HUP0303431A2 - Live attenuated strains of prrs virus - Google Patents

Live attenuated strains of prrs virus

Info

Publication number
HUP0303431A2
HUP0303431A2 HU0303431A HUP0303431A HUP0303431A2 HU P0303431 A2 HUP0303431 A2 HU P0303431A2 HU 0303431 A HU0303431 A HU 0303431A HU P0303431 A HUP0303431 A HU P0303431A HU P0303431 A2 HUP0303431 A2 HU P0303431A2
Authority
HU
Hungary
Prior art keywords
viruses
prrs
live attenuated
prrs virus
attenuated strains
Prior art date
Application number
HU0303431A
Other languages
Hungarian (hu)
Inventor
Knut Elbers
Stefan Peschke
Bettina Schuetz
Original Assignee
Boehringer Ingelheim Vetmedica Gmbh
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Boehringer Ingelheim Vetmedica Gmbh filed Critical Boehringer Ingelheim Vetmedica Gmbh
Publication of HUP0303431A2 publication Critical patent/HUP0303431A2/en

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P11/00—Drugs for disorders of the respiratory system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10021—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation
    • C12N2770/10062—Methods of inactivation or attenuation by genetic engineering

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Virology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biomedical Technology (AREA)
  • Veterinary Medicine (AREA)
  • Immunology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Public Health (AREA)
  • Pulmonology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biophysics (AREA)
  • Molecular Biology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Endocrinology (AREA)
  • Reproductive Health (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)

Abstract

A találmány tárgyát olyan élő, legyengített, európai PRRS vírusokképezik, amelyek speciális helyekre bevitt nukleinsav-mutációkkalvannak legyengítve. A találmány tárgyát képezik az említett vírusokatkódoló nukleotidszekvenciák is, eljárások ilyen vírusok és az említettPRRS vírusokat tartalmazó gyógyszerkészítmény előállítására, valamintaz említett PRRS vírus alkalmazása PRRS-fertőzések profilaxisára éskezelésére alkalmas vakcina gyártásában. ÓThe subject of the invention is live attenuated European PRRS viruses that are attenuated by nucleic acid mutations introduced at specific sites. The subject of the invention are also the nucleotide sequences encoding said viruses, methods for producing such viruses and pharmaceutical preparations containing said PRRS viruses, as well as the use of said PRRS virus in the production of a vaccine suitable for the prophylaxis and treatment of PRRS infections. HE

HU0303431A 2001-03-09 2002-03-07 Live attenuated strains of prrs virus HUP0303431A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US27460301P 2001-03-09 2001-03-09
PCT/EP2002/002486 WO2002072802A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus

Publications (1)

Publication Number Publication Date
HUP0303431A2 true HUP0303431A2 (en) 2004-01-28

Family

ID=23048885

Family Applications (1)

Application Number Title Priority Date Filing Date
HU0303431A HUP0303431A2 (en) 2001-03-09 2002-03-07 Live attenuated strains of prrs virus

Country Status (12)

Country Link
EP (1) EP1421184A2 (en)
JP (1) JP2004534522A (en)
KR (1) KR20030082960A (en)
BR (1) BR0207988A (en)
CA (1) CA2439254A1 (en)
CZ (1) CZ20032743A3 (en)
HU (1) HUP0303431A2 (en)
MX (1) MXPA03007751A (en)
PL (1) PL370541A1 (en)
RU (1) RU2003129068A (en)
SK (1) SK11282003A3 (en)
WO (1) WO2002072802A2 (en)

Families Citing this family (18)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1438969A1 (en) * 2003-01-14 2004-07-21 Universiteit Utrecht Arterivirus marker vaccine
KR20050040172A (en) * 2003-10-27 2005-05-03 주식회사 중앙백신연구소 Method of porcine reproductive and respiratory syndrome inactivated oil vaccine
KR101152012B1 (en) * 2004-11-19 2012-07-04 인터벳 인터내셔널 비.브이. Porcine reproductive and respiratory syndrome virus strains and compositions
KR100996105B1 (en) * 2005-02-25 2010-11-22 화이자 프로덕츠 인크. N Protein Mutants of Porcine Reproductive and Respiratory Syndrome Virus
US8709730B2 (en) 2007-04-05 2014-04-29 Icahn School Of Medicine At Mount Sinai Methods of preventing and treating viral infections by inhibiting the deISGylation activity of OTU domain-containing viral proteins
WO2008153572A1 (en) * 2007-06-15 2008-12-18 Protatek International, Inc. Construction of chimera prrsv, compositions and vaccine preparations
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
KR102183276B1 (en) * 2011-02-17 2020-11-26 베링거잉겔하임베트메디카게엠베하 Novel european prrsv strain
KR101420850B1 (en) * 2011-05-30 2014-08-13 건국대학교 산학협력단 A novel virus like particle of Porcine reproductive and respiratory syndrome virus and vaccine thereof
KR101281361B1 (en) * 2011-07-18 2013-07-02 서울대학교산학협력단 Vaccine composition for North American Porcine reproductive and respiratory syndrome virus and mixed vaccine comprising thereof
KR101245029B1 (en) * 2012-01-18 2013-03-18 서울대학교산학협력단 Vaccine composition for Korean Porcine reproductive and respiratory syndrome virus
MX2014013964A (en) * 2012-05-17 2015-03-04 Zoetis Llc Effective vaccination against porcine reproductive and respiratory syndrome (prrs) virus prior to weaning.
CN103290142B (en) * 2013-03-29 2015-03-11 云南农业大学 A fluorescent quantitative RT-PCR method for detection of a porcine reproductive and respiratory syndrome (PRRS) attenuated vaccine virus content
KR101624485B1 (en) 2014-08-13 2016-05-26 전북대학교산학협력단 Porcine reproductive and respiratory syndrome virus mutant strain and vaccine composition for preventing or treating porcine reproductive and respiratory syndrome comprising the same
CN104694561B (en) * 2015-02-10 2018-02-23 中国农业科学院上海兽医研究所 Express construction method and the application of the PRRSV recombinant plasmids of sea pansy or firefly luciferase gene
CA3144160A1 (en) * 2019-08-29 2021-03-04 Elanco Us Inc. Porcine reproductive and respiratory syndrome vaccine virus
KR102276341B1 (en) * 2020-01-29 2021-07-12 주식회사 바이오포아 Method for producing European porcine reproductive and respiratory syndrome virus and use thereof
WO2021154055A1 (en) * 2020-01-29 2021-08-05 주식회사 바이오포아 Mutant strain of european porcine reproductive and respiratory syndrome virus and vaccine composition comprising same

Family Cites Families (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CA2290906C (en) * 1991-06-06 2003-04-01 Stichting Centraal Diergeneeskundig Instituut Causative agent of the mystery swine disease, vaccine compositions and diagnostic kits
US6592873B1 (en) * 1992-10-30 2003-07-15 Iowa State University Research Foundation, Inc. Polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus (PRRSV) and proteins encoded by the polynucleic acids
WO2000053787A1 (en) * 1999-03-08 2000-09-14 Id-Lelystad, Instituut Voor Dierhouderij En Dierg Ezondheid B.V. Prrsv vaccines
DK0980387T3 (en) * 1997-05-06 2007-10-22 Boehringer Ingelheim Vetmed PRRSV antigenic sites that identify peptide sequences of PRRS virus for use in vaccines or diagnostic assays
AU7960598A (en) * 1997-06-05 1998-12-21 Origen, Inc. Recombinant porcine reproductive and respiratory syndrome virus (prrsv) for use as a vaccine
EA200200743A1 (en) * 2000-01-26 2002-12-26 Бёрингер Ингельхайм Ветмедика Кг RECOMBINANT REDUCTION OF THE VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME OF PIGS (PRRSV)
EP1156111A1 (en) * 2000-05-19 2001-11-21 Stichting Dienst Landbouwkundig Onderzoek Chimeric arterivirus-like particles
AU2001256582A1 (en) * 2000-05-24 2001-12-03 Merial Porcine reproductive and respiratory syndrome virus (prrsv) recombinant avipoxvirus vaccine
EP1397498A1 (en) * 2001-05-21 2004-03-17 ID-Lelystad, Instituut voor Dierhouderij en Diergezondheid B.V. Delections in arterivirus replicons

Also Published As

Publication number Publication date
SK11282003A3 (en) 2004-02-03
JP2004534522A (en) 2004-11-18
RU2003129068A (en) 2005-04-10
EP1421184A2 (en) 2004-05-26
CA2439254A1 (en) 2002-09-19
WO2002072802A3 (en) 2004-03-11
WO2002072802A2 (en) 2002-09-19
PL370541A1 (en) 2005-05-30
KR20030082960A (en) 2003-10-23
CZ20032743A3 (en) 2004-02-18
MXPA03007751A (en) 2004-11-12
BR0207988A (en) 2004-10-26

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