CY1109506T1 - ΛΟΙΜΟΓΟΝΟ cDNA ΕΝΟΣ ΕΓΚΕΚΡΙΜΕΝΟΥ ΣΤΕΛΕΧΟΥΣ ΕΜΒΟΛΙΟΥ ΤΟΥ ΙΟΥ ΤΗΣ ΙΛΑΡΑΣ. ΧΡΗΣΗ ΓΙΑ ΑΝΟΣΟΓΟΝΕΣ ΣΥΝΘΕΣΕΙΣ - Google Patents
ΛΟΙΜΟΓΟΝΟ cDNA ΕΝΟΣ ΕΓΚΕΚΡΙΜΕΝΟΥ ΣΤΕΛΕΧΟΥΣ ΕΜΒΟΛΙΟΥ ΤΟΥ ΙΟΥ ΤΗΣ ΙΛΑΡΑΣ. ΧΡΗΣΗ ΓΙΑ ΑΝΟΣΟΓΟΝΕΣ ΣΥΝΘΕΣΕΙΣInfo
- Publication number
- CY1109506T1 CY1109506T1 CY20091100970T CY091100970T CY1109506T1 CY 1109506 T1 CY1109506 T1 CY 1109506T1 CY 20091100970 T CY20091100970 T CY 20091100970T CY 091100970 T CY091100970 T CY 091100970T CY 1109506 T1 CY1109506 T1 CY 1109506T1
- Authority
- CY
- Cyprus
- Prior art keywords
- approved
- measles virus
- vaccine strain
- immune
- synthesis
- Prior art date
Links
- 239000002299 complementary DNA Substances 0.000 title abstract 3
- 229940124862 Measles virus vaccine Drugs 0.000 title 1
- 230000015572 biosynthetic process Effects 0.000 title 1
- 201000010099 disease Diseases 0.000 title 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 title 1
- 238000003786 synthesis reaction Methods 0.000 title 1
- 241000712079 Measles morbillivirus Species 0.000 abstract 2
- 230000002163 immunogen Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 229960005486 vaccine Drugs 0.000 abstract 1
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- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
- A61K39/165—Mumps or measles virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
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- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
- C07K14/08—RNA viruses
- C07K14/115—Paramyxoviridae, e.g. parainfluenza virus
- C07K14/12—Mumps virus; Measles virus
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- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K39/00—Medicinal preparations containing antigens or antibodies
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18421—Viruses as such, e.g. new isolates, mutants or their genomic sequences
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- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18422—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18434—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
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- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
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- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18411—Morbillivirus, e.g. Measles virus, canine distemper
- C12N2760/18441—Use of virus, viral particle or viral elements as a vector
- C12N2760/18443—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- C12N2795/00—Bacteriophages
- C12N2795/00011—Details
- C12N2795/10011—Details dsDNA Bacteriophages
- C12N2795/10211—Podoviridae
- C12N2795/10241—Use of virus, viral particle or viral elements as a vector
- C12N2795/10243—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- General Health & Medical Sciences (AREA)
- Biomedical Technology (AREA)
- Biotechnology (AREA)
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- General Engineering & Computer Science (AREA)
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- Medicinal Chemistry (AREA)
- Microbiology (AREA)
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- Gastroenterology & Hepatology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Immunology (AREA)
- Plant Pathology (AREA)
- Pharmacology & Pharmacy (AREA)
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- Animal Behavior & Ethology (AREA)
- Oncology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
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- Chemical Kinetics & Catalysis (AREA)
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- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
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Abstract
Η εφεύρεση σχετίζεται με ένα μόριο cDNA του οποίου εγκωδικεύει την αλληλουχία νουκλεοτιδίων του αντιγονιδιωματικού κλώνου (+)RNA πλήρους μήκους ενός ιού ιλαράς (MV) που προέρχεται από ένα εγκεκριμένο στέλεχος εμβολίου. Αφορά επίσης την παρασκευή ανοσογόνων συνθέσεων χρησιμοποιώντας το εν λόγω cDNA.
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
EP02291551A EP1375512B1 (en) | 2002-06-20 | 2002-06-20 | Infectious cDNA of an approved vaccine strain of measles virus. Use for immunogenic compositions |
Publications (1)
Publication Number | Publication Date |
---|---|
CY1109506T1 true CY1109506T1 (el) | 2014-08-13 |
Family
ID=29716946
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
CY20091100970T CY1109506T1 (el) | 2002-06-20 | 2009-09-18 | ΛΟΙΜΟΓΟΝΟ cDNA ΕΝΟΣ ΕΓΚΕΚΡΙΜΕΝΟΥ ΣΤΕΛΕΧΟΥΣ ΕΜΒΟΛΙΟΥ ΤΟΥ ΙΟΥ ΤΗΣ ΙΛΑΡΑΣ. ΧΡΗΣΗ ΓΙΑ ΑΝΟΣΟΓΟΝΕΣ ΣΥΝΘΕΣΕΙΣ |
Country Status (15)
Country | Link |
---|---|
US (3) | US9005961B2 (el) |
EP (5) | EP2110382A1 (el) |
KR (1) | KR101227128B1 (el) |
CN (1) | CN100577683C (el) |
AT (1) | ATE437175T1 (el) |
AU (1) | AU2003266950A1 (el) |
BR (1) | BRPI0312173B8 (el) |
CA (1) | CA2489052C (el) |
CY (1) | CY1109506T1 (el) |
DE (1) | DE60233038D1 (el) |
DK (2) | DK1375512T3 (el) |
ES (2) | ES2330309T3 (el) |
HK (1) | HK1061568A1 (el) |
PT (1) | PT1375512E (el) |
WO (1) | WO2004000876A1 (el) |
Families Citing this family (27)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP1201750A1 (en) | 2000-10-26 | 2002-05-02 | Genopoietic | Synthetic viruses and uses thereof |
ATE437175T1 (de) * | 2002-06-20 | 2009-08-15 | Pasteur Institut | Infektiöse cdna eines zugelassenen impfstammes des masern virus. verwendung in immunogenen zusammensetzungen |
ES2427139T3 (es) * | 2002-06-20 | 2013-10-29 | Institut Pasteur | Virus recombinantes del sarampión que expresan epítopos de antígenos de virus de ARN y uso de los virus recombinantes para la preparación de composiciones de vacuna |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
WO2009005917A2 (en) * | 2007-05-29 | 2009-01-08 | Vical Incorporated | Methods of treating measles infectious disease in mammals |
EP3037526B1 (en) * | 2007-11-26 | 2018-03-14 | London School of Hygiene and Tropical Medicine | Method for producing vaccinal viral strain of a virus of the reoviridae family |
EP2085479A1 (en) * | 2008-01-31 | 2009-08-05 | Institut Pasteur | Reverse genetics of negative-strand rna viruses in yeast |
EP2420242A1 (en) | 2010-08-20 | 2012-02-22 | Lauer, Ulrich M. | Oncolytic measles virus |
US20130122038A1 (en) | 2011-11-14 | 2013-05-16 | The United States Of America As Represented By The Secretary Of The Department | Heterologous prime-boost immunization using measles virus-based vaccines |
EP2712871A1 (en) | 2012-09-27 | 2014-04-02 | Institut Pasteur | Recombinant Measles virus expressing Chikungunya virus polypeptides and their applications |
EP2759301A1 (en) | 2013-01-24 | 2014-07-30 | Institut Pasteur | Use of a genetically modified infectious measles virus with enhanced pro-apoptotic properties (MV-DeltaC virus) |
WO2015092710A1 (en) | 2013-12-19 | 2015-06-25 | Glaxosmithkline Biologicals, S.A. | Contralateral co-administration of vaccines |
EP2959915A1 (en) | 2014-06-23 | 2015-12-30 | Institut Pasteur | A dengue virus chimeric polyepitope composed of fragments of non-structural proteins and its use in an immunogenic composition against dengue virus infection |
EP3103474A1 (en) * | 2015-06-12 | 2016-12-14 | Institut Pasteur | Live recombinant measles-m2 virus and its use in eliciting immunity against influenza viruses |
EP3184119A1 (en) | 2015-12-23 | 2017-06-28 | Themis Bioscience GmbH | Chromatography based purification strategies for measles scaffold based viruses |
JP6949468B2 (ja) * | 2016-10-17 | 2021-10-13 | ルプレヒト−カールス−ウニベルジテート ハイデルベルク | 腫瘍抗原をコードする麻疹ウイルス |
WO2018206512A1 (en) * | 2017-05-09 | 2018-11-15 | Invectys | Recombinant measles vaccine expressing htert |
EP3412307A1 (en) | 2017-06-07 | 2018-12-12 | Institut Pasteur | Recombinant measles virus expressing zika virus proteins and their applications |
EP3707154A1 (en) | 2017-11-09 | 2020-09-16 | Institut Pasteur | A zika virus chimeric polyepitope comprising non-structural proteins and its use in an immunogenic composition |
SG11202004899SA (en) * | 2017-12-21 | 2020-06-29 | Pasteur Institut | Lassa vaccine |
CN111218475A (zh) * | 2018-11-23 | 2020-06-02 | 成都生物制品研究所有限责任公司 | 一种拯救麻疹Schwarz/Moraten疫苗株的系统和方法 |
KR20220141332A (ko) * | 2020-02-13 | 2022-10-19 | 앵스티띠 파스퇴르 | 홍역-벡터화된 covid-19 면역원성 조성물 및 백신 |
EP3865180A1 (en) * | 2020-02-13 | 2021-08-18 | Institut Pasteur | Live recombinant measles virus expressing coronavirus antigens - its use in eliciting immunity against coronaviruses |
EP3936517A1 (en) | 2020-07-08 | 2022-01-12 | Institut Pasteur | An improved measles virus vaccine vector based on multiple tandem additional transcription units |
AU2022208199A1 (en) | 2021-01-13 | 2023-07-13 | Centre National De La Recherche Scientifique | Measles-hiv or measles-htlv vaccine |
CN113293148B (zh) * | 2021-03-10 | 2022-10-25 | 上海青赛生物科技有限公司 | 一种h基因替换的嵌合麻疹减毒株的构建 |
WO2022195900A1 (ja) * | 2021-03-15 | 2022-09-22 | 国立大学法人東京大学 | 組換え麻疹ウイルス |
Family Cites Families (19)
Publication number | Priority date | Publication date | Assignee | Title |
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AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
JP3045581B2 (ja) | 1991-10-14 | 2000-05-29 | 社団法人北里研究所 | 麻疹ワクチンウイルス株同定方法 |
DE69510207T3 (de) * | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
CA2265554A1 (en) * | 1996-09-27 | 1998-04-02 | American Cyanamid Company | 3' genomic promoter region and polymerase gene mutations responsible for attenuation in viruses of the order designated mononegavirales |
JP4504464B2 (ja) | 1997-02-28 | 2010-07-14 | サノフィ パスツール バイオロジクス カンパニー | キメラフラビウイルスワクチン |
BRPI9701774B8 (pt) * | 1997-04-11 | 2015-09-29 | Fundação Oswaldo Cruz Fiocruz | cdna mutante e infeccioso do vírus da febre amarela, constructo de dna, vírus recombinante de febre amarela e vacina para humanos contra infecções de febre amarela. |
US6410023B1 (en) * | 1997-05-23 | 2002-06-25 | United States Of America | Recombinant parainfluenza virus vaccines attenuated by deletion or ablation of a non-essential gene |
KR20010080863A (ko) * | 1998-03-26 | 2001-08-25 | 윌리암 에이취 캘넌, 에곤 이 버그 | 마진 바이러스 또는 인간 호흡기 합포체 바이러스서브그룹 비에서 감쇠 담당 돌연변이 |
WO1999063064A1 (en) * | 1998-06-03 | 1999-12-09 | American Cyanamid Company | Novel methods for rescue of rna viruses |
US6146642A (en) | 1998-09-14 | 2000-11-14 | Mount Sinai School Of Medicine, Of The City University Of New York | Recombinant new castle disease virus RNA expression systems and vaccines |
KR100884673B1 (ko) | 1999-08-02 | 2009-02-18 | 와이어쓰 | 씨디엔에이로부터 멈프스 바이러스의 구제 |
HU229101B1 (en) * | 2000-04-28 | 2013-07-29 | St Jude Childrens Res Hospital | Dna transfection system for the generation of infectious influenza virus |
ES2427139T3 (es) | 2002-06-20 | 2013-10-29 | Institut Pasteur | Virus recombinantes del sarampión que expresan epítopos de antígenos de virus de ARN y uso de los virus recombinantes para la preparación de composiciones de vacuna |
ATE437175T1 (de) * | 2002-06-20 | 2009-08-15 | Pasteur Institut | Infektiöse cdna eines zugelassenen impfstammes des masern virus. verwendung in immunogenen zusammensetzungen |
CA2432738A1 (en) | 2003-02-26 | 2004-08-26 | Philippe Despres | New dengue and west nile viruses proteins and genes coding the foregoing, and their use in vaccinal, therapeutic and diagnostic applications |
CA2508266A1 (fr) | 2005-06-20 | 2006-12-20 | Institut Pasteur | Polypeptides chimeriques et leurs applications therapeutiques contre une infection a flaviviridae |
DK1939214T3 (da) | 2006-12-22 | 2013-10-14 | Pasteur Institut | Celler og metodik til at generere ikke-segmenterede negativstrengede RNA-vira |
EA027784B1 (ru) * | 2008-05-26 | 2017-09-29 | Кадила Хелзкэр Лимитед | Комбинированная вакцина против кори и вируса папилломы человека |
UA104180C2 (uk) * | 2009-05-05 | 2014-01-10 | Каділа Хелткере Лімітед | Комбінована вакцина проти кору та малярії |
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2002
- 2002-06-20 AT AT02291551T patent/ATE437175T1/de active
- 2002-06-20 DK DK02291551T patent/DK1375512T3/da active
- 2002-06-20 PT PT02291551T patent/PT1375512E/pt unknown
- 2002-06-20 EP EP09165802A patent/EP2110382A1/en not_active Withdrawn
- 2002-06-20 EP EP02291551A patent/EP1375512B1/en not_active Expired - Lifetime
- 2002-06-20 DE DE60233038T patent/DE60233038D1/de not_active Expired - Lifetime
- 2002-06-20 ES ES02291551T patent/ES2330309T3/es not_active Expired - Lifetime
-
2003
- 2003-06-20 EP EP03747858A patent/EP1513872A1/en not_active Ceased
- 2003-06-20 CA CA2489052A patent/CA2489052C/en not_active Expired - Lifetime
- 2003-06-20 ES ES10184511.3T patent/ES2663224T3/es not_active Expired - Lifetime
- 2003-06-20 CN CN03814471A patent/CN100577683C/zh not_active Expired - Lifetime
- 2003-06-20 WO PCT/EP2003/007145 patent/WO2004000876A1/en not_active Application Discontinuation
- 2003-06-20 AU AU2003266950A patent/AU2003266950A1/en not_active Abandoned
- 2003-06-20 EP EP10184511.3A patent/EP2311853B1/en not_active Expired - Lifetime
- 2003-06-20 KR KR1020047020803A patent/KR101227128B1/ko active IP Right Grant
- 2003-06-20 EP EP08169719A patent/EP2065393A1/en not_active Withdrawn
- 2003-06-20 DK DK10184511.3T patent/DK2311853T3/en active
- 2003-06-20 BR BRPI0312173A patent/BRPI0312173B8/pt active IP Right Grant
-
2004
- 2004-06-16 HK HK04104400.2A patent/HK1061568A1/xx not_active IP Right Cessation
- 2004-12-17 US US11/013,786 patent/US9005961B2/en active Active
-
2008
- 2008-07-24 US US12/219,570 patent/US9005925B2/en active Active
-
2009
- 2009-09-18 CY CY20091100970T patent/CY1109506T1/el unknown
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2015
- 2015-03-24 US US14/667,088 patent/US9701944B2/en not_active Expired - Lifetime
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