ATE419369T1 - Chimäre mensch-rinder respiratory syncytial virus vakzinen - Google Patents
Chimäre mensch-rinder respiratory syncytial virus vakzinenInfo
- Publication number
- ATE419369T1 ATE419369T1 AT00941756T AT00941756T ATE419369T1 AT E419369 T1 ATE419369 T1 AT E419369T1 AT 00941756 T AT00941756 T AT 00941756T AT 00941756 T AT00941756 T AT 00941756T AT E419369 T1 ATE419369 T1 AT E419369T1
- Authority
- AT
- Austria
- Prior art keywords
- rsv
- genome
- human
- chimeric
- bovine
- Prior art date
Links
- 241000725643 Respiratory syncytial virus Species 0.000 title abstract 7
- 229960005486 vaccine Drugs 0.000 title abstract 2
- 241000711895 Bovine orthopneumovirus Species 0.000 abstract 2
- 241000711920 Human orthopneumovirus Species 0.000 abstract 2
- 108090000623 proteins and genes Proteins 0.000 abstract 2
- 241000282412 Homo Species 0.000 abstract 1
- 241000124008 Mammalia Species 0.000 abstract 1
- 230000002238 attenuated effect Effects 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000009472 formulation Methods 0.000 abstract 1
- 230000028993 immune response Effects 0.000 abstract 1
- 208000015181 infectious disease Diseases 0.000 abstract 1
- 230000002458 infectious effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000004048 modification Effects 0.000 abstract 1
- 238000012986 modification Methods 0.000 abstract 1
- 230000035772 mutation Effects 0.000 abstract 1
- 239000002773 nucleotide Substances 0.000 abstract 1
- 125000003729 nucleotide group Chemical group 0.000 abstract 1
- 239000002157 polynucleotide Substances 0.000 abstract 1
- 102000040430 polynucleotide Human genes 0.000 abstract 1
- 108091033319 polynucleotide Proteins 0.000 abstract 1
- 239000013598 vector Substances 0.000 abstract 1
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N7/00—Viruses; Bacteriophages; Compositions thereof; Preparation or purification thereof
- C12N7/04—Inactivation or attenuation; Producing viral sub-units
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
- A61K39/155—Paramyxoviridae, e.g. parainfluenza virus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P11/00—Drugs for disorders of the respiratory system
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/005—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from viruses
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/86—Viral vectors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5254—Virus avirulent or attenuated
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/51—Medicinal preparations containing antigens or antibodies comprising whole cells, viruses or DNA/RNA
- A61K2039/525—Virus
- A61K2039/5256—Virus expressing foreign proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
- A61K2039/541—Mucosal route
- A61K2039/544—Mucosal route to the airways
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K2319/00—Fusion polypeptide
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18522—New viral proteins or individual genes, new structural or functional aspects of known viral proteins or genes
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18534—Use of virus or viral component as vaccine, e.g. live-attenuated or inactivated virus, VLP, viral protein
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18541—Use of virus, viral particle or viral elements as a vector
- C12N2760/18543—Use of virus, viral particle or viral elements as a vector viral genome or elements thereof as genetic vector
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2760/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA ssRNA viruses negative-sense
- C12N2760/00011—Details
- C12N2760/18011—Paramyxoviridae
- C12N2760/18511—Pneumovirus, e.g. human respiratory syncytial virus
- C12N2760/18561—Methods of inactivation or attenuation
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N2840/00—Vectors comprising a special translation-regulating system
- C12N2840/20—Vectors comprising a special translation-regulating system translation of more than one cistron
- C12N2840/203—Vectors comprising a special translation-regulating system translation of more than one cistron having an IRES
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Genetics & Genomics (AREA)
- Organic Chemistry (AREA)
- Engineering & Computer Science (AREA)
- Virology (AREA)
- General Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Zoology (AREA)
- Medicinal Chemistry (AREA)
- Wood Science & Technology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- General Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Biomedical Technology (AREA)
- Veterinary Medicine (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Molecular Biology (AREA)
- Biophysics (AREA)
- Pulmonology (AREA)
- Plant Pathology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Gastroenterology & Hepatology (AREA)
- Physics & Mathematics (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US14313299P | 1999-07-09 | 1999-07-09 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE419369T1 true ATE419369T1 (de) | 2009-01-15 |
Family
ID=22502738
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT00941756T ATE419369T1 (de) | 1999-07-09 | 2000-06-23 | Chimäre mensch-rinder respiratory syncytial virus vakzinen |
Country Status (13)
Country | Link |
---|---|
US (2) | US7829102B2 (de) |
EP (1) | EP1287152B1 (de) |
JP (1) | JP2003530073A (de) |
KR (1) | KR100905450B1 (de) |
CN (2) | CN100354425C (de) |
AT (1) | ATE419369T1 (de) |
AU (2) | AU784216B2 (de) |
BR (1) | BR0013195A (de) |
CA (1) | CA2378552A1 (de) |
DE (1) | DE60041280D1 (de) |
IL (2) | IL147447A0 (de) |
MX (1) | MXPA02000220A (de) |
WO (1) | WO2001004335A2 (de) |
Families Citing this family (28)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7485440B2 (en) | 1995-09-27 | 2009-02-03 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US20030082209A1 (en) | 2000-07-05 | 2003-05-01 | Skiadopoulos Mario H. | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7951383B2 (en) | 1997-05-23 | 2011-05-31 | The United States Of America As Represented By The Department Of Health And Human Services | Attenuated parainfluenza virus (PIV) vaccines |
US7632508B2 (en) | 1997-05-23 | 2009-12-15 | The United States Of America | Attenuated human-bovine chimeric parainfluenza virus (PIV) vaccines |
US7201907B1 (en) | 1997-05-23 | 2007-04-10 | The United States Of America, Represented By The Secretary, Department Of Health And Human Services | Attenuated human-bovine chimeric parainfluenza virus(PIV) vaccines |
US7662397B2 (en) | 1997-07-15 | 2010-02-16 | The United States Of America As Represented By The Department Of Health And Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
US20040005542A1 (en) | 2001-06-22 | 2004-01-08 | Krempl Christine D | Respiratory syncytial virus vaccines expressing protective antigens from promotor- proximal genes |
MXPA02000490A (es) * | 1999-07-13 | 2004-09-27 | Us Gov Health & Human Serv | Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras. |
AU2003270824B2 (en) | 2002-09-18 | 2009-02-19 | The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services | Recovery of recombinant human parainfluenza virus type 2 (HPIV2) from cDNA and use of recombinant HPIV2 in immunogenic compositions and as vectors to elicit immune responses against PIV and other human pathogens |
CA2517394A1 (en) | 2003-02-28 | 2005-02-17 | The Government Of The United States Of America As Represented By The Sec Retary Of The Department Of Health And Human Services | Recombinant human metapneumovirus and its use |
EP1633860A2 (de) | 2003-06-09 | 2006-03-15 | Wyeth | VERBESSERTES VERFAHREN ZUR GEWINNUNG NICHTSEGMENTIERTER NEGATIV-STRANG-RNA-VIREN AUS cDNA |
US7588770B2 (en) | 2003-12-10 | 2009-09-15 | The Uab Research Foundation | Recombinant viruses of the paramyxoviridae family with heterologous envelope glycoproteins |
WO2007060725A1 (ja) * | 2005-11-24 | 2007-05-31 | The Research Foundation For Microbial Diseases Of Osaka University | 組換え多価ワクチン |
US20100260792A1 (en) * | 2007-10-22 | 2010-10-14 | University Of Rochester | Respiratory syncytial virus vaccine based on chimeric papillomavirus virus-like particles or capsomeres |
WO2010003032A2 (en) * | 2008-07-01 | 2010-01-07 | The Government Of The United States Of America, Represented By The Secretary, Department Of Health A | Recombinant human parainfluenza type 1 viruses (hpiv1s) containing mutations in or deletion of the c protein are attenuated in african green monkeys and in ciliated human airway epithelial cells and are potential vaccine candidates for hpiv1 |
BRPI0921424A2 (pt) | 2008-11-05 | 2016-01-05 | Merck Sharp & Dohme | vírus sincicial respiratório atenuado, composição imunogênica, molécula de ácido nucléico, célula recombinante, método para produzir uma resposta imune protetiva em um paciente, e, uso de uma quantidade imunologicamente eficaz de um ou mais dos seguintes: um rsv atenuado, uma população de rsv atenuado e uma composição imunogênica. |
GB201019240D0 (en) * | 2010-11-15 | 2010-12-29 | Vib Vzw | Respiratory syncytical virus vaccine |
WO2012085936A2 (en) * | 2010-12-20 | 2012-06-28 | Panacea Biotech Ltd | Recombinant respiratory syncytial virus plasmids and vaccines |
CN102210859B (zh) * | 2011-05-31 | 2012-11-21 | 昆明理工大学 | 一种结核分枝杆菌esat-6-f2融合蛋白亚单位疫苗及其制备方法 |
EP3875112A1 (de) * | 2012-04-13 | 2021-09-08 | The United States of America, as Represented By the Secretary, Department of Health and Human Services | Genetisch stabiler, lebend abgeschwächter impfstoff gegen das respiratorische synzytialvirus und dessen herstellung |
JP2014236748A (ja) * | 2014-08-26 | 2014-12-18 | 一般財団法人阪大微生物病研究会 | 組換え多価ワクチン |
JP7020917B2 (ja) | 2015-01-20 | 2022-02-16 | ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ | キメラrsv/bpiv3 fタンパクを発現する組換えヒト/ウシパラインフルエンザウイルス3(b/hpiv3)およびその使用 |
MX2019011599A (es) * | 2017-03-30 | 2019-12-19 | Univ Queensland | Moleculas quimericas y usos de las mismas. |
JP7371009B2 (ja) * | 2018-04-23 | 2023-10-30 | アメリカ合衆国 | キメラベクター |
KR102567994B1 (ko) * | 2018-10-12 | 2023-08-17 | 에스케이바이오사이언스(주) | 재조합 rsv 생백신주 및 이의 제조 방법 |
CN110229219B (zh) * | 2019-06-21 | 2021-03-30 | 中国科学院武汉病毒研究所 | 一种新型的呼吸道合胞病毒疫苗抗原的制备方法及其用途 |
WO2023183700A2 (en) * | 2022-03-22 | 2023-09-28 | Mayo Foundation For Medical Education And Research | Morreton viruses and methods of use |
CN116676275B (zh) * | 2023-03-17 | 2024-06-07 | 北京赛尔富森生物科技有限公司 | A基因型嵌合腮腺炎病毒株和制备方法及用途 |
Family Cites Families (29)
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US4683202A (en) | 1985-03-28 | 1987-07-28 | Cetus Corporation | Process for amplifying nucleic acid sequences |
US4683195A (en) | 1986-01-30 | 1987-07-28 | Cetus Corporation | Process for amplifying, detecting, and/or-cloning nucleic acid sequences |
US4800078A (en) | 1987-05-28 | 1989-01-24 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Immunotherapeutic method of treating respiratory disease by intranasal administration of Igb |
AU7007491A (en) | 1990-02-02 | 1991-08-08 | Schweiz. Serum- & Impfinstitut Bern | Cdna corresponding to the genome of negative-strand rna viruses, and process for the production of infectious negative-strand rna viruses |
GB9200117D0 (en) | 1992-01-06 | 1992-02-26 | Connaught Lab | Production of recombinant chimeric proteins for vaccine use |
IL105456A (en) | 1992-04-21 | 1996-12-05 | American Home Prod | Vaccines of attenuated respiratory syncytial virus |
AU3660893A (en) | 1993-01-29 | 1994-08-15 | Med Immune, Inc. | Human-murine chimeric antibodies against respiratory syncytial virus |
ATE257175T1 (de) | 1994-07-18 | 2004-01-15 | Conzelmann Karl Klaus Prof Dr | Rekombinantes infektiöses nicht-in-segmente- geteiltes, negativ-strange-rns-virus |
US20030054505A1 (en) * | 1997-09-26 | 2003-03-20 | Hong Jin | Recombinant rsv expression systems and vaccines |
WO1996010400A1 (en) | 1994-09-30 | 1996-04-11 | The Uab Research Foundation | Gene therapy vectors and vaccines based on non-segmented negatives stranded rna viruses |
US5716821A (en) | 1994-09-30 | 1998-02-10 | Uab Research Foundation | Prevention and treatment of respiratory tract disease |
DE69510207T3 (de) | 1995-08-09 | 2007-02-15 | Schweiz. Serum- & Impfinstitut Bern | Verfahren zur Herstellung von infektiösen minussträngigen RNA-Viren |
US6165774A (en) | 1995-09-22 | 2000-12-26 | Connaught Laboratories Limited | Parainfluenza virus glycoproteins and vaccines |
US6689367B1 (en) | 1995-09-27 | 2004-02-10 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
US6923971B2 (en) | 1995-09-27 | 2005-08-02 | The United States Of America As Represented By The Department Of Health & Human Services | Respiratory syncytial virus vaccines expressing protective antigens from promoter-proximal genes |
JPH11512609A (ja) | 1995-09-27 | 1999-11-02 | アメリカ合衆国 | クローン化されたヌクレオチド配列からの感染性RSウイルス(respiratory syncytial virus)の生産 |
US6713066B1 (en) | 1996-07-15 | 2004-03-30 | The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
US5869036A (en) | 1995-12-08 | 1999-02-09 | St. Louis University | Live attenuated vaccines based on CP45 HPIV-3 strain and method to ensure attenuation in such vaccine |
US6077514A (en) | 1996-04-04 | 2000-06-20 | The Regents Of The University Of Michigan | Attenuated respiratory syncytial virus |
EP2112220A3 (de) | 1996-07-15 | 2010-01-06 | The Government of the United States of America, as represented by The Department of Health and Human Services | Herstellung abgeschwächter Impfstoffe gegen das respiratorische Synzytialvirus aus geklonten Nukleotidsequenzen |
US6699476B1 (en) | 1996-07-15 | 2004-03-02 | Peter L. Collins | Production of recombinant respiratory syncytial viruses expressing immune modulatory molecules |
AU7797798A (en) | 1997-05-23 | 1998-12-11 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of attenuated parainfluenza virus vaccines from cloned nucleotide sequences |
PT1012244E (pt) | 1997-07-11 | 2007-08-21 | Univ Yale | ''rabdovírus com revestimentos remanipulados'' |
AU1297299A (en) * | 1997-11-10 | 1999-05-31 | University Of Maryland | Production of novel bovine respiratory syncytial viruses from cdnas |
MXPA01010392A (es) | 1999-04-13 | 2003-09-15 | Us Gov Health & Human Serv | Produccion de vacunas de virus con arn de hebra negativa atenuados a partir de secuencias de nucleotidos clonadas. |
WO2000061611A2 (en) | 1999-04-13 | 2000-10-19 | The Government Of The United States Of America As Represented By The Department Of Health And Human Services | Production of attenuated chimeric respiratory syncytial virus vaccines from cloned nucleotide sequences |
AU5918100A (en) | 1999-07-09 | 2001-01-30 | Government Of The United States Of America, As Represented By The Secretary Of The Department Of Health And Human Services, The | Production of attenuated respiratory syncytial virus vaccines involving modification of M2 ORF2 |
MXPA02000490A (es) | 1999-07-13 | 2004-09-27 | Us Gov Health & Human Serv | Produccion de virus sincitiales respiratorios recombinantes, que expresan moleculas inmunomoduladoras. |
KR100899030B1 (ko) * | 2000-06-23 | 2009-05-21 | 더 가버먼트 오브 더 유나이티드 스테이츠 오브 어메리카 애즈 리프리젠티드 바이 더 디파트먼트 오브 헬스 앤 휴먼 서비씨즈 | 프로모터 인접 유전자로부터 보호적 항원을 발현하는호흡기 신시티움 바이러스 백신 |
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2000
- 2000-06-23 EP EP00941756A patent/EP1287152B1/de not_active Expired - Lifetime
- 2000-06-23 MX MXPA02000220A patent/MXPA02000220A/es not_active Application Discontinuation
- 2000-06-23 WO PCT/US2000/017755 patent/WO2001004335A2/en active Application Filing
- 2000-06-23 BR BR0013195-4A patent/BR0013195A/pt not_active IP Right Cessation
- 2000-06-23 KR KR1020027000318A patent/KR100905450B1/ko not_active IP Right Cessation
- 2000-06-23 AT AT00941756T patent/ATE419369T1/de not_active IP Right Cessation
- 2000-06-23 CN CNB008101191A patent/CN100354425C/zh not_active Expired - Fee Related
- 2000-06-23 JP JP2001509539A patent/JP2003530073A/ja not_active Ceased
- 2000-06-23 CA CA002378552A patent/CA2378552A1/en not_active Abandoned
- 2000-06-23 DE DE60041280T patent/DE60041280D1/de not_active Expired - Lifetime
- 2000-06-23 CN CNA2007101671126A patent/CN101260386A/zh active Pending
- 2000-06-24 IL IL14744700A patent/IL147447A0/xx unknown
- 2000-06-24 AU AU56415/00A patent/AU784216B2/en not_active Ceased
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2002
- 2002-01-03 IL IL147447A patent/IL147447A/en not_active IP Right Cessation
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2005
- 2005-03-31 US US11/097,946 patent/US7829102B2/en not_active Expired - Fee Related
- 2005-08-11 US US11/203,620 patent/US7842798B2/en not_active Expired - Fee Related
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2006
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Also Published As
Publication number | Publication date |
---|---|
US20070184069A1 (en) | 2007-08-09 |
EP1287152A2 (de) | 2003-03-05 |
WO2001004335A2 (en) | 2001-01-18 |
IL147447A (en) | 2010-05-31 |
KR20020092343A (ko) | 2002-12-11 |
AU5641500A (en) | 2001-01-30 |
AU784216B2 (en) | 2006-02-23 |
JP2003530073A (ja) | 2003-10-14 |
US7842798B2 (en) | 2010-11-30 |
AU2006202170A1 (en) | 2006-06-15 |
EP1287152B1 (de) | 2008-12-31 |
MXPA02000220A (es) | 2005-08-16 |
CN101260386A (zh) | 2008-09-10 |
WO2001004335A3 (en) | 2002-12-19 |
BR0013195A (pt) | 2002-07-23 |
CA2378552A1 (en) | 2001-01-18 |
WO2001004335A8 (en) | 2003-02-06 |
AU2006202170B2 (en) | 2009-10-08 |
KR100905450B1 (ko) | 2009-07-02 |
US20060057158A1 (en) | 2006-03-16 |
DE60041280D1 (de) | 2009-02-12 |
US7829102B2 (en) | 2010-11-09 |
CN1402792A (zh) | 2003-03-12 |
CN100354425C (zh) | 2007-12-12 |
IL147447A0 (en) | 2002-08-14 |
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