DE60335350D1 - Adjuvantien für dns impstoffe basierend auf imidazochinoline - Google Patents

Adjuvantien für dns impstoffe basierend auf imidazochinoline

Info

Publication number
DE60335350D1
DE60335350D1 DE60335350T DE60335350T DE60335350D1 DE 60335350 D1 DE60335350 D1 DE 60335350D1 DE 60335350 T DE60335350 T DE 60335350T DE 60335350 T DE60335350 T DE 60335350T DE 60335350 D1 DE60335350 D1 DE 60335350D1
Authority
DE
Germany
Prior art keywords
imidazochinoline
adjuvanties
dna vaccines
vaccines based
relates
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired - Lifetime
Application number
DE60335350T
Other languages
English (en)
Inventor
Ralph Patrick Braun
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Powderject Research Ltd
Original Assignee
Powderject Research Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/102,615 external-priority patent/US20030185835A1/en
Application filed by Powderject Research Ltd filed Critical Powderject Research Ltd
Application granted granted Critical
Publication of DE60335350D1 publication Critical patent/DE60335350D1/de
Anticipated expiration legal-status Critical
Expired - Lifetime legal-status Critical Current

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DE60335350T 2002-03-19 2003-03-19 Adjuvantien für dns impstoffe basierend auf imidazochinoline Expired - Lifetime DE60335350D1 (de)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36605702P 2002-03-19 2002-03-19
US10/102,615 US20030185835A1 (en) 2002-03-19 2002-03-19 Adjuvant for vaccines
PCT/GB2003/001203 WO2003080114A2 (en) 2002-03-19 2003-03-19 Imidazoquinoline adjuvants for vaccines

Publications (1)

Publication Number Publication Date
DE60335350D1 true DE60335350D1 (de) 2011-01-27

Family

ID=28456582

Family Applications (1)

Application Number Title Priority Date Filing Date
DE60335350T Expired - Lifetime DE60335350D1 (de) 2002-03-19 2003-03-19 Adjuvantien für dns impstoffe basierend auf imidazochinoline

Country Status (10)

Country Link
US (1) US20060088542A1 (de)
EP (1) EP1487485B1 (de)
JP (1) JP2005526793A (de)
AT (1) ATE491471T1 (de)
AU (1) AU2003216851B2 (de)
CA (1) CA2484049A1 (de)
DE (1) DE60335350D1 (de)
DK (1) DK1487485T3 (de)
PT (1) PT1487485E (de)
WO (1) WO2003080114A2 (de)

Families Citing this family (46)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2003301052A1 (en) 2002-12-20 2004-07-22 3M Innovative Properties Company Aryl / hetaryl substituted imidazoquinolines
US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
EP1660122A4 (de) * 2003-08-25 2007-10-24 3M Innovative Properties Co Immunstimulatorische kombinationen und behandlungen
EP1658076B1 (de) * 2003-08-27 2013-03-06 3M Innovative Properties Company Aryloxy- und arylalkylenoxy-substituierte imidazochinoline
CA2540598C (en) 2003-10-03 2013-09-24 3M Innovative Properties Company Pyrazolopyridines and analogs thereof
AU2004278014B2 (en) 2003-10-03 2011-04-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
KR20060123138A (ko) * 2003-10-10 2006-12-01 파우더젝트 백신, 인코포레이티드 방법
AR046781A1 (es) 2003-11-25 2005-12-21 3M Innovative Properties Co Derivados de imidazoquinolinas. composiciones farmaceuticas.
US8541438B2 (en) 2004-06-18 2013-09-24 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
WO2006009826A1 (en) * 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
DE102004049223A1 (de) 2004-10-08 2006-04-20 Johannes-Gutenberg-Universität Mainz Zubereitung zum Impfen, Impfverfahren und Verwendung einer Impf-Zubereitung
AU2005322898B2 (en) 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
EP1831221B1 (de) 2004-12-30 2012-08-08 3M Innovative Properties Company Substituierte, chirale, fusionierte 1,2 imidazo-4,5-c-ringverbindungen
JP2008530022A (ja) 2005-02-04 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド 免疫反応調節物質を含む水性ゲル処方物
CA2597324C (en) 2005-02-09 2015-06-30 Coley Pharmaceutical Group, Inc. Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1877056A2 (de) 2005-02-09 2008-01-16 Coley Pharmaceutical Group, Inc. Oxim- und hydroxylaminsubstituierte thiazol-4,5-c-ringverbindungen und verfahren dafür
CA2597446A1 (en) * 2005-02-11 2006-08-31 Coley Pharmaceutical Group, Inc. Substituted imidazoquinolines and imidazonaphthyridines
EP1851220A2 (de) 2005-02-23 2007-11-07 3M Innovative Properties Company Hydroxyalkylsubstituierte imidazonaphthyridine
WO2006091567A2 (en) * 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Hydroxyalkyl substituted imidazoquinoline compounds and methods
US8178677B2 (en) * 2005-02-23 2012-05-15 3M Innovative Properties Company Hydroxyalkyl substituted imidazoquinolines
WO2006091647A2 (en) * 2005-02-23 2006-08-31 Coley Pharmaceutical Group, Inc. Method of preferentially inducing the biosynthesis of interferon
JP2009507856A (ja) * 2005-09-09 2009-02-26 コーリー ファーマシューティカル グループ，インコーポレイテッド Ｎ−｛２−［４−アミノ−２−（エトキシメチル）−１Ｈ−イミダゾ［４，５−ｃ］キノリン−１−イル］−１，１−ジメチルエチル｝メタンスルホンアミドのアミドおよびカルバマート誘導体ならびに方法
ZA200803029B (en) 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
CA2628424A1 (en) * 2005-11-04 2007-05-10 Novartis Vaccines And Diagnostics S.R.L. Adjuvanted influenza vaccines including cytokine-inducing agents
AU2006311871B2 (en) 2005-11-04 2011-03-03 3M Innovative Properties Company Hydroxy and alkoxy substituted 1H-imidazoquinolines and methods
US8951528B2 (en) 2006-02-22 2015-02-10 3M Innovative Properties Company Immune response modifier conjugates
WO2007106854A2 (en) * 2006-03-15 2007-09-20 Coley Pharmaceutical Group, Inc. Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods
CN101472610A (zh) 2006-06-20 2009-07-01 特朗斯吉有限公司 重组病毒疫苗
US20100092401A1 (en) * 2006-07-18 2010-04-15 Graceway Pharmaceuticals, Llc Immune response modifier formulations
WO2008030511A2 (en) * 2006-09-06 2008-03-13 Coley Pharmaceuticial Group, Inc. Substituted 3,4,6,7-tetrahydro-5h, 1,2a,4a,8-tetraazacyclopenta[cd]phenalenes
US8815253B2 (en) 2007-12-07 2014-08-26 Novartis Ag Compositions for inducing immune responses
JP5311508B2 (ja) * 2008-05-07 2013-10-09 国立大学法人大阪大学 非共有結合型コラーゲン架橋剤
JP2012515722A (ja) * 2009-01-20 2012-07-12 ノースウェスタン ユニバーシティ 抗原特異的寛容の誘導のための組成物および方法
CN105294684B (zh) 2010-08-17 2018-04-06 3M创新有限公司 脂质化免疫反应调节剂化合物的组合物、制剂及方法
US20130323319A1 (en) 2010-11-12 2013-12-05 Getts Consulting And Project Management Modified immune-modulating particles
CA2838158C (en) 2011-06-03 2019-07-16 3M Innovative Properties Company Heterobifunctional linkers with polyethylene glycol segments and immune response modifier conjugates made therefrom
EP3153180A1 (de) 2011-06-03 2017-04-12 3M Innovative Properties Company Heterobifunktionale binder mit polyethylenglykolsegmenten und daraus hergestellte immunantwort-modifizierende konjugate
ES2738481T3 (es) 2012-06-21 2020-01-23 Univ Northwestern Partículas peptídicas conjugadas
IL292823B2 (en) 2013-03-13 2023-11-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
KR20230008909A (ko) 2013-08-13 2023-01-16 노쓰웨스턴유니버시티 펩티드-접합된 입자
US9884866B2 (en) 2014-09-08 2018-02-06 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
US10730871B2 (en) 2016-01-28 2020-08-04 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
EP3728255B1 (de) 2017-12-20 2022-01-26 3M Innovative Properties Company Amid-substituierte imidazo[4,5-c]chinolin-verbindungen mit verzweigtkettenverbindungsgruppe zur verwendung als immunreaktionsmodifikator

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US5238944A (en) * 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
KR100341341B1 (ko) * 1993-07-15 2002-11-25 미네소타 마이닝 앤드 매뉴팩춰링 캄파니 이미다조[4,5-c]피리딘-4-아민
US5352784A (en) * 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
US5482936A (en) * 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US20010006950A1 (en) * 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6110929A (en) * 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
DE69803856D1 (de) * 1998-11-27 2002-03-21 St Microelectronics Srl Flash Analog-Digitalwandler
BR0007435A (pt) * 1999-01-08 2001-12-04 3M Innovative Properties Co Formulações e métodos para tratamento decondições associadas com mucosa com ummodificador de resposta imunológica
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
GB0023008D0 (en) * 2000-09-20 2000-11-01 Glaxo Group Ltd Improvements in vaccination
EP1487486B1 (de) * 2002-03-19 2009-01-14 PowderJect Research Limited Imidazoquinolinamine als adjuvantien für hiv dna vakzine
US20030190308A1 (en) * 2002-03-19 2003-10-09 Braun Ralph P. Adjuvant
GB0206461D0 (en) * 2002-03-19 2002-05-01 Glaxo Group Ltd Improvements in vaccination

Also Published As

Publication number Publication date
WO2003080114A2 (en) 2003-10-02
US20060088542A1 (en) 2006-04-27
DK1487485T3 (da) 2011-03-14
EP1487485A2 (de) 2004-12-22
ATE491471T1 (de) 2011-01-15
AU2003216851A1 (en) 2003-10-08
EP1487485B1 (de) 2010-12-15
CA2484049A1 (en) 2003-10-02
WO2003080114A3 (en) 2003-11-06
JP2005526793A (ja) 2005-09-08
PT1487485E (pt) 2011-03-11
AU2003216851B2 (en) 2008-04-17

Similar Documents

Publication Publication Date Title
ATE491471T1 (de) Adjuvantien für dns impstoffe basierend auf imidazochinoline
BR0313414A (pt) ácidos nucléicos imunoestimulatórios
ATE426412T1 (de) Adjuvante influenza-vakzine
NO20070263L (no) Immunostimulerende oligonukleotidmultimerer
CY1112490T1 (el) Σταθεροποιητες για εμβολια ξηρανθεντα δια καταψυξεως
BRPI0508064A (pt) flavivìrus, composição de vacina e molécula de ácido nucléico
DE60228758D1 (de) Immunisierung gegen chlamydia tracheomatis
WO2007075626A3 (en) Immunostimulatory activity of palindromic immune modulatory oligonucleotides (imo tm) contiaining different lengths of palindromic segments
CY1107390T1 (el) Εμβολιο εναντι αντιγονων απο βακτηριδια
NZ593220A (en) Immunostimulatory oligonucleotides
MXPA05009580A (es) Vacuna contra el virus de la influenza.
ATE463575T1 (de) Chlamydia antigene, entsprechende dns fragmente und ihre verwendungen
ATE521621T1 (de) Cpg-einzelstrang-desoxynukleotide zur verwendung als adjuvans
DE60037900D1 (de) Chlamydia antigene und entsprechende dna-fragmente und ihre verwendungen
ATE392216T1 (de) Mycobakterieller impfstoff
DK1379273T3 (da) Nukleinsyreadjuvanser
DE602004024423D1 (de) Impfstoff mit lawsonia intracellularis-untereinheit
ATE420658T1 (de) Imidazoquinolinamine als adjuvantien für hiv dna vakzine
CY1107845T1 (el) Γενετικα εμβολια με ανοσοενισχυτικο
EP1667634A4 (de) Anthrax-vakzine
ATE414905T1 (de) Diabetesmodell
BRPI0604365A (pt) polipeptìdeo isolado, composição de vacina anti-carrapato de múltiplas espécies, e, uso dos mesmos
WO2003031470A3 (de) Dna-expressionskonstrukt zur behandlung von infektionen mit leishmaniose
CY1112454T1 (el) Ανασυνδυασμενη καρβοξυπεπτιδαση β
SE0100412D0 (sv) Novel human poly(A) polymerase