BRPI9701774B8 - cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela. - Google Patents

cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.

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Publication number
BRPI9701774B8
BRPI9701774B8 BRPI9701774A BR9701774A BRPI9701774B8 BR PI9701774 B8 BRPI9701774 B8 BR PI9701774B8 BR PI9701774 A BRPI9701774 A BR PI9701774A BR 9701774 A BR9701774 A BR 9701774A BR PI9701774 B8 BRPI9701774 B8 BR PI9701774B8
Authority
BR
Brazil
Prior art keywords
yellow fever
fever virus
infectious
virus
cdna
Prior art date
Application number
BRPI9701774A
Other languages
English (en)
Other versions
BRPI9701774B1 (pt
BR9701774A (pt
Inventor
Marcos Da Silva Freire
Ricardo Galler
Original Assignee
Fundação Oswaldo Cruz Fiocruz
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Fundação Oswaldo Cruz Fiocruz filed Critical Fundação Oswaldo Cruz Fiocruz
Priority to BRPI9701774A priority Critical patent/BRPI9701774B8/pt
Priority to ZA982760A priority patent/ZA982760B/xx
Priority to CA002233932A priority patent/CA2233932C/en
Priority to EP98106495A priority patent/EP0877086B1/en
Priority to DE69839169T priority patent/DE69839169T2/de
Priority to OA9800041A priority patent/OA10791A/en
Priority to US09/058,411 priority patent/US6171854B1/en
Priority to RU98106999/13A priority patent/RU98106999A/ru
Priority to CU1998046A priority patent/CU22770A3/es
Publication of BR9701774A publication Critical patent/BR9701774A/pt
Priority to US09/705,949 priority patent/US6589522B1/en
Publication of BRPI9701774B1 publication Critical patent/BRPI9701774B1/pt
Publication of BRPI9701774B8 publication Critical patent/BRPI9701774B8/pt

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24121—Viruses as such, e.g. new isolates, mutants or their genomic sequences
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N2770/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses positive-sense
    • C12N2770/00011—Details
    • C12N2770/24011—Flaviviridae
    • C12N2770/24111—Flavivirus, e.g. yellow fever virus, dengue, JEV
    • C12N2770/24122—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Genetics & Genomics (AREA)
  • Virology (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Biochemistry (AREA)
  • Molecular Biology (AREA)
  • Biotechnology (AREA)
  • Immunology (AREA)
  • General Engineering & Computer Science (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Biomedical Technology (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • General Chemical & Material Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)

Abstract

patente de invenção <b>"vacinas contra infecções causadas pelo vírus da febre amarela, cdna infeccioso de febre amarela, método para produzir um vírus recombinante de febre amarela a partir do cdna infeccioso de febre amarela e plasmídeos para formar o cdna infeccioso de febre amarela"<d> a presente invenção refere-se a vacina humana contra infecções causadas pelo vírus da febre amarela consistindo essencialmente de vírus recombinante de febre amarela yfiv5.2/dd regenerado a partir do cdna infeccioso de vírus da febre amarela. os plasmídeos pyf5'3'iv/g1/2 e pyfm5.2/t3/27, em conjunto contém a sequência completa do dito cdna infeccioso. o método para a produção do vírus yfiv5.2/dd e o lotes semente original, primário e secundário compreendendo o vírus yfiv5.2/dd são outras concretizações da presente invenção.
BRPI9701774A 1997-04-11 1997-04-11 cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela. BRPI9701774B8 (pt)

Priority Applications (10)

Application Number Priority Date Filing Date Title
BRPI9701774A BRPI9701774B8 (pt) 1997-04-11 1997-04-11 cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.
ZA982760A ZA982760B (en) 1997-04-11 1998-04-01 Vaccines against infections caused by YF virus YF infectious cDNA method for producing a recombinant YF virus from the YF infectious cDNA and plasmids to assemble the YF infectious cDNA
CA002233932A CA2233932C (en) 1997-04-11 1998-04-07 Vaccines against infections caused by yf virus; yf infectious cdna, method for producing a recombinant yf virus from the yf infectious cdna and plasmids to assemble the yf infectious cdna
EP98106495A EP0877086B1 (en) 1997-04-11 1998-04-08 Recombinant YF virus vaccines recovered from the infectious cDNA
DE69839169T DE69839169T2 (de) 1997-04-11 1998-04-08 Aus infektiöser cDNA gewonnene rekombinate YF Viren-Impfstoffe
OA9800041A OA10791A (en) 1997-04-11 1998-04-09 Vaccines against infections caused by yf virus yf infectious cdna method for producing a recombinantyf virus from the yf infectious cdna and plasmids to assemble the yf infectious cdna
US09/058,411 US6171854B1 (en) 1997-04-11 1998-04-10 Yellow fever infectious cDNA and plasmids
RU98106999/13A RU98106999A (ru) 1997-04-11 1998-04-10 Вакцины против инфекций, вызываемых yf вирусом; yf инфекционные кднк, способ получения рекомбинантного yf вируса из yf инфекционных кднк и плазмиды для сборки yf инфекционных кднк
CU1998046A CU22770A3 (es) 1997-04-11 1998-04-10 Vacunas contra infecciones causadas por el virus de la fiebre amarilla. método para producir un virus recombinante de fiebre amarilla a partir del dnac infeccioso de fiebre amarilla y plásmidos para formar el dnac infeccioso de fiebre amarilla
US09/705,949 US6589522B1 (en) 1997-04-11 2000-11-06 Vaccines against infections caused by YF virus; YF infectious cDNA, method for producing a recombinant YF virus from the YF infectious cDNA and plasmids to assemble the YF infectious cDNA

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
BRPI9701774A BRPI9701774B8 (pt) 1997-04-11 1997-04-11 cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.

Publications (3)

Publication Number Publication Date
BR9701774A BR9701774A (pt) 2000-08-01
BRPI9701774B1 BRPI9701774B1 (pt) 2015-08-25
BRPI9701774B8 true BRPI9701774B8 (pt) 2015-09-29

Family

ID=4066904

Family Applications (1)

Application Number Title Priority Date Filing Date
BRPI9701774A BRPI9701774B8 (pt) 1997-04-11 1997-04-11 cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.

Country Status (9)

Country Link
US (2) US6171854B1 (pt)
EP (1) EP0877086B1 (pt)
BR (1) BRPI9701774B8 (pt)
CA (1) CA2233932C (pt)
CU (1) CU22770A3 (pt)
DE (1) DE69839169T2 (pt)
OA (1) OA10791A (pt)
RU (1) RU98106999A (pt)
ZA (1) ZA982760B (pt)

Families Citing this family (25)

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Publication number Priority date Publication date Assignee Title
US6962708B1 (en) * 1997-02-28 2005-11-08 Acambis, Inc. Chimeric flavivirus vaccines
BRPI9701774B8 (pt) 1997-04-11 2015-09-29 Fundação Oswaldo Cruz Fiocruz cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.
DE19757301A1 (de) 1997-12-22 1999-06-24 Deutsches Primatenzentrum Gmbh Intra-nasale Gelbfieber-Impfung
US6541011B2 (en) * 1998-02-11 2003-04-01 Maxygen, Inc. Antigen library immunization
GB2372991B (en) * 2001-03-09 2004-11-17 Fiocruz Fundacao Oswaldo Cruz Flavivirus expression vector
BR0210907A (pt) * 2001-06-01 2004-12-21 Acambis Inc Vetores de flavivìrus quiméricos
US20050002968A1 (en) * 2002-01-15 2005-01-06 Monath Thomas P. Flavivirus vaccines
AU2003267937C1 (en) 2002-01-15 2019-08-08 Sanofi Pasteur Biologics, Llc Flavivirus vaccines
WO2003101397A2 (en) * 2002-05-31 2003-12-11 Acambis, Inc. Tetravalent dengue vaccines
PT1375512E (pt) * 2002-06-20 2009-09-23 Pasteur Institut Adnc infeccioso de uma estirpe de vacina aprovada do vírus do sarampo. utilização de composições imunogénicas
WO2004009764A2 (en) * 2002-07-19 2004-01-29 Board Of Regents, The University Of Texas System Methods and compositions concerning altered yellow fever virus strains
US7785799B2 (en) * 2002-08-16 2010-08-31 The Board Of Regents Of The University Of Texas System Compositions and methods related to flavivirus envelope protein domain III antigens
JP4683926B2 (ja) * 2002-11-15 2011-05-18 サノフィ パスツール バイオロジクス カンパニー ウエストナイルウイルス・ワクチン
EP1784487B1 (en) 2004-07-27 2011-08-24 THE GOVERNMENT OF THE UNITED STATES OF AMERICA as represented by THE SECRETARY OF THE DEPARTMENT OF HEALTH AND HUMAN SERVICES Identification of cross-reactive epitopes of flavivirus envelope glycoprotein
BRPI0504945B8 (pt) 2005-10-31 2022-08-02 Fundacao Oswaldo Cruz Método para a produção de flavivirus recombinante contendo sequências de nucleotídeos codificantes de uma proteína heteróloga, constructo de dna, flavivirus, e, composição vacinal para imunizar contra flavivirus e/ou outros patógenos.
CN102280898B (zh) 2006-06-30 2014-11-12 Abb技术有限公司 控制高压直流系统中的电压源变换器的方法和变换器站
US7872560B2 (en) * 2007-03-19 2011-01-18 Abc Taiwan Electronics Corp. Independent planar transformer
EP1982727A1 (en) * 2007-04-17 2008-10-22 Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. Method for purification of viral proteins
DK2200588T3 (da) * 2007-09-25 2019-07-01 Solubest Ltd Sammensætninger, som omfatter lipofile aktive forbindelser, og fremgangsmåde til fremstilling deraf
JP5689687B2 (ja) 2008-03-05 2015-03-25 サノフィ・パスツールＳａｎｏｆｉｐａｓｔｅｕｒ アジュバント含有ワクチン組成物の安定化方法
EP2143440A1 (fr) 2008-07-09 2010-01-13 Sanofi Pasteur Agent stabilisant et composition vaccinale comprenant un ou plusieurs flavivirus vivants atténués
EP2977457B1 (en) 2008-07-17 2021-09-01 Medigen, Inc. Idna vaccines and methods for using the same
BRPI0904020B8 (pt) 2009-10-01 2021-05-25 Fundacao Oswaldo Cruz composição vacinal contra o vírus da dengue, e, kit
BRPI0905645B8 (pt) * 2009-10-27 2021-05-25 Fundacao Oswaldo Cruz vacina de dna contra o vírus da febre amarela
US11459619B2 (en) 2016-02-08 2022-10-04 The Johns Hopkins University Handheld nucleic acid-based assay for rapid identification

Family Cites Families (3)

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Publication number Priority date Publication date Assignee Title
US4719177A (en) 1981-04-20 1988-01-12 Massachusetts Institute Of Technology Production of complementary DNA representing RNA viral sequences by recombinant DNA methods and uses therefor
CA2116980C (en) 1991-09-19 2006-06-06 Ching-Juh Lai Chimeric and/or growth-restricted flaviviruses
BRPI9701774B8 (pt) 1997-04-11 2015-09-29 Fundação Oswaldo Cruz Fiocruz cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela.

Also Published As

Publication number Publication date
US6171854B1 (en) 2001-01-09
CU22770A3 (es) 2002-07-24
CA2233932C (en) 2009-01-13
CA2233932A1 (en) 1998-10-11
BRPI9701774B1 (pt) 2015-08-25
RU98106999A (ru) 2000-02-20
US6589522B1 (en) 2003-07-08
DE69839169T2 (de) 2009-03-19
EP0877086B1 (en) 2008-02-27
ZA982760B (en) 1999-01-18
OA10791A (en) 2002-12-24
BR9701774A (pt) 2000-08-01
DE69839169D1 (de) 2008-04-10
EP0877086A2 (en) 1998-11-11
EP0877086A3 (en) 1999-09-01

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