BR0312173A - Mólecula de cdna, molécula e sequência de cdna recombinante, vetor, processo de preparação de partìculas de vìrus do sarampo infeccioso, composição imunogênica, composição de vacina e vìrus mononegaviral recombinante - Google Patents
Mólecula de cdna, molécula e sequência de cdna recombinante, vetor, processo de preparação de partìculas de vìrus do sarampo infeccioso, composição imunogênica, composição de vacina e vìrus mononegaviral recombinanteInfo
- Publication number
- BR0312173A BR0312173A BR0312173-9A BR0312173A BR0312173A BR 0312173 A BR0312173 A BR 0312173A BR 0312173 A BR0312173 A BR 0312173A BR 0312173 A BR0312173 A BR 0312173A
- Authority
- BR
- Brazil
- Prior art keywords
- molecule
- recombinant
- sequence
- vector
- virus
- Prior art date
Links
- 239000000203 mixture Substances 0.000 title abstract 4
- 241000712079 Measles morbillivirus Species 0.000 title abstract 3
- 230000002163 immunogen Effects 0.000 title abstract 3
- 208000015181 infectious disease Diseases 0.000 title abstract 2
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000711513 Mononegavirales Species 0.000 title 1
- 230000002458 infectious effect Effects 0.000 title 1
- 238000004519 manufacturing process Methods 0.000 title 1
- 239000002245 particle Substances 0.000 title 1
- 239000002299 complementary DNA Substances 0.000 abstract 3
- 241000700605 Viruses Species 0.000 abstract 2
- 208000035473 Communicable disease Diseases 0.000 abstract 1
- 230000000890 antigenic effect Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
Classifications
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/165—Mumps or measles virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/12—Mumps virus; Measles virus
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18421—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18441—Use of virus, viral particle or viral elements as a vector
- C12N2760/18443—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10241—Use of virus, viral particle or viral elements as a vector
- C12N2795/10243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
- Molecular Biology (AREA)
- Medicinal Chemistry (AREA)
- Microbiology (AREA)
- Biophysics (AREA)
- Communicable Diseases (AREA)
- Physics & Mathematics (AREA)
- Immunology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Plant Pathology (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Pulmonology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Peptides Or Proteins (AREA)
Abstract
"MOLéCULA DE cDNA, MOLéCULA E SEQuêNCIA DE cDNA RECOMBINANTE, VETOR, PROCESSO DE PREPARAçãO DE PARTìCULAS DE VìRUS DO SARAMPO INFECCIOSO, COMPOSIçãO IMUNOGêNICA, COMPOSIçãO DE VACINA E VìRUS MONONEGAVIRAL RECOMBINANTE". A presente invenção refere-se a uma molécula de cDNA que codifica a seq³ência de nucleotídeos da fita de (+) RNA antigenómica de comprimento total de um vírus do sarampo (MV) que se origina de uma linhagem de vacina aprovada. Ela também se refere à preparação de composições imunogênicas utilizando o mencionado cDNA.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02291551.6 | 2002-06-20 | ||
EP02291551A EP1375512B1 (en) | 2002-06-20 | 2002-06-20 | Infectious cDNA of an approved vaccine strain of measles virus. Use for immunogenic compositions |
PCT/EP2003/007145 WO2004000876A1 (en) | 2002-06-20 | 2003-06-20 | INFECTIOUS cDNA OF AN APPROVED VACCINE STRAIN OF MEASLES VIRUS, USE FOR IMMUNOGENIC COMPOSITIONS |
Publications (3)
Publication Number | Publication Date |
---|---|
BR0312173A true BR0312173A (pt) | 2005-04-05 |
BRPI0312173B1 BRPI0312173B1 (pt) | 2019-05-07 |
BRPI0312173B8 BRPI0312173B8 (pt) | 2021-05-25 |
Family
ID=29716946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BRPI0312173A BRPI0312173B8 (pt) | 2002-06-20 | 2003-06-20 | vetor e processo para a preparação de partículas infecciosas de vírus do sarampo |
Country Status (15)
Country | Link |
---|---|
US (3) | US9005961B2 (pt) |
EP (5) | EP1375512B1 (pt) |
KR (1) | KR101227128B1 (pt) |
CN (1) | CN100577683C (pt) |
AT (1) | ATE437175T1 (pt) |
AU (1) | AU2003266950A1 (pt) |
BR (1) | BRPI0312173B8 (pt) |
CA (1) | CA2489052C (pt) |
CY (1) | CY1109506T1 (pt) |
DE (1) | DE60233038D1 (pt) |
DK (2) | DK1375512T3 (pt) |
ES (2) | ES2330309T3 (pt) |
HK (1) | HK1061568A1 (pt) |
PT (1) | PT1375512E (pt) |
WO (1) | WO2004000876A1 (pt) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1201750A1 (en) | 2000-10-26 | 2002-05-02 | Genopoietic | Synthetic viruses and uses thereof |
EP1375670B1 (en) | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
ES2330309T3 (es) | 2002-06-20 | 2009-12-09 | Institut Pasteur | Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas. |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
US20090004203A1 (en) * | 2007-05-29 | 2009-01-01 | Vical Incorporated | Methods of treating measles infectious disease in mammals |
US8673315B2 (en) * | 2007-11-26 | 2014-03-18 | London School Of Hygiene & Tropical Medicine | Method for producing vaccinal viral strain of a virus of the reoviridae family |
EP2085479A1 (en) * | 2008-01-31 | 2009-08-05 | Institut Pasteur | Reverse genetics of negative-strand rna viruses in yeast |
EP2420242A1 (en) | 2010-08-20 | 2012-02-22 | Lauer, Ulrich M. | Oncolytic measles virus |
EP2780034A1 (en) | 2011-11-14 | 2014-09-24 | Crucell Holland B.V. | Heterologous prime-boost immunization using measles virus-based vaccines |
EP2712871A1 (en) * | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
EP2759301A1 (en) | 2013-01-24 | 2014-07-30 | Institut Pasteur | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
EP2959915A1 (en) | 2014-06-23 | 2015-12-30 | Institut Pasteur | A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection |
EP3103474A1 (en) | 2015-06-12 | 2016-12-14 | Institut Pasteur | Live recombinant measles-m2 virus and its use in eliciting immunity against influenza viruses |
EP3184119A1 (en) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
JP6949468B2 (ja) * | 2016-10-17 | 2021-10-13 | ルプレヒト−カールス−ウニベルジテート ハイデルベルク | 腫瘍抗原をコードする麻疹ウイルス |
EP3622078A1 (en) * | 2017-05-09 | 2020-03-18 | Invectys | Recombinant measles vaccine expressing htert |
EP3412307A1 (en) | 2017-06-07 | 2018-12-12 | Institut Pasteur | Recombinant measles virus expressing zika virus proteins and their applications |
MX2020004833A (es) | 2017-11-09 | 2021-01-08 | Pasteur Institut | Un poliepitopo quimerico del virus del zika que comprende proteinas no estructurales y su uso en una composicion inmunogenica. |
CN111886342A (zh) * | 2017-12-21 | 2020-11-03 | 巴斯德研究所 | 拉沙疫苗 |
CN111218475A (zh) * | 2018-11-23 | 2020-06-02 | 成都生物制品研究所有限责任公司 | 一种拯救麻疹Schwarz/Moraten疫苗株的系统和方法 |
EP4103282A1 (en) * | 2020-02-13 | 2022-12-21 | Institut Pasteur | Measles-vectored covid-19 immunogenic compositions and vaccines |
EP3865180A1 (en) * | 2020-02-13 | 2021-08-18 | Institut Pasteur | Live recombinant measles virus expressing coronavirus antigens - its use in eliciting immunity against coronaviruses |
EP3936517A1 (en) | 2020-07-08 | 2022-01-12 | Institut Pasteur | An improved measles virus vaccine vector based on multiple tandem additional transcription units |
US20240093233A1 (en) | 2021-01-13 | 2024-03-21 | Viroxis | Measles-hiv or measles-htlv vaccine |
CN113293148B (zh) * | 2021-03-10 | 2022-10-25 | 上海青赛生物科技有限公司 | 一种h基因替换的嵌合麻疹减毒株的构建 |
EP4310186A1 (en) * | 2021-03-15 | 2024-01-24 | Misako Yoneda | Recombinant measles virus |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
JP3045581B2 (ja) * | 1991-10-14 | 2000-05-29 | 社団法人北里研究所 | 麻疹ワクチンウイルス株同定方法 |
EP0780475B2 (en) * | 1995-08-09 | 2006-07-19 | SCHWEIZ. SERUM- & IMPFINSTITUT BERN | Process for the production of infectious negative-strand RNA viruses |
WO1998013501A2 (en) * | 1996-09-27 | 1998-04-02 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales |
IL131600A0 (en) | 1997-02-28 | 2001-01-28 | Ora Vax Inc | Chimeric flavivirus vaccines |
BRPI9701774B8 (pt) * | 1997-04-11 | 2015-09-29 | Fundação Oswaldo Cruz Fiocruz | cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela. |
US6410023B1 (en) * | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
AU767193B2 (en) * | 1998-03-26 | 2003-11-06 | Wyeth Holdings Corporation | Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup B |
KR100579662B1 (ko) * | 1998-06-03 | 2006-05-12 | 와이어쓰 홀딩스 코포레이션 | 리보핵산 바이러스의 신규 구제방법 |
US6146642A (en) * | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
WO2001009309A2 (en) | 1999-08-02 | 2001-02-08 | American Home Products Corporation | RESCUE OF MUMPS VIRUS FROM cDNA |
NZ521840A (en) * | 2000-04-28 | 2004-11-26 | St | Development of a multi-plasmid pol I - pol II based system for the generation of infectious influenza RNA viruses from cloned DNA |
ES2330309T3 (es) * | 2002-06-20 | 2009-12-09 | Institut Pasteur | Adnc infeccioso de una cepa de vacuna aprobada de virus del sarampion. uso para composiciones inmunogenicas. |
EP1375670B1 (en) * | 2002-06-20 | 2013-06-12 | Institut Pasteur | Recombinant measles viruses expressing epitopes of antigens of RNA viruses and use of the recombinant viruses for the preparation of vaccine compositions |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
EP1939214B1 (en) | 2006-12-22 | 2013-07-10 | Institut Pasteur | Cells and methodology to generate non-segmented negative-strand RNA viruses |
EA027784B1 (ru) * | 2008-05-26 | 2017-09-29 | Кадила Хелзкэр Лимитед | Комбинированная вакцина против кори и вируса папилломы человека |
SG175846A1 (en) * | 2009-05-05 | 2011-12-29 | Cadila Healthcare Ltd | Combined measles-malaria vaccine |
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2002
- 2002-06-20 ES ES02291551T patent/ES2330309T3/es not_active Expired - Lifetime
- 2002-06-20 PT PT02291551T patent/PT1375512E/pt unknown
- 2002-06-20 EP EP02291551A patent/EP1375512B1/en not_active Expired - Lifetime
- 2002-06-20 DK DK02291551T patent/DK1375512T3/da active
- 2002-06-20 DE DE60233038T patent/DE60233038D1/de not_active Expired - Lifetime
- 2002-06-20 AT AT02291551T patent/ATE437175T1/de active
- 2002-06-20 EP EP09165802A patent/EP2110382A1/en not_active Withdrawn
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2003
- 2003-06-20 EP EP10184511.3A patent/EP2311853B1/en not_active Expired - Lifetime
- 2003-06-20 EP EP08169719A patent/EP2065393A1/en not_active Withdrawn
- 2003-06-20 EP EP03747858A patent/EP1513872A1/en not_active Ceased
- 2003-06-20 BR BRPI0312173A patent/BRPI0312173B8/pt active IP Right Grant
- 2003-06-20 WO PCT/EP2003/007145 patent/WO2004000876A1/en not_active Application Discontinuation
- 2003-06-20 DK DK10184511.3T patent/DK2311853T3/en active
- 2003-06-20 KR KR1020047020803A patent/KR101227128B1/ko active IP Right Grant
- 2003-06-20 CN CN03814471A patent/CN100577683C/zh not_active Expired - Lifetime
- 2003-06-20 CA CA2489052A patent/CA2489052C/en not_active Expired - Lifetime
- 2003-06-20 ES ES10184511.3T patent/ES2663224T3/es not_active Expired - Lifetime
- 2003-06-20 AU AU2003266950A patent/AU2003266950A1/en not_active Abandoned
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2004
- 2004-06-16 HK HK04104400.2A patent/HK1061568A1/xx not_active IP Right Cessation
- 2004-12-17 US US11/013,786 patent/US9005961B2/en active Active
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2008
- 2008-07-24 US US12/219,570 patent/US9005925B2/en active Active
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2009
- 2009-09-18 CY CY20091100970T patent/CY1109506T1/el unknown
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2015
- 2015-03-24 US US14/667,088 patent/US9701944B2/en not_active Expired - Lifetime
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