EA200200743A1 - RECOMBINANT REDUCTION OF THE VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME OF PIGS (PRRSV) - Google Patents

RECOMBINANT REDUCTION OF THE VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME OF PIGS (PRRSV)

Info

Publication number
EA200200743A1
EA200200743A1 EA200200743A EA200200743A EA200200743A1 EA 200200743 A1 EA200200743 A1 EA 200200743A1 EA 200200743 A EA200200743 A EA 200200743A EA 200200743 A EA200200743 A EA 200200743A EA 200200743 A1 EA200200743 A1 EA 200200743A1
Authority
EA
Eurasian Patent Office
Prior art keywords
orf
viruses
prrsv
pigs
recombinant
Prior art date
Application number
EA200200743A
Other languages
Russian (ru)
Inventor
Кнут Эльберс
Штефан Пеш
Хайке Драйер
Original Assignee
Бёрингер Ингельхайм Ветмедика Кг
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from DE2000103372 external-priority patent/DE10003372A1/en
Priority claimed from DE2000103371 external-priority patent/DE10003371A1/en
Priority claimed from DE2000103373 external-priority patent/DE10003373A1/en
Application filed by Бёрингер Ингельхайм Ветмедика Кг filed Critical Бёрингер Ингельхайм Ветмедика Кг
Publication of EA200200743A1 publication Critical patent/EA200200743A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • C12N7/04—Inactivation or attenuation; Producing viral sub-units
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/52—Bacterial cells; Fungal cells; Protozoal cells
    • A61K2039/522—Bacterial cells; Fungal cells; Protozoal cells avirulent or attenuated
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
    • A61K2039/525—Virus
    • A61K2039/5254—Virus avirulent or attenuated
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10022—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/10011—Arteriviridae
    • C12N2770/10061—Methods of inactivation or attenuation

Abstract

В заявке описаны живые вирусы PRRS, ослабленные в результате аминокислотных мутаций в специфическом сайте вирусного протеина, кодируемого открытой рамкой считывания (ОРС), выбранной из группы, включающей ОРС 1а, ОРС 1b и/или ОРС 2. Изобретение относится также к нуклеотидным последовательностям вирусов, способам получения таких вирусов и их применению для приготовления фармацевтической композиции, предназначенной для профилактики и лечения PRRS-инфекций.Отчет о международном поиске был опубликован 2001.12.27.The application describes live PRRS viruses weakened by amino acid mutations in the specific site of the viral protein encoded by the open reading frame (ORF) selected from the group including ORF 1a, ORF 1b and / or ORF 2. The invention also relates to nucleotide sequences of viruses, methods for producing such viruses and their use for the preparation of a pharmaceutical composition intended for the prevention and treatment of PRRS infections. The international search report was published 2001.12.27.

EA200200743A 2000-01-26 2001-01-26 RECOMBINANT REDUCTION OF THE VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME OF PIGS (PRRSV) EA200200743A1 (en)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
DE2000103372 DE10003372A1 (en) 2000-01-26 2000-01-26 Novel live porcine reproductive and respiratory syndrome virus attenuated by mutations in specific site of viral protein coded by specified open reading frames, useful for prophylaxis/treatment of viral infections
DE2000103371 DE10003371A1 (en) 2000-01-26 2000-01-26 Novel live porcine reproductive and respiratory syndrome virus attenuated by mutations in specific site of viral protein coded by specified open reading frames, useful for prophylaxis/treatment of viral infections
DE2000103373 DE10003373A1 (en) 2000-01-26 2000-01-26 Novel live porcine reproductive and respiratory syndrome virus attenuated by mutations in specific site of viral protein coded by specified open reading frames, useful for prophylaxis/treatment of viral infections
PCT/EP2001/000865 WO2001055353A2 (en) 2000-01-26 2001-01-26 Recombinant attenuation of prrsv

Publications (1)

Publication Number Publication Date
EA200200743A1 true EA200200743A1 (en) 2002-12-26

Family

ID=27213605

Family Applications (1)

Application Number Title Priority Date Filing Date
EA200200743A EA200200743A1 (en) 2000-01-26 2001-01-26 RECOMBINANT REDUCTION OF THE VIRUS REPRODUCTIVE AND RESPIRATORY SYNDROME OF PIGS (PRRSV)

Country Status (15)

Country Link
EP (1) EP1254213A2 (en)
JP (1) JP2003520601A (en)
KR (1) KR20030032910A (en)
CN (1) CN1406277A (en)
AR (1) AR027291A1 (en)
AU (1) AU2001228502A1 (en)
BR (1) BR0107827A (en)
CA (1) CA2396454A1 (en)
CZ (1) CZ20022554A3 (en)
EA (1) EA200200743A1 (en)
HU (1) HUP0204176A3 (en)
MX (1) MXPA02007198A (en)
PL (1) PL356274A1 (en)
SK (1) SK10932002A3 (en)
WO (1) WO2001055353A2 (en)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2592667C2 (en) * 2010-11-10 2016-07-27 ЗОИТИС ЭлЭлСи North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof

Families Citing this family (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL370541A1 (en) * 2001-03-09 2005-05-30 Boehringer Ingelheim Vetmedica Gmbh Live attenuated strains of prrs virus
US6841364B2 (en) 2002-01-22 2005-01-11 Protatek International, Inc. Infectious cDNA clones of porcine reproductive and respiratory syndrome virus and expression vectors thereof
AU2004223808B2 (en) 2003-03-27 2009-03-26 Ottawa Health Research Institute Mutant vesicular stomatitis viruses and use thereof
JP4320357B2 (en) * 2005-02-25 2009-08-26 ファイザー・プロダクツ・インク N protein variant of porcine genital respiratory syndrome virus
CN100439494C (en) * 2007-03-14 2008-12-03 中国动物疫病预防控制中心 Swine reproduction and respiration syndrome vaccine and its prepn process and application
US7666585B2 (en) 2007-06-15 2010-02-23 Protatek International, Inc. Construction of chimera PRRSV, compositions and vaccine preparations
CN101307305B (en) * 2008-04-30 2010-06-16 中国动物疫病预防控制中心 Low virulent strain of porcine reproductive and respiratory syndrome virus, immunogenicity immunogenicity material and vaccine
CA2943478A1 (en) * 2014-03-21 2015-09-24 Nutech Ventures A non-naturally occuring porcine reproductive and respiratory syndrome virus (prrsv) and methods of using

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US6251397B1 (en) * 1992-10-30 2001-06-26 Iowa State University Research Foundation, Inc. Proteins encoded by polynucleic acids isolated from a porcine reproductive and respiratory syndrome virus and immunogenic compositions containing the same
ES2262142T3 (en) * 1994-08-05 2006-11-16 Regents Of The University Of Minnesota VIRIC SEQUENCE OF NUCLEOTIDES OF VR-2332 AND METHODS OF USE.
EP0839912A1 (en) * 1996-10-30 1998-05-06 Instituut Voor Dierhouderij En Diergezondheid (Id-Dlo) Infectious clones of RNA viruses and vaccines and diagnostic assays derived thereof

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2592667C2 (en) * 2010-11-10 2016-07-27 ЗОИТИС ЭлЭлСи North american porcine reproductive and respiratory syndrome (prrs) virus and uses thereof

Also Published As

Publication number Publication date
CN1406277A (en) 2003-03-26
HUP0204176A2 (en) 2003-04-28
CA2396454A1 (en) 2001-08-02
HUP0204176A3 (en) 2003-12-29
SK10932002A3 (en) 2002-11-06
CZ20022554A3 (en) 2002-10-16
WO2001055353A3 (en) 2001-12-27
EP1254213A2 (en) 2002-11-06
BR0107827A (en) 2002-11-05
MXPA02007198A (en) 2002-12-09
AR027291A1 (en) 2003-03-19
JP2003520601A (en) 2003-07-08
PL356274A1 (en) 2004-06-28
KR20030032910A (en) 2003-04-26
WO2001055353A2 (en) 2001-08-02
AU2001228502A1 (en) 2001-08-07

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