DK1487485T3 - Imidazoquinolinadjuvanser til DNA-vacciner - Google Patents

Imidazoquinolinadjuvanser til DNA-vacciner

Info

Publication number
DK1487485T3
DK1487485T3 DK03712390.8T DK03712390T DK1487485T3 DK 1487485 T3 DK1487485 T3 DK 1487485T3 DK 03712390 T DK03712390 T DK 03712390T DK 1487485 T3 DK1487485 T3 DK 1487485T3
Authority
DK
Denmark
Prior art keywords
adjuvants
dna vaccines
relates
nucleic acid
imidazoquinoline
Prior art date
Application number
DK03712390.8T
Other languages
English (en)
Inventor
Ralph Patrick Braun
Original Assignee
Powderject Res Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US10/102,615 external-priority patent/US20030185835A1/en
Application filed by Powderject Res Ltd filed Critical Powderject Res Ltd
Application granted granted Critical
Publication of DK1487485T3 publication Critical patent/DK1487485T3/da

Links

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/39—Medicinal preparations containing antigens or antibodies characterised by the immunostimulating additives, e.g. chemical adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Mycology (AREA)
  • Microbiology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
DK03712390.8T 2002-03-19 2003-03-19 Imidazoquinolinadjuvanser til DNA-vacciner DK1487485T3 (da)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US36605702P 2002-03-19 2002-03-19
US10/102,615 US20030185835A1 (en) 2002-03-19 2002-03-19 Adjuvant for vaccines
PCT/GB2003/001203 WO2003080114A2 (en) 2002-03-19 2003-03-19 Imidazoquinoline adjuvants for vaccines

Publications (1)

Publication Number Publication Date
DK1487485T3 true DK1487485T3 (da) 2011-03-14

Family

ID=28456582

Family Applications (1)

Application Number Title Priority Date Filing Date
DK03712390.8T DK1487485T3 (da) 2002-03-19 2003-03-19 Imidazoquinolinadjuvanser til DNA-vacciner

Country Status (10)

Country Link
US (1) US20060088542A1 (da)
EP (1) EP1487485B1 (da)
JP (1) JP2005526793A (da)
AT (1) ATE491471T1 (da)
AU (1) AU2003216851B2 (da)
CA (1) CA2484049A1 (da)
DE (1) DE60335350D1 (da)
DK (1) DK1487485T3 (da)
PT (1) PT1487485E (da)
WO (1) WO2003080114A2 (da)

Families Citing this family (47)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2004058759A1 (en) 2002-12-20 2004-07-15 3M Innovative Properties Company Aryl / hetaryl substituted imidazoquinolines
US20040265351A1 (en) 2003-04-10 2004-12-30 Miller Richard L. Methods and compositions for enhancing immune response
US7731967B2 (en) 2003-04-30 2010-06-08 Novartis Vaccines And Diagnostics, Inc. Compositions for inducing immune responses
US7176214B2 (en) 2003-05-21 2007-02-13 Bristol-Myers Squibb Company Imidazo-fused oxazolo[4,5-β]pyridine and imidazo-fused thiazolo[4,5-β]pyridine based tricyclic compounds and pharmaceutical compositions comprising same
US20050048072A1 (en) * 2003-08-25 2005-03-03 3M Innovative Properties Company Immunostimulatory combinations and treatments
US7897597B2 (en) * 2003-08-27 2011-03-01 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted imidazoquinolines
US8871782B2 (en) 2003-10-03 2014-10-28 3M Innovative Properties Company Alkoxy substituted imidazoquinolines
CA2540598C (en) 2003-10-03 2013-09-24 3M Innovative Properties Company Pyrazolopyridines and analogs thereof
SG146662A1 (en) * 2003-10-10 2008-10-30 Powderject Vaccines Inc Method
AU2004293078B2 (en) 2003-11-25 2012-01-19 3M Innovative Properties Company Substituted imidazo ring systems and methods
US8541438B2 (en) 2004-06-18 2013-09-24 3M Innovative Properties Company Substituted imidazoquinolines, imidazopyridines, and imidazonaphthyridines
WO2006009826A1 (en) * 2004-06-18 2006-01-26 3M Innovative Properties Company Aryloxy and arylalkyleneoxy substituted thiazoloquinolines and thiazolonaphthyridines
DE102004049223A1 (de) 2004-10-08 2006-04-20 Johannes-Gutenberg-Universität Mainz Zubereitung zum Impfen, Impfverfahren und Verwendung einer Impf-Zubereitung
AU2005322898B2 (en) * 2004-12-30 2011-11-24 3M Innovative Properties Company Chiral fused (1,2)imidazo(4,5-c) ring compounds
JP5313502B2 (ja) 2004-12-30 2013-10-09 スリーエム イノベイティブ プロパティズ カンパニー 置換キラル縮合［１，２］イミダゾ［４，５−ｃ］環状化合物
AU2006210392A1 (en) 2005-02-04 2006-08-10 Coley Pharmaceutical Group, Inc. Aqueous gel formulations containing immune response modifiers
JP2008530252A (ja) 2005-02-09 2008-08-07 コーリー ファーマシューティカル グループ，インコーポレイテッド オキシムおよびヒドロキシルアミンで置換されたチアゾロ［４，５−ｃ］環化合物ならびに方法
CA2597324C (en) 2005-02-09 2015-06-30 Coley Pharmaceutical Group, Inc. Alkyloxy substituted thiazoloquinolines and thiazolonaphthyridines
EP1845988A2 (en) * 2005-02-11 2007-10-24 3M Innovative Properties Company Substituted imidazoquinolines and imidazonaphthyridines
JP2008531567A (ja) * 2005-02-23 2008-08-14 コーリー ファーマシューティカル グループ，インコーポレイテッド ヒドロキシアルキル置換イミダゾキノリン化合物および方法
EP1851220A2 (en) 2005-02-23 2007-11-07 3M Innovative Properties Company Hydroxyalkyl substituted imidazonaphthyridines
JP2008538203A (ja) * 2005-02-23 2008-10-16 コーリー ファーマシューティカル グループ，インコーポレイテッド インターフェロンの生合成を優先的に誘導する方法
AU2006223634A1 (en) * 2005-02-23 2006-09-21 Coley Pharmaceutical Group, Inc. Hydroxyalkyl substituted imidazoquinolines
US8476292B2 (en) * 2005-09-09 2013-07-02 3M Innovative Properties Company Amide and carbamate derivatives of N-{2-[4-amino-2-(ethoxymethyl)-1H-imidazo[4,5-c] quinolin-1-Yl]-1,1-dimethylethyl}methanesulfonamide and methods
ZA200803029B (en) 2005-09-09 2009-02-25 Coley Pharm Group Inc Amide and carbamate derivatives of alkyl substituted /V-[4-(4-amino-1H-imidazo[4,5-c] quinolin-1-yl)butyl] methane-sulfonamides and methods
NZ592713A (en) * 2005-11-04 2012-12-21 Novartis Vaccines & Diagnostic Adjuvanted influenza vaccines including a cytokine-inducing agents other than an agonist of Toll-Like Receptor 9
EP1948173B1 (en) * 2005-11-04 2013-07-17 3M Innovative Properties Company Hydroxy and alkoxy substituted 1h-imidazoquinolines and methods
US8951528B2 (en) 2006-02-22 2015-02-10 3M Innovative Properties Company Immune response modifier conjugates
WO2007106854A2 (en) * 2006-03-15 2007-09-20 Coley Pharmaceutical Group, Inc. Hydroxy and alkoxy substituted 1h-imidazonaphthyridines and methods
US20100129403A1 (en) * 2006-06-20 2010-05-27 Transgene S.A. Recombinant viral vaccine
EP1889609B1 (en) * 2006-07-18 2019-05-22 Meda AB Immune response modifier foam formulations
WO2008030511A2 (en) * 2006-09-06 2008-03-13 Coley Pharmaceuticial Group, Inc. Substituted 3,4,6,7-tetrahydro-5h, 1,2a,4a,8-tetraazacyclopenta[cd]phenalenes
EP3067048B1 (en) 2007-12-07 2018-02-14 GlaxoSmithKline Biologicals SA Compositions for inducing immune responses
JP5311508B2 (ja) * 2008-05-07 2013-10-09 国立大学法人大阪大学 非共有結合型コラーゲン架橋剤
SG193843A1 (en) * 2009-01-20 2013-10-30 Univ Northwestern Compositions and methods for induction of antigen-specific tolerance
EP3222621B1 (en) 2010-08-17 2023-03-08 3M Innovative Properties Company Lipidated immune response modifier compound and its medical use
AU2011325966B2 (en) 2010-11-12 2016-09-29 Oncour Pharma, Inc. Modified immune-modulating particles
JP6415979B2 (ja) 2011-06-03 2018-10-31 スリーエム イノベイティブ プロパティズ カンパニー ヒドラジノ１ｈ−イミダゾキノリン−４−アミン及びこれから調製された複合体
MX347240B (es) 2011-06-03 2017-04-20 3M Innovative Properties Co Ligadores heterobifuncionales con segmentos polietilenglicol y conjugados modificadores de la respuesta inmunitaria elaborados a partir de los mismos.
CN110064049B (zh) 2012-06-21 2024-02-09 西北大学 肽缀合粒子
IL292823B2 (en) 2013-03-13 2023-11-01 Cour Pharmaceuticals Dev Company Secondary vaccine particles for the treatment of inflammation
MX2016001931A (es) 2013-08-13 2016-09-07 Univ Northwestern Particulas conjugadas con peptidos.
US9884866B2 (en) 2014-09-08 2018-02-06 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
MA44334A (fr) 2015-10-29 2018-09-05 Novartis Ag Conjugués d'anticorps comprenant un agoniste du récepteur de type toll
US10730871B2 (en) 2016-01-28 2020-08-04 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
CN111511740B (zh) 2017-12-20 2023-05-16 3M创新有限公司 用作免疫应答调节剂的带有支链连接基团的酰胺取代的咪唑并[4,5-c]喹啉化合物
WO2020009946A1 (en) 2018-07-02 2020-01-09 Regents Of The University Of Minnesota Therapeutic compounds and methods of use thereof

Family Cites Families (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL73534A (en) * 1983-11-18 1990-12-23 Riker Laboratories Inc 1h-imidazo(4,5-c)quinoline-4-amines,their preparation and pharmaceutical compositions containing certain such compounds
US5238944A (en) * 1988-12-15 1993-08-24 Riker Laboratories, Inc. Topical formulations and transdermal delivery systems containing 1-isobutyl-1H-imidazo[4,5-c]quinolin-4-amine
US4929624A (en) * 1989-03-23 1990-05-29 Minnesota Mining And Manufacturing Company Olefinic 1H-imidazo(4,5-c)quinolin-4-amines
US5389640A (en) * 1991-03-01 1995-02-14 Minnesota Mining And Manufacturing Company 1-substituted, 2-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5268376A (en) * 1991-09-04 1993-12-07 Minnesota Mining And Manufacturing Company 1-substituted 1H-imidazo[4,5-c]quinolin-4-amines
US5266575A (en) * 1991-11-06 1993-11-30 Minnesota Mining And Manufacturing Company 2-ethyl 1H-imidazo[4,5-ciquinolin-4-amines
IL105325A (en) * 1992-04-16 1996-11-14 Minnesota Mining & Mfg Immunogen/vaccine adjuvant composition
US5395937A (en) * 1993-01-29 1995-03-07 Minnesota Mining And Manufacturing Company Process for preparing quinoline amines
US5352784A (en) * 1993-07-15 1994-10-04 Minnesota Mining And Manufacturing Company Fused cycloalkylimidazopyridines
EP0708772B1 (en) * 1993-07-15 2000-08-23 Minnesota Mining And Manufacturing Company IMIDAZO [4,5-c]PYRIDIN-4-AMINES
US5482936A (en) * 1995-01-12 1996-01-09 Minnesota Mining And Manufacturing Company Imidazo[4,5-C]quinoline amines
US20010006950A1 (en) * 1998-02-11 2001-07-05 Juha Punnonen Genetic vaccine vector engineering
US6110929A (en) * 1998-07-28 2000-08-29 3M Innovative Properties Company Oxazolo, thiazolo and selenazolo [4,5-c]-quinolin-4-amines and analogs thereof
DE69803856D1 (de) * 1998-11-27 2002-03-21 St Microelectronics Srl Flash Analog-Digitalwandler
NZ512628A (en) * 1999-01-08 2004-03-26 3M Innovative Properties Co Formulations and methods for treatment of mucosal associated conditions with an immune response modifier
US6558951B1 (en) * 1999-02-11 2003-05-06 3M Innovative Properties Company Maturation of dendritic cells with immune response modifying compounds
US6331539B1 (en) * 1999-06-10 2001-12-18 3M Innovative Properties Company Sulfonamide and sulfamide substituted imidazoquinolines
GB0023008D0 (en) * 2000-09-20 2000-11-01 Glaxo Group Ltd Improvements in vaccination
GB0206461D0 (en) * 2002-03-19 2002-05-01 Glaxo Group Ltd Improvements in vaccination
US20030190308A1 (en) * 2002-03-19 2003-10-09 Braun Ralph P. Adjuvant
WO2003080112A2 (en) * 2002-03-19 2003-10-02 Powdermed Limited Imidazoquinolineamines as adjuvants in hiv dna vaccination

Also Published As

Publication number Publication date
AU2003216851A1 (en) 2003-10-08
AU2003216851B2 (en) 2008-04-17
US20060088542A1 (en) 2006-04-27
ATE491471T1 (de) 2011-01-15
DE60335350D1 (de) 2011-01-27
WO2003080114A2 (en) 2003-10-02
PT1487485E (pt) 2011-03-11
JP2005526793A (ja) 2005-09-08
EP1487485B1 (en) 2010-12-15
WO2003080114A3 (en) 2003-11-06
CA2484049A1 (en) 2003-10-02
EP1487485A2 (en) 2004-12-22

Similar Documents

Publication Publication Date Title
DK1487485T3 (da) Imidazoquinolinadjuvanser til DNA-vacciner
ATE426412T1 (de) Adjuvante influenza-vakzine
CY1112749T1 (el) Εμβολια διεγερσης/αναμνησης κατα της ελονοσιας
DK1459766T3 (da) Adjuvanssammensætninger til forstærkning af immunresponser på polynukleotidbaserede vacciner
DE60228758D1 (de) Immunisierung gegen chlamydia tracheomatis
BRPI0508064A (pt) flavivìrus, composição de vacina e molécula de ácido nucléico
MXPA05009580A (es) Vacuna contra el virus de la influenza.
EA200501890A1 (ru) Вирусы гриппа высокого титра для приготовления вакцин и генной терапии
WO2003059381A3 (en) Immunogenic preparations and vaccines on the basis of mrna
WO2006068663A3 (en) Vaccine compositions for treating coronavirus infection
WO2007075626A3 (en) Immunostimulatory activity of palindromic immune modulatory oligonucleotides (imo tm) contiaining different lengths of palindromic segments
EA201491171A1 (ru) Вещества, содержащие улучшенные генетические конструкции il-12, вакцины, иммунотерапевтические составы и способы их применения
ATE521621T1 (de) Cpg-einzelstrang-desoxynukleotide zur verwendung als adjuvans
WO2005013918A3 (en) Compositions, methods and kits relating to poxvirus subunit vaccines
WO2008048344A3 (en) Bacillus anthracis antigens, vaccine compositions, and related methods
DE60226175D1 (de) Mycobakterieller impfstoff
DK1471936T3 (da) HIV-Vaccine og fremgangsmåde til anvendelse
WO2009074861A3 (en) Improved vaccine
ATE420658T1 (de) Imidazoquinolinamine als adjuvantien für hiv dna vakzine
CY1107845T1 (el) Γενετικα εμβολια με ανοσοενισχυτικο
EP1667634A4 (en) ANTHRAX VACCINE
BRPI0604365A (pt) polipeptìdeo isolado, composição de vacina anti-carrapato de múltiplas espécies, e, uso dos mesmos
DK1553979T3 (da) IHNV-G-fusionsprotein til immunistimulering
ATE460945T1 (de) Genetische adjuvanz-impfstoffe
EP2505212A3 (en) Novel P falciparum vaccine proteins and coding sequences