WO2002072802A3 - Live attenuated strains of prrs virus - Google Patents

Live attenuated strains of prrs virus Download PDF

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Publication number
WO2002072802A3
WO2002072802A3 PCT/EP2002/002486 EP0202486W WO02072802A3 WO 2002072802 A3 WO2002072802 A3 WO 2002072802A3 EP 0202486 W EP0202486 W EP 0202486W WO 02072802 A3 WO02072802 A3 WO 02072802A3
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WO
WIPO (PCT)
Prior art keywords
viruses
live attenuated
prrs virus
prrs
attenuated strains
Prior art date
Application number
PCT/EP2002/002486
Other languages
French (fr)
Other versions
WO2002072802A2 (en
Inventor
Knut Elbers
Stefan Peschke
Bettina Schuetz
Original Assignee
Boehringer Ingelheim Vetmed
Knut Elbers
Stefan Peschke
Bettina Schuetz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmed, Knut Elbers, Stefan Peschke, Bettina Schuetz filed Critical Boehringer Ingelheim Vetmed
Priority to MXPA03007751A priority Critical patent/MXPA03007751A/en
Priority to CA002439254A priority patent/CA2439254A1/en
Priority to JP2002571858A priority patent/JP2004534522A/en
Priority to EP02726146A priority patent/EP1421184A2/en
Priority to BR0207988-7A priority patent/BR0207988A/en
Priority to HU0303431A priority patent/HUP0303431A2/en
Priority to SK1128-2003A priority patent/SK11282003A3/en
Priority to KR10-2003-7011656A priority patent/KR20030082960A/en
Publication of WO2002072802A2 publication Critical patent/WO2002072802A2/en
Publication of WO2002072802A3 publication Critical patent/WO2002072802A3/en

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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10062—Methods of inactivation or attenuation by genetic engineering

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Reproductive Health (AREA)
  • Endocrinology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

The present invention realtes to live attenuated European PRRS viruses which are attenuated by nucleic acid mutations on specific sties of the viral protein coded by ORF 2, 3 and 5. The invention also pertains to nucleotide sequences coding said viruses, methods of generating such viruses and a pharmaceutical composition comprising said PRRS viruses and teh use of said PRRS virus in the manufacture of a vaccine for the prophylaxis and treatment of PRRSV infections.
PCT/EP2002/002486 2001-03-09 2002-03-07 Live attenuated strains of prrs virus WO2002072802A2 (en)

Priority Applications (8)

Application Number Priority Date Filing Date Title
MXPA03007751A MXPA03007751A (en) 2001-03-09 2002-03-07 Life attenuated strains of prrs virus.
CA002439254A CA2439254A1 (en) 2001-03-09 2002-03-07 Life attenuated strains of prrs virus
JP2002571858A JP2004534522A (en) 2001-03-09 2002-03-07 A live attenuated PRRS virus strain
EP02726146A EP1421184A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus
BR0207988-7A BR0207988A (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus
HU0303431A HUP0303431A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus
SK1128-2003A SK11282003A3 (en) 2001-03-09 2002-03-07 Life attenuated European PRRS virus, nucleotide sequence coding said virus, method of generating such virus, cell line, and a pharmaceutical composition comprising said PRRS viruses and the use thereof
KR10-2003-7011656A KR20030082960A (en) 2001-03-09 2002-03-07 Life attenuated strains of PRRS virus

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27460301P 2001-03-09 2001-03-09
US60/274,603 2001-03-09

Publications (2)

Publication Number Publication Date
WO2002072802A2 WO2002072802A2 (en) 2002-09-19
WO2002072802A3 true WO2002072802A3 (en) 2004-03-11

Family

ID=23048885

Family Applications (1)

Application Number Title Priority Date Filing Date
PCT/EP2002/002486 WO2002072802A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus

Country Status (12)

Country Link
EP (1) EP1421184A2 (en)
JP (1) JP2004534522A (en)
KR (1) KR20030082960A (en)
BR (1) BR0207988A (en)
CA (1) CA2439254A1 (en)
CZ (1) CZ20032743A3 (en)
HU (1) HUP0303431A2 (en)
MX (1) MXPA03007751A (en)
PL (1) PL370541A1 (en)
RU (1) RU2003129068A (en)
SK (1) SK11282003A3 (en)
WO (1) WO2002072802A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1438969A1 (en) * 2003-01-14 2004-07-21 Universiteit Utrecht Arterivirus marker vaccine
KR20050040172A (en) * 2003-10-27 2005-05-03 주식회사 중앙백신연구소 Method of porcine reproductive and respiratory syndrome inactivated oil vaccine
BRPI0518353A2 (en) * 2004-11-19 2008-11-18 Intervet Int Bv immunogenic composition, attenuated porcine respiratory and reproductive syndrome virus, and method for protecting a pig against porcine respiratory and reproductive syndrome
WO2006129139A1 (en) * 2005-02-25 2006-12-07 Pfizer Products Inc. N protein mutants of porcine reproductive and respiratory syndrome virus
US8709730B2 (en) 2007-04-05 2014-04-29 Icahn School Of Medicine At Mount Sinai Methods of preventing and treating viral infections by inhibiting the deISGylation activity of OTU domain-containing viral proteins
CN101454442A (en) * 2007-06-15 2009-06-10 普泰克国际有限公司 Construction of chimera PRRSV, compositions and vaccine preparations
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
ME02271B (en) * 2011-02-17 2016-02-20 Boehringer Ingelheim Vetmedica Gmbh Novel european prrsv strain
KR101420850B1 (en) * 2011-05-30 2014-08-13 건국대학교 산학협력단 A novel virus like particle of Porcine reproductive and respiratory syndrome virus and vaccine thereof
KR101281361B1 (en) * 2011-07-18 2013-07-02 서울대학교산학협력단 Vaccine composition for North American Porcine reproductive and respiratory syndrome virus and mixed vaccine comprising thereof
KR101245029B1 (en) * 2012-01-18 2013-03-18 서울대학교산학협력단 Vaccine composition for Korean Porcine reproductive and respiratory syndrome virus
KR102012109B1 (en) * 2012-05-17 2019-08-19 조에티스 엘엘씨 Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning
CN103290142B (en) * 2013-03-29 2015-03-11 云南农业大学 A fluorescent quantitative RT-PCR method for detection of a porcine reproductive and respiratory syndrome (PRRS) attenuated vaccine virus content
KR101624485B1 (en) 2014-08-13 2016-05-26 전북대학교산학협력단 Porcine reproductive and respiratory syndrome virus mutant strain and vaccine composition for preventing or treating porcine reproductive and respiratory syndrome comprising the same
CN104694561B (en) * 2015-02-10 2018-02-23 中国农业科学院上海兽医研究所 Express construction method and the application of the PRRSV recombinant plasmids of sea pansy or firefly luciferase gene
AU2019463018A1 (en) * 2019-08-29 2022-02-03 Elanco Uk Ah Limited Porcine reproductive and respiratory syndrome vaccine virus
KR102276341B1 (en) * 2020-01-29 2021-07-12 주식회사 바이오포아 Method for producing European porcine reproductive and respiratory syndrome virus and use thereof
WO2021154055A1 (en) * 2020-01-29 2021-08-05 주식회사 바이오포아 Mutant strain of european porcine reproductive and respiratory syndrome virus and vaccine composition comprising same

Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
WO1996006619A1 (en) * 1994-09-01 1996-03-07 Paul Prem S Polynucleic acids and proteins from a porcine reproductive and respiratory syndrome virus and uses thereof
WO1998050426A1 (en) * 1997-05-06 1998-11-12 Stichting Dienst Landbouwkundig Onderzoek Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
WO1998055626A2 (en) * 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
WO2001055353A2 (en) * 2000-01-26 2001-08-02 Boehringer Ingelheim Vetmedica Gmbh Recombinant attenuation of prrsv
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
WO2001089559A2 (en) * 2000-05-24 2001-11-29 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
WO2002095040A1 (en) * 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons

Patent Citations (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1992021375A1 (en) * 1991-06-06 1992-12-10 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
WO1996006619A1 (en) * 1994-09-01 1996-03-07 Paul Prem S Polynucleic acids and proteins from a porcine reproductive and respiratory syndrome virus and uses thereof
WO1998050426A1 (en) * 1997-05-06 1998-11-12 Stichting Dienst Landbouwkundig Onderzoek Prrsv antigenic sites identifying peptide sequences of prrs virus for use in vaccines or diagnostic assays
WO1998055626A2 (en) * 1997-06-05 1998-12-10 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
WO2001055353A2 (en) * 2000-01-26 2001-08-02 Boehringer Ingelheim Vetmedica Gmbh Recombinant attenuation of prrsv
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
WO2001089559A2 (en) * 2000-05-24 2001-11-29 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
WO2002095040A1 (en) * 2001-05-21 2002-11-28 Id-Lelystad, Instituut Voor Dierhouderij En Diergezondheid B.V. Delections in arterivirus replicons

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
ALLENDE R ET AL: "Mutations in the genome of porcine reproductive and respiratory syndrome virus responsible for the attenuation phenotype", ARCHIVES OF VIROLOGY, NEW YORK, NY, US, vol. 145, no. 6, June 2000 (2000-06-01), pages 1149 - 1161, XP000926571, ISSN: 0304-8608 *
YANG S X ET AL: "Comparative sequence analysis of open reading frames 2 to 7 of the modified live vaccine virus and other North American isolates of the porcine reproductive and respiratory syndrome virus", ARCHIVES OF VIROLOGY, NEW YORK, NY, US, vol. 143, no. 3, 1998, pages 601 - 612, XP000926565, ISSN: 0304-8608 *

Also Published As

Publication number Publication date
RU2003129068A (en) 2005-04-10
CA2439254A1 (en) 2002-09-19
WO2002072802A2 (en) 2002-09-19
KR20030082960A (en) 2003-10-23
BR0207988A (en) 2004-10-26
PL370541A1 (en) 2005-05-30
HUP0303431A2 (en) 2004-01-28
SK11282003A3 (en) 2004-02-03
JP2004534522A (en) 2004-11-18
MXPA03007751A (en) 2004-11-12
EP1421184A2 (en) 2004-05-26
CZ20032743A3 (en) 2004-02-18

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