1) | SK11282003A3 (pt) |
WO (1) | WO2002072802A2 (pt) |
Families Citing this family (18)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1438969A1 (en) * | 2003-01-14 | 2004-07-21 | Universiteit Utrecht | Arterivirus marker vaccine |
KR20050040172A (ko) * | 2003-10-27 | 2005-05-03 | 주식회사 중앙백신연구소 | 돼지 생식기호흡기 증후군 바이러스 불활화 백신의 제조방법 |
WO2006055331A2 (en) * | 2004-11-19 | 2006-05-26 | Intervet International B.V. | Porcine reproductive and respiratory syndrome virus strains and compositions |
KR20100090311A (ko) * | 2005-02-25 | 2010-08-13 | 화이자 프로덕츠 인크. | 돼지 생식기 호흡기 증후군 바이러스의 n 단백질 돌연변이체 |
US8709730B2 (en) | 2007-04-05 | 2014-04-29 | Icahn School Of Medicine At Mount Sinai | Methods of preventing and treating viral infections by inhibiting the deISGylation activity of OTU domain-containing viral proteins |
CN101454442A (zh) * | 2007-06-15 | 2009-06-10 | 普泰克国际有限公司 | 嵌合体prrsv的构建,组合物及疫苗的制备 |
US7666585B2 (en) | 2007-06-15 | 2010-02-23 | Protatek International, Inc. | Construction of chimera PRRSV, compositions and vaccine preparations |
WO2012110489A2 (en) * | 2011-02-17 | 2012-08-23 | Boehringer Ingelheim Vetmedica Gmbh | Novel european prrsv strain |
KR101420850B1 (ko) * | 2011-05-30 | 2014-08-13 | 건국대학교 산학협력단 | 돼지 생식기 호흡기 증후군 바이러스 유사입자 및 이를 이용한 백신 |
KR101281361B1 (ko) * | 2011-07-18 | 2013-07-02 | 서울대학교산학협력단 | 북미형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 및 이를 포함하는 혼합백신 조성물 |
KR101245029B1 (ko) * | 2012-01-18 | 2013-03-18 | 서울대학교산학협력단 | 한국형 돼지 생식기 호흡기 증후군 바이러스 예방 백신 조성물 |
MX2014013964A (es) * | 2012-05-17 | 2015-03-04 | Zoetis Llc | Vacunacion eficaz contral el virus del sindrome reproductivo y respiratorio porcino (prrs) antes del destete. |
CN103290142B (zh) * | 2013-03-29 | 2015-03-11 | 云南农业大学 | 荧光定量rt-pcr检测猪蓝耳病弱毒疫苗病毒含量的方法 |
KR101624485B1 (ko) | 2014-08-13 | 2016-05-26 | 전북대학교산학협력단 | 돼지생식기호흡기증후군 바이러스(prrsv) 변이주 및 이를 포함하는 돼지 생식기 호흡기 증후군 예방 또는 치료용 백신 조성물 |
CN104694561B (zh) * | 2015-02-10 | 2018-02-23 | 中国农业科学院上海兽医研究所 | 表达海肾或萤火虫荧光素酶基因的prrsv重组质粒的构建方法以及应用 |
MX2021015938A (es) * | 2019-08-29 | 2022-04-26 | Elanco Us Inc | Virus para vacuna contra el síndrome respiratorio y reproductivo porcino. |
WO2021154055A1 (ko) * | 2020-01-29 | 2021-08-05 | 주식회사 바이오포아 | 유럽형 돼지 생식기 호흡기 증후군 바이러스의 변이주 및 이를 포함하는 백신 조성물 |
KR102276341B1 (ko) * | 2020-01-29 | 2021-07-12 | 주식회사 바이오포아 | 유럽형 돼지 생식기 호흡기 증후군 바이러스의 제조 방법 및 이의 용도 |
Family Cites Families (9)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
ATE118352T1 (de) * | 1991-06-06 | 1995-03-15 | Stichting Centr Diergeneeskund | Erreger der mysteriösen schweinekrankheit,impfstoff-zusammensetzungen und diagnose kits. |
US6592873B1 (en) * | 1992-10-30 | 2003-07-15 | Iowa State University Research Foundation, Inc. | Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids |
CN1259141B (zh) * | 1997-05-06 | 2013-03-27 | 勃林格殷格汉动物保健有限公司 | 用于疫苗或诊断测试中的鉴定prrs病毒的肽序列的prrsv抗原位点 |
AU7960598A (en) * | 1997-06-05 | 1998-12-21 | Origen, Inc. | Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine |
JP3961222B2 (ja) * | 1999-03-08 | 2007-08-22 | ベーリンガー インゲルハイム フェトメディカ ゲーエムベーハー | Prrsvワクチン |
WO2001055353A2 (en) * | 2000-01-26 | 2001-08-02 | Boehringer Ingelheim Vetmedica Gmbh | Recombinant attenuation of prrsv |
EP1156111A1 (en) * | 2000-05-19 | 2001-11-21 | Stichting Dienst Landbouwkundig Onderzoek | Chimeric arterivirus-like particles |
EP1283718A2 (en) * | 2000-05-24 | 2003-02-19 | Merial | Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine |
EP1397498A1 (en) * | 2001-05-21 | 2004-03-17 | ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. | Delections in arterivirus replicons |
-
2002
- 2002-03-07 MX MXPA03007751A patent/MXPA03007751A/es unknown
- 2002-03-07 JP JP2002571858A patent/JP2004534522A/ja active Pending
- 2002-03-07 BR BR0207988-7A patent/BR0207988A/pt active Pending
- 2002-03-07 EP EP02726146A patent/EP1421184A2/en not_active Withdrawn
- 2002-03-07 CA CA002439254A patent/CA2439254A1/en not_active Abandoned
- 2002-03-07 SK SK1128-2003A patent/SK11282003A3/sk unknown
- 2002-03-07 RU RU2003129068/13A patent/RU2003129068A/ru not_active Application Discontinuation
- 2002-03-07 WO PCT/EP2002/002486 patent/WO2002072802A2/en not_active Application Discontinuation
- 2002-03-07 PL PL02370541A patent/PL370541A1/xx not_active Application Discontinuation
- 2002-03-07 HU HU0303431A patent/HUP0303431A2/hu unknown
- 2002-03-07 CZ CZ20032743A patent/CZ20032743A3/cs unknown
- 2002-03-07 KR KR10-2003-7011656A patent/KR20030082960A/ko not_active Application Discontinuation
Also Published As
Publication number | Publication date |
---|---|
JP2004534522A (ja) | 2004-11-18 |
EP1421184A2 (en) | 2004-05-26 |
SK11282003A3 (sk) | 2004-02-03 |
KR20030082960A (ko) | 2003-10-23 |
WO2002072802A3 (en) | 2004-03-11 |
MXPA03007751A (es) | 2004-11-12 |
RU2003129068A (ru) | 2005-04-10 |
CA2439254A1 (en) | 2002-09-19 |
WO2002072802A2 (en) | 2002-09-19 |
CZ20032743A3 (cs) | 2004-02-18 |
PL370541A1 (en) | 2005-05-30 |
HUP0303431A2 (hu) | 2004-01-28 |
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Legal Events
Date | Code | Title | Description |
---|---|---|---|
B11A | Dismissal acc. art.33 of ipl - examination not requested within 36 months of filing | ||
B11Y | Definitive dismissal - extension of time limit for request of examination expired [chapter 11.1.1 patent gazette] |