AU4427897A - 3' genomic promoter region and polymerase gene mutations responsible for att enuation in viruses of the order designated mononegavirales - Google Patents

Description

3' GENOMIC PROMOTER REGION AND POLYMERASE GENE

MUTATIONS RESPONSIBLE FOR ATTENUATION IN VIRUSES

OF THE ORDER DESIGNATED MONONEGAVIRALES

Field Of The Invention

This invention relates to isolated, recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA viruses of the Order designated Mononegavirales having at least one attenuating mutation in the 3 * genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene. This invention was made with Government support under a grant awarded by the Public Health Service. The Government has certain rights in the inventio .

Background Of The Invention

Enveloped, negative-sense, single stranded

RNA viruses are uniquely organized and expressed. The genomic RNA of negative-sense, single stranded viruses serves two template functions in the context of a nucleocapsid: as a template for the synthesis of messenger RNAs (mRNAs) and as a template for the synthesis of the antigenome (+) strand. Negative- sense, single stranded RNA viruses encode and package their own RNA dependent RNA Polymerase . Messenger RNAs are only synthesized once the virus has been uncoated in the infected cell. Viral replication occurs after synthesis of the mRNAs and requires the continuous synthesis of viral proteins . The newly synthesized antigenome (+) strand serves as the template for generating further copies of the (-) strand genomic RNA. The polymerase complex actuates and achieves transcription and replication by engaging the cis- acting signals at the 3' end of the genome, in particular, the promoter region. Viral genes are then transcribed from the genome template unidirectionally from its 3' to its 5' end. There is always less mRNA made from the downstream genes (e.g., the polymerase gene (L) ) relative to their upstream neighbors (i.e., the nucleoprotein gene (N) ) . Therefore, there is always a gradient of mRNA abundance according to the position of the genes relative to the 3 ' -end of the genome.

Based on the revised reclassification in 1993 by the International Committee on the Taxonomy of Viruses, an Order, designated Mononegavirales, has been established. This Order contains three families of enveloped viruses with single stranded, nonsegmented RNA genomes of minus polarity (negative-sense) . These families are the Paramyxoviridae, Rhabdoviridae and Filoviridae. The family Paramyxoviridae has been further divided into two subfamilies, Paramyxovirinae and Pneumovirinae . The subfamily Paramyxovirinae contains three genera, Paramyxovirus , RuJulavirus and Morbillivirus . The subfamily Pneumovirinae contains the genus Pneumov±ruβ . The new classification is based upon morphological criteria, the organization of the viral genome, biological activities and the sequence relationships of the proteins . The morphological distinguishing feature among enveloped viruses for the subfamily Paramyxovirinae is the size and shape of the nucleocapsids (diameter 18mm, 1mm in length, pitch of 5.5 nm) , which have a left-handed helical symmetry. The biological criteria are: 1) antigenic cross-reactivity between members of a genus, and 2) the presence of neuraminidase activity in the genera Paramyxovirus, Ru ulavirus and its absence in genus Moxφilliv±rus . In addition, variations in the coding potential of the P gene are considered, as is the presence of an extra gene (SH) in Rubulaviruses. Pneumoviruses can be distinguished from

Paramyxovirinae morphologically because they contain narrow nucleocapsids . In addition, pneumoviruses have major differences in the number of protein-encoding cistrons (10 in pneumoviruses versus 6 in Paramyxovirinae) and an attachment protein (G) that is very different from that of Paramyxovirinae. Although the paramyxoviruses and pneumoviruses have six proteins that appear to correspond in function (N, P, M, G/H/HN, F and L) , only the latter two proteins exhibit significant sequence relatedness between the two subfamilies. Several pneumoviral proteins lack counterparts in most of the paramyxoviruses, namely the nonstructural proteins NS1 and NS2, the small hydrophobic protein SH, and a second protein M2. Some para yxoviral proteins, namely C and V, lack counterparts in pneumoviruses. However, the basic genomic organization of pneumoviruses and paramyxoviruses is the same. The same is true of rhabdoviruses and filoviruses. Table 1 presents the current taxonomical classification of these viruses, together with examples of each genus.

Table 1 Classification of Nonsegmented, negative-sense, single stranded RNA Viruses of the Order Mononegavirales Family Paramyxoviridae

Subfamily Paramyxovirinae Genus Paramyxovirus

Sendai virus (mouse parainfluenza virus type 1) Human parainfluenza virus (PIV) types 1 and 3

Bovine parainfluenza virus (BPV) type 3 Genus Rubulavirus Simian virus 5 (SV) (Canine parainfluenza virus type 2) Mumps virus

Newcastle disease virus (NDV) (avian Paramyxovirus 1) Human parainfluenza virus types 2, 4a and 4b Genus Morbilliv±rus

Measles virus (MV) Dolphin Morbillivirus Canine distemper virus (CDV)

Peste-des-petits-ruminants virus Phocine distemper virus Rinderpest virus Subfamily Pneumovirinae Genus Pneu ovirus

Human respiratory syncytial virus (RSV) Bovine respiratory syncytial virus Pneumonia virus of mice Turkey rhinotracheitis virus Family Rhabdoviridae

Genus Lyssavirus

Rabies virus Genus Vesiculovirus

Vesicular stomatitis virus Genus Ephemerovirus

Bovine ephemeral fever virus Family Filovirdae

Genus Filovirus

Marburg virus For many of these viruses, no vaccines of any kind are available. Thus, there is a need to develop vaccines against such human and animal pathogens. Such vaccines would have to elicit a protective immune response in the recipient. The qualitative and quantitative features of such a favorable response are extrapolated from those seen in survivors of natural virus infection, who, in general, are protected from reinfection by the same or highly related viruses for some significant duration thereafter.

A variety of approaches can be considered in seeking to develop such vaccines, including the use of: (1) purified individual viral protein vaccines (subunit vaccines) ; (2) inactivated whole virus preparations; and (3) live, attenuated viruses.

Subunit vaccines have the desirable feature of being pure, definable and relatively easily produced in abundance by various means, including recombinant DNA expression methods. To date, with the notable exception of hepatitis B surface antigen, viral subunit vaccines have generally only elicited short-lived and/or inadequate immunity, particularly in naive recipients .

Formalin inactivated whole virus preparations of polio (IPV) and hepatitis A have proven safe and efficacious. In contrast, immunization with similarly inactivated whole viruses such as respiratory syncytial virus and measles virus vaccines elicited unfavorable immune responses and/or response profiles which predisposed vaccinees to exaggerated or aberrant disease when subsequently confronted with the natural or "wild-type^M virus.

Early attempts (1966) to vaccinate young children using a parenterally administered formalin- inactivated RSV vaccine. Unfortunately, several field trials of this vaccine revealed serious adverse reactions -- the development of a severe illness with unusual features following subsequent natural infection with RSV (Bibliography entries 1,2). It has been suggested that this formalinized RSV antigen elicited an abnormal or unbalanced immune response profile, predisposing the vaccinee to RSV disease (3,4).

Thereafter, live, attenuated RSV vaccine candidates were generated by cold passage or chemical mutagenesis. These RSV strains were found to have reduced virulence in seropositive adults. Unfortunately, they proved either over or under- attenuated when given to seronegative infants; in some cases, they also were found to lack genetic stability (5,6). Another vaccination approach using parenteral administration of live virus was ineffective and efforts along this line were discontinued (7) . Notably, these live RSV vaccines were never associated with disease enhancement as observed with the formalin- inactivated RSV vaccine described above. Currently, there are no RSV vaccines approved for administration to humans, although clinical trials are now in progress with cold-passaged, chemically mutagenized strains of RSV designated A2 and B-l. Appropriately attenuated live derivatives of wild- type viruses offer a distinct advantage as vaccine candidates. As live, replicating agents, they initiate infection in recipients during which viral gene products are expressed, processed and presented in the context of the vaccinee' s specific MHC class I and II molecules, eliciting humoral and cell-mediated immune responses, as well as the coordinate cytokine patterns, which parallel the protective immune profile of survivors of natural infection. This favorable immune response pattern is contrasted with the delimited responses elicited by inactivated or subunit vaccines, which typically are largely restricted to the humoral immune surveillance arm. Further, the immune response profile elicited by some formalin inactivated whole virus vaccines, e.g., measles and respiratory syncytial virus vaccines developed in the 1960's, have not only failed to provide sustained protection, but in fact have led to a predisposition to aberrant, exaggerated, and even fatal illness, when the vaccine recipient later confronted the wild- type virus.

While live, attenuated viruses have highly desirable characteristics as vaccine candidates, they have proven to be difficult to develop. The crux of the difficulty lies in the need to isolate a derivative of the wild-type virus which has lost its disease- producing potential (i.e., virulence), while retaining sufficient replication competence to infect the recipient and elicit the desired immune response profile in adequate abundance.

Historically, this delicate balance between virulence and attenuation has been achieved by serial passage of a wild- type viral isolate through different host tissues or cells under varying growth conditions (such as temperature) . This process presumably favors the growth of viral variants (mutants) , some of which have the favorable characteristic of attenuation. Occasionally, further attenuation is achieved through chemical utagenesis as well .

This propagation/passage scheme typically leads to the emergence of virus derivatives which are temperature sensitive, cold-adapted and/or altered in their host range -- one or all of which are changes from the wild-type, disease-causing viruses -- i.e., changes that may be associated with attenuation.

Several live virus vaccines, including those for the prevention of measles and mumps (which are paramyxoviruses) , and for protection against polio and rubella (which are positive strand RNA viruses) , have been generated by this approach and provide the mainstay of current childhood immunization regimens throughout the world. Nevertheless, this means for generating attenuated live virus vaccine candidates is lengthy and, at best, unpredictable, relying largely on the selective outgrowth of those randomly occurring genomic mutants with desirable attenuation characteristics. The resulting viruses may have the desired phenotype in vi tro , and even appear to be attenuated in animal models. However, all too often they remain either under- or overattenuated in the human or animal host for whom they are intended as vaccine candidates. Even as to current vaccines in use, there is still a need for more efficacious vaccines. For example, the current measles vaccines provide reasonably good protection. However, recent measles epidemics suggest deficiencies in the efficacy of current vaccines. Despite maternal immunization, high rates of acute measles infection have occurred in children under age one, reflecting the vaccines' inability to induce anti-measles antibody levels comparable to those developed following wild-type measles infection (8,9,10). As a result, vaccine- immunized mothers are less able to provide their infants with sufficient transplacentally-derived passive antibodies to protect the newborns beyond the first few months of life. Acute measles infections in previously immunized adolescents and young adults point to an additional problem. These secondary vaccine failures indicate limitations in the current vaccines' ability to induce and maintain antiviral protection that is both abundant and long-lived (11,12,13). Recently, yet another potential problem was revealed. The hemagglutinin protein of wild-type measles isolated over the past 15 years has shown a progressively increasing distance from the vaccine strains (14) .

This "antigenic drift" raises legitimate concerns that the vaccine strains may not contain the ideal antigenic repertoire needed to provide optimal protection. Thus, there is a need for improved vaccines. Rational vaccine design would be assisted by a better understanding of these viruses, in particular, by the identification of the virally encoded determinants of virulence as well as those genomic changes which are responsible for attenuation.

Summary Of The Invention

Accordingly, it is an object of this invention to identify those regions of the genome of the RNA viruses of the Order Mononegavirales where mutations result in attenuation of those viruses.

It is a further object of this invention to produce recombinantly-generated viruses which incorporate such attenuating mutations in their genomes .

It is still a further object of this invention to formulate vaccines containing such attenuated viruses .

These and other objects of the invention as discussed below are achieved by the generation and isolation of recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA viruses of the Order Mononegavirales having at least one attenuating mutation in the 3 ' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene.

In the case of measles virus, at least one attenuating mutation in the 3 ' genomic promoter region is selected from the group consisting of nucleotide 26 (A → T) , nucleotide 42 (A → T or A → C) and nucleotide 96 (G - A) , where these nucleotides, as well as others delineated in this application (unless stated otherwise) , are presented in positive strand, antigenomic, that is, message (coding) sense, and at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 331 (isoleucine — > threonine) , 1409 (alanine -» threonine) , 1624 (threonine —> alanine) , 1649 (arginine — > methionine) , 1717 (aspartic acid — alanine) , 1936 (histidine -> tyrosine) , 2074 (glutamine — arginine) and 2114 (arginine - lysine) .

In the case of human parainfluenza virus type 3, at least one attenuating mutation in the 3' genomic promoter region is selected from the group consisting of nucleotide 23 (T — > C) , nucleotide 24 (C -> T) , nucleotide 28 (G - T) and nucleotide 45 (T - A) , and at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 942 (tyrosine —> histidine) , 992 (leucine —» phenylalanine) , 1292 (leucine —> phenylalanine) , and 1558 (threonine —» isoleucine) .

In the case of human respiratory syncytial virus subgroup B, at least one attenuating mutation in the 3 ' genomic promoter region is selected from the group consisting of nucleotide 4 (C — G) and the insertion of an additional A in the stretch of A's at nucleotides 6-11, and at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 353 (arginine — > lysine) , 451 (lysine — arginine) , 1229 (aspartic acid — asparagine) , 2029 (threonine —> isoleucine) and 2050 (asparagine —► aspartic acid) .

In another embodiment of this invention, attenuated virus is used to prepare vaccines which elicit a protective immune response against the wild- type form of the virus . In yet another embodiment of this invention, an isolated, positive strand, antigenomic message sense nucleic acid molecule (or an isolated, negative strand genomic sense nucleic acid molecule) having the complete viral nucleotide sequence (whether of wild- type virus or virus attenuated by non-recombinant means) is manipulated by introducing one or more of the attenuating mutations described in this application to generate an isolated, recombinantly-generated attenuated virus. This virus is then used to prepare vaccines which elicit a protective immune response against the wild-type form of the virus.

In still another embodiment of this invention, such a complete wild- type or vaccine viral nucleotide sequence is used: (1) to design PCR primers for use in a PCR assay to detect the presence of the corresponding virus in a sample; or (2) to design and select peptides for use in an ELISA to detect the presence of the corresponding virus in a sample.

Brief Description Of The Figures

Figure 1 depicts the passage history of the Editionston measles virus (15) . The abbreviations have the following meanings: HK - human kidney; HA - human amnion; CE(am) - chick embryo; CEF - chick embryo fibroblast; DK - dog kidney; WI-38 - human diploid cells; SK - sheep kidney; * - plaque cloning. The number following each abbreviation represents the number of passages . Figure 2 depicts a map of the measles virus genome showing putative cis-acting regulatory elements at and near the genome and antigenome termini. Top - a schematic map of the measles virus genome, beginning at the 3 ' end with 52 nucleotides of leader sequence (1) and ending at the 5' terminus with 37 nucleotides of trailer sequence (t) . Gene boundaries are denoted by vertical bars; below each gene is the number of cistronic nucleotides. Bottom - an expanded schematic view of the 3 ' extended genomic promoter regions of genome and antigenome, showing the position and sequence of the two highly conserved domains, A and B. The intervening intergenic trinucleotide is denoted as well. Nascent 5' RNAs encompassing the A' to B* regions are presumed to contain the regulatory sequence at which the N protein encapsidation initiates.

Figure 3 depicts a genetic map of the RSV subgroup B wild- type strains designated 2B and 18537 (top portion) , the intergenic sequences of those strains (middle portion) and the 68 nucleotide overlap between the M2 and L genes (bottom portion) . The RSV 2B stain has six fewer nucleotides in the G gene, encoding two fewer amino acid residues in the G protein, as compared to the 18537 strain. The 2B strain has 145 nucleotides in the 5' trailer region, as compared to 149 nucleotides in the 18537 strain. The 2B strain has one more nucleotide in each of the NS-1, NS-2 and N genes, and one fewer nucleotide in each of the M and F genes, as compared to the 18537 strain.

Detailed Description Of The Invention

Transcription and replication of negative- sense, single stranded RNA viral genomes are achieved through the enzymatic activity of a multimeric protein acting on the ribonucleoprotein core (nucleocapsid) .

Naked genomic RNA cannot serve as a template. Instead, these genomic sequences are recognized only when they are entirely encapsidated by the N protein into the nucleocapsid structure. It is only in that context that the genomic and antigenomic terminal promoter sequences are recognized to initiate the transcriptional or replication pathways .

All paramyxoviruses require the two viral proteins, L and P, for these polymerase pathways to proceed. The pneumoviruses, including RSV, also require the transcription elongation factor, M2, for the transcriptional pathway to proceed efficiently. Additional cofactors may also play a role, including perhaps the virus-encoded NSl and NS2 proteins, as well as perhaps host-cell encoded proteins.

However, considerable evidence indicates that it is the L protein which performs most, if not all, the enzymatic processes associated with transcription and replication, including initiation, and termination of ribonucleotide polymerization, capping and polyadenylation of mRNA transcripts, methylation and perhaps specific phosphorylation of P proteins. The L protein's central role in genomic transcription and replication is supported by its large size, sensitivity to mutations, and its catalytic level of abundance in the transcriptionally active viral complex (16) .

These considerations led to the proposal that L proteins consist of a linear array of domains whose concatenated structure integrates discrete functions (17) . Indeed, three such delimited, discrete elements within the negative-sense virus L protein have been identified based on their relatedness to defined functional domains of other well-characterized proteins. These include: (1) a putative RNA template recognition and/or phosphodiester bond formation domain; (2) an RNA binding element; and (3) an ATP binding domain. All prior studies of L proteins of nonsegmented negative-sense, single stranded RNA viruses have revealed these putative functional elements (17) .

Without being bound by the following, it is reasonable to presume that these non-protein coding, promoter and other cis-acting genomic regulatory domains are important determinants of the efficiency with which transcription and replication by measles virus (MV) and other viruses of the Order Mononegavirales are actualized, in association with the L protein, and that they may therefore be virulence determinants for these viruses as well. In summary, the invention is believed to encompass a coordinate set of changes between the cis- acting regulatory signal (3' genomic promoter region) and the polymerase gene (L) which results in attenuation of the virus while retaining sufficient ability of the virus to replicate. Attenuation is optimized by rational mutations of the 3 ' genomic promoter region and the polymerase gene, which provide the desired balance of replication efficiency: so that the virus vaccine is no longer able to produce disease, yet retains its capacity to infect the vaccinee' s cells, to express sufficiently abundant gene products to elicit the full spectrum and profile of desirable immune responses, and to reproduce and disseminate sufficiently to maximize the abundance of the immune response elicited.

Without being bound by the following, attenuating mutations in the extended promoter (3 * genomic promoter region) and in the polymerase gene are believed to affect the display of cis-acting signals and the conformation of the polymerase complex engaging these signals. For example, when encapsidated, the promoter RNA is coiled in a helical array. Changes in promoter sequence may affect the relative positions at which the conserved signals are displayed relative to one another. Specifically, the measles wild-type 3' genomic promoter region has a pyrimidine (uracil) at positions 26 and 42 (the antigenomic message sense sequences have the purine adenine) . The vaccine strains have purines at those positions (the antigenomic message sense sequences have the corresponding pyrimidines; see Table 3 in Example 1 below) . The larger purines may change the distance and/or angular display between the conserved domains of the promoter (e.g, in measles, positions 1-11 and 87- 98) , resulting in an altered spatial presentation of the cis-acting signals to the polymerase.

Animal studies have demonstrated a decrease in viral replication sufficient to avoid illness but adequate to elicit the desired immune response. This likely represents a decrease in transcription, a decrease in gene expression of virally encoded proteins, a decrease in antisense templates and, therefore, the production of fewer new genomes. The resulting attenuated viruses are significantly less virulent than the wild- type.

The attenuating mutations described herein may be introduced into viral strains by two methods :

(1) Conventional means such as chemical mutagenesis during virus growth in cell cultures to which a chemical mutagen has been added, selection of virus that has been subjected to passage at suboptimal temperature in order to select temperature sensitive and/or cold adapted mutations, identification of mutant virus that produce small plaques in cell culture, and passage through heterologous hosts to select for host range mutations . These viruses are then screened for attenuation of their biological activity in an animal model. Attenuated viruses are subjected to nucleotide sequencing of their 3 ' genomic promoter region and polymerase genes to locate the sites of attenuating mutations. Once this has been done, method (2) is then carried out.

(2) A preferred means of introducing attenuating mutations comprises making predetermined mutations using site-directed mutagenesis. These mutations are identified either by method (1) or by reference to closely-related viruses whose attenuating mutations are already known. One or more mutations are introduced into each of the 3 ' genomic promoter region and the polymerase gene. Cumulative effects of different combinations of coding and non-coding changes can also be assessed.

The mutations to the 3 ' genomic promoter region and polymerase gene are introduced by standard recombinant DNA methods into a DNA copy of the viral genome. This may be a wild-type or a modified viral genome background (such as viruses modified by method (1)), thereby generating a new virus. Infectious clones or particles containing these attenuating mutations are generated using the cDNA "rescue" system, which has been applied to a variety of viruses, including Sendai virus (18) ; measles virus (19) ; respiratory syncytial virus (20) ; rabies (21) ; vesicular stomatitis virus (VSV) (15) ; and rinderpest virus (23); these references are hereby incorporated by reference. See, for measles virus rescue, published International patent application WO 97/06270, designating the United States (24) ; for PIV-3 rescue, U.S. provisional patent application 60/047575 (25); for RSV rescue, published International patent application WO 97/12032, designating the United States (26); these applications are hereby incorporated by reference.

Briefly, all Mononegavirales rescue systems can be summarized as follows: Each requires a cloned DNA equivalent of the entire viral genome placed between a suitable DNA-dependent RNA polymerase promoter (e.g., the T7 RNA polymerase promoter) and a self-cleaving ribozyme sequence (e.g., the hepatitis delta ribozyme) which is inserted into a propagatable bacterial plasmid. This transcription vector provides the readily manipulable DNA template from which the RNA polymerase (e.g., T7 RNA polymerase) can faithfully transcribe a single-stranded RNA copy of the viral antigenome (or genome) with the precise, or nearly precise, 5' and 3' termini. The orientation of the viral genomic DNA copy and the flanking promoter and ribozyme sequences determine whether antigenome or genome RNA equivalents are transcribed. Also required for rescue of new virus progeny are the virus-specific trans-acting proteins needed to encapsidate the naked, single-stranded viral antigenome or genome RNA transcripts into functional nucleocapsid templates: the viral nucleocapsid (N or NP) protein, the polymerase-associated phosphoprotein (P) and the polymerase (L) protein. These proteins comprise the active viral RNA-dependent RNA polymerase which must engage this nucleocapsid template to achieve transcription and replication.

The trans-acting proteins required for measles virus rescue are the encapsidating protein N, and the polymerase complex proteins, P and L. For PIV- 3, the encapsidating protein is designated NP, and the polymerase complex proteins are also referred to as P and L. For RSV, the virus-specific trans-acting proteins include N, P and L, plus an additional protein, M2, the RSV-encoded transcription elongation factor.

Typically, these viral trans-acting proteins are generated from one or more plasmid expression vectors encoding the required proteins, although some or all of the required trans-acting proteins may be produced within mammalian cells engineered to contain and express these virus-specific genes and gene products as stable transformants . The typical (although not necessarily exclusive) circumstances for rescue include an appropriate mammallian cell milieu in which T7 polymerase is present to drive transcription of the antigenomic (or genomic) single-stranded RNA from the viral genomic cDNA-containing transcription vector.

Either cotranscriptionally or shortly thereafter, this viral antigenome (or genome) RNA transcript is encapsidated into functional templates by the nucleocapsid protein and engaged by the required polymerase components produced concurrently from co- transfected expression plasmids encoding the required virus-specific trans-acting proteins. These events and processes lead to the prerequisite transcription of viral mRNAs, the replication and amplification of new genomes and, thereby, the production of novel viral progeny, i.e., rescue.

For the rescue of rabies, VSV and Sendai, T7 polymerase is provided by recombinant vaccinia virus VTF7-3. This system, however, requires that the rescued virus be separated from the vaccinia virus by physical or biochemical means or by repeated passaging in cells or tissues that are not a good host for poxvirus. For MV cDNA rescue, this requirement is avoided by creating a cell line that expresses T7 polymerase, as well as viral N and P proteins. Rescue is achieved by transfecting the genome expression vector and the L gene expression vector into the helper cell line. Advantages of the host-range mutant of the vaccinia virus, MVA-T7, which expresses the T7 RNA polymerase, but does not replicate in mammalian cells, are exploited to rescue RSV, Rinderpest virus and MV. After simultaneous expression of the necessary encapsidating proteins, synthetic full length antigenomic viral RNA are encapsidated, replicated and transcribed by viral polymerase proteins and replicated genomes are packaged into infectious virions . In addition to such antigenomes, genome analogs have now been successfully rescued for Sendai and PIV-3 (25,27). The rescue system thus provides a composition which comprises a transcription vector comprising an isolated nucleic acid molecule encoding a genome or antigenome of a nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales having at least one attenuating mutation in the 3 ' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene, together with at least one expression vector which comprises at least one isolated nucleic acid molecule encoding the transacting proteins necessary for encapsidation, transcription and replication (e.g., N, P and L for measles virus; NP, P and L for PIV-3; N, P, L and M2 for RSV) . Host cells are then transformed or transfected with the at least two expression vectors just described. The host cells are cultured under conditions which permit the co-expression of these vectors so as to produce the infectious attenuated virus .

The rescued infectious virus is then tested for its desired phenotype (temperature sensitivity, cold adaptation, plaque morphology, and transcription and replication attenuation), first by in vi tro means. The mutations at the cis-acting 3 ' genomic promoter region are also tested using the minireplicon system where the required trans-acting encapsidation and polymerase activities are provided by wild-type or vaccine helper viruses, or by plasmids expressing the N, P and different L genes harboring gene-specific attenuating mutations (19,28).

If the attenuated phenotype of the rescued virus is present, challenge experiments are conducted with an appropriate animal model. Non-human primates provide the preferred animal model for the pathogenesis of human disease. These primates are first immunized with the attenuated, recombinantly-generated virus, then challenged with the wild-type form of the virus. Monkeys are infected by various routes, including but not limited to intranasal, intratracheal or subcutaneous routes of inoculation (29) . Experimentally infected rhesus and cynomolgus macaques have also served as animal models for studies of vaccine-induced protection against measles (30) . Protection is measured by such criteria as disease signs and symptoms, survival, virus shedding and antibody titers. If the desired criteria are met, the attenuated, recombinantly-generated virus is considered a viable vaccine candidate for testing in humans. The "rescued" virus is considered to be "recombinantly- generated", as are the progeny and later generations of the virus, which also incorporate the attenuating mutations.

Even if a "rescued virus is underattenuated or overattenuated relative to optimum levels for vaccine use, this is information which is valuable for developing such optimum strains. Optimally, a codon containing an attenuating point mutation may be stabilized by introducing a second or a second plus a third mutation in the codon without changing the amino acid encoded by the codon bearing only the attenuating point mutation. Infectious virus clones containing the attenuating and stabilizing mutations are also generated using the cDNA "rescue" system described above.

Measles virus serves as a useful model for this invention, because sequence data are now available as described herein for the disease-causing wild- type virus and for the disease-preventing vaccines which have a demonstrated history of efficacy.

Measles virus was first isolated in tissue culture in 1954 (31) from an infected patient named David Editionston. This Edmonston strain of measles became the progenitor for many live-attenuated measles vaccines including Moraten, which is the current vaccine in the United States (Attenuvax™; Merck Sharp & Dohme, West Point, PA) and was licensed in 1968 and has proven to be efficacious. Aggressive immunization programs instituted in the mid to late 1960s resulted in the precipitous drop in reported measles cases from near 700,000 in 1965 to 1500 in 1983. In parallel, other vaccine strains were also developed from the Editionston strain

(see Fig. 1), Schwarz (Institut Merieux, Lyon, France), Zagreb (Zagreb, Yugoslavia) and AIK-C (Japan) . These other vaccines have also proven to be efficacious and have been used extensively. An early, reactogenic, underattenuated vaccine strain (Rubeovax™: Merck Sharp & Dohme) produced measles-like illness in children and its use thus was discontinued. It, however, was further attenuated successfully to produce the Moraten vaccine strain (see Fig. 1) (32) . Live measles virus vaccine provides a success story of the development of an efficacious vaccine and provides a model for understanding the molecular mechanisms of viral vaccine attenuation among nonsegmented, negative-sense, single stranded RNA viruses. Because of its significance as a major cause of human morbidity and mortality, measles virus (MV) has been quite extensively studied. MV is a large, relatively spherical, enveloped particle composed of two compartments, a lipoprotein membrane and a ribonucleoprotein particle core, each having distinct biological functions (33) . The virion envelope is a host cell-derived plasma membrane modified by three virus-specified proteins: The hemagglutinin (H; approximately 80 kilodaltons (kD) ) and fusion (F₁₂; approximately 60 kD) glycoproteins project on the virion surface and confer host cell attachment and entry capacities to the viral particle (16) . Antibodies to H and/or F are considered protective since they neutralize the virus' ability to initiate infection (34,35,36). The matrix (M; approximately 37 kD) protein is the amphipathic protein lining the membrane's inner surface, which is thought to orchestrate virion morphogenesis and thus consummate virus reproduction (37) . The virion core contains the 15,894 nucleotide long genomic RNA upon which template activity is conferred by its intimate association with approximately 2600 molecules of the approximately 60 kD nucleocapsid (N) protein (38,39,40). Loosely associated with this approximately one micron long helical ribonucleoprotein particle are enzymatic levels of the viral RNA dependent RNA polymerase (L; approximately 240 kD) which in concert with the polymerase cofactor (P; approximately 70 kD) , and perhaps yet other virus-specified as well as host-encoded proteins, transcribes and replicates the MV genome sequences (41) .

To date, the entire nucleotide sequences (only for the Edmonston B laboratory strain and the AIK-C vaccine strain) , coding potential, and organization of the MV genome have been reported (33) . The six virion structural proteins are encoded by six contiguous, non-overlapping genes which are arrayed as follows: 3 ' -N-P-M-F-H-L-5 ' . Two additional MV gene products of as yet uncertain function have also been identified. These two nonstructural proteins, known as C (approximately 20 kD) and V (approximately 45 kD) , are both encoded by the P gene, the former by a second reading frame within the P mRNA; the latter by a cotranscriptionally edited P gene-derived mRNA which encodes a hybrid protein having the amino terminal sequences of P and a new zinc finger-like cysteine-rich carboxy terminal domain (16) .

In addition to the sequences encoding the virus-specified proteins, the MV genome contains distinctive non-protein coding domains resembling those directing the transcriptional and replicative pathways of related viruses (16,42). These regulatory signals lie at the 3 ' and 5 ' ends of the MV genome and in short internal regions spanning each intercistroniσ boundary. The former encode the putative promoter and/or regulatory sequence elements directing genomic transcription, genome and antigenome encapsidation, and replication. The latter signal transcription termination and polyadenylation of each monocistronic viral mRNA and then reinitiation of transcription of the next gene. In general, the MV polymerase complex appears to respond to these signals much as the RNA-dependent RNA polymerases of other non-segmented negative strand RNA viruses (16,42,43,44). Transcription initiates at or near the 3' end of the MV genome and then proceeds in a 5 ' direction producing monocistronic mRNAs (40,42,45). As the polymerase traverses the MV genomic template, it encounters putative stop/start signals which, in 3 ' to 5' order, are: a semi-conserved transcription termination/polyadenylation signal (A/G U/C UA A/U NN A₄, where N may be any of the four bases) at which each monocistronic RNA is completed; a non-transcribed intergenic trinucleotide punctuation mark (CUU; except at the H:L boundary where it is CGU) ; and a semiconserved start signal for transcription initiation of the next gene (AGG A/G NN C/A A A/G G A/U, where N may be any of the four bases) (45,46). Since some polymerase complexes fail to reinitiate, the abundance of each MV mRNA diminishes in parallel with the distance of the encoding gene from the genomic 3 ' end. This mRNA gradient directly corresponds to the relative abundance of each virus-specified protein. This indicates that MV protein expression is ultimately controlled at the transcriptional level (44) . The 3 ' and 5 ' MV genomic termini contain non-protein coding sequences with distinct parallels to the leader and trailer RNA encoding regions of VSV (42) . Nucleotides 1-55 define the region between the genomic 3' terminus and the beginning of the N gene, while 37 additional nucleotides can be found between the end of the L gene and the 5 ' terminus of the genome. However, unlike VSV, or even the paramyxoviruses Sendai and NDV, MV does not transcribe these terminal regions into short, unmodified (+) or (-) sense leader RNAs (47,48,49) . Instead, leader readthrough transcripts, including full-length polyadenylated leader :N, leader:N:P, leader:N:P:M, and of course full-length antigenome MV RNAs are transcribed (48,49). Thus, the short leader transcript, the key operational element determining the switch from transcription to replication of the VSV single- stranded, negative polarity genome (50,51,52), seems absent in MV. This leads to consideration and exploration of alternative models for this crucial reproductive event (42) .

Measles virus, as well as all other Mononegavirales except the rhabdoviruseβ, appears to have extended its terminal regulatory domains beyond the confines of leader and trailer encoding sequences (42) . For measles, these regions encompass the 107 3' genomic nucleotides (the "3' genomic promoter region", also referred to as the "extended promoter", which comprises 52 nucleotides encoding the leader region, followed by three intergenic nucleotides, and 52 nucleotides encoding the 5 ' untranslated region of N mRNA) and the 109 5' end nucleotides (69 encoding the 3 ' untranslated region of L mRNA, the intergenic trinucleotide and 37 nucleotides encoding the trailer) . Within these 3* terminal approximately 100 nucleotides of both the genome and antigenome are two short regions of shared nucleotide sequence: 14 of 16 nucleotides at the absolute 3 ' ends of the genome and antigenome are identical. Internal to those termini, an additional region of 12 nucleotides of absolute sequence identity have been located. Their position at and near the sites at which the transcription of the MV genome must initiate and replication of the antigenome must begin, suggests that these short unique sequence domains encompass an extended promoter region.

These discrete sequence elements may dictate alternative sites of transcription initiation -- the internal domain mandating transcription initiation at the N gene start site, and the 3* terminal domain directing antigenome production (42,48,53). In addition to their regulatory role as cis-acting determinants of transcription and replication, these 3* extended genomic and antigenomic promoter regions encode the nascent 5 ' ends of antigenome and genome RNAs, respectively. Within these nascent RNAs reside as yet unidentified signals for N protein nucleation, another key regulatory element required for nucleocapsid template formation and consequently for amplification of transcription and replication. Figure 2 schematically shows the location and sequence of these highly conserved, putative cis-acting regulatory domains .

Terminal non-protein coding regions similar in location, size and spacing are present in the genomes of other members of the genus Paramyxoviridae , though only 8-11 of their absolute terminal nucleotides are shared by MV (42,54) . The genomic terminii of the -brbillivirus canine distemper virus (CDV) displays a greater degree of homology with its MV relative: 73% of the nucleotides of the leader and trailer sequences of these two viruses are identical, including 16 of 18 at the absolute 3' termini and 17 of 18 at their 5' ends (55) . No accessory internal CDV genomic domain- sharing homology to that of the MV extended promoter has been found. However, there is a 20 nucleotide long stretch lying between CDV genomic nucleotides 85 and 104 and 15,587 and 15,606 in which 15 of the 20 nucleotides are complementary (Gene Bank accession number AF 14953) . This indicates that CDV, like MV contains an additional region within its non-coding 3' genomic and antigenomic ends that may provide important cis-acting promoter and/or regulatory signals (55) .

Additionally, the precise length of the 3 ' - leader region (55 nucleotides) is identical among several members of the Family Paramyxoviridae (MV, CDV, PIV-3, BPV-3, SV and NDV). Further evidence for the importance of these extended, non-protein coding regions comes from analyses of a large number of distinct copy-back Defective Interfering Viruses (DIs) recently cloned from subacute sclerosing panencephalitis (SSPE) brain tissue. No DI with a stem shorter than the 95 5 ' terminal genomic nucleotides was found. This indicates that the minimal signals needed for MV DI RNA replication and encapsidation extend well beyond the 37 nucleotide long trailer sequence to encompass the additional internal putative regulatory domain (56) .

As exemplified in part by measles virus, this invention is directed to the concept that important virulence/attenuation determinants reside in viral genomic non-protein coding regulatory regions and in the transacting transcription/replication enzyme complex with which these cis-acting elements must interact. The cis-acting domains are found both at the 3' and 5' ends of the MV genome, flanking the six contiguous genes encoding viral structural proteins; and within the MV genome as short regions encompassing internal intergenic boundaries . The former encode the putative promoter and/or regulatory sequence elements directing the vital processes of genomic transcription, genome and antigenome encapsidation, and replication. The latter signal transcription termination and polyadenylation of each monocistronic viral mRNA and then reinitiation of transcription of the next gene. The transcription/replication enzyme, RNA dependent RNA polymerase molecule can modulate transcription and/or replicative efficiency, thereby determining the abundance of cytopathic viral gene products and/or virion progeny. Proof of the concept of this invention for measles virus is obtained by first determining the nucleotide sequences of the non-coding regulatory regions (3¹ genomic promoter region) and the coding regions of the L gene (with predicted amino acid sequences) of the progenitor Editionston wild-type MV isolate, together with available measles vaccine strains derived from this isolate (see Figure 1) . Independent other wild-type isolates were examined for comparative purposes as well . The nucleotide sequences (in positive strand, antigenomic, message sense) of four wild-type and five vaccine measles strains, as well as the deduced amino acid sequences of the RNA polymerase (L protein) of these measles viruses, are set forth as follows with reference to the appropriate SEQ ID NOS. contained herein: Virus Nucleotide Sequence L Protein Sequence Wild-Type Editions ton SEQ ID NO:l SEQ ID NO: 2 1977 SEQ ID NO: 3 SEQ ID NO: 4 1983 SEQ ID NO: 5 SEQ ID NO: 6 Montef iore SEQ ID NO: 7 SEQ ID NO: 8

Vaccine

Rubeovax^TI SEQ ID NO: 9 SEQ ID NO: 10

Moraten SEQ ID NO: 11 SEQ ID NO: 12

Zagreb SEQ ID NO: 13 SEQ ID NO: 14

AIK-C SEQ ID NO: 15 SEQ ID NO: 16

Each measles virus genome listed above is 15,894 nucleotides in length. Translation of the L gene starts with the codon at nucleotides 9234-9236; the translation stop codon is at nucleotides 15783- 15785. The translated L protein is 2,183 amino acids long.

Note that nucleotide 2499 of 1983 wild-type measles virus is indicated as "G" in SEQ ID NO: 5. In fact, the base is actually a mixture of ^WG" and ^WC" . Also note that nucleotide 2143 of Rubeovax™ vaccine virus is indicated as "T" in SEQ ID NO: 9. In nine clones sequenced, this base was "T" in seven and ^WC" in two; thus, this base can be ^MT" or "C" .

In addition, the Schwarz vaccine virus genome is identical to that of the Moraten vaccine virus genome (SEQ ID NO:ll), except that at nucleotides 4917 and 4924, Schwarz has a ^WC" instead of a "T" .

Nucleotide differences distinguishing the 3 ' genomic promoter region and nucleotide and amino acid differences distinguishing the L gene and L protein sequences of the Edmonston wild- type isolate, vaccine strains and other independently isolated wild- type viruses were then compared and aligned (see Tables 3-5 in Example 1 below) .

As shown in Table 3, there were three mutations from the 3 ' genomic promoter region (in antigenomic, message sense) of the progenitor wild-type MV isolate and the derivative vaccine strains: At nucleotide position 26, from "A" to "T"; at position 42, from "A" to "C" or from "A" to "T"; and in the case of Zagreb only, at position 96, from "G" to "A". In addition, the other examined wild- type isolates differed from both the progenitor wild- type isolate and the vaccine strains at position 50 by having "A" instead of "G" .

The predicted amino acid sequences of the L genes of measles vaccine strains (Rubeovax™, Moraten, Schwarz, AIK-C and Zagreb) and wild- type isolates (1977, 1983 and Montefiore), differ from the progenitor strain (Edmonston) at 49 positions in the 2183 amino acid long open reading frame (see Tables 4 and 5 in Example 1 below) .

These amino acid differences can be divided into four categories :

(1) Positions where one vaccine strain differs from the progenitor, as well as from other vaccine and wild-type strains, suggesting a potential attenuation site.

(2) Specific differences between all wild- type and all vaccine sequences; these may also constitute important attenuation sites. 3) Residues where chronologically newer wild- types differ from older wild- types; which may be attributable to genetic drift.

(4) Positions where one or more vaccine strains and/or wild- type strains have common amino acids and differ from all the other strains; these changes may represent lineage-specific, potentially attenuating changes within the vaccine strains and relatedness among the wild- ype isolates, respectively. There were four category (1) changes where one vaccine differed from the other vaccines, as well as the wild-type strains. Two of these were in Moraten and Schwarz (amino acids 331 and 2114) and two were in AIK-C (1624 and 2074) . These mutations are of special interest because all of these viruses are good vaccines. Thus, these positions are sites for attenuation.

Only one position, 1717, fits into category (2), with all wild-types having aspartic acid and all vaccines having alanine. Interestingly, this position is in one of two areas where the L genes of measles and canine distemper virus (which are otherwise highly homologous) do not show exceptional conservation. This difference makes it more likely that 1717 is a key position for an attenuating mutation in measles. There were five positions, 149, 636, 720,

2017 and 2119, where both chronologically newer wild- types (1983 and Montefiore) differ from older wild- types (Edmonston and 1977) , which therefore fit into category (3) . These differences suggest genetic drift rather than denoting sites of attenuating mutations. Not included in this total are 16 positions where Montefiore (the 1989 isolate) differed from the rest (see Table 5) . These could be either genetic drift (category (3)) or random change (category (4)). The remaining 23 positions are category (4) , with one or more of the viruses differing from the consensus.

Three of these positions (1409, 1649, 1936) are potentially attenuating category (4) mutations. These are changes where two vaccine strains have a common change from the progenitor wild-type strain. These changes may be connected with the vaccine lineage leading to the Rubeovax™ and Moraten vaccines (Figure 1).

Applicants have found that their AIK-C vaccine strain nucleotide sequence differs from the published sequence (33) at 21 positions, including one insertion and one deletion. Several of these differences result in coding changes including two in the L gene (at amino acids 1477 and 2008) . Thus, the additional changes accrued within the L gene sequence as the measles progenitor strain is progressively attenuated to achieve a replicative capacity optimized for live vaccine purposes appears to be constrained and delimited. Presumably, this limited tolerance in the number and location of L gene changes is imposed not only by the need to preserve the multifunctional capacities of the polymerase, but also by the preexisting 3' promoter changes with which the evolving L protein must interact to achieve transcription and replication. In other words, optimal virus attenuation requires coordinate (i.e., linked) changes in the polymerase protein and the cis-acting regulatory elements on which it acts.

The 3 '-leader displays the least tolerance for change, allowing highly selected changes during the attenuation process at nucleotide position 26 (always the change of from "A" to "T"), and at position 42 (the change of from "A" to "C" or from "A" to "T") (in antigenomic, message sense) . In the case of Zagreb only, there is a single further change, from "G" to "A" at position 96, which may be important when combined with Zagreb L gene-specific changes. The 3 ' -leader region seems to have undergone only one instance of genetic drift since 1954, with a change of "G" to "A" at position 50 (see Table 3) . The net change in the 3 ' genomic promoter region during the attenuation process is the replacement of two pyrimidines by two purines in genomic sense in all MV vaccine strains. The co- evolution of the L gene during these attenuation processes is believed to reflect selection of subtle changes favoring reproduction of the viruses in different host cells. All the vaccine strains were grown in chick embryo (CE) or chick embryo fibroblast (CEF) cells during their attenuation process (Figure 1) . In addition, some vaccine strains have been exposed to unique host cells; i.e., Zagreb vaccine was grown in dog kidney cells and human diploid cells, while the AIK-C vaccine was adapted to sheep kidney cells. Moraten and Rubeovax™ were exclusively developed in CE and CEF.

Some of the lineage- specific L gene changes (position 1649 in Rubeovax™, Moraten and Schwarz vaccines and the change at position 1717 in all vaccines) represent a subset of adaptations of the L gene to the 3 '-leader to modulate the transcription/replication processes for vaccine attenuation. Additionally, individual vaccine-specific changes (category (1) ) may provide additional fine tune modulation of virus replication/transcription for each vaccine strain.

Based on Table 3 and the foregoing discussion, the key attenuating mutations for the MV 3 ' genomic promoter region are nucleotide 26 (A — > T) , nucleotide 42 (A → T or A → C) and nucleotide 96 (G → A) (in antigenomic, message sense) .

Based on Table 4 and the foregoing discussion, the key attenuating sites for the L protein are as follows: amino acid residues 331 (isoleucine -» threonine) , 1409 (alanine - threonine) , 1624 (threonine — alanine) , 1649 (arginine —» methionine) , 1717 (aspartic acid —> alanine) , 1936 (histidine -» tyrosine), 2074 (glutamine -> arginine) and 2114 (arginine — > lysine) . It is understood that the nucleotide changes responsible for these amino acid changes are not limited to those set forth in Table 4 of Example 1 below; all changes in nucleotides which result in codons which are translated into these amino acids are within the scope of this invention. Human parainfluenza virus type 3 (HPIV-3) is another nonsegmented, negative-sense, single stranded enveloped RNA virus. HPIV-3 belongs to the Family Paramyxoviridae (see Table 1) . The genome of HPIV-3 is 15,462 nucleotides long and encodes six non-overlapping protein-encoding genes (57) . Five of the genes encode a single virion structural protein each, which are designated NP (corresponding to the N protein of MV) , M, F, HN (hemagglutinin-neura inidase) and L. The sixth mRNA encodes the P protein, and by an overlapping 5 ' proximal open reading frame (ORF) encodes the C protein, and by the RNA editing mechanism, also encodes the D protein.

Like MV, HPIV-3 consists of a 3 ^■ -nonprotein coding leader region of 55 nucleotides, but unlike measles (where it is 37 nucleotides) , it has a 44 nucleotide long 5' -trailer region. The polymerase transcribes the genome in a linear, sequential, start- stop manner which is guided by transcription signals in the RNA template . Attempts to develop a live attenuated HPIV-3 vaccine by passaging the wild-type virus JS strain through cell culture at sub-optimal temperature has produced promising results (7,57). Several "cold passage" (cp) mutants were isolated for evaluation from different passage levels of the JS strain. One such mutant resulted from 45 serial passages and was designated cp45.

This virus exhibited three interesting properties: (1) cold adaptation (ca) : the ability to replicate efficiently at the suboptimal temperature of 20°C; (2) temperature sensitivity (ts) : inability to replicate in vi tro at temperatures greater than or equal to 39°C; and (3) small plaque morphology. This mutant appeared to be a promising vaccine candidate because: (a) its ca , ts and small plaque phenotype is stable after passage in cell culture; (b) its replication is restricted in both the upper and lower respiratory tract of hamsters; and (c) it induced significant protection in hamsters against subsequent challenge with wild- type HPIV-3 (58,59).

Evaluation of this strain in the rhesus monkey showed the attenuation mutations in cp45 to be a combination of ts and non-ts mutations (60) . Subsequent evaluation in chimpanzees indicated that cp45 appeared to be satisfactorily attenuated while still able to induce a high level of protection against wild-type virus challenge (61) . Later preliminary clinical evaluation of cp45 in seronegative human infants and small children suggested that this candidate vaccine strain is suitably infectious and attenuated, as well as being moderately immunogenic (61) .

The cp45 strain has been grown in both fetal rhesus lung (FRhL) and Vero cells as follows: The PIV- 3 cp45 virus grown in FRhL cells was prepared by inoculating confluent FRhL cell monolayers in tissue culture flasks at an MOI 0.1-1.0. The infected cell cultures were fed with EMEM medium and incubated at 32°C. About seven days later, when maximal cytopathic effects (synctyia) were observed, the virus was harvested by subjecting the cultures to one freeze-thaw cycle, pooling the fluids and then storing the virus at -70 °C.

The PIV-3 cp45 virus grown in Vero cells was prepared by inoculating with virus a bioreactor culture of confluent monolayers of Vero cells on microcarrier beads which was continuously stirred. The infected bioreactor culture was maintained at 30°C. The virus was harvested 4-5 days later when syncytial CPE was observed. The culture fluid containing the virus was stored at -70 °C.

The nucleotide sequences (in positive strand, antigenomic, message sense) of the HPIV-3 JS wild- type strain (89) and the cp45 vaccine strain grown in FRhL and Vero cells, as well as the deduced amino acid sequences of the RNA polymerase (L protein) of these HPIV-3 viruses, are set forth as follows with reference to the appropriate SEQ ID NOS. contained herein:

Virus Nucleotide Sequence L Protein Sequence

Wild-Type JS SEQ ID NO: 17 SEQ ID NO: 18

Vaccine FRhL cp45 SEQ ID NO: 19 SEQ ID NO: 20

Vero cp45 SEQ ID NO: 21 SEQ ID NO: 22

Each PIV-3 virus genome listed above is 15,462 nucleotides in length. Translation of the L gene starts with the codon at nucleotides 8646-8648; the translation stop codon is at nucleotides 15345- 15347. The translated L protein is 2,233 amino acids long.

As detailed in Example 2 and Table 6 therein below, based upon the differences between the wild-type JS strain and the FRhL-grown cp 45 mutant vaccine strain, the key attenuating mutations for the HPIV-3 3' genomic promoter region are nucleotide 23 (T — > C) , nucleotide 24 (C — > T) , nucleotide 28 (G — > T) and nucleotide 45 (T — A) (in antigenomic, message sense). As also detailed in Example 2 and Table 6 therein below, key attenuating sites for the L protein of HPIV- 3 include the following: amino acid residues 942 (tyrosine —> histidine) , 992 (leucine — phenylalanine) and 1558 (threonine —> isoleucine) .

In addition, the Vero-grown cp45 mutant vaccine strain contains an additional mutation resulting from a coding change in the L gene at amino acid residue 1292 (leucine - phenylalanine) . It is understood that the nucleotide changes responsible for these amino acid changes are not limited to those set forth in Example 2 below; all changes in nucleotides which result in codons which are translated into these amino acids are within the scope of this invention.

Human respiratory syncytial virus (RSV) is yet another nonsegmented, negative-sense, single stranded enveloped RNA virus. RSV belongs to the Subfamily Pneumovirinae and the genus Pneumovirus (see Table 1) .

Two major subgroups of human RSV, designated A and B, have been identified based on reactivities of the F and G surface glycoproteins with monoclonal antibodies (62) . More recently, the A and B lineages of RSV strains have been confirmed by sequence analysis (63,64). Bovine, ovine, and caprine strains of this virus have also been isolated. The host specificity of the virus is most clearly associated with the G attachment protein, which is highly divergent between the human and the bovine/ovine strains (65,66), and may be influenced, at least in part, by receptor binding.

RSV is the primary cause of serious viral pneumonia and bronchiolitis in infants and young children. Serious disease, i.e., lower respiratory tract disease (LRD) , is most prevalent in infants less than six months of age. It most commonly occurs in the nonimmune infant's first exposure to RSV. RSV additionally is associated with asthma and hyperreactive airways and it is a significant cause of mortality in "high risk" children with bronchopulmonary dysplasia and congenital heart disease (CHD) . It is also one of the common viral respiratory infections predisposing to otitis media in children. In adults, RSV generally presents as uncomplicated upper respiratory illness; however, in the elderly it rivals influenza as a predisposing factor in the development of serious LRD, particularly bacterial bronchitis and pneumonia. Disease is always confined to the respiratory tract, except in the severely immunocompromised, where dissemination to other organs can occur. Virus is spread to others by fomites contaminated with virus-containing respiratory secretions, and infection initiates through the nasal, oral, or conjunctival mucosa.

RSV disease is seasonal and virus is usually isolated only in the winter months, e.g., from November to April in northern latitudes. The virus is ubiquitous, and over 90% of children have been infected at least once by 2 years of age. Multiple strains cocirculate. There is no direct evidence of antigenic drift (such as that seen with influenza A viruses) , but sequence studies demonstrating accumulation of amino acid changes in the hypervariable regions of the G protein and SH proteins suggest that immune pressure may drive virus evolution.

In mouse and cotton rat models, both the F and G proteins of RSV elicit neutralizing antibodies and immunization with these proteins alone provides longterm protection against reinfection (67,68).

In humans, complete immunity to RSV does not develop and reinfections occur throughout life (69,70); however, there is evidence that immune factors will protect against severe disease. A decrease in severity of disease is associated with two or more prior infections and there is evidence that children infected with one of the two major RSV subgroups may be somewhat protected against reinfection with the homologous subgroup (71) , observations which suggest that a live attenuated virus vaccine may provide protection sufficient to prevent serious morbidity and mortality. Infection with RSV elicits both antibody and cell mediated immunity. Serum neutralizing antibody to the F and G proteins has been associated, in some studies, with protection from LRD, although reduction in upper respiratory disease (URD) has not been demonstrated. High levels of serum antibody in infants is associated with protection against LRD, and adminstration of intravenous immunoglobulin with high RSV neutralizing antibody titers has been shown to protect against severe disease in high risk children (70,72,73). The role of local immunity, and nasal antibody in particular, is being investigated. The RSV virion consists of a ribonucleoprotein core contained within a lipoprotein envelope. The virions of pneumoviruses are similar in size and shape to those of all other paramyxoviruses. When visualized by negative staining and electron microscopy, virions are irregular in shape and range in diameter from 150-300 nm (74) . The nucleocapsid of this virus is a symmetrical helix similar to that of other paramyxoviruses, except that the helical diameter is 12-15 nm rather than 18nm. The envelope consists of a lipid bilayer that is derived from the host membrane and contains virally coded transmembrane surface glycoproteins . The viral glycoproteins mediate attachment and penetration and are organized separately into virion spikes. All members of paramyxovirus subfamily have hemagglutinating activity, but this function is not a defining feature for pneumoviruses, being absent in RSV but present in PVM (75) . Neuraminidase activity is present in members of the genera Paramyxovirus, Rubulavirus, and is absent in Morbillivirus and Pneumovirus of mice (PVM) (75) .

RSV possesses two subgroups, designated A and B. The wild- type RSV (strain 2B) genome is a single strand of negative-sense RNA of 15,218 nucleotides (SEQ ID NO: 23) that are transcribed into ten major subgenomic mRNAs. Each of the ten mRNAs encodes a major polypeptide chain: Three are transmembrane surface proteins (G, F and SH) ; three are the proteins associated with genomic RNA to form the viral nucleocapsid (N, P and L) ; two are nonstructural proteins (NSl and NS2) which accumulate in the infected cells but are also present in the virion in trace amounts and may play a role in regulating transcription and replication; one is the nonglycosylated virion matrix protein (M) ; and the last is M2, another nonglycosylated protein recently shown to be an RSV- specified transcription elongation factor (see Figure 3) . These ten viral proteins account for nearly all of the viral coding capacity.

The viral genome is encapsidated with the major nucleocapsid protein (N) , and is associated with the phosphoprotein (P) , and the large (L) polymerase protein. These three proteins have been shown to be necessary and sufficient for directing RNA replication of cDNA encoded RSV minigenomes (76) . Further studies have shown that for transcription to proceed with full processing, the M2 protein (ORF 1) is required (74) . When the M2 protein is missing, truncated transcripts predominate, and rescue of the full length genome does not occur (74) . Both the M (matrix protein) and the M2 proteins are internal virion-associated proteins that are not present in the nucleocapsid structure. By analogy with other nonsegmented negative-stranded RNA viruses, the M protein is thought to render the nucleocapsid transcriptionally inactive before packaging and to mediate its association with the viral envelope. The NSl and NS2 proteins have only been detected in very small amounts in purified virions, and at this time are considered non-structural . Their functions are uncertain, though they may be regulators of transcription and replication. Three transmembrane surface glycoproteins are present in virions: G, F, and SH. G and F (fusion) are envelope glycoproteins that are known to mediate attachment and penetration of the virus into the host cell. In addition, these glycoproteins represent major independent immunogens (77) . The function of the SH protein is unknown, although a recent report has implicated its involvement in the fusion function of the virus (78) . The genomes of two wild-type RSV subgroup B strains (2B and 18537) have now been sequenced in their entirety (see SEQ ID NOS:23 and 25, discussed below) . Genomic RNA is neither capped nor polyadenylated (79) . In both the virion and intracellularly, genomic RNA is tightly associated with the N protein. The 3* end of the genomic RNA consists of a 44-nucleotide extragenic leader region that is presumed to contain the major viral promoter (Fig. 3) . The 3' genomic promoter region is followed by ten viral genes in the order 3 ' -NS1-NS2-N-P-M-SH-G-F-M2-L-5 ' (Fig. 3). The L gene is followed by a 145-149 nucleotide extragenic trailer region (see Figure 3) . Each gene begins with a conserved nine-nucleotide gene start signal 3 ' -GGGGCAAAU (except for the ten-nucleotide gene start signal of the L gene, which is 3 • -GGGACAAAAU; differences underlined) . For each gene, transcription begins at the first nucleotide of the signal. Each gene terminates with a semi-conserved 12-14 nucleotide gene end (3' -A G U/G U/A ANNN U/A A₃.₅) (where N can be any of the four bases) that directs transcription termination and polyadenylation (Fig. 3) . The first nine genes are non-overlapping and are separated by intergenic regions that range in size from 3 to 56 nucleotides for RSV B strains (Fig. 3) . The intergenic regions do not contain any conserved motifs or any obvious features of secondary structure and have been shown to have no influence on the preceding and succeeding gene expression in a minreplicon system (Fig. 3) . The last two RSV genes overlap by 68 nucleotides (Fig. 3) . The gene-start signal of the L gene is located inside of, rather than after, the M2 gene. This 68 nucleotide overlap sequence encodes the last 68 nucleotides of the M2 mRNA (exclusive of the Poly-A tail) , as well as the first 68 nucleotides of the L mRNA.

Ten different species of subgenomic polyadenylated mRNAs and a number of polycistronic polyadenylated read-through transcripts are the products of genomic transcription (74) . Transcriptional mapping studies using UV light mediated genomic inactivation showed that RSV genes are transcribed in their 3 ' to 5 ' order from a single promoter near the 3' end (80). Thus, RSV synthesis appears to follow the single entry, sequential transcription model proposed for all Mononegavirales (16,81). According to this model, the polymerase (L) contacts genomic RNA in the nucleocapsid form at the 3 ' genomic promoter region and begins transcription at the first nucleotide. RSV mRNAs are co-linear copies of the genes, with no evidence of mRNA editing or splicing.

Sequence analysis of intracellular RSV mRNAs showed that synthesis of each transcript begins at the first nucleotide of the gene start signal (74). The 5* end of the mRNAs are capped with the structure m7G(5 • )ppp(5 ' )Gp (where the underlined G is the first template nucleotide of the mRNA) and the mRNAs are polyadenylated at their 3' ends (82) . Both of these modifications are thought to be made co- transcriptionally by the viral polymerase. Three regions of the RSV 3 ' genomic promoter have been found to be important as cis acting elements (83) . These regions are the first ten nucleotides (presumably acting as a promoter) , nucleotides 21-25, and the gene start signal located at nucleotides 45-53 (83) . Unlike other Paramyxovirinae, such as measles, Sendai and PIV- 3, the remainder of the leader and non-coding region of NSl gene of RSV was found to be highly tolerant of insertions, deletions and substitutions (83) . Additionally, by saturation mutagenesis

(wherein each base is replaced independently by each of the other three bases and compared for translation and replication efficiencies) within the first 12 nucleotides of the 3 ' genomic promoter region, a U- tract located at nucleotides 6-10 was shown to be highly inhibitory to substitutions (83) . In contrast, the first five nucleotides were relatively tolerant of a number of substitutions and two of them at position four were up-regulatory mutations, resulting in a four- to 20-fold increase in RSV-CAT RNA replication and transcription. Using a bi-cistronic minireplicon system, gene-start and gene-end motifs were shown to be signals for mRNA synthesis and appear to be self contained and largely independent of the nature of adjoining sequence (84) .

The L gene start signal lies 68 nucleotides upstream of the M2 gene-end signal, resulting in gene overlap (Fig. 3) (74) . The presence of the M2 gene-end signal within the L gene results in a high frequency of premature termination of L gene transcripts. Full length L mRNA is much less abundant and is made when the polymerase fails to recognize the M2 gene-end motif. This results in much lower transcription of L mRNA. The gene overlap seems incompatible with a model of linear sequential transcription. It is not known whether the polymerase that exits the M2 gene jumps backward to the L gene-start signal or whether there is a second, internal promoter for L gene transcription (74) . It is also possible that the L gene is accessible by a small fraction of polymerases that fail to start transcription at the M2 gene-start signal and slide down the M2 gene to the L gene-start signal. The relative abundance of each RSV mRNA decreases with the distance of its gene from the promoter, presumably due to polymerase fall-off during sequential transcription (80) . Gene overlap is a second mechanism that reduces the synthesis of full length L mRNA. Also, certain mRNAs have features that might reduce the efficiency of translation. The initiation codon for SH mRNA is in a suboptimal Kozak sequence context, while the G ORF begins at the second methionyl codon in the mRNA.

RSV RNA replication is thought (74) to follow the model proposed from studies with vesicular stomatitis virus and Sendai virus (16,81). This involves a switch from the stop-start mode of mRNA synthesis to an antiterminator read- through mode. This results in synthesis of positive sense replication- intermediate (Rl) RNA that is an exact complementary copy of genomic RNA. This serves in turn as the template for the synthesis of progeny genomes. The mechanism involved in the switch to the antiterminator mode is proposed to involve cotranscriptional encapsidation of the nascent RNA by N protein (16,81). RNA replication in RSV like other nonsegmented negative-strand RNA viruses is dependent on ongoing protein synthesis (85) . Predicted Rl RNA has been detected for the standard virus as well as RSV-CAT minigenome (74,85). Rl RNA was 10-20 fold less abundant intracellularly than was the progeny genome both for the standard and the minigenome system. The nucleotide sequences (in positive strand, antigenomic, message sense) of various wild- type, vaccine and revertant RSV strains, as well as the deduced amino acid sequences of the RNA polymerase (L protein) of these RSV viruses, are set forth as follows with reference to the appropriate SEQ ID NOS. contained herein: L Protein Sequence

SEQ ID NO: 24 SEQ ID NO: 26

SEQ ID NO: 28 SEQ ID NO: 30

2B33F TS(+) SEQ ID NO: 31 SEQ ID NO: 32 2B20L TS(+) SEQ ID NO: 33 SEQ ID NO: 34

Each RSV virus genome encodes an L protein that is 2,166 amino acids long. Genome length and other nucleotide information is as follows:

As detailed in Example 3 (especially Tables 7 and 8) below, the key attenuating mutations for the RSV subgroup B 3 ' genomic promoter region are nucleotide 4 (C - G) , and the insertion of an additional A in the stretch of A's at nucleotides 6-11 (in antigenomic message sense) . As also detailed in Example 3 below, the key potentially attenuating sites for the L protein of RSV are as follows: amino acid residues 353 (arginine —> lysine), 451 (lysine —> arginine), 1229 (aspartic acid -» asparagine) , 2029 (threonine — isoleucine) and 2050 (asparagine — > aspartic acid) . It is understood that the nucleotide changes responsible for these amino acid changes. are not limited to those set forth in Example 3 below; all changes in nucleotides which result in codons which are translated into these amino acids are within the scope of this invention.

The attenuated viruses of this invention exhibit a substantial reduction of virulence compared to wild- type viruses which infect human and animal hosts. The extent of attenuation is such that symptoms of infection will not arise in most immunized individuals, but the virus will retain sufficient replication competence to be infectious in and elicit the desired immune response profile in the vaccinee.

The attenuated viruses of this invention may be used to formulate a vaccine. To do so, the attenuated virus is adjusted to an appropriate concentration and formulated with any suitable vaccine adjuvant, diluent or carrier. Physiologically acceptable media may be used as carriers. These include, but are not limited to: an appropriate isotonic medium, phosphate buffered saline and the like. Suitable adjuvants include, but are not limited to MPL™ (3-O-deacylated monophosphoryl lipid A; RIBI ImmunoChem Research, Inc., Hamilton, MT) and IL-12 (Genetics Institute, Cambridge, MA) .

In one embodiment of this invention, the formulation including the attenuated virus is intended for use as a vaccine. The attenuated virus may be mixed with cryoprotective additives or stabilizers such as proteins (e.g., albumin, gelatin), sugars (e.g., sucrose, lactose, sorbitol) , amino acids (e.g., sodium glutamate) , saline, or other protective agents. This mixture is maintained in a liquid state, or is then dessicated or lyophilized for transport and storage and mixed with water immediately prior to administration.

Formulations comprising the attenuated viruses of this invention are useful to immunize a human or animal subject to induce protection against infection by the wild-type counterpart of the attenuated virus. Thus, this invention further provides a method of immunizing a subject to induce protection against infection by an RNA virus of the Order Mononegavirales by administering to the subject an effective immunizing amount of a vaccine formulation incorporating an attenuated version of that virus as described hereinabove.

A sufficient amount of the vaccine in an appropriate number of doses must be administered to the subject to elicit an immune response. Persons skilled in the art will readily be able to determine such amounts and dosages. Administration may be by any conventional effective form, such as intranasally, parenterally, orally, or topically applied to any mucosal surface such as intranasal, oral, eye, vaginal or rectal surface, such as by an aerosol spray. The preferred means of administration is by intranasal administration. In another embodiment of this invention, an isolated nucleic acid molecule having the complete viral nucleotide sequence of either the wild- type viruses or vaccine viruses described herein is used to generate oligonucleotide probes (from either positive strand antigenomic message sense or negative strand complementary genomic sense) and to express peptides (from positive strand antigenomic message sense only) , which are used to detect the presence of those wild- type virus and/or vaccine strains in samples of body fluids and tissues. The nucleotide sequences are used to design highly specific and sensitive diagnostic tests to detect the presence of the virus in a sample. Polymerase chain reaction (PCR) primers are synthesized with sequences based on the viral wild- type or vaccine sequences described herein. The test sample is subjected to reverse transcription of RNA, followed by PCR amplification of selected cDNA regions corresponding to the nucleotide sequence described herein which have nucleotides which are distinct for a defined strain of virus. Amplified PCR products are identified on gels and their specificity confirmed by hybridization with specific nucleotide probes.

ELISA tests are used to detect the presence of antigens of the wild-type or vaccine viral strains. Peptides are designed and selected to contain one or more distinct residues based on the wild- type or vaccine sequences described herein. These peptides are then coupled to a hapten (e.g., keyhole limpet hemocyanin (KLH) and used to immunize animals (e.g., rabbits) for the production of monospecific polyclonal antibody. A selection of these polyclonal antibodies, or a combination of polyclonal and monoclonal antibodies can then be used in a "capture ELISA" to detect antigens produced by those viruses. Samples of the Moraten measles virus vaccine strain were deposited by Applicants with the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852, U.S.A., under the provisions of the Budapest Treaty for the Deposit of Microorganisms for the Purposes of Patent Procedures ("Budapest Treaty") and have been assigned ATCC accession number VR2587. Samples of the HPIV-3 virus Vero-grown cp45 vaccine strain were deposited by Applicants with the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852,

U.S.A., under the provisions of the Budapest Treaty and have been assigned ATCC accession number VR2588. Samples of the 2B wild-type RSV virus were deposited by Applicants with the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852,

U.S.A., under the provisions of the Budapest Treaty and have been assigned ATCC accession number VR2586.

Given these three deposited strains and the sequence information for these and other strains provided herein, one can use site-directed mutagenesis and rescue techniques described above to introduce mutations (or restore a wild- type genotype) of all the strains described herein, as well as taking these strains and making additional mutations from the panel of mutations set forth in Tables 3, 4 and 6-8 below.

In order that this invention may be better understood, the following examples are set forth. The examples are for the purpose of illustration only and are not to be construed as limiting the scope of the invention.

Examples

Standard molecular biology techniques are utilized according to the protocols described in Sambrook et al . (86). Example 1 Measles

Moraten MV vaccine virus was grown once, directly from the Attenuvax™ vaccine vial (Lot #0716B) , the Schwarz vaccine virus was grown once (Lot 96G04/M179 G41D) , while the Zagreb and Rubeovax™ vaccine viruses were each grown twice in the Vero cells before RNAs were made for sequence analysis. MV wildtype isolate Montefiore (56) was passed 5-6 times in Vero cells before extraction of RNA materials and similarly, MV wildtype isolates 1977, 1983 (14) were grown 5-7 times before extracting materials for analysis. Edmonston wild-type isolate received from Dr. J. Beeler (CBER) (see Fig. 1) was the original

Edmonston isolate already passaged seven times in human kidney cells and three times in Vero cells before receipt and further passaged once in Vero cells before using for sequence analysis. RNA was prepared by infecting Vero cells at a multiplicity of infection (m.o.i.) of 0.1 to 1.0 and allowed to reach maximum cytopathology before being harvested. Total RNA from measles virus-infected cells was extracted using Trizol™ reagent (Gibco-BRL) . The total RNA isolated from Vero cell passage material was amplified by the Reverse Transcriptase-PCR (Perkin-Elmer/Cetus) procedure using measles (Edmonston B strain (19)) specific primer pairs spanning the 3' and 5 ' promoter regions and the L gene of the viral genome . Table 2 presents these primer sequences . The primers of SEQ ID NOS: 35-54, 74, 77 and 78 are in antigenomic message sense . The primers of SEQ ID NOS: 55-73, 75, 76 and 79 are in genomic negative-sense. Table 2

Primers for PCR and Sequencing MV L Genes and Genomic Termini

₉₀₄₇CATATCACTCACTCTGGGATGGAG₉₀₇₀ (SEQ ID NO:35) ₉₃₇₁TCAGAACATCAAGCACCGCC₉₃₉₀ (SEQ ID NO: 36) ₉₇₄₁ACAGTCAAGACTGAGATGAG₉₇₆₀ (SEQ ID NO: 37) ₀₀₀₁AAGAGTCAGATACATGTGGA₁₀₀₂₀ (SEQ ID NO: 38) ₀₃₅₁ACATGAATCAGCCTAAAGTC₁₀₃₇₀ (SEQ ID NO: 39) ₀₆₇₄CCGAAAGAGTTCCTGCGTTACGACC₁₀₆₉₈ (SEQ ID NO: 40) _10B3CAGTCCACACAAGTACCAGG₁₁₁₀₂ (SEQ ID NO: 41) ₁₄₆₁GTCAGAAGCTGTGGACCATC₁₁₄₈₀ (SEQ ID NO:42) _lβ41AATATTGCTACAACAATGGC_118β0 (SEQ ID NO: 43) ₂₁₉₆ACTCTTCATTCCTAGACTGG₁₂₂₁₅ (SEQ ID NO: 44) ₂₅₄₂GTCCAATTATGACTATGAAC₁₂₅₆₁ (SEQ ID NO: 45) _2β91AGAACAGACATGAAGCTTGC₁₂₉₁₀ (SEQ ID NO: 46) ₃₂₃₂ CCAACAAGGAATGCTTCTAG₁₃₂₅. (SEQ ID NO:47) ₃₅₅₁ACAGCACTATCTATGATTGACCTGG_{13 S75} (SEQ ID NO:48) ₃₉₃₀GCAACATGGTTTACACATGC₁₃₉₄₉ (SEQ ID NO: 49) ₄₂₈₀AGATTGAGAGTTGATCCAGG₁₄₂₉₉ (SEQ ID NO:50) ₄₆₂₉AGGAGATACTTAAACTAAGC_1464β (SEQ ID NO:51) ₄₉₈₁TAAGCTTATGCCTTTCAGCG₁₅₀₀₀ (SEQ ID NO:52) ₅₃₃₇TTAACGGACCTAAGCTGTGC₁₅₃₅₆ (SEQ ID NO: 53) _S671GAAACAGATTATTATGACGG₁₅₆₉₀ (SEQ ID NO:54)

₉₂₉₀CGGGCTATCTAGGTGAACTTCAGG₉₂₆₇ (SEQ ID NO:55)

₉₅₀₀ATTTGGATATGGAATATGAG_{94 B1} (SEQ ID NO: 56)

₉₈₄₀ACTCAACTGAACTACCAGTG_9β21 (SEQ ID NO:57)

₁₀₁₈₁AAGAACATCATGTATTTCAG₁₀₁₆₂ (SEQ ID NO: 58)

₁₀₅₄₉TTATCAACGCACTGCTCATG₁₀₅₃₀ (SEQ ID NO:59)

₁₀₉₁₉ATTTTCAGCAATCACTTGGCATGCC₁₀₈₉₅ (SEQ ID NO: 60) ιi₂₈₀GCCTCTGTGCAAACAAGCTG₁₁₂₆₁ (SEQ ID NO: 61)

₁₁₆₃₈TCTCTAGTTACTCTAGCAGC₁₁₆₁₉ (SEQ ID NO: 62) ₁₂₀₁₀AGGTCGTTGTTTGTGAGGAG₁₁₉₉₁ (SEQ ID NO: 63) ₁₂₃₆₁TCGTCCTCTTCTTTACTGTC₁₂₃₄₂ (SEQ ID NO: 64) ₁₂₆₈₉CCGTCCTCGAGCTAGCCTCG₁₂₆₇₀ (SEQ ID NO: 65)

₁₃₀₅₂CTCCTCCAGGCTCACATTGG₁₃₀₃₃ (SEQ ID NO: 66)

₁₃₄₂₀GGGTTGGTACATAGCTCTGC₁₃₄₀₁ (SEQ ID NO: 67)

₁₃₇₆₇CACCCATCTGATATTTCCCTGATGG₁₃₇₄₃ (SEQ ID NO: 68)

₁₄₀₉₉TGGTTGACAGTACAAATCTG₁₄₀₈₀ (SEQ ID NO: 69)

₁₄₄₆₀CTGAAATGGGAAGATTGTGC₁₄₄₄₁ (SEQ ID NO: 70)

₁₄₈₂₀AGCAATCTACACTGCCTACC_14β01 (SEQ ID NO:71)

₁₅₁₈₀TCACAGATGATTCAATTATC_1S161 (SEQ ID NO: 72)

₁₅₅₃₀GATCCTAGATATAAGTTCTC₁₅₅₁₁ (SEQ ID NO: 73)

iACCAAACAAAGTTGGGTAAGG,_! (SEQ ID NO: 74)

GGGGGATCC₁₀₀ATCCCTAATCCTGCTCTTGTCCC_7β (SEQ ID NO: 75)

₂₀₀GATTCCTCTGATGGCTCCAC_lβl (SEQ ID NO: 76)

_1S721TAACAGTCAAGGAGACCAAAG₁₅₇₄₁ (SEQ ID NO: 77) GGGAAGCTT₁₅₈₀₁AACCCTAATCCTGCCCTAGGTGG₁₅₈₂₃ (SEQ ID NO: 78)

₁₅₈₉₄ACCAGACAAAGCTGGGAATAGA_15B73 (SEQ ID NO: 79)

Overlapping PCR fragments of the complete viral genome were directly sequenced without cloning to achieve the consensus sequence, by the dideoxy terminator cycle sequencing method using both strands (ABI PRISM 377 sequencer and ABI PRISM sequencing Kit) . To determine the sequence at the absolute termini, a ligation procedure described previously was used (55) . To test this hypothesis, the nucleotide sequences were determined for the non-protein coding regulatory regions and the L gene of the progenitor Edmonston wild-type MV isolate, for the available vaccine strains derived from this isolate, as well as for other wild-type strains. Nucleotide (in antigenomic, message sense) and amino acid differences were then compared and aligned as set forth in Tables 3-5 (differences are in italics) : Table 3

Differences in MV 3' Genomic Promoter Region

Nucleotide Sequence

Table 4 Differences in MV L Nucleotides and Amino Acids Between Edmonston Wild-Type and Vaccine Strains

331 1409 1624 1649 1717 1887 1936 2074 2114

Edmonston w-t ATT GCA ACC AGG GAT AAC CAT CAA AGA Mutation ACT ACA GCC ATG GCT GAC TAT CGA AAA

Table 5 Differences in MV L Nucleotides and Amino Acids Between Wild-Type Strains

D n

O en

-

Table 5 (continued)

Differences in MV L Nucleotides and Amino Acids

Between Wild-Type Strains

0c)

CD cn

m cn x m m

ι

Example 2 PIV- 3

A comparison of sequences (in antigenomic message sense) of the parental wild-type JS strain of PIV-3 virus and the FRhL-grown and Vero-grown forms of the cp45 mutant are set forth in Table 6. Where a codon change does not result in an amino acid change, Table 6 states "none", followed by the name of the unchanged amino acid.

Table 6 Sequence Comparison of Vero- and FRhL-grown cp45 & JS strains

Sequence analysis of the parental wild- type JS strain of PIV-3 virus and the FRhL-grown cp45 mutant showed that the latter contained 20 nucleotide changes. Four changes were in the noncoding 3 '-leader region at nucleotide positions 23 (T - C) , 24 (C — > T) , 28 (G - T) and 45 (T — > A) (in antigenomic, message sense) . When considered in the genomic, negative sense, the change at position 28 from the smaller pyrimidine ("C") to the larger purine ("A") may change the size of the region flanked by the conserved regions of the 3 ' genomic promoter region, resulting in an altered spatial presentation of the cis-acting signals to the polymerase.

Nine changes were coding changes in the NP, M, F, HN and L genes. The other seven changes were non-coding or silent changes in the NP, P, F, HN and L genes or the NP untranslated region (UTR) . The cp45 mutant has been demonstrated to have poor transcription activity at non-permissive temperatures due to its ts phenotype (87) . This ts phenotype has now been mapped to the viral L gene (88) . Because the cp45 virus has been shown to function normally with regard to mutations in the HN and F glycoproteins (87) , this supports the implication that mutations in the 3 ' - leader and L gene contributed to the attenuating phenotype of this virus.

Thus, the four 3* leader specific changes in FRhL-grown cp45 and the three coding changes in the L gene at amino acid positions 942 (Tyr —►His), 992 (Leu → Phe) and 1558 (Thr →lle) contributed significantly to the attenuation phenotype of the candidate cp45 vaccine strain.

Furthermore, the Vero-grown cp45 mutant vaccine strain contains an additional mutation resulting from a coding change in the L gene (marked with an asterisk in Table 6) at amino acid residue 1292 (leucine -» phenylalanine) .

The first two amino acid changes in the L protein (at positions 942 and 992) map to one of the highly conserved areas among all Paramyxovirus L genes. The fourth amino acid change (at position 1558) maps to the area joining two conserved blocks corresponding to the change at amino acid 1717 in the MV vaccine strains. The published literature (89) sets forth only

18 changes between the antigenomic message sense sequences of the JS and FRhL-grown cp45 strains. Sixteen of these changes were found by applicants.

The published literature did not report four changes found by applicants: in the 3' leader at nucleotide 45 (T — A) , in the NP UTR at nucleotide 62 (A — T) , or the changes in amino acids in the NP protein resulting from the changes at nucleotide 397 (T —> C) , leading to the amino acid change (Val —>Ala) and nucleotide 1275 (T — G) , leading to the amino acid change (Ser —> Ala) (nucleotide changes in antigenomic, message sense) . Nor did the published literature report the additional potentially attenuating mutation in the L protein found by applicants in the Vero-grown cp45 strain resulting from the change at nucleotide 12521 (A —> T) , leading to the change in amino acid 1292 (Leu → Phe) . Example 3 RSV Subgroup B

The temperature-sensitive (ts) phenotype is strongly associated with attenuation in vivo,- in addition, some non-ts mutations may also be attenuating. Identification of ts and non-ts attenuating mutations was achieved by sequence analysis and evaluation of ts, cold-adapted (ca) , and in vivo growth phenotypes of RSV mutants and revertants.

The genomes of the following five RSV 2B strains have now been completely sequenced: 2B parent, 2B33F, one revertant designated 2B33F TS(+), 2B20L and one revertant designated 2B20L TS(+). The 2B33F and 2B20L strains are ts and ca and are described in U.S. Serial No. 08/059,444 (90), which is hereby incorporated by reference. After identifying regions where mutations in 2B33F and 2B20L are located, nine additional isolates of 2B33F "revertants" obtained following in vi tro passaging at 39°C and in vivo passaging in African Green Monkeys or chimpanzees, and nine additional isolates of 2B20L "revertants" obtained following in vi tro passaging at 39°C have been sequenced in those regions. The ts, ca , and attenuation phenotypes of many of these revertants have now been characterized and assessed. Correlations between phenotype ts, vaccine attenuation and sequence changes have been identified.

A summary of results is presented in Tables 7-12. Table 7 Sequence comparison between RSV 2B and 2B33F strains

For 2B33F and 2B33F TS(+), nucl. pos. numbers are one larger than for 2B for M, SH & L genes At pos. 9853, the Lys-Arg change has reverted back to Lys in the 2B33F TS(+) strain Table 8 Sequence comparison between RSV 2B and 2B20L strains

For 2B20L and 2B20L TS(-t-), nucl. pos. numbers are one larger than for 2B for L gene

* Mutation is common in 2B33F and 2B20L strains ** At pos. 14650, the mutation suppresses the ts phenotype in 2B20L TS(+) revertant

Table 9 RSV 2B, ts and Revertant Strains

CO

C CD

H

C H m cn x m m

3 c r m- ro

Of

Table 9 (continued) RSV 2B, ts and Revertant Strains

O n

Table 9 (continued) RSV 2B, ts and Revertant Strains

* In Vivo growth measured in log₁₀ mean virus titer (# infected/# total)

ND = not done WT = wild- type plaque size sp = small plaque size int = intermediate plaque size

Table 10 2B33F Revertants

t These 2B33F revertant base nos. are one larger than for 2B for M,

SH and L genes * bases 4330,4410,4421,4443,4455,4485,4498,4506,4526,4527,4543,

4562,4576,4599 S = same base as 2B33F

2B s reversion to 2B base or complete reversion in phenotype r = moderate reversion in phenotype (r) = slight reversion in phenotype ND = not done Table 11 2B20L Revertants

t These 2B20L revertant base nos. are one larger than for 2B for L genes S = same base as 2B20L 2B = reversion to 2B base r = moderate reversion in phenotype * = base change, different from 2B or 2B20L

ND not done

Table 12 RSV 2B, ts and Revertant Strains: Phenotype Summary

Table 12 (continued)

RSV 2B, ts and Revertant Strains: Phenotype Summary

ND = not done

- = wild-type phenotype, i.e., not temperature sensitive, not cold adapted, not attenuated + to ++++ = increasing levels of temperature sensitivity, cold- adaptation or attenuation

Several significant observations can be drawn from these data:

a. As shown in Tables 7 (for 2B33F) and 8 (for 2B20L) , there are relatively few sequence changes identified in the two mutant strains: RSV 2B33F differs from parental RSV 2B by two changes at the 3 ' genomic promoter region, two changes at the non-coding 5' -end of the gene, and four coding changes plus one non-coding (poly (A) motif) change in the RNA dependent RNA polymerase coding L gene. In addition, 14 changes mapped to the SH gene alone. RSV 2B20L differs from its RSV 2B parent only at seven nucleotide positions, of which three are common with 2B33F virus, including two changes at the 3' genomic promoter and one coding change in the L gene. Two additional unique changes of 2B20L virus mapped to the coding region of the L gene. Potentially attenuating mutations at the non-coding 3' genomic promoter region and the RNA dependent RNA polymerase gene have been identified.

b. Two ts mutations can be identified in the L gene of the attenuated virus strains 2B33F and 2B20L:

(i) In 2B33F, a mutation at nucleotide position 9853 (A —> G) leading to a coding change in L protein at amino acid 451 (Lys —> Arg) is clearly associated with the ts and attenuation phenotypes. Reversion at this site alone in the 2B33F TS( +) 5a strain is responsible for complete restoration of growth at 39°C (Table 9) and partial reversion in attenuation in animals. This association with the ts and attenuation phenotypes was also supported by partial sequence analyses of six additional "full TS revertants" (designated 4a, 3b, pp2 , 3A, 5a, 5A) isolated from cell culture and from chimps, in which only the nucleotide 9853 mutation reverted (Tables 10-12) (note that one AGM (African Green Monkey) isolate which reverted at 9853 only partially reverted in ts phenotype) . This amino acid 451 mutation (Lys —> Arg) is amenable to stabilization in cDNA infectious clone constructs, by inserting a second mutation to stabilize the codon, thereby lessening the likelihood that it will revert back to Lys .

(ii) In 2B20L, a mutation at base 14,649 (A -> G) leading to a coding change in the L protein (amino acid position 2,050, Asn —>Asp) appears to be associated with the ts and attenuation phenotypes . This aspartic acid at the amino acid 2050 invariably reverts back (Asp —> Asn) in TS(+) revertants or changes to a different amino acid (Asp — > Val) by nucleotide substitution at position 14,650 (A -> T) (Tables 8, 11) . The above observation is based on complete sequence analysis on the TS(+) revertant Rl and partial sequence of several additional TS(+) revertants (R2, R4A, R7A, R8A) at selected regions (Table 11) . An additional mutation is seen in the Rl revertant at nucleotide postion 13,347 (amino acid 1616, Asn —» Asp) associated with the above reversion. However, the effect of this mutation on the ts phenotype is not known; the L gene of other revertants has not been sequenced completely.

c. Three base changes are common to 2B33F and 2B20L strains of virus:

(i) A change at position 14,587 (C → T) with a corresponding change (Thr — > lie) at amino acid 2029 is present in both 2B33F and 2B20L (Tables 7,8). This nucleotide "T" substitution was found to be present in 10% of the population of the progenitor RSV2B strain and may have been preferred during the attenuation process. No wildtype base "C" was found in the 2B33F and 2B20L virus.

(ii) Two mutations are seen in the 2B33F and 2B20L 3' genomic promoter region: nucleotide 4 (C — > G) and the insertion of an extra A in the stretch of A's at positions 6-11 (in antigenomic, message sense) . When the sequences of selected TS(+) revertants were analyzed, these mutations were seen to have been retained in the 2B33F TS(+)5a (Table 7) and the 2B20L TS(+)R1 (Table 8) revertants. These non-coding, cis- acting mutations remained associated with partial viral attenuation.

Expression using the minireplicon RSV-CAT system for the analysis of these cis-acting changes has shown the 3 * genomic promoter nucleotide 4 (C —» G) change to be an upregulation of transcription/replication in this in vi tro system when the 2B progenitor virus or either of the 2B33F or 2B33F TS(+) provided helper L gene functions (the N, P and M2 genes are identical in these viruses) .

Complementation analysis of the 2B33F 3' genomic promoter and the helper functions provided by the progenitor RSV2B virus or the 2B33F and 2B33F TS(+) viruses by this RSV-CAT minireplicon system has also been conducted. All three viruses supported both the 2B and 2B33F 3' genomic promoter mediated transcription/replication functions. However, the 2B33F and 2B33F TS(+) viruses preferred their 2B33F 3' genomic promoters. This analysis clearly shows co- evolution of 3 ' genomic promoter changes during the vaccine attenuation process, along with the RNA dependent RNA polymerase gene. Reversion of ts phenotype in the 2B33F mutant 5a by reversion of the single L protein amino acid 451 (Arg —» Lys) by sequence analysis was clearly demonstrated by support of transcription/replication functions of RSV-CAT minireplicon at 37°C. The 2B33F virus did not provide helper functions to the RSV-CAT minireplicon (with 2B or 2B33F 3' genomic promoters) at 37°C.

d. A biased hypermutation of SH seen in 2B33F is present in all 2B33F revertants, regardless of phenotype, and is not seen in 2B20L, which is ts, ca, and attenuated. Thus, there are no data at this time that associate this mutation with any biological phenotype .

Another wild- type RSV designated 18537 was also sequenced and compared to the sequence of the wild-type RSV 2B strain. With one exception, at all the critical residues described above, the two wildtype strains were identical. For 2B, the codon ACA at nucleotides 14586-14588 encodes a Thr at amino acid 2029 of the L protein, while for 18537, the codon ATT at nucleotides 14593-14595 encodes an lie at amino acid 2029 (the L gene start codon is at nucleotides 8509- 8511 in 18537, compared to 8502-8504 in 2B) .

Example 4 PCR Assay to Detect Measles Virus

A 21 year old patient was admitted to a hospital with a three week history of progressive nonproductive cough, shortness of breath, and fever. His symptoms failed to improve following treatment with clarithromycin for seven days or after a similar course of treatment with atovaquone. Concomitant complaints of right upper quadrant abdominal pain proved recalciltrant to omeprazole and antacids. Relevant past medical history included Factor VIII deficiency and HIV infection diagnosed 3-4 years prior to this hospital admission. One year earlier, he had received a booster immunization of measles-mumps-rubella (MMR) vaccine as required for college enrollment.

Bronchoalveolar lavage and transbronchial biopsies performed two days after admission to the hospital demonstrated reactive hyperplasia and alveolar lining cell desquamation with minimal chronic inflammation. No microorganisms were revealed by Gram, methenamine silver, or PAS stains. CT scans of the chest showed multiple, ill-defined, confluent nodules at the left lung base. Despite administration of empiric antimicrobials for opportunistic bacterial, mycobacterial, and fungal pathogens commonly responsible for pulmonary complications of advanced HIV disease, the patient became and remained febrile to

39°C. A left-sided pleural effusion developed; diagnostic thoracentesis showed it to be exudative but otherwise non-diagnostic. Bronchoalveolar lavage performed three weeks later only demonstrated alveolar histiocytes, some of which were hemosiderin laden, a few lymphocytes, and neutrophils. FITE, AFB, and methanamine silver stains again were negative.

Two weeks thereafter, a wedge resection of the left lung was performed through CT-guided minithoracotomy. Multiple tissue sections revealed nodular areas of acute and chronic inflammation with regions of necrosis and fibrosis . Numerous multinuclated giant cells were present, some of which contained both intracytoplasmic and intranuclear inclusions suggestive of measles virus giant cell pneumonia. Special stains for bacteria, fungi, P. carinii , and acid fast organisms again gave negative results. Electron microscopic examination of sections of this lung biopsy revealed particles morphologically consistent with paramyxoviruses such as measles virus. Serum anti-measles IgM titers determined by a solid phase hemadsorbant assay were negative, as was a subsequent IgM capture immunoassay.

Two weeks later, Rhesus monkey kidney (RMK) tissue culture cells inoculated with the patient's lung biopsy material revealed cytopathic changes characteristic of measles virus infection. Confirmation was obtained using an immunofluorescence assay with monoclonal antibodies directed to measles virus. Based upon this diagnosis, oral ribavirin lOOO g B.I.D. was given for 14 days. Unfortunately, the patient progressively deteriorated, eventually dying two months later.

In order to ascertain the nature of the measles virus present in the patient, reverse transcription and PCR amplification of virus obtained from infected tissues were performed, followed by sequence analysis. The measles virus isolated from Rhesus monkey kidney cells inoculated with tissue from this patient's lung biopsy was propagated by two serial passages in the continuous Vero (monkey kidney) tissue culture cell line. Total infected cell RNA was extracted at the second Vero cell passage using TRIzol reagent (Life Technologies, Grand Island, NY) according to the manufacturer's protocol. Total RNA was similarly extracted from the patient's lung biopsy material. The measles virus vaccine strain (Moraten) currently used in the United States as a component of the trivalent MMR vaccines, was obtained in its univalent form (Attenuvax™, Merck, Sharpe, & Dohme) . This virus was passaged once in Vero cells and total vaccine infected cellular RNA then was extracted as described above.

Each of these RNA preparations was reverse transcribed (RT) to cDNA using random hexameric primers and Maloney murine leukemia virus reverse transcriptase (Perkin-Elmer/Cetus RT-PCR kit reagents, Perkin-Elmer- Cetus, Branchburg, NJ) . The cDNA then was amplified by PCR using measles virus-specific oligodeoxynucleotide primer pairs whose design was based on the Edmonston measles virus sequence described above. These PCR products comprised a set of overlapping DNA fragments spanning the entire 15,894 nucleotide long measles genome. A consensus genomic sequence was established by direct analysis of each PCR product, without cloning, using the dideoxy terminator cycle-sequencing method established by the manufacturer (ABI PRISM 377 sequencer and ABI PRISM DNA sequencing kit; Perkin- Elmer/Cetus, Foster City, CA) . Both strands of the PCR-amplified DNA products were analyzed to eliminate possible sequencing ambiguities.

The nucleotide sequences of selected regions of the measles virus genomes present in the patien ' s viral isolate, as well as in the diseased lung tissue, were compared with that of the Moraten vaccine virus, as well as with the nucleotide sequences of other measles virus wild-type and vaccine strains. This sequence analysis revealed identity to the Moraten vaccine strain rather than demonstrating relatedness to past or currently circulating wild-type viruses or other measles vaccine strains. Example 5 ELISA to Detect RSV

An ELISA test is used to detect the presence of RSV. Peptides are designed and selected based on homologies to the RSV sequences described herein to be specific for all subgroup B strains, or for individual wild- type, vaccine or revertant RSV subgroup B strains described herein. These peptides are then coupled to KLH and used to immunize rabbits for the production of monospecific polyclonal antibody. A selection of these polyclonal antibodies, or a combination of polyclonal and monoclonal antibodies is then used in a "capture ELISA" to detect the presence of an RSV antigen.

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90. U.S. Patent Application No. 08/059,444.

SEQUENCE LISTING

(1) GENERAL INFORMATION:

(i) APPLICANT: Udem, Stephen A.

Sidhu, Mohinderjit S. Tatem, Joanne M. Murphy, Brian R. Randolph, Valerie B.

(ii) TITLE OF INVENTION: 3' Genomic Promoter Region and

Polymerase Gene Mutations Responsible for Attenuation in Viruses of the Order Designated Mononegavirales

(iii) NUMBER OF SEQUENCES: 79

(iv) CORRESPONDENCE ADDRESS:

(A) ADDRESSEE: American Home Products Corporation

(B) STREET: One Campus Drive

(C) CITY: Parsippany

(D) STATE: New Jersey

(E) COUNTRY: United States

(F) ZIP: 07054

(v) COMPUTER READABLE FORM:

(A) MEDIUM TYPE: Floppy disk

(B) COMPUTER: IBM PC compatible

(C) OPERATING SYSTEM: PC-DOS/MS-DOS

(D) SOFTWARE: Patentln Release #1.0, Version #1.30

(vi) CURRENT APPLICATION DATA:

(A) APPLICATION NUMBER: US

(B) FILING DATE:

(C) CLASSIFICATION:

(viii) ATTORNEY/AGENT INFORMATION:

(A) NAME: Gordon, Alan M.

(B) REGISTRATION NUMBER: 30,637

(C) REFERENCE/DOCKET NUMBER: 33,294 PCT

(ix) TELECOMMUNICATION INFORMATION:

(A) TELEPHONE: 973/683-2157

(B) TELEFAX: 973/683-4117

(2) INFORMATION FOR SEQ ID Nθ:l:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID Nθ:l:

ACCAAACAAA GTTGGGTAAG GATAGATCAA TCAATGATCA TATTCTAGTG CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTT CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTO TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAATTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCCCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GAAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAC CTTTACCAGC 1020

AAATGGGGGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTAAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260

GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320 AGATCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCGAGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGAG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGCCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCTTCC AACCGGCACA CCCCTAGACA TTGACACTGC ATCGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTTAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTATAGTGTA CAATGACAGA AATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GACCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCATCA ACCATCCACT CCCACGATTG 1800

GAGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC ACCTGCAGGG AAGAGAAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGCCAGG GACCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCCCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGGACCCC 2460

GGTAGGGCCA GCACTTCCGA GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880 AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ATGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360

CCAGTCGACC CAACTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCCACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGGC AGCGATCCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CCCTGCCCTT AGGTGTTGGC AGATCCACAG CAAAGCCCGA AGAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTCGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATAGGC CCTGGGAAGA TCATCGACAA TACAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AGATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCGCTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380

AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440 TGTAGACCGT AGTGCCCAGC AATGCCCGAA AACGACCCCC CTCACAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCGAAAGAC TCCACGGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACGGCA AGCGCGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCTGA CACAAGGCCA 4620

CCACCAGCCA CCCCAATCTG CATCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGC 4680

TGCCCCCGAT CCAAACCACC AACCGCATCC CCACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ATTGGAAGGC CCCTCCCCCT CTTCCTCAAC ACAAGAACTC CACAACCGAA CCGCACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC TCCCCGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGCCCA 4920

CGGCGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGTTC 4980

CCCCGGTGCC CACAGGCAGG GACACCAACC CCCGAACAGA CCCAGCACCC AACCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGCCC CGATCCGGCG GGGAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCTTT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAACTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAGACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940

GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000 ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAC 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TCCACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGAGGTATCC AGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTCTACAT CCTGATTGCA 6960

GTGTGTCTTG GAQGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACGGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCACCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TCATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTTG TCATGTCTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560 AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTAGA CTTGTATTTA AGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGCAAAAGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATCTTGA 8100

GCAACCAGTC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCTTATCA ACGGATGATC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAAC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTGATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAATCCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC AACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAGGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACATA TCACTCACTC 9060

TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATCGCAG 9120 ATAGGGCTGC TAGTGAACCA ATCACATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240

CGCTATCTGT CAACCAGATC TTATACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ATAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540

CGAGGAAGAT CCGTGAACTC CTCAAAAAGG GGAATTCGCT GTACTCCAAA GTCAGTGATA 9600

AGGTTTTCCA ATGCTTAAGG GACACTAACT CACGGCTTGG CCTAGGCTCC GAATTGAGGG 9660

AGGACATCAA GGAGAAAGTT ATTAACTTGG GAGTTTACAT GCACAGCTCC CAGTGGTTTG 9720

AGCCCTTTCT GTTTTGGTTT ACAGTCAAGA CTGAGATGAG GTCAGTGATT AAATCACAAA 9780

CCCATACTTG CCATAGGAGG AGACACACAC CTGTATTCTT CACTGGTAGT TCAGTTGAGT 9840

TGCTAATCTC TCGTGACCTT GTTGCTATAA TCAGTAAAGA GTCTCAACAT GTATATTACC 9900

TGACATTTGA ACTGGTTTTG ATGTATTGTG ATGTCATAGA GGGGAGGTTA ATGACAGAGA 9960

CCGCTATGAC TATTGATGCT AGGTATACAG AGCTTCTAGG AAGAGTCAGA TACATGTGGA 10020

AACTGATAGA TGGTTTCTTC CCTGCACTCG GGAATCCAAC TTATCAAATT GTAGCCATGC 10080

TGGAGCCTCT TTCACTTGCT TACCTGCAGC TGAGGGATAT AACAGTAGAA CTCAGAGGTG 10140

CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGATGTTCT TGACCAAAAC GGGTTTTCTG 10200

ATGAAGGTAC TTATCATGAG TTAATTGAAG CTCTAGATTA CATTTTCATA ACTGATGACA 10260

TACATCTGAC AGGGGAGATT TTCTCATTTT TCAGAAGTTT CGGCCACCCC AGACTTGAAG 10320

CAGTAACGGC TGCTGAAAAT GTTAGGAAAT ACATGAATCA GCCTAAAGTC ATTGTGTATG 10380

AGACTCTGAT GAAAGGTCAT GCCATATTTT GTGGAATCAT AATCAACGGC TATCGTGACA 10440

GGCACGGAGG CAGTTGGCCA CCGCTGACCC TCCCCCTGCA TGCTGCAGAC ACAATCCGGA 10500

ATGCTCAAGC TTCAGGTGAA GGGTTAACAC ATGAGCAGTG CGTTGATAAC TGGAAATCTT 10560

TTGCTGGAGT GAAATTTGGC TGCTTTATGC CTCTTAGCCT GGATAGTGAT CTGACAATGT 10620

ACCTAAAGGA CAAGGCACTT GCTGCTCTCC AAAGGGAATG GGATTCAGTT TACCCGAAAG 10680 AGTTCCTGCG TTACGACCCT CCCAAGGGAA CCGGGTCACG TTAATGATTC GAGCTTTGAC CCATATGATG TGATAATGTA TCCATGACCC TGAGTTCAAC CTGTCTTACA GCCTGAAAGA GTAGACTTTT TGCTAAAATG ACTTACAAAA TGAGGGCATG TAATCTCAAA CGGGATTGGC AAATATTTTA AGGACAATGG ATTTGACTAA GGCACTCCAC ACTCTAGCTG TCTCAGGAGT GTCACAGGGG GGGGCCAGTC TTAAAAACCT ACTCCCGAAG GGAACGTGAG AGCAGCAAAA GGGTTTATAG GGTTCCCTCA ACACTGATCA TCCGGAGAAT ATGGAAGCTT ACGAGACAGT ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT TAAATGAGAT TTACGGATTG CCCTCATTTT TCCAGTGGCT CTGTCCTGTA TGTAAGTGAC CCTCATTGCC CCCCCGACCT ATAAAGTCCC CAATGATCAA ATCTTCATTA AGTACCCTAT GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATCTATA GAGTAAGGAT TGCTTCGTTA GTGCAAGGGG ACAATCAGAC TACCCAGCAC ATGGCCCTAC AACCTTAAGA AACGGGAAGC ACTTTGTAAT TCTTAGGCAA AGGCTACATG ATATTGGCCA CAATTGTTTC ATCACATTTT TTTGTCTATT CAAAAGGAAT TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT CTCTTGGCTT CACAATCAAT TCAACCATGA CCCGGGATGT ACAACGACCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC ATCTCAAGAG AATGATTCTC GCCTCACTAA TGCCTGAAGA CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTG GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 125 0

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCT CTAAGAAGCC 12660

ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CTAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCGAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTCATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800 AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTCTTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTAT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 14160

ATATCAAGGC AGAGGCTAGG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280

GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGATTTCAGA CCCCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAAG 14580

ACGGCTTGTT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAG GAGATACTTA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820

TCAATTTCAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTGCC TAACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTCA TTATAGAGAA GTGAACCTTG 15060

TATACCCTAG ATACAGCAAC TTCATATCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120

AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGA 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360 AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TTTGGGGGCA CATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGCTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ACTAATTGGT TGAACTCCGG AACCCTAATC CTGCCCTAGG TGGTTAGGCA TTATTTGCAA 15840

TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894 (2) INFORMATION FOR SEQ ID NO: 2:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 2:

Met Asp Ser Leu Ser Val Asn Gin lie Leu Tyr Pro Glu Val His Leu 1 5 10 15

Asp Ser Pro lie Val Thr Asn Lys lie Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Asn 35 40 45

He Lys His Arg Leu Lys Asn Gly Phe Ser Asn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser His He Pro Tyr Pro Asn Cys Asn Gin Asp Leu Phe Asn 85 90 95 He Glu Asp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lys Glu Lys Val He Asn Leu Gly Val Tyr Met His Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cys His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Asp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lys Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cys Phe Thr Glu He His Asp Val Leu Asp Gin Asn Gly 305 310 315 320

Phe Ser Asp Glu Gly Thr Tyr His Glu Leu He Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Asp Asp He His Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cys Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lys Phe 435 440 445

Gly Cyβ Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 450 455 460

Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Asp 500 505 510

Val He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Asn Gly 565 570 575

Met Ala Lys Asp Glu His Asp Leu Thr Lys Ala Leu His Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lys Asp Leu Lys Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Asn 610 615 620

Val Arg Ala Ala Lys Gly Phe He Gly Phe Pro Gin Val He Arg Gin 625 630 635 640

Asp Gin Asp Thr Asp His Pro Glu Asn Met Glu Ala Tyr Glu Thr Val 645 650 655 Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lys Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cys Pro Pro Asp Leu Asp Ala His He 705 710 715 720

Pro Leu Tyr Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lys Lys Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Asp Tyr Phe Val He Leu Arg Gin Arg Leu His Asp He Gly His 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830

Ser Lys Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Asp Val Val He Pro Leu Leu Thr Asn Asn Asp Leu Leu He 915 920 925 Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lys Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cys Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Asn He Thr Ala Arg Phe Val Leu He His 1010 1015 1020

Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Asp Asp Ser Lys Glu 1025 1030 1035 1040

Glu Asp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Asp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lys Arg Asn Val Leu He Asp Lys Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg His Glu Thr Cys Val He Cys Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Asp 1185 1190 1195 1200

He Asp Lys Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Asp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Asp Asp Asp Ser Ser Trp Asn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Asn Leu Ala His Arg Leu Arg Asp Arg Ser Thr Gin 1285 1290 1295

Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lys Lys Val Asp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu His Val Glu Thr Asp Cys Cys Val He Pro Met He Asp 1365 1370 1375

His Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu He Tyr Asp Asn Ala Pro Leu He Asp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser His Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Asp Leu Val Thr Lys Phe Glu Lys Asp His Met 1445 1450 1455

Aβn Glu He Ser Ala Leu He Gly Asp Asp Asp He Asn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485 Gin Cys Ala Ala He Asn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Asn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565

Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Asp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Asn He Gin Ala Lys His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cys Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Asn He Asn Pro He He Val 1650 1655 1660

Asp His Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Asp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Asp Phe Arg Pro Pro His Asp Asp Val Ala Lys Leu 1715 1720 1725

Leu Lys Asp He Aβn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Aβn Leu Ala Asn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760 Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cys Phe 1795 1800 1805

Tyr Asn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Asp Cys Phe Asn Phe He Val Ser Asn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He His Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lye Ala Asn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lye Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Asp Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

Thr Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His His Asp 2035 2040 2045

Val Ala Ser Gly Gin Asp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly His He Leu Leu Tyr Ser Gly 2100 2105 2110

Asn Arg Lys Leu He Asn Lys Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Asp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr Val Lys Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 3:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: DNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 3:

ACCAAACAAA GTTGGGTAAG GATAGATCAA TCAATGATCA TATTCTAGTA CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTC 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCGGGA GATTCCTCAA 240 TTACCACTCG ATCTAGACTT CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATATTTT TCACATGATG ATCCAAGTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCTCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GGAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAT CTTTACCAGC 1020

AAATGGGGGA AACTGCACCA TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTCGA TCCAGCATAT TTCAGACTAG 1200

GGCAAGAGAT GGTGAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260

GTATCACTGC CGAAGATGCA AGGCTTGTTT CAGAGATCGC AATGCATACT ACAGAGGACA 1320

GGATCAGTAG AGCGGTTGGA CCCAGACAAT CCCAAGTGTC ATTCCTACAC GGTGATCAAA 1380

ATGAAAATGA GCTACCGAGA TGGGGGGGTA AGGAAGATAT GAGGGTCAAA CAGAGTCGGG 1440

GAGAAGCCAG AGAGAGCTAC AGAGAAACCA GGCCCAGCAG AGCAAGTGAC GCGAGAGCTA 1500

CCCATCCTCC AACCGACACA CCCTTAGACA TTGACACTGC ATCGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTCAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTAGAGTGTA CAATGACAGA GATCTTCTAG 1680

ACTAGGTGCA AGAGGCCGAG GACCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCACCA ACCATCCACT CCCACGATTG 1800 GGGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC GCCTGCAAGG AAGAGAAGGC AAGCAGTCCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GATCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCTCAGGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCAAA GCTTAGGAAA ACTCTCAATG TTCCCCCGCC CCCGGACCCT 2460

GGTAGGGCCA GCACTTCCGA GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGTACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA TTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCACCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGGGA AGTTGAGTCA ATCAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCTTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCTGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

ATCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCGGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 32 0

CGTTACCTGA TGACTCTCCT TGATGACATC AAAGGAGCCA ACGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360 CCAGTCGACC TAGCTAATAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCCACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GAAAAGATGA ATGTTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATCTCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CTCTGCCCTT AGGTGTTGGC AGATCCACAG CAAAACCCGA AGAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCATACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTGGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCAGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATTGGC CATGGGAAGA TCATCGACAA TGCAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA AAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCCTATGT TACCCACTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380

AAGAATTCCG CATTTACGAC GACGTTATCA TAAATGATGA CCAAGGATTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATGCCCGAA GACGACCCTC CTCACAATGA CAGCCAGAAG 4500

GCCCGGAAAA AAAGGCCCCC TCCGAAAGAC TCCACAGACC AAATGAGAGG CCAGCCAGCA 4560

GCTGACGGCA AGCACGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCTGA CATAAGGCCA 4620

CCACCAGCCA TCCCAATCTG CATCCTCCTC GTAGGACCCC CGAGGACCAA CCCCCAAGGT 4680

TGCCCCCCAC CCAAACCACC AACCGCATCC CTACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ACTGGAAGAG CCCTTCCCCT TTCCCTCAAC ACAAGAACTC CACAACCGAA CCACACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCACCCGA CTCCCTAGAC AGATCCTCTC CCCCTGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGCCCA 4920 CGGCGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG CACACCAACC CCCGAACAGA CCCAGCACCC AGCCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGACAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG TTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCTGCGC 5220

ACCCCAGCCC CGATCCGGCG GGCAGCCACC CAACCCTAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCTTCCTCT TCTCGAAGGG ACTAAAAGAT CAATCCACCA CATCCGACGA CACTCAACTC 5400

CCCGTCCCTA AAGGAGACAC CGGGAATCCC GGAATTAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGTTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCAG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGG GCAAGTCTGG AAACTACTAA TCAGGCAATT 5940

GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCTAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT CGGAGGAGAT 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAT AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ACCCGACGCT GTCCGAGATC AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACGACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480 GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TCCACCAAGT CCTGTGCTCG TACACTCGTA TCTGGGTCTT TTGGGAACCG GTTCATTTTG 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGAGGTATCC AGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTGTCG AGCACTAGCA TAGTCTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACAGGA 7080

ACATCGAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGGAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCATCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TCCCCTTTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TTATCAACAG AGAACACCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTCG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CAATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TTGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAACCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTGGA CTTGTATTTA AGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTACGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGCAAAGGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040 - Ill

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATTTTGA 8100

GCAACCAGTC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACGGGGGAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTTCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCTTCTCA ACGGATGACC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTAT CCCGACAACA AGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAGC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGAGTCTTGT CTGTTGATCT 8520

GAGTCTAACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAGTCCAA CCACAACAAT GAGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCC TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC AACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATCCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGATCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACATA TCACTCACTC 9060

TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATAGCAG 9120

ATAGGGCTGC CAGTGAACCA ATCACATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240

CGCTATCTGT CAACCAGATC TTATACCCCG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ACAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAC TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540

CGAGGAAGAT CCGTGAACTC CTCAAAAAGG GAAATTCGCT GTACTCTAAA GTCAGTAATA 9600 ACACTAATCA TCCGGAGAAT ATGGAAGCTT ACGAGACAGT CAGTGCATTT ATCACAACTG 11220

ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT CAGCTTGTTT GCACAGAGGC 11280

TAAATGAGAT TTACGGATTA CCCTCATTTT TTCAGTGGCT GCATAAGAGG CTTGAGACCT 11340

CTGTCCTGTA TGTAAGTGAC CCTCATTGCC CCCCCGACCT TGACGCCCAT ATCCCGTTAT 11400

GCAAAGTCCC CAATGACCAA ATCTTCATTA AGTACCCTAT GGGAGGTATA GAAGGGTATT 11460

GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATTTATA CCTGGCTGCT TATGAGAGCG 11520

GAGTAAGGAT TGCTTCATTA GTGCAAGGGG ACAATCAGAC CAT GCTGTA ACAAAAAGGG 11580

TACCCAGCAC ATGGCCTTAC AACCTTAAGA AATGGGAAGC TGCTAGAGTA ACTAGAGATT 11640

ACTTTGTAAT TCTTAGGCAA AGGCTACATG ACATTGGCCA TCACCTCAAG GCAAATGAGA 11700

CAATTGTTTC ATCACATTTT TTTGTTTATT CAAAAGGAAT ATATTATGAT GGGCTACTTG 11760

TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG GTCAGAGACT ATAGTTGATG 11820

AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC TAAAAGCATC GAGAGAGGTT 11880

ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT GATACAGCAG ATTCTGATCT 11940

CTCTTGGCTT CACAATCAAT TCAACCATGA CCCAGGATGT AGTCATACCC CTCCTCACAA 12000

ACAACGACCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TATTGGGGGG ATGAATTATC 12060

TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC AGTAACATCA TCAATTGCTG 12120

ATCTCAAGAG AATGATTCTC GCATCACTGA TGCCTGAAGA GACCCTCCAT CAAGTAATGA 12180

CACAGCAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTAA 12300

TCCACAGTCC AAACCCAATG TTAAAGGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC AGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTA GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTAACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCC CTAAGAAGCC 12660

ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720 TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CAAGGCAAAG GGCTAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCACATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCAAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGA ACT AACTTTATAT ACCAACAAGG AATGCTCCTA GGGTTGGGCG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CAATGATAGA TCATCCCAGG ATACCCAGCT 13380

CTCGCAAGCT AGAGCTGAGG GCAGAGCTGT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTAG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTCT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTTATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCACTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTTACA TTTCTTTTGT GTGAAAGTGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTGT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 14160

ATATCAAGGC GGAGGCTAGG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTTCGGCG AGGATCGATC AAACAGATAA 14280 GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGATTTCAGA CCCCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ATACAAGCAA GCACAATCTT CCCATTTCTG 14460

GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAAG 14580

ACGGCTTATT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAG GAGATACTTA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TCTCTGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAGGT GCTCTTTAAC GGGAGGCCCG AAGTCACATG GGTAGGCAGT GTAGATTGCT 14820

TCAATTACAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTACC TAACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTCA TTATAGAGAA GTGAACCTTG 15060

TATACCCCAG ATACAGCAAC TTCATATCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120

AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGC 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAA CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAGGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGAATC ACTCGCAAAT 15540

TTTGGGGGCA CATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGTTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAG GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ACTAATTGGT TGAACTCCGG AACCCTAATC CTGCCCCAGG TGGTTAGGCA TTATTTGTAA 15840 TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894

(2) INFORMATION FOR SEQ ID NO: 4:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4:

Met Asp Ser Leu Ser Val Asn Gin He Leu Tyr Pro Glu Val His Leu 1 5 10 15

Asp Ser Pro He Val Thr Asn Lys He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Asn 35 40 45

He Lys His Arg Leu Lys Asn Gly Phe Ser Asn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lye Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser His He Pro Tyr Pro Asn Cys Asn Gin Asp Leu Phe Asn 85 90 95

He Glu Asp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asn Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lys Glu Lys Val He Asn Leu Gly Val Tyr Met His Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cys His Arg Arg Arg His Thr 180 185 190 Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Asp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lys Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cys Phe Thr Glu He His Asp Val Leu Asp Gin Asn Gly 305 310 315 320

Phe Ser Asp Glu Gly Thr Tyr His Glu Leu Val Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Asp Asp He His Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cys Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lys Phe 435 440 445

Gly Cyβ Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 450 455 460 Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Asp 500 505 510

Met He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Asn Gly 565 570 575

Met Ala Lys Asp Glu His Asp Leu Thr Lys Ala Leu His Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lys Asp Leu Lys Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr Tyr Ser Arg Ser Pro Ala His Thr Asn Thr Arg Asn 610 615 620

Val Arg Ala Ala Lys Gly Phe He Gly Phe Pro Gin He He Arg Gin 625 630 635 640

Asp Gin Asp Thr Aβn His Pro Glu Asn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lys Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cys Pro Pro Asp Leu Asp Ala His He 705 710 715 720

Pro Leu Cys Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Aβp Aβn Gin Thr He Ala Val Thr Lye Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lys Lys Trp Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Asp Tyr Phe Val He Leu Arg Gin Arg Leu His Asp He Gly His 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830

Ser Lys Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Gin Asp Val Val He Pro Leu Leu Thr Asn Asn Asp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Aβn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lys Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cys Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Asn He Thr Ala Arg Phe Val Leu He His 1010 1015 1020 Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Asp Asp Ser Lye Glu 1025 1030 1035 1040

Glu Asp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Asp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lys Arg Aβn Val Leu He Asp Lys Glu Ser Cyβ Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg Hie Glu Thr Cys Val He Cys Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Asp 1185 1190 1195 1200

He Asp Lys Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Aβp Met Lye Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Aβp Asp Asp Ser Ser Trp Asn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Asn Leu Ala His Arg Leu Arg Asp Arg Ser Thr Gin 1285 1290 1295 Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lys Lys Val Asp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu Hie Val Glu Thr Asp Cyβ Cys Val He Pro Met He Asp 1365 1370 1375

His Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu He Tyr Asp Asn Ala Pro Leu He Asp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser His Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Aβp Leu Val Thr Lye Phe Glu Lye Asp His Met 1445 1450 1455

Asn Glu He Ser Ala Leu He Gly Asp Asp Asp He Asn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Asn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Asn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565

Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Asp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Aβn He Gin Ala Lys His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cys Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Asn He Asn Pro He He Val 1650 1655 1660

Asp His Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Asp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Aβn 1700 1705 1710

Met Ser He Lys Aβp Phe Arg Pro Pro Hie Aβp Aβp Val Ala Lye Leu 1715 1720 1725

Leu Lys Asp He Asn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Asn Leu Ala Aβn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760

Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lye Cys Phe 1795 1800 1805

Tyr Aβn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855 Val Gly Ser Val Asp Cys Phe Asn Tyr He Val Ser Asn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He His Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Asn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lys Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Asp Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

Thr Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His His Asp 2035 2040 2045

Val Ala Ser Gly Gin Aβp Gly Leu Leu Aβn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly Hie He Leu Leu Tyr Ser Gly 2100 2105 2110

Aβn Arg Lys Leu He Asn Lys Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125 Leu He Leu Asp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr Val Lys Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 5:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: DNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 5:

ACCAAACAAA GTTGGGTAAG GATAGATCAA TCAATGATCA TATTCTAGTA CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTA CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTGTTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATCAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAAGTAG TAGTGATCAA TCCAGGTCCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATTCTA GCCCAAATTT GGGTCTTGCT CGCGAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTCAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780 AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGGACACCCG 840

GGAACAAACC AAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTA ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAT CTTTACCAGC 1020

AAATGGGAGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCCCTG CTCTGGAGCT ATGCCATGGG AGTAGGGGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGTCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTGAGGAGG TCAGCTGGGA AAGTCAGTTC CACATTAGCA TCTGAACTCG 1260

GTATCACTGC TGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCACACT ACTGAGGACA 1320

GGACCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTGTC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCAGGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGGG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGTCTAGCAG AGCAAGCGAT GCGAGAGCTG 1500

CCCATCTTCC AACCAGCGCA CCCCTAGACA TTGACACTGC ATCGGAGTCA GGCCAAGATC 1560

CGCAGGACAG TCGACGGTCA GCTGACGCCC TGCTCAGGCT GCAAGCCATG GCAGGAATCT 1620

TGGAAGAACA AGGCTCAGAC ACGGACACCC CTAGGGTGTA CAATGACAGA GATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GACCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCAACCA ACCATCCACT CCTACGACTG 1800

GGGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC GTCGAGGAAG CCATGGCAGC ATGGTCACAA 1920

ATATCAGACA ACCCAGGACA GGACCGAACC ACCCGCAAGG AAGAGGAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCAGTGC ACCTCGCATC 2040

TGCGGTCAGG GATCTGGAGA GAGCGATGAC AACGCTGAAA CTTTGGGAAT CCCCTCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATCATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CGATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340 GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCT 2400

AGAGGCAACA ACTTCCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGAACCCC 2460

GGTAGGGCCA GCACTTCCGA GACACCCATT AAAAAGGGGA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAGCGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GTGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA TTATTATGAT GATGAGCTGT TCTCCGATGT CCAAGACATC 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAAAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAACTCAATC CCGACCTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAA 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCC 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ACGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCTCATG 3360

CCAATCGACC TAATTAGTAC AGCCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCTACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTACG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATCCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CCCTGCCCTT AGGTGTTGGT AGATCCACAG CAAAACCCGA AGAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTCGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTGGATACC CCGCAGAGGT 3900 TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT AGAATTCAGA TCGGTCAATG CAGTGGCTTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA AGCGATTGGC CCTGGGAAGA TCATCGATAA TGCAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCTG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAAAA GACCTTATGT TACCCACTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCCC 4380

AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATACCCGAA AACGACCCCC CTCATAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCAAAAGAC TCCACGGACC AAGTGAGAGG CCAGCCAGCA 4560

GCTGACGGCA AGCGTGAACA CCAGGCGGCC TGGGCACAGA ACAGCCCCGA CACAAGGCAA 4620

CCACCAGCCA TCCCAATCTG CGTCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGT 4680

CGCCCCCGAC CCAGACCACC AACCGCATCC CCACAGCCCC CGGGAAAGAG ACCCCCAGCA 4740

ACTGGAAGGC CCCTCCCCCT TTCCCTCAAC GCAAGAACTC CACAACCGAA CCGCACAAGC 4800

GATCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC CCCCCGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCGAC AGAACCCAGA CCCCGGCCCA 4920

CGGCGCCGCG CCCCCACCTC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG CACACCAACC CTCGAACAGA CCCAGCACCC AGCCATCGAC 5040

AATTCAAGAC GGGGGGCCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CAGGAACCGA ACCAGAATCC AGACCACCCT 5160

GGGCCACCAG TTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCTGCCC TGATCCGGTG GGCGGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGGCCC CCGAACCGCA AAAGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCCCCTCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAATTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460 GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGGAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCTG GAGTTGTCCT GGCGGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

TTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940

GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTAGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CACTATTTGG CCCCAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAT 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTACTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GC AGAAGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TCCACCAAGT CCTGTGCTCG TACACTTGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ATCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAGGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTGGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGCGGTATCC GGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTTTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020 AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACAGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCATCCA GCATCGAGCC CACCTGAAAT 7200

TGTCTCCGGA TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ACAACCCCCA 7320

TCCTAGGGGA AGTAGGATAG TTATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTATTCG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATAAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

GATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACCGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAACTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGG CCAGGGTAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTGGA CTTGTATTTA AATCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTACGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGTAAAGGGT CAGAGTTGTC ACAACTGAGC ATGCACCGAG TGTTTGAAGT 8040

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATTTTGA 8100

GCAACCAGTC AGTAATGATT TCAGCAACTG CATGGTGGCT TTGGGGGAGC TCAAATTCGC 8160

AGCCCTTTGT CACAGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCCTATCA ACGGATGATC CAGTGATAGA CAGGCTCTAC CTCTCATCTC ACAGAGGCGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGGACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAGC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTAATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCAGGA TTCGGGCCAT TGATCACACA 8580 GCCAATGAAG AACCTAGCCT GGTTAGTCCC TACCTCTTCA AACATACCTA CCTGCGGAGG ACCTGGTCAA GATCTCCAAT TGTGGTTTAT TACGTTTACA GCCTATAAGG GGGGTCCCCA CTGGTGCCGT CACTTCTGTG TGGGATGGTG GGCATGGGAG ATAGGGCTGC CAGTGAACCA GTGAAATAGA CATCAGAATT CGCTATCTGT CAACCAGATC ATAAGATAGT AGCTATCCTG CTACACTGTG TCAGAACATC TAAACAATGT GGAAGTTGGG CTCATATTCC ATATCCAAAT CAAGGAAGAT CCGTGAGCTC AGGTTTTCCA ATGCCTGAGG AGGACATCAA GGAGAAAATT AGCCCTTTCT GTTTTGGTTT CCCATACTTG CCATAGGAGG TGCTAATCTC TCGTGACCTT TGACGTTTGA ACTGGTCTTG CCGCTATGAC CATTGATGCT AACTGATAGA TGGTTTCTTC TGGAGCCTCT TTCACTTGCT CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGATGTTCT TGACCAAAAC GGGTTTTCTG 10200

ATGAAGGTAC TTATCATGAG TTAATTGAAG CCCTAGATTA CATTTTCATA ACTGATGACA 10260

TACATCTGAC AGGGGAGATT TTCTCATTTT TCAGAAGTTT CGGCCACCCC AGACTTGAAG 10320

CAGTAACGGC TGCTGAAAAT GTTAGGAAAT ACATGAATCA GCCTAAAGTC ATTGTGTATG 10380

AGACTCTGAT GAAAGGTCAT GCCATATTCT GTGGAATCAT AATCAACGGC TATCGTGACA 10440

GGCACGGAGG CAGTTGGCCA CCCCTGACCC TCCCCCTGCA TGCTGCAGAC ACAATCCGGA 10500

ATGCTCAAGC TTCAGGTGAA GGGTTAACAC ATGAGCAGTG CGTTGATAAC TGGAAATCTT 10560

TTGCTGGAGT GAAATTTGGC TGCTTTATGC CTCTTAGCCT GGATAGTGAT CTGACAATGT 10620

ACCTAAAGGA CAAGGCACTT GCTGCTCTCC AAAGGGAATG GGATTCAGTT TACCCGAAAG 10680

AGTTCCTGCG TTACGACCCT CCCAAAGGAA CTGGGTCACG GAGGCTTGTA AATGTTTTCC 10740

TTAATGATTC GAGCTTTGAC CCATATGACA TGATAATGTA TGTTGTAAGT GGAGCTTACC 10800

TCCATGACCC TGAGTTCAAC CTGTCTTACA GCCTGAAAGA AAAGGAGATC AAGGAAACAG 10860

GTAGACTTTT TGCTAAAATG ACTTACAAAA TGAGGGCATG CCAAGTGATT GCTGAAAATC 10920

TAATCTCAAA CGGGATTGGC AATTATTTTA AGGACAATGG GATGGCCAAG GACGAGCACG 10980

ATTTGACTAA GGCACTCCAC ACTCTAGCTG TCTCAGGAGT CCCCAAAGAT CTCAAAGAAA 11040

GTCACAGGGG GGGGCCAGTC TTAAAAACCC ACTCCCGAAG CCCAGTCCAC ACAAGTACCA 11100

AGAACGTGAG AGCAGCAAAA GGGTTTATAG GATTCCCTCA TGTAATTCGG CAGGACCAAG 11160

ACACTGATCA TCCGGAGAAT ATGGAGGCTT ACGAGACAGT CAGTGCATTT ATCACGACTG 11220

ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT CAGCTTATTT GCACAAAGGC 11280

TAAATGAGAT TTACGGATTA CCCTCATTTT TCCAGTGGCT GCATAAGAGG CTTGAAACCT 11340

CTGTCCTCTA TGTAAGTGAC CCTCATTGCC CCCCTGACCT TGACGCCCAT GTCCCGTTAT 11400

GCAAAGTCCC CAATGACCAA ATCTTCATTA AGTACCCTAT GGGAGGTATA GAAGGGTATT 11460

GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATTTATA CCTGGCTGCT TATGAGAGCG 11520

GAGTAAGGAT TGCTTCGTTA GTGCAAGGGG ACAATCAGAC CATAGCCGTA ACAAAAAGGG 11580

TACCCAGCAC ATGGCCTTAC AACCTTAAGA AACGGGAAGC TGCTAGAGTA ACTAGAGATT 11640

ACTTTGTAAT TCTTAGGCAA AGGCTACATG ACATAGGCCA TCACCTCAAG GCAAATGAGA 11700 CAATTGTCTC ATCACATTTT TTTGTCTATT CAAAAGGAAT ATATTATGAT GGGCTACTTG 11760

TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG GTCAGAGACT ATAGTTGATG 11820

AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC TAAAAGCATC GAGAGAGGTT 11880

ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT GATACAGCAA ATCCTGATCT 11940

CTCTTGGCTT CACAATCAAT TCAACCATGA CCCGGGATGT AGTCATACCC CTCCTCACAA 12000

ACAACGATCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TATCGGGGGG ATGAATTATC 12060

TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC AGTAACATCA TCAATTGCTG 12120

ATCTCAAGAG AATGATTCTC TCATCACTAA TGCCTGAAGA GACCCTTCAT CAAGTAATGA 12180

CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGCGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGGT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTA GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTTAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCTAGAGCC CTAAGAAGCC 12660

ATATGTGGGC AAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GCCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAT GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CAAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTACCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCAAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAGGG AATGCTTCTA GGGTTGGGTG 13260 TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTTAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTTATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCAGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCTTC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTACACA 13920

CAACTGTGTG CAACATGATT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTTCTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA TATCCAGGCA AAACACTTGT GTGTTCTAGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCAATTCGA GGTCTACGAC CTGTAGAGAA ATGTGCAGTT CTAACCGATC 14160

ATATCAAGGC AGAGGCTAGG TTATCTCCAG CAGGGTCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280

GATTGAGAGT TGATCCAGGA TTCATTTTTG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGATTTCAGA CCTCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGTAATCT CGCCAATTAT GAAATCCACG CTTTCCGCAG AATCGGGTTA AACTCATCCG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAAG 14580

ACGGCTTGTT CTTGGGTGAG GGGTCGGGTT CTATGTTGAT CACTTATAAG GAGATACTAA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGTC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820 TCAATTTCAT AGTCAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTACC TAACAAAGAT ACTATAGAGA AGCTAGAGGA ATTAGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTTGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTTA TTATAGAGAA GTGAACCTTG 15060

TCTACCCTAG ATACAGCAAC TTCATATCTA CTGAATCTTA TTTAGTCATG ACAGATCTCA 15120

AAGCTAACCO GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGC 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG GTATCAACCC TATTCTGAAG AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAA CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAACTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCATG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TTTGGGGGCA TATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATCGG TTTATCCAGA 15600

ATCTCAAGTC CGGTTACCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CTAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTAAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAATCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ATTAATTGGT TGGACTCCGG GACCCTAATC CTGCCCTAGG TAGTTAGGCA TTATTTGCAA 15840

TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894 (2) INFORMATION FOR SEQ ID NO: 6:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 6: Met Asp Ser Leu Ser Val Asn Gin He Leu Tyr Pro Glu Val His Leu 1 5 10 15

Asp Ser Pro He Val Thr Asn Lys He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro Hie Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Asn 35 40 45

He Lys Hie Arg Leu Lys Asn Gly Phe Ser Aβn Gin Met He He Aβn 50 55 60

Aβn Val Glu Val Gly Aβn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Thr His Ser His He Pro Tyr Pro Asn Cys Asn Gin Aβp Leu Phe Asn 85 90 95

He Glu Aβp Lye Glu Ser Thr Arg Lye He Arg Glu Leu Leu Lye Lye 100 105 110

Gly Aβn Ser Leu Tyr Ser Lye Val Ser Aβp Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lys Glu Lys He He Asn Leu Gly Val Tyr Met His Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cys His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Asp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lys Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Aβn His Cyβ Phe Thr Glu He Hie Aβp Val Leu Aβp Gin Aβn Gly 305 310 315 320

Phe Ser Asp Glu Gly Thr Tyr His Glu Leu He Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Aβp Aβp He Hie Leu. Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly Hie Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lye Gly Hie Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Aβp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cyβ Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lys Phe 435 440 445

Gly Cys Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 450 455 460

Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asn Val Phe Leu Asn Asp Ser Ser Phe Aβp Pro Tyr Aβp 500 505 510

Met He Met Tyr Val Val Ser Gly Ala Tyr Leu Hie Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560 Glu Asn Leu He Ser Aβn Gly He Gly Asn Tyr Phe Lys Asp Aβn Gly 565 570 575

Met Ala Lys Asp Glu His Aβp Leu Thr Lys Ala Leu His Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lys Asp Leu Lys Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr His Ser Arg Ser Pro Val His Thr Ser Thr Lys Asn 610 615 620

Val Arg Ala Ala Lys Gly Phe He Gly Phe Pro Hie Val He Arg Gin 625 630 635 640

Aβp Gin Aβp Thr Aβp Hie Pro Glu Aβn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Aβp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lye Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Aβp Pro His Cyβ Pro Pro Aβp Leu Aβp Ala Hie Val 705 710 715 720

Pro Leu Cyβ Lye Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Aβp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lys Lye Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Aβp Tyr Phe Val He Leu Arg Gin Arg Leu His Asp He Gly His 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830 Ser Lys Gly He Tyr Tyr Aβp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lye Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Asp Val Val He Pro Leu Leu Thr Asn Asn Asp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lys Arg Met He Leu Ser Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cys Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Aβn He Thr Ala Arg Phe Val Leu He Hie 1010 1015 1020

Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Aβp Asp Ser Lys Glu 1025 1030 1035 1040

Glu Asp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Aβp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lys Arg Aβn Val Leu He Aβp Lye Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Aβp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

Hie Leu He Arg Arg Hie Glu Thr Cyβ Val He Cys Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Aβp 1185 1190 1195 1200

He Aβp Lye Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Asp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Asp Asp Asp Ser Ser Trp Asn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Asn Leu Ala His Arg Leu Arg Asp Arg Thr Thr Gin 1285 1290 1295

Val Lye Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Aβn Asp Asn Leu Ser Phe Val He Ser Asp Lys Lys Val Asp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu His Val Glu Thr Asp Cys Cyβ Val He Pro Met He Asp 1365 1370 1375

His Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390 Cys Thr Asn Pro Leu He Tyr Asp Asn Ala Pro Leu He Asp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser His Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Asp Leu Val Thr Lye Phe Glu Lys Asp His Met 1445 1450 1455

Asn Glu He Ser Ala Leu He Gly Asp Asp Asp He Asn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Aβn Trp Ala Phe Aβp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser Hie Pro 1525 1530 1535

Lye He Tyr Lye Lye Phe Trp Hie Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Aβn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565

He Tyr Thr Cyβ Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Aβp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Aβp Aβn He Gin Ala Lys His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cys Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Asn He Aβn Pro He He Val 1650 1655 1660 Asp Hiβ Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Asp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Aβn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Asp Phe Arg Pro Pro His Asp Aβp Val Ala Lye Leu 1715 1720 1725

Leu Lys Asp He Aβn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Asn Leu Ala Asn Tyr Glu He Hiβ Ala Phe Arg Arg He Gly Leu Aβn 1745 1750 1755 1760

Ser Ser Ala Cyβ Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cyβ Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Aβn Lys Cys Phe 1795 1800 1805

Tyr Asn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu Hiβ Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lye Val Leu Phe Aβn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Aβp Cys Phe Asn Phe He Val Ser Asn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He His Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser Tyr 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Aβn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lys Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly Hiβ He Leu Ser He Lye Gin Leu Ser Cyβ 1985 1990 1995 2000

He Gin Ala He Val Gly Aβp Ala Val Ser Arg Gly Gly He Aβn Pro 2005 2010 2015

He Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His Hiβ Aβp 2035 2040 2045

Val Ala Ser Gly Gin Aβp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly His He Leu Leu Tyr Ser Gly 2100 2105 2110

Asn Arg Lys Leu He Asn Arg Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Asp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr He Lys Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID Nθ:7:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid (C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 7:

ACCAAACAAA GTTGGGTAAG GATAGATCAA TCAATGATCA TATTCTAGTA CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TGAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATTCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTA CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATCAGGCTG TTAGAGGTTG 420

TTCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAAGCAG TAGTGATCAA TCCAGGTCCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGATCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATTCTA GCCCAGATCT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC TTTACGCCGA TTCATGGTGG CTCTAATCCT GGATATCAAG AGGACACCCG 840

GGAACAAACC TAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCTTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAT CTTTACCAGC 1020

AAATGGGAGA AACTGCACCC TACATGGTAA TCCTAGAGAA CTCAATTCAG AACAAGTTCA 1080

GCGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGTCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTGAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCCGAACTCG 1260 GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320

GGATCAGTAG AGCGGTCGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCAGGA TTGGGGGGCA AGGAAGACAG GAGGGTCAAA CAGAGTCGGG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG AGTCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCCTCC AACCAGCATG CCCCTAGACA TTGACACTGC ATCGGAGTCA GGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCTC TGCTCAGGCT GCAAGCCATG GCAGGAATCT 1620

TGGAAGAACA AGGCTCAGAC ACGGACACCC CTAGGGTATA CAATGACAGA GATCTTCTAG 1680

ATTAGGTGCG AGAGGCCGAG GACCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCAACCA ACCATCCACT CCCACGACTG 1800

GAGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC GTCGAGGAAG CCATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ATCCAGGACA GGACCGAGCC GCCTGCAAGG AAGAGGAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCTT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GATCTGGAGA AAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCTCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATCATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CGATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAA ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGAACCCC 2460

AGTAGGGCCA GCACTTCCGA GACACCCATT AAAAAGGGGA CAGACGCGAG ATTGGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CGTCAGGGCC AGATGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCCGATGT CCAAGACATC 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820 TTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TTGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAACTCAATC CCGACCTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AGCCCGTTGC CAGCCGACAA 3060

CTCCAGGGAA TGACTAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAA 3120

CTAAAGCCGA TCGGGAAAAA GGTGAGCTCA GCCGTCGGGT TTGTCCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGT TGACTCTCCT TGATGATATC AAAGGAGCCA ACGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360

CCAGTCGACC TAATTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCTAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCTACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGTGATA GGAAGGATGA ATGCTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGAGATCCCC TAGGGCCTCC AATCGGGCGA GCATTCGGGT 3660

CCCTGCCCTT AGGTGTTGGT AGATCCACAG CAAAACCCGA GGAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACCCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAATGCAAA CCAAGTGTGC AATGCGGTTA ATCTAATACC GCTGGACACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCCA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTA GTGACCCTCA 4020

GGATTGACAA GGCGATTGGC CCTGGGAAGA TCATCGACAA TGCAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCACTGA TGGATATCAA TGAAGACCTT AATCGGTTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380 AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATACCCGAA AACGACCCCC CTCATAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCAAAAGAC TTCACGGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACAGCA AGTGTGGACA CCAGGCGGCC CAAGCACAGA ACAGCCCCGA CACAAGGCCA 4620

CCACCAGCCA TCCCAATCCG CGTCCTCCTC GTAGGACCCC CGAGGACCAA CCCCCAAGGT 4680

CGCTCCGGAC ACAGACCACC AGCCGCATCC CCACAGCCCT CGGGAAAGGA ACCCCCAGCA 4740

ACTGGAAGGC CCCTTCCCCC CTCCCCCAAC GCAAGAACCC CACAACCGAA CCGCACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGACCCTCCC TCCCCGGCAT 4860

ACTAAACAAA ACTTAGGGCC AAGGAACACA CACACCCGAC AGAACCCAGA CCCCGGCCCG 4920

CGGCACCGCG CCCCCACCCC CCGAAAACCA GAGGGAGCCC CCAACCAATC CCGCCGCCCC 4980

CCCCGGTGCC CACAGGTAGG CACACCAACC CCCGAACAGA CCCAGCACCC AGCCACCGAC 5040

AATCCAAGAC GGGGGGCCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCATCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAGCCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGAAAAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGGCC CGATCCGGCG GGAAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

TGGGGGACCC CCAAACCGCA AAAGACATCA GTATCCCACC GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCTCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CATCCGACGA CACTCAATTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAATGTCTT TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGGAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTGG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAAATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTTGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCAAGCCTGG AAACTACTAA TCAGGCAATT 5940 GAGGCAATCA GGCAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTAGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCCATC CAGGCTTTGA GCTATGCGCT TGGGGGAGAT 6180

ATCAATAAGG TATTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ATATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TCCACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTCT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTGGTCGAGG TGAACGGTGT GACCATCCAA GTCGGGAGCA GGAGGTATCC GGACGCGGTG 6780

TACCTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAAGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGCTGGAG GATGCCAAGG AATTGCTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTTTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GGGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACAGGG 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCCCTACAA CTCTTGAAAC ACAGATTTCC 7140

CACAAGTCTC CTCTCCGTCA TCAAGCAACC ACCGCATCCA GCATCAAGGC CACCCGAAAT 7200

TGTCTCCGGC TTCCCTCTGG CCGAACGATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7 60

ATCATCCACA ATGTCACCAC ACCGAGACCG AATAAATGCC TTCTACAAAG ACAACCCCCA 7320

TCCTAAG6GA AGTAGGATAG TTATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTATTCG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTC CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAGAGCC TCAGCACCAA 7500 TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

GATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

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CATCTCTGAC AAAATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAACTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGG CCAGGGCAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTGGA CTTGTATTTA AGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACCATGACAT CCCAGGGAAT GTACGGGGGA ACTTACCTAG TGGGAAAGCC 7980

TAATCTGAGC AGTAAAGGGT CAGAGTTGTC ACAACTGAGC ATGCACCGAG TGTTTGAAGT 8040

AGGGGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATTTTGA 8100

GCAACCAGTC AGTAATGATT TCAGCAACTG CATGGTGGCT TTGGGGGAGC TCAGGTTCGC 8160

AGCCCTCTGT CACAGGGAAG ATTCTGTCAC GGTTCCCTAT CAGGGGTCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCCTATCA ACGGATGATC CAGTGATAGA TAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGGACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAGC AGGCGTGTAA GGGTAAAAAC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTAATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCAGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAAACCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC AACCTCTTCA CTGTTCCAAT CAAGGAAGCA GGCGAGGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTAATTCT 8820

ACCTGGTCAG GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TATGTTTACA GCCCAGGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCAA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA TTCAGAATCT GGTGGACATA TCACTCACTC 9060 TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACTCGG GAAGATGGAA CCAATCGCAG 9120

ATAGGGCTGC CAGTGAACCG ATCACATGAT GTCACTCAGA CACCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTTCCC GTCATGGACT 9240

CGCTATCTGT CAACCAGATC TTGTACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ATAAGATAGT AGCTATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTTGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTCTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540

CAAGGAAGAT CCGTGAGCTC CTAAAAAAGG GAAATTCGCT GTACTCCAAA GTCAGTGATA 9600

AGGTTTTCCA ATGCCTGAGG GACACTAACT CACGGCTTGG CCTAGGCTCC GAATTGAGGG 9660

AGGACATCAA GGAGAAAATT ATTAACTTGG GAGTTTACAT GCACAGCTCC CAATGGTTTG 9720

AGCCCTTTCT GTTTTGGTTT ACAGTCAAGA CTGAGATGAG GTCAGTGATT AAATCACAAA 9780

CCCATACTTG CCATAGGAGG AGACACACAC CTGTATTCTT CACTGGTAGT TCAGTTGAGC 9840

TGTTAATCTC TCGTGACCTT GTTGCTATAA TCAGTAAGGA GTCTCAACAT GTATATTACC 9900

TGACGTTTGA ACTGGTTTTG ATGTATTGTG ATGTCATAGA GGGGAGGTTA ATGACAGAGA 9960

CCGCTATGAC CATTGATGCT AGGTATGCAG AACTTCTAGG AAGAGTCAGA TACATGTGGA 10020

AACTGATAGA TGGTTTCTTC CCTGCACTCG GGAATCCAAC TTATCAAATT GTAGCTATGC 10080

TGGAGCCACT TTCACTTGCT TACCTGCAAC TGAGGGACAT AACAGTAGAA CTCAGAGGTG 10140

CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGATGTTCT TGACCAAAAC GGGTTTTCTG 10200

ATGAAGGTAC TTATCATGAG TTAATTGAAG CCTTAGATTA CATTTTCATA ACTGATGACA 10260

TACATCTGAC AGGGGAGATT TTCTCATTTT TCAGAAGTTT CGGCCACCCC AGACTTGAAG 10320

CAGTAACGGC TGCTGAAAAT GTCAGGAAAT ACATGAATCA GCCTAAAGTC ATTGTGTATG 10380

AGACTCTGAT GAAGGGTCAT GCCATATTTT GTGGAATCAT AATCAACGGC TATCGTGACA 10440

GGCACGGAGG CAGTTGGCCA CCCCTGACCC TCCCCCTGCA TGCTGCAGAC ACAATCCGGA 10500

ATGCTCAAGC TTCAGGTGAA GGGTTAACAC ATGAGCAGTG CGTTGATAAC TGGAGATCAT 10560

TTGCTGGAGT GAGATTTGGC TGTTTTATGC CTCTTAGCCT GGACAGTGAT CTGACAATGT 10620 CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGCGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTAA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGGT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGAGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTA GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTTAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCTAGAGCC CTAAGAAGCC 12660

ATATGTGGGC AAGACTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTA GATCCTTGCG ATCTGCCGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CAAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCGACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCAG AGTGGCAAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA AGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACTGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTCT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTTATAGAG CCAAGATTAT 13680

TCACCATCTA CTTGGGCCAG TGTGCAGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740 GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCTTC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTTGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTTTTGT GTGAAAGCGA TGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTGT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCGATTCGA GGTCTAAGGC CGGTAGAGAA ATGTGCAGTT CTAACCGATC 14160

ATATCAAGGC AGAGGCTAGG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGTCG AGGATCTATC AAACAGATAA 14280

GATTGAGAGT TGATCCAGGA TTCATTTTTG ATGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGGTCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGATTTCAGA CCTCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGTAGTCT TGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTA AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAAG 14580

ACGGCTTGTT CTTGGGTGAG GGGTCGGGTT CTATGTTGAT CACTTATAAG GAGATACTAA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAGGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT ATAGATTGCT 14820

TCAATTTCAT AGTCAGTAAT ATCCCTACCT CTAGTGTGGG ATTTATCCAT TCAGATATAG 14880

AGACCTTACC CAACAAAGAT ACTATAGAGA AGTTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTACT CCTTGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGCTATG TAGGGTCTCA TTATAGAGAA GTGAACCTTG 15060

TCTACCCTAG GTACAGCAAC TTCATATCTA CTGAATCTTA TTTAGTTATG ACAGATCTCA 15120

AAGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGC 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCTATCAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGGCGCAGTT AGTAGAGGTG ATATCAACCC TATTCTGAAA AAACTTACAC 15300 CTATAGAGCA GGTGCTGATC AGTTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360

AATTAATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAACTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGTAGGCAAC GAGAACTTGT ATCTAGGATC ACTCGCAAAT 15540

TTTGGGGGCA TATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATCGG TTTATCCAGA 15600

ATCTCAAGTC CGGTTATCTA ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTAAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGCGCT CTGATTAAGG 15780

ATTAATTGGT TGAACTCCGG AACCCTAATC CTACCCTAGG TAGTTAGGCA TTATTTGCAA 15840

TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894 (2) INFORMATION FOR SEQ ID NO: 8:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 8:

Met Aβp Ser Leu Ser Val Aβn Gin He Leu Tyr Pro Glu Val Hiβ Leu 1 5 10 15

Asp Ser Pro He Val Thr Asn Lys He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Aβp Pro Thr Leu Cyβ Gin Aβn 35 40 45

He Lye Hiβ Arg Leu Lye Asn Gly Phe Ser Asn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser Hiβ He Pro Tyr Pro Aβn Cys Asn Gin Asp Leu Phe Asn 85 90 95 He Glu Asp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lye Glu Lye He He Aβn Leu Gly Val Tyr Met His Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cyβ His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Aβp Ala Arg Tyr Ala Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lye Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr G n He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cys Phe Thr Glu He His Asp Val Leu Asp Gin Aβn Gly 305 310 315 320

Phe Ser Aβp Glu Gly Thr Tyr Hiβ Glu Leu He Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Asp Asp He Hiβ Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly Hiβ Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365 Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lye Gly Hiβ Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cys Val Asp Aβn Trp Arg Ser Phe Ala Gly Val Arg Phe 435 440 445

Gly Cys Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 450 455 460

Lys Aβp Lye Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lye Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Aβp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Asp 500 505 510

Met He Met Tyr Val Val Ser Gly Ala Tyr Leu His Aβp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lye Glu He Lye Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lye Met Thr Tyr Lye Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Asn Gly 565 570 575

Met Ala Lys Asp Glu Hiβ Aβp Leu Thr Lye Ala Leu Hie Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lye Aβp Leu Lye Glu Ser Hiβ Arg Gly Gly Pro 595 600 605

Val Leu Lye Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Asn 610 615 620

Val Lys Ala Glu Lys Gly Phe Val Gly Phe Pro His Val He Arg Gin 625 630 635 640

Asn Gin Asp Thr Asp His Pro Glu Aβn He Glu Thr Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu Hiβ Lye Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cys Pro Pro Aβp Leu Asp Ala His Val 705 710 715 720

Pro Leu Cys Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lys Lys Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Aβp Tyr Phe Val He Leu Arg Gin Arg Leu Hiβ Aβp He Gly Hiβ 805 810 815

Hiβ Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830

Ser Lys Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cyβ Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Aβn Ser Thr Met 900 905 910

Thr Arg Aβp Val Val He Pro Leu Leu Thr Aβn Aβn Asp Leu Leu He 915 920 925 Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Aβp Leu Lye Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu Hiβ Gin Val Met Thr Gin Gin Pro Gly Aβp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Aβp Pro Tyr Ser Ala Aβn Leu Val Cyβ Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lye Asn He Thr Ala Arg Phe Val Leu He Hiβ 1010 1015 1020

Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Asp Asp Ser Lys Glu 1025 1030 1035 1040

Glu Asp Glu Arg Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Asp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lys Arg Asn Val Leu He Asp Lys Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg His Glu Thr Cys Val He Cys Glu Cyβ Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Asp 1185 1190 1195 1200 He Asp Lys Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Aβp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Asp Asp Asp Ser Ser Trp Asn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Asn Leu Ala His Arg Leu Arg Asp Arg Ser Thr Gin 1285 1290 1295

Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lye Lye Val Aβp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu His Val Glu Thr Asp Cys Cys Val He Pro Met He Aβp 1365 1370 1375

Hiβ Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu He Tyr Asp Aβn Ala Pro Leu He Aβp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser Hiβ Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Aβp Leu Val Thr Lys Phe Glu Lys Asp Hiβ Met 1445 1450 1455

Aβn Glu He Ser Ala Leu He Gly Aβp Aβp Aβp He Aβn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Asn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lye Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp Hiβ Cyβ. Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Asn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565

Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cyβ Glu Ser Asp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Asn He Gin Ala Lye His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cyβ Gin Pro Gly Thr Cyβ Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lye Cyβ Ala Val Leu Thr Aβp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Asn He Asn Pro He He Val 1650 1655 1660

Asp His Tyr Ser Cyβ Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Aβp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys Val Gly Ser Asn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Asp Phe Arg Pro Pro His Asp Asp Val Ala Lys Leu 1715 1720 1725

Leu Lys Asp He Asn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Ser Leu Ala Asn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Aβn 1745 1750 1755 1760 Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cyβ Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cys Phe 1795 1800 1805

Tyr Asn Ser Gly Val Ser Ala Aβn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser He Aβp Cyβ Phe Aβn Phe He Val Ser Aβn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He Hie Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lye Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Asn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lys Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Gly Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

He Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Ser Cys Gly 2020 2025 2030 Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His His Asp 2035 2040 2045

Val Ala Ser Gly Gin Asp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe Hiβ Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu Val 2085 2090 2095

Ser Arg He Thr Arg Lye Phe Trp Gly Hiβ He Leu Leu Tyr Ser Gly 2100 2105 2110

Asn Arg Lys Leu He Asn Arg Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Aβp Leu Hiβ Gin Aβn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lye Val Thr Val Lye Glu Thr Lye Glu Trp Tyr Lye Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid (C> STRANDEDNESS : single (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 9:

ACCAAACAAA GTTGGGTAAG GATAGTTCAA TCAATGATCA TCTTCTAGTG CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240 TTACCACTCG ATCCAGACTT CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAATTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCCCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TGGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GAAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAC CTTTACCAGC 1020

AAATGGGGGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 11 0

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTAAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260

GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320

AGATCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCGAGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGAG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGCCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCTTCC AACCGGCACA CCCCTAGACA TTGACACTGC AACGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTTAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTATAGTGTA CAATGACAGA AATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GGCCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCATCA ACCATCCACT CCCACGATTG 1800 GAGCCAATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC ACCTGCAGGG AAGAGAAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GACCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCCCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTACG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGGACCCC 2460

GGTAGGGCCA GCACTTCCGG GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ATGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360 CCAGTCGACC CAACTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGACCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCCACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATTCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CCCTGCCCTT AGGTGTTGGC AGATCCACAG CAAAGCCCGA AAAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTCGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATAGGC CCTGGGAAGA TCATCGACAA TACAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCGCTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380

AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATGCCCGAA AACGACCCCC CTCACAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCGAAAGAC TCCACGGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACGGCA AGCGCGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCCGA CACAAGGCCA 4620

CCACCAGCCA CCCCAATCTG CATCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGC 4680

TGCCCCCGAT CCAAACCACC AACCGCATCC CCACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ATTGGAAGGC CCCTCCCCCT CTTCCTCAAC ACAAGAACTC CACAACCGAA CCGCACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC TCCCCGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGCCCA 4920 CGGCGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG GACACCAACC CCCGAACAGA CCCAGCACCC AACCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGCCC CGATCCGGCG GGGAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACACCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCTCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAACTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940

GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGTTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAC 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 62 0

AGCGGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480 GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TACACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GATCATCCAA GTCGGGAGCA GGAGGTATCC AGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTCTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACGGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCACCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TCATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTTG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTAGA CTTGTATTTA GGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGCAAAAGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040 AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATCTTGA 8100

GCAACCAGTC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCTTATCA ACGGATGATC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAAC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTGATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAATCCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC TACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACATA TCACTCACTC 9060

TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATCGCAG 9120

ATAGGGCTGC TAGTGAACCA ATCACATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240

CGCTATCTGT CAACCAGATC TTATACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ATAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540

CGAGGAAGAT CCGTGAACTC CTCAAAAAGG GGAATTCGCT GTACTCCAAA GTCAGTGATA 9600 ACACTGATCA TCCGGAGAAT ATGGAAGCTT ACGAGACAGT CAGTGCATTT ATCACGACTG 11220

ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT CAGCTTGTTT GCACAGAGGC 11280

TAAATGAGAT TTACGGATTG CCCTCATTTT TCCAGTGGCT GCATAAGAGG CTTGAGACCT 11340

CTGTCCTGTA TGTAAGTGAC CCTCATTGCC CCCCCGACCT TGACGCCCAT ATCCCGTTAT 11400

ATAAAGTCCC CAATGATCAA ATCTTCATTA AGTACCCTAT GGGAGGTATA GAAGGGTATT 11460

GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATCTATA CCTGGCTGCT TATGAGAGCG 11520

GAGTAAGGAT TGCTTCGTTA GTGCAAGGGG ACAATCAGAC CATAGCCGTA ACAAAAAGGG 11580

TACCCAGCAC ATGGCCCTAC AACCTTAAGA AACGGGAAGC TGCTAGAGTA ACTAGAGATT 11640

ACTTTGTAAT TCTTAGGCAA AGGCTACATG ATATTGGCCA TCACCTCAAG GCAAATGAGA 11700

CAATTGTTTC ATCACATTTT TTTGTCTATT CAAAAGGAAT ATATTATGAT GGGCTACTTG 11760

TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG GTCAGAGACT ATAGTTGATG 11820

AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC TAAAAGCATC GAGAGAGGTT 11880

ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT GATACAGCAA ATTCTGATCT 11940

CTCTTGGCTT CACAATCAAT TCAACCATGA CCCGGGATGT AGTCATACCC CTCCTCACAA 12000

ACAACGACCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TATTGGGGGG ATGAATTATC 12060

TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC AGTAACATCA TCAATTGCTG 12120

ATCTCAAGAG AATGATTCTC GCCTCACTAA TGCCTGAAGA GACCCTCCAT CAAGTAATGA 12180

CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTG GATACCACAA 12480

AAGGCTTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGC 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCT CTAAGAAGCC 12660

ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720 TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CTAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCGAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTCATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTCTTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTAT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 14160

ATATCAAGGC AGAGGCTATG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280 GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGCTTTCAGA CCCCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAGG 14580

ACGGCTTGTT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAG GAGATACTTA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820

TCAATTTCAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTGCC TGACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTCA TTATAGAGAA GTGAACCTTG 15060

TATACCCTAG ATACAGCAAC TTCATCTCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120

AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGA 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TCTGGGGGCA CATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGCTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ACTAATTGGT TGAACTCCGG AACCCTAATC CTGCCCTAGG TGGTTAGGCA TTATTTGCAA 15840 TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894

(2) INFORMATION FOR SEQ ID NO: 10:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 10:

Met Aβp Ser Leu Ser Val Asn Gin He Leu Tyr Pro Glu Val His Leu 1 5 10 15

Aβp Ser Pro He Val Thr Aβn Lys He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Aβn 35 40 45

He Lys His Arg Leu Lys Asn Gly Phe Ser Aβn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser Hiβ He Pro Tyr Pro Asn Cyβ Asn Gin Asp Leu Phe Aβn 85 90 95

He Glu Aβp Lye Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gin Cys Leu 115 120 125

Arg Aβp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lye Glu Lye Val He Aβn Leu Gly Val Tyr Met Hiβ Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr Hiβ Thr Cys His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Aβp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lye Leu He Aβp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cys Phe Thr Glu He His Asp Val Leu Asp Gin Asn Gly 305 310 315 320

Phe Ser Aβp Glu Gly Thr Tyr Hiβ Glu Leu He Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Asp Aβp He His Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Aβp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Aβp Thr He Arg Aβn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

Hiβ Glu Gin Cyβ Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lye Phe 435 440 445

Gly Cyβ Phe Met Pro Leu Ser Leu Aβp Ser Asp Leu Thr Met Tyr Leu 450 455 460 Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Aβp Pro Tyr Asp 500 505 510

Val He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Aβn Leu He Ser Aβn Gly He Gly Lye Tyr Phe Lye Aβp Aβn Gly 565 570 575

Met Ala Lye Aβp Glu Hiβ Aβp Leu Thr Lys Ala Leu His Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lys Asp Leu Lye Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Asn 610 615 620

Val Arg Ala Ala Lys Gly Phe He Gly Phe Pro Gin Val He Arg Gin 625 630 635 640

Asp Gin Asp Thr Asp His Pro Glu Asn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lys Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cys Pro Pro Asp Leu Asp Ala Hie He 705 710 715 720

Pro Leu Tyr Lye Val Pro Aβn Aβp Gin He Phe He Lys Tyr Pro Met 725 730 735 Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lye Lye Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Asp Tyr Phe Val He Leu Arg Gin Arg Leu His Asp He Gly Hiβ 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830

Ser Lys Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Aβp Val Val He Pro Leu Leu Thr Aβn Aβn Asp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Aβn 930 935 940

Met Ser Arg Leu Phe Val Arg Aβn He Gly Aβp Pro Val Thr Ser Ser 945 950 955 960

He Ala Aβp Leu Lys Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu Hiβ Gin Val Met Thr Gin Gin Pro Gly Aβp Ser Ser Phe Leu 980 985 990

Aβp Trp Ala Ser Aβp Pro Tyr Ser Ala Aβn Leu Val Cyβ Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Asn He Thr Ala Arg Phe Val Leu He His 1010 1015 1020

Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Aβp Aβp Ser Lye Glu 1025 1030 1035 1040

Glu Aβp Glu Gly Leu Ala Ala Phe Leu Met Aβp Arg Hiβ He He Val 1045 1050 1055

Pro Arg Ala Ala Hiβ Glu He Leu Aβp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Aβp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lye Arg Asn Val Leu He Asp Lys Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser Hiβ Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg His Glu Thr Cys Val He Cys Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Asp 1185 1190 1195 1200

He Asp Lys Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Asp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Asp Aβp Asp Ser Ser Trp Aβn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Aen Leu Ala His Arg Leu Arg Aβp Arg Ser Thr Gin 1285 1290 1295 Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Aβp Lye Lye Val Aβp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lye Aβp Thr Gly Ser Ser Aβn Thr Val 1345 1350 1355 1360

Leu Hiβ Leu His Val Glu Thr Asp Cys Cys Val He Pro Met He Asp 1365 1370 1375

His Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cyβ Thr Aβn Pro Leu He Tyr Aβp Aβn Ala Pro Leu He Aβp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser Hiβ Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Asp Leu Val Thr Lye Phe Glu Lys Asp His Met 1445 1450 1455

Asn Glu He Ser Ala Leu He Gly Aβp Asp Asp He Aβn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Aβn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Aβp Ala Gin Asn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565 Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Aβp Glu Aβp Val Val 1585 1590 1595 1600

Pro Aβp Arg Phe Aβp Aβn He Gin Ala Lye His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cyβ Ala Val Leu Thr Asp His He Lye Ala Glu Ala 1635 1640 1645

Met Leu Ser Pro Ala Gly Ser Ser Trp Aβn He Aβn Pro He He Val 1650 1655 1660

Aβp His Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Aβp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Aβn 1700 1705 1710

Met Ser He Lys Ala Phe Arg Pro Pro His Asp Aβp Val Ala Lye Leu 1715 1720 1725

Leu Lye Aβp He Aβn Thr Ser Lye His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Asn Leu Ala Asn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760

Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cys Phe 1795 1800 1805

Tyr Asn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Asp Cys Phe Asn Phe He Val Ser Asn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He His Ser Asp He Glu Thr Leu Pro Asp Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Asn Arg Leu Met 1955 1960 1965

Aβn Pro Glu Lye He Lye Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Asp Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

Thr Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His Hiβ Asp 2035 2040 2045

Val Ala Ser Gly Gin Asp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Aβn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lye Phe Trp Gly Hiβ He Leu Leu Tyr Ser Gly 2100 2105 2110

Aβn Arg Lys Leu He Asn Lys Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125 Leu He Leu Asp Leu Hiβ Gin Aβn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr Val Lys Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 11:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 11:

ACCAAACAAA GTTGGGTAAG GATAGTTCAA TCAATGATCA TCTTCTAGTG CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTT CTGGACCGGT TGGTGAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAATTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGG GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCCCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720 TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GAAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAC CTTTACCAGC 1020

AAATGGGGGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTAAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260

GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320

AGATCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCGAGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGAG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGCCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCTTCC AACCGGCACA CCCCTAGACA TTGACACTGC AACGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTTAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTATAGTGTA CAATGACAGA AATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GGCCAGAACA ACATCCGCCT ACCATCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCATCA ACCATCCACT CCCACGATTG 1800

GAGCCAATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC ACCTGCAGGG AAGAGAAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GACCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCCCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTACG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280 GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGGACCCC 2460

GGTAGGGCCA GCACTTCCGG GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ATGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360

CCAGTCGACC CAACTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG GTCCACAATG ACAGAGACCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3 80

AAGGGTCGAT CGCTCCGATA CAACCCACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATTCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

TCCTGCCCTT AGGTGTTGGC AGATCCACAG CAAAGCCCGA AAAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840 TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTCGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATAGGC CCTGGGAAGA TCATCGACAA TACAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCGCTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380

AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATGCCCGAA AACGACCCCC CTCACAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCGAAAGAC TCCACGGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACGGCA AGCGCGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCTGA CACAAGGCCA 4620

CCACCAGCCA CCCCAATCTG CATCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGC 4680

TGCCCCCGAT CCAAACCACC AACCGCATCC CCACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ATTGGAAGGC CCCTCCCCCT CTTCCTCAAC ACAAGAACTC CACAACCGAA CCGCACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC TCCCCGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGTCCA 4920

CGGTGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG GACACCAACC CCCGAACAGA CCCAGCACCC AACCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGCCC CGATCCGGCG GGGAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCTCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAACTC 5400 CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940

GAGACAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGTTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAC 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCGGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TACACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGAGGTATCC AGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTCTACAT CCTGATTGCA 6960 GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACGGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCACCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATCAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TCATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTTG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

AATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTAGA CTTGTATTTA GGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGCAAAAGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATCTTGA 8100

GCAACCAGTC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCTTATCA ACGGATGATC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAAC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTGATCT 8520 GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAATCCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC TACCTCTTCA CTGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACATA TCACTCACTC 9060

TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATCGCAG 9120

ATAGGGCTGC TAGTGAACCA ATCACATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240

CGCTATCTGT CAACCAGATC TTATACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ATAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540

CGAGGAAGAT CCGTGAACTC CTCAAAAAGG GGAATTCGCT GTACTCCAAA GTCAGTGATA 9600

AGGTTTTCCA ATGCTTAAGG GACACTAACT CACGGCTTGG CCTAGGCTCC GAATTGAGGG 9660

AGGACATCAA GGAGAAAGTT ATTAACTTGG GAGTTTACAT GCACAGCTCC CAGTGGTTTG 9720

AGCCCTTTCT GTTTTGGTTT ACAGTCAAGA CTGAGATGAG GTCAGTGATT AAATCACAAA 9780

CCCATACTTG CCATAGGAGG AGACACACAC CTGTATTCTT CACTGGTAGT TCAGTTGAGT 9840

TGCTAATCTC TCGTGACCTT GTTGCTATAA TCAGTAAAGA GTCTCAACAT GTATATTACC 9900

TGACATTTGA ACTGGTTTTG ATGTATTGTG ATGTCATAGA GGGGAGGTTA ATGACAGAGA 9960

CCGCTATGAC TATTGATGCT AGGTATACAG AGCTTCTAGG AAGAGTCAGA TACATGTGGA 10020

AACTGATAGA TGGTTTCTTC CCTGCACTCG GGAATCCAAC TTATCAAATT GTAGCCATGC 10080 TGGAGCCTCT TTCACTTGCT TACCTGCAGC TGAGGGATAT AACAGTAGAA CTCAGAGGTG 10140

CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGATGTTCT TGACCAAAAC GGGTTTTCTG 10200

ATGAAGGTAC TTATCATGAG TTAACTGAAG CTCTAGATTA CATTTTCATA ACTGATGACA 10260

TACATCTGAC AGGGGAGATT TTCTCATTTT TCAGAAGTTT CGGCCACCCC AGACTTGAAG 10320

CAGTAACGGC TGCTGAAAAT GTTAGGAAAT ACATGAATCA GCCTAAAGTC ATTGTGTATG 10380

AGACTCTGAT GAAAGGTCAT GCCATATTTT GTGGAATCAT AATCAACGGC TATCGTGACA 10440

GGCACGGAGG CAGTTGGCCA CCGCTGACCC TCCCCCTGCA TGCTGCAGAC ACAATCCGGA 10500

ATGCTCAAGC TTCAGGTGAA GGGTTAACAC ATGAGCAGTG CGTTGATAAC TGGAAATCTT 10560

TTGCTGGAGT GAAATTTGGC TGCTTTATGC CTCTTAGCCT GGATAGTGAT CTGACAATGT 10620

ACCTAAAGGA CAAGGCACTT GCTGCTCTCC AAAGGGAATG GGATTCAGTT TACCCGAAAG 10680

AGTTCCTGCG TTACGACCCT CCCAAGGGAA CCGGGTCACG GAGGCTTGTA GATGTTTTCC 10740

TTAATGATTC GAGCTTTGAC CCATATGATG TGATAATGTA TGTTGTAAGT GGAGCTTACC 10800

TCCATGACCC TGAGTTCAAC CTGTCTTACA GCCTGAAAGA AAAGGAGATC AAGGAAACAG 10860

GTAGACTTTT TGCTAAAATG ACTTACAAAA TGAGGGCATG CCAAGTGATT GCTGAAAATC 10920

TAATCTCAAA CGGGATTGGC AAATATTTTA AGGACAATGG GATGGCCAAG GATGAGCACG 10980

ATTTGACTAA GGCACTCCAC ACTCTAGCTG TCTCAGGAGT CCCCAAAGAT CTCAAAGAAA 11040

GTCACAGGGG GGGGCCAGTC TTAAAAACCT ACTCCCGAAG CCCAGTCCAC ACAAGTACCA 11100

GGAACGTGAG AGCAGCAAAA GGGTTTATAG GGTTCCCTCA AGTAATTCGG CAGGACCAAG 11160

ACACTGATCA TCCGGAGAAT ATGGAAGCTT ACGAGACAGT CAGTGCATTT ATCACGACTG 11220

ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT CAGCTTGTTT GCACAGAGGC 11280

TAAATGAGAT TTACGGATTG CCCTCATTTT TCCAGTGGCT GCATAAGAGG CTTGAGACCT 11340

CTGTCCTGTA TGTAAGTGAC CCTCATTGCC CCCCCGACCT TGACGCCCAT ATCCCGTTAT 11400

ATAAAGTCCC CAATGATCAA ATCTTCATTA AGTACCCTAT GGGAGGTATA GAAGGGTATT 11460

GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATCTATA CCTGGCTGCT TATGAGAGCG 11520

GAGTAAGGAT TGCTTCGTTA GTGCAAGGGG ACAATCAGAC CATAGCCGTA ACAAAAAGGG 11580

TACCCAGCAC ATGGCCCTAC AACCTTAAGA AACGGGAAGC TGCTAGAGTA ACTAGAGATT 11640 ACTTTGTAAT TCTTAGGCAA AGGCTACATG ATATTGGCCA TCACCTCAAG GCAAATGAGA 11700

CAATTGTTTC ATCACATTTT TTTGTCTATT CAAAAGGAAT ATATTATGAT GGGCTACTTG 11760

TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG GTCAGAGACT ATAGTTGATG 11820

AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC TAAAAGCATC GAGAGAGGTT 11880

ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT GATACAGCAA ATTCTGATCT 11940

CTCTTGGCTT CACAATCAAT TCAACCATGA CCCGGGATGT AGTCATACCC CTCCTCACAA 12000

ACAACGACCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TATTGGGGGG ATGAATTATC 12060

TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC AGTAACATCA TCAATTGCTG 12120

ATCTCAAGAG AATGATTCTC GCCTCACTAA TGCCTGAAGA GACCCTCCAT CAAGTAATGA 12180

CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTG GATACCACAA 12480

AAGGCTTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCT CTAAGAAGCC 12660

ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CTAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCGAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200 CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATGCA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTCATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTCTTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTAT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGACCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 1 160

ATATCAAGGC AGAGGCTATG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220

TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280

GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGCTTTCAGA CCCCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAGG 14580

ACGGCTTGTT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAA GAGATACTTA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760 TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820

TCAATTTCAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTGCC TGACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTCA TTATAGAGAA GTGAACCTTG 15060

TATACCCTAG ATACAGCAAC TTCATCTCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120

AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGA 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TCTGGGGGCA CATTCTTCTT TACTCCGGGA ACAAAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGCTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ACTAATTGGT TGAACTCCGG AACCCTAATC CTGCCCTAGG TGGTTAGGCA TTATTTGCAA 15840

TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894 (2) INFORMATION FOR SEQ ID NO: 12:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 12: Met Asp Ser Leu Ser Val Asn Gin He Leu Tyr Pro Glu Val His Leu 1 5 10 15

Aβp Ser Pro He Val Thr Aβn Lyε He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Asn 35 40 45

He Lys His Arg Leu Lye Aβn Gly Phe Ser Aβn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser Hiβ He Pro Tyr Pro Aβn Cyβ Aβn Gin Aβp Leu Phe Aβn 85 90 95

He Glu Aβp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lye Lye 100 105 110

Gly Aβn Ser Leu Tyr Ser Lye Val Ser Aβp Lye Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Aβn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Aβp 130 135 140

He Lye Glu Lys Val He Aβn Leu Gly Val Tyr Met Hiβ Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cys His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin Hiβ Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Asp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lys Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270 Gly Aβn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cyβ Phe Thr Glu He Hiβ Aβp Val Leu Aβp Gin Aβn Gly 305 310 315 320

Phe Ser Aβp Glu Gly Thr Tyr Hiβ Glu Leu Thr Glu Ala Leu Aβp Tyr 325 330 335

He Phe He Thr Aβp Aβp He Hiβ Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu Hiβ 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cys Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lye Phe 435 440 445

Gly Cyβ Phe Met Pro Leu Ser Leu Asp Ser Aβp Leu Thr Met Tyr Leu 450 455 460

Lys Aβp Lye Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Asp 500 505 510

Val He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Asn Gly 565 570 575

Met Ala Lys Asp Glu His Asp Leu Thr Lye Ala Leu Hiβ Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lye Asp Leu Lys Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Aβn 610 615 620

Val Arg Ala Ala Lye Gly Phe He Gly Phe Pro Gin Val He Arg Gin 625 630 635 640

Asp Gin Asp Thr Aβp Hiβ Pro Glu Asn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lys Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cys Pro Pro Asp Leu Asp Ala His He 705 710 715 720

Pro Leu Tyr Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Aβn Leu Lye Lye Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Aβp Tyr Phe Val He Leu Arg Gin Arg Leu Hiβ Asp He Gly His 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser His Phe Phe Val Tyr 820 825 830 Ser Lys Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Asp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Asp Val Val He Pro Leu Leu Thr Asn Asn Aβp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Aβn Tyr Leu Aβn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lye Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cys Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Asn He Thr Ala Arg Phe Val Leu He Hiβ 1010 1015 1020

Ser Pro Aβn Pro Met Leu Lye Gly Leu Phe Hie Asp Asp Ser Lye Glu 1025 1030 1035 1040

Glu Asp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Asp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100 Aβn Tyr Aβp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lye Arg Asn Val Leu He Aβp Lye Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg His Glu Thr Cys Val He Cys Glu Cyβ Gly Ser 1170 1175 1180

Val Aβn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Aβp 1185 1190 1195 1200

He Aβp Lye Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Aβp Glu Arg Thr Aβp Met Lye Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Aβp Aβp Aβp Ser Ser Trp Aβn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Aβn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Aβn Leu Ala Hiβ Arg Leu Arg Asp Arg Ser Thr Gin 1285 1290 1295

Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lys Lys Val Asp 1315 1320 1325

Thr Aβn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu His Val Glu Thr Asp Cys Cys Val He Pro Met He Asp 1365 1370 1375

Hiβ Pro Arg He Pro Ser Ser Arg Lye Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu He Tyr Asp Asn Ala Pro Leu He Asp Arg Asp 1395 1400 1405

Ala Thr Arg Leu Tyr Thr Gin Ser His Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Asp Leu Val Thr Lye Phe Glu Lys Aβp Hiβ Met 1445 1450 1455

Aβn Glu He Ser Ala Leu He Gly Asp Asp Aβp He Aβn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cyβ Ala Ala He Asn Trp Ala Phe Asp Val His Tyr Hiβ Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Asn Leu Hiβ Thr Thr Val Cyβ Aβn Met 1555 1560 1565

Val Tyr Thr Cyβ Tyr Met Thr Tyr Leu Asp Leu Leu Leu Aβn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cyβ Glu Ser Aβp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Aβn He Gin Ala Lye His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cys Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Met Leu Ser Pro Ala Gly Ser Ser Trp Aβn He Aβn Pro He He Val 1650 1655 1660 Asp His Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lye 1665 1670 1675 1680

Gin He Arg Leu Arg Val Aβp Pro Gly Phe He Phe Aβp Ala Leu Ala 1685 1690 1695

Glu Val Aβn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Ala Phe Arg Pro Pro His Asp Asp Val Ala Lys Leu 1715 1720 1725

Leu Lys Asp He Asn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Aβn Leu Ala Aβn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760

Ser Ser Ala Cyβ Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cys Phe 1795 1800 1805

Tyr Aβn Ser Gly Val Ser Ala Aβn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu Hiβ Arg Met Gly Val 1825 1830 1835 1840

Gly Aβn He Val Lye Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Asp Cyβ Phe Aβn Phe He Val Ser Aβn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He Hiβ Ser Aβp He Glu Thr Leu Pro Asp Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935 Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Asn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lys G n Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly Hiβ He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Aβp Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

Thr Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Aβn Gly Pro Lys Leu Cyβ Lys Glu Leu He His Hiβ Asp 2035 2040 2045

Val Ala Ser Gly Gin Asp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly His He Leu Leu Tyr Ser Gly 2100 2105 2110

Aβn Lys Lys Leu He Asn Lys Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Asp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lys Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr Val Lye Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 13:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 13:

ACCAAACAAA GTTGGGTAAG GATAGTTCAA TCAATGATCA TTTTCTAGTG CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAAGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180

GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTT CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CCAATACTTT TCACATGATG ATCCAATTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCTCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GAAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAC CTTTACCAGC 1020

AAATGGGGGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTAAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260 GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320

AGATCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCGAGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGAG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGCCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCTTCC AACCGGCACA CCCCTAGACA TTGACACTGC ATCGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTTAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTATAGTGTA CAATGACAGA AATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GGCCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740

AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCATCA ACCATCCACT CCCACGATTG 1800

GAGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC ACCTGCAGGG AAGAGAAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GACCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCCCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTCT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC TCCGGACCCC 2460

GGTAGGGCCA GCACTTCCGG GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTG TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820 CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CTAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ATGATCTTGC CAAGTTCCAC 3300

CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360

CCAGTCGACC CAACTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTTGAT CGCTCCGATA CAACCCACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTATG TACATGTTTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATCCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CCCTGCCCTT AGGTGTTGGC AAATCCACAG CAAAGCCCGA AAAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AGTGCGGTTA ATCTGATACC GCTCGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATAGGC CCTGGGAAGA TCATCGACAA TACAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCGCTGA TAGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380 AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATGCCCGAA AACGACCCCC CTCACAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCGAAAGAC TCCACGGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACGGCA AGCGCGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCTGA TACAAGGCCA 4620

CCACCAGCCA CCCCAATCTG CATCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGC 4680

TGCCCCCGAT CCAAACCACC AACCGCATCC CCACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ATTGGAAGGC CCCTCCCCCT CTTCCTCAAC ACAAGAACTC CACAACCGAA CCGCACAAGC 4800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC TCCCCGGCAA 4860

ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGCCCA 49 0

CGGCGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG GACACCAACC CCCGAACAGA CCCAGCACCC AACCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGCCC CGATCCGGCG GGGAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCCCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAACTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940 GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAC 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420

CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TCCACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TCACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGAGGTATCC AGATGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATCATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTAGCA TAGTCTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACGGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCACCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TCATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTTG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500 TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTAGA CTTGTATTTA GGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACTTACCTAG TGGAAAAGCC 7980

TAATCTGAGC AGCAAAAGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATCTTGA 8100

GCAACCAGCC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACGGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CCCCTTATCA ACGGATGATC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAAC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTGATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAATCCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

GCCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC TACCTCTTCA ATGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAGGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACA A TCACTCACTC 9060 TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATCGCAG 9120 ATAGGGCTGC TAGTGAACCA ATCTCATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180 GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240 CGCTATCTGT CAACCAGATC TTATACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300 ATAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360 CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420 TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540 CGAGGAAGAT CCGTGAACTC CTCAAAAAGG GGAATTCGCT GTACTCCAAA GTCAGTGATA 9600 AGGTTTTCCA ATGCTTAAGG GACACTAACT CACGGCTTGG CCTAGGCTCC GAATTGAGGG 9660 AGGACATCAA GGAGAAAGTT ATTAACTTGG GAGTTTACAT GCACAGCTCC CAGTGGTTTG 9720 AGCCCTTTCT GTTTTGGTTT ACAGTCAAGA CTGAGATGAG GTCAGTGATT AAATCACAAA 9780 CCCATACTTG CCATAGGAGG AGACACACAC CTGTATTCTT CACTGGTAGT TCAGTTGAGT 9840 TGCTAATCTC TCGTGACCTT GTTGCTATAA TCAGTAAAGA GTCTCAACAT GTATATTACC 9900 TGACATTTGA ACTGGTTTTG ATGTATTGTG ATGTCATAGA GGGGAGGTTA ATGACAGAGA 9960 CCGCTATGAC TATTGATGCT AGGTATACAG AGCTTCTAGG AAGAGTCAGA TACATGTGGA 10020 AACTGATAGA TGGTTTCTTC CCTGCACTCG GGAATCCAAC TTATCAAATT GTAGCCATGC 10080 TGGAGCCTCT TTCACTTGCT TACCTGCAGC TGAGGGATAT AACAGTAGAA CTCAGAGGTG 10140 CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGATGTTCT TGACCAAAAC GGGTTTTCTG 10200 ATGAAGGTAC TTATCATGAG TTAATTGAAG CTCTAGATTA CATTTTCATA ACTGATGACA 10260 TACATCTGAC AGGGGAGATT TTCTCATTTT TCAGAAGTTT CGGCCACCCC AGACTTGAAG 10320 CAGTAACGGC TGCTGAAAAT GTTAGGAAAT ACATGAATCA GCCTAAAGTC ATTGTGTATG 10380 AGACTCTGAT GAAAGGTCAT GCCATATTTT GTGGAATCAT AATCAACGGC TATCGTGACA 10440 GGCACGGAGG CAGTTGGCCA CCGCTGACCC TCCCCCTGCA TGCTGCAGAC ACAATCCGGA 10500 ATGCTCAAGC TTCAGGTGAA GGGTTAACAC ATGAGCAGTG CGTTGATAAC TGGAAATCTT 10560 TTGCTGGAGT GAAATTTGGC TGCTTTATGC CTCTTAGCCT GGATAGTGAT CTGACAATGT 10620 CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTG GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCT CTAAGAAGCC 12660

ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12780

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CTAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCGAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATACA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTCATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740 GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800 AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860 GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920 CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980 AAGAGTTAGA AGAGTTCACA TTTCTCTTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040 GATTCGACAA CATCCAGGCA AAACACTTAT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100 GGACCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 14160 ATATCAAGGC AGAGGCTAGG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220 TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280 GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340 CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGCTTTCAGA CCCCCACACG 14400 ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460 GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520 CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAGG 14580 ACGGCTTGTT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAG GAGATACTTA 14640 AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700 AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760 TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820 TCAATTTCAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880 AGACCTTGCC TAACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940 TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000 GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCCCA TTATAGAGAA GTGAACCTTG 15060 TATACCCTAG ATACAGCAAC TTCATATCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120 AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGA 15180 GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240 CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300 CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCAAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TTTGGGGGCA CATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGCTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780

ACTAATTGGT TGAACTCCGG AACCCTAATC CTGCCCTAGG TGGTTAGGCA TTATTTGCAA 15840

TAGATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894 (2) INFORMATION FOR SEQ ID NO: 14:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 14:

Met Asp Ser Leu Ser Val Asn Gin He Leu Tyr Pro Glu Val His Leu 1 5 10 15

Asp Ser Pro He Val Thr Aβn Lys He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cyβ Gin Aβn 35 40 45

He Lys His Arg Leu Lys Asn Gly Phe Ser Asn Gin Met He He Asn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser His He Pro Tyr Pro Asn Cys Asn Gin Asp Leu Phe Asn 85 90 95

He Glu Asp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lys Glu Lys Val He Aβn Leu Gly Val Tyr Met Hiβ Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lys Thr Glu Met Arg 165 170 175

Ser Val He Lys Ser Gin Thr His Thr Cys His Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Mat 225 230 235 240

Thr Glu Thr Ala Met Thr He Aβp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lye Leu He Aβp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cys Phe Thr Glu He Hiβ Aβp Val Leu Aβp Gin Aβn Gly 305 310 315 320

Phe Ser Aβp Glu Gly Thr Tyr Hiβ Glu Leu He Glu Ala Leu Asp Tyr 325 330 335

He Phe He Thr Asp Asp He His Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365 Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cyβ Gly He He He Aβn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

His Glu Gin Cyβ Val Aβp Aβn Trp Lye Ser Phe Ala Gly Val Lye Phe 435 440 445

Gly Cyβ Phe Met Pro Leu Ser Leu Asp Ser Asp Leu Thr Met Tyr Leu 450 455 460

Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lye Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Aβp Val Phe Leu Aβn Aβp Ser Ser Phe Aβp Pro Tyr Aβp 500 505 510

Val He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lys Glu He Lys Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lys Met Thr Tyr Lys Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Asn Gly 565 570 575

Met Ala Lys Asp Glu His Asp Leu Thr Lys Ala Leu His Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lye Asp Leu Lys Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lys Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Aβn 610 615 620

Val Arg Ala Ala Lye Gly Phe He Gly Phe Pro Gin Val He Arg Gin 625 630 635 640 Asp Gin Aβp Thr Aβp Hiβ Pro Glu Aβn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu His Lys Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Asp Pro His Cyβ Pro Pro Asp Leu Asp Ala His He 705 710 715 720

Pro Leu Tyr Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735

Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Asn Leu Lys Lys Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Aβp Tyr Phe Val He Leu Arg Gin Arg Leu Hiβ Asp He Gly His 805 810 815

Hiβ Leu Lye Ala Aβn Glu Thr He Val Ser Ser Hiβ Phe Phe Val Tyr 820 825 830

Ser Lye Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lys 835 840 845

Ser He Ala Arg Cyβ Val Phe Trp Ser Glu Thr He Val Aβp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lye Ser He Glu 865 870 875 880

Arg Gly Tyr Aβp Arg Tyr Leu Ala Tyr Ser Leu Aβn Val Leu Lye Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Asp Val Val He Pro Leu Leu Thr Asn Asn Asp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Aβp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lys Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cys Val Gin Ser 995 1000 1005

He Thr Arg Leu Leu Lys Asn He Thr Ala Arg Phe Val Leu He His 1010 1015 1020

Ser Pro Asn Pro Met Leu Lys Gly Leu Phe His Asp Asp Ser Lys Glu 1025 1030 1035 1040

Glu Asp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg His He He Val 1045 1050 1055

Pro Arg Ala Ala His Glu He Leu Asp His Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lye Arg Aβn Val Leu He Aβp Lye Glu Ser Cys Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

His Leu He Arg Arg His Glu Thr Cys Val He Cys Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Asp 1185 1190 1195 1200 He Asp Lye Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Asp Glu Arg Thr Asp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Aβp Aβp Aβp Ser Ser Trp Aβn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Aβn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Aβn Leu Ala Hiβ Arg Leu Arg Aβp Arg Ser Thr Gin 1285 1290 1295

Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lye Lye Val Asp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp Thr Gly Ser Ser Aβn Thr Val 1345 1350 1355 1360

Leu Hiβ Leu Hiβ Val Glu Thr Aβp Cyβ Cyβ Val He Pro Met He Aβp 1365 1370 1375

His Pro Arg He Pro Ser Ser Arg Lys Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu He Tyr Asp Asn Ala Pro Leu He Asp Arg Aβp 1395 1400 1405

Thr Thr Arg Leu Tyr Thr Gin Ser Hiβ Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Asp Leu Val Thr Lys Phe Glu Lys Asp His Met 1445 1450 1455

Asn Glu He Ser Ala Leu He Gly Asp Asp Asp He Asn Ser Phe He 1460 1465 1470 Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Asn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He Hiβ 1540 1545 1550

Gly Pro Ser Leu Aβp Ala Gin Asn Leu His Thr Thr Val Cys Asn Met 1555 1560 1565

Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Asp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Asn He Gin Ala Lys His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Thr Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cyβ Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Asn He Asn Pro He He Val 1650 1655 1660

Aβp His Tyr Ser Cyβ Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lye 1665 1670 1675 1680

Gin He Arg Leu Arg Val Aβp Pro Gly Phe He Phe Asp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Ala Phe Arg Pro Pro His Asp Asp Val Ala Lys Leu 1715 1720 1725

Leu Lys Asp He Aβn Thr Ser Lye Hiβ Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Asn Leu Ala Asn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760

Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cyβ Phe 1795 1800 1805

Tyr Aβn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840

Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Asp Cys Phe Asn Phe He Val Ser Asn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He His Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Asp Thr He Glu Lys Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser His 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Aβn Arg Leu Met 1955 1960 1965

Aβn Pro Glu Lys He Lys Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cys 1985 1990 1995 2000

He Gin Ala He Val Gly Asp Ala Val Ser Arg Gly Asp He Asn Pro 2005 2010 2015

Thr Leu Lye Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030 Leu Ala He Asn Gly Pro Lys Leu Cys Lys Glu Leu He His Hiβ Aβp 2035 2040 2045

Val Ala Ser Gly Gin Aβp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Aβp Asn Gin Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe His Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly His He Leu Leu Tyr Ser Gly 2100 2105 2110

Asn Arg Lys Leu He Asn Lys Phe He Gin Aβn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Aβp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lys 2130 2135 2140

Ser Glu Lys Gin He He Met Thr Gly Gly Leu Lye Arg Glu Trp Val 2145 2150 2155 2160

Phe Lys Val Thr Val Lys Glu Thr Lys Glu Trp Tyr Lys Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lys Asp 2180

(2) INFORMATION FOR SEQ ID NO: 15:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15894 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 15:

ACCAAACAAA GTTGGGTAAG GATAGTTCAA TCAATGATCA TCTTCTAGTG CACTTAGGAT 60

TCAAGATCCT ATTATCAGGG ACAAGAGCAG GATTAGGGAT ATCCGAGATG GCCACACTTT 120

TAAGGAGCTT AGCATTGTTC AAAAGAAACA AGGACAAACC ACCCATTACA TCAGGATCCG 180 GTGGAGCCAT CAGAGGAATC AAACACATTA TTATAGTACC AATCCCTGGA GATTCCTCAA 240

TTACCACTCG ATCCAGACTT CTGGACCGGT TGGTCAGGTT AATTGGAAAC CCGGATGTGA 300

GCGGGCCCAA ACTAACAGGG GCACTAATAG GTATATTATC CTTATTTGTG GAGTCTCCAG 360

GTCAATTGAT TCAGAGGATC ACCGATGACC CTGACGTTAG CATAAGGCTG TTAGAGGTTG 420

TCCAGAGTGA CCAGTCACAA TCTGGCCTTA CCTTCGCATC AAGAGGTACC AACATGGAGG 480

ATGAGGCGGA CAAATACTTT TCACATGATG ATCCAATTAG TAGTGATCAA TCCAGGTTCG 540

GATGGTTCGA GAACAAGGAA ATCTCAGATA TTGAAGTGCA AGACCCTGAG GGATTCAACA 600

TGATTCTGGG TACCATCCTA GCCCAAATTT GGGTCTTGCT CGCAAAGGCG GTTACGGCCC 660

CAGACACGGC AGCTGATTCG GAGCTAAGAA GGTGGATAAA GTACACCCAA CAAAGAAGGG 720

TAGTTGGTGA ATTTAGATTG GAGAGAAAAT GGTTGGATGT GGTGAGGAAC AGGATTGCCG 780

AGGACCTCTC CTTACGCCGA TTCATGGTCG CTCTAATCCT GGATATCAAG AGAACACCCG 840

GAAACAAACC CAGGATTGCT GAAATGATAT GTGACATTGA TACATATATC GTAGAGGCAG 900

GATTAGCCAG TTTTATCCTG ACTATTAAGT TTGGGATAGA AACTATGTAT CCTGCTCTTG 960

GACTGCATGA ATTTGCTGGT GAGTTATCCA CACTTGAGTC CTTGATGAAC CTTTACCAGC 1020

AAATGGGGGA AACTGCACCC TACATGGTAA TCCTGGAGAA CTCAATTCAG AACAAGTTCA 1080

GTGCAGGATC ATACCCTCTG CTCTGGAGCT ATGCCATGGG AGTAGGAGTG GAACTTGAAA 1140

ACTCCATGGG AGGTTTGAAC TTTGGCCGAT CTTACTTTGA TCCAGCATAT TTTAGATTAG 1200

GGCAAGAGAT GGTAAGGAGG TCAGCTGGAA AGGTCAGTTC CACATTGGCA TCTGAACTCG 1260

GTATCACTGC CGAGGATGCA AGGCTTGTTT CAGAGATTGC AATGCATACT ACTGAGGACA 1320

AGATCAGTAG AGCGGTTGGA CCCAGACAAG CCCAAGTATC ATTTCTACAC GGTGATCAAA 1380

GTGAGAATGA GCTACCGAGA TTGGGGGGCA AGGAAGATAG GAGGGTCAAA CAGAGTCGAG 1440

GAGAAGCCAG GGAGAGCTAC AGAGAAACCG GGCCCAGCAG AGCAAGTGAT GCGAGAGCTG 1500

CCCATCTTCC AACCGGCACA CCCCTAGACA TTGACACTGC ATCGGAGTCC AGCCAAGATC 1560

CGCAGGACAG TCGAAGGTCA GCTGACGCCC TGCTTAGGCT GCAAGCCATG GCAGGAATCT 1620

CGGAAGAACA AGGCTCAGAC ACGGACACCC CTATAGTGTA CAATGACAGA AATCTTCTAG 1680

ACTAGGTGCG AGAGGCCGAG GACCAGAACA ACATCCGCCT ACCCTCCATC ATTGTTATAA 1740 AAAACTTAGG AACCAGGTCC ACACAGCCGC CAGCCCATCA ACCATCCACT CCCACGATTG 1800

GAGCCGATGG CAGAAGAGCA GGCACGCCAT GTCAAAAACG GACTGGAATG CATCCGGGCT 1860

CTCAAGGCCG AGCCCATCGG CTCACTGGCC ATCGAGGAAG CTATGGCAGC ATGGTCAGAA 1920

ATATCAGACA ACCCAGGACA GGAGCGAGCC ACCTGCAGGG AAGAGAAGGC AGGCAGTTCG 1980

GGTCTCAGCA AACCATGCCT CTCAGCAATT GGATCAACTG AAGGCGGTGC ACCTCGCATC 2040

CGCGGTCAGG GACCTGGAGA GAGCGATGAC GACGCTGAAA CTTTGGGAAT CCCCCCAAGA 2100

AATCTCCAGG CATCAAGCAC TGGGTTACAG TGTTATTATG TTTATGATCA CAGCGGTGAA 2160

GCGGTTAAGG GAATCCAAGA TGCTGACTCT ATCATGGTTC AATCAGGCCT TGATGGTGAT 2220

AGCACCCTAT CAGGAGGAGA CAATGAATCT GAAAACAGCG ATGTGGATAT TGGCGAACCT 2280

GATACCGAGG GATATGCTAT CACTGACCGG GGATCTGCTC CCATCTCTAT GGGGTTCAGG 2340

GCTTCTGATG TTGAAACTGC AGAAGGAGGG GAGATCCACG AGCTCCTGAG ACTCCAATCC 2400

AGAGGCAACA ACTTTCCGAA GCTTGGGAAA ACTCTCAATG TTCCTCCGCC CCCGGACCCC 2460

GGTAGGGCCA GCACTTCCGG GACACCCATT AAAAAGGGCA CAGACGCGAG ATTAGCCTCA 2520

TTTGGAACGG AGATCGCGTC TTTATTGACA GGTGGTGCAA CCCAATGTGC TCGAAAGTCA 2580

CCCTCGGAAC CATCAGGGCC AGGTGCACCT GCGGGGAATG TCCCCGAGTA TGTGAGCAAT 2640

GCCGCACTGA TACAGGAGTG GACACCCGAA TCTGGTACCA CAATCTCCCC GAGATCCCAG 2700

AATAATGAAG AAGGGGGAGA CTATTATGAT GATGAGCTGT TCTCTGATGT CCAAGATATT 2760

AAAACAGCCT TGGCCAAAAT ACACGAGGAT AATCAGAAGA TAATCTCCAA GCTAGAATCA 2820

CTGCTGTTAT TGAAGGGAGA AGTTGAGTCA ATTAAGAAGC AGATCAACAG GCAAAATATC 2880

AGCATATCCA CCCTGGAAGG ACACCTCTCA AGCATCATGA TCGCCATTCC TGGACTTGGG 2940

AAGGATCCCA ACGACCCCAC TGCAGATGTC GAAATCAATC CCGACTTGAA ACCCATCATA 3000

GGCAGAGATT CAGGCCGAGC ACTGGCCGAA GTTCTCAAGA AACCCGTTGC CAGCCGACAA 3060

CTCCAAGGAA TGACAAATGG ACGGACCAGT TCCAGAGGAC AGCTGCTGAA GGAATTTCAG 3120

CCAAAGCCGA TCGGGAAAAA GATGAGCTCA GCCGTCGGGT TTGTTCCTGA CACCGGCCCT 3180

GCATCACGCA GTGTAATCCG CTCCATTATA AAATCCAGCC GGCTAGAGGA GGATCGGAAG 3240

CGTTACCTGA TGACTCTCCT TGATGATATC AAAGGAGCCA ATGATCTTGC CAAGTTCCAC 3300 CAGATGCTGA TGAAGATAAT AATGAAGTAG CTACAGCTCA ACTTACCTGC CAACCCCATG 3360

CCAGTCGACC CAACTAGTAC AACCTAAATC CATTATAAAA AACTTAGGAG CAAAGTGATT 3420

GCCTCCCAAG TTCCACAATG ACAGAGATCT ACGACTTCGA CAAGTCGGCA TGGGACATCA 3480

AAGGGTCGAT CGCTCCGATA CAACCGACCA CCTACAGTGA TGGCAGGCTG GTGCCCCAGG 3540

TCAGAGTCAT AGATCCTGGT CTAGGCGACA GGAAGGATGA ATGCTTTATG TACATGTCTC 3600

TGCTGGGGGT TGTTGAGGAC AGCGATCCCC TAGGGCCTCC AATCGGGCGA GCATTTGGGT 3660

CCCTGCCCTT AGGTGTTGGC AGATCCACAG CAAAGCCCGA AAAACTCCTC AAAGAGGCCA 3720

CTGAGCTTGA CATAGTTGTT AGACGTACAG CAGGGCTCAA TGAAAAACTG GTGTTCTACA 3780

ACAACACCCC ACTAACTCTC CTCACACCTT GGAGAAAGGT CCTAACAACA GGGAGTGTCT 3840

TCAACGCAAA CCAAGTGTGC AATGCGGTTA ATCTGATACC GCTCGATACC CCGCAGAGGT 3900

TCCGTGTTGT TTATATGAGC ATCACCCGTC TTTCGGATAA CGGGTATTAC ACCGTTCCTA 3960

GAAGAATGCT GGAATTCAGA TCGGTCAATG CAGTGGCCTT CAACCTGCTG GTGACCCTTA 4020

GGATTGACAA GGCGATAGGC CCTGGGAAGA TCATCGACAA TACAGAGCAA CTTCCTGAGG 4080

CAACATTTAT GGTCCACATC GGGAACTTCA GGAGAAAGAA GAGTGAAGTC TACTCTGCCG 4140

ATTATTGCAA AATGAAAATC GAAAAGATGG GCCTGGTTTT TGCACTTGGT GGGATAGGGG 4200

GCACCAGTCT TCACATTAGA AGCACAGGCA AAATGAGCAA GACTCTCCAT GCACAACTCG 4260

GGTTCAAGAA GACCTTATGT TACCCGCTGA TGGATATCAA TGAAGACCTT AATCGATTAC 4320

TCTGGAGGAG CAGATGCAAG ATAGTAAGAA TCCAGGCAGT TTTGCAGCCA TCAGTTCCTC 4380

AAGAATTCCG CATTTACGAC GACGTGATCA TAAATGATGA CCAAGGACTA TTCAAAGTTC 4440

TGTAGACCGT AGTGCCCAGC AATGCCCGAA AACGACCCCC CTCACAATGA CAGCCAGAAG 4500

GCCCGGACAA AAAAGCCCCC TCCGAAAGAC TCCACTGACC AAGCGAGAGG CCAGCCAGCA 4560

GCCGACGGCA AGCACGAACA CCAGGCGGCC CCAGCACAGA ACAGCCCTGA TACAAGGCCA 4620

CCACCAGCCA CCCCAATCTG CATCCTCCTC GTGGGACCCC CGAGGACCAA CCCCCAAGGC 4680

TGCCCCCGAT CCAAACCACC AACCGCATCC CCACCACCCC CGGGAAAGAA ACCCCCAGCA 4740

ATTGGAAGGC CCCTCCCCCT CTTCCTCAAC ACAAGAACTC CACAACCGAA CCGCACAAGC 800

GACCGAGGTG ACCCAACCGC AGGCATCCGA CTCCCTAGAC AGATCCTCTC TCCCCGGCAA 4860 ACTAAACAAA ACTTAGGGCC AAGGAACATA CACACCCAAC AGAACCCAGA CCCCGGCCCA 4920

CGGCGCCGCG CCCCCAACCC CCGACAACCA GAGGGAGCCC CCAACCAATC CCGCCGGCTC 4980

CCCCGGTGCC CACAGGCAGG GACACCAACC CCCGAACAGA CCCAGCACCT AACCATCGAC 5040

AATCCAAGAC GGGGGGGCCC CCCCAAAAAA AGGCCCCCAG GGGCCGACAG CCAGCACCGC 5100

GAGGAAGCCC ACCCACCCCA CACACGACCA CGGCAACCAA ACCAGAACCC AGACCACCCT 5160

GGGCCACCAG CTCCCAGACT CGGCCATCAC CCCGCAGAAA GGAAAGGCCA CAACCCGCGC 5220

ACCCCAGCCC CGATCCGGCG GGGAGCCACC CAACCCGAAC CAGCACCCAA GAGCGATCCC 5280

CGAAGGACCC CCGAACCGCA AAGGACATCA GTATCCCACA GCCTCTCCAA GTCCCCCGGT 5340

CTCCTCCTCT TCTCGAAGGG ACCAAAAGAT CAATCCACCA CACCCGACGA CACTCAACTC 5400

CCCACCCCTA AAGGAGACAC CGGGAATCCC AGAATCAAGA CTCATCCAAT GTCCATCATG 5460

GGTCTCAAGG TGAACGTCTC TGCCATATTC ATGGCAGTAC TGTTAACTCT CCAAACACCC 5520

ACCGGTCAAA TCCATTGGGG CAATCTCTCT AAGATAGGGG TGGTAGGAAT AGGAAGTGCA 5580

AGCTACAAAG TTATGACTCG TTCCAGCCAT CAATCATTAG TCATAAAATT AATGCCCAAT 5640

ATAACTCTCC TCAATAACTG CACGAGGGTA GAGATTGCAG AATACAGGAG ACTACTGAGA 5700

ACAGTTTTGG AACCAATTAG AGATGCACTT AATGCAATGA CCCAGAATAT AAGACCGGTT 5760

CAGAGTGTAG CTTCAAGTAG GAGACACAAG AGATTTGCGG GAGTAGTCCT GGCAGGTGCG 5820

GCCCTAGGCG TTGCCACAGC TGCTCAGATA ACAGCCGGCA TTGCACTTCA CCAGTCCATG 5880

CTGAACTCTC AAGCCATCGA CAATCTGAGA GCGAGCCTGG AAACTACTAA TCAGGCAATT 5940

GAGGCAATCA GACAAGCAGG GCAGGAGATG ATATTGGCTG TTCAGGGTGT CCAAGACTAC 6000

ATCAATAATG AGCTGATACC GTCTATGAAC CAACTATCTT GTGATTTAAT CGGCCAGAAG 6060

CTCGGGCTCA AATTGCTCAG ATACTATACA GAAATCCTGT CATTATTTGG CCCCAGCTTA 6120

CGGGACCCCA TATCTGCGGA GATATCTATC CAGGCTTTGA GCTATGCGCT TGGAGGAGAC 6180

ATCAATAAGG TGTTAGAAAA GCTCGGATAC AGTGGAGGTG ATTTACTGGG CATCTTAGAG 6240

AGCAGAGGAA TAAAGGCCCG GATAACTCAC GTCGACACAG AGTCCTACTT CATTGTCCTC 6300

AGTATAGCCT ATCCGACGCT GTCCGAGATT AAGGGGGTGA TTGTCCACCG GCTAGAGGGG 6360

GTCTCGTACA ACATAGGCTC TCAAGAGTGG TATACCACTG TGCCCAAGTA TGTTGCAACC 6420 CAAGGGTACC TTATCTCGAA TTTTGATGAG TCATCGTGTA CTTTCATGCC AGAGGGGACT 6480

GTGTGCAGCC AAAATGCCTT GTACCCGATG AGTCCTCTGC TCCAAGAATG CCTCCGGGGG 6540

TACACCAAGT CCTGTGCTCG TACACTCGTA TCCGGGTCTT TTGGGAACCG GTTCATTTTA 6600

TCACAAGGGA ACCTAATAGC CAATTGTGCA TCAATCCTTT GCAAGTGTTA CACAACAGGA 6660

ACGATCATTA ATCAAGACCC TGACAAGATC CTAACATACA TTGCTGCCGA TAACTGCCCG 6720

GTAGTCGAGG TGAACGGCGT GACCATCCAA GTCGGGAGCA GGAGGTATCC AGACGCTGTG 6780

TACTTGCACA GAATTGACCT CGGTCCTCCC ATATTATTGG AGAGGTTGGA CGTAGGGACA 6840

AATCTGGGGA ATGCAATTGC TAAGTTGGAG GATGCCAAGG AATTGTTGGA GTCATCGGAC 6900

CAGATATTGA GGAGTATGAA AGGTTTATCG AGCACTTGCA TAGTCTACAT CCTGATTGCA 6960

GTGTGTCTTG GAGGGTTGAT AGGGATCCCC GCTTTAATAT GTTGCTGCAG GGGGCGTTGT 7020

AACAAAAAGG GAGAACAAGT TGGTATGTCA AGACCAGGCC TAAAGCCTGA TCTTACGGGA 7080

ACATCAAAAT CCTATGTAAG GTCGCTCTGA TCCTCTACAA CTCTTGAAAC ACAAATGTCC 7140

CACAAGTCTC CTCTTCGTCA TCAAGCAACC ACCGCACCCA GCATCAAGCC CACCTGAAAT 7200

TATCTCCGGC TTCCCTCTGG CCGAACAATA TCGGTAGTTA ATTAAAACTT AGGGTGCAAG 7260

ATCATCCACA ATGTCACCAC AACGAGACCG GATAAATGCC TTCTACAAAG ATAACCCCCA 7320

TCCCAAGGGA AGTAGGATAG TCATTAACAG AGAACATCTT ATGATTGATA GACCTTATGT 7380

TTTGCTGGCT GTTCTGTTTG TCATGTTTCT GAGCTTGATC GGGTTGCTAG CCATTGCAGG 7440

CATTAGACTT CATCGGGCAG CCATCTACAC CGCAGAGATC CATAAAAGCC TCAGCACCAA 7500

TCTAGATGTA ACTAACTCAA TCGAGCATCA GGTCAAGGAC GTGCTGACAC CACTCTTCAA 7560

AATCATCGGT GATGAAGTGG GCCTGAGGAC ACCTCAGAGA TTCACTGACC TAGTGAAATT 7620

CATCTCTGAC AAGATTAAAT TCCTTAATCC GGATAGGGAG TACGACTTCA GAGATCTCAC 7680

TTGGTGTATC AACCCGCCAG AGAGAATCAA ATTGGATTAT GATCAATACT GTGCAGATGT 7740

GGCTGCTGAA GAGCTCATGA ATGCATTGGT GAACTCAACT CTACTGGAGA CCAGAACAAC 7800

CAATCAGTTC CTAGCTGTCT CAAAGGGAAA CTGCTCAGGG CCCACTACAA TCAGAGGTCA 7860

ATTCTCAAAC ATGTCGCTGT CCCTGTTAGA CTTGTATTTA GGTCGAGGTT ACAATGTGTC 7920

ATCTATAGTC ACTATGACAT CCCAGGGAAT GTATGGGGGA ACTTACCTAG TGGAAAAGCC 7980 TAATCTGAGC AGCAAAAGGT CAGAGTTGTC ACAACTGAGC ATGTACCGAG TGTTTGAAGT 8040

AGGTGTTATC AGAAATCCGG GTTTGGGGGC TCCGGTGTTC CATATGACAA ACTATCTTGA 8100

GCAACCAGTC AGTAATGATC TCAGCAACTG TATGGTGGCT TTGGGGGAGC TCAAACTCGC 8160

AGCCCTTTGT CACCGGGAAG ATTCTATCAC AATTCCCTAT CAGGGATCAG GGAAAGGTGT 8220

CAGCTTCCAG CTCGTCAAGC TAGGTGTCTG GAAATCCCCA ACCGACATGC AATCCTGGGT 8280

CACCTTATCA ACGGATGATC CAGTGATAGA CAGGCTTTAC CTCTCATCTC ACAGAGGTGT 8340

TATCGCTGAC AATCAAGCAA AATGGGCTGT CCCGACAACA CGAACAGATG ACAAGTTGCG 8400

AATGGAGACA TGCTTCCAAC AGGCGTGTAA GGGTAAAATC CAAGCACTCT GCGAGAATCC 8460

CGAGTGGGCA CCATTGAAGG ATAACAGGAT TCCTTCATAC GGGGTCTTGT CTGTTGATCT 8520

GAGTCTGACA GTTGAGCTTA AAATCAAAAT TGCTTCGGGA TTCGGGCCAT TGATCACACA 8580

CGGTTCAGGG ATGGACCTAT ACAAATCCAA CCACAACAAT GTGTATTGGC TGACTATCCC 8640

ACCAATGAAG AACCTAGCCT TAGGTGTAAT CAACACATTG GAGTGGATAC CGAGATTCAA 8700

GGTTAGTCCC TACCTCTTCA ATGTCCCAAT TAAGGAAGCA GGCGAAGACT GCCATGCCCC 8760

AACATACCTA CCTGCGGAGG TGGATGGTGA TGTCAAACTC AGTTCCAATC TGGTGATTCT 8820

ACCTGGTCAA GATCTCCAAT ATGTTTTGGC AACCTACGAT ACTTCCAGGG TTGAACATGC 8880

TGTGGTTTAT TACGTTTACA GCCCAAGCCG CTCATTTTCT TACTTTTATC CTTTTAGGTT 8940

GCCTATAAAG GGGGTCCCCA TCGAATTACA AGTGGAATGC TTCACATGGG ACCAAAAACT 9000

CTGGTGCCGT CACTTCTGTG TGCTTGCGGA CTCAGAATCT GGTGGACATA TCACTCACTC 9060

TGGGATGGTG GGCATGGGAG TCAGCTGCAC AGTCACCCGG GAAGATGGAA CCAATCGCAG 9120

ATAGGGCTGC TAGTGAACTA ATCTCATGAT GTCACCCAGA CATCAGGCAT ACCCACTAGT 9180

GTGAAATAGA CATCAGAATT AAGAAAAACG TAGGGTCCAA GTGGTTCCCC GTTATGGACT 9240

CGCTATCTGT CAACCAGATC TTATACCCTG AAGTTCACCT AGATAGCCCG ATAGTTACCA 9300

ATAAGATAGT AGCCATCCTG GAGTATGCTC GAGTCCCTCA CGCTTACAGC CTGGAGGACC 9360

CTACACTGTG TCAGAACATC AAGCACCGCC TAAAAAACGG ATTTTCCAAC CAAATGATTA 9420

TAAACAATGT GGAAGTTGGG AATGTCATCA AGTCCAAGCT TAGGAGTTAT CCGGCCCACT 9480

CTCATATTCC ATATCCAAAT TGTAATCAGG ATTTATTTAA CATAGAAGAC AAAGAGTCAA 9540 CGAGGAAGAT CCGTGAACTC CTCAAAAAGG AGGTTTTCCA ATGCTTAAGG GACACTAACT AGGACATCAA GGAGAAAGTT ATTAACTTGG AGCCCTTTCT GTTTTGGTTT ACAGTCAAGA CCCATACTTG CCATAGGAGG AGACACACAC TGCTAATCTC TCGTGACCTT GTTGCTATAA TGACATTTGA ACTGGTTTTG ATGTATTGTG CCGCTATGAC TATTGATGCT AGGTATACAG AACTGATAGA TGGTTTCTTC CCTGCACTCG TGGAGCCTCT TTCACTTGCT TACCTGCAGC CTTTCCTTAA CCACTGCTTT ACTGAAATAC ATGAAGGTAC TTATCATGAG TTAATTGAAG TACATCTGAC AGGGGAGATT TTCTCATTTT CAGTAACGGC TGCTGAAAAT GTTAGGAAAT AGACTCTGAT GAAAGGTCAT GCCATATTTT GGCACGGAGG CAGTTGGCCA CCGCTGACCC ATGCTCAAGC TTCAGGTGAA GGGTTAACAC TTGCTGGAGT GAAATTTGGC TGCTTTATGC ACCTAAAGGA CAAGGCACTT GCTGCTCTCC AGTTCCTGCG TTACGACCCT CCCAAGGGAA TTAATGATTC GAGCTTTGAC CCATATGATG TCCATGACCC TGAGTTCAAC CTGTCTTACA GTAGACTTTT TGCTAAAATG ACTTACAAAA TAATCTCAAA CGGGATTGGC AAATATTTTA ATTTGACTAA GGCACTCCAC ACTCTAGCTG GTCACAGGGG GGGGCCAGTC TTAAAAACCT GGAACGTGAG AGCAGCAAAA GGGTTTATAG GGTTCCCTCA AGTAATTCGG CAGGACCAAG 11160

ACACTGATCA TCCGGAGAAT ATGGAAGCTT ACGAGACAGT CAGTGCATTT ATCACGACTG 11220

ATCTCAAGAA GTACTGCCTT AATTGGAGAT ATGAGACCAT CAGCTTGTTT GCACAGAGGC 11280

TAAATGAGAT TTACGGATTG CCCTCATTTT TCCAGTGGCT GCATAAGAGG CTTGAGACCT 11340

CTGTCCTGTA TGTAAGTGAC CCTCATTGCC CCCCCGACCT TGACGCCCAT ATCCCGTTAT 11400

ATAAAGTCCC CAATGATCAA ATCTTCATTA AGTACCCTAT GGGAGGTATA GAAGGGTATT 11460

GTCAGAAGCT GTGGACCATC AGCACCATTC CCTATCTATA CCTGGCTGCT TATGAGAGCG 11520

GAGTAAGGAT TGCTTCGTTA GTGCAAGGGG ACAATCAGAC CATAGCCGTA ACAAAAAGGG 11580

TACCCAGCAC ATGGCCCTAC AACCTTAAGA AACGGGAAGC TGCTAGAGTA ACTAGAGATT 11640

ACTTTGTAAT TCTTAGGCAA AGGCTACATG ATATTGGCCA TCACCTCAAG GCAAATGAGA 11700

CAATTGTTTC ATCACATTTT TTTGTCTATT CAAAAGGAAT ATATTATGAT GGGCTACTTG 11760

TGTCCCAATC ACTCAAGAGC ATCGCAAGAT GTGTATTCTG GTCAGAGACT ATAGTTGATG 11820

AAACAAGGGC AGCATGCAGT AATATTGCTA CAACAATGGC TAAAAGCATC GAGAGAGGTT 11880

ATGACCGTTA CCTTGCATAT TCCCTGAACG TCCTAAAAGT GATACAGCAA ATTCTGATCT 11940

CTCTTGGCTT CACAATCAAT TCAACCATGA CCCGGGATGT AGTCATACCC CTCCTCACAA 12000

ACAACGACCT CTTAATAAGG ATGGCACTGT TGCCCGCTCC TATTGGGGGG ATGAATTATC 12060

TGAATATGAG CAGGCTGTTT GTCAGAAACA TCGGTGATCC AGTAACATCA TCAATTGCTG 12120

ATCTCAAGAG AATGATTCTC GCCTCACTAA TGCCTGAAGA GACCCTCCAT CAAGTAATGA 12180

CACAACAACC GGGGGACTCT TCATTCCTAG ACTGGGCTAG CGACCCTTAC TCAGCAAATC 12240

TTGTATGTGT CCAGAGCATC ACTAGACTCC TCAAGAACAT AACTGCAAGG TTTGTCCTGA 12300

TCCATAGTCC AAACCCAATG TTAAAAGGAT TATTCCATGA TGACAGTAAA GAAGAGGACG 12360

AGGGACTGGC GGCATTCCTC ATGGACAGGC ATATTATAGT ACCTAGGGCA GCTCATGAAA 12420

TCCTGGATCA TAGTGTCACA GGGGCAAGAG AGTCTATTGC AGGCATGCTG GATACCACAA 12480

AAGGCCTGAT TCGAGCCAGC ATGAGGAAGG GGGGGTTAAC CTCTCGAGTG ATAACCAGAT 12540

TGTCCAATTA TGACTATGAA CAATTCAGAG CAGGGATGGT GCTATTGACA GGAAGAAAGA 12600

GAAATGTCCT CATTGACAAA GAGTCATGTT CAGTGCAGCT GGCGAGAGCT CTAAGAAGCC 12660 ATATGTGGGC GAGGCTAGCT CGAGGACGGC CTATTTACGG CCTTGAGGTC CCTGATGTAC 12720

TAGAATCTAT GCGAGGCCAC CTTATTCGGC GTCATGAGAC ATGTGTCATC TGCGAGTGTG 12 80

GATCAGTCAA CTACGGATGG TTTTTTGTCC CCTCGGGTTG CCAACTGGAT GATATTGACA 12840

AGGAAACATC ATCCTTGAGA GTCCCATATA TTGGTTCTAC CACTGATGAG AGAACAGACA 12900

TGAAGCTTGC CTTCGTAAGA GCCCCAAGTC GATCCTTGCG ATCTGCTGTT AGAATAGCAA 12960

CAGTGTACTC ATGGGCTTAC GGTGATGATG ATAGCTCTTG GAACGAAGCC TGGTTGTTGG 13020

CTAGGCAAAG GGCCAATGTG AGCCTGGAGG AGCTAAGGGT GATCACTCCC ATCTCAACTT 13080

CGACTAATTT AGCGCATAGG TTGAGGGATC GTAGCACTCA AGTGAAATAC TCAGGTACAT 13140

CCCTTGTCCG AGTGGCGAGG TATACCACAA TCTCCAACGA CAATCTCTCA TTTGTCATAT 13200

CAGATAAGAA GGTTGATACT AACTTTATAT ACCAACAAGG AATGCTTCTA GGGTTGGGTG 13260

TTTTAGAAAC ATTGTTTCGA CTCGAGAAAG ATACCGGATC ATCTAACACG GTATTACATC 13320

TTCACGTCGA AACAGATTGT TGCGTGATCC CGATGATAGA TCATCCCAGG ATACCCAGCT 13380

CCCGCAAGCT AGAGCTGAGG GCAGAGCTAT GTACCAACCC ATTGATATAT GATAATGCAC 13440

CTTTAATTGA CAGAGATACA ACAAGGCTAT ACACCCAGAG CCATAGGAGG CACCTTGTGG 13500

AATTTGTTAC ATGGTCCACA CCCCAACTAT ATCACATTTT AGCTAAGTCC ACAGCACTAT 13560

CTATGATTGA CCTGGTAACA AAATTTGAGA AGGACCATAT GAATGAAATT TCAGCTCTCA 13620

TAGGGGATGA CGATATCAAT AGTTTCATAA CTGAGTTTCT GCTCATAGAG CCAAGATTAT 13680

TCACTATCTA CTTGGGCCAG TGTGCGGCCA TCAATTGGGC ATTTGATGTA CATTATCATA 13740

GACCATCAGG GAAATATCAG ATGGGTGAGC TGTTGTCATC GTTCCTTTCT AGAATGAGCA 13800

AAGGAGTGTT TAAGGTGCTT GTCAATGCTC TAAGCCACCC AAAGATCTAC AAGAAATTCT 13860

GGCATTGTGG TATTATAGAG CCTATCCATG GTCCTTCACT TGATGCTCAA AACTTGCACA 13920

CAACTGTGTG CAACATGGTT TACACATGCT ATATGACCTA CCTCGACCTG TTGTTGAATG 13980

AAGAGTTAGA AGAGTTCACA TTTCTCTTGT GTGAAAGCGA CGAGGATGTA GTACCGGACA 14040

GATTCGACAA CATCCAGGCA AAACACTTAT GTGTTCTGGC AGATTTGTAC TGTCAACCAG 14100

GGGCCTGCCC ACCAATTCGA GGTCTAAGAC CGGTAGAGAA ATGTGCAGTT CTAACCGACC 14160

ATATCAAGGC AGAGGCTAGG TTATCTCCAG CAGGATCTTC GTGGAACATA AATCCAATTA 14220 TTGTAGACCA TTACTCATGC TCTCTGACTT ATCTCCGGCG AGGATCGATC AAACAGATAA 14280

GATTGAGAGT TGATCCAGGA TTCATTTTCG ACGCCCTCGC TGAGGTAAAT GTCAGTCAGC 14340

CAAAGATCGG CAGCAACAAC ATCTCAAATA TGAGCATCAA GGCTTTCAGA CCCCCACACG 14400

ATGATGTTGC AAAATTGCTC AAAGATATCA ACACAAGCAA GCACAATCTT CCCATTTCAG 14460

GGGGCAATCT CGCCAATTAT GAAATCCATG CTTTCCGCAG AATCGGGTTG AACTCATCTG 14520

CTTGCTACAA AGCTGTTGAG ATATCAACAT TAATTAGGAG ATGCCTTGAG CCAGGGGAGG 14580

ACGGCTTGTT CTTGGGTGAG GGATCGGGTT CTATGTTGAT CACTTATAAG GAGATACTTA 14640

AACTAAACAA GTGCTTCTAT AATAGTGGGG TTTCCGCCAA TTCTAGATCT GGTCAAAGGG 14700

AATTAGCACC CTATCCCTCC GAAGTTGGCC TTGTCGAACA CAGAATGGGA GTAGGTAATA 14760

TTGTCAAAGT GCTCTTTAAC GGGAGGCCCG AAGTCACGTG GGTAGGCAGT GTAGATTGCT 14820

TCAATTTCAT AGTTAGTAAT ATCCCTACCT CTAGTGTGGG GTTTATCCAT TCAGATATAG 14880

AGACCTTGCC TAACAAAGAT ACTATAGAGA AGCTAGAGGA ATTGGCAGCC ATCTTATCGA 14940

TGGCTCTGCT CCTGGGCAAA ATAGGATCAA TACTGGTGAT TAAGCTTATG CCTTTCAGCG 15000

GGGATTTTGT TCAGGGATTT ATAAGTTATG TAGGGTCTTA TTATAGAGAA GTGAACCTTG 15060

TATACCCTAG ATACAGCAAC TTCATATCTA CTGAATCTTA TTTGGTTATG ACAGATCTCA 15120

AGGCTAACCG GCTAATGAAT CCTGAAAAGA TTAAGCAGCA GATAATTGAA TCATCTGTGA 15180

GGACTTCACC TGGACTTATA GGTCACATCC TATCCATTAA GCAACTAAGC TGCATACAAG 15240

CAATTGTGGG AGACGCAGTT AGTAGAGGTG ATATCAATCC TACTCTGAAA AAACTTACAC 15300

CTATAGAGCA GGTGCTGATC AATTGCGGGT TGGCAATTAA CGGACCTAAG CTGTGCAAAG 15360

AATTGATCCA CCATGATGTT GCCTCAGGGC AAGATGGATT GCTTAATTCT ATACTCATCC 15420

TCTACAGGGA GTTGGCAAGA TTCAAAGACA ACCGAAGAAG TCAACAAGGG ATGTTCCACG 15480

CTTACCCCGT ATTGGTAAGT AGCAGGCAAC GAGAACTTAT ATCTAGGATC ACCCGCAAAT 15540

TTTGGGGGCA CATTCTTCTT TACTCCGGGA ACAGAAAGTT GATAAATAAG TTTATCCAGA 15600

ATCTCAAGTC CGGCTATCTG ATACTAGACT TACACCAGAA TATCTTCGTT AAGAATCTAT 15660

CCAAGTCAGA GAAACAGATT ATTATGACGG GGGGTTTGAA ACGTGAGTGG GTTTTTAAGG 15720

TAACAGTCAA GGAGACCAAA GAATGGTATA AGTTAGTCGG ATACAGTGCC CTGATTAAGG 15780 ACTAATTGAT TGAACTCCGG AACCCTAATC CTGCCCTAGG TGGTTAGGCA TTATTTGCAA 15840 TATATTAAAG AAAACTTTGA AAATACGAAG TTTCTATTCC CAGCTTTGTC TGGT 15894

(2) INFORMATION FOR SEQ ID NO: 16:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2183 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 16:

Met Aβp Ser Leu Ser Val Aβn Gin He Leu Tyr Pro Glu Val Hiβ Leu 1 5 10 15

Aβp Ser Pro He Val Thr Asn Lye He Val Ala He Leu Glu Tyr Ala 20 25 30

Arg Val Pro His Ala Tyr Ser Leu Glu Asp Pro Thr Leu Cys Gin Asn 35 40 45

He Lye Hiβ Arg Leu Lys Asn Gly Phe Ser Asn Gin Met He He Aβn 50 55 60

Asn Val Glu Val Gly Asn Val He Lys Ser Lys Leu Arg Ser Tyr Pro 65 70 75 80

Ala His Ser Hiβ He Pro Tyr Pro Asn Cys Asn Gin Asp Leu Phe Asn 85 90 95

He Glu Asp Lys Glu Ser Thr Arg Lys He Arg Glu Leu Leu Lys Lys 100 105 110

Gly Asn Ser Leu Tyr Ser Lys Val Ser Asp Lys Val Phe Gin Cys Leu 115 120 125

Arg Asp Thr Asn Ser Arg Leu Gly Leu Gly Ser Glu Leu Arg Glu Asp 130 135 140

He Lys Glu Lys Val He Asn Leu Gly Val Tyr Met His Ser Ser Gin 145 150 155 160

Trp Phe Glu Pro Phe Leu Phe Trp Phe Thr Val Lye Thr Glu Met Arg 165 170 175 Ser Val He Lys Ser Gin Thr Hiβ Thr Cyβ Hiβ Arg Arg Arg His Thr 180 185 190

Pro Val Phe Phe Thr Gly Ser Ser Val Glu Leu Leu He Ser Arg Asp 195 200 205

Leu Val Ala He He Ser Lys Glu Ser Gin His Val Tyr Tyr Leu Thr 210 215 220

Phe Glu Leu Val Leu Met Tyr Cys Asp Val He Glu Gly Arg Leu Met 225 230 235 240

Thr Glu Thr Ala Met Thr He Asp Ala Arg Tyr Thr Glu Leu Leu Gly 245 250 255

Arg Val Arg Tyr Met Trp Lys Leu He Asp Gly Phe Phe Pro Ala Leu 260 265 270

Gly Asn Pro Thr Tyr Gin He Val Ala Met Leu Glu Pro Leu Ser Leu 275 280 285

Ala Tyr Leu Gin Leu Arg Asp He Thr Val Glu Leu Arg Gly Ala Phe 290 295 300

Leu Asn His Cyβ Phe Thr Glu He His Asp Val Leu Aβp Gin Aβn Gly 305 310 315 320

Phe Ser Aβp Glu Gly Thr Tyr Hiβ Glu Leu He Glu Ala Leu Aep Tyr 325 330 335

He Phe He Thr Aβp Asp He His Leu Thr Gly Glu He Phe Ser Phe 340 345 350

Phe Arg Ser Phe Gly His Pro Arg Leu Glu Ala Val Thr Ala Ala Glu 355 360 365

Asn Val Arg Lys Tyr Met Asn Gin Pro Lys Val He Val Tyr Glu Thr 370 375 380

Leu Met Lys Gly His Ala He Phe Cys Gly He He He Asn Gly Tyr 385 390 395 400

Arg Asp Arg His Gly Gly Ser Trp Pro Pro Leu Thr Leu Pro Leu His 405 410 415

Ala Ala Asp Thr He Arg Asn Ala Gin Ala Ser Gly Glu Gly Leu Thr 420 425 430

Hiβ Glu Gin Cys Val Asp Asn Trp Lys Ser Phe Ala Gly Val Lys Phe 435 440 445

Gly Cys Phe Met Pro Leu Ser Leu Aβp Ser Asp Leu Thr Met Tyr Leu 450 455 460

Lys Asp Lys Ala Leu Ala Ala Leu Gin Arg Glu Trp Asp Ser Val Tyr 465 470 475 480

Pro Lys Glu Phe Leu Arg Tyr Asp Pro Pro Lys Gly Thr Gly Ser Arg 485 490 495

Arg Leu Val Asp Val Phe Leu Asn Asp Ser Ser Phe Asp Pro Tyr Aβp 500 505 510

Val He Met Tyr Val Val Ser Gly Ala Tyr Leu His Asp Pro Glu Phe 515 520 525

Asn Leu Ser Tyr Ser Leu Lys Glu Lye Glu He Lye Glu Thr Gly Arg 530 535 540

Leu Phe Ala Lye Met Thr Tyr Lye Met Arg Ala Cys Gin Val He Ala 545 550 555 560

Glu Asn Leu He Ser Asn Gly He Gly Lys Tyr Phe Lys Asp Aβn Gly 565 570 575

Met Ala Lye Asp Glu Hiβ Asp Leu Thr Lys Ala Leu Hiβ Thr Leu Ala 580 585 590

Val Ser Gly Val Pro Lys Asp Leu Lye Glu Ser His Arg Gly Gly Pro 595 600 605

Val Leu Lye Thr Tyr Ser Arg Ser Pro Val His Thr Ser Thr Arg Asn 610 615 620

Val Arg Ala Ala Lys Gly Phe He Gly Phe Pro Gin Val He Arg Gin 625 630 635 640

Asp Gin Asp Thr Asp His Pro Glu Aβn Met Glu Ala Tyr Glu Thr Val 645 650 655

Ser Ala Phe He Thr Thr Aβp Leu Lye Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Thr He Ser Leu Phe Ala Gin Arg Leu Asn Glu He Tyr Gly 675 680 685

Leu Pro Ser Phe Phe Gin Trp Leu Hiβ Lye Arg Leu Glu Thr Ser Val 690 695 700

Leu Tyr Val Ser Aβp Pro His Cys Pro Pro Asp Leu Asp Ala His He 705 710 715 720

Pro Leu Tyr Lys Val Pro Asn Asp Gin He Phe He Lys Tyr Pro Met 725 730 735 Gly Gly He Glu Gly Tyr Cys Gin Lys Leu Trp Thr He Ser Thr He 740 745 750

Pro Tyr Leu Tyr Leu Ala Ala Tyr Glu Ser Gly Val Arg He Ala Ser 755 760 765

Leu Val Gin Gly Asp Asn Gin Thr He Ala Val Thr Lys Arg Val Pro 770 775 780

Ser Thr Trp Pro Tyr Aβn Leu Lys Lys Arg Glu Ala Ala Arg Val Thr 785 790 795 800

Arg Aβp Tyr Phe Val He Leu Arg Gin Arg Leu Hiβ Asp He Gly His 805 810 815

His Leu Lys Ala Asn Glu Thr He Val Ser Ser Hiβ Phe Phe Val Tyr 820 825 830

Ser Lye Gly He Tyr Tyr Asp Gly Leu Leu Val Ser Gin Ser Leu Lye 835 840 845

Ser He Ala Arg Cys Val Phe Trp Ser Glu Thr He Val Asp Glu Thr 850 855 860

Arg Ala Ala Cys Ser Asn He Ala Thr Thr Met Ala Lys Ser He Glu 865 870 875 880

Arg Gly Tyr Aβp Arg Tyr Leu Ala Tyr Ser Leu Asn Val Leu Lys Val 885 890 895

He Gin Gin He Leu He Ser Leu Gly Phe Thr He Asn Ser Thr Met 900 905 910

Thr Arg Asp Val Val He Pro Leu Leu Thr Asn Asn Aβp Leu Leu He 915 920 925

Arg Met Ala Leu Leu Pro Ala Pro He Gly Gly Met Asn Tyr Leu Asn 930 935 940

Met Ser Arg Leu Phe Val Arg Asn He Gly Asp Pro Val Thr Ser Ser 945 950 955 960

He Ala Asp Leu Lys Arg Met He Leu Ala Ser Leu Met Pro Glu Glu 965 970 975

Thr Leu His Gin Val Met Thr Gin Gin Pro Gly Asp Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Ala Asn Leu Val Cyβ Val Gin Ser 995 1000 1005 He Thr Arg Leu Leu Lys Aβn He Thr Ala Arg Phe Val Leu He Hiβ 1010 1015 1020

Ser Pro Aβn Pro Met Leu Lye Gly Leu Phe His Asp Asp Ser Lys Glu 1025 1030 1035 1040

Glu Aβp Glu Gly Leu Ala Ala Phe Leu Met Asp Arg Hiβ He He Val 1045 1050 1055

Pro Arg Ala Ala Hiβ Glu He Leu Aβp Hiβ Ser Val Thr Gly Ala Arg 1060 1065 1070

Glu Ser He Ala Gly Met Leu Asp Thr Thr Lys Gly Leu He Arg Ala 1075 1080 1085

Ser Met Arg Lys Gly Gly Leu Thr Ser Arg Val He Thr Arg Leu Ser 1090 1095 1100

Asn Tyr Asp Tyr Glu Gin Phe Arg Ala Gly Met Val Leu Leu Thr Gly 1105 1110 1115 1120

Arg Lys Arg Asn Val Leu He Asp Lye Glu Ser Cyβ Ser Val Gin Leu 1125 1130 1135

Ala Arg Ala Leu Arg Ser His Met Trp Ala Arg Leu Ala Arg Gly Arg 1140 1145 1150

Pro He Tyr Gly Leu Glu Val Pro Asp Val Leu Glu Ser Met Arg Gly 1155 1160 1165

Hiβ Leu He Arg Arg Hiβ Glu Thr Cyβ Val He Cyβ Glu Cys Gly Ser 1170 1175 1180

Val Asn Tyr Gly Trp Phe Phe Val Pro Ser Gly Cys Gin Leu Asp Aβp 1185 1190 1195 1200

He Aβp Lye Glu Thr Ser Ser Leu Arg Val Pro Tyr He Gly Ser Thr 1205 1210 1215

Thr Aβp Glu Arg Thr Aβp Met Lys Leu Ala Phe Val Arg Ala Pro Ser 1220 1225 1230

Arg Ser Leu Arg Ser Ala Val Arg He Ala Thr Val Tyr Ser Trp Ala 1235 1240 1245

Tyr Gly Asp Asp Asp Ser Ser Trp Asn Glu Ala Trp Leu Leu Ala Arg 1250 1255 1260

Gin Arg Ala Asn Val Ser Leu Glu Glu Leu Arg Val He Thr Pro He 1265 1270 1275 1280

Ser Thr Ser Thr Asn Leu Ala His Arg Leu Arg Asp Arg Ser Thr Gin 1285 1290 1295

Val Lys Tyr Ser Gly Thr Ser Leu Val Arg Val Ala Arg Tyr Thr Thr 1300 1305 1310

He Ser Asn Asp Asn Leu Ser Phe Val He Ser Asp Lys Lys Val Asp 1315 1320 1325

Thr Asn Phe He Tyr Gin Gin Gly Met Leu Leu Gly Leu Gly Val Leu 1330 1335 1340

Glu Thr Leu Phe Arg Leu Glu Lys Asp , Thr Gly Ser Ser Asn Thr Val 1345 1350 1355 1360

Leu His Leu His Val Glu Thr Aβp Cyβ Cyβ Val He Pro Met He Aβp 1365 1370 1375

Hiβ Pro Arg He Pro Ser Ser Arg Lye Leu Glu Leu Arg Ala Glu Leu 1380 1385 1390

Cys Thr Asn Pro Leu lie Tyr Asp Aβn Ala Pro Leu He Asp Arg Asp 1395 1400 1405

Thr Thr Arg Leu Tyr Thr Gin Ser His Arg Arg His Leu Val Glu Phe 1410 1415 1420

Val Thr Trp Ser Thr Pro Gin Leu Tyr His He Leu Ala Lys Ser Thr 1425 1430 1435 1440

Ala Leu Ser Met He Aβp Leu Val Thr Lye Phe Glu Lys Asp His Met 1445 1450 1455

Asn Glu He Ser Ala Leu He Gly Asp Asp Asp He Asn Ser Phe He 1460 1465 1470

Thr Glu Phe Leu Leu He Glu Pro Arg Leu Phe Thr He Tyr Leu Gly 1475 1480 1485

Gin Cys Ala Ala He Asn Trp Ala Phe Asp Val His Tyr His Arg Pro 1490 1495 1500

Ser Gly Lys Tyr Gin Met Gly Glu Leu Leu Ser Ser Phe Leu Ser Arg 1505 1510 1515 1520

Met Ser Lys Gly Val Phe Lys Val Leu Val Asn Ala Leu Ser His Pro 1525 1530 1535

Lys He Tyr Lys Lys Phe Trp His Cys Gly He He Glu Pro He His 1540 1545 1550

Gly Pro Ser Leu Asp Ala Gin Asn Leu Hiβ Thr Thr Val Cys Asn Met 1555 1560 1565 Val Tyr Thr Cys Tyr Met Thr Tyr Leu Asp Leu Leu Leu Asn Glu Glu 1570 1575 1580

Leu Glu Glu Phe Thr Phe Leu Leu Cys Glu Ser Asp Glu Asp Val Val 1585 1590 1595 1600

Pro Asp Arg Phe Asp Aβn He Gin Ala Lys His Leu Cys Val Leu Ala 1605 1610 1615

Asp Leu Tyr Cys Gin Pro Gly Ala Cys Pro Pro He Arg Gly Leu Arg 1620 1625 1630

Pro Val Glu Lys Cys Ala Val Leu Thr Asp His He Lys Ala Glu Ala 1635 1640 1645

Arg Leu Ser Pro Ala Gly Ser Ser Trp Aβn He Asn Pro He He Val 1650 1655 1660

Asp His Tyr Ser Cys Ser Leu Thr Tyr Leu Arg Arg Gly Ser He Lys 1665 1670 1675 1680

Gin He Arg Leu Arg Val Asp Pro Gly Phe He Phe Aβp Ala Leu Ala 1685 1690 1695

Glu Val Asn Val Ser Gin Pro Lys He Gly Ser Asn Asn He Ser Asn 1700 1705 1710

Met Ser He Lys Ala Phe Arg Pro Pro His Asp Asp Val Ala Lys Leu 1715 1720 1725

Leu Lys Asp He Aβn Thr Ser Lys His Asn Leu Pro He Ser Gly Gly 1730 1735 1740

Asn Leu Ala Asn Tyr Glu He His Ala Phe Arg Arg He Gly Leu Asn 1745 1750 1755 1760

Ser Ser Ala Cys Tyr Lys Ala Val Glu He Ser Thr Leu He Arg Arg 1765 1770 1775

Cys Leu Glu Pro Gly Glu Asp Gly Leu Phe Leu Gly Glu Gly Ser Gly 1780 1785 1790

Ser Met Leu He Thr Tyr Lys Glu He Leu Lys Leu Asn Lys Cys Phe 1795 1800 1805

Tyr Asn Ser Gly Val Ser Ala Asn Ser Arg Ser Gly Gin Arg Glu Leu 1810 1815 1820

Ala Pro Tyr Pro Ser Glu Val Gly Leu Val Glu His Arg Met Gly Val 1825 1830 1835 1840 Gly Asn He Val Lys Val Leu Phe Asn Gly Arg Pro Glu Val Thr Trp 1845 1850 1855

Val Gly Ser Val Asp Cyβ Phe Aβn Phe He Val Ser Aβn He Pro Thr 1860 1865 1870

Ser Ser Val Gly Phe He Hiβ Ser Asp He Glu Thr Leu Pro Asn Lys 1875 1880 1885

Aβp Thr He Glu Lye Leu Glu Glu Leu Ala Ala He Leu Ser Met Ala 1890 1895 1900

Leu Leu Leu Gly Lys He Gly Ser He Leu Val He Lys Leu Met Pro 1905 1910 1915 1920

Phe Ser Gly Asp Phe Val Gin Gly Phe He Ser Tyr Val Gly Ser Tyr 1925 1930 1935

Tyr Arg Glu Val Asn Leu Val Tyr Pro Arg Tyr Ser Asn Phe He Ser 1940 1945 1950

Thr Glu Ser Tyr Leu Val Met Thr Asp Leu Lys Ala Asn Arg Leu Met 1955 1960 1965

Asn Pro Glu Lys He Lys Gin Gin He He Glu Ser Ser Val Arg Thr 1970 1975 1980

Ser Pro Gly Leu He Gly His He Leu Ser He Lys Gin Leu Ser Cyβ 1985 1990 1995 2000

He Gin Ala He Val Gly Aβp Ala Val Ser Arg Gly Aβp He Asn Pro 2005 2010 2015

Thr Leu Lys Lys Leu Thr Pro He Glu Gin Val Leu He Asn Cys Gly 2020 2025 2030

Leu Ala He Aβn Gly Pro Lye Leu Cyβ Lye Glu Leu He Hiβ His Asp 2035 2040 2045

Val Ala Ser Gly Gin Asp Gly Leu Leu Asn Ser He Leu He Leu Tyr 2050 2055 2060

Arg Glu Leu Ala Arg Phe Lys Asp Asn Arg Arg Ser Gin Gin Gly Met 2065 2070 2075 2080

Phe Hiβ Ala Tyr Pro Val Leu Val Ser Ser Arg Gin Arg Glu Leu He 2085 2090 2095

Ser Arg He Thr Arg Lys Phe Trp Gly His He Leu Leu Tyr Ser Gly 2100 2105 2110

Asn Arg Lys Leu He Asn Lys Phe He Gin Asn Leu Lys Ser Gly Tyr 2115 2120 2125

Leu He Leu Asp Leu His Gin Asn He Phe Val Lys Asn Leu Ser Lye 2130 2135 2140

Ser Glu Lye Gin He He Met Thr Gly Gly Leu Lye Arg Glu Trp Val 2145 2150 2155 2160

Phe Lye Val Thr Val Lys Glu Thr Lye Glu Trp Tyr Lye Leu Val Gly 2165 2170 2175

Tyr Ser Ala Leu He Lye Asp 2180

(2) INFORMATION FOR SEQ ID NO: 17:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 17:

ACCAAACAAG AGAAGAAACT TGTCTGGGAA TATAAATTTA ACTTTAAATT AACTTAGGAT 60

TAAAGACATT GACTAGAAGG TCAAGAAAAG GGAACTCTAT AATTTCAAAA ATGTTGAGCC 120

TATTTGATAC ATTTAATGCA CGTAGGCAAG AAAACATAAC AAAATCAGCC GGTGGAGCTA 180

TCATTCCTGG ACAGAAAAAT ACTGTCTCTA TATTCGCCCT TGGACCGACA ATAACTGATG 240

ATAATGAGAA AATGACATTA GCTCTTCTAT TTCTATCTCA TTCACTAGAT AATGAGAAAC 300

AACATGCACA AAGGGCAGGG TTCTTGGTGT CTTTATTGTC AATGGCTTAT GCCAATCCAG 360

AGCTCTACCT AACAACAAAT GGAAGTAATG CAGATGTCAA GTATGTCATA TACATGATTG 420

AGAAAGATCT AAAACGGCAA AAGTATGGAG GATTTGTGGT TAAGACGAGA GAGATGATAT 480

ATGAAAAGAC AACTGATTGG ATATTTGGAA GTGACCTGGA TTATGATCAG GAAACTATGT 540

TGCAGAACGG CAGGAACAAT TCAACAATTG AAGACCTTGT CCACACATTT GGGTATCCAT 600

CATGTTTAGG AGCTCTTATA ATACAGATCT GGATAGTTCT GGTCAAAGCT ATCACTAGTA 660

TCTCAGGGTT AAGAAAAGGC TTTTTCACCC GATTGGAAGC TTTCAGACAA GATGGAACAG 720 TGCAGGCAGG GCTGGTATTG AGCGGTGACA CAGTGGATCA GATTGGGTCA ATCATGCGGT 780 CTCAACAGAG CTTGGTAACT CTTATGGTTG AAACATTAAT AACAATGAAT ACCAGCAGAA 840 ATGACCTCAC AACCATAGAA AAGAATATAC AAATTGTTGG CAACTACATA AGAGATGCAG 900 GTCTCGCTTC ATTCTTCAAT ACAATCAGAT ATGGAATTGA GACCAGAATG GCAGCTTTGA 960

CTCTATCCAC TCTCAGACCA GATATCAATA GATTAAAAGC TTTGATGGAA CTGTATTTAT 1020

CAAAGGGACC ACGCGCTCCT TTCATCTGTA TCCTCAGAGA TCCTATACAT GGTGAGTTCG 1080

CACCAGGCAA CTATCCTGCC ATATGGAGCT ATGCAATGGG GGTGGCAGTT GTACAAAATA 1140

GAGCCATGCA ACAGTATGTG ACGGGAAGAT CATATCTAGA CATTGATATG TTCCAGCTAG 1200

GACAAGCAGT AGCACGTGAT GCCGAAGCTC AAATGAGCTC AACACTGGAA GATGAACTTG 1260

GAGTGACACA CGAATCTAAA GAAAGCTTGA AGAGACATAT AAGGAACATA AACAGTTCAG 1320

AGACATCTTT CCACAAACCG ACAGGTGGAT CAGCCATAGA GATGGCAATA GATGAAGAGC 1380

CAGAACAATT CGAACATAGA GCAGATCAAG AACAAAATGG AGAACCTCAA TCATCCATAA 1440

TTCAATATGC CTGGGCAGAA GGAAATAGAA GCGATGATCA GACTGAGCAA GCTACAGAAT 1500

CTGACAATAT CAAGACCGAA CAACAAAACA TCAGAGACAG ACTAAACAAG AGACTCAACG 1560

ACAAGAAGAA ACAAAGCAGT CAACCACCCA CTAATCCCAC AAACAGAACA AACCAGGACG 1620

AAATAGATGA TCTGTTTAAC GCATTTGGAA GCAACTAATC GAATCAACAT TTTAATCTAA 1680

ATCAATAATA AATAAGAAAA ACTTAGGATT AAAGAATCCT ATCATACCGG AATATAGGGT 1740

GGTAAATTTA GAGTCTGCTT GAAACTCAAT CAATAGAGAG TTGATGGAAA GCGATGCTAA 1800

AAACTATCAA ATCATGGATT CTTGGGAAGA GGAATCAAGA GATAAATCAA CTAATATCTC 1860

CTCGGCCCTC AACATCATTG AATTCATACT CAGCACCGAC CCCCAAGAAG ACTTATCGGA 1920

AAACGACACA ATCAACACAA GAACCCAGCA ACTCAGTGCC ACCATCTGTC AACCAGAAAT 1980

CAAACCAACA GAAACAAGTG AGAAAGATAG TGGATCAACT GACAAAAATA GACAGTCCGG 2040

GTCATCACAC GAATGTACAA CAGAAGCAAA AGATAGAAAT ATTGATCAGG AAACTGTACA 2100

GAGAGGACCT GGGAGAAGAA GCAGCTCAGA TAGTAGAGCT GAGACTGTGG TCTCTGGAGG 2160

AATCCCCAGA AGCATCACAG ATTCTAAAAA TGGAACCCAA AACACGGAGG ATATTGATCT 2220

CAATGAAATT AGAAAGATGG ATAAGGACTC TATTGAGGGG AAAATGCGAC AATCTGCAAA 2280 TGTTCCAAGC GAGATATCAG GAAGTGATGA CATATTTACA ACAGAACAAA GTAGAAACAG 2340

TGATCATGGA AGAAGCCTGG AATCTATCAG TACACCTGAT ACAAGATCAA TAAGTGTTGT 2400

TACTGCTGCA ACACCAGATG ATGAAGAAGA AATACTAATG AAAAATAGTA GGAGAAAGAA 2460

AAGTTCTTCA ACACATCAAG AAGATGACAA AAGAATTAAA AAAGGGGGAA AAGGGAAAGA 2520

CTGGTTTAAG AAATCAAAAG ATACCGACAA CCAGATACCA ACATCAGACT ACAGATCCAC 2580

ATCAAAAGGG CAGAAGAAAA TCTCAAAGAC AACAACCACC AACACCGACA CAAAGGGGCA 2640

AACAGAAATA CAGACAGAAT CATCAGAAAC ACAATCCTCA TCATGGAATC TCATCATCGA 2700

CAACAACACC GACCGGAACG AACAGACAAG CACAACTCCT CCAACAACAA CTTCCAGATC 2760

AACTTATACA AAAGAATCGA TCCGAACAAA CTCTGAATCC AAACCCAAGA CACAAAAGAC 2820

AAATGGAAAG GAAAGGAAGG ATACAGAAGA GAGCAATCGA TTTACAGAGA GGGCAATTAC 2880

TCTATTGCAG AATCTTGGTG TAATTCAATC CACATCAAAA CTAGATTTAT ATCAAGACAA 2940

ACGAGTTGTA TGTGTAGCAA ATGTACTAAA CAATGTAGAT ACTGCATCAA AGATAGATTT 3000

CCTGGCAGGA TTAGTCATAG GGGTTTCAAT GGACAACGAC ACAAAATTAA CACAGATACA 3060

AAATGAAATG CTAAACCTCA AAGCAGATCT AAAGAAAATG GACGAATCAC ATAGAAGATT 3120

GATAGAAAAT CAAAGAGAAC AACTGTCATT GATCACGTCA CTAATTTCAA ATCTCAAAAT 3180

TATGACTGAG AGAGGAGGAA AGAAAGACCA AAATGAATCC AATGAGAGAG TATCCATGAT 3240

CAAAACAAAA TTGAAAGAAG AAAAGATCAA GAAGACCAGG TTTGACCCAC TTATGGAGGC 3300

ACAAGGCATT GACAAGAATA TACCCGATCT ATATCGACAT GCAGGAGATA CACTAGAGAA 3360

CGATGTACAA GTTAAATCAG AGATATTAAG TTCATACAAT GAGTCAAATG CAACAAGACT 3420

AATACCCAAA AAAGTGAGCA GTACAATGAG ATCACTAGTT GCAGTCATCA ACAACAGCAA 3480

TCTCTCACAA AGCACAAAAC AATCATACAT AAACGAACTC AAACGTTGCA AAAATGATGA 3540

AGAAGTATCT GAATTAATGG ACATGTTCAA TGAAGATGTC AACAATTGCC AATGATCCAA 3600

CAAAGAAACG ACACCGAACA AACAGACAAG AAACAACAGT AGATCAAAAC CTGTCAACAC 36 0

ACACAAAATC AAGCAGAATG AAACAACAGA TATCAATCAA TATACAAATA AGAAAAACTT 3720

AGGATTAAAG AATAAATTAA TCCTTGTCCA AAATGAGTAT AACTAACTCT GCAATATACA 3780

CATTCCCAGA ATCATCATTC TCTGAAAATG GTCATATAGA ACCATTACCA CTCAAAGTCA 3840 ATGAACAGAG GAAAGCAGTA CCCCACATTA GAGTTGCCAA GATCGGAAAT CCACCAAAAC 3900

ACGGATCCCG GTATTTAGAT GTCTTCTTAC TCGGCTTCTT CGAGATGGAA CGAATCAAAG 3960

ACAAATACGG GAGTGTGAAT GATCTCGACA GTGACCCGAG TTACAAAGTT TGTGGCTCTG 4020

GATCATTACC AATCGGATTG GCTAAGTACA CTGGGAATGA CCAGGAATTG TTACAAGCCG 4080

CAACCAAACT GGATATAGAA GTGAGAAGAA CAGTCAAAGC GAAAGAGATG GTTGTTTACA 4140

CGGTACAAAA TATAAAACCA GAACTGTACC CATGGTCCAA TAGACTAAGA AAAGGAATGC 4200

TGTTCGATGC CAACAAAGTT GCTCTTGCTC CTCAATGTCT TCCACTAGAT AGGAGCATAA 4260

AATTTAGAGT AATCTTCGTG AATTGTACGG CAATTGGATC AATAACCTTG TTCAAAATTC 4320

CTAAGTCAAT GGCATCACTA TCTCTACCCA ACACAATATC AATCAATCTG CAGGTACACA 4380

TAAAAACAGG GGTTCAGACT GATTCTAAAG GGATAGTTCA AATTTTGGAT GAGAAAGGCG 4440

AAAAATCACT GAATTTCATG GTCCATCTCG GATTGATCAA AAGAAAAGTA GGCAGAATGT 4500

ACTCTGTTGA ATACTGTAAA CAGAAAATCG AGAAAATGAG ATTGATATTT TCTTTAGGAC 4560

TAGTTGGAGG AATCAGTCTT CATGTCAATG CAACTGGGTC CATATCAAAA ACACTAGCAA 4620

GTCAGCTGGT ATTCAAAAGA GAGATTTGTT ATCCTTTAAT GGATCTAAAT CCGCATCTCA 4680

ATCTAGTTAT CTGGGCTTCA TCAGTAGAGA TTACAAGAGT GGATGCAATT TTCCAACCTT 4740

CTTTACCTGG CGAGTTCAGA TACTATCCTA ATATTATTGC AAAAGGAGTT GGGAAAATCA 4800

AACAATGGAA CTAGTAATCT CTATTTTAGT CCGGACGTAT CTATTAAGCC GAAGCAAATA 4860

AAGGATAATC AAAAACTTAG GACAAAAGAG GTCAATACCA ACAACTATTA GCAGTCACAC 4920

TCGCAAGAAT AAGAGAGAAG GGACCAAAAA AGTCAAATAG GAGAAATCAA AACAAAAGGT 4980

ACAGAACACC AGAACAACAA AATCAAAACA TCCAACTCAC TCAAAACAAA AATTCCAAAA 5040

GAGACCGGCA ACACAACAAG CACTGAACAC AATGCCAACT TCAATACTGC TAATTATTAC 5100

AACCATGATC ATGGCATCTT TCTGCCAAAT AGATATCACA AAACTACAGC ACGTAGGTGT 5160

ATTGGTCAAC AGTCCCAAAG GGATGAAGAT ATCACAAAAC TTTGAAACAA GATATCTAAT 5220

TTTGAGCCTC ATACCAAAAA TAGAAGACTC TAACTCTTGT GGTGACCAAC AGATCAAGCA 5280

ATACAAGAAG TTATTGGATA GACTGATCAT CCCTTTATAT GATGGATTAA GATTACAGAA 5340

AGATGTGATA GTAACCAATC AAGAATCCAA TGAAAACACT GATCCCAGAA CAAAACGATT 5400 CTTTGGAGGG GTAATTGGAA CCATTGCTCT GGGAGTAGCA ACCTCAGCAC AAATTACAGC 5460

GGCAGTTGCT CTGGTTGAAG CCAAGCAGGC AAGATCAGAC ATCGAAAAAC TCAAAGAAGC 5520

AATTAGGGAC ACAAACAAAG CAGTGCAGTC AGTTCAGAGC TCCATAGGAA ATTTAATAGT 5580

AGCAATTAAA TCAGTCCAGG ATTATGTTAA CAAAGAAATC GTGCCATCGA TTGCGAGGCT 5640

AGGTTGTGAA GCAGCAGGAC TTCAATTAGG AATTGCATTA ACACAGCATT ACTCAGAATT 5700

AACAAACATA TTTGGTGATA ACATAGGATC GTTACAAGAA AAAGGAATAA AATTACAAGG 5760

TATAGCATCA TTATACCGCA CAAATATCAC AGAAATATTC ACAACATCAA CAGTTGATAA 5820

ATATGATATC TATGATCTGT TATTTACAGA ATCAATAAAG GTGAGAGTTA TAGATGTTGA 5880

CTTGAATGAT TACTCAATCA CCCTCCAAGT CAGACTCCCT TTATTAACTA GGCTGCTGAA 5940

CACTCAGATC TACAAAGTAG ATTCCATATC ATATAACATC CAAAACAGAG AATGGTATAT 6000

CCCTCTTCCC AGCCATATCA TGACGAAAGG GGCATTTCTA GGTGGAGCAG ACGTCAAAGA 6060

ATGTATAGAA GCATTCAGCA GCTATATATG CCCTTCTGAT CCAGGATTTG TATTAAACCA 6120

TGAAATAGAG AGCTGCTTAT CAGGAAACAT ATCCCAATGT CCAAGAACAA CGGTCACATC 6180

AGACATTGTT CCAAGATATG CATTTGTCAA TGGAGGAGTG GTTGCAAACT GTATAACAAC 6240

CACCTGTACA TGCAACGGAA TTGGTAATAG AATCAATCAA CCACCTGATC AAGGAGTAAA 6300

AATTATAACA CATAAAGAAT GTAGTACAAT AGGTATCAAC GGAATGCTGT TCAATACAAA 6360

TAAAGAAGGA ACTCTTGCAT TCTATACACC AAATGATATA ACACTAAACA ATTCTGTTGC 6420

ACTTGATCCA ATTGACATAT CAATCGAGCT CAACAAGGCC AAATCAGATC TAGAAGAATC 6480

AAAAGAATGG ATAAGAAGGT CAAATCAAAA ACTAGATTCT ATTGGAAATT GGCATCAATC 6540

TAGCACTACA ATCATAATTA TTTTGATAAT GATCATTATA TTGTTTATAA TTAATATAAC 6600

GATAATTACA ATTGCAATTA AGTATTACAG AATTCAAAAG AGAAATCGAG TGGATCAAAA 6660

TGACAAGCCA TATGTACTAA CAAACAAATA ACATATCTAC AGATCATTAG ATATTAAAAT 6720

TATAAAAAAC TTAGGAGTAA AGTTACGCAA TCCAACTCTA CTCATATAAT TGAGGAAGGA 6780

CCCAATAGAC AAATCCAAAT TCGAGATGGA ATACTGGAAG CATACCAATC ACGGAAAGGA 6840

TGCTGGTAAT GAGCTGGAGA CGTCTATGGC TACTCATGGC AACAAGCTCA CTAATAAGAT 6900

AATATACATA TTATGGACAA TAATCCTGGT GTTATTATCA ATAGTCTTCA TCATAGTGCT 6960 AATTAATTCC ATCAAAAGTG AAAAGGCCCA CGAATCATTG CTGCAAGACA TAAATAATGA 7020

GTTTATGGAA ATTACAGAAA AGATCCAAAT GGCATCGGAT AATACCAATG ATCTAATACA 7080

GTCAGGAGTG AATACAAGGC TTCTTACAAT TCAGAGTCAT GTCCAGAATT ACATACCAAT 7140

ATCATTGACA CAACAGATGT CAGATCTTAG GAAATTCATT AGTGAAATTA CAATTAGAAA 7200

TGATAATCAA GAAGTGCTGC CACAAAGAAT AACACATGAT GTAGGTATAA AACCTTTAAA 7 60

TCCAGATGAT TTTTGGAGAT GCACGTCTGG TCTTCCATCT TTAATGAAAA CTCCAAAAAT 7320

AAGGTTAATG CCAGGGCCGG GATTATTAGC TATGCCAACG ACTGTTGATG GCTGTGTTAG 7380

AACTCCGTCT TTAGTTATAA ATGATCTGAT TTATGCTTAT ACCTCAAATC TAATTACTCG 7440

AGGTTGTCAG GATATAGGAA AATCATATCA AGTCTTACAG ATAGGGATAA TAACTGTAAA 7500

CTCAGACTTG GTACCTGACT TAAATCCTAG GATCTCTCAT ACCTTTAACA TAAATGACAA 7560

TAGGAAGTCA TGTTCTCTAG CACTCCTAAA TACAGATGTA TATCAACTGT GTTCAACTCC 7620

CAAAGTTGAT GAAAGATCAG ATTATGCATC ATCAGGCATA GAAGATATTG TACTTGATAT 7680

TGTCAATTAT GATGGTTCAA TCTCAACAAC AAGATTTAAG AATAATAACA TAAGCTTTGA 7740

TCAACCATAT GCTGCACTAT ACCCATCTGT TGGACCAGGG ATATACTACA AAGGCAAAAT 7800

AATATTTCTC GGGTATGGAG GTCTTGAACA TCCAATAAAT GAGAATGTAA TCTGCAACAC 7860

AACTGGGTGC CCCGGGAAAA CACAGAGAGA CTGTAATCAA GCGTCTCATA GTCCATGGTT 7920

TTCAGATAGG AGGATGGTCA ACTCCATCAT TGTTGTTGAC AAAGGCTTAA ACTCAATTCC 7980

AAAATTGAAA GTATGGACGA TATCTATGCG ACAAAATTAC TGGGGGTCAG AAGGAAGGTT 8040

ACTTCTACTA GGTAACAAGA TCTATATATA TACAAGATCT ACAAGTTGGC ATAGCAAGTT 8100

ACAATTAGGA ATAATTGATA TTACTGATTA CAGTGATATA AGGATAAAAT GGACATGGCA 8160

TAATGTGCTA TCAAGACCAG GAAACAATGA ATGTCCATGG GGACATTCAT GTCCAGATGG 8220

ATGTATAACA GGAGTATATA CTGATGCATA TCCACTCAAT CCCACAGGGA GCATTGTGTC 8280

ATCTGTCATA TTAGACTCAC AAAAATCGAG AGTGAACCCA GTCATAACTT ACTCAACAGC 8340

AACCGAAAGA GTAAACGAGC TGGCCATCCT AAACAGAACA CTCTCAGCTG GATATACAAC 8400

AACAAGCTGC ATTACACACT ATAACAAAGG ATATTGTTTT CATATAGTAG AAATAAATCA 8460

TAAAAGCTTA AACACATTTC AACCCATGTT GTTCAAAACA GAGATTCCAA AAAGCTGCAG 8520 TTAATCATAA TTAACCATAA TATGCATCAA TCTATCTATA ATACAAGTAT ATGATAAGTA 8580

ATCAGCAATC AGACAATAGA CAAAAGGGAA ATATAAAAAA CTTAGGAGCA AAGCGTGCTC 8640

GGGAAATGGA CACTGAATCT AACAATGGCA CTGTATCTGA CATACTCTAT CCTGAGTGTC 8700

ACCTTAACTC TCCTATCGTT AAAGGTAAAA TAGCACAATT ACACACTATT ATGAGTCTAC 8760

CTCAGCCTTA TGATATGGAT GACGACTCAA TACTAGTTAT CACTAGACAG AAAATAAAAC 8820

TTAATAAATT GGATAAAAGA CAACGATCTA TTAGAAGATT AAAATTAATA TTAACTGAAA 8880

AAGTGAATGA CTTAGGAAAA TACACATTTA TCAGATATCC AGAAATGTCA AAAGAAATGT 8940

TCAAATTATA TATACCTGGT ATTAACAGTA AAGTGACTGA ATTATTACTT AAAGCAGATA 9000

GAACATATAG TCAAATGACT GATGGATTAA GAGATCTATG GATTAATGTG CTATCAAAAT 9060

TAGCCTCAAA AAATGATGGA AGCAATTATG ATCTTAATGA AGAAATTAAT AATATATCGA 9120

AAGTTCACAC AACCTATAAA TCAGATAAAT GGTATAATCC ATTCAAAACA TGGTTTACTA 9180

TCAAGTATGA TATGAGAAGA TTACAAAAAG CTCGAAATGA GATCACTTTT AATGTTGGGA 9240

AGGATTATAA CTTGTTAGAA GACCAGAAGA ATTTCTTATT GATACATCCA GAATTGGTTT 9300

TGATATTAGA TAAACAAAAC TATAATGGTT ATCTAATTAC TCCTGAATTA GTATTGATGT 9360

ATTGTGACGT AGTCGAAGGC CGATGGAATA TAAGTGCATG TGCTAAGTTA GATCCAAAAT 9420

TACAATCTAT GTATCAGAAA GGTAATAACC TGTGGGAAGT GATAGATAAA TTGTTTCCAA 9480

TTATGGGAGA AAAGACATTT GATGTGATAT CGTTATTAGA ACCACTTGCA TTATCCTTAA 9540

TTCAAACTCA TGATCCTGTT AAACAACTAA GAGGAGCTTT TTTAAATCAT GTGTTATCCG 9600

AGATGGAATT AATATTTGAA TCTAGAGAAT CGATTAAGGA ATTTCTGAGT GTAGATTACA 9660

TTGATAAAAT TTTAGATATA TTTAATAAGT CTACAATAGA TGAAATAGCA GAGATTTTCT 9720

CTTTTTTTAG AACATTTGGG CATCCTCCAT TAGAAGCTAG TATTGCAGCA GAAAAGGTTA 9780

GAAAATATAT GTATATTGGA AAACAATTAA AATTTGACAC TATTAATAAA TGTCATGCTA 9840

TCTTCTGTAC AATAATAATT AACGGATATA GAGAGAGGCA TGGTGGACAG TGGCCTCCTG 9900

TGACATTACC TGATCATGCA CACGAATTCA TCATAAATGC TTACGGTTCA AACTCTGCGA 9960

TATCATATGA AAATGCTGTT GATTATTACC AGAGCTTTAT AGGAATAAAA TTCAATAAAT 10020

TCATAGAGCC TCAGTTAGAT GAGGATTTGA CAATT ATAT GAAAGATAAA GCATTATCTC 10080 CAAAAAAATC AAATTGGGAC ACAGTTTATC CTGCATCTAA TTTACTGTAC CGTACTAACG 10140 CATCCAACGA ATCACGAAGA TTAGTTGAAG TATTTATAGC AGATAGTAAA TTTGATCCTC 10200 ATCAGATATT GGATTATGTA GAATCTGGGG ACTGGTTAGA TGATCCAGAA TTTAATATTT 10260 CTTATAGTCT TAAAGAAAAA GAGATCAAAC AGGAAGGTAG ACTCTTTGCA AAAATGACAT 10320 ACAAAATGAG AGCTACACAA GTTTTATCAG AGACACTACT TGCAAATAAC ATAGGAAAAT 10380 TCTTTCAAGA AAATGGGATG GTGAAGGGAG AGATTGAATT ACTTAAGAGA TTAACAACCA 10440 TATCAATATC AGGAGTTCCA CGGTATAATG AAGTGTACAA TAATTCTAAA AGCCATACAG 10500 ATGACCTTAA AACCTACAAT AAAATAAGTA ATCTTAATTT GTCTTCTAAT CAGAAATCAA 10560 AGAAATTTGA ATTCAAGTCA ACGGATATCT ACAATGATGG ATACGAGACT GTGAGCTGTT 10620 TCCTAACAAC AGATCTCAAA AAATACTGTC TTAATTGGAG ATATGAATCA ACAGCTCTAT 10680 TTGGAGAAAC TTGCAACCAA ATATTTGGAT TAAATAAATT GTTTAATTGG TTACACCCTC 10740 GTCTTGAAGG AAGTACAATC TATGTAGGTG ATCCTTACTG TCCTCCATCA GATAAAGAAC 10800 ATATATCATT AGAGGATCAC CCTGATTCTG GTTTTTACGT TCATAACCCA AGAGGGGGTA 10860 TAGAAGGATT TTGTCAAAAA TTATGGACAC TCATATCTAT AAGTGCAATA CATCTAGCAG 10920 CTGTTAGAAT AGGCGTGAGG GTGACTGCAA TGGTTCAAGG AGACAATCAA GCTATAGCTG 10980 TAACCACAAG AGTACCCAAC AATTATGACT ACAGAGTTAA GAAGGAGATA GTTTATAAAG 11040 ATGTAGTGAG ATTTTTTGAT TCATTAAGAG AAGTGATGGA TGATCTAGGT CATGAACTTA 11100 AATTAAATGA AACGATTATA AGTAGCAAGA TGTTCATATA TAGCAAAAGA ATCTATTATG 11160 ATGGGAGAAT TCTTCCTCAA GCTCTAAAAG CATTATCTAG ATGTGTCTTC TGGTCAGAGA 11220

CAGTAATAGA CGAAACAAGA TCAGCATCTT CAAATTTGGC AACATCATTT GCAAAAGCAA 11280 TTGAGAATGG TTATTCACCT GTTCTAGGAT ATGCATGCTC AATTTTTAAG AACATTCAAC 11340 AACTATATAT TGCCCTTGGG ATGAATATCA ATCCAACTAT AACACAGAAT ATCAGAGATC 11400 AGTATTTTAG GAATCCAAAT TGGATGCAAT ATGCCTCTTT AATACCTGCT AGTGTTGGGG 11460 GATTCAATTA CATGGCCATG TCAAGATGTT TTGTAAGGAA TATTGGTGAT CCATCAGTTG 11520 CCGCATTGGC TGATATTAAA AGATTTATTA AGGCGAATCT ATTAGACCGA AGTGTTCTTT 11580 ATAGGATTAT GAATCAAGAA CCAGGTGAGT CATCTTTTTT GGACTGGGCT TCAGATCCAT 11640 ATTCATGCAA TTTACCACAA TCTCAAAATA TAACCACCAT GATAAAAAAT ATAACAGCAA 11700

GGAATGTATT ACAAGATTCA CCAAATCCAT TATTATCTGG ATTATTCACA AATACAATGA 11760

TAGAAGAAGA TGAAGAATTA GCTGAGTTCC TGATGGACAG GAAGGTAATT CTCCCTAGAG 11820

TTGCACATGA TATTCTAGAT AATTCTCTCA CAGGAATTAG AAATGCCATA GCTGGAATGT 11880

TAGATACGAC AAAATCACTA ATTCGGGTTG GCATAAATAG AGGAGGACTG ACATATAGTT 11940

TGTTGAGGAA AATCAGTAAT TACGATCTAG TACAATATGA AACACTAAGT AGGACTTTGC 12000

GACTAATTGT AAGTGATAAA ATCAAGTATG AAGATATGTG TTCGGTAGAC CTTGCCATAG 12060

CATTGCGACA AAAGATGTGG ATTCATTTAT CAGGAGGAAG GATGATAAGT GGACTTGAAA 12120

CGCCTGACCC ATTAGAATTA CTATCTGGGG TAGTAATAAC AGGATCAGAA CATTGTAAAA 12180

TATGTTATTC TTCAGATGGC ACAAACCCAT ATACTTGGAT GTATTTACCC GGTAATATCA 12240

AAATAGGATC AGCAGAAACA GGTATATCGT CATTAAGAGT TCCTTATTTT GGATCAGTCA 12300

CTGATGAAAG ATCTGAAGCA CAATTAGGAT ATATCAAGAA TCTTAGTAAA CCTGCAAAAG 12360

CCGCAATAAG AATAGCAATG ATATATACAT GGGCATTTGG TAATGATGAG ATATCTTGGA 12420

TGGAAGCCTC ACAGATAGCA CAAACACGTG CAAATTTTAC ACTAGATAGT CTCAAAATTT 12480

TAACACCGGT AGCTACATCA ACAAATTTAT CACACAGATT AAAGGATACT GCAACTCAGA 12540

TGAAATTCTC CAGTACATCA TTGATCAGAG TCAGCAGATT CATAACAATG TCCAATGATA 12600

ACATGTCTAT CAAAGAAGCT AATGAAACCA AAGATACTAA TCTTATTTAT CAACAAATAA 12660

TGTTAACAGG ATTAAGTGTT TTCGAATATT TATTTAGATT AAAAGAAACC ACAGGACACA 12720

ACCCTATAGT TATGCATCTG CACATAGAAG ATGAGTGTTG TATTAAAGAA AGTTTTAATG 12780

ATGAACATAT TAATCCAGAG TCTACATTAG AATTAATTCG ATATCCTGAA AGTAATGAAT 12840

TTATTTATGA TAAAGACCCA CTCAAAGATG TGGACTTATC AAAACTTATG GTTATTAAAG 12900

ACCATTCTTA CACAATTGAT ATGAATTATT GGGATGATAC TGACATCATA CATGCAATTT 12960

CAATATGTAC TGCAATTACA ATAGCAGATA CTATGTCACA ATTAGATCGA GATAATTTAA 13020

AAGAGATAAT AGTTATTGCA AATGATGATG ATATTAATAG CTTAATCACT GAATTTTTGA 13080

CTCTTGACAT ACTTGTATTT CTCAAGACAT TTGGTGGATT ATTAGTAAAT CAATTTGCAT 13140

ACACTCTTTA TAGTCTAAAA ATAGAAGGTA GGGATCTCAT TTGGGATTAT ATAATGAGAA 13200 CACTGAGAGA TACTTCCCAT TCAATATTAA AAGTATTATC TAATGCATTA TCTCATCCTA 13260

AAGTATTCAA GAGGTTCTGG GATTGTGGAG TTTTAAACCC TATTTATGGT CCTAATACTG 13320

CTAGTCAAGA CCAGATAAAA CTTGCCCTAT CTATATGTGA ATATTCACTA GATCTATTTA 13380

TGAGAGAATG GTTGAATGGT GTATCACTTG AAATATACAT TTGTGACAGC GATATGGAAG 13440

TTGCAAATGA TAGGAAACAA GCCTTTATTT CTAGACACCT TTCATTTGTT TGTTGTTTAG 13500

CAGAAATTGC ATCTTTCGGA CCTAACCTGT TAAACTTAAC ATACTTGGAG AGACTTGATC 13560

TATTGAAACA ATATCTTGAA TTAAATATTA AAGAAGACCC TACTCTTAAA TATGTACAAA 13620

TATCTGGATT ATTAATTAAA TCGTTCCCAT CAACTGTAAC ATACGTAAGA AAGACTGCAA 13680

TCAAATATCT AAGGATTCGC GGTATTAGTC CACCTGAGGT AATTGATGAT TGGGATCCGG 13740

TAGAAGATGA AAATATGCTG GATAACATTG TCAAAACTAT AAATGATAAC TGTAATAAAG 13800

ATAATAAAGG GAATAAAATT AACAATTTCT GGGGACTAGC ACTTAAGAAC TATCAAGTCC 13860

TTAAAATCAG ATCTATAACA AGTGATTCTG ATGATAATGA TAGACTAGAT GCTAATACAA 13920

GTGGTTTGAC ACTTCCTCAA GGAGGGAATT ATCTATCGCA TCAATTGAGA TTATTCGGAA 13980

TCAACAGCAC TAGTTGTCTG AAAGCTCTTG AGTTATCACA AATTTTAATG AAGGAAGTCA 14040

ATAAAGACAA GGACAGGCTC TTCCTGGGAG AAGGAGCAGG AGCTATGCTA GCATGTTATG 14100

ATGCCACATT AGGACCTGCA GTTAATTATT ATAATTCAGG TTTGAATATA ACAGATGTAA 14160

TTGGTCAACG AGAATTGAAA ATATTTCCTT CAGAGGTATC ATTAGTAGGT AAAAAATTAG 14220

GAAATGTGAC ACAGATTCTT AACAGGGTAA AAGTACTGTT CAATGGGAAT CCTAATTCAA 14280

CATGGATAGG AAATATGGAA TGTGAGAGCT TAATATGGAG TGAATTAAAT GATAAGTCCA 14340

TTGGATTAGT ACATTGTGAT ATGGAAGGAG CTATCGGTAA ATCAGAAGAA ACTGTTCTAC 14400

ATGAACATTA TAGTGTTATA AGAATTACAT ACTTGATTGG GGATGATGAT GTTGTTTTAG 14460

TTTCCAAAAT TATACCTACA ATCACTCCGA ATTGGTCTAG AATACTTTAT CTATATAAAT 14520

TATATTGGAA AGATGTAAGT ATAATATCAC TCAAAACTTC TAATCCTGCA TCAACAGAAT 14580

TATATCTAAT TTCGAAAGAT GCATATTGTA CTATAATGGA ACCTAGTGAA ATTGTTTTAT 14640

CAAAACTTAA AAGATTGTCA CTCTTGGAAG AAAATAATCT ATTAAAATGG ATCATTTTAT 14700

CAAAGAAGAG GAATAATGAA TGGTTACATC ATGAAATCAA AGAAGGAGAA AGAGATTATG 14760 GAATCATGAG ACCATATCAT ATGGCACTAC AAATCTTTGG ATTTCAAATC AATTTAAATC 14820

ATCTGGCGAA AGAATTTTTA TCAACCCCAG ATCTGACTAA TATCAACAAT ATAATCCAAA 14880

GTTTTCAGCG AACAATAAAG GATGTTTTAT TTGAATGGAT TAATATAACT CATGATGATA 14940

AGAGACATAA ATTAGGCGGA AGATATAACA TATTCCCACT GAAAAATAAG GGAAAGTTAA 15000

GACTGCTATC GAGAAGACTA GTATTAAGTT GGATTTCATT ATCATTATCG ACTCGATTAC 15060

TTACAGGTCG CTTTCCTGAT GAAAAATTTG AACATAGAGC ACAGACTGGA TATGTATCAT 15120

TAGCTGATAC TGATTTAGAA TCATTAAAGT TATTGTCGAA AAACATCATT AAGAATTACA 15180

GAGAGTGTAT AGGATCAATA TCATATTGGT TTCTAACCAA AGAAGTTAAA ATACTTATGA 15240

AATTGATTGG TGGTGCTAAA TTATTAGGAA TTCCCAGACA ATATAAAGAA CCCGAAGACC 15300

AGTTATTAGA AAACTACAAT CAACATGATG AATTTGATAT CGATTAAAAC ATAAATACAA 15360

TGAAGATATA TCCTAACCTT TATCTTTAAG CCTAGGAATA GACAAAAAGT AAGAAAAACA 15420

TGTAATATAT ATATACCAAA CAGAGTTCTT CTCTTGTTTG GT 15462 (2) INFORMATION FOR SEQ ID NO: 18:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2233 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii ) MOLECULE TYPE : protein

(xi ) SEQUENCE DESCRIPTION : SEQ ID NO : 18 :

Met Asp Thr Glu Ser Asn Asn Gly Thr Val Ser Asp He Leu Tyr Pro 1 5 10 15

Glu Cys His Leu Asn Ser Pro He Val Lys Gly Lye He Ala Gin Leu 20 25 30

His Thr He Met Ser Leu Pro Gin Pro Tyr Aβp Met Asp Asp Asp Ser 35 40 45

He Leu Val He Thr Arg Gin Lys He Lys Leu Asn Lys Leu Asp Lys 50 55 60 Arg Gin Arg Ser He Arg Arg Leu Lys Leu He Leu Thr Glu Lye Val 65 70 75 80

Asn Asp Leu Gly Lys Tyr Thr Phe He Arg Tyr Pro Glu Met Ser Lys 85 90 95

Glu Met Phe Lys Leu Tyr He Pro Gly He Aβn Ser Lys Val Thr Glu 100 105 110

Leu Leu Leu Lys Ala Asp Arg Thr Tyr Ser Gin Met Thr Asp Gly Leu 115 120 125

Arg Asp Leu Trp He Aβn Val Leu Ser Lys Leu Ala Ser Lys Asn Asp 130 135 140

Gly Ser Asn Tyr Asp Leu Asn Glu Glu He Asn Asn He Ser Lye Val 145 150 155 160

Hiβ Thr Thr Tyr Lye Ser Aβp Lys Trp Tyr Asn Pro Phe Lys Thr Trp 165 170 175

Phe Thr He Lys Tyr Asp Met Arg Arg Leu Gin Lys Ala Arg Asn Glu 180 185 190

He Thr Phe Asn Val Gly Lys Asp Tyr Asn Leu Leu Glu Asp Gin Lys 195 200 205

Aβn Phe Leu Leu He His Pro Glu Leu Val Leu He Leu Asp Lys Gin 210 215 220

Aβn Tyr Aβn Gly Tyr Leu He Thr Pro Glu Leu Val Leu Met Tyr Cyβ 225 230 235 240

Aβp Val Val Glu Gly Arg Trp Aβn He Ser Ala Cys Ala Lys Leu Asp 245 250 255

Pro Lys Leu Gin Ser Met Tyr Gin Lys Gly Asn Asn Leu Trp Glu Val 260 265 270

He Aβp Lye Leu Phe Pro He Met Gly Glu Lye Thr Phe Asp Val He 275 280 285

Ser Leu Leu Glu Pro Leu Ala Leu Ser Leu He Gin Thr His Asp Pro 290 295 300

Val Lys Gin Leu Arg Gly Ala Phe Leu Asn His Val Leu Ser Glu Met 305 310 315 320

Glu Leu He Phe Glu Ser Arg Glu Ser He Lys Glu Phe Leu Ser Val 325 330 335

Asp Tyr He Asp Lys He Leu Asp He Phe Asn Lys Ser Thr He Asp 340 345 350

Glu He Ala Glu He Phe Ser Phe Phe Arg Thr Phe Gly Hiβ Pro Pro 355 360 365

Leu Glu Ala Ser He Ala Ala Glu Lys Val Arg Lys Tyr Met Tyr He 370 375 380

Gly Lys Gin Leu Lys Phe Asp Thr He Asn Lys Cyβ His Ala He Phe 385 390 395 400

Cys Thr He He He Asn Gly Tyr Arg. Glu Arg His Gly Gly Gin Trp 405 410 415

Pro Pro Val Thr Leu Pro Aβp His Ala His Glu Phe He He Asn Ala 420 425 430

Tyr Gly Ser Asn Ser Ala He Ser Tyr Glu Asn Ala Val Asp Tyr Tyr 435 440 445

Gin Ser Phe He Gly He Lys Phe Asn Lys Phe He Glu Pro Gin Leu 450 455 460

Asp Glu Asp Leu Thr He Tyr Met Lys Aβp Lys Ala Leu Ser Pro Lys 465 470 475 480

Lys Ser Asn Trp Aβp Thr Val Tyr Pro Ala Ser Aβn Leu Leu Tyr Arg 485 490 495

Thr Aβn Ala Ser Aβn Glu Ser Arg Arg Leu Val Glu Val Phe He Ala 500 505 510

Aβp Ser Lys Phe Asp Pro His Gin He Leu Asp Tyr Val Glu Ser Gly 515 520 525

Asp Trp Leu Asp Asp Pro Glu Phe Asn He Ser Tyr Ser Leu Lys Glu 530 535 540

Lys Glu He Lys Gin Glu Gly Arg Leu Phe Ala Lys Met Thr Tyr Lys 545 550 555 560

Met Arg Ala Thr Gin Val Leu Ser Glu Thr Leu Leu Ala Asn Asn He 565 570 575

Gly Lys Phe Phe Gin Glu Asn Gly Met Val Lys Gly Glu He Glu Leu 580 585 590

Leu Lys Arg Leu Thr Thr He Ser He Ser Gly Val Pro Arg Tyr Asn 595 600 605

Glu Val Tyr Asn Aβn Ser Lye Ser His Thr Asp Aβp Leu Lys Thr Tyr 610 615 620 Asn Lys He Ser Asn Leu Asn Leu Ser Ser Asn Gin Lys Ser Lys Lys 625 630 635 640

Phe Glu Phe Lys Ser Thr Asp He Tyr Asn Asp Gly Tyr Glu Thr Val 645 650 655

Ser Cys Phe Leu Thr Thr Aβp Leu Lye Lye Tyr Cyβ Leu Aβn Trp Arg 660 665 670

Tyr Glu Ser Thr Ala Leu Phe Gly Glu Thr Cyβ Aβn Gin He Phe Gly 675 680 685

Leu Aβn Lye Leu Phe Aβn Trp Leu Hiβ Pro Arg Leu Glu Gly Ser Thr 690 695 700

He Tyr Val Gly Asp Pro Tyr Cys Pro Pro Ser Asp Lys Glu His He 705 710 715 720

Ser Leu Glu Asp His Pro Aβp Ser Gly Phe Tyr Val His Asn Pro Arg 725 730 735

Gly Gly He Glu Gly Phe Cys Gin Lys Leu Trp Thr Leu He Ser He 740 745 750

Ser Ala He His Leu Ala Ala Val Arg He Gly Val Arg Val Thr Ala 755 760 765

Met Val Gin Gly Asp Asn Gin Ala He Ala Val Thr Thr Arg Val Pro 770 775 780

Asn Asn Tyr Asp Tyr Arg Val Lys Lys Glu He Val Tyr Lys Asp Val 785 790 795 800

Val Arg Phe Phe Asp Ser Leu Arg Glu Val Met Asp Asp Leu Gly Hiβ 805 810 815

Glu Leu Lye Leu Asn Glu Thr He He Ser Ser Lye Met Phe He Tyr 820 825 830

Ser Lye Arg He Tyr Tyr Asp Gly Arg He Leu Pro Gin Ala Leu Lys 835 840 845

Ala Leu Ser Arg Cyβ Val Phe Trp Ser Glu Thr Val He Asp Glu Thr 850 855 860

Arg Ser Ala Ser Ser Asn Leu Ala Thr Ser Phe Ala Lys Ala He Glu 865 870 875 880

Asn Gly Tyr Ser Pro Val Leu Gly Tyr Ala Cys Ser He Phe Lys Asn 885 890 895 He Gin Gin Leu Tyr He Ala Leu Gly Met Asn He Asn Pro Thr He 900 905 910

Thr Gin Asn He Arg Asp Gin Tyr Phe Arg Asn Pro Aβn Trp Met Gin 915 920 925

Tyr Ala Ser Leu He Pro Ala Ser Val Gly Gly Phe Aβn Tyr Met Ala 930 935 940

Met Ser Arg Cyβ Phe Val Arg Aβn He Gly Asp Pro Ser Val Ala Ala 945 950 955 960

Leu Ala Asp He Lye Arg Phe He Lye Ala Aβn Leu Leu Aβp Arg Ser 965 970 975

Val Leu Tyr Arg He Met Aen Gin Glu Pro Gly Glu Ser Ser Phe Leu 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Cys Aβn Leu Pro Gin Ser Gin Aβn 995 1000 1005

He Thr Thr Met He Lye Aβn He Thr Ala Arg Aβn Val Leu Gin Aβp 1010 1015 1020

Ser Pro Aβn Pro Leu Leu Ser Gly Leu Phe Thr Aβn Thr Met He Glu 1025 1030 1035 1040

Glu Aβp Glu Glu Leu Ala Glu Phe Leu Met Asp Arg Lye Val He Leu 1045 1050 1055

Pro Arg Val Ala Hiβ Asp He Leu Asp Asn Ser Leu Thr Gly He Arg 1060 1065 1070

Asn Ala He Ala Gly Met Leu Asp Thr Thr Lys Ser Leu He Arg Val 1075 1080 1085

Gly He Asn Arg Gly Gly Leu Thr Tyr Ser Leu Leu Arg Lys He Ser 1090 1095 1100

Asn Tyr Asp Leu Val Gin Tyr Glu Thr Leu Ser Arg Thr Leu Arg Leu 1105 1110 1115 1120

He Val Ser Asp Lys He Lys Tyr Glu Asp Met Cys Ser Val Asp Leu 1125 1130 1135

Ala He Ala Leu Arg Gin Lys Met Trp He Hiβ Leu Ser Gly Gly Arg 1140 1145 1150

Met He Ser Gly Leu Glu Thr Pro Aβp Pro Leu Glu Leu Leu Ser Gly 1155 1160 1165

Val Val He Thr Gly Ser Glu Hie Cys Lys He Cys Tyr Ser Ser Asp 1170 1175 1180

Gly Thr Asn Pro Tyr Thr Trp Met Tyr Leu Pro Gly Asn He Lys He 1185 1190 1195 1200

Gly Ser Ala Glu Thr Gly He Ser Ser Leu Arg Val Pro Tyr Phe Gly 1205 1210 1215

Ser Val Thr Asp Glu Arg Ser Glu Ala Gin Leu Gly Tyr He Lye Aen 1220 1225 1230

Leu Ser Lys Pro Ala Lys Ala Ala He Arg He Ala Met He Tyr Thr 1235 1240 1245

Trp Ala Phe Gly Asn Asp Glu He Ser Trp Met Glu Ala Ser Gin He 1250 1255 1260

Ala Gin Thr Arg Ala Asn Phe Thr Leu Asp Ser Leu Lys He Leu Thr 1265 1270 1275 1280

Pro Val Ala Thr Ser Thr Asn Leu Ser His Arg Leu Lys Asp Thr Ala 1285 1290 1295

Thr Gin Met Lys Phe Ser Ser Thr Ser Leu He Arg Val Ser Arg Phe 1300 1305 1310

He Thr Met Ser Asn Asp Asn Met Ser He Lys Glu Ala Asn Glu Thr 1315 1320 1325

Lys Asp Thr Asn Leu He Tyr Gin Gin He Met Leu Thr Gly Leu Ser 1330 1335 1340

Val Phe Glu Tyr Leu Phe Arg Leu Lys Glu Thr Thr Gly His Asn Pro 1345 1350 1355 1360

He Val Met His Leu His He Glu Asp Glu Cys Cys He Lys Glu Ser 1365 1370 1375

Phe Asn Asp Glu His He Asn Pro Glu Ser Thr Leu Glu Leu He Arg 1380 1385 1390

Tyr Pro Glu Ser Asn Glu Phe He Tyr Asp Lys Aβp Pro Leu Lye Aep 1395 1400 1405

Val Aβp Leu Ser Lye Leu Met Val He Lys Asp His Ser Tyr Thr He 1410 1415 1420

Asp Met Asn Tyr Trp Asp Asp Thr Asp He He His Ala He Ser He 1425 1430 1435 1440

Cys Thr Ala He Thr He Ala Asp Thr Met Ser Gin Leu Asp Arg Aβp 1445 1450 1455 Asn Leu Lys Glu He He Val He Ala Asn Aβp Asp Asp He Aβn Ser 1460 1465 1470

Leu He Thr Glu Phe Leu Thr Leu Asp He Leu Val Phe Leu Lys Thr 1475 1480 1485

Phe Gly Gly Leu Leu Val Asn Gin Phe Ala Tyr Thr Leu Tyr Ser Leu 1490 1495 1500

Lys He Glu Gly Arg Asp Leu He Trp Asp Tyr He Met Arg Thr Leu 1505 1510 1515 1520

Arg Aβp Thr Ser Hiβ Ser He Leu Lye Val Leu Ser Aβn Ala Leu Ser 1525 1530 1535

Hiβ Pro Lye Val Phe Lys Arg Phe Trp Asp Cys Gly Val Leu Asn Pro 1540 1545 1550

He Tyr Gly Pro Aβn Thr Ala Ser Gin Aβp Gin He Lys Leu Ala Leu 1555 1560 1565

Ser He Cys Glu Tyr Ser Leu Asp Leu Phe Met Arg Glu Trp Leu Asn 1570 1575 1580

Gly Val Ser Leu Glu He Tyr He Cys Asp Ser Asp Met Glu Val Ala 1585 1590 1595 1600

Aβn Asp Arg Lys Gin Ala Phe He Ser Arg His Leu Ser Phe Val Cys 1605 1610 1615

Cys Leu Ala Glu He Ala Ser Phe Gly Pro Asn Leu Leu Asn Leu Thr 1620 1625 1630

Tyr Leu Glu Arg Leu Asp Leu Leu Lys Gin Tyr Leu Glu Leu Asn He 1635 1640 1645

Lys Glu Aβp Pro Thr Leu Lys Tyr Val Gin He Ser Gly Leu Leu He 1650 1655 1660

Lys Ser Phe Pro Ser Thr Val Thr Tyr Val Arg Lys Thr Ala He Lys 1665 1670 1675 1680

Tyr Leu Arg He Arg Gly He Ser Pro Pro Glu Val He Asp Asp Trp 1685 1690 1695

Asp Pro Val Glu Aβp Glu Asn Met Leu Asp Asn He Val Lys Thr He 1700 1705 1710

Asn Asp Asn Cys Aβn Lys Aβp Aβn Lye Gly Aβn Lye He Aβn Aβn Phe 1715 1720 1725 Trp Gly Leu Ala Leu Lys Aβn Tyr Gin Val Leu Lys He Arg Ser He 1730 1735 1740

Thr Ser Asp Ser Aβp Aβp Aβn Aβp Arg Leu Aβp Ala Aβn Thr Ser Gly 1745 1750 1755 1760

Leu Thr Leu Pro Gin Gly Gly Asn Tyr Leu Ser His Gin Leu Arg Leu 1765 1770 1775

Phe Gly He Asn Ser Thr Ser Cys Leu Lys Ala Leu Glu Leu Ser Gin 1780 1785 1790

He Leu Met Lys Glu Val Asn Lye Aβp Lye Asp Arg Leu Phe Leu Gly 1795 1800 1805

Glu Gly Ala Gly Ala Met Leu Ala Cys Tyr Asp Ala Thr Leu Gly Pro 1810 1815 1820

Ala Val Asn Tyr Tyr Asn Ser Gly Leu Asn He Thr Aβp Val He Gly 1825 1830 1835 1840

Gin Arg Glu Leu Lye He Phe Pro Ser Glu Val Ser Leu Val Gly Lye 1845 1850 1855

Lye Leu Gly Aen Val Thr Gin He Leu Aβn Arg Val Lye Val Leu Phe 1860 1865 1870

Asn Gly Asn Pro Asn Ser Thr Trp He Gly Asn Met Glu Cys Glu Ser 1875 1880 1885

Leu He Trp Ser Glu Leu Asn Asp Lys Ser He Gly Leu Val His Cys 1890 1895 1900

Asp Met Glu Gly Ala He Gly Lys Ser Glu Glu Thr Val Leu Hiβ Glu 1905 1910 1915 1920

His Tyr Ser Val He Arg He Thr Tyr Leu He Gly Asp Aβp Aβp Val 1925 1930 1935

Val Leu Val Ser Lys He He Pro Thr He Thr Pro Asn Trp Ser Arg 1940 1945 1950

He Leu Tyr Leu Tyr Lys Leu Tyr Trp Lys Asp Val Ser He He Ser 1955 1960 1965

Leu Lys Thr Ser Asn Pro Ala Ser Thr Glu Leu Tyr Leu He Ser Lye 1970 1975 1980

Aβp Ala Tyr Cyβ Thr He Met Glu Pro Ser Glu He Val Leu Ser Lye 1985 1990 1995 2000

Leu Lys Arg Leu Ser Leu Leu Glu Glu Asn Asn Leu Leu Lys Trp He 2005 2010 2015

He Leu Ser Lys Lys Arg Asn Asn Glu Trp Leu Hiβ His Glu He Lys 2020 2025 2030

Glu Gly Glu Arg Asp Tyr Gly He Met Arg Pro Tyr His Met Ala Leu 2035 2040 2045

Gin He Phe Gly Phe Gin He Asn Leu Asn His Leu Ala Lys Glu Phe 2050 2055 2060

Leu Ser Thr Pro Asp Leu Thr Aβn He Aβn Aβn He He Gin Ser Phe 2065 2070 2075 2080

Gin Arg Thr He Lye Aβp Val Leu Phe Glu Trp He Asn He Thr His 2085 2090 2095

Asp Asp Lys Arg Hiβ Lye Leu Gly Gly Arg Tyr Aβn He Phe Pro Leu 2100 2105 2110

Lye Aβn Lye Gly Lye Leu Arg Leu Leu Ser Arg Arg Leu Val Leu Ser 2115 2120 2125

Trp He Ser Leu Ser Leu Ser Thr Arg Leu Leu Thr Gly Arg Phe Pro 2130 2135 2140

Aβp Glu Lye Phe Glu Hiβ Arg Ala Gin Thr Gly Tyr Val Ser Leu Ala 2145 2150 2155 2160

Aβp Thr Aβp Leu Glu Ser Leu Lys Leu Leu Ser Lys Asn He He Lys 2165 2170 2175

Asn Tyr Arg Glu Cys He Gly Ser He Ser Tyr Trp Phe Leu Thr Lys 2180 2185 2190

Glu Val Lys He Leu Met Lys Leu He Gly Gly Ala Lys Leu Leu Gly 2195 2200 2205

He Pro Arg Gin Tyr Lys Glu Pro Glu Asp Gin Leu Leu Glu Asn Tyr 2210 2215 2220

Aβn Gin Hie Aβp Glu Phe Aβp He Aβp 2225 2230

(2) INFORMATION FOR SEQ ID NO: 19:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15462 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear (ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 19:

ACCAAACAAG AGAAGAAACT TGCTTGGTAA TATAAATTTA ACTTAAAATT AACTTAGGAT 60

TTAAGACATT GACTAGAAGG TCAAGAAAAG GGAACTCTAT AATTTCAAAA ATGTTGAGCC 120

TATTTGATAC ATTTAATGCA CGTAGGCAAG AAAACATAAC AAAATCAGCC GGTGGAGCTA 180

TCATTCCTGG ACAGAAAAAT ACTGTCTCTA TATTCGCCCT TGGACCGACA ATAACTGATG 240

ATAATGAGAA AATGACATTA GCTCTTCTAT TTCTATCTCA TTCACTAGAT AATGAGAAAC 300

AACATGCACA AAGGGCAGGG TTCTTGGTGT CTTTATTGTC AATGGCTTAT GCCAATCCAG 360

AGCTCTACCT AACAACAAAT GGAAGTAATG CAGATGCCAA GTATGTCATA TACATGATTG 420

AGAAAGATCT AAAACGGCAA AAGTATGGAG GATTTGTGGT TAAGACGAGA GAGATGATAT 480

ATGAAAAGAC AACTGATTGG ATATTTGGAA GTGACCTGGA TTATGATCAG GAAACTATGT 540

TGCAGAACGG CAGGAACAAT TCAACAATTG AAGACCTTGT CCACACATTT GGGTATCCAT 600

CATGTTTAGG AGCTCTTATA ATACAGATCT GGATAGTTCT GGTCAAAGCT ATCACTAGTA 660

TCTCAGGGTT AAGAAAAGGC TTTTTCACCC GATTGGAAGC TTTCAGACAA GATGGAACAG 720

TGCAGGCAGG GCTGGTATTG AGCGGTGACA CAGTGGATCA GATTGGGTCA ATCATGCGGT 780

CTCAACAGAG CTTGGTAACT CTTATGGTTG AAACATTAAT AACAATGAAT ACCAGCAGAA 840

ATGACCTCAC AACCATAGAA AAGAATATAC AAATTGTTGG CAACTACATA AGAGATGCAG 900

GTCTCGCTTC ATTCTTCAAT ACAATCAGAT ATGGAATTGA GACCAGAATG GCAGCTTTGA 960

CTCTATCCAC TCTCAGACCA GATATCAATA GATTAAAAGC TTTGATGGAA CTGTATTTAT 1020

CAAAGGGACC ACGCGCTCCT TTCATCTGTA TCCTCAGAGA TCCTATACAT GGTGAGTTCG 1080

CACCAGGCAA CTATCCTGCC ATATGGAGCT ATGCAATGGG GGTGGCAGTT GTACAAAATA 1140

GAGCCATGCA ACAGTATGTG ACGGGAAGAT CATATCTAGA CATTGATATG TTCCAGCTAG 1200

GACAAGCAGT AGCACGTGAT GCCGAAGCTC AAATGAGCTC AACACTGGAA GATGAACTTG 1260

GAGTGACACA CGAAGCTAAA GAAAGCTTGA AGAGACATAT AAGGAACATA AACAGTTCAG 1320

AGACATCTTT CCACAAACCG ACAGGTGGAT CAGCCATAGA GATGGCAATA GATGAAGAGC 1380 CAGAACAATT CGAACATAGA GCAGATCAAG AACAAAATGG AGAACCTCAA TCATCCATAA 1440

TTCAATATGC CTGGGCAGAA GGAAATAGAA GCGATGATCA GACTGAGCAA GCTACAGAAT 1500

CTGACAATAT CAAGACCGAA CAACAAAACA TCAGAGACAG ACTAAACAAG AGACTCAACG 1560

ACAAGAAGAA ACAAAGCAGT CAACCACCCA CTAATCCCAC AAACAGAACA AACCAGGACG 1620

AAATAGATGA TCTGTTTAAC GCATTTGGAA GCAACTAATC GAATCAACAT TTTAATCTAA 1680

ATCAATAATA AATAAGAAAA ACTTAGGATT AAAGAATCCT ATCATACCGG AATATAGGGT 1740

GGTAAATTTA GAGTCTGCTT GAAACTCAAT CAATAGAGAG TTGATGGAAA GCGATGCTAA 1800

AAACTATCAA ATCATGGATT CTTGGGAAGA GGAATCAAGA GATAAATCAA CTAATATCTC 1860

CTcσσcccTc AACATCATTG AATTCATACT CAGCACCGAC CCCCAAGAAG ACTTATCGGA 1920

AAACGACACA ATCAACACAA GAACCCAGCA ACTCAGTGCC ACCATCTGTC AACCAGAAAT 1980

CAAACCAACA GAAACAAGTG AGAAAGATAG TGGATCAACT GACAAAAATA GACAGTCTGG 2040

GTCATCACAC GAATGTACAA CAGAAGCAAA AGATAGAAAC ATTGATCAGG AAACTGTACA 2100

GAGAGGACCT GGGAGAAGAA GCAGCTCAGA TAGTAGAGCT GAGACTGTGG TCTCTGGAGG 2160

AATCCCCAGA AGCATCACAG ATTCTAAAAA TGGAACCCAA AACACGGAGG ATATTGATCT 2220

CAATGAAATT AGAAAGATGG ATAAGGACTC TATTGAGGGG AAAATGCGAC AATCTGCAAA 2280

TGTTCCAAGC GAGATATCAG GAAGTGATGA CATATTTACA ACAGAACAAA GTAGAAACAG 2340

TGATCATGGA AGAAGCCTGG AATCTATCAG TACACCTGAT ACAAGATCAA TAAGTGTTGT 2400

TACTGCTGCA ACACCAGATG ATGAAGAAGA AATACTAATG AAAAATAGTA GGACAAAGAA 2460

AAGTTCTTCA ACACATCAAG AAGATGACAA AAGAATTAAA AAAGGGGGAA AAGGGAAAGA 2520

CTGGTTTAAG AAATCAAAAG ATACCGACAA CCAGATACCA ACATCAGACT ACAGATCCAC 2580

ATCAAAAGGG CAGAAGAAAA TCTCAAAGAC AACAACCACC AACACCGACA CAAAGGGGCA 2640

AACAGAAATA CAGACAGAAT CATCAGAAAC ACAATCCTCA TCATGGAATC TCATCATCGA 2700

CAACAACACC GACCGGAACG AACAGACAAG CACAACTCCT CCAACAACAA CTTCCAGATC 2760

AACTTATACA AAAGAATCGA TCCGAACAAA CTCTGAATCC AAACCCAAGA CACAAAAGAC 2820

AAATGGAAAG GAAAGGAAGG ATACAGAAGA GAGCAATCGA TTTACAGAGA GGGCAATTAC 2880

TCTATTGCAG AATCTTGGTG TAATTCAATC CACATCAAAA CTAGATTTAT ATCAAGACAA 2940 ACGAGTTGTA TGTGTAGCAA ATGTACTAAA CAATGTAGAT ACTGCATCAA AGATAGATTT 3000

CCTGGCAGGA TTAGTCATAG GGGTTTCAAT GGACAACGAC ACAAAATTAA CACAGATACA 3060

AAATGAAATG CTAAACCTCA AAGCAGATCT AAAGAAAATG GACGAATCAC ATAGAAGATT 3120

GATAGAAAAT CAAAGAGAAC AACTGTCATT GATCACGTCA CTAATTTCAA ATCTCAAAAT 3180

TATGACTGAG AGAGGAGGAA AGAAAGACCA AAATGAATCC AATGAGAGAG TATCCATGAT 3240

CAAAACAAAA TTGAAAGAAG AAAAGATCAA GAAGACCAGG TTTGACCCAC TTATGGAGGC 3300

ACAAGGCATT GACAAGAATA TACCCGATCT ATATCGACAT GCAGGAGATA CACTAGAGAA 3360

CGATGTACAA GTTAAATCAG AGATATTAAG TTCATACAAT GAGTCAAATG CAACAAGACT 3420

AATACCCAAA AAAGTGAGCA GTACAATGAG ATCACTAGTT GCAGTCATCA ACAACAGCAA 3480

TCTCTCACAA AGCACAAAAC AATCATACAT AAACGAACTC AAACGTTGCA AAAATGATGA 3540

AGAAGTATCT GAATTAATGG ACATGTTCAA TGAAGATGTC AACAATTGCC AATGATCCAA 3600

CAAAGAAACG ACACCGAACA AACAGACAAG AAACAACAGT AGATCAAAAC CTGTCAACAC 3660

ACACAAAATC AAGCAGAATG AAACAACAGA TATCAATCAA TATACAAATA AGAAAAACTT 3720

AGGATTAAAG AATAAATTAA TCCTTGTCCA AAATGAGTAT AACTAACTCT GCAATATACA 3780

CATTCCCAGA ATCATCATTC TCTGAAAATG GTCATATAGA ACCATTACCA CTCAAAGTCA 3840

ATGAACAGAG GAAAGCAGTA CCCCACATTA GAGTTGCCAA GATCGGAAAT CCACCAAAAC 3900

ACGGATCCCG GTATTTAGAT GTCTTCTTAC TCGGCTTCTT CGAGATGGAA CGAATCAAAG 3960

ACAAATACGG GAGTGTGAAT GATCTCGACA GTGACCCGAG TTACAAAGTT TGTGGCTCTG 4020

GATCATTACC AATCGGATTG GCTAAGTACA CTGGGAATGA CCAGGAATTG TTACAAGCCG 4080

CAACCAAACT GGATATAGAA GTGAGAAGAA CAGTCAAAGC GAAAGAGATG GTTGTTTACA 4140

CGGTACAAAA TATAAAACCA GAACTGTACC CATGGTCCAA TAGACTAAGA AAAGGAATGC 4200

TGTTCGATGC CAACAAAGTT GCTCTTGCTC CTCAATGTCT TCCACTAGAT AGGAGCATAA 4260

AATTTAGAGT AATCTTCGTG AATTGTACGG CAATTGGATC AATAACCTTG TTCAAAATTC 4320

CTAAGTCAAT GGCATCACTA TCTCTAACCA ACACAATATC AATCAATCTG CAGGTACACA 4380

TAAAAACAGG GGTTCAGACT GATTCTAAAG GGATAGTTCA AATTTTGGAT GAGAAAGGCG 4440

AAAAATCACT GAATTTCATG GTCCATCTCG GATTGATCAA AAGAAAAGTA GGCAGAATGT 4500 ACTCTGTTGA ATACTGTAAA CAGAAAATCβ AGAAAATGAG ATTGATATTT TCTTTAGGAC 4560

TAGTTGGAGG AATCAGTCTT CATGTCAATG CAACTGGGTC CATATCAAAA ACACTAGCAA 4620

GTCAGCTGGT ATTCAAAAGA GAGATTTGTT ATCCTTTAAT GGATCTAAAT CCGCATCTCA 4680

ATCTAGTTAT CTGGGCTTCA TCAGTAGAGA TTACAAGAGT GGATGCAATT TTCCAACCTT 4740

CTTTACCTGG CGAGTTCAGA TACTATCCTA ATATTATTGC AAAAGGAGTT GGGAAAATCA 4800

AACAATGGAA CTAGTAATCT CTATTTTAGT CCGGACGTAT CTATTAAGCC GAAGCAAATA 4860

AAGGATAATC AAAAACTTAG GACAAAAGAG GTCAATACCA ACAACTATTA GCAGTCACAC 4920

TCGCAAGAAT AAGAGAGAAG GGACCAAAAA AGTCAAATAG GAGAAATCAA AACAAAAGGT 4980

ACAGAACACC AGAACAACAA AATCAAAACA TCCAACTCAC TCAAAACAAA AATTCCAAAA 5040

GAGACCGGCA ACACAACAAG CACTGAACAC AATGCCAACT TCAATACTGC TAATTATTAC 5100

AACCATGATC ATGGCATCTT TCTGCCAAAT AGATATCACA AAACTACAGC ACGTAGGTGT 5160

ATTGGTCAAC AGTCCCAAAG GGATGAAGAT ATCACAAAAC TTTGAAACAA GATATCTAAT 5220

TTTGAGCCTC ATACCAAAAA TAGAAGACTC TAACTCTTGT GGTGACCAAC AGATCAAGCA 5280

ATACAAGAAG TTATTGGATA GACTGATCAT CCCTTTATAT GATGGATTAA GATTACAGAA 5340

AGATGTGATA GTAACCAATC AAGAATCCAA TGAAAACACT GATCCCAGAA CAAAACGATT 5400

CTTTGGAGGG GTAATTGGAA CCATTGCTCT GGGAGTAGCA ACCTCAGCAC AAATTACAGC 5460

GGCAGTTGCT CTGGTTGAAG CCAAGCAGGC AAGATCAGAC ATCGAAAAAC TCAAAGAAGC 5520

AATTAGGGAC ACAAATAAAG CAGTGCAGTC AGTTCAGAGC TCCATAGGAA ATTTAATAGT 5580

AGCAATTAAA TCAGTCCAGG ATTATGTTAA CAAAGAAATC GTGCCATCGA TTGCGAGGCT 5640

AGGTTGTGAA GCAGCAGGAC TTCAATTAGG AATTGCATTA ACACAGCATT ACTCAGAATT 5700

AACAAACATA TTTGGTGATA ACATAGGATC GTTACAAGAA AAAGGAATAA AATTACAAGG 57 0

TATAGCATCA TTATACCGCA CAAATATCAC AGAAATATTC ACAACATCAA CAGTTGATAA 5820

ATATGATATC TATGATCTGT TATTTACAGA ATCAATAAAG GTGAGAGTTA TAGATGTTGA 5880

CTTGAATGAT TACTCAATCA CCCTCCAAGT CAGACTCCCT TTATTAACTA GGCTGCTGAA 5940

CACTCAGATC TACAAAGTAG ATTCCATATC ATATAACATC CAAAACAGAG AATGGTATAT 6000

CCCTCTTCCC AGCCATATCA TGACGAAAGG GGCATTTCTA GGTGGAGCAG ACGTCAAAGA 6060 ATGTATAGAA GCATTCAGCA GCTATATATG CCCTTCTGAT CCAGGATTTG TATTAAACCA 6120

TGAAATAGAG AGCTGCTTAT CAGGAAACAT ATCCCAATGT CCAAGAACAA CGGTCACATC 6180

AGACATTGTT CCAAGATATG CATTTGTCAA TGGAGGAGTG GTTGCAAACT GTATAACAAC 6240

CACCTGTACA TGCAACGGAA TTGGTAATAG AATCAATCAA CCACCTGATC AAGGAGTAAA 6300

AATTATAACA CATAAAGAAT GTAGTACAGT AGGTATCAAC GGAATGCTGT TCAATACAAA 6360

TAAAGAAGGA ACTCTTGCAT TCTATACACC AAATGATATA ACACTAAACA ATTCTGTTAC 6420

ACTTGATCCA ATTGACATAT CAATCGAGCT CAACAAGGCC AAATCAGATC TAGAAGAATC 6480

AAAAGAATGG ATAAGAAGGT CAAATCAAAA ACTAGATTCT ATTGGAAATT GGCATCAATC 6540

TAGCACTACA ATCATAATTA TTTTGATAAT GATCATTATA TTGTTTATAA TTAATATAAC 6600

GATAATTACA ATTGCAATTA AGTATTACAG AATTCAAAAG AGAAATCGAG TGGATCAAAA 6660

TGACAAGCCA TATGTACTAA CAAACAAATA ACATATCTAC AGATCATTAG ATATTAAAAT 6720

TATAAAAAAC TTAGGAGTAA AGTTACGCAA TCCAACTCTA CTCATATAAT TGAGGAAGGA 6780

CCCAATAGAC AAATCCAAAT TCGAGATGGA ATACTGGAAG CATACCAATC ACGGAAAGGA 6840

TGCTGGCAAT GAGCTGGAGA CGTCTATGGC TACTCATGGC AACAAGCTCA CTAATAAGAT 6900

AATATACATA TTATGGACAA TAATCCTGGT GTTATTATCA ATAGTCTTCA TCATAGTGCT 6960

AATTAATTCC ATCAAAAGTG AAAAGGCCCA CGAATCATTG CTGCAAGACA TAAATAATGA 7020

GTTTATGGAA ATTACAGAAA AGATCCAAAT GGCATCGGAT AATACCAATG ATCTAATACA 7080

GTCAGGAGTG AATACAAGGC TTCTTACAAT TCAGAGTCAT GTCCAGAATT ACATACCAAT 7140

ATCATTGACA CAACAGATGT CAGATCTTAG GAAATTCATT AGTGAAATTA CAATTAGAAA 7200

TGATAATCAA GAAGTGCTGC CACAAAGAAT AACACATGAT GTAGGTATAA AACCTTTAAA 7260

TCCAGATGAT TTTTGGAGAT GCACGTCTGG TCTTCCATCT TTAATGAAAA CTCCAAAAAT 7320

AAGGTTAATG CCAGGGCCGG GATTATTAGC TATGCCAACG ACTGTTGATG GCTGTGTTAG 7380

AACTCCGTCT TTAGTTATAA ATGATCTGAT TTATGCTTAT ACCTCAAATC TAATTACTCG 7440

AGGTTGTCAG GATATAGGAA AATCATATCA AGTCTTACAG ATAGGGATAA TAACTGTAAA 7500

CTCAGACTTG GTACCTGACT TAAATCCTAG GATCTCTCAT ACCTTTAACA TAAATGACAA 7560

TAGGAAGTCA TGTTCTCTAG CACTCCTAAA TACAGATGTA TATCAACTGT GTTCAACTCC 7620 CAAAGTTGAT GAAAGATCAG ATTATGCATC ATCAGGCATA GAAGATATTG TACTTGATAT 7680

TGTCAATTAT GATGGTTCAA TCTCAACAAC AAGATTTAAG AATAATAACA TAAGCTTTGA 7740

TCAACCATAT GCTGCACTAT ACCCATCTGT TGGACCAGGG ATATACTACA AAGGCAAAAT 7800

AATATTTCTC GGGTATGGAG GTCTTGAACA TCCAATAAAT GAGAATGTAA TCTGCAACAC 7860

AACTGGGTGC CCCGGGAAAA CACAGAGAGA CTGTAATCAA GCGTCTCATA GTCCATGGTT 7920

TTCAGATAGG AGGATGGTCA ACTCCATCAT TGTTGCTGAC AAAGGCTTAA ACTCAATTCC 7980

AAAATTGAAA GTATGGACGA TATCTATGCG ACAAAATTAC TGGGGGTCAG AAGGAAGGTT 8040

ACTTCTACTA GGTAACAAGA TCTATATATA TACAAGATCT ACAAGTTGGC ATAGCAAGTT 8100

ACAATTAGGA ATAATTGATA TTACTGATTA CAGTGATATA AGGATAAAAT GGACATGGCA 8160

TAATGTGCTA TCAAGACCAG GAAACAATGA ATGTCCATGG GGACATTCAT GTCCAGATGG 8220

ATGTATAACA GGAGTATATA CTGATGCATA TCCACTCAAT CCCACAGGGA GCATTGTGTC 8280

ATCTGTCATA TTAGACTCAC AAAAATCGAG AGTGAACCCA GTCATAACTT ACTCAACAGC 8340

AACCGAAAGA GTAAACGAGC TGGCCATCCT AAACAGAACA CTCTCAGCTG GATATACAAC 8400

AACAAGCTGC ATTACACACT ATAACAAAGG ATATTGTTTT CATATAGTAG AAATAAATCA 8460

TAAAAGCTTA AACACATTTC AACCCATGTT GTTCAAAACA GAGATTCCAA AAAGCTGCAG 8520

TTAATCATAA TTAACCATAA TATGCATCAA TCTATCTATA ATACAAGTAT ATGATAAGTA 8580

ATCAGCAATC AGACAATAGA CAAAAGGGAA ATATAAAAAA CTTAGGAGCA AAGCGTGCTC 8640

GGGAAATGGA CACTGAATCT AACAATGGCA CTGTATCTGA CATACTCTAT CCTGAGTGTC 8700

ACCTTAACTC TCCTATCGTT AAAGGTAAAA TAGCACAATT ACACACTATT ATGAGTCTAC 8760

CTCAGCCTTA TGATATGGAT GACGACTCAA TACTAGTTAT CACTAGACAG AAAATAAAAC 8820

TTAATAAATT GGATAAAAGA CAACGATCTA TTAGAAGATT AAAATTAATA TTAACTGAAA 8880

AAGTGAATGA CTTAGGAAAA TACACATTTA TCAGATATCC AGAAATGTCA AAAGAAATGT 8940

TCAAATTATA TATACCTGGT ATTAACAGTA AAGTGACTGA ATTATTACTT AAAGCAGATA 9000

GAACATATAG TCAAATGACT GATGGATTAA GAGATCTATG GATTAATGTG CTATCAAAAT 9060

TAGCCTCAAA AAATGATGGA AGCAATTATG ATCTTAATGA AGAAATTAAT AATATATCGA 9120

AAGTTCACAC AACCTATAAA TCAGATAAAT GGTATAATCC ATTCAAAACA TGGTTTACTA 9180 CTGATGAAAG ATCTGAAGCA CAATTAGGAT ATATCAAGAA TCTTAGTAAA CCTGCAAAAG 12360

CCGCAATAAG AATAGCAATG ATATATACAT GGGCATTTGG TAATGATGAG ATATCTTGGA 12420

TGGAAGCCTC ACAGATAGCA CAAACACGTG CAAATTTTAC ACTAGATAGT CTCAAAATTT 12480

TAACACCGGT AGCTACATCA ACAAATTTAT CACACAGATT AAAGGATACT GCAACTCAGA 12540

TGAAATTCTC CAGTACATCA TTGATCAGAG TCAGCAGATT TATAACAATG TCCAATGATA 12600

ACATGTCTAT CAAAGAAGCT AATGAAACCA AAGATACTAA TCTTATTTAT CAAGAAATAA 12660

TGTTAACAGG ATTAAGTGTT TTCGAATATT TATTTAGATT AAAAGAAACC ACAGGACACA 12720

ACCCTATAGT TATGCATCTG CACATAGAAG ATGAGTGTTG TATTAAAGAA AGTTTTAATG 12780

ATGAACATAT TAATCCAGAG TCTACATTAG AATTAATTCG ATATCCTGAA AGTAATGAAT 12840

TTATTTATGA TAAAGACCCA CTCAAAGATG TGGACTTATC AAAACTTATG GTTATTAAAG 12900

ACCATTCTTA CACAATTGAT ATGAATTATT GGGATGATAC TGACATCATA CATGCAATTT 12960

CAATATGTAC TGCAATTACA ATAGCAGATA CTATGTCACA ATTAGATCGA GATAATTTAA 13020

AAGAGATAAT AGTTATTGCA AATGATGATG ATATTAATAG CTTAATCACT GAATTTTTGA 13080

CTCTTGACAT ACTTGTATTT CTCAAGACAT TTGGTGGATT ATTAGTAAAT CAATTTGCAT 13140

ACACTCTTTA TAGTCTAAAA ATAGAAGGTA GGGATCTCAT TTGGGATTAT ATAATGAGAA 13200

CACTGAGAGA TACTTCCCAT TCAATATTAA AAGTATTATC TAATGCATTA TCTCATCCTA 13260

AAGTATTCAA GAGGTTCTGG GATTGTGGAG TTTTAAACCC TATTTATGGT CCTAATATTG 13320

CTAGTCAAGA CCAGATAAAA CTTGCCCTAT CTATATGTGA ATATTCACTA GATCTATTTA 13380

TGAGAGAATG GTTGAATGGT GTATCACTTG AAATATACAT TTGTGACAGC GATATGGAAG 13440

TTGCAAATGA TAGGAAACAA GCCTTTATTT CTAGACACCT TTCATTTGTT TGTTGTTTAG 13500

CAGAAATTGC ATCTTTCGGA CCTAACCTGT TAAACTTAAC ATACTTGGAG AGACTTGATC 13560

TATTGAAACA ATATCTTGAA TTAAATATTA AAGAAGACCC TACTCTTAAA TATGTACAAA 13620

TATCTGGATT ATTAATTAAA TCGTTCCCAT CAACTGTAAC ATACGTAAGA AAGACTGCAA 13680

TCAAATATCT AAGGATTCGC GGTATTAGTC CACCTGAGGT AATTGATGAT TGGGATCCGG 13740

TAGAAGATGA AAATATGCTG GATAACATTG TCAAAACTAT AAATGATAAC TGTAATAAAG 13800

ATAATAAAGG GAATAAAATT AACAATTTCT GGGGACTAGC ACTTAAGAAC TATCAAGTCC 13860 TTAAAATCAG ATCTATAACA AGTGATTCTG ATGATAATGA TAGACTAGAT GCTAATACAA 13920

GTGGTTTGAC ACTTCCTCAA GGAGGGAATT ATCTATCGCA TCAATTGAGA TTATTCGGAA 13980

TCAACAGCAC TAGTTGTCTG AAAGCTCTTG AGTTATCACA AATTTTAATG AAGGAAGTCA 14040

ATAAAGACAA GGACAGGCTC TTCCTGGGAG AAGGAGCAGG AGCTATGCTA GCATGTTATG 14100

ATGCCACATT AGGACCTGCA GTTAATTATT ATAATTCAGG TTTGAATATA ACAGATGTAA 14160

TTGGTCAACG AGAATTGAAA ATATTTCCTT CAGAGGTATC ATTAGTAGGT AAAAAATTAG 14220

GAAATGTGAC ACAGATTCTT AACAGGGTAA AAGTACTGTT CAATGGGAAT CCTAATTCAA 14280

CATGGATAGG AAATATGGAA TGTGAGAGCT TAATATGGAG TGAATTAAAT GATAAGTCCA 14340

TTGGATTAGT ACATTGTGAT ATGGAAGGAG CTATCGGTAA ATCAGAAGAA ACTGTTCTAC 14400

ATGAACATTA TAGTGTTATA AGAATTACAT ACTTGATTGG GGATGATGAT GTTGTTTTAG 14460

TTTCCAAAAT TATACCTACA ATCACTCCGA ATTGGTCTAG AATACTTTAT CTATATAAAT 14520

TATATTGGAA AGATGTAAGT ATAATATCAC TCAAAACTTC TAATCCTGCA TCAACAGAAT 14580

TATATCTAAT TTCGAAAGAT GCATATTGTA CTATAATGGA ACCTAGTGAA ATTGTTTTAT 14640

CAAAACTTAA AAGATTGTCA CTCTTGGAAG AAAATAATCT ATTAAAATGG ATCATTTTAT 14700

CAAAGAAGAG GAATAATGAA TGGTTACATC ATGAAATCAA AGAAGGAGAA AGAGATTATG 14760

GAATCATGAG ACCATATCAT ATGGCACTAC AAATCTTTGG ATTTCAAATC AATTTAAATC 14820

ATCTGGCGAA AGAATTTTTA TCAACCCCAG ATCTGACTAA TATCAACAAT ATAATCCAAA 14880

GTTTTCAGCG AACAATAAAG GATGTTTTAT TTGAATGGAT TAATATAACT CATGATGATA 14940

AGAGACATAA ATTAGGCGGA AGATATAACA TATTCCCACT GAAAAATAAG GGAAAGTTAA 15000

GACTGCTATC GAGAAGACTA GTATTAAGTT GGATTTCATT ATCATTATCG ACTCGATTAC 15060

TTACAGGTCG CTTTCCTGAT GAAAAATTTG AACATAGAGC ACAGACTGGA TATGTATCAT 15120

TAGCTGATAC TGATTTAGAA TCATTAAAGT TATTGTCGAA AAACATCATT AAGAATTACA 15180

GAGAGTGTAT AGGATCAATA TCATATTGGT TTCTAACCAA AGAAGTTAAA ATACTTATGA 15240

AATTGATTGG TGGTGCTAAA TTATTAGGAA TTCCCAGACA ATATAAAGAA CCCGAAGACC 15300

AGTTATTAGA AAACTACAAT CAACATGATG AATTTGATAT CGATTAAAAC ATAAATACAA 15360

TGAAGATATA TCCTAACCTT TATCTTTAAG CCTAGGAATA GACAAAAAGT AAGAAAAACA 15420 TGTAATATAT ATATACCAAA CAGAGTTCTT CTCTTGTTTG GT 15462 (2) INFORMATION FOR SEQ ID NO: 20:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2233 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 20:

Met Asp Thr Glu Ser Asn Asn Gly Thr Val Ser Asp He Leu Tyr Pro 1 5 10 15

Glu Cys Hiβ Leu Aβn Ser Pro He Val Lys Gly Lys He Ala Gin Leu 20 25 30

His Thr He Met Ser Leu Pro Gin Pro Tyr Asp Met Asp Asp Asp Ser 35 40 45

He Leu Val He Thr Arg G n Lys He Lys Leu Asn Lys Leu Asp Lys 50 55 60

Arg Gin Arg Ser He Arg Arg Leu Lys Leu He Leu Thr Glu Lye Val 65 70 75 80

Aen Aβp Leu Gly Lye Tyr Thr Phe He Arg Tyr Pro Glu Met Ser Lye 85 90 95

Glu Met Phe Lye Leu Tyr He Pro Gly He Aen Ser Lye Val Thr Glu 100 105 110

Leu Leu Leu Lye Ala Asp Arg Thr Tyr Ser Gin Met Thr Asp Gly Leu 115 120 125

Arg Asp Leu Trp He λβn Val Leu Ser Lye Leu Ala Ser Lye Asn Aβp 130 135 140

Gly Ser Aβn Tyr Aβp Leu Aβn Glu Glu He Aβn Aβn He Ser Lys Val 145 150 155 160

Hiβ Thr Thr Tyr Lys Ser Asp Lye Trp Tyr Aβn Pro Phe Lye Thr Trp 165 170 175

Phe Thr He Lys Tyr Aβp Met Arg Arg Leu Gin Lye Ala Arg Aen Glu 180 185 190

He Thr Phe Asn Val Gly Lys Asp Tyr Asn Leu Leu Glu Asp Gin Lys 195 200 205

Asn Phe Leu Leu He His Pro Glu Leu Val Leu He Leu Aβp Lye Gin 210 215 220

Aen Tyr Asn Gly Tyr Leu He Thr Pro Glu Leu Val Leu Met Tyr Cys 225 230 235 240

Asp Val Val Glu Gly Arg Trp Asn He Ser Ala Cyβ Ala Lys Leu Asp 245 250 255

Pro Lys Leu Gin Ser Met Tyr Gin Lys Gly Asn Aen Leu Trp Glu Val 260 265 270

He Aβp Lye Leu Phe Pro He Met Gly Glu Lye Thr Phe Asp Val He 275 280 285

Ser Leu Leu Glu Pro Leu Ala Leu Ser Leu He Gin Thr Hiβ Asp Pro 290 295 300

Val Lys Gin Leu Arg Gly Ala Phe Leu Asn His Val Leu Ser Glu Met 305 310 315 320

Glu Leu He Phe Glu Ser Arg Glu Ser He Lys Glu Phe Leu Ser Val 325 330 335

Asp Tyr He Asp Lys He Leu Asp He Phe Asn Lys Ser Thr He Asp 340 345 350

Glu He Ala Glu He Phe Ser Phe Phe Arg Thr Phe Gly Hiβ Pro Pro 355 360 365

Leu Glu Ala Ser He Ala Ala Glu Lye Val Arg Lys Tyr Met Tyr He 370 375 380

Gly Lys Gin Leu Lys Phe Asp Thr He Aβn Lye Cys His Ala He Phe 385 390 395 400

Cys Thr He He He Asn Gly Tyr Arg Glu Arg His Gly Gly Gin Trp 405 410 415

Pro Pro Val Thr Leu Pro Aβp Hiβ Ala Hiβ Glu Phe He He Aβn Ala 420 425 430

Tyr Gly Ser Aβn Ser Ala He Ser Tyr Glu Asn Ala Val Asp Tyr Tyr 435 440 445

Gin Ser Phe He Gly He Lys Phe Asn Lys Phe He Glu Pro Gin Leu 450 455 460 Asp Glu Aβp Leu Thr He Tyr Met Lye Aβp Lys Ala Leu Ser Pro Lys 465 470 475 480

Lys Ser Asn Trp Asp Thr Val Tyr Pro Ala Ser Asn Leu Leu Tyr Arg 485 490 495

Thr Asn Ala Ser Aβn Glu Ser Arg Arg Leu Val Glu Val Phe He Ala 500 505 510

Asp Ser Lys Phe Asp Pro His Gin He Leu Asp Tyr Val Glu Ser Gly 515 520 525

Asp Trp Leu Asp Aβp Pro Glu Phe Aβn He Ser Tyr Ser Leu Lye Glu 530 535 540

Lye Glu He Lye Gin Glu Gly Arg Leu Phe Ala Lye Met Thr Tyr Lys 545 550 555 560

Met Arg Ala Thr Gin Val Leu Ser Glu Thr Leu Leu Ala Asn Asn He 565 570 575

Gly Lys Phe Phe Gin Glu Aen Gly Met Val Lye Gly Glu He Glu Leu 580 585 590

Leu Lys Arg Leu Thr Thr He Ser He Ser Gly Val Pro Arg Tyr Aβn 595 600 605

Glu Val Tyr Asn Aβn Ser Lye Ser His Thr Asp Asp Leu Lys Thr Tyr 610 615 620

Aβn Lys He Ser Asn Leu Asn Leu Ser Ser Asn Gin Lys Ser Lys Lys 625 630 635 640

Phe Glu Phe Lys Ser Thr Asp He Tyr Asn Asp Gly Tyr Glu Thr Val 645 650 655

Ser Cys Phe Leu Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Ser Thr Ala Leu Phe Gly Glu Thr Cys Asn Gin He Phe Gly 675 680 685

Leu Asn Lys Leu Phe Asn Trp Leu His Pro Arg Leu Glu Gly Ser Thr 690 695 700

He Tyr Val Gly Asp Pro Tyr Cys Pro Pro Ser Asp Lys Glu His He 705 710 715 720

Ser Leu Glu Asp His Pro Aβp Ser Gly Phe Tyr Val Hiβ Aen Pro Arg 725 730 735 Gly Gly He Glu Gly Phe Cys Gin Lys Leu Trp Thr Leu He Ser He 740 745 750

Ser Ala He His Leu Ala Ala Val Arg He Gly Val Arg Val Thr Ala 755 760 765

Met Val Gin Gly Aβp Aβn Gin Ala He Ala Val Thr Thr Arg Val Pro 770 775 780

Aβn Aβn Tyr Asp Tyr Arg Val Lys Lys Glu He Val Tyr Lys Asp Val 785 790 795 800

Val Arg Phe Phe Asp Ser Leu Arg Glu Val Met Asp Asp Leu Gly Hiβ 805 810 815

Glu Leu Lys Leu Asn Glu Thr He He Ser Ser Lye Met Phe He Tyr 820 825 830

Ser Lye Arg He Tyr Tyr Aβp Gly Arg He Leu Pro Gin Ala Leu Lys 835 840 845

Ala Leu Ser Arg Cyβ Val Phe Trp Ser Glu Thr Val He Asp Glu Thr 850 855 860

Arg Ser Ala Ser Ser Aβn Leu Ala Thr Ser Phe Ala Lye Ala He Glu 865 870 875 880

Asn Gly Tyr Ser Pro Val Leu Gly Tyr Ala Cys Ser He Phe Lys Aβn 885 890 895

He Gin Gin Leu Tyr He Ala Leu Gly Met Aβn He Aβn Pro Thr He 900 905 910

Thr Gin Aβn He Arg Aβp Gin Tyr Phe Arg Aβn Pro Aβn Trp Met Gin 915 920 925

Tyr Ala Ser Leu He Pro Ala Ser Val Gly Gly Phe Asn His Met Ala 930 935 940

Met Ser Arg Cys Phe Val Arg Asn He Gly Asp Pro Ser Val Ala Ala 945 950 955 960

Leu Ala Aβp He Lye Arg Phe He Lys Ala Asn Leu Leu Asp Arg Ser 965 970 975

Val Leu Tyr Arg He Met Aen Gin Glu Pro Gly Glu Ser Ser Phe Phe 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Cys Aen Leu Pro Gin Ser Gin Aβn 995 1000 1005

He Thr Thr Met He Lys Aβn He Thr Ala Arg Asn Val Leu Gin Asp 1010 1015 1020

Ser Pro Aβn Pro Leu Leu Ser Gly Leu Phe Thr Aβn Thr Met He Glu 1025 1030 1035 1040

Glu Aβp Glu Glu Leu Ala Glu Phe Leu Met Asp Arg Lys Val He Leu 1045 1050 1055

Pro Arg Val Ala His Asp He Leu Asp Asn Ser Leu Thr Gly He Arg 1060 1065 1070

Asn Ala He Ala Gly Met Leu Asp Thr Thr Lys Ser Leu He Arg Val 1075 1080 1085

Gly He Aβn Arg Gly Gly Leu Thr Tyr Ser Leu Leu Arg Lys He Ser 1090 1095 1100

Asn Tyr Asp Leu Val Gin Tyr Glu Thr Leu Ser Arg Thr Leu Arg Leu 1105 1110 1115 1120

He Val Ser Asp Lys He Lys Tyr Glu Asp Met Cys Ser Val Asp Leu 1125 1130 1135

Ala He Ala Leu Arg Gin Lys Met Trp He His Leu Ser Gly Gly Arg 1140 1145 1150

Met He Ser Gly Leu Glu Thr Pro Asp Pro Leu Glu Leu Leu Ser Gly 1155 1160 1165

Val Val He Thr Gly Ser Glu His Cyβ Lye He Cys Tyr Ser Ser Asp 1170 1175 1180

Gly Thr Asn Pro Tyr Thr Trp Met Tyr Leu Pro Gly Asn He Lys He 1185 1190 1195 1200

Gly Ser Ala Glu Thr Gly He Ser Ser Leu Arg Val Pro Tyr Phe Gly 1205 1210 1215

Ser Val Thr Aβp Glu Arg Ser Glu Ala Gin Leu Gly Tyr He Lye Asn 1220 1225 1230

Leu Ser Lys Pro Ala Lys Ala Ala He Arg He Ala Met He Tyr Thr 1235 1240 1245

Trp Ala Phe Gly Asn Asp Glu He Ser Trp Met Glu Ala Ser Gin He 1250 1255 1260

Ala Gin Thr Arg Ala Aβn Phe Thr Leu Aβp Ser Leu Lye He Leu Thr 1265 1270 1275 1280

Pro Val Ala Thr Ser Thr Asn Leu Ser His Arg Leu Lys Asp Thr Ala 1285 1290 1295 Thr Gin Met Lys Phe Ser Ser Thr Ser Leu He Arg Val Ser Arg Phe 1300 1305 1310

He Thr Met Ser Asn Aβp Aβn Met Ser He Lye Glu Ala Asn Glu Thr 1315 1320 1325

Lys Asp Thr Asn Leu He Tyr Gin Gin He Met Leu Thr Gly Leu Ser 1330 1335 1340

Val Phe Glu Tyr Leu Phe Arg Leu Lys Glu Thr Thr Gly His Asn Pro 1345 1350 1355 1360

He Val Met His Leu His He Glu Asp Glu Cys Cys He Lys Glu Ser 1365 1370 1375

Phe Asn Aβp Glu Hiβ He Aβn Pro Glu Ser Thr Leu Glu Leu He Arg 1380 1385 1390

Tyr Pro Glu Ser Asn Glu Phe He Tyr Asp Lys Aβp Pro Leu Lys Aβp 1395 1400 1405

Val Aep Leu Ser Lye Leu Met Val He Lye Aβp Hiβ Ser Tyr Thr He 1410 1415 1420

Aep Met Aβn Tyr Trp Aβp Aβp Thr Aβp He He Hiβ Ala He Ser He 1425 1430 1435 1440

Cyβ Thr Ala He Thr He Ala Asp Thr Met Ser Gin Leu Asp Arg Asp 1445 1450 1455

Asn Leu Lys Glu He He Val He Ala Asn Asp Asp Aβp He Aβn Ser 1460 1465 1470

Leu He Thr Glu Phe Leu Thr Leu Aβp He Leu Val Phe Leu Lye Thr 1475 1480 1485

Phe Gly Gly Leu Leu Val Aen Gin Phe Ala Tyr Thr Leu Tyr Ser Leu 1490 1495 1500

Lye He Glu Gly Arg Asp Leu He Trp Asp Tyr He Met Arg Thr Leu 1505 1510 1515 1520

Arg Asp Thr Ser His Ser He Leu Lys Val Leu Ser Asn Ala Leu Ser 1525 1530 1535

His Pro Lys Val Phe Lys Arg Phe Trp Asp Cys Gly Val Leu Asn Pro 1540 1545 1550

He Tyr Gly Pro Aβn He Ala Ser Gin Asp Gin He Lys Leu Ala Leu 1555 1560 1565 Ser He Cys Glu Tyr Ser Leu Asp Leu Phe Met Arg Glu Trp Leu Asn 1570 1575 1580

Gly Val Ser Leu Glu He Tyr He Cys Aβp Ser Aβp Met Glu Val Ala 1585 1590 1595 1600

Aβn Asp Arg Lys Gin Ala Phe He Ser Arg His Leu Ser Phe Val Cyβ 1605 1610 1615

Cyβ Leu Ala Glu He Ala Ser Phe Gly Pro Aβn Leu Leu Aβn Leu Thr 1620 1625 1630

Tyr Leu Glu Arg Leu Aβp Leu Leu Lye Gin Tyr Leu Glu Leu Aβn He 1635 1640 1645

Lye Glu Aep Pro Thr Leu Lye Tyr Val Gin He Ser Gly Leu Leu He 1650 1655 1660

Lye Ser Phe Pro Ser Thr Val Thr Tyr Val Arg Lye Thr Ala He Lys 1665 1670 1675 1680

Tyr Leu Arg He Arg Gly He Ser Pro Pro Glu Val He Asp Aβp Trp 1685 1690 1695

Aβp Pro Val Glu Aβp Glu Asn Met Leu Asp Asn He Val Lys Thr He 1700 1705 1710

Asn Asp Asn Cys Aβn Lye Aβp Aβn Lye Gly Asn Lys He Asn Aen Phe 1715 1720 1725

Trp Gly Leu Ala Leu Lye Aen Tyr Gin Val Leu Lye He Arg Ser He 1730 1735 1740

Thr Ser Aep Ser Aβp Aβp Aβn Aβp Arg Leu Aβp Ala Aβn Thr Ser Gly 1745 1750 1755 1760

Leu Thr Leu Pro Gin Gly Gly Aβn Tyr Leu Ser Hiβ Gin Leu Arg Leu 1765 1770 1775

Phe Gly He Aen Ser Thr Ser Cye Leu Lye Ala Leu Glu Leu Ser Gin 1780 1785 1790

He Leu Met Lye Glu Val Aβn Lys Aβp Lye Aep Arg Leu Phe Leu Gly 1795 1800 1805

Glu Gly Ala Gly Ala Met Leu Ala Cyβ Tyr Asp Ala Thr Leu Gly Pro 1810 1815 1820

Ala Val Asn Tyr Tyr Asn Ser Gly Leu Asn He Thr Asp Val He Gly 1825 1830 1835 1840

Gin Arg Glu Leu Lys He Phe Pro Ser Glu Val Ser Leu Val Gly Lys 1845 1850 1855

Lys Leu Gly Asn Val Thr Gin He Leu Asn Arg Val Lys Val Leu Phe 1860 1865 1870

Asn Gly Asn Pro Asn Ser Thr Trp He Gly Aβn Met Glu Cys Glu Ser 1875 1880 1885

Leu He Trp Ser Glu Leu Asn Asp Lys Ser He Gly Leu Val His Cys 1890 1895 1900

Aβp Met Glu Gly Ala He Gly Lye Ser Glu Glu Thr Val Leu Hiβ Glu 1905 1910 1915 1920

His Tyr Ser Val He Arg He Thr Tyr Leu He Gly Asp Asp Asp Val 1925 1930 1935

Val Leu Val Ser Lys He He Pro Thr He Thr Pro Asn Trp Ser Arg 1940 1945 1950

He Leu Tyr Leu Tyr Lys Leu Tyr Trp Lye Asp Val Ser He He Ser 1955 1960 1965

Leu Lys Thr Ser Asn Pro Ala Ser Thr Glu Leu Tyr Leu He Ser Lys 1970 1975 1980

Asp Ala Tyr Cys Thr He Met Glu Pro Ser Glu He Val Leu Ser Lys 1985 1990 1995 2000

Leu Lys Arg Leu Ser Leu Leu Glu Glu Asn Aβn Leu Leu Lys Trp He 2005 2010 2015

He Leu Ser Lye Lye Arg Aβn Asn Glu Trp Leu His Hiβ Glu He Lys 2020 2025 2030

Glu Gly Glu Arg Asp Tyr Gly He Met Arg Pro Tyr His Met Ala Leu 2035 2040 2045

Gin He Phe Gly Phe Gin He Asn Leu Asn His Leu Ala Lys Glu Phe 2050 2055 2060

Leu Ser Thr Pro Asp Leu Thr Asn He Asn Asn He He Gin Ser Phe 2065 2070 2075 2080

Gin Arg Thr He Lys Asp Val Leu Phe Glu Trp He Asn He Thr His 2085 2090 2095

Asp Asp Lys Arg His Lys Leu Gly Gly Arg Tyr Asn He Phe Pro Leu 2100 2105 2110

Lys Asn Lys Gly Lys Leu Arg Leu Leu Ser Arg Arg Leu Val Leu Ser 2115 2120 2125 Trp He Ser Leu Ser Leu Ser Thr Arg Leu Leu Thr Gly Arg Phe Pro 2130 2135 2140

Aβp Glu Lye Phe Glu Hiβ Arg Ala Gin Thr Gly Tyr Val Ser Leu Ala 2145 2150 2155 2160

Asp Thr Aβp Leu Glu Ser Leu Lys Leu Leu Ser Lys Asn He He Lys 2165 2170 2175

Asn Tyr Arg Glu Cys He Gly Ser He Ser Tyr Trp Phe Leu Thr Lys 2180 2185 2190

Glu Val Lys He Leu Met Lye Leu He Gly Gly Ala Lys Leu Leu Gly 2195 2200 2205

He Pro Arg Gin Tyr Lys Glu Pro Glu Asp Gin Leu Leu Glu Asn Tyr 2210 2215 2220

Asn Gin His Aβp Glu Phe Aβp He Aβp 2225 2230

(2) INFORMATION FOR SEQ ID NO: 21:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15462 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID Nθ:21:

ACCAAACAAG AGAAGAAACT TGCTTGGTAA TATAAATTTA ACTTAAAATT AACTTAGGAT 60

TTAAGACATT GACTAGAAGG TCAAGAAAAG GGAACTCTAT AATTTCAAAA ATGTTGAGCC 120

TATTTGATAC ATTTAATGCA CGTAGGCAAG AAAACATAAC AAAATCAGCC GGTGGAGCTA 180

TCATTCCTGG ACAGAAAAAT ACTGTCTCTA TATTCGCCCT TGGACCGACA ATAACTGATG 240

ATAATGAGAA AATGACATTA GCTCTTCTAT TTCTATCTCA TTCACTAGAT AATGAGAAAC 300

AACATGCACA AAGGGCAGGG TTCTTGGTGT CTTTATTGTC AATGGCTTAT GCCAATCCAG 360

AGCTCTACCT AACAACAAAT GGAAGTAATG CAGATGCCAA GTATGTCATA TACATGATTG 420

AGAAAGATCT AAAACGGCAA AAGTATGGAG GATTTGTGGT TAAGACGAGA GAGATGATAT 480 ATGAAAAGAC AACTGATTGG ATATTTGGAA GTGACCTGGA TTATGATCAG GAAACTATGT 540

TGCAGAACGG CAGGAACAAT TCAACAATTG AAGACCTTGT CCACACATTT GGGTATCCAT 600

CATGTTTAGG AGCTCTTATA ATACAGATCT GGATAGTTCT GGTCAAAGCT ATCACTAGTA 660

TCTCAGGGTT AAGAAAAGGC TTTTTCACCC GATTGGAAGC TTTCAGACAA GATGGAACAG 720

TGCAGGCAGG GCTGGTATTG AGCGGTGACA CAGTGGATCA GATTGGGTCA ATCATGCGGT 780

CTCAACAGAG CTTGGTAACT CTTATGGTTG AAACATTAAT AACAATGAAT ACCAGCAGAA 840

ATGACCTCAC AACCATAGAA AAGAATATAC AAATTGTTGG CAACTACATA AGAGATGCAG 900

GTCTCGCTTC ATTCTTCAAT ACAATCAGAT ATGGAATTGA GACCAGAATG GCAGCTTTGA 960

CTCTATCCAC TCTCAGACCA GATATCAATA GATTAAAAGC TTTGATGGAA CTGTATTTAT 1020

CAAAGGGACC ACGCGCTCCT TTCATCTGTA TCCTCAGAGA TCCTATACAT GGTGAGTTCG 1080

CACCAGGCAA CTATCCTGCC ATATGGAGCT ATGCAATGGG GGTGGCAGTT GTACAAAATA 1140

GAGCCATGCA ACAGTATGTG ACGGGAAGAT CATATCTAGA CATTGATATG TTCCAGCTAG 1200

GACAAGCAGT AGCACGTGAT GCCGAAGCTC AAATGAGCTC AACACTGGAA GATGAACTTG 1260

GAGTGACACA CGAAGCTAAA GAAAGCTTGA AGAGACATAT AAGGAACATA AACAGTTCAG 1320

AGACATCTTT CCACAAACCG ACAGGTGGAT CAGCCATAGA GATGGCAATA GATGAAGAGC 1380

CAGAACAATT CGAACATAGA GCAGATCAAG AACAAAATGG AGAACCTCAA TCATCGATAA 1440

TTCAATATGC CTGGGCAGAA GGAAATAGAA GCGATGATCA GACTGAGCAA GCTACAGAAT 1500

CTGACAATAT CAAGACCGAA CAACAAAACA TCAGAGACAG ACTAAACAAG AGACTCAACG 1560

ACAAGAAGAA ACAAAGCAGT CAACCACCCA CTAATCCCAC AAACAGAACA AACCAGGACG 1620

AAATAGATGA TCTGTTTAAC GCATTTGGAA GCAACTAATC GAATCAACAT TTTAATCTAA 1680

ATCAATAATA AATAAGAAAA ACTTAGGATT AAAGAATCCT ATCATACCGG AATATAGGGT 1740

GGTAAATTTA GAGTCTGCTT GAAACTCAAT CAATAGAGAG TTGATGGAAA GCGATGCTAA 1800

AAACTATCAA ATCATGGATT CTTGGGAAGA GGAATCAAGA GATAAATCAA CTAATATCTC 1860

CTCGGCCCTC AACATCATTG AATTCATACT CAGCACCGAC CCCCAAGAAG ACTTATCGGA 1920

AAACGACACA ATCAAGAGAA GAACCCAGCA ACTCAGTGCC ACCATCTGTC AACCAGAAAT 1980

CAAACCAACA GAAACAAGTG AGAAAGATAG TGGATCAACT GACAAAAATA GAGAGTCTGG 2040 GTCATCACAC GAATGTACAA CAGAAGCAAA AGATAGAAAC ATTGATCAGG AAACTGTACA 2100

GAGAGGACCT GGGAGAAGAA GCAGCTCAGA TAGTAGAGCT GAGACTGTGG TCTCTGGAGG 2160

AATCCCCAGA AGCATCACAG ATTCTAAAAA TGGAACCCAA AACACGGAGG ATATTGATCT 2220

CAATGAAATT AGAAAGATGG ATAAGGACTC TATTGAGGGG AAAATGCGAC AATCTGCAAA 2280

TGTTCCAAGC GAGATATCAG GAAGTGATGA CATATTTACA ACAGAACAAA GTAGAAACAG 2340

TGATCATGGA AGAAGCCTGG AATCTATCAG TACACCTGAT ACAAGATCAA TAAGTGTTGT 2400

TACTGCTGCA ACACCAGATG ATGAAGAAGA AATACTAATG AAAAATAGTA GGACAAAGAA 2460

AAGTTCTTCA ACACATCAAG AAGATGACAA AAGAATTAAA AAAGGGGGAA AAGGGAAAGA 2520

CTGGTTTAAG AAATCAAAAG ATACCGACAA CCAGATACCA ACATGAGACT ACAGATCCAC 2580

ATCAAAAGGG CAGAAGAAAA TCTCAAAGAC AACAACCACC AACACCGACA CAAAGGGGCA 2640

AACAGAAATA CAGACAGAAT GATCAGAAAC ACAATCCTCA TCATGGAATC TCATCATCGA 2700

CAACAACACC GACCGGAACG AACAGACAAG CACAACTCCT CCAACAACAA CTTCGAGATC 2760

AACTTATACA AAAGAATCGA TCCGAACAAA CTCTGAATCC AAACCCAAGA CACAAAAGAC 2820

AAATGGAAAG GAAAGGAAGG ATACAGAAGA GAGCAATCGA TTTACAGAGA GGGCAATTAC 2880

TCTATTGCAG AATCTTGGTG TAATTCAATC CACATCAAAA CTAGATTTAT ATCAAGAGAA 2940

ACGAGTTGTA TGTGTAGCAA ATGTACTAAA CAATGTAGAT ACTGCATCAA AGATAGATTT 3000

CCTGGCAGGA TTAGTCATAG GGGTTTCAAT GGACAACGAC ACAAAATTAA CACAGATACA 3060

AAATGAAATG CTAAACCTCA AAGCAGATCT AAAGAAAATG GACGAATCAC ATAGAAGATT 3120

GATAGAAAAT CAAAGAGAAC AACTGTCATT GATCACGTCA CTAATTTCAA ATCTCAAAAT 3180

TATGACTGAG AGAGGAGGAA AGAAAGACCA AAATGAATCC AATGAGAGAG TATCGATGAT 3240

CAAAACAAAA TTGAAAGAAG AAAAGATCAA GAAGACGAGG TTTGACCCAC TTATGGAGGC 3300

ACAAGGCATT GACAAGAATA TACCCGATCT ATATCGACAT GCAGGAGATA CACTAGAGAA 3360

CGATGTACAA GTTAAATCAG AGATATTAAG TTCATACAAT GAGTCAAATG CAACAAGACT 3420

AATACCCAAA AAAGTGAGCA GTACAATGAG ATCACTAGTT GCAGTCATCA ACAACAGCAA 3480

TCTCTCACAA AGCACAAAAC AATCATACAT AAACGAACTC AAACGTTGCA AAAATGATGA 3540

AGAAGTATCT GAATTAATGG ACATGTTCAA TGAAGATGTC AACAATTGCC AATGATCCAA 3600 CAAAGAAACG ACACCGAACA AACAGACAAG AAACAACAGT AGATCAAAAC CTGTCAACAC 3660

ACACAAAATC AAGCAGAATG AAACAACAGA TATCAATCAA TATACAAATA AGAAAAACTT 3720

AGGATTAAAG AATAAATTAA TCCTTGTCCA AAATGAGTAT AACTAACTCT GCAATATACA 3780

CATTCCCAGA ATCATCATTC TCTGAAAATG GTCATATAGA ACCATTACCA CTCAAAGTCA 3840

ATGAACAGAG GAAAGCAGTA CCCCACATTA GAGTTGCCAA GATCGGAAAT CCACCAAAAC 3900

ACGGATCCCG GTATTTAGAT GTCTTCTTAC TCGGCTTCTT CGAGATGGAA CGAATCAAAG 3960

ACAAATACGG GAGTGTGAAT GATCTCGACA GTGACCCGAG TTACAAAGTT TGTGGCTCTG 4020

GATCATTACC AATCGGATTG GCTAAGTACA CTGGGAATGA CCAGGAATTG TTACAAGCCG 4080

CAACCAAACT GGATATAGAA GTGAGAAGAA CAGTCAAAGC GAAAGAGATG GTTGTTTACA 4140

CGGTACAAAA TATAAAACCA GAACTGTACC CATGGTCCAA TAGACTAAGA AAAGGAATGC 4200

TGTTCGATGC CAACAAAGTT GCTCTTGCTC CTCAATGTCT TCCACTAGAT AGGAGCATAA 4260

AATTTAGAGT AATCTTCGTG AATTGTACGG CAATTGGATC AATAACCTTG TTCAAAATTC 4320

CTAAGTCAAT GGCATCACTA TCTCTAACCA ACACAATATC AATCAATCTG CAGGTACACA 4380

TAAAAACAGG GGTTCAGACT GATTCTAAAG GGATAGTTCA AATTTTGGAT GAGAAAGGCG 4440

AAAAATCACT GAATTTCATG GTCCATCTCG GATTGATCAA AAGAAAAGTA GGCAGAATGT 4500

ACTCTGTTGA ATACTGTAAA CAGAAAATCG AGAAAATGAG ATTGATATTT TCTTTAGGAC 4560

TAGTTGGAGG AATCAGTCTT CATGTCAATG CAACTGGGTC CATATCAAAA ACACTAGCAA 4620

GTCAGCTGGT ATTCAAAAGA GAGATTTGTT ATCCTTTAAT GGATCTAAAT CCGCATCTCA 4680

ATCTAGTTAT CTGGGCTTCA TCAGTAGAGA TTACAAGAGT GGATGCAATT TTCCAACCTT 4740

CTTTACCTGG CGAGTTCAGA TACTATCCTA ATATTATTGC AAAAGGAGTT GGGAAAATCA 4800

AACAATGGAA CTAGTAATCT CTATTTTAGT CCGGACG AT CTATTAAGCC GAAGCAAATA 4860

AAGGATAATC AAAAACTTAG GACAAAAGAG GTCAATACCA ACAACTATTA GCAGTCACAC 4920

TCGCAAGAAT AAGAGAGAAG GGACCAAAAA AGTCAAATAG GAGAAATCAA AACAAAAGGT 4980

ACAGAACACC AGAACAACAA AATCAAAACA TCCAACTCAC TCAAAACAAA AATTCCAAAA 5040

GAGACCGGCA ACACAACAAG CACTGAACAC AATGCCAACT TCAATACTGC TAATTATTAC 5100

AACCATGATC ATGGCATCTT TCTGCCAAAT AGATATCACA AAACTACAGC ACGTAGGTGT 5160 ATTGGTCAAC AGTCCCAAAG GGATGAAGAT ATCACAAAAC TTTGAAACAA GATATCTAAT 5220

TTTGAGCCTC ATACCAAAAA TAGAAGACTC TAACTCTTGT GGTGACCAAC AGATCAAGCA 5280

ATACAAGAAG TTATTGGATA GACTGATCAT CCCTTTATAT GATGGATTAA GATTACAGAA 5340

AGATGTGATA GTAACCAATC AAGAATCCAA TGAAAACACT GATCCCAGAA CAAAACGATT 5400

CTTTGGAGGG GTAATTGGAA CCATTGCTCT GGGAGTAGCA ACCTCAGCAC AAATTACAGC 5460

GGCAGTTGCT CTGGTTGAAG CCAAGCAGGC AAGATCAGAC ATCGAAAAAC TCAAAGAAGC 5520

AATTAGGGAC ACAAATAAAG CAGTGCAGTC AGTTCAGAGC TCCATAGGAA ATTTAATAGT 5580

AGCAATTAAA TCAGTCCAGG ATTATGTTAA CAAAGAAATC GTGCCATCGA TTGCGAGGCT 5640

AGGTTGTGAA GCAGCAGGAC TTCAATTAGG AATTGCATTA ACACAGCATT ACTCAGAATT 5700

AACAAACATA TTTGGTGATA ACATAGGATC GTTACAAGAA AAAGGAATAA AATTACAAGG 5760

TATAGCATCA TTATACCGCA CAAATATCAC AGAAATATTC ACAACATCAA CAGTTGATAA 5820

ATATGATATC TATGATCTGT TATTTACAGA ATCAATAAAG GTGAGAGTTA TAGATGTTGA 5880

CTTGAATGAT TACTCAATCA CCCTCCAAGT CAGACTCCCT TTATTAACTA GGCTGCTGAA 5940

CACTCAGATC TACAAAGTAG ATTCCATATC ATATAACATC CAAAACAGAG AATGGTATAT 6000

CCCTCTTCCC AGCCATATCA TGACGAAAGG GGCATTTCTA GGTGGAGCAG ACGTCAAAGA 6060

ATGTATAGAA GCATTCAGCA GCTATATATG CCCTTCTGAT CCAGGATTTG TATTAAACCA 6120

TGAAATAGAG AGCTGCTTAT CAGGAAACAT ATCCCAATGT CCAAGAACAA CGGTCACATC 6180

AGACATTGTT CCAAGATATG CATTTGTCAA TGGAGGAGTG GTTGCAAACT GTATAACAAC 6240

CACCTGTACA TGCAACGGAA TTGGTAATAG AATCAATCAA CCACCTGATC AAGGAGTAAA 6300

AATTATAACA CATAAAGAAT GTAGTACAGT AGGTATCAAC GGAATGCTGT TCAATACAAA 6360

TAAAGAAGGA ACTCTTGCAT TCTATACACC AAATGATATA ACACTAAACA ATTCTGTTAC 6420

ACTTGATCCA ATTGACATAT CAATCGAGCT CAACAAGGCC AAATCAGATC TAGAAGAATC 6480

AAAAGAATGG ATAAGAAGGT CAAATCAAAA ACTAGATTCT ATTGGAAATT GGCATCAATC 6540

TAGCACTACA ATCATAATTA TTTTGATAAT GATCATTATA TTGTTTATAA TTAATATAAC 6600

GATAATTACA ATTGCAATTA AGTATTACAG AATTCAAAAG AGAAATCGAG TGGATCAAAA 6660

TGACAAGCCA TATGTACTAA CAAACAAATA ACATATCTAC AGATCATTAG ATATTAAAAT 6720 TATAAAAAAC TTAGGAGTAA AGTTACGCAA TCCAACTCTA CTCATATAAT TGAGGAAGGA 6780

CCCAATAGAC AAATCCAAAT TCGAGATGGA ATACTGGAAG CATACCAATC ACGGAAAGGA 6840

TGCTGGCAAT GAGCTGGAGA CGTCTATGGC TACTCATGGC AACAAGCTCA CTAATAAGAT 6900

AATATACATA TTATGGACAA TAATCCTGGT GTTATTATCA ATAGTCTTCA TCATAGTGCT 6960

AATTAATTCC ATCAAAAGTG AAAAGGCCCA CGAATCATTG CTGCAAGACA TAAATAATGA 7020

GTTTATGGAA ATTACAGAAA AGATCCAAAT GGCATCGGAT AATACCAATG ATCTAATACA 7080

GTCAGGAGTG AATACAAGGC TTCTTACAAT TCAGAGTCAT GTCCAGAATT ACATACCAAT 7140

ATCATTGACA CAACAGATGT CAGATCTTAG GAAATTCATT AGTGAAATTA CAATTAGAAA 7200

TGATAATCAA GAAGTGCTGC CACAAAGAAT AACACATGAT GTAGGTATAA AACCTTTAAA 7260

TCCAGATGAT TTTTGGAGAT GCACGTCTGG TCTTCCATCT TTAATGAAAA CTCCAAAAAT 7320

AAGGTTAATG CCAGGGCCGG GATTATTAGC TATGCCAACG ACTGTTGATG GCTGTGTTAG 7380

AACTCCGTCT TTAGTTATAA ATGATCTGAT TTATGCTTAT ACCTCAAATC TAATTACTCG 7440

AGGTTGTCAG GATATAGGAA AATCATATCA AGTCTTACAG ATAGGGATAA TAACTGTAAA 7500

CTCAGACTTG GTACCTGACT TAAATCCTAG GATCTCTCAT ACCTTTAACA TAAATGACAA 7560

TAGGAAGTCA TGTTCTCTAG CACTCCTAAA TACAGATGTA TATCAACTGT GTTCAACTCC 7620

CAAAGTTGAT GAAAGATCAG ATTATGCATC ATCAGGCATA GAAGATATTG TACTTGATAT 7680

TGTCAATTAT GATGGTTCAA TCTCAACAAC AAGATTTAAG AATAATAACA TAAGCTTTGA 7740

TCAACCATAT GCTGCACTAT ACCCATCTGT TGGACCAGGG ATATACTACA AAGGCAAAAT 7800

AATATTTCTC GGGTATGGAG GTCTTGAACA TCCAATAAAT GAGAATGTAA TCTGCAACAC 7860

AACTGGGTGC CCCGGGAAAA CACAGAGAGA CTGTAATCAA GCGTCTCATA GTCCATGGTT 7920

TTCAGATAGG AGGATGGTCA ACTCCATCAT TGTTGCTGAC AAAGGCTTAA ACTCAATTCC 7980

AAAATTGAAA GTATGGACGA TATCTATGCG ACAAAATTAC TGGGGGTCAG AAGGAAGGTT 8040

ACTTCTACTA GGTAACAAGA TCTATATATA TACAAGATCT ACAAGTTGGC ATAGCAAGTT 8100

AGAATTAGGA ATAATTGATA TTACTGATTA CAGTGATATA AGGATAAAAT GGACATGGCA 8160

TAATGTGCTA TCAAGACCAG GAAACAATGA ATGTCCATGG GGACATTCAT GTCCAGATGG 8220

ATGTATAACA GGAGTATATA CTGATGCATA TCCACTCAAT CCCACAGGGA GCATTGTGTC 8280 ATCTGTCATA TTAGACTCAC AAAAATCGAG AGTGAACCCA GTCATAACTT ACTCAAGAGC 8340

AACCGAAAGA GTAAACGAGC TGGCCATCCT AAACAGAACA CTCTCAGCTG GATATACAAC 8400

AACAAGCTGC ATTACACACT ATAACAAAGG ATATTGTTTT CATATAGTAG AAATAAATCA 8460

TAAAAGCTTA AACACATTTC AACCCATGTT GTTCAAAACA GAGATTCCAA AAAGCTGCAG 8520

TTAATCATAA TTAACCATAA TATGCATCAA TCTATCTATA ATACAAGTAT ATGATAAGTA 8580

ATCAGCAATC AGACAATAGA CAAAAGGGAA ATATAAAAAA CTTAGGAGCA AAGCGTGCTC 8640

GGGAAATGGA CACTGAATCT AACAATGGCA CTGTATCTGA CATACTCTAT CCTGAGTGTC 8700

ACCTTAACTC TCCTATCGTT AAAGGTAAAA TAGCACAATT ACACACTATT ATGAGTCTAC 8760

CTCAGCCTTA TGATATOGAT GACGACTCAA TACTAGTTAT CACTAGACAG AAAATAAAAC 8820

TTAATAAATT GGATAAAAGA CAACGATCTA TTAGAAGATT AAAATTAATA TTAACTGAAA 8880

AAGTGAATGA CTTAGGAAAA TACACATTTA TCAGATATCC AGAAATGTCA AAAGAAATGT 8940

TCAAATTATA TATACCTGGT ATTAACAGTA AAGTGACTGA ATTATTACTT AAAGCAGATA 9000

GAACATATAG TCAAATGACT GATGGATTAA GAGATCTATG GATTAATGTG CTATCAAAAT 9060

TAGCCTCAAA AAATGATGGA AGCAATTATG ATCTTAATGA AGAAATTAAT AATATATCGA 9120

AAGTTCACAC AACCTATAAA TCAGATAAAT GGTATAATCC ATTCAAAACA TGGTTTACTA 9180

TCAAGTATGA TATGAGAAGA TTACAAAAAG CTCGAAATGA GATCACTTTT AATGTTGGGA 9240

AGGATTATAA CTTGTTAGAA GACCAGAAGA ATTTCTTATT GATACATCCA GAATTGGTTT 9300

TGATATTAGA TAAACAAAAC TACAATGGTT ATCTAATTAC TCCTGAATTA GTATTGATGT 9360

ATTGTGACGT AGTCGAAGGC CGATGGAATA TAAGTGCATG TGCTAAGTTA GATCCAAAAT 9420

TACAATCTAT GTATCAGAAA GGTAATAACC TGTGGGAAGT GATAGATAAA TTGTTTCCAA 9480

TTATGGGAGA AAAGACATTT GATGTGATAT CGTTATTAGA ACGACTTGCA TTATCCTTAA 9540

TTCAAACTCA TGATCCTGTT AAACAACTAA GAGGAGCTTT TTTAAATCAT GTGTTATCCG 9600

AGATGGAATT AATATTTGAA TCTAGAGAAT CGATTAAGGA ATTTCTGAGT GTAGATTACA 9660

TTGATAAAAT TTTAGATATA TTTAATAAGT CTACAATAGA TGAAATAGCA GAGATTTTCT 9720

CTTTTTTTAG AACATTTGGG CATCCTCCAT TAGAAGCTAG TATTGCAGCA GAAAAGGTTA 9780

GAAAATATAT GTATATTGGA AAACAATTAA AATTTGACAC TATTAATAAA TGTCATGCTA 9840 AGTATTTTAG GAATCCAAAT TGGATGCAAT ATGCCTCTTT AATACCTGCT AGTGTTGGGG 11460

GATTCAATCA CATGGCCATG TCAAGATGTT TTGTAAGGAA TATTGGTGAT CCATCAGTTG 11520

CCGCATTGGC TGATATTAAA AGATTTATTA AGGCGAATCT ATTAGACCGA AGTGTTCTTT 11580

ATAGGATTAT GAATCAAGAA CCAGGTGAGT CATCTTTTTT TGACTGGGCT TCAGATCCAT 11640

ATTCATGCAA TTTACCACAA TCTCAAAATA TAACCACCAT GATAAAAAAT ATAACAGCAA 11700

GGAATGTATT ACAAGATTCA CCAAATCCAT TATTATCTGG ATTATTCACA AATACAATGA 11760

TAGAAGAAGA TGAAGAATTA GCTGAGTTCC TGATGGACAG GAAGGTAATT CTCCCTAGAG 11820

TTGCACATGA TATTCTAGAT AATTCTCTCA CAGGAATTAG AAATGCCATA GCTGGAATGT 11880

TAGATACGAC AAAATCACTA ATTCGGGTTG GCATAAATAG AGGAGGACTG ACATATAGTT 11940

TGTTGAGGAA AATCAGTAAT TACGATCTAG TACAATATGA AACACTAAGT AGGACTTTGC 12000

GACTAATTGT AAGTGATAAA ATCAAGTATG AAGATATGTG TTCGGTAGAC CTTGCCATAG 12060

CATTGCGACA AAAGATGTGG ATTCATTTAT CAGGAGGAAG GATGATAAGT GGACTTGAAA 12120

CGCCTGACCC ATTAGAATTA CTATCTGGGG TAGTAATAAC AGGATCAGAA CATTGTAAAA 12180

TATGTTATTC TTCAGATGGC ACAAACCCAT ATACTTGGAT GTATTTACCC GGTAATATCA 12240

AAATAGGATC AGCAGAAACA GGTATATCGT CATTAAGAGT TCCTTATTTT GGATCAGTCA 12300

CTGATGAAAG ATCTGAAGCA CAATTAGGAT ATATCAAGAA TCTTAGTAAA CCTGCAAAAG 12360

CCGCAATAAG AATAGCAATG ATATATACAT GGGCATTTGG TAATGATGAG ATATCTTGGA 12420

TGGAAGCCTC ACAGATAGCA CAAACACGTG CAAATTTTAC ACTAGATAGT CTCAAAATTT 12480

TAACACCGGT AGCTACATCA ACAAATTTAT CACACAGATT TAAGGATACT GCAACTCAGA 12540

TGAAATTCTC CAGTACATCA TTGATCAGAG TCAGCAGATT TATAACAATG TCCAATGATA 12600

ACATGTCTAT CAAAGAAGCT AATGAAACCA AAGATACTAA TCTTATTTAT CAAGAAATAA 12660

TGTTAACAGG ATTAAGTGTT TTCGAATATT TATTTAGATT AAAAGAAACC ACAGGACACA 12720

ACCCTATAGT TATGCATCTG CACATAGAAG ATGAGTGTTG TATTAAAGAA AGTTTTAATG 12780

ATGAACATAT TAATCCAGAG TCTACATTAG AATTAATTCG ATATCCTGAA AGTAATGAAT 12840

TTATTTATGA TAAAGACCCA CTCAAAGATG TGGACTTATC AAAACTTATG GTTATTAAAG 12900

ACCATTCTTA CACAATTGAT ATGAATTATT GGGATGATAC TGACATCATA CATGCAATTT 12960 CAATATGTAC TGCAATTACA ATAGCAGATA CTATGTCACA AAGAGATAAT AGTTATTGCA AATGATGATG ATATTAATAG CTCTTGACAT ACTTGTATTT CTCAAGACAT TTGGTGGATT ACACTCTTTA TAGTCTAAAA ATAGAAGGTA GGGATCTCAT CACTGAGAGA TACTTCCCAT TCAATATTAA AAGTATTATC AAGTATTCAA GAGGTTCTGG GATTGTGGAG TTTTAAACCC CTAGTCAAGA CCAGATAAAA CTTGCCCTAT CTATATGTGA TGAGAGAATG GTTGAATGGT GTATCACTTG AAATATACAT TTGCAAATGA TAGGAAACAA GCCTTTATTT CTAGACACCT CAGAAATTGC ATCTTTCGGA CCTAACCTGT TAAACTTAAC TATTGAAACA ATATCTTGAA TTAAATATTA AAGAAGACCC TATCTGGATT ATTAATTAAA TCGTTCCCAT CAACTGTAAC TCAAATATCT AAGGATTCGC GGTATTAGTC CACCTGAGGT TAGAAGATGA AAATATGCTG GATAACATTG TCAAAACTAT ATAATAAAGG GAATAAAATT AACAATTTCT GGGGACTAGC TTAAAATCAG ATCTATAACA AGTGATTCTG ATGATAATGA GTGGTTTGAC ACTTCCTCAA GGAGGGAATT ATCTATCGCA TCAACAGCAC TAGTTGTCTG AAAGCTCTTG AGTTATCACA ATAAAGACAA GGACAGGCTC TTCCTGGGAG AAGGAGCAGG ATGCCACATT AGGACCTGCA GTTAATTATT ATAATTCAGG TTGGTCAACG AGAATTGAAA ATATTTCCTT CAGAGGTATC GAAATGTGAC ACAGATTCTT AACAGGGTAA AAGTACTGTT CATGGATAGG AAATATGGAA TGTGAGAGCT TAATATGGAG TTGGATTAGT ACATTGTGAT ATGGAAGGAG CTATCGGTAA ATGAACATTA TAGTGTTATA AGAATTACAT ACTTGATTGG TTTCCAAAAT TATACCTACA ATCACTCCGA ATTGGTCTAG TATATTGGAA AGATGTAAGT ATAATATCAC TCAAAACTTC TAATCCTGCA TCAACAGAAT 14580

TATATCTAAT TTCGAAAGAT GCATATTGTA CTATAATGGA ACCTAGTGAA ATTGTTTTAT 14640

CAAAACTTAA AAGATTGTCA CTCTTGGAAG AAAATAATCT ATTAAAATGG ATCATTTTAT 14700

CAAAGAAGAG GAATAATGAA TGGTTACATC ATGAAATCAA AGAAGGAGAA AGAGATTATG 14760

GAATCATGAG ACCATATGAT ATGGCACTAC AAATCTTTGG ATTTCAAATC AATTTAAATC 14820

ATCTGGCGAA AGAATTTTTA TCAACCCCAG ATCTGACTAA TATCAACAAT ATAATCCAAA 14880

GTTTTCAGCG AACAATAAAG GATGTTTTAT TTGAATGGAT TAATATAACT CATGATGATA 14940

AGAGACATAA ATTAGGCGGA AGATATAACA TATTCCCACT GAAAAATAAG GGAAAGTTAA 15000

GACTGCTATC GAGAAGACTA GTATTAAGTT GGATTTCATT ATCATTATCG ACTCGATTAC 15060

TTACAGGTCG CTTTCCTGAT GAAAAATTTG AACATAGAGC ACAGACTGGA TATGTATCAT 15120

TAGCTGATAC TGATTTAGAA TCATTAAAGT TATTGTCGAA AAACATCATT AAGAATTACA 15180

GAGAGTGTAT AGGATCAATA TCATATTGGT TTCTAACCAA AGAAGTTAAA ATACTTATGA 15240

AATTGATTGG TGGTGCTAAA TTATTAGGAA TTCCCAGACA ATATAAAGAA CCCGAAGACC 15300

AGTTATTAGA AAACTACAAT CAACATGATG AATTTGATAT CGATTAAAAC ATAAATACAA 15360

TGAAGATATA TCCTAACCTT TATCTTTAAG CCTAGGAATA GACAAAAAGT AAGAAAAACA 15420

TGTAATATAT ATATACCAAA CAGAGTTCTT CTCTTGTTTG GT 15462 (2) INFORMATION FOR SEQ ID NO: 22:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2233 amino acidβ

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 22:

Met Aβp Thr Glu Ser Aβn Asn Gly Thr Val Ser Asp He Leu Tyr Pro

1 5 10 15

Glu Cys His Leu Aen Ser Pro He Val Lys Gly Lys He Ala Gin Leu 20 25 30

Hiβ Thr He Met Ser Leu Pro Gin Pro Tyr Aβp Met Asp Asp Asp Ser 35 40 45

He Leu Val He Thr Arg Gin Lys He Lys Leu Asn Lye Leu Asp Lys 50 55 60

Arg Gin Arg Ser He Arg Arg Leu Lys Leu He Leu Thr Glu Lys Val 65 70 75 80

Asn Asp Leu Gly Lys Tyr Thr Phe He Arg Tyr Pro Glu Met Ser Lys 85 90 95

Glu Met Phe Lys Leu Tyr He Pro Gly He Asn Ser Lys Val Thr Glu 100 105 110

Leu Leu Leu Lys Ala Asp Arg Thr Tyr Ser Gin Met Thr Asp Gly Leu 115 120 125

Arg Asp Leu Trp He Aen Val Leu Ser Lye Leu Ala Ser Lye Aβn Aβp 130 135 140

Gly Ser Aβn Tyr Asp Leu Aen Glu Glu He Asn Asn He Ser Lys Val 145 150 155 160

Hiβ Thr Thr Tyr Lye Ser Aβp Lye Trp Tyr Aβn Pro Phe Lys Thr Trp 165 170 175

Phe Thr He Lys Tyr Aβp Met Arg Arg Leu Gin Lye Ala Arg Aen Glu 180 185 190

He Thr Phe Aβn Val Gly Lye Aβp Tyr Aβn Leu Leu Glu Aβp Gin Lys 195 200 205

Asn Phe Leu Leu He His Pro Glu Leu Val Leu He Leu Aβp Lye Gin 210 215 220

Aen Tyr Aβn Gly Tyr Leu He Thr Pro Glu Leu Val Leu Met Tyr Cyβ 225 230 235 240

Aβp Val Val Glu Gly Arg Trp Aβn He Ser Ala Cys Ala Lys Leu Asp 245 250 255

Pro Lys Leu Gin Ser Met Tyr Gin Lye Gly Aβn Aβn Leu Trp Glu Val 260 265 270

He Aβp Lye Leu Phe Pro He Met Gly Glu Lys Thr Phe Asp Val He 275 280 285

Ser Leu Leu Glu Pro Leu Ala Leu Ser Leu He Gin Thr Hiβ Aβp Pro 290 295 300 Val Lys Gin Leu Arg Gly Ala Phe Leu Asn His Val Leu Ser Glu Met 305 310 315 320

Glu Leu He Phe Glu Ser Arg Glu Ser He Lys Glu Phe Leu Ser Val 325 330 335

Asp Tyr He Asp Lys He Leu Asp He Phe Asn Lys Ser Thr He Asp 340 345 350

Glu He Ala Glu He Phe Ser Phe Phe Arg Thr Phe Gly His Pro Pro 355 360 365

Leu Glu Ala Ser He Ala Ala Glu Lys Val Arg Lys Tyr Met Tyr He 370 375 380

Gly Lye Gin Leu Lye Phe Aep Thr He Asn Lys Cys His Ala He Phe 385 390 395 400

Cys Thr He He He Asn Gly Tyr Arg Glu Arg His Gly Gly Gin Trp 405 410 415

Pro Pro Val Thr Leu Pro Asp His Ala His Glu Phe He He Asn Ala 420 425 430

Tyr Gly Ser Asn Ser Ala He Ser Tyr Glu Asn Ala Val Asp Tyr Tyr 435 440 445

Gin Ser Phe He Gly He Lys Phe Asn Lys Phe He Glu Pro Gin Leu 450 455 460

Asp Glu Aβp Leu Thr He Tyr Met Lye Aβp Lys Ala Leu Ser Pro Lys 465 470 475 480

Lye Ser Asn Trp Asp Thr Val Tyr Pro Ala Ser Asn Leu Leu Tyr Arg 485 490 495

Thr Asn Ala Ser Asn Glu Ser Arg Arg Leu Val Glu Val Phe He Ala 500 505 510

Asp Ser Lys Phe Asp Pro His Gin He Leu Asp Tyr Val Glu Ser Gly 515 520 525

Asp Trp Leu Asp Asp Pro Glu Phe Asn He Ser Tyr Ser Leu Lys Glu 530 535 540

Lys Glu He Lys Gin Glu Gly Arg Leu Phe Ala Lys Met Thr Tyr Lys 545 550 555 560

Met Arg Ala Thr Gin Val Leu Ser Glu Thr Leu Leu Ala Aβn Aβn He 565 570 575 Gly Lys Phe Phe Gin Glu Asn Gly Met Val Lys Gly Glu He Glu Leu 580 585 590

Leu Lys Arg Leu Thr Thr He Ser He Ser Gly Val Pro Arg Tyr Asn 595 600 605

Glu Val Tyr Asn Asn Ser Lys Ser Hiβ Thr Aβp Aβp Leu Lys Thr Tyr 610 615 620

Aβn Lye He Ser Aen Leu Aβn Leu Ser Ser Aβn Gin Lye Ser Lye Lys 625 630 635 640

Phe Glu Phe Lys Ser Thr Asp He Tyr Asn Asp Gly Tyr Glu Thr Val 645 650 655

Ser Cys Phe Leu Thr Thr Asp Leu Lys Lys Tyr Cys Leu Asn Trp Arg 660 665 670

Tyr Glu Ser Thr Ala Leu Phe Gly Glu Thr Cys Asn Gin He Phe Gly 675 680 685

Leu Asn Lys Leu Phe Asn Trp Leu His Pro Arg Leu Glu Gly Ser Thr 690 695 700

He Tyr Val Gly Asp Pro Tyr Cys Pro Pro Ser Asp Lys Glu Hiβ He 705 710 715 720

Ser Leu Glu Asp His Pro Asp Ser Gly Phe Tyr Val His Asn Pro Arg 725 730 735

Gly Gly He Glu Gly Phe Cys Gin Lys Leu Trp Thr Leu He Ser He 740 745 750

Ser Ala He His Leu Ala Ala Val Arg He Gly Val Arg Val Thr Ala 755 760 765

Met Val Gin Gly Asp Asn Gin Ala He Ala Val Thr Thr Arg Val Pro 770 775 780

Asn Asn Tyr Asp Tyr Arg Val Lys Lys Glu He Val Tyr Lys Asp Val 785 790 795 800

Val Arg Phe Phe Asp Ser Leu Arg Glu Val Met Asp Aβp Leu Gly Hiβ 805 810 815

Glu Leu Lys Leu Asn Glu Thr He He Ser Ser Lys Met Phe He Tyr 820 825 830

Ser Lye Arg He Tyr Tyr Aep Gly Arg He Leu Pro Gin Ala Leu Lye 835 840 845

Ala Leu Ser Arg Cyβ Val Phe Trp Ser Glu Thr Val He Aβp Glu Thr 850 855 860

Arg Ser Ala Ser Ser Asn Leu Ala Thr Ser Phe Ala Lys Ala He Glu 865 870 875 880

Asn Gly Tyr Ser Pro Val Leu Gly Tyr Ala Cys Ser He Phe Lys Aβn 885 890 895

He Gin Gin Leu Tyr He Ala Leu Gly Met Asn He Asn Pro Thr He 900 905 910

Thr Gin Asn He Arg Asp Gin Tyr Phe Arg Asn Pro Asn Trp Met Gin 915 920 925

Tyr Ala Ser Leu He Pro Ala Ser Val Gly Gly Phe Asn His Met Ala 930 935 940

Met Ser Arg Cys Phe Val Arg Asn He Gly Asp Pro Ser Val Ala Ala 945 950 955 960

Leu Ala Asp He Lys Arg Phe He Lys Ala Asn Leu Leu Asp Arg Ser 965 970 975

Val Leu Tyr Arg He Met Asn Gin Glu Pro Gly Glu Ser Ser Phe Phe 980 985 990

Asp Trp Ala Ser Asp Pro Tyr Ser Cys Asn Leu Pro Gin Ser Gin Asn 995 1000 1005

He Thr Thr Met He Lys Asn He Thr Ala Arg Asn Val Leu Gin Asp 1010 1015 1020

Ser Pro Asn Pro Leu Leu Ser Gly Leu Phe Thr Asn Thr Met He Glu 1025 1030 1035 1040

Glu Asp Glu Glu Leu Ala Glu Phe Leu Met Asp Arg Lys Val He Leu 1045 1050 1055

Pro Arg Val Ala His Aβp He Leu Aβp Aβn Ser Leu Thr Gly He Arg 1060 1065 1070

Asn Ala He Ala Gly Met Leu Asp Thr Thr Lys Ser Leu He Arg Val 1075 1080 1085

Gly He Asn Arg Gly Gly Leu Thr Tyr Ser Leu Leu Arg Lys He Ser 1090 1095 1100

Asn Tyr Asp Leu Val Gin Tyr Glu Thr Leu Ser Arg Thr Leu Arg Leu 1105 1110 1115 1120

He Val Ser Asp Lys He Lys Tyr Glu Asp Met Cys Ser Val Asp Leu 1125 1130 1135 Ala He Ala Leu Arg Gin Lys Met Trp He His Leu Ser Gly Gly Arg 1140 1145 1150

Met He Ser Gly Leu Glu Thr Pro Asp Pro Leu Glu Leu Leu Ser Gly 1155 1160 1165

Val Val He Thr Gly Ser Glu His Cys Lys He Cys Tyr Ser Ser Asp 1170 1175 1180

Gly Thr Aβn Pro Tyr Thr Trp Met Tyr Leu Pro Gly Aβn He Lye He 1185 1190 1195 1200

Gly Ser Ala Glu Thr Gly He Ser Ser Leu Arg Val Pro Tyr Phe Gly 1205 1210 1215

Ser Val Thr Asp Glu Arg Ser Glu Ala Gin Leu Gly Tyr He Lys Asn 1220 1225 1230

Leu Ser Lys Pro Ala Lys Ala Ala He Arg He Ala Met He Tyr Thr 1235 1240 1245

Trp Ala Phe Gly Asn Asp Glu He Ser Trp Met Glu Ala Ser Gin He 1250 1255 1260

Ala Gin Thr Arg Ala Asn Phe Thr Leu Asp Ser Leu Lys He Leu Thr 1265 1270 1275 1280

Pro Val Ala Thr Ser Thr Asn Leu Ser His Arg Phe Lys Asp Thr Ala 1285 1290 1295

Thr Gin Met Lys Phe Ser Ser Thr Ser Leu He Arg Val Ser Arg Phe 1300 1305 1310

He Thr Met Ser Asn Asp Asn Met Ser He Lys Glu Ala Asn Glu Thr 1315 1320 1325

Lys Aβp Thr Aβn Leu He Tyr Gin Gin He Met Leu Thr Gly Leu Ser 1330 1335 1340

Val Phe Glu Tyr Leu Phe Arg Leu Lys Glu Thr Thr Gly His Asn Pro 1345 1350 1355 1360

He Val Met His Leu His He Glu Asp Glu Cys Cys He Lys Glu Ser 1365 1370 1375

Phe Asn Asp Glu His He Asn Pro Glu Ser Thr Leu Glu Leu He Arg 1380 1385 1390

Tyr Pro Glu Ser Asn Glu Phe He Tyr Asp Lye Asp Pro Leu Lye Aβp 1395 1400 1405 Val Asp Leu Ser Lys Leu Met Val He Lys Asp His Ser Tyr Thr He 1410 1415 1420

Aβp Met Aβn Tyr Trp Aβp Aβp Thr Aβp He He Hiβ Ala He Ser He 1425 1430 1435 1440

Cyβ Thr Ala He Thr He Ala Aβp Thr Met Ser Gin Leu Asp Arg Aβp 1445 1450 1455

Aβn Leu Lye Glu He He Val He Ala Aβn Aβp Aβp Aβp He Aβn Ser 1460 1465 1470

Leu He Thr Glu Phe Leu Thr Leu Asp He Leu Val Phe Leu Lys Thr 1475 1480 1485

Phe Gly Gly Leu Leu Val Asn Gin Phe Ala Tyr Thr Leu Tyr Ser Leu 1490 1495 1500

Lys He Glu Gly Arg Aβp Leu He Trp Asp Tyr He Met Arg Thr Leu 1505 1510 1515 1520

Arg Aβp Thr Ser Hie Ser He Leu Lye Val Leu Ser Aβn Ala Leu Ser 1525 1530 1535

Hiβ Pro Lye Val Phe Lys Arg Phe Trp Aβp Cye Gly Val Leu Aen Pro 1540 1545 1550

He Tyr Gly Pro Asn He Ala Ser Gin Asp Gin He Lys Leu Ala Leu 1555 1560 1565

Ser He Cyβ Glu Tyr Ser Leu Asp Leu Phe Met Arg Glu Trp Leu Aβn 1570 1575 1580

Gly Val Ser Leu Glu He Tyr He Cyβ Aβp Ser Aβp Met Glu Val Ala 1585 1590 1595 1600

Asn Aβp Arg Lye Gin Ala Phe He Ser Arg Hie Leu Ser Phe Val Cyβ 1605 1610 1615

Cys Leu Ala Glu He Ala Ser Phe Gly Pro Asn Leu Leu Asn Leu Thr 1620 1625 1630

Tyr Leu Glu Arg Leu Asp Leu Leu Lys Gin Tyr Leu Glu Leu Asn He 1635 1640 1645

Lys Glu Asp Pro Thr Leu Lys Tyr Val Gin He Ser Gly Leu Leu He 1650 1655 1660

Lye Ser Phe Pro Ser Thr Val Thr Tyr Val Arg Lys Thr Ala He Lys 1665 1670 1675 1680

Tyr Leu Arg He Arg Gly He Ser Pro Pro Glu Val He Asp Aβp Trp 1685 1690 1695

Aβp Pro Val Glu Aβp Glu Asn Met Leu Asp Asn He Val Lys Thr He 1700 1705 1710

Aen Aβp Aβn Cyβ Asn Lys Aβp Asn Lys Gly Asn Lys He Asn Asn Phe 1715 1720 1725

Trp Gly Leu Ala Leu Lys Asn Tyr Gin Val Leu Lys He Arg Ser He 1730 1735 1740

Thr Ser Asp Ser Asp Asp Aβn Aβp Arg Leu Aβp Ala Aβn Thr Ser Gly 1745 1750 1755 1760

Leu Thr Leu Pro Gin Gly Gly Aβn Tyr Leu Ser Hiβ Gin Leu Arg Leu 1765 1770 1775

Phe Gly He Aβn Ser Thr Ser Cys Leu Lys Ala Leu Glu Leu Ser Gin 1780 1785 1790

He Leu Met Lys Glu Val Aβn Lys Asp Lys Asp Arg Leu Phe Leu Gly 1795 1800 1805

Glu Gly Ala Gly Ala Met Leu Ala Cys Tyr Asp Ala Thr Leu Gly Pro 1810 1815 1820

Ala Val Asn Tyr Tyr Aβn Ser Gly Leu Aβn He Thr Aβp Val He Gly 1825 1830 1835 1840

Gin Arg Glu Leu Lye He Phe Pro Ser Glu Val Ser Leu Val Gly Lye 1845 1850 1855

Lye Leu Gly Aβn Val Thr Gin He Leu Asn Arg Val Lys Val Leu Phe 1860 1865 1870

Asn Gly Asn Pro Asn Ser Thr Trp He Gly Asn Met Glu Cys Glu Ser 1875 1880 1885

Leu He Trp Ser Glu Leu Asn Asp Lys Ser He Gly Leu Val His Cys 1890 1895 1900

Asp Met Glu Gly Ala He Gly Lye Ser Glu Glu Thr Val Leu Hiβ Glu 1905 1910 1915 1920

His Tyr Ser Val He Arg He Thr Tyr Leu He Gly Asp Asp Asp Val 1925 1930 1935

Val Leu Val Ser Lys He He Pro Thr He Thr Pro Asn Trp Ser Arg 1940 1945 1950

He Leu Tyr Leu Tyr Lys Leu Tyr Trp Lys Asp Val Ser lie lie Ser 1955 1960 1965 Leu Lys Thr Ser Asn Pro Ala Ser Thr Glu Leu Tyr Leu He Ser Lys 1970 1975 1980

Aβp Ala Tyr Cyβ Thr He Met Glu Pro Ser Glu He Val Leu Ser Lye 1985 1990 1995 2000

Leu Lye Arg Leu Ser Leu Leu Glu Glu Aβn Aβn Leu Leu Lys Trp He 2005 2010 2015

He Leu Ser Lys Lys Arg Aβn Aβn Glu Trp Leu His His Glu He Lys 2020 2025 2030

Glu Gly Glu Arg Asp Tyr Gly He Met Arg Pro Tyr His Met Ala Leu 2035 2040 2045

Gin He Phe Gly Phe Gin He Aβn Leu Asn His Leu Ala Lys Glu Phe 2050 2055 2060

Leu Ser Thr Pro Asp Leu Thr Asn He Asn Asn He He Gin Ser Phe 2065 2070 2075 2080

Gin Arg Thr He Lys Asp Val Leu Phe Glu Trp He Asn He Thr His 2085 2090 2095

Asp Asp Lys Arg His Lys Leu Gly Gly Arg Tyr Asn He Phe Pro Leu 2100 2105 2110

Lys Asn Lys Gly Lys Leu Arg Leu Leu Ser Arg Arg Leu Val Leu Ser 2115 2120 2125

Trp He Ser Leu Ser Leu Ser Thr Arg Leu Leu Thr Gly Arg Phe Pro 2130 2135 2140

Asp Glu Lys Phe Glu His Arg Ala Gin Thr Gly Tyr Val Ser Leu Ala 2145 2150 2155 2160

Asp Thr Asp Leu Glu Ser Leu Lys Leu Leu Ser Lys Aβn He He Lye 2165 2170 2175

Asn Tyr Arg Glu Cys He Gly Ser He Ser Tyr Trp Phe Leu Thr Lye 2180 2185 2190

Glu Val Lye He Leu Met Lye Leu He Gly Gly Ala Lys Leu Leu Gly 2195 2200 2205

He Pro Arg Gin Tyr Lys Glu Pro Glu Asp Gin Leu Leu Glu Asn Tyr 2210 2215 2220

Asn Gin His Asp Glu Phe Aβp He Asp 2225 2230 (2) INFORMATION FOR SEQ ID NO: 23:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15218 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 23:

ACGCGAAAAA ATGCGTACTA CAAACTTGCA CATTCGAAAA AAATGGGGCA AATAAGAACT 60

TGATAAGTGC TATTTAAGTC TAACCTTTTC AATCAGAAAT GGGGTGCAAT TGACTGAGCA 120

TGATAAAGGT TAGATTAGAA AATTTATTTG ACAATGACGA AGTAGCATTG TTAAAAATAA 180

CATGTTATAC TGATAAATTA ATTCTTCTGA CCAATGCATT AGCCAAAGCA GCAATACATA 240

CAATTAAATT AAACGGCATA GTTTTTATAC ATGTTATAAC AAGCAGTGAA GTGTGCCCTG 300

ATAACAATAT TGTAGTGAAA TCTAACTTTA CAAGAATGCC AATACTACAA AATGGAGGAT 360

ACATATGGGA ATTGATTGAG TTGACACACT GCTCTCAATT AAACGGTTTA ATGGATGATA 420

ATTGTGAAAT CAAATTTTCT AAAAGACTAA GTGACTCAGT AATGACTAAT TATATGAATC 480

AAATATCTGA CTTACTTGGG CTTGATCTCA ATTCATGAAT TATGTTTAGT CTAATTCAAT 540

AGACATGTGT TTATTACCAT TTTAGTTAAT ATAAAAACTC ATCAAAGGGA AATGGGGCAA 600

ATAAACTCAC CTAATCAATC AAACCATGAG CACTACAAAT GAGAAGACTA CTATGCAAAG 660

ATTGATGATC ACAGACATGA GACCCCTGTC AATGGATTCA ATAATAACAT CTCTTACCAA 720

AGAAATCATC ACACAGAAAT TCATA ACTT GA AAACAAT GAATGTATTG TAAGAAAACT 780

TGATGAAAGA CAAGCTACAT TTAGATTCTT AGTCAATTAT GAGATGAAGC TACTGCACAA 840

AGTAGGGAGT ACCAAATACA AAAAATACAC TGAATATAAT ACAAAATATG GCACTTTCCC 900

CATGCCTATA TTTATCAATC ACGGCGGGTT TCTAGAATGT ATTGGCATTA AGCCTACAAA 960

ACACACTCCT ATAATATACA AATATGACCT CAACCCGTGA ATTCCAACAA AAAAACCAAC 1020

CCAACCAAAC CAAACTATTC CTCAAACAAC AGTGCTCAAT AGTTAAGAAG GAGCTAATCC 1080

ATTTTAGTAA TTAAAAATAA AAGTAAAGCC AATAACATAA ATTGGGGCAA ATACAAAGAT 1140 GGCTCTTAGC AAAGTCAAGT TGAATGATAC ATTAAATAAG GATCAGCTGC TGTCATCCAG 1200

CAAATACACT ATTCAACGTA GTACAGGAGA TAATATTGAC ACTCCCAATT ATGATGTGCA 1260

AAAACACCTA AACAAACTAT GTGGTATGCT ATTAATCACT GAAGATGCAA ATCATAAATT 1320

CACAGGATTA ATAGGTATGT TATATGCTAT GTCCAGGTTA GGAAGGGAAG ACACTATAAA 1380

GATACTTAAA GATGCTGGAT ATCATGTTAA AGCTAATGGA GTAGATATAA CAACATATCG 1440

TGAAGATATA AATGGAAAGG AAATGAAATT CGAAGTATTA ACATTATCAA GCTTGACATC 1500

AGAAATACAA GTCAATATTG AGATAGAATC TAGAAAGTCC TAGAAAAAAA TGCTAAAAGA 1560

GATGGGAGAA GTGGCTCCAG AATATAGGCA TGATTCTCCA GACTGTGGGA TGATAATACT 1620

GTGTATAGCT GCACTTGTGA TAACCAAATT AGCAGCAGGA GACAGATCAG GTCTTACAGC 1680

AGTAATTAGG AGGGCAAACA ATGTCTTAAA AAACGAAATA AAACGATACA AGGGCCTCAT 1740

ACCAAAGGAT ATAGCTAACA GTTTTTATGA AGTGTTTGAA AAACACCCTC ATCTTATAGA 1800

TGTTTTCGTG CACTTTGGCA TTGCACAATC ATCCACAAGA GGGGGTAGTA GAGTTGAAGG 1860

AATCTTTGCA GGATTGTTTA TGAATGCCTA TGGTTCAGGG CAAGTAATGC TAAGATGGGG 1920

AGTTTTAGCC AAATCTGTAA AAAATATCAT GCTAGGACAT GCTAGTGTCC AGGCAGAAAT 1980

GGAGCAAGTT GTGGAAGTCT ATGAGTATGC ACAGAAGTTG GGAGGAGAAG CTGGATTCTA 2040

CCATATATTG AAGAATCCAA AAGCATCATT GCTGTCATTA ACTCAATTTC CCAACTTCTC 2100

AAGTGTGGTC CTAGGCAATG CAGCAGGTCT AGGCATAATG GGAGAGTATA GAGGTACACC 2160

AAGAAACCAG GATCTTTATG ATGCAGCTAA AGCATATGCA GAGCAACTCA AAGAAAATGG 2220

AGTAATAAAC TACAGTGTAT TAGACTTAAC AGCAGAAGAA TTGGAAGCCA TAAAGCATCA 2280

ACTCAACCCC AAAGAAGATG ATGTAGAGCT TTAAGTTAAC AAAAAATACG GGGCAAATAA 2340

GTCAACATGG AGAAGTTTGC ACCTGAATTT CATGGAGAAG ATGCAAATAA CAAAGCTACC 2400

AAATTCCTAG AATCAATAAA GGGCAAGTTC GCATCATCCA AAGATCCTAA GAAGAAAGAT 2460

AGCATAATAT CTGTTAACTC AATAGATATA GAAGTAACTA AAGAGAGCCC GATAACATCT 2520

GGCACCAACA TCATCAATCC AACAAGTGAA GCCGACAGTA CCCCAGAAAC AAAAGCCAAC 2580

TACCCAAGAA AACCCCTAGT AAGCTTCAAA GAAGATCTCA CCCCAAGTGA CAACCCTTTT 2640

TCTAAGTTGT ACAAGGAAAC AATAGAAACA TTTGATAACA ATGAAGAAGA ATCTAGCTAC 2700 TCATATGAAG AGATAAATGA TCAAACAAAT GACAACATTA CAGCAAGACT AGATAGAATT 2760

GATGAAAAAT TAAGTGAAAT ATTAGGAATG CTCCATACAT TAGTAGTTGC AAGTGCAGGA 2820

CCCACTTCAG CTCGCGATGG AATAAGAGAT GCTATGGTTG GTCTAAGAGA AGAGATGATA 2880

GAAAAAATAA GAGCGGAAGC ATTAATGACC AATGATAGGT TAGAGGCTAT GGCAAGACTT 2940

AGGAATGAGG AAAGCGAAAA AATGGCAAAA GACACCTCAG ATGAAGTGTC TCTTAATCCA 3000

ACTTCCAAAA AATTGAGTGA CTTGTTGGAA GACAACGATA GTGACAATGA TCTATCACTT 3060

GATGATTTTT GATCAGCGAT CAACTCACTC AGCAATCAAC AACATCAATA AAACAGACAT 3120

CAATCCATTG AATCAACTGC CAGACCGAAC AAACAAACGT CCATCAGTAG AACCACCAAC 3180

CAATCAATCA ACCAATTGAT CAATCAGCAA CCCGACAAAA TTAACAATAT AGTAACAAAA 3240

AAAGAACAAG ATGGGGCAAA TATGGAAACA TACGTGAACA AGCTTCACGA AGGCTCCAGA 3300

TACACAGGAG CTGTTCAGTA CAATGTTCTA GAAAAAGATG ATGATCCTGC ATCACTAACA 3360

ATATGGGTGC CTATGTTCCA GTCATCTGTG CCAGCAGACT TGCTCATAAA AGAACTTGCA 3420

AGCATCAATA TACTAGTGAA GCAGATCTCT ACGCCCAAAG GACCTTCACT ACGAGTCACG 3480

ATTAACTCAA GAAGTGCTGT GCTGGCTCAA ATGCCTAGTA ATTTCATCAT AAGCGCAAAT 3540

GTATCATTAG ATGAAAGAAG CAAATTAGCA TATGATGTAA CTACACCTTG TGAAATCAAA 3600

GCATGCAGTC TAACATGCTT AAAAGTAAAA AGTATGTTAA CTACAGTCAA AGATCTTACC 3660

ATGAAGACAT TCAACCCCAC TCATGAGATC ATTGCTCTAT GTGAATTTGA AAATATTATG 3720

ACATCAAAAA GAGTAA AAT ACCAACCTAT CTAAGATCAA TTAGTGTCAA GAACAAGGAT 3780

CTGAACTCAC TAGAAAATAT AGCAACCACC GAATTCAAAA ATGCTATCAC CAATGCAAAA 3840

ATTATTCCTT ATGCAGGATT AGTGTTAGTT ATCACAGTTA CTGACAATAA AGGAGCATTC 3900

AAATATATCA AACCACAGAG TCAATTTATA GTAGATCTTG GTGCCTACCT AGAAAAAGAG 3960

AGGATATATT ATGTGACTAC TAATTGGAAG CATACAGCTA CACGTTTTTC AATCAAACCA 4020

CTAGAGGATT AAACTTAATT ATCAAGACTG AATGACAGGT CGACATATAT CCTCAAACTA 4080

CACACTATAT CGAAACATCA TAAACATCTA CACTACACAC TTCATCACAC AAACCAATCC 4140

CACTCAAAAT CCAAAATCAC TACCAGCCAC TATCTGCTAG ACCTAGAGTG CGAATAGGTA 4200

AATAAAACCA AAATATGGGG TAAATAGACA TTAGTTAGAG TTCAATGAAT CTTAACAACC 4260 ATTTATACCG CCAATTCAAC ACATATACTA TAAATCTTAA AATGGGAAAT ACATCCATCA 4320

CAATAGAATT CACAAGCAAA TTTTGGCCCT ATTTTACACT AATACATATG ATCTTAACTC 4380

TAATCTTTTT ACTAATTATA ATCACTATTA TGATTGCAAT ACTAAATAAG CTAAGTGAAC 4440

ATAAAGCATT CTGTAACAAA ACTCTTGAAC TAGGACAGAT GTATCAAATC AACACATAGA 4500

GTTCTACCAT TATGCTGTGT CAAATTATAA TCCTGTATAT ATAAACAAAC AAATCCAATC 4560

TTCTCACAGA GTCATGGTGT CGCAAAACCA CGCTAACTAT CATGGTAGCA TAGAGTAGTT 4620

ATTTAAAAAT TAACATAATG ATGAATTGTT AGTATGAGAT CAAAAACAAC ATTGGGGCAA 4680

ATGCAACCAT GTCCAAACAC AAGAATCAAC GCACTGCCAG GACTCTAGAA AAGACCTGGG 4740

ATACTCTTAA TCATCTAATT GTAATATCCT CTTGTTTATA CAGATTAAAT TTAAAATCTA 4800

TAGCACAAAT AGCACTATCA GTTTTGGCAA TGATAATCTC AACCTCTCTC ATAATTGCAG 4860

CCATAATATT CATCATCTCT GCCAATCACA AAGTTACACT AACAACGGTC ACAGTTCAAA 4920

CAATAAAAAA CCACACTGAA AAAAACATCA CCACCTACCC TACTCAAGTC TCACCAGAAA 4980

GGGTTAGTTC ATCGAAGCAA CCCACAACCA CATCACCAAT CCACACAAGT TGAGCTACAA 5040

CATCACCCAA TACAAAATCA GAAACACACC ATACAACAGC AGAAACGAAA GGCAGAACCA 5100

CCACTTCAAC ACAGACCAAC AAGCCAAGCA CAAAACCACG TCCAAAAAAT CCACCAAAAA 5160

AAGATGATTA CCATTTTGAA GTGTTCAACT TCGTTCCCTG CAGTATATGT GGCAACAATC 5220

AACTTTGCAA ATCCATCTGC AAAACAATAC CAAGCAACAA ACCAAAGAAG AAACGAACCA 5280

TCAAACCCAC AAACAAACCA ACCACCAAAA CCACAAACAA AAGAGACCCA AAAACACGAG 5340

CCAAAACGAC GAAAAAAGAA ACTACCACCA ACCCAACAAA AAAACTAACC CTCAAGACCA 5400

CAGAAAGAGA CACCAGCACC TCACAATCCA CTGCACTCGA CACAACCACA TTAAAACACA 5460

CAGTCCAACA GCAATCCCTC CTCTCAACCA CCCCCGAAAA CACACCCAAC TCCACACAAA 5520

CACCCACAGC ATCCGAGCCC TCCACACCAA ACTCCACCCA AAAAACCCAG CGACATGCTT 5580

AGTTATTCAA AAACTACATC TTAGCAGAGA ACCGTGATCT ATCAAGCAAG AACGAAATTA 5640

AACCTGGGGC AAATAACCAT GGAGTTGATG ATCCACAAGT CAAGTGCAAT CTTCCTAACT 5700

CTTGCTATTA ATGCATTGTA CCTCACCTCA AGTCAGAACA TAACTGAGGA GTTTTACCAA 5760

TCGACATGTA GTGCAGTTAG CAGAGGTTAT TTTAGTGCTT TAAGAACAGG TTGGTATACT 5820 AGTGTCATAA CAATAGAATT AAGTAATATA AAAGAAACCA AATGCAATGG AACTGACACT 5880

AAAGTAAAAC TTATGAAACA AGAATTAGAT AAGTATAAGA ATGCAGTAAC AGAATTACAG 5940

CTACTTATGC AAAAGACACC AGCTGTCAAC AACCGGGCCA GAAGAGAAGC ACCACAGTAT 6000

ATGAACTACA CAATGAATAC CACTAAAAAC CTAAATGTAT CAATAAGCAA GAAGAGGAAA 6060

CGAAGATTTC TAGGCTTCTT GTTAGGTGTG GGATCTGCAA TAGCAAGTGG TATAGCTGTA 6120

TCAAAAGTTC TACACCTTGA AGGAGAAGTG AACAAGATCA AAAATGCTTT GTTGTCTACA 6180

AACAAAGCTG TAGTCAGTTT ATCAAATGGG GTCAGTGTTT TAACCAGCAA AGTGTTAGAT 6240

CTCAAGAATT ACATAAATAA CCAATTATTA CCCATAGTAA ATCAACAGAG CTGTCGCATC 6300

TCCAACATTG AAACAGTTAT AGAATTCCAG CAGAAGAACA GCAGATTGTT GGAAATCACC 6360

AGAGAATTTA GTGTCAATGC AGGTGTAACA ACACCTTTAA GCACTTACAT GTTGACAAAC 6420

AGTGAGTTAC TATCATTAAT CAATGATATG CCTATAACAA ATGATCAGAA AAAATTAATG 6480

TCAAGCAATG TTCAGATAGT AAGGCAAGAA AGTTATTCCA TCATGTCTAT AATAAAGGAA 6540

GAAGTCCTTG CATATGTTGT ACAGCTGCCT ATCTATGGTG TAATAGATAC ACCTTGCTGG 6600

AAATTGCACA GATCGCCTCT ATGCACTACC AACATCAAAG AAGGATCAAA TATTTGTTTA 6660

ACAAGGACTG ATAGAGGATG GTATTGTGAT AATGGAGGAT CAGTATCCTT CTTTCCACAG 6720

GCTGACACTT GTAAAGTACA GTCGAATCGA GTATTTTGTG ACACTATGAA CAGTTTGACA 6780

TTACCAAGTG AAGTCAGCCT TTGTAACACT GACATATTCA ATTCCAAGTA TGACTGCAAA 6840

ATTATGACAT CAAAAACAGA CATAAGCAGC TCAGTAATTA CTTCTCTTGG AGCTATAGTG 6900

TCATGCTATG GTAAAACTAA ATGCACTGCA TCGAACAAAA ATCGTGGGAT TATAAAGACA 6960

TTTTCTAATG GTTGTGACTA TGTGTCAAAC AAAGGAGTAG ATACTGTGTC AGTGGGCAAC 7020

ACTTTATACT ATGTAAACAA GCTGGAAGGC AAGAACCTTT ATGTAAAAGG GGAACCTATA 7080

ATAAATTACT ATGACCCTCT AGTGTTTCCT TCTGATGAGT TTGATGCATC AATATCTCAA 7140

GTCAATGAAA AAATCAATCA AAGTTTAGCT TTTATTCGTA GATCTGATGA ATTACTACAT 7200

AATGTAAATA CTGGCAAATC TACTAGAAAT ATTATGATAA CTACAATTAT TATAGTAATC 7260

ATTGTAGTAT TGTTATCATT AATAGCTATT GGTTTACTGT TGTATTGTAA AGCCAAAAAC 7320

ACACCAGTTA CACTAAGCAA AGACCAACTA AGTGGAATCA ATAATATTGC ATTCAGCAAA 7380 TAGACAAAAA ACCACCTGAT CATGTTTCAA CAAGAATCTG CTGACCACCA ATCCCAAATC 7440

AACTTACAAC AAATATTTCA ACATCACAGT ACAGGCTGAA TCATTTCCTC ACATCATGCT 7500

ACCCACATAA CTAAGCTAGA TCCTTAACTT ATAGTTACAT AAAAACCTCA AGTATCACAA 7560

TCAACCACTA AATCAACACA TCATTCACAA AATTAACAGC TGGGGCAAAT ATGTCGCGAA 7620

GAAATCCTTG TAAATTTGAG ATTAGAGGTC ATTGCTTGAA TGGTAGAAGA TGTCACTACA 7680

GTCATAATTA CTTTGAATGG CCTCCTCATG CATTACTAGT GAGGCAAAAC TTCATGTTAA 7740

ACAAGATACT CAAGTCAATG GACAAAAGCA TAGACACTTT GTCTGAAATA AGTGGAGCTG 7800

CTGAACTGGA TAGAACAGAA GAATATGCTC TTGGTATAGT TGGAGTGCTA GAGAGTTACA 7860

TAGGATCTAT AAACAACATA ACAAAACAAT CAGCATGTGT TGCTATGAGT AAACTTCTTA 7920

TTGAGATCAA TAGTGATGAC ATTAAAAAGC TTAGAGATAA TGAAGAACCC AATTCACCTA 7980

AGATAAGAGT GTACAATACT GTTATATCAT ACATTGAGAG CAATAGAAAA AACAACAAGC 8040

AAACCATCCA TCTGCTCAAG AGACTACCAG CAGACGTGCT GAAGAAGACA ATAAAGAACA 8100

CATTAGATAT CCACAAAAGC ATAACCATAA GCAATCCAAA AGAGTCAACT GTGAATGATC 8160

AAAATGACCA AACCAAAAAT AATGATATTA CCGGATAAAT ATCCTTGTAG TATATCATCC 8220

ATATTGATCT CAAGTGAAAG CATGGTTGCT AGATTCAATC ATAAAAACAT ATTACAATTT 8280

AACCATAACT ATTTGGATAA CCACCAGCGT TTATTAAATC ATATATTTGA TGAAATTCAT 8340

TGGACACCTA AAAACTTATT AGATGCCACT CAACAATTTC TCCAACATCT TAACATCCCT 8400

GAAGATATAT ATACAGTATA TATATTAGTG TCATAATGCT TGACCATAAC GACTCTATGT 8460

CATCCAACCA TAAAACTATT TTGATAAGGT TATGGGACAA AATGGATCCC ATTATTAATG 8520

GAAACTCTGC TAATGTGTAT CTAACTGATA GTTATTTAAA AGGTGTTATC TCTTTTTCAG 8580

AGTGTAATGC TTTAGGGAGT TATCTTTTTA ACGGCCCTTA TCTTAAAAAT GATTACACCA 8640

ACTTAATTAG TAGACAAAGC CCACTACTAG AGCATATGAA TCTTAAAAAA CTAACTATAA 8700

CACAGTCATT AATATCTAGA TATCATAAAG GTGAACTGAA ATTAGAAGAA CGAACTTATT 8760

TCCAGTCATT ACTTATGACA TATAAAAGTA TGTCCTCGTC TGAACAAATT GCTACAACTA 8820

ACTTACTTAA AAAAATAATA CGAAGAGCCA TAGAAATAAG TGATGTAAAG GTGTACGCCA 8880

TCTTGAATAA ACTAGGATTA AAGGAAAAGG ACAGAGTTAA GCCCAACAAT AATTCAGGTG 8940 ATGAAAACTC AGTACTTACA ACCATAATTA AAGATGATAT ACTTTCGGCT ATCAATCATA TACAAATTCA GACAAAAGTC ACTCAGTAAA TCAAAATATC CAACACTCTT GAAAAAATTG ATGTGTTCAA TGCAACATCC TCCATCATGG GGTTCAATTT ATATACAAAA TTAAATAACA TATTAACACA ATATCGATCA AAAGTCATGG GTTTATATTA ATAGATAATC AAACTTTAAG TGGTTTTCAG ATCAATATGG TTGTATCGTT TATCATAAAG GACTCAAAAA AATCACAACT ATCAATTTTT GACATGGAAA GACATCAGCC TTAGCAGATT AAATGTTTGC GGATAAGTAA TTGTTTAAAT ACATTAAACA AAAGCTTAGG GCTGAGATGT ATGTTGTGTT ATCACAATTA TTTCTTTATG GAGATTGTAT ACTGAAATTA AAGGCTTCTA CATAATAAAA GAAGTAGAGG GATTTATTAT GTCTTTAATT CAGAAGAAGA TCAATTTAGG AAACGATTTT ATAATAGCAT GCTAAATAAC CAGCTATTAA GGCTCAAAAG GACCTACTAT CAAGAGTATG TCACACTTTA CAGTGTCTGA TAATATCATA AATGGTAAAT GGATAATCCT ATTAAGTAAA TGATTAAGCT TGCAGGTGAT AATAATCTCA ATAACTTGAG TGAGCTATAT GAATCTTTGG ACATCCAATG GTCGATGAAA GACAAGCAAT GGATTCTGTA GTAATGAAAC TAAGTTCTAC TTATTAAGTA GTCTAAGTAC ATTAAGAGGT ATAGAATCAT AAAAGGGTTT GTAAATACCT ACAACAGATG GCCCACCTTA TTGTCCTACC TCTAAGATGG TTAAACTACT ATAAACTTAA TACTTATCCA AAATCACAGA AAATGATTTG ATTATTTTAT CAGGATTGCG GTTCTATCGT TGCCTAAAAA AGTGGATCTT GAAATGATAA TAAATGACAA AGCCATTTCA ATCTAATATG GACTAGTTTT CCTAGAAATT ACATGCCATC ACATATACAA AACATGAAAA GTTGAAGTTC TCTGAAAGCG ACAGATCGAG AAGAGTACTA TGAGAGATAA TAAATTCAAT GAATGCGATC TATACAATTG TGTAGTCAAT TCAACAACTC TAATCACGTG GTATCACTAA CTGGTAAAGA AAGAGAGCTC GAATGTTTGC TATGCAACCA GGTATGTTTA GGCAAATCCA AATCTTAGCA TAGCTGAAAA TATTTTACAA TTCTTCCCTG AGAGTTTGAC AAGATATGGT TTCAAAAGAT ATTAGAATTA AAAGCAGGAA TAAGCAACAA GTCAAATCGT TATAATGATA 10560

ACTACAACAA TTATATCAGT AAATGTTCTA TCATTACAGA TCTTAGCAAA TTCAATCAGG 10620

CATTTAGATA TGAAACATCA TGTATCTGCA GTGATGTATT AGATGAACTG CATGGAGTAC 10680

AATCTCTGTT CTCTTGGTTG CATTTAACAA TACCTCTTGT CACAATAATA TGTACATATA 10740

GACATGCACC TCCTTTCATA AAGGATCATG TTGTTAATCT TAATGAGGTT GATGAACAAA 10800

GTGGATTATA CAGATATCAT ATGGGTGGTA TTGAGGGCTG GTGTCAAAAA CTGTGGACCA 10860

TTGAAGCTAT ATCATTATTA GATCTAATAT CTCTCAAAGG GAAATTCTCT ATCACAGCTC 10920

TGATAAATGG TGATAATGAG TCAATTGATA TAAGCAAACC AGTTAGACTT ATAGAGGGTC 10980

AGACCCATGC ACAAGCAGAT TATTTGTTAG CATTAAATAG CCTTAAATTG TTATATAAAG 11040

AGTATGCAGG TATAGGCCAT AAGCTTAAGG GAACAGAGAC CTATATATCC CGAGATATGC 11100

AGTTCATGAG CAAAACAATC CAGCAGAATG GAGTGTACTA TCCAGCCAGT ATCAAAAAAG 11160

TCCTGAGAGT AGGTCCATGG ATAAACACGA TACTTGATGA TTTTAAAGTT AGTTTAGAAT 11220

CTATAGGCAG CTTAACACAG GAGTTAGAAT ACAGAGGAGA AAGCTTATTA TGCAGTTTAA 11280

TATTTAGGAA CATTTGGTTA TACAATCAAA TTGCTTTGCA ACTCCGAAAT CATGCATTAT 11340

GTAACAATAA GCTATATTTA GATATATTGA AAGTATTAAA ACACTTAAAA ACTTTTTTTA 11400

ATCTTGATAG CATTGATATG GCTTTATCAT TGTATATGAA TTTGCCTATG CTGTTTGGTG 11460

GTGGTGATCC TAATTTGTTA TATCGAAGCT TTTATAGGAG AACTCCAGAC TTCCTTAGAG 11520

AAGCTATAGT ACATTCAGTG TTTGTGTTGA GCTATTATAC TGGTCACGAT TTACAAGATA 11580

AGCTCCAGGA TCTTCCAGAT GATAGACTGA ACAAATTCTT GACATGTGTC ATCACATTTG 11640

ATAAAAATCC CAATGCCGAG TTTGTAACAT TGATGAGGGA TCCACAGGCT TTAGGGTCTG 11700

AAAGGCAAGC TAAAATTACT AGTGAGATTA ATAGATTAGC AGTAACAGAA GTCTTAAGTA 11760

TAGCCCCAAA CAAAATATTT TCTAAAAGTG CACAACATTA TACTACCACT GAGATTGATC 11820

TAAATGACAT TATGCAAAAT ATAGAACCAA CTTACCCTCA TGGATTAAGA GTTGTTTATG 11880

AAAGTTTACC TTTTTATAAA GCAGAAAAAA TAGTTAATCT TATATCAGGA ACAAAATCCA 11940

TAACTAATAT ACTTGAAAAA ACATCAGCAA TAGATACAAC TGATATTAAT AGGGCTACTG 12000

ATATGATGAG GAAAAATATA ACTTTACTTA TAAGGATACT TCGACTAGAT TGTAACAAAG 12060 ACAAAAGAGA GTTATTAAGT TTAGAAAATC TTAGTATAAC TGAATTAAGC AAGTATGTAA 12120

GAGAAAGATC TTGGTCATTA TCCAATATAG TAGGAGTAAC ATCGCCAAGT ATTATGTTCA 12180

CAATGGACAT TAAATATACA ACTAGCACTA TAGCCAGTGG TATAATAATA GAAAAATATA 12240

ATGTTAATAG TTTAACTCGT GGTGAAAGAG GACCCACCAA GCCATGGGTA GGCTCATCCA 12300

CGCAGGAGAA AAAAACAATG CCAGTGTACA ACAGACAAGT TTTAACCAAA AAGCAAAGAG 12360

ACCAAATAGA TTTATTAGCA AAATTAGACT GGGTATATGC ATCCATAGAC AACAAAGATG 12420

AATTCATGGA AGAACTGAGT ACTGGAACAC TTGGACTGTC ATATGAAAAA GCCAAAAAGT 12480

TGTTTCCACA ATATCTAAGT GTCAATTATT TACACCGTTT AACAGTCAGT AGTAGACCAT 12540

GTGAATTCCC TGCATCAATA CCAGCTTATA GAACAACAAA TTATCATTTT GATACTAGTC 12600

CTATCAATCA TGTATTAACA GAAAAGTATG GAGATGAAGA TATCGACATT GTGTTTCAAA 12660

ATTGCATAAG TTTTGGTCTT AGCCTGATGT CGGTTGTGGA ACAATTCACA AACATATGTC 12720

CTAATAGAAT TATTCTGATA CCGAAGCTGA ATGAGATACA TTTGATGAAA CCTCCTATAT 12780

TTACAGGAGA TGTTGATATC ATCAAGTTGA AGCAAGTGAT ACAAAAGCAG CACATGTTCC 12840

TACCAGATAA AATAAGTTTA ACCCAATATG TAGAATTATT CTTAAGTAAC AAAGCACTTA 12900

AATCTGGATC TCACATCAAC TCTAATTTAA TATTAGTACA TAAAATGTCT GATTATTTTC 12960

ATAATGCTTA TATTTTAAGT ACTAATTTAG CTGGACATTG GATTCTGATT ATTCAACTTA 13020

TGAAAGATTC AAAAGGTATT TTTGAAAAAG ATTGGGGAGA GGGGTACATA ACTGATCATA 13080

TGTTCATTAA TTTGAATGTT TTCTTTAATG CTTATAAGAC TTATTTGCTA TGTTTTCATA 13140

AAGGTTATGG TAAAGCAAAA TTAGAATGTG ATATGAACAC TTGAGATCTT CTTTGTGTTT 13200

TGGAGTTAAT AGACAGTAGC TACTGGAAAT CTATGTCTAA AGTTTTCCTA GAACAAAAAG 13260

TCATAAAATA CATAGTCAAT CAAGACACAA GTTTGCGTAG AATAAAAGGC TGTCACAGTT 13320

TTAAGTTGTG GTTTTTAAAA CGCCTTAATA ATGCTAAATT TACCGTATGC CCTTGGGTTG 13380

TTAACATAGA TTATCACCCA ACACACATGA AAGCTATATT ATCTTAGATA GATTTAGTTA 13440

GAATGGGGTT AATAAATGTA GATAAATTAA CCATTAAAAA TAAAAACAAA TTCAATGATG 13500

AATTTTACAC ATCAAATCTC TTTTACATTA GT ATAACTT TTCAGACAAC ACTCATTTGC 13560

TAACAAAACA AATAAGAATT GCTAATTCAG AATTAGAAGA TAATTATAAC AAACTATATC 13620 ACCCAACCCC AGAAACTTTA GAAAATATGT CATTAATTCC TGTTAAAAGT AATAATAGTA 13680

ACAAACCTAA ATTTTGTATA AGTGGAAATA CCGAATCTAT GATGATGTCA ACATTCTCTA 13740

GTAAAATGCA TATTAAATCT TCCACTGTTA CCACAAGATT CAATTATAGC AAACAAGACT 13800

TGTACAATTT ATTTCCAATT GTTGTGATAG ACAAGATTAT AGATCATTCA GGTAATACAG 13860

CAAAATCTAA CGAACTTTAC ACCACCACTT CACATCAGAC ATCTTTAGTA AGGAATAGTG 13920

CATCACTTTA TTGCATGCTT CCTTGGCATC ATGTCAATAG ATTTAACTTT GTATTTAGTT 13980

CCACAGGATG CAAGATCAGT ATAGAGTATA TTTTAAAAGA TCTTAAGATT AAGGACCCCA 14040

GTTGTATAGC ATTCATAGGT GAAGGAGCTG GTAACTTATT ATTACGTACG GTAGTAGAAC 14100

TTCATCCAGA CATAAGATAC ATTTACAGAA GTTTAAAAGA TTGCAATGAT CATAGTTTAC 14160

CTATTGAATT TCTAAGGTTA TACAACGGGC ATATAAACAT AGATTATGGT GAGAATTTAA 14220

CCATTCCTGC TACAGATGCA ACTAATAACA TTCATTGGTC TTATTTACAT ATAAAATTTG 14280

CAGAACCTAT TAGCATCTTT GTCTGCGATG CTGAATTACC TGTTACAGCC AATTGGAGTA 14340

AAATTATAAT TGAATGGAGT AAGCATGTAA GAAAGTGCAA GTACTGTTCT TCTGTAAATA 14400

GATGCATTTT AATTGCAAAA TATCATGCTC AAGATGACAT TGATTTCAAA TTAGATAACA 14460

TTACTATATT AAAAACTTAC GTGTGCCTAG GTAGCAAGTT AAAAGGATCT GAAGTTTACT 14520

TAATCCTTAC AATAGGCCCT GCAAATATAC TTCCTGTTTT TGATGTTGTA CAAAATGCTA 14580

AATTGACACT TTCAAGAACT AAAAATTTCA TTATGCCTAA AAAAACTGAC AAGGAATCTA 14640

TCGATGCAAA TATTAAAAGC TTAATACCTT TCCTTTGTTA CCCTATAACA AAAAAAGGAA 14700

TTAAGACTTC ATTGTCAAAA TTGAAGAGTG TAGTTAATGG AGATATATTA TCATATTCTA 14760

TAGCTGGACG TAATGAAGTA TTCAGCAACA AGCTTATAAA CCACAAGCAT ATGAATATCC 14820

TAAAATGGCT AGATCATGTT TTAAATTTTA GATCAGCTGA ACTTAATTAC AATCATTTAT 14880

ACATGATAGA GTCCACATAT CCTTACTTAA GTGAATTGTT AAATAGTTTA ACAACCAATG 14940

AGCTCAAGAA GCTGATTAAA ATAACAGGTA GTGTGCTATA CAACCTTCCC AACGAACAGT 15000

AGTTTAAAAT ATCATTAACA AGTTTGGTCA AATTTAGATG CTAACACATC ATTATATTAT 15060

AGTTATTAAA AAATATACAA ACTTTTCAAT AATTTAGCAT ATTGATTCCA AAATTATCAT 15120

TTTAGTCTTA AGGGGTTAAA TAAAAGTCTA AAACTAACAA TTATACATGT GCATTCACAA 15180 CACAACGAGA CATTAGTTTT TGACACTTTT TTTCTCGT 15218

(2) INFORMATION FOR SEQ ID NO: 24:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 4:

Met Asp Pro He He Asn Gly Asn Ser Ala Asn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lys Gly Val He Ser Phe Ser Glu Cyβ Aen Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Aβn Gly Pro Tyr Leu Lye Aβn Aβp Tyr Thr Asn Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu Hiβ Met Aβn Leu Lye Lye Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr His Lys Gly Glu Leu Lys 65 70 75 80

Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lys He 100 105 110

He Arg Arg Ala He Glu He Ser Asp Val Lys Val Tyr Ala He Leu 115 120 125

Asn Lys Leu Gly Leu Lys Glu Lye Asp Arg Val Lys Pro Asn Asn Asn 130 135 140

Ser Gly Aep Glu Aβn Ser Val Leu Thr Thr He He Lys Asp Asp He 145 150 155 160

Leu Ser Ala Val Glu Asn Asn Gin Ser Tyr Thr Asn Ser Asp Lys Ser 165 170 175

His Ser Val Asn Gin Asn He Thr He Lys Thr Thr Leu Leu Lye Lys 180 185 190

Leu Met Cys Ser Met Gin Hiβ Pro Pro Ser Trp Leu He His Trp Phe 195 200 205

Asn Leu Tyr Thr Lys Leu Asn Asn He Leu Thr Gin Tyr Arg Ser Aβn 210 215 220

Glu Val Lys Ser His Gly Phe He Leu He Asp Aen Gin Thr Leu Ser 225 230 235 240

Gly Phe Gin Phe He Leu Aβn Gin Tyr Gly Cyβ He Val Tyr Hie Lye 245 250 255

Gly Leu Lye Lye He Thr Thr Thr Thr Tyr Aεn Gin Phe Leu Thr Trp 260 265 270

Lys Asp He Ser Leu Ser Arg Leu Asn Val Cys Leu He Thr Trp He 275 280 285

Ser Aβn Cys Leu Aβn Thr Leu Aβn Lys Ser Leu Gly Leu Arg Cys Gly 290 295 300

Phe Asn Aβn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Aβp Cyβ He 305 310 315 320

Leu Lys Leu Phe His Asn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Aβn He Thr Glu Glu Aβp Gin Phe 340 345 350

Arg Lys Arg Phe Tyr Asn Ser Met Leu Asn Asn He Thr Asp Ala Ala 355 360 365

He Lys Ala Gin Lys Asp Leu Leu Ser Arg Val Cys Hiβ Thr Leu Leu 370 375 380

Aβp Lys Thr Val Ser Asp Asn He He Asn Gly Lys Trp He He Leu 385 390 395 400

Leu Ser Lys Phe Leu Lys Leu He Lys Leu Ala Gly Asp Asn Asn Leu 405 410 415

Aβn Asn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly His Pro 420 425 430

Met Val Asp Glu Arg Gin Ala Met Asp Ser Val Arg He Asn Cyβ Aβn 435 440 445

Glu Thr Lys Phe Tyr Leu Leu Ser Ser Leu Ser Thr Leu Arg Gly Ala 450 455 460 Phe He Tyr Arg He He Lys Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Asn Tyr 485 490 495

Tyr Lys Leu Aen Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Aβn Aβp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe His Leu Pro 515 520 525

Lys Lye Val Aβp Leu Glu Met He He Aβn Aβp Lye Ala He Ser Pro 530 535 540

Pro Lye Aβp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

Hiβ He Gin Aβn Tyr He Glu Hiβ Glu Lye Leu Lye Phe Ser Glu Ser 565 570 575

Aβp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Aβp Aβn Lys Phe 580 585 590

Asn Glu Cys Asp Leu Tyr Asn Cys Val Val Aen Gin Ser Tyr Leu Aβn 595 600 605

Aβn Ser Aβn Hiβ Val Val Ser Leu Thr Gly Lys Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lys Met He Ala Glu Asn He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Asp Leu Glu Leu Gin Lys He Leu Glu 660 665 670

Leu Lys Ala Gly He Ser Asn Lys Ser Asn Arg Tyr Asn Asp Asn Tyr 675 680 685

Asn Asn Tyr He Ser Lys Cys Ser He He Thr Asp Leu Ser Lys Phe 690 695 700

Asn Gin Ala Phe Arg Tyr Glu Thr Ser Cys He Cyβ Ser Aβp Val Leu 705 710 715 720

Aβp Glu Leu His Gly Val Gin Ser Leu Phe Ser Trp Leu His Leu Thr 725 730 735 He Pro Leu Val Thr He He Cys Thr Tyr Arg His Ala Pro Pro Phe 740 745 750

He Lys Asp Hie Val Val Aβn Leu Aβn Glu Val Asp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr His Met Gly Gly He Glu Gly Trp Cys Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Aβp Leu He Ser Leu Lys Gly 785 790 795 800

Lys Phe Ser He Thr Ala Leu He Asn Gly Asp Asn Gin Ser He Asp 805 810 815

He Ser Lys Pro Val Arg Leu He Glu Gly Gin Thr His Ala Gin Ala 820 825 830

Asp Tyr Leu Leu Ala Leu Asn Ser Leu Lye Leu Leu Tyr Lye Glu Tyr 835 840 845

Ala Gly He Gly His Lys Leu Lys Gly Thr Glu Thr Tyr He Ser Arg 850 855 860

Asp Met Gin Phe Met Ser Lys Thr He Gin His Asn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lys Lys Val Leu Arg Val Gly Pro Trp He Asn Thr 885 890 895

He Leu Asp Asp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910

Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cys Ser Leu He Phe 915 920 925

Arg Aβn He Trp Leu Tyr Aβn Gin He Ala Leu Gin Leu Arg Aβn His 930 935 940

Ala Leu Cyβ Aβn Aβn Lye Leu Tyr Leu Asp He Leu Lys Val Leu Lys 945 950 955 960

His Leu Lys Thr Phe Phe Asn Leu Asp Ser He Asp Met Ala Leu Ser 965 970 975

Leu Tyr Met Asn Leu Pro Met Leu Phe Gly Gly Gly Asp Pro Asn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Asp Phe Leu Thr Glu Ala 995 1000 1005

He Val His Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly His Aβp Leu 1010 1015 1020

Gin Asp Lys Leu Gin Asp Leu Pro Asp Asp Arg Leu Asn Lys Phe Leu 1025 1030 1035 1040

Thr Cys Val He Thr Phe Asp Lye Asn Pro Asn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Asp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lys He 1060 1065 1070

Thr Ser Glu He Asn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Asn Lys He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Asn Asp He Met Gin Asn He Glu Pro Thr Tyr Pro His 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lys Ala Glu Lys 1125 1130 1135

He Val Asn Leu He Ser Gly Thr Lys Ser He Thr Asn He Leu Glu 1140 1145 1150

Lys Thr Ser Ala He Aβp Thr Thr Aβp He Aβn Arg Ala Thr Aβp Met 1155 1160 1165

Met Arg Lye Aβn He Thr Leu Leu He Arg He Leu Pro Leu Aep Cys 1170 1175 1180

Aβn Lye Aβp Lys Arg Glu Leu Leu Ser Leu Glu Asn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lys Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Asn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asp He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Asn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lys Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lys Lys Thr Met Pro Val Tyr Asn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lys Lys Gin Arg Asp Gin He Asp Leu Leu Ala Lys Leu Asp 1285 1290 1295 Trp Val Tyr Ala Ser He Asp Asn Lys Aβp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lye Ala Lye Lye Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Aβn Tyr Leu Hiβ Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cye Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Asn 1345 1350 1355 1360

Tyr His Phe Asp Thr Ser Pro He Asn His Val Leu Thr Glu Lys Tyr 1365 1370 1375

Gly Asp Glu Aβp He Aβp He Val Phe Gin Aβn Cyβ He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Aβn He Cyβ Pro Asn 1395 1400 1405

Arg He He Leu He Pro Lys Leu Asn Glu He His Leu Met Lys Pro 1410 1415 1420

Pro He Phe Thr Gly Asp Val Asp He He Lye Leu Lye Gin Val He 1425 1430 1435 1440

Gin Lys Gin His Met Phe Leu Pro Asp Lys He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Asn Lys Ala Leu Lys Ser Gly Ser Hiβ He 1460 1465 1470

Asn Ser Asn Leu He Leu Val His Lys Met Ser Asp Tyr Phe His Asn 1475 1480 1485

Ala Tyr He Leu Ser Thr Asn Leu Ala Gly His Trp He Leu He He 1490 1495 1500

Gin Leu Met Lys Asp Ser Lys Gly He Phe Glu Lys Aβp Trp Gly Glu 1505 1510 1515 1520

Gly Tyr He Thr Aβp Hiβ Met Phe He Aβn Leu Aβn Val Phe Phe Asn 1525 1530 1535

Ala Tyr Lys Thr Tyr Leu Leu Cys Phe His Lys Gly Tyr Gly Lys Ala 1540 1545 1550

Lys Leu Glu Cys Asp Met Asn Thr Ser Asp Leu Leu Cys Val Leu Glu 1555 1560 1565 Leu He Asp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580

Gin Lys Val He Lys Tyr He Val Aβn Gin Aβp Thr Ser Leu Arg Arg 1585 1590 1595 1600

He Lye Gly Cyβ Hiβ Ser Phe Lys Leu Trp Phe Leu Lys Arg Leu Asn 1605 1610 1615

Asn Ala Lys Phe Thr Val Cys Pro Trp Val Val Asn He Asp Tyr His 1620 1625 1630

Pro Thr Hiβ Met Lys Ala He Leu Ser Tyr He Asp Leu Val Arg Met 1635 1640 1645

Gly Leu He Asn Val Asp Lys Leu Thr He Lys Asn Lys Asn Lys Phe 1650 1655 1660

Aβn Aβp Glu Phe Tyr Thr Ser Aβn Leu Phe Tyr He Ser Tyr Asn Phe 1665 1670 1675 1680

Ser Asp Asn Thr His Leu Leu Thr Lye Gin He Arg He Ala Aβn Ser 1685 1690 1695

Glu Leu Glu Asp Asn Tyr Asn Lys Leu Tyr His Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Asn Met Ser Leu He Pro Val Lys Ser Asn Asn Ser Asn Lys 1715 1720 1725

Pro Lys Phe Cys He Ser Gly Asn Thr Glu Ser Met Met Met Ser Thr 1730 1735 1740

Phe Ser Ser Lye Met His He Lys Ser Ser Thr Val Thr Thr Arg Phe 1745 1750 1755 1760

Asn Tyr Ser Lys Gin Asp Leu Tyr Asn Leu Phe Pro He Val Val He 1765 1770 1775

Asp Lys He He Asp His Ser Gly Asn Thr Ala Lys Ser Asn Gin Leu 1780 1785 1790

Tyr Thr Thr Thr Ser Hiβ Gin Thr Ser Leu Val Arg Asn Ser Ala Ser 1795 1800 1805

Leu Tyr Cys Met Leu Pro Trp His His Val Asn Arg Phe Asn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cys Lye He Ser He Glu Tyr He Leu Lys Asp 1825 1830 1835 1840

Leu Lys He Lys Asp Pro Ser Cys He Ala Phe He Gly Glu Gly Ala 1845 1850 1855

Gly Asn Leu Leu Leu Arg Thr Val Val Glu Leu His Pro Aβp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lye Asp Cyβ Asn Asp His Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Asn Gly His He Asn He Aβp Tyr Gly Glu 1890 1895 1900

Aβn Leu Thr He Pro Ala Thr Aβp Ala Thr Aβn Asn He His Trp Ser 1905 1910 1915 1920

Tyr Leu His He Lys Phe Ala Glu Pro He Ser He Phe Val Cys Asp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Asn Trp Ser Lys He He He Glu Trp 1940 1945 1950

Ser Lys His Val Arg Lys Cys Lys Tyr Cys Ser Ser Val Asn Arg Cys 1955 1960 1965

He Leu He Ala Lys Tyr His Ala Gin Asp Asp He Asp Phe Lys Leu 1970 1975 1980

Aβp Asn He Thr He Leu Lys Thr Tyr Val Cys Leu Gly Ser Lys Leu 1985 1990 1995 2000

Lys Gly Ser Glu Val Tyr Leu He Leu Thr He Gly Pro Ala Aβn He 2005 2010 2015

Leu Pro Val Phe Aβp Val Val Gin Aβn Ala Lye Leu Thr Leu Ser Arg 2020 2025 2030

Thr Lye Asn Phe He Met Pro Lye Lys Thr Asp Lys Glu Ser He Aβp 2035 2040 2045

Ala Asn He Lye Ser Leu He Pro Phe Leu Cyβ Tyr Pro He Thr Lys 2050 2055 2060

Lys Gly He Lys Thr Ser Leu Ser Lys Leu Lys Ser Val Val Asn Gly 2065 2070 2075 2080

Asp He Leu Ser Tyr Ser He Ala Gly Arg Asn Glu Val Phe Ser Asn 2085 2090 2095

Lys Leu He Asn Hiβ Lye Hie Met Asn He Leu Lys Trp Leu Asp His 2100 2105 2110

Val Leu Asn Phe Arg Ser Ala Glu Leu Asn Tyr Asn His Leu Tyr Met 2115 2120 2125 He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Asn Ser Leu Thr 2130 2135 2140

Thr Asn Glu Leu Lys Lye Leu He Lye He Thr Gly Ser Val Leu Tyr 2145 2150 2155 2160 2165

(2) INFORMATION FOR SEQ ID NO: 25:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15229 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:25:

ACGCGAAAAA ATGCGTACTA CAAACTTGCA CATTCGGAAA AAATGGGGCA AATAAGAATT 60

TGATAAGTGC TATTTAAATC TAACCTTTTC AATCAGAAAT GGGGTGCAAT TGACTGAGCA 120

TGATAAAGGT TAGATTACAA AATTTATTTG ACAATGACGA AGTAGCATTG TTAAAAATAA 180

CATGTTATAC TGACAAATTA ATTCTTCTGA CCAATGCATT AGCCAAAGCA GTAATACATA 240

CAATTAAATT AAACGGCATA GTTTTTATAC ATGTTATAAC AAGCAGTGAA GTGTGCCCTG 300

ACAACAATAT TGTAGTGAAA TCTAACTTTA CAACAATGCC AATATTACAA AACGGAGGAT 360

ACATATGGGA ATTGATTGAG TTGACACACT GCTCTCAATC AAATGGTCTA ATGGATGATA 420

ATTGTGAAAT CAAATTTTCT AAAAGACTAA GTGACTCAGT AATGACTAAT TATATGAATC 480

AAATATCTGA TTTACTTGGG CTTGATCTCA ATTCATGAAT TATGTTTAGT CTAATTTAAT 540

AGACATGTGT TTATCACCAT TTTAGTTAAT ATAAAACCTC ATCAAAGGGA AATGGGGCAA 600

ATAAACTCAC CTAATCAGTC AAACCATGAG CACTACAAAT GACAACACTA CTATGCAAAG 660

ATTGATGATC ACAGACATGA GACCCCTGTC GATGGAATCA ATAATAACAT CTCTCACCAA 720

AGAAATCATA ACACACAAAT TCATATACTT GATAAACAAT GAATGTATTG TAAGAAAACT 780

TGATGAAAGA CAAGCTACAT TTACATTCTT AGTCAATTAT GAGATGAAGC TATTGCACAA 840 AGTAGGGAGT ACCAAATACA AGAAATACAC TGAATATAAT ACAAAATATG GCACTTTCCC 900

CATGCCTATA TTTATCAATC ATGACGGGTT TCTAGAATGT ATTGGCATTA AGCCTACAAA 960

ACACACTCCT ATAATATACA AATATGACCT CAACCCGTAA ATTCCAACAA AAAACTAACC 1020

CATCCAAACT AAGCTATTCC TCAAACAACA GTGCTCAACA GTTAAGAAGG AGCTAATCCA 1080

TTTTAGTAAT TAAAAATAAA GGCAGAGCCA ATAACATAAA TTGGGGCAAA TAGAAAGATG 1140

GCTCTTAGCA AAGTCAAGTT AAATGATACA TTAAATAAGG ATCAGCTGCT GTCATCCAGC 1200

AAATACACTA TTCAACGTAG TACAGGAGAT AATATTGAGA CTCCCAATTA TGATGTGCAA 1260

AAACACCTAA ACAAACTATG TGGTATGCTA TTAATCACTG AAGATGCAAA TCATAAATTC 1320

ACAGGATTAA TAGGTATGTT ATATGCTATG TCCAGGTTAG GAAGGGAAGA CACTATAAAG 1380

ATACTTAAAG ATGCTGGATA TCATGTTAAA GCTAATGGAG TAGATATAAC AACATATCGT 1440

CAAGATA AA ACGGAAAGGA AATGAAATTC GAAGTATTAA CATTATCAAG CTTGACATCA 1500

GAAATACAAG TCAATATTGA GATAGAATCT AGAAAGTCCT AGAAAAAAAT GCTAAAAGAG 1560

ATGGGAGAAG TGGCTCCAGA ATATAGGCAT GATTCTCCAG ACTGTGGGAT GATAATACTG 1620

TGTATAGCTG CACTTGTAAT AACCAAGTTA GCAGCAGGAG ATAGATCAGG TCTTACAGGA 1680

GTAATTAGGA GGGCAAACAA TGTCTTAAAA AACGAAATAA AACGCTACAA GGGCCTCATA 1740

CCAAAGGATA TAGCTAACAG TTTTTATGAA GTGTTTGAAA AACACCCTCA TCTTATAGAT 1800

GTTTTTGTGC ACTTTGGCAT TGCACAATCA TCCACAAGAG GGGGTAGTAG AGTTGAAGGA 1860

ATCTTTGCAG GATTATTTAT GAATGCCTAT GGTTCAGGGC AAGTAATGCT AAGATGGGGA 1920

GTTCTAGCCA AATCTGTAAA AAATATCATG CTAGGACATG CTAGTGTCCA GGCAGAAATG 1980

GAACAAGTTG TGGAAGTTTA TGAGTATGCA CAGAAGTTGG GAGGAGAAGC TGGATTCTAC 2040

CATATATTGA ACAATCCAAA AGCATCATTG CTGTCATTAA CTCAATTTCC TAACTTCTCA 2100

AGTGTGGTCC TAGGCAATGC AGGAGGTCTA GGCATAATGG GAGAGTATAG AGGTACACCA 2160

AGAAACCAAG ATCTATATGA TGCAGCCAAA GCATATGCAG AGCAACTCAA AGAAAATGGA 2220

GTAATAAACT ACAGTGTATT AGACTTAACA GCAGAAGAAT TGGAAGCCAT AAAGCATCAA 2280

CTCAACCCCA AAGAAGATGA TGTAGAGCTT TAAGTTAACA AAAAATACGG GGCAAATAAG 2340

TCAACATGGA GAAGTTTGCA CCTGAATTTC ATGGAGAAGA TGCAAACAAC AAAGCTACCA 2400 AATTCCTAGA ATCAATAAAG GGCAAGTTTG CATCATCCAA AGATCCTAAG AAGAAAGATA 2460

GCATAATATC TGTTAACTCA ATAGATATAG AAGTAACTAA AGAGAGCCCG ATAACATCTG 2520

GCACCAACAT CATCAATCCA ATAAGTGAAG CTGATAGTAC CCCAGAAGCT AAAGCCAACT 2580

ACCCAAGAAA ACCCCTAGTA AGCTTCAAAG AAGATCTCAC CCCAAGTGAC AACCCCTTTT 2640

CTAAGTTGTA CAAAGAAACA ATAGAAACAT TTGATAACAA TGAAGAAGAA TCTAGCTACT 2700

CATATGAAGA AATAAATGAT CAAACAAATG ACAACATTAC AGCAAGACTA GATAGAATTG 2760

ATGAAAAATT AAGTGAAATA TTAGGAATGC TCCATAGATT AGTAGTTGCA AGTGCAGGAC 2820

CCACCTCAGC TCGCGATGGA ATAAGAGATG CTATGGTTGG TCTAAGAGAA GAAATGATAG 2880

AAAAAATAAG AGCGGAAGCA TTAATGACCA ATGATAGGTT AGAGGCTATG GCAAGACTTA 2940

GGAATGAGGA AAGCGAAAAA ATGGCAAAAG ACACCTCAGA TGAAGTGTCT CTTAATCCAA 3000

CTTCCAAAAA ATTGAGTAAT TTGTTGGAAG ACAACGATAG TGACAATGAT CTATCACTTG 3060

ATGATTTTTG ATCAGTGATC AACTCACTGA GCAATGAACA ACATCAATGA AACAGACATC 3120

AATCCATTGA ATCAACTGCC AGACTGAACA CACAAACGTC CATCAGCAGA ACTACGAACC 3180

AATCAATCAA CCAATTGATC AATCAGCGAC CTAACAAAAT TAACAATATA GTAACAAAAA 3240

AAGAACAAGA TGGGGCAAAT ATGGAAACAT ACGTGAACAA GCTTCACGAG GGCTCCAGAT 3300

ACACAGCAGC TGTTCAGTAC AATGTTCTAG AAAAAGATGA TGATCCTGCA TCACTAACAA 3360

TATGGGTGCC TATGTTCCAG TCATCTGTGC CAGCAGACTT GCTCATAAAA GAACTTGCAA 3420

GCATCAACAT ACTAGTGAAG CAGATCTCCA CGCCCAAAGG ACCTTCACTA CGAGTCACGA 3480

TTAACTCAAG AAGTGCTGTG CTGGCAGAAA TGCCTAGTAG TTTTATCATA AGTGCAAATG 3540

TATCATTAGA TGAAAGAAGC AAATTAGCAT ATGATGTAAC TACACCTTGT GAAATCAAAG 3600

CATGCAGTCT AACATGCTTA AAAGTAAAAA GTATGTTAAC TACAGTCAAA GATCTTACCA 3660

TGAAAACATT CAATCCCACT CATGAGATTA TTGCTCTATG TGAATTTGAA AATATTATGA 3720

CATCAAAAAG AGTAATAATA CCAACCTATC TAAGATCAAT TAGTGTCAAA AACAAGGACC 3780

TGAACTCACT AGAAAATATA GCAACCACCG AATTCAAAAA TGCTATCACC AATGCGAAAA 3840

TTATTCCCTA TGCAGGATTA GTATTAGTTA TCACAGTTAC TGACAATAAA GGAGCATTCA 3900

AATATATGAA GCCACAGAGT CAATTTATAG TAGATCTTGG GGCCTACCTA GAAAAAGAGA 3960 GCATATATTA TGTGACTACA AATTGGAAGC ATACAGCTAC ACGTTTTTCA ATCAAACCAC 4020

TAGAGGATTA AACTTAATTA TCAACACTAA ATGACAGGTC CACATATATC TTCAAACTAT 4080

ACATTATATC CAAACATCAT GAGCATTTAC ACTACACACT TTTACCATAT AAATCAATCT 4140

CATTTAAAAT CGAAAATTAC TTCCAGCTAT CATCTGTTAG ACCTAGAGTG CGAATAGGTA 4200

AATAAAACCA AAATATGGGG TAAATAGACA TTAGTTAGAG TTCAATCAAT CTCAACAACC 4260

ATTTATACCG CCAATTCAGT ACATATACTA TAAATCTCAA AATGGGAAAT ACATCCATCA 4320

CAATAGAATT CACAAGCAAA TTTTGGCCTT ATTTTACACT AATACATATG ATCTTAACTC 4380

TAATCTCTTT ACTAATTATA ATCACTATTA TGATTGCAAT ACTAAATAAG CTAAGTGAAC 4440

ATAAAACATT CTGCAACAAA ACTCTTGAAC TAGGACAGAT GTATCAAATC AACACATAGT 4500

GTTCTACCAT TATGCTGTGT CAAATTATAA TCTTGTATAT ATAAACAAAC AAATCCAATC 4560

TTCTCACAGA GTCATGGTGG CGCAAAACCA CGCCAACCAT GATGATAGCA TAGAGTAGTT 4620

ATTTAAAAAT TAACATAATG ATGAATTATT GGTATGAGAT CAGGAACAAC ATTGGGGCAA 4680

ATGCAGCCAT GTCCAAGCAC AAGAATCGGC GCACTGCCGG GACTCTAGAA AGGACCTGGG 4740

ATACTCTTAA TCATCTAATT GTAATATCCT CTTGTTTATA CAGATTAAAT TTAAAATCTA 4800

TAGCACAAAT AGCACTGTCA GTTTTGGCAA TGATAATCTC AACCTCTCTC ATAATTGCAG 4860

CCATAATATT CATCATCTCT GCCAATCACA AAGTTACACT AACAACGGTT ACAGTTCAAA 920

CAATAAAAAA CGACACTGAA AAAAACATCT CCACCTACCT TACTCAAGTC CCACCAGAAA 4980

GGGTCAACTC ATCCAAACAA CCGACAACCA CATCACCAAT CCACACAAAT TCAGCCACAA 5040

TATCACCAAA TACAAAATCA GAAACACACC ATACAACAGC ACAAACCAAA GGCAGAATGA 5100

CCACTTCAAC ACAGACCAAC AAGCCAAGCA CAAAATCACG TTCAAAAAAT CCACCAAAAA 5160

AACCAAAAGA TGATTACCAT TTTGAAGTGT TCAATTTTGT TCCCTGTAGT ATATGTGGTA 5220

ATAATCAACT CTGCAAATCC ATCTGCAAAA CAATACCAAG CAACAAACCA AAGAAAAAAC 5280

CAACCATCAA ACCCACAAAC AAACCAACCA CCAAAACCAC AAACAAAAGA GACCCCAAAA 5340

CACCAGCCAA AATGCGAAAA AAAGAAATCA TCACCAACCC AGCAAAAAAA CCAACCCTCA 5400

AGACCACAGA AAGAGACACC AGCATTTCAC AATCCACCGT GCTCGACACA ATCACTCCAA 5460

AATACACAAT CCAACAGCAA TCCCTCCACT CAACCACCTC CGAAAACACA CCCAGCTCCA 5520 CACAAATACC CACAGCATCC GAGCCCTCCA CATTAAATCC TAATTAAAAA ACCTAGTCAC 5580

ATGCTTAGTT ATTCAAAAAC TACATCTTAG CAGAGAACCG TGATCTATCA AGCAAGAACA 5640

AAATTAAACC TGGGGCAAAT AACCATGGAG TTGCTGATCC AGAGGTCAAG TGGAATCTTC 5700

CTAACTCTTG CTGTTAATGC ATTGTACCTC ACCTCAAGTC AGAACATAAC TGAGGAGTTT 5760

TACCAATCGA CATGTAGTGC AGTTAGCAGA GGTTATTTTA GTGCTTTAAG AACAGGTTGG 5820

TATACCAGTG TCATAACAAT AGAATTAAGT AATATAAAAG AAACCAAATG CAATGGAACT 5880

GACACTAAAG TAAAACTTAT AAAACAAGAA TTAGATAAGT ATAAGAATGC AGTAACAGAA 5940

TTACAGCTAC TTATGCAAAA CACGCGAGCT GCCAACAACC GGGCCAGAAG AGAAGCACCA 6000

CAGTACATGA ACTACACAAT CAATACCACA AAAAACCTAA ATGTATCAAT AAGCAAGAAA 6060

AGGAAACGAA GATTTCTGGG CTTCTTGTTA GGTGTAGGAT CTGCAATAGC AAGTGGTATA 6120

GCTGTATCCA AAGTTTTACA CCTTGAAGGA GAAGTGAACA AAATCAAAAA TGCTTTGTTG 6180

TCTACAAACA AAGCTGTAGT CAGTCTATCA AATGGGGTCA GTGTTTTAAC CAGCAAAGTG 6240

TTAGATCTCA AGAATTACAT AAATAACCGA ATATTACCCA TAGTAAATCA ACAGAGCTGT 6300

CGCATCTCCA ACATTGAAAC AGTTATAGAA TTCCAGCAGA AGAATAGCAG ATTGTTGGAA 6360

ATCACCAGAG AATTTAGTGT TAATGCAGGT GTAACAACAC CTTTAAGCAC TTACATGTTA 6420

ACAAACAGTG AGTTACTATC ATTGATCAAT GATATGCCTA TAACAAATGA CGAGAAAAAA 6480

TTAATGTCAA GCAATGTTCA GATAGTAAGG CAACAAAGTT ATTCTATCAT GTCTATAATA 6540

AAGGAAGAAG TCCTTGCATA TGTTGTACAG CTACCTATCT ATGGTGTAAT AGATACACCT 6600

TGCTGGAAAT TACACACATC ACCTCTATGC ACCACCAACA TCAAAGAAGG ATCAAATATT 6660

TGTTTAACAA GGACTGATAG AGGATGGTAT TGTGATAATG CAGGATCAGT ATCCTTCTTC 6720

CCACAGGCTG ATACTTGCAA AGTACAGTCC AATCGAGTAT TTTGTGACAC TATGAACAGT 6780

TTAACATTAC CAAGTGAAGT CAGCCTTTGT AACACTGACA TATTCAATTC CAAGTATGAC 6840

TGCAAAATTA TGACATCAAA AACAGACATA AGCAGCTCAG TAATTACTTC TCTTGGAGCT 6900

ATAGTGTCAT GCTATGGAAA AACTAAATGC ACTGCATCCA ATAAAAATCG TGGGATTATA 6960

AAGACATTTT CTAATGGTTG TGACTATGTG TCAAACAAAG GAGTAGATAC TGTGTCAGTG 7020

GGCAACACTT TATACTATGT AAACAAGCTG GAAGGCAAAA ACCTTTATGT AAAAGGGGAA 7080 CCTATAATAA ATTACTATGA TCCTCTAGTG TTTCCTTCTG ATGAGTTTGA TGCATCAATA 7140

TCTCAAGTCA ATGAAAAAAT CAATCAAAGT TTAGCTTTTA TTCGTAGATC TGATGAATTA 7200

CTACATAATG TAAATACTGG CAAATCTACT ACAAATATTA TGATAACTAC AATTATTATA 7260

GTAATCATTG TAGTATTGTT ATCATTAATA GCTATTGGTT TACTGTTGTA TTGCAAAGCC 7320

AAAAACACAC GAGTTACACT AAGCAAAGAC CAACTAAGTG GAATCAATAA TATTGCATTC 7380

AGCAAATAGA CAAAAAACTA CTTAATCATG TTTCAACAAC AATCTGCTGA CCACCAATCC 7440

CAAATCAACT TAACAACAAA TATTTCAACA TCATAGCACA GGCTGAATCA TTTCCTCATA 7500

TCATGCTACC TACAGAACTA AGCTAGATCT TCAACTCATA GTTACATAAA AACCCCAAGT 7560

ATCACAATCA AACACTAAAT CGACACATCA TTCACAAAAT TAACAACTGG GGCAAATATG 7620

TCGCGAAGAA ATCCTTGTAA ATTTGAGATT AGAGGTCATT GCTTGAATGG TAGAAGATGT 7680

CACTACAGTC ATAATTATTT TGAATGGCCT CCTCATGCAT TACTAGTGAG GCAAAACTTC 7740

ATGTTAAACA AGATACTTAA GTCAATGGAC AAAAGCATAG ACACTTTGTC GGAAATAAGT 7800

GGAGCTGCTG AACTGGATAG AACAGAAGAA TATGCTCTTG GTATAGTTGG AGTGCTAGAG 7860

AGTTACATAG GATCAATAAA CAACATAACA AAACAATCAG CATGTGTTGC TATGAGTAAA 7920

CTTCTTATTG AGATCAACAG TGATGACATT AAAAAACTGA GAGATAACGA AGAACCCAAT 7980

TCGCCTAAGA TAAGAGTGTA CAATACTGTT ATATCATACA TTGAGAGCAA TAGAAAAAAC 8040

AACAAGCAAA CCATCCATCT GCTCAAAAGA CTACCAGCAG ACGTGCTGAA GAAGACAATA 8100

AAGAACACAT TAGATATCCA CAAAAGCATA ACCATAAGCA ACTCAAAAGA GTCAACCGTG 8160

AATGATCAAA ATGACCAAAC CAAAAATAAT GATATTACCG GATAAATATC CTTGTAGTAT 8220

ATCATCCATA TTGATTTCAA GTGAAAGCAT GATTGCTACA TTCAATCATA AAAACATATT 8280

ACAATTTAAC CATAACCATT TGGATAACCA CCAGTGTTTA TTAAATCATA TATTTGATGA 83 0

AATTCATTGG ACACCTAAAA ACTTATTAGA TGCCACTCAA CAATTTCTCC AACATCTTAA 8400

CATCCCTGAA GATATATATA CAGTATATAT ATTAGTGTCA TAATGCTTGA CCATAACAAT 8460

TTTATATCAT TCAACCATAA AACAACCTTA ATAAGGTTAT GGGACAAAAT GGATCCCATT 8520

ATTAATGGAA ACTCTGCCAA TGTGTATCTA ACTGATAGTT ATCTAAAAGG TGTTATCTCT 8580

TTTTCAGAAT GTAATGCTTT AGGGAGTTAC CTTTTTAACG GCCCCTATCT TAAAAATGAT 8640 TACACCAACT TAATTAGTAG ACAAAGCCCA CTACTAGAGC ATATGAATCT AAAAAAACTA 8700

ACTATAACAC AGTCATTAAT ATCTAGATAT CATAAAGGTG AACTGAAGTT AGAAGAACCA 8760

ACTTATTTCC AGTCATTACT TATGACATAT AAAAGTATGT CCTCGTCTGA ACAAATTGCT 8820

ACAACTAATT TACTTAAAAA AATAATACGA AGAGCTATAG AAATAAGTGA TGTAAAGGTG 8880

TACGCCATCT TGAATAAACT GGGACTAAAG GAAAAGGACA GAGTTAAGCC CAACAATAAT 8940

TCAGGTGATG AAAACTCAGT TCTTACAACC ATAATCAAAG ATGATATACT TTCAGCTGTG 9000

GAAAACAATC AATCATATAC AAATTCAGAC AAAAATCATT CAGTAAATCA AAATATCACT 9060

ATCAAAACAA CACTCTTGAA AAAATTGATG TGTTCAATGC AACATCCTCC ATCATGGTTA 9120

ATACACTGGT TGAATTTATA TACAAAATTA AATAACATAT TAAGACAATA TCGATCAAAT 9180

GAGGTAAAAA GTCATGGGTT TATATTAATA GATAATCAAA CTTTAAGTGA TTTTCAGTTT 9240

ATTTTAAATC AATATGGTTG TATCGTTTAT CATAAAGGAC TCAAAAAAAT CACAACTACT 9300

ACTTACAATC AATTTTTGAC ATGGAAAGAC ATCAGCCTTA GCAGATTAAA TGTTTGCTTA 9360

ATTACTTGGA TAAGTAATTG TTTAAATACA TTAAATAAAA GCTTAGGGCT GAGATGTGGA 9420

TTCAATAATG TTGTGTTATC ACAACTATTT CTTTATGGAG ATTGTATACT GAAATTATTC 9480

CATAATGAAG GCTTCTACAT AATAAAAGAA GTAGAGGGAT TTATTATGTC TTTAATTCTA 9540

AACATAACAG AAGAAGATGA ATTTAGGAAA CGATTTTATA ATAGCATGCT AAATAACATC 9600

ACAGATGCAG CTATTAAGGC TCAAAAAAAC CTACTATCAA GAGTATGTCA CACTTTATTA 9660

GACAAGACAG TGTCTGATAA TATCATAAAT GGTAAATGGA TAATCCTATT AAGTAAATTT 9720

CTTAAATTGA TTAAGCTTGC AGGTGATAAT AATCTCAATA ACTTGAGTGA GCTTTATTTT 9780

CTCTTCAGAA TCTTTGGACA TCCAATGGTC GATGAAAGAC AAGCAATGGA TGCTGTAAGA 9840

ATTAACTGTA ATGAAACCAA GTTCTACTTA TTAAGTAATC TAAGTACGTT AAGAGGTGCT 9900

TTCATTTATA GAATCATAAA GGGGTTTGTA AATACCTACA ACAGATGGCC CACTTTAAGG 9960

AATGCTATTG TTCTACCTCT AAGATGGTTG AACTATTATA AACTTAATAC TTATCCATCT 10020

CTACTTGAAA TCACAGAGAA AGATTTGATT ATTTTATCAG GATTGCGGTT CTATCGTGAG 10080

TTTCATCTGC CTAAAAAAGT GGATCTTGAA ATGATAATAA ATGACAAAGC CATTTCACCT 10140

CCAAAAGATT TAATATGGAC TAGTTTTCCT AGAAATTACA TGCCATCACA TATACAAAAT 10200 TATATAGAAC ATGAAAAGTT GAAGTTCTCT GAAAGTGACA GATCAAGAAG AGTACTAGAG 10260

TATTACTTGA GAGATAATAA ATTCAATGAA TGCGATCTAT ACAATTGTGT GGTCAATCAA 10320

AGCTATCTCA ACAACTCTAA CCATGTGGTA TCACTAACTG GTAAAGAAAG AGAGCTCAGT 10380

GTAGGTAGAA TGTTTGCTAT GCAACCAGGT ATGTTTAGGC AAATTCAAAT CTTAGCAGAG 10440

AAAATGATAG CCGAAAATAT TTTACAATTC TTCCCTGAGA GTTTGACAAG ATATGGTGAT 10500

CTAGAGCTTC AAAAGATATT AGAATTAAAA GCAGGAATAA GCAACAAGTC AAATCGTTAT 10560

AATGATAACT ACAACAATTA TATCAGTAAA TGTTCTATCA TTACAGACCT TAGCAAATTC 10620

AATCAAGCAT TTAGATATGA AACATGATGT ATCTGCAGTG ATGTATTAGA TGAACTGCAT 10680

GGAGTACAAT CTCTGTTCTC TTGGTTGCAT TTAACAATAC CTCTTGTCAC AATAATATGT 10740

ACATATAGAC ATGCACCTCC TTTTATAAAG GATCATGTTG TTAATCTTAA TAAAGTTGAT 10800

GAACAAAGTG GATTATACAG ATATCATATG GGTGGTATTG AAGGCTGGTG TGAAAAACTG 10860

TGGACCATTG AAGCTATATC ATTATTAGAT CTAATATCTC TCAAAGGGAA ATTCTCTATC 10920

ACAGCTCTAA TAAATGGTGA TAATCAGTCA ATTGATATAA GTAAACCAGT TAGACTTATA 10980

GAGGGTCAGA CCCATGCTCA AGCAGATTAT TTGTTAGCAT TAAATAGCCT TAAATTGCTA 11040

TATAAAGAGT ATGCGGGCAT AGGCCACAAG CTCAAGGGAA CAGAGACCTA TATATCCCGA 11100

GATATGCAAT TCATGAGCAA AACAATCCAG CACAATGGAG TGTACTATCC AGCCAGTATC 11160

AAAAAAGTCC TGAGAGTAGG TCCATGGATA AATACAATAC TTGATGATTT TAAAGTTAGT 11220

TTAGAATCTA TAGGTAGCTT AACACAGGAG TTAGAATATA GAGGAGAGAG CTTATTATGC 11280

AGTTTAATAT TTAGGAACAT TTGGTTATAC AATCAAATTG CTTTGCAACT CCGAAATCAT 11340

GCATTATGTC ACAATAAGCT ATATTTAGAT ATATTGAAAG TATTAAAACA CTTAAAAACT 11400

TTTTTTAATC TTGATAGTAT TGATATGGCT TTAACATTGT ATATGAATTT GCCTATGCTG 11460

TTTGGTGGTG GTGATCCTAA TTTGTTATAT CGAAGCTTTT ATAGGAGAAC TCCAGACTTC 11520

CTTACAGAAG CTATAGTACA TTCAGTGTTT GTGTTGAGCT ATTATACTGG TCACGATTTA 11580

CAAGATAAGC TCCAGGATCT TCCAGATGAT AGACTGAACA AATTCTTGAC ATGTATCATC 11640

ACGTTTGATA AAAATCCCAA TGCCGAGTTT GTAACATTGA TGAGAGATCC ACAGGCTTTA 11700

GGGTCTGAAA GGCAAGCAAA AATTACTAGT GAGATTAATA GATTAGCAGT GACAGAAGTC 11760 TTAAGTATAG CTCCAAACAA AATATTTTCT AAAAGTGCAC AACATTATAC TACCACTGAG 11820

ATTGATCTAA ATGATATTAT GCAAAATATA GAACCAACTT ACCCTCATGG ATTAAGAGTT 11880

GTTTATGAAA GTTTACCTTT TTATAAAGCA GAAAAAATAG TTAATCTTAT ATCAGGAACA 11940

AAATCCATAA CTAATATACT TGAAAAAACA TCAGCAATAG ATTCAACTGA TATTAATAGG 12000

GCTACTGATA TGATGAGGAA AAATATAACT TTACTTATAA GGATACTTCC ACTAGATTGT 12060

AACAAAGACA AAAGAGAGTT ATTAAGTTTA GAAAATCTTA GTATAACTGA ATTAAGCAAG 12120

TATGTAAGAG AAAGATCTTG GTCGTTATCC AATATAGTAG GAGTAACATC GCCAAGTATT 12180

ATGTTCACAA TGGACATTAA ATATACAACT AGCACTATAG CCAGTGGTAT AATTATAGAA 12240

AAATATAATG TTAATAGTTT AACTCGTGGT GAAAGAGGAC CTACTAAGCC ATGGGTAGGT 12300

TCATCTACGC AGGAGAAAAA AACAATGCCA GTGTACAATA GACAAGTTTT AACCAAAAAG 12360

CAAAGAGACC AAATAGATTT ATTAGGAAAA TTAGACTGGG TATATGCATC CATAGACAAC 12420

AAAGATGAAT TCATGGAAGA ACTGAGTACT GGAACACTTG GACTGTCATA TGAGAAAGCC 12480

AAAAAATTGT TTCCACAATA TCTAAGTGTC AATTATTTAC ACCGCTTAAC AGTCAGTAGT 12540

AGACCATGTG AATTCCCTGC ATCAATACCA GCTTATAGAA CAACAAATTA TCATTTCGAT 12600

ACTAGTCCTA TCAACCATGT ATTAACAGAA AAGTATGGAG ATGAAGATAT CGACATTGTG 12660

TTTCAAAATT GCATAAGTTT TGGTCTTAGC TTAATGTCGG TTGTGGAACA ATTCACAAAC 12720

ATATGTCCTA ATAGAATTAT TCTCATACCG AAGCTGAATG AGATACATTT GATGAAACCT 12780

CCTATATTTA CAGGAGATGT TGATATCATC AAGTTGAAGC AAGTGATACA AAAACAGCAC 12840

ATGTTCCTAC CAGATAAAAT AAGTTTAACC CAATATGTAG AATTATTCCT AAGTAACAAA 12900

GCACTTAAAT CTGGATCTCA CATCAACTCT AATTTAATAT TAGTACATAA AATGTCTGAT 12960

TATTTTCATA ATGCTTATAT TTTAAGTACT AATTTAGCTG GACATTGGAT TCTGATTATT 13020

CAACTTATGA AGGATTCAAA AGGTATTTTT GAAAAAGATT GGGGAGAGGG GTATATAACT 13080

GATCATATGT TCATTAATTT GAATGTTTTC TTTAATGCTT ATAAGACTTA TTTGCTATGT 13140

TTTCATAAAG GTTATGGTAA AGCAAAATTA GAATGTGATA TGAACACTTC AGATCTTCTT 13200

TGTGTTTTGG AGCTAATAGA CAGTAGCTAC TGGAAATCTA TGTCTAAAGT TTTCCTAGAA 13260

CAAAAAGTCA TAAAATACAT AATCAATCAA GAGACAAGTT TGCATAGAAT AAAAGGTTGT 13320 CATAGTTTTA AGTTATGGTT TTTAAAACGC CTTAATAATG CTAAATTTAC CGTATGCCCT 13380

TGGGTTGTTA ACATAGATTA TCACCCAACA CACATGAAAG CTATATTATC TTACATAGAT 13440

TTAGTTAGAA TGGGGTTAAT AAATGTAGAT AAATTAACCA TTAAAAATAA AAATAAATTC 13500

AATGATGAAT TTTACACATC AAATCTCTTT TACATTAGTT ATAACTTTTC AGATAACACT 13560

CATTTGCTAA CAAAACAAAT AAGAATTGCT AATTCAGAAT TAGAAAATAA TTATAACAAA 13620

CTATATCACC CAACCCCAGA AACTTTAGAA AATATGTCAT TAATTCCTGT CAAAAGTAAT 13680

AATAGTAATA AACCTAAATT TGGTATAAGT GGAAATACCG AATCTATGAT GACGTCAACA 13740

TTCTCCAATA AAACGCATAT TAAATCTTCC GCTGTTATTA CAAGATTCAA TTATAGTAAA 13800

CAAGACTTGT ACAATTTATT TCCAATTGTC GTGATAGACA GGATTATAGA TCATTCAGGT 13860

AATACAGCAA AATCTAACCA ACTCTAGACT ACCACTTCAC ATCAGACATC TTTAGTAAGG 13920

AATAGTGCAT CACTTTATTG CATGCTTCCT TGGCATCATG TCAATAGATT TAACTTTGTA 13980

TTTAGTTCCA CAGGATGCAA GATCAGTATA GAGTATATTT TAAAAGATCT TAAGATTAAA 14040

GACCCCAGTT GTATAGCATT CATAGGTGAA GGAGCTGGTA ACTTATTATT ACGTACAGTA 14100

GTAGAACTTC ATCCAGACAT AAGATACATT TACAGAAGTT TAAAAGATTG CAATGATCAT 14160

AGTTTACCTA TTGAATTTCT AAGGTTATAC AACGGGCATA TAAACATAGA TTATGGTGAG 14220

AATTTAACCA TTCCTGCTAC AGATGCAACT AATAACATTC ATTGGTCTTA TTTACATATA 14280

AAATTTGCAG AACCTATTAG CATTTTTGTC TGCGATGCTG AATTACCTGT TACAGCCAAT 14340

TGGAGTAAAA TTATAATTGA ATGGAGTAAG CATGTAAGAA AGTGCAAGTA CTGTTCCTCT 14400

GTAAATAGAT GCATTTTAAT TGCAAAATAT CATGCCCAAG ATGATATTGA TTTCAAATTA 14460

GATAACATTA CTATATTAAA AACTTACGTG TGCCTAGGTA GCAAGTTAAA AGGATCTGAA 14520

GTTTACTTAG TCCTTACAAT AGGCCCTGCA AATATACTTC CTGTTTTTAA TGTTGTGCAA 14580

AATGCTAAAT TGATTCTTTC AAGGACTAAA AATTTCATTA TGCCTAAAAA AACTGACAAA 14640

GAATCTATCG ATGCAAATAT TAAAAGCTTA ATACCTTTCC TTTGTTACCC TATAACAAAA 14700

AAAGGAATTA AGACTTCATT GTCAAAATTG AAGAGTGTAG TTAGTGGAGA TATATTATCA 14760

TATTCTATAG CTGGACGTAA TGAAGTATTC AGCAACAAGC TTATAAACCA CAAGCATATG 14820

AATATCCTAA AATGGCTAGA TCATGTTTTA AACTTTAGAT CAGCTGAACT TAATTACAAT 14880 CATTTATATA TGATAGAGTC CACATATCCT TACTTAAGTG AATTGTTAAA CAGTTTAACA 14940

ACCAATGAGC TCAAGAAGCT GATTAAAATA ACAGGTAGTG TACTATACAA CCTTCCCAAC 15000

GAACAGTAAC TTAAAACATC ATTAACAAGT TTGATCAAAT TTAGATGCTA ACACATCATA 15060

ATATTATAGT TATTAAAAAA TATATATGCA AACTTTTCAA TAATTTAGCA TATTGATTCC 15120

AAAGTTATCA TTTTGGTCTT AAGGGGTTGA ATAAAAATCT AAAACTAACA ATTATACATG 15180

TGCATTTACA AGACAACGAG ACATTAGTTT TTGACACTTT TTTTCTCGT 15229 (2) INFORMATION FOR SEQ ID NO: 26:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 26:

Met Asp Pro He He Asn Gly Asn Ser Ala Asn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lys Gly Val He Ser Phe Ser Glu Cys Asn Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Asn Gly Pro Tyr Leu Lys Asn Aβp Tyr Thr Aβn Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu Hiβ Met Asn Leu Lys Lye Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr Hiβ Lys Gly Glu Leu Lys 65 70 75 80

Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lys He 100 105 110 lie Arg Arg Ala He Glu He Ser Aβp Val Lye Val Tyr Ala He Leu 115 120 125 Asn Lys Leu Gly Leu Lys Glu Lys Asp Arg Val Lys Pro Aβn Aβn Aβn 130 135 140

Ser Gly Asp Glu Asn Ser Val Leu Thr Thr He He Lys Asp Asp He 145 150 155 160

Leu Ser Ala Val Glu Asn Aβn Gin Ser Tyr Thr Aβn Ser Aβp Lys Asn 165 170 175

His Ser Val Asn Gin Asn He Thr He Lye Thr Thr Leu Leu Lys Lys 180 185 190

Leu Met Cys Ser Met Gin His Pro Pro Ser Trp Leu He Hiβ Trp Phe 195 200 205

Aβn Leu Tyr Thr Lye Leu Aβn Asn He Leu Thr Gin Tyr Arg Ser Asn 210 215 220

Glu Val Lys Ser Hiβ Gly Phe He Leu He Aβp Aβn Gin Thr Leu Ser 225 230 235 240

Asp Phe Gin Phe He Leu Aβn Gin Tyr Gly Cys He Val Tyr His Lys 245 250 255

Gly Leu Lys Lys He Thr Thr Thr Thr Tyr Asn Gin Phe Leu Thr Trp 260 265 270

Lye Aβp He Ser Leu Ser Arg Leu Aβn Val Cyβ Leu He Thr Trp He 275 280 285

Ser Aβn Cyβ Leu Aβn Thr Leu Aen Lye Ser Leu Gly Leu Arg Cyβ Gly 290 295 300

Phe Aβn Asn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Asp Cys He 305 310 315 320

Leu Lys Leu Phe His Asn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Asn He Thr Glu Glu Aβp Gin Phe 340 345 350

Arg Lye Arg Phe Tyr Asn Ser Met Leu Asn Asn He Thr Asp Ala Ala 355 360 365

He Lys Ala Gin Lys Asn Leu Leu Ser Arg Val Cys His Thr Leu Leu 370 375 380

Aβp Lys Thr Val Ser Asp Asn He He Asn Gly Lys Trp He He Leu 385 390 395 400

Leu Ser Lys Phe Leu Lys Leu He Lys Leu Ala Gly Asp Asn Asn Leu 405 410 415

Asn Asn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly His Pro 420 425 430

Met Val Asp Glu Arg Gin Ala Met Asp Ala Val Arg He Aen Cys Asn 435 440 445

Glu Thr Lye Phe Tyr Leu Leu Ser Aβn Leu Ser Thr Leu Arg Gly Ala 450 455 460

Phe He Tyr Arg He He Lys Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Asn Tyr 485 490 495

Tyr Lys Leu Aβn Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Lye Aβp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe Hiβ Leu Pro 515 520 525

Lye Lys Val Asp Leu Glu Met He He Asn Asp Lys Ala He Ser Pro 530 535 540

Pro Lys Asp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

His He Gin Asn Tyr He Glu His Glu Lye Leu Lye Phe Ser Glu Ser 565 570 575

Aβp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Asp Asn Lys Phe 580 585 590

Asn Glu Cys Asp Leu Tyr Asn Cys Val Val Asn Gin Ser Tyr Leu Asn 595 600 605

Asn Ser Asn His Val Val Ser Leu Thr Gly Lys Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lys Met He Ala Glu Asn He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Asp Leu Glu Leu Gin Lys He Leu Glu 660 665 670

Leu Lye Ala Gly He Ser Asn Lys Ser Aβn Arg Tyr Asn Asp Asn Tyr 675 680 685 Asn Asn Tyr He Ser Lys Cys Ser He He Thr Asp Leu Ser Lys Phe 690 695 700

Asn Gin Ala Phe Arg Tyr Glu Thr Ser Cys He Cys Ser Asp Val Leu 705 710 715 720

Aβp Glu Leu His Gly Val Gin Ser Leu Phe Ser Trp Leu Hiβ Leu Thr 725 730 735

He Pro Leu Val Thr He He Cyβ Thr Tyr Arg Hiβ Ala Pro Pro Phe 740 745 750

He Lye Aβp Hiβ Val Val Aβn Leu Aβn Lye Val Aβp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr Hiβ Met Gly Gly He Glu Gly Trp Cys Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Asp Leu He Ser Leu Lys Gly 785 790 795 800

Lys Phe Ser He Thr Ala Leu He Aβn Gly Aβp Aβn Gin Ser He Aβp 805 810 815

He Ser Lye Pro Val Arg Leu He Glu Gly Gin Thr Hiβ Ala Gin Ala 820 825 830

Aβp Tyr Leu Leu Ala Leu Asn Ser Leu Lys Leu Leu Tyr Lye Glu Tyr 835 840 845

Ala Gly He Gly His Lys Leu Lys Gly Thr Glu Thr Tyr He Ser Arg 850 855 860

Aβp Met Gin Phe Met Ser Lye Thr He Gin Hiβ Aβn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lye Lye Val Leu Arg Val Gly Pro Trp He Aβn Thr 885 890 895

He Leu Aβp Aβp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910

Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cys Ser Leu He Phe 915 920 925

Arg Asn He Trp Leu Tyr Asn Gin He Ala Leu Gin Leu Arg Asn His 930 935 940

Ala Leu Cyβ Hiβ Aβn Lye Leu Tyr Leu Asp He Leu Lys Val Leu Lys 945 950 955 960 Hiβ Leu Lys Thr Phe Phe Asn Leu Asp Ser He Asp Met Ala Leu Thr 965 970 975

Leu Tyr Met Asn Leu Pro Met Leu Phe Gly Gly Gly Asp Pro Asn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Asp Phe Leu Thr Glu Ala 995 1000 1005

He Val His Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly Hiβ Aβp Leu 1010 1015 1020

Gin Aβp Lys Leu Gin Asp Leu Pro Asp Asp Arg Leu Aβn Lys Phe Leu 1025 1030 1035 1040

Thr Cys He He Thr Phe Asp Lys Asn Pro Asn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Asp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lys He 1060 1065 1070

Thr Ser Glu He Asn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Asn Lys He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Asn Asp He Met Gin Aβn He Glu Pro Thr Tyr Pro Hiβ 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lye Ala Glu Lys 1125 1130 1135

He Val Asn Leu He Ser Gly Thr Lys Ser He Thr Asn He Leu Glu 1140 1145 1150

Lys Thr Ser Ala He Asp Ser Thr Asp He Asn Arg Ala Thr Asp Met 1155 1160 1165

Met Arg Lys Aβn He Thr Leu Leu He Arg He Leu Pro Leu Aβp Cyβ 1170 1175 1180

Aβn Lys Asp Lye Arg Glu Leu Leu Ser Leu Glu Asn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lys Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Asn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asp He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Aβn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lys Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lys Lys Thr Met Pro Val Tyr Asn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lye Lye Gin Arg Aβp Gin He Asp Leu Leu Ala Lys Leu Aβp 1285 1290 1295

Trp Val Tyr Ala Ser He Asp Asn Lye Aβp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lye Ala Lye Lys Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Aβn Tyr Leu His Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cys Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Asn 1345 1350 1355 1360

Tyr His Phe Asp Thr Ser Pro He Asn His Val Leu Thr Glu Lys Tyr 1365 1370 1375

Gly Asp Glu Asp He Asp He Val Phe Gin Asn Cys He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Aβn He Cys Pro Asn 1395 1400 1405

Arg He He Leu He Pro Lys Leu Asn Glu He His Leu Met Lye Pro 1410 1415 1420

Pro He Phe Thr Gly Aep Val Asp He He Lys Leu Lys Gin Val He 1425 1430 1435 1440

Gin Lys Gin Hiβ Met Phe Leu Pro Asp Lys He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Asn Lys Ala Leu Lys Ser Gly Ser His He 1460 1465 1470

Asn Ser Asn Leu He Leu Val His Lys Met Ser Asp Tyr Phe His Asn 1475 1480 1485

Ala Tyr He Leu Ser Thr Aβn Leu Ala Gly Hiβ Trp He Leu He He 1490 1495 1500

Gin Leu Met Lye Aβp Ser Lye Gly He Phe Glu Lys Asp Trp Gly Glu 1505 1510 1515 1520 Gly Tyr He Thr Aβp Hiβ Met Phe He Asn Leu Asn Val Phe Phe Asn 1525 1530 1535

Ala Tyr Lys Thr Tyr Leu Leu Cys Phe His Lys Gly Tyr Gly Lys Ala 1540 1545 1550

Lys Leu Glu Cys Asp Met Asn Thr Ser Asp Leu Leu Cys Val Leu Glu 1555 1560 1565

Leu He Asp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580

Gin Lys Val He Lys Tyr He He Asn Gin Aβp Thr Ser Leu Hiβ Arg 1585 1590 1595 1600

He Lye Gly Cyβ Hiβ Ser Phe Lys Leu Trp Phe Leu Lys Arg Leu Aβn 1605 1610 1615

Aβn Ala Lye Phe Thr Val Cys Pro Trp Val Val Asn He Asp Tyr His 1620 1625 1630

Pro Thr His Met Lys Ala He Leu Ser Tyr He Aβp Leu Val Arg Met 1635 1640 1645

Gly Leu He Asn Val Asp Lys Leu Thr He Lys Asn Lys Asn Lys Phe 1650 1655 1660

Asn Asp Glu Phe Tyr Thr Ser Aβn Leu Phe Tyr He Ser Tyr Aβn Phe 1665 1670 1675 1680

Ser Aβp Asn Thr Hiβ Leu Leu Thr Lye Gin He Arg He Ala Aen Ser 1685 1690 1695

Glu Leu Glu Aβn Aβn Tyr Asn Lys Leu Tyr His Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Asn Met Ser Leu He Pro Val Lye Ser Aβn Aβn Ser Aβn Lye 1715 1720 1725

Pro Lye Phe Gly He Ser Gly Aβn Thr Glu Ser Met Met Thr Ser Thr 1730 1735 1740

Phe Ser Aβn Lys Thr His He Lys Ser Ser Ala Val He Thr Arg Phe 1745 1750 1755 1760

Asn Tyr Ser Lys Gin Asp Leu Tyr Asn Leu Phe Pro He Val Val He 1765 1770 1775

Asp Arg He He Asp His Ser Gly Asn Thr Ala Lys Ser Asn Gin Leu 1780 1785 1790 Tyr Thr Thr Thr Ser His Gin Thr Ser Leu Val Arg Asn Ser Ala Ser 1795 1800 1805

Leu Tyr Cys Met Leu Pro Trp His His Val Asn Arg Phe Aβn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cys Lys He Ser He Glu Tyr He Leu Lys Aβp 1825 1830 1835 1840

Leu Lye He Lys Asp Pro Ser Cys He Ala Phe He Gly Glu Gly Ala 1845 1850 1855

Gly Asn Leu Leu Leu Arg Thr Val Val Glu Leu His Pro Asp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lye Aβp Cyβ Aβn Aβp Hiβ Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Aβn Gly His He Asn He Asp Tyr Gly Glu 1890 1895 1900

Aβn Leu Thr He Pro Ala Thr Aβp Ala Thr Aβn Asn He His Trp Ser 1905 1910 1915 1920

Tyr Leu Hiβ He Lye Phe Ala Glu Pro He Ser He Phe Val Cys Asp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Asn Trp Ser Lys He He He Glu Trp 1940 1945 1950

Ser Lys His Val Arg Lys Cys Lys Tyr Cys Ser Ser Val Asn Arg Cyβ 1955 1960 1965

He Leu He Ala Lye Tyr Hiβ Ala Gin Asp Aβp He Aβp Phe Lye Leu 1970 1975 1980

Aep Aβn He Thr He Leu Lye Thr Tyr Val Cye Leu Gly Ser Lye Leu 1985 1990 1995 2000

Lys Gly Ser Glu Val Tyr Leu Val Leu Thr He Gly Pro Ala Aβn He 2005 2010 2015

Leu Pro Val Phe Asn Val Val Gin Asn Ala Lys Leu He Leu Ser Arg 2020 2025 2030

Thr Lye Asn Phe He Met Pro Lys Lys Thr Asp Lys Glu Ser He Asp 2035 2040 2045

Ala Aβn He Lys Ser Leu He Pro Phe Leu Cys Tyr Pro He Thr Lys 2050 2055 2060

Lys Gly He Lys Thr Ser Leu Ser Lys Leu Lys Ser Val Val Ser Gly 2065 2070 2075 2080

Asp He Leu Ser Tyr Ser He Ala Gly Arg Asn Glu Val Phe Ser Asn 2085 2090 2095

Lys Leu He Asn His Lys Hiβ Met Asn He Leu Lys Trp Leu Asp His 2100 2105 2110

Val Leu Asn Phe Arg Ser Ala Glu Leu Asn Tyr Asn His Leu Tyr Met 2115 2120 2125

He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Aβn Ser Leu Thr 2130 2135 2140

Thr Aβn Glu Leu Lye Lye Leu He Lye He Thr Gly Ser Val Leu Tyr 2145 2150 2155 2160 2165

(2) INFORMATION FOR SEQ ID NO:27:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15219 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 27:

ACGGGAAAAA AATGCGTACT ACAAACTTGC ACATTCGAAA AAAATGGGGC AAATAAGAAC 60

TTGATAAGTG CTATTTAAGT CTAACCTTTT CAATCAGAAA TGGGGTGCAA TTCACTGAGC 120

ATGATAAAGG TTAGATTACA AAATTTATTT GACAATGACG AAGTAGCATT GTTAAAAATA 180

ACATGTTATA CTGATAAATT AATTCTTCTG ACCAATGCAT TAGCCAAAGC AGCAATACAT 240

ACAATTAAAT TAAACGGCAT AGTTTTTATA CATGTTATAA GAAGCAGTGA AGTGTGCCCT 300

GATAACAATA TTGTAGTGAA ATCTAACTTT ACAACAATGC CAATACTACA AAATGGAGGA 360

TACATATGGG AATTGATTGA GTTGACACAC TGCTCTCAAT TAAACGGTTT AATGGATGAT 420

AATTGTGAAA TCAAATTTTC TAAAAGACTA AGTGACTCAG TAATGACTAA TTATATGAAT 480

CAAATATCTG ACTTACTTGG GCTTGATCTC AATTCATGAA TTATGTTTAG TCTAATTCAA 540 TAGACATGTG TTTATTACCA TTTTAGTTAA TATAAAAACT CATCAAAGGG AAATGGGGCA 600

AATAAACTCA CCTAATCAAT CAAACCATGA GCACTACAAA TGACAACACT ACTATGCAAA 660

GATTGATGAT CACAGACATG AGACCCCTGT CAATGGATTC AATAATAACA TCTCTTACCA 720

AAGAAATCAT CACACACAAA TTCATATACT TGATAAACAA TGAATGTATT GTAAGAAAAC 780

TTGATGAAAG ACAAGCTACA TTTACATTCT TAGTCAATTA TGAGATGAAG CTACTGCACA 840

AAGTAGGGAG TACCAAATAC AAAAAATACA CTGAATATAA TACAAAATAT GGCACTTTCC 900

CCATGCCTAT ATTTATGAAT CACGGCGGGT TTCTAGAATG TATTGGCATT AAGCCTACAA 960

AACAGACTCC TATAATATAC AAATATGACC TCAACCCGTG AATTCCAACA AAAAAACCAA 1020

CCCAACCAAA CCAAACTATT CCTCAAACAA CAGTGCTCAA TAGTTAAGAA GGAGCTAATC 1080

CATTTTAGTA ATTAAAAATA AAAGTAAAGC CAATAACATA AATTGGGGCA AATACAAAGA 1140

TGGCTCTTAG CAAAGTCAAG TTGAATGATA CATTAAATAA GGATCAGCTG CTGTCATCCA 1200

GCAAATACAC TATTCAACGT AGTACAGGAG ATAATATTGA CACTCCCAAT TATGATGTGC 1260

AAAAACACCT AAACAAACTA TGTGGTATGC TATTAATCAC TGAAGATGCA AATCATAAAT 1320

TCACAGGATT AATAGGTATG TTATATGCTA TGTCCAGGTT AGGAAGGGAA GACACTATAA 1380

AGATACTTAA AGATGCTGGA TATCATGTTA AAGCTAATGG AGTAGATATA ACAACATATC 1440

GTCAAGATAT AAATGGAAAG GAAATGAAAT TCGAAGTATT AACATTATCA AGCTTGACAT 1500

GAGAAATACA AGTCAATATT GAGATAGAAT CTAGAAAGTC CTACAAAAAA ATGCTAAAAG 1560

AGATGGGAGA AGTGGCTCCA GAATATAGGC ATGATTCTCC AGACTGTGGG ATGATAATAC 1620

TGTGTATAGC TGCACTTGTG ATAACCAAAT TAGCAGCAGG AGACAGATCA GGTCTTACAG 1680

CAGTAATTAG GAGGGCAAAC AATGTCTTAA AAAACGAAAT AAAACGATAC AAGGGCCTCA 1740

TACCAAAGGA TATAGCTAAC AGTTTTTATG AAGTGTTTGA AAAACACCCT CATCTTATAG 1800

ATGTTTTCGT GCACTTTGGC ATTGCACAAT CATCCACAAG AGGGGGTAGT AGAGTTGAAG 1860

GAATCTTTGC AGGATTGTTT ATGAATGCCT ATGGTTCAGG GCAAGTAATG CTAAGATGGG 1920

GAGTTTTAGC CAAATCTGTA AAAAATATCA TGCTAGGACA TGCTAGTGTC CAGGCAGAAA 1980

TGGAGCAAGT TGTGGAAGTC TATGAGTATG CACAGAAGTT GGGAGGAGAA GCTGGATTCT 2040

ACCATATATT GAACAATCCA AAAGCATCAT TGCTGTCATT AACTCAATTT CCCAACTTCT 2100 CAAGTGTGGT CCTAGGCAAT GCAGCAGGTC TAGGCATAAT GGGAGAGTAT AGAGGTACAC 2160

CAAGAAACCA GGATCTTTAT GATGCAGCTA AAGCATATGC AGAGCAACTC AAAGAAAATG 2220

GAGTAATAAA CTAGAGTGTA TTAGACTTAA CAGCAGAAGA ATTGGAAGCC ATAAAGCATC 2280

AACTCAACCC CAAAGAAGAT GATGTAGAGC TTTAAGTTAA CAAAAAATAC GGGGCAAATA 2340

AGTCAACATG GAGAAGTTTG CACCTGAATT TCATGGAGAA GATGCAAATA ACAAAGCTAC 2400

CAAATTCCTA GAATCAATAA AGGGCAAGTT CGCATCATCC AAAGATCCTA AGAAGAAAGA 2460

TAGCATAATA TCTGTTAACT CAATAGATAT AGAAGTAACT AAAGAGAGCC CGATAACATC 2520

TGGCACCAAC ATCATCAATC CAACAAGTGA AGCCGACAGT ACCCCAGAAA CAAAAGCCAA 2580

CTACCCAAGA AAACCCCTAG TAAGCTTCAA AGAAGATCTC ACCCCAAGTG ACAACCCTTT 2640

TTCTAAGTTG TACAAGGAAA CAATAGAAAC ATTTGATAAC AATGAAGAAG AATCTAGCTA 2700

CTCATATGAA GAGATAAATG ATCAAAGAAA TGACAACATT ACAGCAAGAC TAGATAGAAT 2760

TGATGAAAAA TTAAGTGAAA TATTAGGAAT GCTCCATACA TTAGTAGTTG CAAGTGCAGG 2820

ACCCACTTCA GCTCGCGATG GAATAAGAGA TGCTATGGTT GGTCTAAGAG AAGAGATGAT 2880

AGAAAAAATA AGAGCGGAAG CATTAATGAC CAATGATAGG TTAGAGGCTA TGGCAAGACT 2 40

TAGGAATGAG GAAAGCGAAA AAATGGCAAA AGACACCTGA GATGAAGTGT CTCTTAATCC 3000

AACTTCCAAA AAATTGAGTG ACTTGTTGGA AGACAACGAT AGTGACAATG ATCTATCACT 3060

TGATGATTTT TGATCAGCGA TCAACTCACT CAGCAATCAA CAACATCAAT AAAAGAGACA 3120

TCAATCCATT GAATCAACTG CCAGACCGAA CAAACAAACG TCCATCAGTA GAACCACCAA 3180

CCAATCAATC AACCAATTGA TCAATCAGCA ACCCGACAAA ATTAACAATA TAGTAACAAA 3240

AAAAGAACAA GATGGGGCAA ATATGGAAAC ATACGTGAAC AAGCTTCACG AAGGCTCCAC 3300

ATACACAGCA GCTGTTCAGT ACAATGTTCT AGAAAAAGAT GATGATCCTG CATCACTAAC 3360

AATATGGGTG CCTATGTTCC AGTCATCTGT GCCAGCAGAC TTGCTCATAA AAGAACTTGC 3420

AAGCATGAAT ATACTAGTGA AGCAGATCTC TACGCCCAAA GGACCTTCAC TACGAGTCAC 3480

GATTAACTCA AGAAGTGCTG TGCTGGCTCA AATGCCTAGT AATTTCATCA TAAGCGCAAA 3540

TGTATCATTA GATGAAAGAA GCAAATTAGC ATATGATGTA ACTACACCTT GTGAAATCAA 3600

AGCATGCAGT CTAACATGCT TAAAAGTAAA AAGTATGTTA ACTACAGTCA AAGATCTTAC 3660 CATGAAGACA TTCAACCCCA CTCATGAGAT CATTGCTCTA TGTGAATTTG AAAATATTAT 3 20

GACATCAAAA AGAGTAATAA TACCAACCTA TCTAAGATCA ATTAGTGTCA AGAACAAGGA 3780

TCTGAACTCA CTAGAAAATA TAGCAACCAC CGAATTCAAA AATGCTATCA CCAATGCAAA 3840

AATTATTCCT TATGCAGGAT TAGTGTTAGT TATCACAGTT ACTGACAATA AAGGAGCATT 3900

CAAATATATC AAACCACAGA GTCAATTTAT AGTAGATCTT GGTGCCTACC TAGAAAAAGA 3960

GAGCATATAT TATGTGACTA CTAATTGGAA GCATACAGCT ACACGTTTTT CAATCAAACC 4020

ACTAGAGGAT TAAACTTAAT TATCAACACT GAATGACAGG TCCACATATA TCCTCAAACT 4080

ACACACTATA TCCAAACATC ATAAACATCT ACACTACACA CTTCATCACA CAAACCAATC 4140

CCACTCAAAA TCCAAAATCA CTACCAGCCA CTATCCGCTA GACCTAGAGT GCGAATAGGC 4200

AAATAAAACC AAAATATGGG GTAAATAGAC ATTAGTTAGA GTTCAATCAA TCTTAACAAC 4260

CATTTATACC GCCAATTCAA CACATATACT ATAAATCTTA AAATGGGAAA TACATCCATC 4320

ACAATAGAAC TCACAAGCAA ATTTTGGCCC TATTTTACAC TAATACATAT GATCTTAACT 4380

CTAATCTTTT TACTAATTAT AATCACTATC ATGATTGCAA CACTAAATAA GCTAAGTGAA 4440

CACAAAGCAT TCTGCAACAA AACTCTTGAA CTAGGACAGA TGTACGAAAT CAACACAGAG 4500

AGTTCCACCA TTATGCTGTG TCAAACCATA ATCCTGTATA TACAAACAAA CAAATCCAAT 4560

CCTCTCACAG AGTCACGGTG TCGCAAAACC ACGCTAACCA TCATGGTAGC ATAGAGTAGT 4620

TATTTAAAAA TTAACATAAT GATGAATTGT TAGTATGAGA TCAAAAACAA CATTGGGGCA 4680

AATGCAACCA TGTCCAAACA CAAGAATCAA CGCACTGCCA GGACTCTAGA AAAGACCTGG 4740

GATACTCTTA ATCATCTAAT TGTAATATCC TCTTGTTTAT ACAGATTAAA TTTAAAATCT 4800

ATAGCACAAA TAGCACTATC AGTTTTGGCA ATGATAATCT CAACCTCTCT CATAATTGCA 4860

GCCATAATAT TCATCATCTC TGCCAATCAC AAAGTTACAC TAACAACGGT CACAGTTCAA 4920

ACAATAAAAA ACCACACTGA AAAAAACATC ACCACCTACC CTACTCAAGT CTCACCAGAA 4980

AGGGTTAGTT CATCCAAGCA ACCCACAACC ACATCACCAA TCGACACAAG TTCAGCTACA 5040

ACATCACCCA ATACAAAATC AGAAACACAC CATACAAGAG CACAAACCAA AGGCAGAACC 5100

ACCACTTCAA CACAGACCAA CAAGCCAAGC ACAAAACCAC GTCCAAAAAA TCCACCAAAA 5160

AAAGATGATT ACCATTTTGA AGTGTTCAAC TTCGTTCCCT GCAGTATATG TGGCAACAAT 5220 CAACTTTGCA AATCCATCTG CAAAACAATA CCAAGCAACA AACCAAAGAA GAAACGAACC 5 80

ATCAAACCCA CAAACAAACC AACCACCAAA ACCACAAACA AAAGAGACCC AAAAACACCA 5340

GCCAAAACGA CGAAAAAAGA AACTACCACC AACCCAACAA AAAAACTAAC CCTGAAGACC 5400

ACAGAAAGAG ACACCAGCAC CTCACAATCC ACTGCACTCG ACACAACCAC ATTAAAACAC 5460

ACAGTCCAAC AGCAATCCCT CCTCTCAACC ACCCCCGAAA ACACACCCAA CTCCACACAA 5520

ACACCCACAG CATCCGAGCC CTCCACACCA AACTCCACCC AAAAAACCCA GCCACATGCT 5580

TAGTTATTCA AAAACTACAT CTTAGCAGAG AACCGTGATC TATCAAGCAA GAACGAAATT 5640

AAACCTGGGG CAAATAACCA TGGAGTTGAT GATCCACAAG TGAAGTGCAA TCTTCCTAAC 5700

TCTTGCTATT AATGCATTGT ACCTCACCTC AAGTCAGAAC ATAACTGAGG AGTTTTACCA 5760

ATCGACATGT AGTGCAGTTA GCAGAGGTTA TTTTAGTGCT TTAAGAACAG GTTGGTATAC 5820

TAGTGTCATA ACAATAGAAT TAAGTAATAT AAAAGAAACC AAATGCAATG GAACTGACAC 5880

TAAAGTAAAA CTTATGAAAC AAGAATTAGA TAAGTATAAG AATGCAGTAA CAGAATTACA 5940

GCTACTTATG CAAAACACAC CAGCTGTCAA CAACCGGGCC AGAAGAGAAG CACCACAGTA 6000

TATGAACTAC ACAATCAATA CCACTAAAAA CCTAAATGTA TCAATAAGCA AGAAGAGGAA 6060

ACGAAGATTT CTAGGCTTCT TGTTAGGTGT GGGATCTGCA ATAGCAAGTG GTATAGCTGT 6120

ATCAAAAGTT CTACACCTTG AAGGAGAAGT GAACAAGATC AAAAATGCTT TGTTGTCTAC 6180

AAACAAAGCT GTAGTCAGTT TATCAAATGG GGTCAGTGTT TTAACCAGCA AAGTGTTAGA 6240

TCTCAAGAAT TACATAAATA ACCAATTATT ACCCATAGTA AATCAACAGA GCTGTCGCAT 6300

CTCCAACATT GAAACAGTTA TAGAATTCCA GCAGAAGAAC AGCAGATTGT TGGAAATCAC 6360

CAGAGAATTT AGTGTCAATG CAGGTGTAAC AACACCTTTA AGCACTTACA TGTTGACAAA 6420

CAGTGAGTTA CTATCATTAA TCAATGATAT GCCTATAACA AATGATCAGA AAAAATTAAT 6480

GTCAAGCAAT GTTCAGATAG TAAGGCAACA AAGTTATTCC ATCATGTCTA TAATAAAGGA 6540

AGAAGTCCTT GCATATGTTG TACAGCTGCC TATCTATGGT GTAATAGATA CACCTTGCTC! 6600

GAAATTGCAC ACATCGCCTC TATGCACTAC CAACATCAAA GAAGGATCAA ATATTTGTTT 6660

AACAAGGACT GATAGAGGAT GGTATTGTGA TAATGCAGGA TCAGTATCCT TCTTTCCACA 6720

GGCTGACACT TGTAAAGTAC AGTCCAATCG AGTATTTTGT GAGACTATGA ACAGTTTGAO 6780 ATTACCAAGT GAAGTCAGCC TTTGTAACAC TGACATATTC AATTCCAAGT ATGACTGCAA 6840

AATTATGACA TCAAAAACAG AGATAAGCAG CTCAGTAATT ACTTCTCTTG GAGCTATAGT 6900

GTCATGCTAT GGTAAAACTA AATGCACTGC ATCCAACAAA AATCGTGGGA TTATAAAGAC 6960

ATTTTCTAAT GGTTGTGACT ATGTGTCAAA CAAAGGAGTA GATACTCTGT CAGTGGGCAA 7020

CACTTTATAC TATGTAAACA AGCTGGAAGG CAAGAACCTT TATGTAAAAG GGGAACCTAT 7080

AATAAATTAC TATGACCCTC TAGTGTTTCC TTCTGATGAG TTTGATGCAT CAATATCTCA 7140

AGTCAATGAA AAAATCAATC AAAGTTTAGC TTTTATTCGT AGATCTGATG AATTACTACA 7200

TAATGTAAAT ACTGGCAAAT CTACTACAAA TATTATGATA ACTACAATTA TTATAGTAAT 7260

CATTGTAGTA TTGTTATCAT TAATAGCTAT TGGTTTACTG TTGTATTGTA AAGCCAAAAA 7320

CACACCAGTT ACACTAAGCA AAGACCAACT AAGTGGAATC AATAATATTG CATTCAGCAA 7380

ATAGACAAAA AACCACCTGA TCATGTTTCA ACAACAATCT GCTGACCACC AATCCCAAAT 7440

CAACTTACAA CAAATATTTC AACATCACAG TACAGGCTGA ATCATTTCCT CACATCATGC 7500

TACCCACATA ACTAAGCTAG ATCCTTAACT TATAGTTACA TAAAAACCTC AAGTATCACA 7560

ATCAACGACT AAATCAACAC ATCATTGACA AAATTAACAG CTGGGGCAAA TATGTCGCGA 7620

AGAAATCCTT GTAAATTTGA GATTAGAGGT CATTGCTTGA ATGGTAGAAG ATGTCACTAC 7680

AGTCATAATT ACTTTGAATG GCCTCCTCAT GCATTACTAG TGAGGCAAAA CTTCATGTTA 7740

AACAAGATAC TCAAGTCAAT GGACAAAAGC ATAGACACTT TGTCTGAAAT AAGTGGAGCT 7800

GCTGAACTGG ATAGAACAGA AGAATATGCT CTTGGTATAG TTGGAGTGCT AGAGAGTTAC 7860

ATAGGATCTA TAAAGAAGAT AACAAAACAA TGAGCATGTG TTGCTATGAG TAAACTTCTT 7920

ATTGAGATCA ATAGTGATGA CATTAAAAAG CTTAGAGATA ATGAAGAACC CAATTGACCT 7980

AAGATAAGAG TGTACAATAC TGTTATATCA TACATTGAGA GCAATAGAAA AAACAACAAG 8040

CAAACCATCC ATCTGCTCAA GAGACTACCA GCAGACGTGC TGAAGAAGAC AATAAAGAAC 8100

ACATTAGATA TCCACAAAAG CATAACCATA AGGAATCCAA AAGAGTCAAC TGTGAATGAT 8160

CAAAATGACC AAACCAAAAA TAATGATATT ACCGGATAAA TATCCTTGTA GTATATCATC 8220

CATATTGATC TCAAGTGAAA GCATGGTTGC TACATTCAAT CATAAAAACA TATTACAATT 8280

TAACCATAAC TATTTGGATA ACCACCAGCG TTTATTAAAT GATATATTTG ATGAAATTCA 8340 TTGGACACCT AAAAACTTAT TAGATGCCAC TCAACAATTT CTCGAACATC TTAACATCCC 8400

TGAAGATATA TATACAGTAT ATATATTAGT GTCATAATGC TTGACCATAA CGACTCTATG 8460

TCATCCAACC ATAAAACTAT TTTGATAAGG TTATGGGACA AAATGGATCC CATTATTAAT 8520

GGAAACTCTG CTAATGTGTA TCTAACTGAT AGTTATTTAA AAGGTGTTAT CTCTTTTTCA 8580

GAGTGTAATG CTTTAGGGAG TTATCTTTTT AACGGCCCTT ATCTTAAAAA TGATTACACC 8640

AACTTAATTA GTAGACAAAG CCCACTACTA GAGCATATGA ATCTTAAAAA ACTAACTATA 8700

ACACAGTCAT TAATATCTAG ATATCATAAA GGTGAACTGA AATTAGAAGA ACCAACTTAT 8760

TTCCAGTCAT TACTTATGAC ATATAAAAGT ATGTCCTCGT CTGAACAAAT TGCTACAACT 8820

AACTTACTTA AAAAAATAAT ACGAAGAGCC ATAGAAATAA GTGATGTAAA GGTGTACGCC 8880

ATCTTGAATA AACTAGGATT AAAGGAAAAG GACAGAGTTA AGCCCAACAA TAATTCAGGT 8940

GATGAAAACT CAGTACTTAC AACCATAATT AAAGATGATA TACTTTCGGC TGTGGAAAAC 9000

AATCAATCAT ATACAAATTC AGACAAAAGT CACTCAGTAA ATCAAAATAT CACTATCAAA 9060

ACAACACTCT TGAAAAAATT GATGTGTTCA ATGCAACATC CTCCATCATG GTTAATACAC 9120

TGGTTCAATT TATATACAAA ATTAAATAAC ATATTAACAC AATATCGATC AAATGAGGTA 9180

AAAAGTCATG GGTTTATATT AATAGATAAT CAAACTTTAA GTGGTTTTCA GTTTATTTTA 9240

AATCAATATG GTTGTATCGT TTATCATAAA GGACTCAAAA AAATCAGAAC TACTACTTAC 9300

AATCAATTTT TGACATGGAA AGACATCAGC CTTAGCAGAT TAAATGTTTG CTTAATTACT 9360

TGGATAAGTA ATTCTTTAAA TACATTAAAC AAAAGCTTAG GGCTGAGATG TGGATTCAAT 9420

AATGTTGTGT TATCACAATT ATTTCTTTAT GGAGATTGTA TACTGAAATT ATTTCATAAT 9480

GAAGGCTTCT ACATAATAAA AGAAGTAGAG GGATTTATTA TGTCTTTAAT TCTAAACATA 9540

ACAGAAGAAG ATCAATTTAA GAAACGATTT TATAATAGCA TGCTAAATAA CATCACAGAT 9600

GCAGCTATTA AGGCTCAAAA GGACCTACTA TCAAGAGTAT GTCACACTTT ATTAGACAAG 9660

ACAGTGTCTG ATAATATCAT AAATGG AAA TGGATAATCC TATTAAGTAA ATTTCTTAAA 9720

TTGATTAAGC TTGCAGGTCA TAATAATCTC AATAACTTGA GTCAGCTATA TTTTCTCTTC 9780

AGAATCTTTG GACATCCAAT GGTCGATGAA AGACAAGCAA TGGATTCTGT AAGAATTAAC 9840

TGTAATGAAA CTAGGTTCTA CTTATTAAGT AGTCTAAGTA CATTAAGAGG TGCTTTCATT 9900 TATAGAATCA TAAAAGGGTT TGTAAATACC TACAACAGAT GGCCCACCTT AAGGAATGCT 9960

ATTGTCCTAC CTCTAAGATG GTTAAACTAC TATAAACTTA ATACTTATCC ATCTCTACTT 10020

GAAATCACAG AAAATGATTT GATTATTTTA TCAGGATTGC GGTTCTATCG TGAGTTTCAT 10080

CTGCCTAAAA AAGTGGATCT TGAAATGATA ATAAATGACA AAGCCATTTC ACCTCCAAAA 10140

GATCTAATAT GGACTAGTTT TCCTAGAAAT TACATGCCAT CACATATACA AAATTATATA 10200

GAACATGAAA AGTTGAAGTT CTCTGAAAGC GACAGATCGA GAAGAGTACT AGAGTATTAC 10260

TTGAGAGATA ATAAATTCAA TGAATGCGAT CTATACAATT GTGTAGTCAA TCAAAGCTAT 10320

CTCAACAACT CTAATCACGT GGTATCACTA ACTGGTAAAG AAAGAGAGCT CAGTGTAGGT 10380

AGAATGTTTG CTATGCAACC AGGTATGTTT AGGCAAATCC AAATCTTAGC AGAGAAAATG 10440

ATAGCTGAAA ATATTTTACA ATTCTTCCCT GAGAGTTTGA CAAGATATGG TGATCTAGAG 10500

CTTCAAAAGA TATTAGAATT AAAAGCAGGA ATAAGCAAGA AGTCAAATCG TTATAATGAT 10560

AACTACAACA ATTATATCAG TAAATGTTCT ATCATTACAG ATCTTAGCAA ATTCAATCAG 10620

GCATTTAGAT ATGAAACATC ATGTATCTGC AGTGATGTAT TAGATGAACT GCATGGAGTA 10680

CAATCTCTGT TCTCTTGGTT GCATTTAACA ATACCTCTTG TCACAATAAT ATGTACATAT 10740

AGACATGCAC CTCCTTTCAT AAAGGATCAT GTTGTTAATC TTAATGAGGT TGATGAACAA 10800

AGTGGATTAT ACAGATATCA TATGGGTGGT ATTGAGCGCT GGTGTCAAAA ACTGTGGACC 10860

ATTGAAGCTA TATCATTATT AGATCTAATA TCTCTCAAAG GGAAATTCTC TATCACAGCT 10920

CTGATAAATG GTGATAATCA GTCAATTGAT ATAAGCAAAC CAGTTAGACT TATAGAGGGT 10980

CAGACCCATG CACAAGCAGA TTATTTGTTA GCATTAAATA GCCTTAAATT GTTATATAAA 11040

GAGTATGCAG GTATAGGCCA TAAGCTTAAG GGAACAGAGA CCTATATATC CCGAGATATG 11100

CAGTTCATGA GCAAAACAAT CCAGCACAAT GGAGTGTACT ATCCAGCCAG TATCAAAAAA 11160

GTCCTGAGAG TAGGTCCATG GATAAACACG ATACTTGATG ATTTTAAAGT TAGTTTAGAA 11220

TCTATAGGCA GCTTAACACA GGAGTTAGAA TACAGAGGAG AAAGCTTATT ATGCAGTTTA 11280

ATATTTAGGA ACATTTGGTT ATACAATCAA ATTGCTTTGC AACTCCGAAA TCATGCATTA 11340

TGTAACAATA AGCTATATTT AGATATATTG AAAGTATTAA AACACTTAAA AACTTTTTTT 11400

AATCTTGATA GCATTGATAT GGCTTTATCA TTGTATATGA ATTTGCCTAT GCTGTTTGGT 11460 GGTGGTGATC CTAATTTGTT ATATCGAAGC TTTTATAOGA GAAGCTATAG TACATTCAGT GTTTGTGTTG AGCTATTATA

AAGCTCCAGG ATCTTCCAGA TGATAGACTG AAGAAATTCT GATAAAAATC CCAATGCCGA GTTTGTAACA TTGATCAGGG GAAAGGCAAG CTAAAATTAC TAGTGAGATT AATAGATTAG ATAGCCCCAA ACAAAATATT TTCTAAAAGT GCACAACATT CTAAATGACA TTATGCAAAA TATAGAACCA ACTTACCCTC

GAAAGTTTAC CTTTTTATAA AGCAGAAAAA ATAGTTAATC ATAACTAATA TACTTGAAAA AACATCAGCA ATAGATACAA GATATCATGA GGAAAAATAT AACTTTACTT ATAAGGATAC GACAAAAGAG AGTTATTAAG TTTAGAAAAT CTTAGTATAA AGAGAAAGAT CTTGGTCATT ATCCAATATA GTAGGAGTAA ACAATGAACA TTAAATATAC AACTAGCACT ATAGCCAGTG AATGTTAATA GTTTAACTCG TGGTGAAAGA GGACCGACCA ACGCAGGAGA AAAAAACAAT GCCAGTGTAC AACAGACAAG

GACCAAATAG ATTTATTAGC AAAATTAGAC TGGGTATATG GAATTCATGG AAGAACTGAG TACTGGAACA CTTGGACTGT TTGTTTCCAC AATATCTAAG TGTCAATTAT TTACACCGTT TGTGAATTCC CTGCATCAAT ACCAGCTTAT AGAACAACAA CCTATCAATC ATGTATTAAC AGAAAAGTAT GGAGATGAAG AATTGCATAA GTTTTGGTCT TAGCCTGATG TCGGTTGTGG CCTAATAGAA TTATTCTCAT ACCGAAGCTG AATGAGATAC TTTACAGGAG ATGTTGATAT CATCAAGTTG AAGCAAGTGA

CTACCAGATA AAATAAGTTT AACCCAATAT GTAGAATTAT AAATCTGGAT CTCACATCAA CTCTAATTTA ATATTAGTAC CATAATGCTT ATATTTTAAG TACTAATTTA GCTGGACATT ATCAAAGATT CAAAAGGTAT TTTTGAAAAA GATTGGGGAG AGGGGTACAT AACTGATCAT 13080

ATGTTCATTA ATTTGAATGT TTTCTTTAAT GCTTATAAGA CTTATTTGCT ATGTTTTCAT 13140

AAAGGTTATG GTAAAGCAAA ATTAGAATGT GATATGAACA CTTCAGATCT TCTTTGTGTT 13200

TTGGAGTTAA TAGACAGTAG CTACTGGAAA TCTATGTCTA AAGTTTTCCT AGAACAAAAA 13260

GTCATAAAAT ACATAGTCAA TCAAGACACA AGTTTGCGTA GAATAAAAGG CTGTCACAGT 13320

TTTAAGTTGT GGTTTTTAAA ACGCCTTAAT AATGCTAAAT TTACCGTATG CCCTTGGGTT 13380

GTTAACATAG ATTATCACCC AACACACATG AAAGCTATAT TATCTTACAT AGATTTAGTT 13440

AGAATGGGGT TAATAAATGT AGATAAATTA ACCATTAAAA ATAAAAACAA ATTCAATGAT 13500

GAATTTTACA CATCAAATCT CTTTTACATT AGTTATAACT TTTCAGACAA CACTCATTTG 13560

CTAACAAAAC AAATAAGAAT TGCTAATTCA GAATTAGAAG ATAATTATAA CAAACTATAT 13620

CACCCAACCC CAGAAACTTT AGAAAATATG TCATTAATTC CTGTTAAAAG TAATAATAGT 13680

AACAAACCTA AATTTTGTAT AAGTGGAAAT ACCGAATCTA TGATGATGTC AACATTCTCT 13740

AGTAAAATGC ATATTAAATC TTCCACTGTT ACCACAAGAT TCAATTATAG CAAACAAGAC 13800

TTGTACAATT TATTTCCAAT TGTTGTGATA GACAAGATTA TAGATCATTC AGGTAATACA 13860

GCAAAATCTA ACCAACTTTA CACCACCACT TCACATCAGA CATCTTTAGT AAGGAATAGT 13920

GCATCACTTT ATTGCATGCT TCCTTGGCAT CATGTCAATA GATTTAACTT TGTATTTAGT 13980

TCCACAGGAT GCAAGATCAG TATAGAGTAT ATTTTAAAAG ATCTTAAGAT TAAGGACCCC 14040

AGTTGTATAG CATTCATAGG TGAAGGAGCT GGTAACTTAT TATTACGTAC GGTAGTAGAA 14100

CTTGATCCAG ACATAAGATA CATTTACAGA AGTTTAAAAG ATTGCAATGA TCATAGTTTA 14160

CCTATTGAAT TTCTAAGGTT ATACAACGGG CATATAAACA TAGATTATGG TGAGAATTTA 14220

ACCATTCCTG CTACAGATGC AACTAATAAC ATTCATTGGT CTTATTTACA TATAAAATTT 14280

GCAGAACCTA TTAGCATCTT TGTCTGCGAT GCTGAATTAC CTGTTACAGC CAATTGGAGT 14340

AAAATTATAA TTGAATGGAG TAAGCATGTA AGAAAGTGCA AGTACTGTTC TTCTGTAAAT 14400

AGATGCATTT TAATTGCAAA ATATCATGCT CAAGATGACA TTGATTTCAA ATTAGATAAC 14460

ATTACTATAT TAAAAACTTA CGTGTGCCTA GGTAGCAAGT TAAAAGGATC TGAAGTTTAC 14520

TTAATCCTTA CAATAGGCCC TGCAAATATA CTTCCTGTTT TTGATGTTGT ACAAAATGCT 14580 AAATTGATAC TTTCAAGAAC TAAAAATTTC ATTATGCCTA AAAAAACTGA CAAGGAATCT 14640

ATCGATGCAA ATATTAAAAG CTTAATACCT TTCCTTTGTT ACCCTATAAC AAAAAAAGGA 14700

ATTAAGACTT CATTGTCAAA ATTGAAQAGT GTAGTTAATG GAGATATATT ATCATATTCT 14760

ATAGCTGGAC GTAATGAAGT ATTCAGCAAC AAGCTTATAA ACCACAAGCA TATGAATATC 14820

CTAAAATGGC TAGATCATGT TTTAAATTTT AGATCAGCTG AACTTAATTA CAATCATTTA 14880

TACATGATAG AGTCCACATA TCCTTACTTA AGTGAATTGT TAAATAGTTT AACAACCAAT 14940

GAGCTCAAGA AGCTGATTAA AATAACAGGT AGTGTGCTAT ACAACCTTCC CAACGAACAG 15000

TAGTTTAAAA TATCATTAAC AAGTTTGGTC AAATTTAGAT GCTAACACAT CATTATATTA 15060

TAGTTATTAA AGAATATACA AACTTTTCAA TAATTTAGCA TATTGATTCC AAAATTATCA 15120

TTTTAGTCTT AAGGGGTTAA ATAAAAGTCT AAAACTAACA ATTATACATG TGCATTCACA 15180

ACACAACGAG ACATTAGTTT TTGACACTTT TTTTCTCGT 15219 (2) INFORMATION FOR SEQ ID NO: 28:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS :

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 28:

Met Asp Pro He He Asn Gly Asn Ser Ala Asn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lys Gly Val He Ser Phe Ser Glu Cys Asn Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Asn Gly Pro Tyr Leu Lys Aen Aβp Tyr Thr Aen Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu Hiβ Met Asn Leu Lys Lys Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr His Lys Gly Glu Leu Lys 65 70 75 80 Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lye He 100 105 110

He Arg Arg Ala He Glu He Ser Aβp Val Lye Val Tyr Ala He Leu 115 120 125

Asn Lys Leu Gly Leu Lys Glu Lys Asp Arg Val Lys Pro Asn Asn Asn 130 135 140

Ser Gly Asp Glu Asn Ser Val Leu Thr Thr He He Lys Asp Asp He 145 150 155 160

Leu Ser Ala Val Glu Asn Aβn Gin Ser Tyr Thr Aβn Ser Aβp Lys Ser 165 170 175

His Ser Val Asn Gin Asn He Thr He Lys Thr Thr Leu Leu Lys Lye 180 185 190

Leu Met Cyβ Ser Met Gin His Pro Pro Ser Trp Leu He Hiβ Trp Phe 195 200 205

Aβn Leu Tyr Thr Lye Leu Aβn Aβn He Leu Thr Gin Tyr Arg Ser Aβn 210 215 220

Glu Val Lye Ser Hiβ Gly Phe He Leu He Aβp Aβn Gin Thr Leu Ser 225 230 235 240

Gly Phe Gin Phe He Leu Asn Gin Tyr Gly Cys He Val Tyr His Lys 245 250 255

Gly Leu Lys Lys He Thr Thr Thr Thr Tyr Asn Gin Phe Leu Thr Trp 260 265 270

Lys Aβp He Ser Leu Ser Arg Leu Aβn Val Cys Leu He Thr Trp He 275 280 285

Ser Asn Cys Leu Asn Thr Leu Asn Lys Ser Leu Gly Leu Arg Cys Gly 290 295 300

Phe Asn Asn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Asp Cys He 305 310 315 320

Leu Lys Leu Phe Hiβ Aβn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Aβn He Thr Glu Glu Aβp Gin Phe 340 345 350 Lys Lys Arg Phe Tyr Asn Ser Met Leu Asn Asn He Thr Aβp Ala Ala 355 360 365

He Lys Ala Gin Lys Asp Leu Leu Ser Arg Val Cys His Thr Leu Leu 370 375 380

Asp Lys Thr Val Ser Asp Aβn He He Asn Gly Lys Trp He He Leu 385 390 395 400

Leu Ser Lys Phe Leu Lye Leu He Lys Leu Ala Gly Asp Asn Asn Leu 405 410 415

Asn Asn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly Hiβ Pro 420 425 430

Met Val Aβp Glu Arg Gin Ala Met Aβp Ser Val Arg He Asn Cyβ Asn 435 440 445

Glu Thr Arg Phe Tyr Leu Leu Ser Ser Leu Ser Thr Leu Arg Gly Ala 450 455 460

Phe He Tyr Arg He He Lye Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Asn Tyr 485 490 495

Tyr Lys Leu Asn Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Asn Asp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe His Leu ?ro 515 520 525

Lys Lys Val Asp Leu Glu Met He He Asn Asp Lys Ala He Ser Pro 530 535 540

Pro Lys Asp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

His He Gin Asn Tyr He Glu His Glu Lys Leu Lys Phe Ser Glu Ser 565 570 575

Asp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Asp Asn Lys :?he 580 585 590

Asn Glu Cys Asp Leu Tyr Asn Cys Val Val Aβn Gin Ser Tyr Leu Aβn 595 600 605

Aβn Ser Asn His Val Val Ser Leu Thr Gly Lys Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lys Met He Ala Glu Asn He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Asp Leu Glu Leu Gin Lye He Leu Glu 660 665 670

Leu Lye Ala Gly He Ser Aβn Lys Ser Asn Arg Tyr Asn Asp Asn Tyr 675 680 685

Asn Asn Tyr He Ser Lys Cys Ser He He Thr Asp Leu Ser Lys Phe 690 695 700

Asn Gin Ala Phe Arg Tyr Glu Thr Ser Cys He Cys Ser Asp Val Leu 705 710 715 720

Asp Glu Leu His Gly Val Gin Ser Leu Phe Ser Trp Leu Hiβ Leu Thr 725 730 735

He Pro Leu Val Thr He He Cyβ Thr Tyr Arg Hiβ Ala Pro Pro Phe 740 745 750

He Lye Asp His Val Val Asn Leu Asn Glu Val Asp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr Hiβ Met Gly Gly He Glu Gly Trp Cyβ Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Asp Leu He Ser Leu Lys Gly 785 790 795 800

Lys Phe Ser He Thr Ala Leu He Aβn Gly Aβp Aβn Gin Ser He Asp 805 810 815

He Ser Lys Pro Val Arg Leu He Glu Gly Gin Thr His Ala Gin Ala 820 825 830

Asp Tyr Leu Leu Ala Leu Asn Ser Leu Lys Leu Leu Tyr Lys Glu Tyr 835 840 845

Ala Gly He Gly His Lys Leu Lye Gly Thr Glu Thr Tyr He Ser Arg 850 855 860

Aβp Met Gin Phe Met Ser Lye Thr He Gin Hiβ Asn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lys Lys Val Leu Arg Val Gly Pro Trp He Asn Thr 885 890 895

He Leu Aβp Asp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910 Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cys Ser Leu He Phe 915 920 925

Arg Asn He Trp Leu Tyr Asn Gin He Ala Leu Gin Leu Arg Asn His 930 935 940

Ala Leu Cys Asn Asn Lys Leu Tyr Leu Asp He Leu Lys Val Leu Lys 945 950 955 960

Hiβ Leu Lye Thr Phe Phe Aβn Leu Aβp Ser He Aβp Met Ala Leu Ser 965 970 975

Leu Tyr Met Aβn Leu Pro Met Leu Phe Gly Gly Gly Aβp Pro Aβn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Aβp Phe Leu Thr Glu Ala 995 1000 1005

He Val Hiβ Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly Hiβ Asp Leu 1010 1015 1020

Gin Asp Lye Leu Gin Aβp Leu Pro Aβp Asp Arg Leu Asn Lys Phe Leu 1025 1030 1035 1040

Thr Cys Val He Thr Phe Aβp Lye Aβn Pro Aβn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Aβp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lye He 1060 1065 1070

Thr Ser Glu He Aβn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Aβn Lye He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Asn Asp He Met Gin Asn He Glu Pro Thr Tyr Pro His 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lys Ala Glu Lys 1125 1130 113E

He Val Asn Leu He Ser Gly Thr Lys Ser He Thr Asn He Leu Glu 1140 1145 1150

Lys Thr Ser Ala He Asp Thr Thr Asp He Aen Arg Ala Thr Aβp Met 1155 1160 1165

Met Arg Lys Asn He Thr Leu Leu He Arg He Leu Pro Leu Asp Cyβ 1170 1175 1180 Asn Lye Aβp Lye Arg Glu Leu Leu Ser Leu Glu Aβn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lys Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Asn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asn He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Asn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lye Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lye Lye Thr Met Pro Val Tyr Aβn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lye Lye Gin Arg Aβp Gin He Aβp Leu Leu Ala Lys Leu Aβp 1285 1290 1295

Trp Val Tyr Ala Ser He Aβp Aβn Lye Aβp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lye Ala Lye Lys Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Asn Tyr Leu His Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cys Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Asn 1345 1350 1355 1360

Tyr His Phe Asp Thr Ser Pro He Asn Hiβ Val Leu Thr Glu Lye Tyr 1365 1370 1375

Gly Aβp Glu Aβp He Asp He Val Phe Gin Asn Cys He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Asn He Cyβ Pro Aβn 1395 1400 1405

Arg He He Leu He Pro Lye Leu Aβn Glu He Hiβ Leu Met Lye Pro 1410 1415 1420

Pro He Phe Thr Gly Asp Val Asp He He Lye Leu Lys Gin Val He 1425 1430 1435 1440

Gin Lys Gin His Met Phe Leu Pro Asp Lys He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Asn Lys Ala Leu Lys Ser Gly Ser His He 1460 1465 1470

Asn Ser Asn Leu He Leu Val His Lys Met Ser Asp Tyr Phe His Asn 1475 1480 1485

Ala Tyr He Leu Ser Thr Asn Leu Ala Gly His Trp He Leu He He 1490 1495 1500

Gin Leu Met Lys Asp Ser Lys Gly He Phe Glu Lys Asp Trp Gly Glu 1505 1510 1515 1520

Gly Tyr He Thr Asp His Met Phe He Asn Leu Asn Val Phe Phe Aβn 1525 1530 1535

Ala Tyr Lye Thr Tyr Leu Leu Cyβ Phe Hiβ Lys Gly Tyr Gly Lys Ala 1540 1545 1550

Lys Leu Glu Cyβ Aβp Met Aβn Thr Ser Asp Leu Leu Cys Val Leu Glu 1555 1560 1565

Leu He Asp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580

Gin Lys Val He Lye Tyr He Val Aβn Gin Aβp Thr Ser Leu Arg Arg 1585 1590 1595 1600

He Lye Gly Cyβ Hiβ Ser Phe Lye Leu Trp Phe Leu Lye Arg Leu Asn 1605 1610 1615

Asn Ala Lys Phe Thr Val Cys Pro Trp Val Val Asn He Aβp Tyr His 1620 1625 1630

Pro Thr His Met Lys Ala He Leu Ser Tyr He Asp Leu Val Arg Met 1635 1640 1645

Gly Leu He Asn Val Asp Lys Leu Thr He Lys Asn Lys Asn Lys Phe 1650 1655 1660

Asn Aβp Glu Phe Tyr Thr Ser Asn Leu Phe Tyr He Ser Tyr Asn Phe 1665 1670 1675 1680

Ser Asp Asn Thr His Leu Leu Thr Lys Gin He Arg He Ala Asn Ser 1685 1690 1695

Glu Leu Glu Asp Aβn Tyr Asn Lys Leu Tyr Hiβ Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Aβn Met Ser Leu He Pro Val Lye Ser Aβn Aβn Ser Aβn Lye 1715 1720 1725

Pro Lye Phe Cys He Ser Gly Asn Thr Glu Ser Met Met Met Ser Thr 1730 1735 1740 Phe Ser Ser Lys Met Hiβ He Lys Ser Ser Thr Val Thr Thr Arg Phe 1745 1750 1755 1760

Asn Tyr Ser Lys Gin Aβp Leu Tyr Asn Leu Phe Pro He Val Val He 1765 1770 1775

Asp Lys He He Asp His Ser Gly Asn Thr Ala Lys Ser Aβn Gin Leu 1780 1785 1790

Tyr Thr Thr Thr Ser Hiβ Gin Thr Ser Leu Val Arg Aβn Ser Ala Ser 1795 1800 1805

Leu Tyr Cyβ Met Leu Pro Trp His His Val Aβn Arg Phe Aβn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cyβ Lys He Ser He Glu Tyr He Leu Lys Asp 1825 1830 1835 1840

Leu Lys He Lys Asp Pro Ser Cys He Ala Phe He Gly Glu Gly Ala 1845 1850 1855

Gly Asn Leu Leu Leu Arg Thr Val Val Glu Leu His Pro Asp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lys Asp Cys Aβn Aβp His Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Asn Gly His He Asn He Aβp Tyr Gly Glu 1890 1895 1900

Asn Leu Thr He Pro Ala Thr Asp Ala Thr Aβn Aβn He His Trp Ser 1905 1910 1915 1920

Tyr Leu His He Lys Phe Ala Glu Pro He Ser He Phe Val Cys Asp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Asn Trp Ser Lye He He He Glu Trp 1940 1945 1950

Ser Lys His Val Arg Lys Cys Lye Tyr Cyβ Ser Ser Val Asn Arg Cys 1955 1960 1965

He Leu He Ala Lye Tyr His Ala Gin Asp Asp He Asp Phe Lys Leu 1970 1975 1980

Asp Asn He Thr He Leu Lys Thr Tyr Val Cyβ Leu Gly Ser Lye Leu 1985 1990 1995 2000

Lye Gly Ser Glu Val Tyr Leu He Leu Thr He Gly Pro Ala Aβn He 2005 2010 2015 Leu Pro Val Phe Aβp Val Val Gin Aen Ala Lye Leu He Leu Ser Arg 2020 2025 2030

Thr Lye Aβn Phe He Met Pro Lys Lys Thr Asp Lys Glu Ser He Asp 2035 2040 2045

Ala Aβn He Lye Ser Leu He Pro Phe Leu Cys Tyr Pro He Thr Lys 2050 2055 2060

Lye Gly He Lye Thr Ser Leu Ser Lye Leu Lys Ser Val Val Asn Gly 2065 2070 2075 2080

Asp He Leu Ser Tyr Ser He Ala Gly Arg Asn Glu Val Phe Ser Asn 2085 2090 2095

Lys Leu He Asn Hiβ Lys His Met Asn He Leu Lys Trp Leu Aβp Hiβ 2100 2105 2110

Val Leu Aβn Phe Arg Ser Ala Glu Leu Asn Tyr Asn His Leu Tyr Met 2115 2120 2125

He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Asn Ser Leu Thr 2130 2135 2140

Thr Asn Glu Leu Lys Lye Leu He Lye He Thr Gly Ser Val Leu Tyr 2145 2150 2155 2160 2165

(2) INFORMATION FOR SEQ ID NO: 29:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15219 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 29:

ACGGGAAAAA AATGCGTACT ACAAACTTGC ACATTCGAAA AAAATGGGGC AAATAAGAAC 60

TTGATAAGTG CTATTTAAGT CTAACCTTTT CAATCAGAAA TGGGGTGCAA TTCACTGAGC 120

ATGATAAAGG TTAGATTACA AAATTTATTT GACAATGACG AAGTAGCATT GTTAAAAATA 180

ACATGTTATA CTGATAAATT AATTCTTCTG ACCAATGCAT TAGCCAAAGC AGCAATACAT 240 ACAATTAAAT TAAACGGCAT AGTTTTTATA CATGTTATAA CAAGCAGTGA AGTGTGCCCT 300

GATAACAATA TTGTAGTGAA ATCTAACTTT ACAACAATGC CAATACTACA AAATGGAGGA 360

TACATATGGG AATTGATTGA GTTGACACAC TGCTCTCAAT TAAACGGTTT AATGGATGAT 420

AATTGTGAAA TCAAATTTTC TAAAAGACTA AGTGACTCAG TAATGACTAA TTATATGAAT 480

CAAATATCTG ACTTACTTGG GCTTGATCTC AATTCATGAA TTATGTTTAG TCTAATTCAA 540

TAGACATGTG TTTATTACCA TTTTAGTTAA TATAAAAACT CATCAAAGGG AAATGGGGCA 600

AATAAACTCA CCTAATCAAT CAAACCATGA GCACTACAAA TGACAACACT ACTATGCAAA 660

GATTGATGAT CACAGACATG AGACCCCTCT CAATGGATTC AATAATAACA TCTCTTACCA 720

AAGAAATCAT CACACACAAA TTCATATACT TGATAAACAA TGAATGTATT GTAAGAAAAC 780

TTGATGAAAG ACAAGCTACA TTTACATTCT TAGTCAATTA TGAGATGAAG CTACTGCACA 840

AACTAGGGAG TACGAAATAC AAAAAATACA CTGAATATAA TACAAAATAT GGCACTTTCC 900

CCATGCCTAT ATTTATCAAT CACGGCGGGT TTCTAGAATG TATTGGCATT AAGCCTACAA 960

AACACACTCC TATAATATAC AAATATGACC TCAACCCGTG AATTCCAACA AAAAAACCAA 1020

CCCAACCAAA CCAAACTATT CCTCAAACAA CAGTGCTCAA TAGTTAAGAA GGAGCTAATC 1080

CATTTTAGTA ATTAAAAATA AAAGTAAAGC CAATAACATA AATTGGGGCA AATACAAAGA 1140

TCGCTCTTAG CAAAGTCAAG TTGAATCATA CATTAAATAA GGATCAGCTG CTGTCATCCA 1200

GCAAATACAC TATTCAACGT AGTACAGGAG ATAATATTGA CACTCCCAAT TATGATGTGC 1260

AAAAACACCT AAACAAACTA TGTGGTATGC TATTAATCAC TGAAGATGCA AATCATAAAT 1320

TCACAGGATT AATAGGTATG TTATATGCTA TGTCCAGGTT AGGAAGGGAA GACACTATAA 1380

AGATACTTAA AGATGCTGGA TATCATGTTA AAGCTAATGG AGTAGATATA ACAACATATC 1440

GTCAAGATAT AAATGGAAAG GAAATGAAAT TCGAAGTATT AACATTATCA AGCTTGACAT 1500

CAGAAATACA AGTCAATATT GAGATAGAAT CTAGAAAGTC CTACAAAAAA ATGCTAAAAG 1560

AGATGGGAGA AGTGGCTCCA GAATATAGGC ATGATTCTCC AGACTGTGGG ATGATAATAC 1620

TGTGTATAGC TGCACTTGTG ATAACCAAAT TAGCAGCAGG AGACAGATCA GGTCTTACAG 1680

CAGTAATTAG GAGGGCAAAC AATGTCTTAA AAAACGAAAT AAAACGATAC AAGGGCCTCA 1740

TACCAAAGGA TATAGCTAAC AGTTTTTATG AAGTGTTTGA AAAACACCCT CATCTTATAG 1800 ATGTTTTCGT GCACTTTGGC ATTGCACAAT CATCCACAAG AGGGGGTAGT AGAGTTGAAG 1860

GAATCTTTGC AGGATTGTTT ATGAATGCCT ATGGTTCAGG GGAAGTAATG CTAAGATCGG 1920

GAGTTTTAGC CAAATCTGTA AAAAATATCA TGCTAGGACA TGCTAGTGTC CAGGCAGAAA 1980

TGGAGCAAGT TGTGGAAGTC TATGAGTATG CACAGAAGTT GGGAGGAGAA GCTGGATTCT 2040

ACCATATATT GAACAATCCA AAAGCATCAT TGCTGTCATT AACTCAATTT CCCAACTTCT 2100

CAAGTGTGGT CCTAGGCAAT GCAGCAGGTC TAGGCATAAT GGGAGAGTAT AGAGGTACAC 2160

CAAGAAACCA GGATCTTTAT GATGCAGCTA AAGCATATGC AGAGCAACTC AAAGAAAATG 2220

GAGTAATAAA CTACAGTGTA TTAGACTTAA CAGCAGAAGA ATTGGAAGCC ATAAAGCATC 2280

AACTCAACCC CAAAGAAGAT GATGTAGAGC TTTAAGTTAA CAAAAAATAC GGGGCAAATA 2340

AGTCAACATG GAGAAGTTTG CACCTGAATT TCATGGAGAA GATGCAAATA ACAAAGCTAC 2400

CAAATTCCTA GAATCAATAA AGGGCAAGTT CGCATCATCC AAAGATCCTA AGAAGAAAGA 2460

TAGCATAATA TCTGTTAACT CAATAGATAT AGAAGTAACT AAAGAGAGCC CGATAACATC 2520

TGGCACCAAC ATCATCAATC CAACAAGTGA AGCCGACAGT ACCCCAGAAA CAAAAGCCAA 2580

CTACCCAAGA AAACCCCTAG TAAGCTTCAA AGAAGATCTC ACCCCAAGTG ACAACCCTTT 2640

TTCTAAGTTG TACAAGGAAA CAATAGAAAC ATTTGATAAC AATGAAGAAG AATCTAGCTA 2700

CTCATATGAA GAGATAAATG ATCAAACAAA TGACAACATT ACAGCAAGAC TAGATAGAAT 2760

TGATGAAAAA TTAAGTGAAA TATTAGGAAT GCTCCATACA TTAGTAGTTG CAAGTGCAGC 2820

ACCCACTTCA GCTCGCGATG GAATAAGAGA TGCTATGGTT GGTCTAAGAG AAGAGATGAT 2880

AGAAAAAATA AGAGCGGAAG CATTAATGAC CAATGATAGG TTAGAGGCTA TGGCAAGACT 2940

TAGGAATGAG GAAAGCGAAA AAATGGCAAA AGACACCTCA GATGAAGTGT CTCTTAATCC 3000

AACTTCCAAA AAATTGAGTG ACTTGTTGGA AGACAACGAT AGTGACAATG ATCTATCACT 3060

TGATGATTTT TGATCAQCGA TCAACTCACT CAGCAATCAA CAACATCAAT AAAACAGACA 3120

TCAATCCATT GAATCAACTG CCAGACCGAA CAAACAAACG TCGATCAGTA GAACCACCAA 3180

CCAATCAATC AACCAATTGA TCAATCAGCA ACCCGACAAA ATTAACAATA TAGTAACAAA 3240

AAAAGAACAA GATGGGGCAA ATATGGAAAC ATACGTGAAC AAGCTTCACG AAGGCTCCAC 3300

ATACACAGCA GCTGTTCAGT ACAATGTTCT AGAAAAAGAT GATGATCCTG CATCACTAAC 3360 AATATGGGTG CCTATGTTCC AGTCATCTGT GCCAGCAGAC TTGCTCATAA AAGAACTTGC 3420

AAGCATCAAT ATACTAGTGA AGCAGATCTC TACGCCCAAA GGACCTTCAC TACGAGTCAC 3480

GATTAACTCA AGAAGTGCTG TGCTGGCTCA AATGCCTAGT AATTTCATCA TAAGCGCAAA 3540

TGTATCATTA GATGAAAGAA GCAAATTAGC ATATGATGTA ACTACACCTT GTGAAATCAA 3600

AGCATGCAGT CTAACATGCT TAAAAGTAAA AAGTATGTTA ACTACAGTCA AAGATCTTAC 3660

CATGAAGACA TTCAACCCCA CTCATGAGAT CATTGCTCTA TGTGAATTTG AAAATATTAT 3720

GACATCAAAA AGAGTAATAA TACCAACCTA TCTAAGATCA ATTAGTGTCA AGAACAAGGA 3780

TCTGAACTCA CTAGAAAATA TAGCAACCAC CGAATTCAAA AATGCTATCA CCAATGCAAA 3840

AATTATTCCT TATGCAGGAT TAGTGTTAGT TATCACAGTT ACTGACAATA AAGGAGCATT 3900

CAAATATATC AAACCACAGA GTCAATTTAT AGTAGATCTT GGTGCCTACC TAGAAAAAGA 3960

GAGCATATAT TATGTGACTA CTAATTGGAA GCATACAGCT ACACGTTTTT CAATGAAACC 4020

ACTAGAGGAT TAAACTTAAT TATGAAGACT GAATGACAGG TCCACATATA TCCTCAAACT 4080

ACACACTATA TCCAAAGATC ATAAACATCT ACACTACACA CTTCATCACA CAAACCAATC 4140

CCACTCAAAA TCCAAAATCA CTACCAGCCA CTATCTGCTA GACCTAGAGT GCGAATAGGT 4200

AAATAAAACC AAAATATGGG GTAAATAGAC ATTAGTTAGA GTTCAATCAA TCTTAACAAC 4260

CATTTATACC GCCAATTCAA CACATATACT ATAAATCTTA AAATGGGAAA TACATCCATC 4320

ACAATAGAAT TCACAAGCAA ATTTTGGCCC TATTTTACAC TAATACATAT GATCTTAACT 4380

CTAATCTTTT TACTAATTAT AATCACTATT ATGATTGCAA TACTAAATAA GCTAAGTGAA 4440

CATAAAGCAT TCTGTAACAA AACTCTTGAA CTAGGACAGA TGTATCAAAT CAACACATAG 4500

AGTTCTACCA TTATGCTGTG TCAAATTATA ATCCTGTATA TATAAACAAA CAAATCCAAT 4560

CTTCTCACAG AGTCATGGTG TCGCAAAACC ACGCTAACTA TCATGGTAGC ATAGAGTAGT 4620

TATTTAAAAA TTAACATAAT GATGAATTGT TAGTATGAGA TCAAAAACAA CATTGGGGCA 4680

AATGCAACCA TGTCCAAACA CAAGAATCAA CGCACTGCCA GGACTCTAGA AAAGACCTGG 4740

GATACTCTTA ATCATCTAAT TGTAATATCC TCTTGTTTAT ACAGATTAAA TTTAAAATCT 4800

ATAGCACAAA TAGCACTATC AGTTTTGGCA ATGATAATCT CAACCTCTCT CATAATTGCA 4860

GCCATAATAT TCATCATCTC TGCCAATCAC AAAGTTACAC TAACAACGGT CACAGTTCAA 4920 ACAATAAAAA ACCACACTGA AAAAAACATC ACCACCTACC CTACTCAAGT CTGACCAGAA 4980

AGGGTTAGTT CATCCAAGCA ACCCACAACC ACATCACCAA TCCACACAAG TTCAGCTACA 5040

ACATCACCCA ATACAAAATC AGAAACACAC CATACAACAG CACAAACCAA AGGCAGAACC 5100

ACCACTTCAA CACAGACCAA CAAGCCAAGC ACAAAACCAC GTCCAAAAAA TCCACGAAAA 5160

AAAGATGATT ACCATTTTGA AGTGTTCAAC TTCGTTCCCT GGAGTATATG TGGCAACAAT 5220

CAACTTTGCA AATCCATCTG CAAAACAATA CCAAGCAACA AACCAAAGAA GAAACCAACC 5280

ATCAAACCCA CAAACAAACC AACCACCAAA ACCACAAACA AAAGAGACCC AAAAACACCA. 5340

GCGAAAACGA CGAAAAAAGA AACTACCACC AACCCAACAA AAAAACTAAC CCTCAAGACC 5400

ACAGAAAGAG ACACCAGCAC CTCACAATCC ACTGCACTCG ACACAACCAC ATTAAAACAC 5460

ACAGTCCAAC AGCAATCCCT CCTCTCAACC ACCCCCGAAA ACACACCCAA CTCCACACAA 5520

ACACCCACAG CATCCGAGCC CTCCACACCA AACTCCACCC AAAAAACCCA GCCACATGCT 5580

TAGTTATTCA AAAACTACAT CTTAGCAGAG AACCGTGATC TATCAAGCAA GAACGAAATT 5640

AAACCTGGGG CAAATAACCA TGGAGTTGAT GATCCACAAG TCAAGTGCAA TCTTCCTAAC 5700

TCTTGCTATT AATGCATTGT ACCTCACCTC AAGTCAGAAC ATAACTGAGG AGTTTTACCA 5760

ATCGACATQT AGTGCAGTTA GCAGAGGTTA TTTTAGTGCT TTAAGAACAG GTTGGTATAC 5820

TAGTGTCATA ACAATAGAAT TAAGTAATAT AAAAGAAACC AAATGCAATG GAACTGACAC 5880

TAAAGTAAAA CTTATGAAAC AAGAATTAGA TAAGTATAAG AATGCAGTAA CAGAATTACA 5940

GCTACTTATG CAAAACACAC CAGCTGTCAA CAACCGGGCC AGAAGAGAAG CACCACAGTA 6000

TATGAACTAC ACAATCAATA CCACTAAAAA CCTAAATGTA TCAATAAGCA AGAAGAGGAft 6060

ACGAAGATTT CTAGGCTTCT TGTTAGGTGT GGGATCTGCA ATAGCAAGTG GTATAGCTGT 6120

ATGAAAAGTT CTAGACCTTG AAGGAGAAGT GAACAAGATC AAAAATGCTT TGTTGTCTAC 6180

AAACAAAGCT GTAGTCAGTT TATCAAATGG GGTCAGTGTT TTAACCAGCA AAGTGTTAGA 6240

TCTCAAGAAT TACATAAATA ACCAATTATT ACCCATAGTA AATCAACAGA GCTGTCGCAI 6300

CTCCAACATT GAAACAGTTA TAGAATTCCA GCAGAAGAAC AGCAGATTGT TGGAAATCAC 6360

CAGAGAATTT AGTGTCAATG CAGGTG AAC AACACCTTTA AGCACTTACA TGTTGACAAA 6420

CAGTGAGTTA CTATCATTAA TCAATGATAT GCCTATAACA AATGATCAGA AAAAATTAA1 6480 GTCAAGCAAT GTTCAGATAG TAAGGCAACA AAGTTATTCC ATCATGTCTA TAATAAAGGA 6540

AGAAGTCCTT GCATATGTTG TAGAGCTGCC TATCTATGGT GTAATAGATA CACCTTGCTG 6600

GAAATTGCAC ACATCGCCTC TATGCACTAC CAACATCAAA GAAGGATCAA ATATTTGTTT 6660

AACAAGGACT GATAGAGGAT GGTATTGTGA TAATGCAGGA TCAGTATCCT TCTTTCCACA 6720

GGCTGACACT TGTAAAGTAC AGTCCAATCG AGTATTTTGT GACACTATGA ACAGTTTGAC 6780

ATTACCAAGT GAAGTCAGCC TTTGTAACAC TGACATATTC AATTCCAAGT ATGACTGGAA 6840

AATTATGACA TCAAAAACAG ACATAAGCAG CTCAGTAATT ACTTCTCTTG GAGCTATAGT 6900

GTCATGCTAT GGTAAAACTA AATGCACTGC ATCCAACAAA AATCGTGGGA TTATAAAGAC 6960

ATTTTCTAAT GGTTGTGACT ATGTGTCAAA CAAAGGAGTA GATACTGTGT CAGTGGGCAA 7020

CACTTTATAC TATGTAAACA AGCTGGAAGG CAAGAACCTT TATGTAAAAG GGGAACCTAT 7080

AATAAATTAC TATGACCCTC TAGTGTTTCC TTCTGATGAG TTTGATGCAT CAATATCTCA 7140

AGTCAATGAA AAAATCAATC AAAGTTTAGC TTTTATTCGT AGATCTGATG AATTACTACA 7200

TAATGTAAAT ACTGGCAAAT CTACTACAAA TATTATGATA ACTACAATTA TTATAGTAAT 7260

CATTGTAGTA TTGTTATCAT TAATAGCTAT TGGTTTACTG TTGTATTGTA AAGCCAAAAA 7320

CAGACCAGTT ACACTAAGCA AAGACCAACT AAGTGGAATC AATAATATTG CATTCAGCAA 7380

ATAGACAAAA AACCACCTGA TCATGTTTCA ACAACAATCT GCTGACCACC AATCCCAAAT 7440

CAACTTACAA CAAATATTTC AACATCACAG TACAGGCTGA ATGATTTCCT CACATCATGC 7500

TACCCACATA ACTAAGCTAG ATCCTTAACT TATAGTTACA TAAAAACCTC AAGTATCACA 7560

ATCAACCACT AAATCAACAC ATCATTCACA AAATTAACAG CTGGGGCAAA TATGTCGCGA 7620

AGAAATCCTT GTAAATTTGA GATTAGAGGT CATTGCTTGA ATGGTAGAAG ATGTCACTAC 7680

AGTCATAATT ACTTTGAATG GCCTCCTCAT GCATTACTAG TGAGGCAAAA CTTCATGTTA 7740

AACAAGATAC TCAAGTCAAT GGACAAAAGC ATAGACACTT TGTCTGAAAT AAGTGGAGCT 7800

GCTGAACTGG ATAGAACAGA AGAATATGCT CTTGGTATAG TTGGAGTGCT AGAGAGTTAC 7860

ATAGGATCTA TAAACAACAT AACAAAACAA TCAGCATGTG TTGCTATGAG TAAACTTCTT 7920

ATTGAGATCA ATAGTGATGA CATTAAAAAG CTTAGAGATA ATGAAGAACC CAATTCACCT 7980

AAGATAAGAG TGTACAATAC TGTTATATCA TACATTGAGA GCAATAGAAA AAACAACAAG 8040 CAAACCATCC ATCTGCTCAA GAGACTACCA GCAGACGTGC TGAAGAAGAC AATAAAGAAC 8100

ACATTAGATA TCCACAAAAG CATAACCATA AGCAATCCAA AAGAGTCAAC TGTGAATGAT 8160

CAAAATGACC AAACCAAAAA TAATGATATT ACCGGATAAA TATCCTTGTA GTATATCATC 8220

CATATTGATC TCAAGTGAAA GCATGGTTGC TACATTCAAT CATAAAAACA TATTACAATT 8280

TAACCATAAC TATTTGGATA ACCACCAGCG TTTATTAAAT CATATATTTG ATGAAATTCA 8340

TTGGACACCT AAAAACTTAT TAGATGCCAC TCAACAATTT CTCCAACATC TTAACATCCC 8400

TGAAGATATA TATACAGTAT ATATAT AGT GTCATAATGC TTGACCA AA CGACTCTATG 8460

TCATCCAACC ATAAAACTAT TTTGATAAGG TTATGGGACA AAATGGATCC CATTATTAAT 8520

GGAAACTCTG CTAATGTGTA TCTAACTGAT AGTTATTTAA AAGGTGTTAT CTCTTTTTCA 8580

GAGTGTAATG CTTTAGGGAG TTATCTTTTT AACGGCCCTT ATCTTAAAAA TGATTACACC 8640

AACTTAATTA GTAGACAAAG CCCACTACTA GAGCATATGA ATCTTAAAAA ACTAACTATA 8700

ACACAGTCAT TAATATCTAG ATATCATAAA GGTGAACTGA AATTAGAAGA ACCAACTTAT 8760

TTCCAGTCAT TACTTATGAC ATATAAAAGT ATGTCCTCGT CTGAACAAAT TGCTACAACT 8820

AACTTACTTA AAAAAATAAT ACGAAGAGCC ATAGAAATAA GTGATGTAAA GGTGTACGCC 8880

ATCTTGAATA AACTAGGATT AAAGGAAAAG GACAGAGTTA AGCCCAACAA TAATTCAGGT 8940

GATGAAAACT CAGTACTTAC AACTATAATT AAAGATGATA TACTTTCGGC TGTGGAAAAC 9000

AATCAATCAT ATACAAATTC AGACAAAAGT CACTCAGTAA ATCAAAATAT CACTATCAAA 9060

ACAACACTCT TGAAAAAATT GATGTGTTCA ATGCAACATC CTCCATCATG GTTAATACAC 9120

TGGTTCAATT TATATACAAA ATTAAATAAC ATATTAACAC AATATCGATC AAATGAGGTA 9180

AAAAGTCATG GGTTTATATT AATAGATAAT CAAACTTTAA GTGGTTTTCA GTTTATTTTA 9240

AATCAATATG GTTGTATCGT TTATCATAAA GGACTCAAAA AAATCACAAC TACTACTTA.: 9300

AATCAATTTT TGACATGGAA AGACATCAGC CTTAGCAGAT TAAATGTTTG CTTAATTACT 9360

TGGATAAGTA ATTGTTTAAA TACATTAAAC AAAAGCTTAG GGCTGAGATG TGGATTCAAT 9420

AATGTTGTGT TATCAGAATT ATTTCTTTAT GGAGATTGTA TACTGAAATT ATTTCATAAT 9480

GAAGGCTTCT ACATAATAAA AGAAGTAGAG GGATTTATTA TGTCTTTAAT TCTAAACAT&. 9540

ACAGAAGAAG ATCAATTTAG GAAACGATTT TATAATAGCA TGCTAAATAA CATCACAGAr 9600 GCAGCTATTA AGGCTCAAAA GGACCTACTA TCAAGAGTAT GTCACACTTT ATTAGACAAG 9660

ACAGTGTCTG ATAATATCAT AAATGGTAAA TGGATAATCC TATTAAGTAA ATTTCTTAAA 9720

TTGATTAAGC TTGCAGGTGA TAATAATCTC AATAACTTGA GTGAGCTATA TTTTCTCTTC 9780

AGAATCTTTG GACATCCAAT GGTCGATGAA AGACAAGCAA TGGATTCTGT AAGAATTAAC 9840

TGTAATGAAA CTAAGTTCTA CTTATTAAGT AGTCTAAGTA CATTAAGAGG TGCTTTCATT 9900

TATAGAATCA TAAAAGGGTT TGTAAATACC TACAACAGAT GGCCCACCTT AAGGAATGCT 9960

ATTGTCCTAC CTCTAAGATG GTTAAACTAC TATAAACTTA ATACTTATCC ATCTCTACTT 10020

GAAATCACAG AAAATGATTT GATTATTTTA TCAGGATTGC GGTTCTATCG TGAGTTTCAT 10080

CTGCCTAAAA AAGTGGATCT TGAAATGATA ATAAATGACA AAGCCATTTC ACCTCCAAAA 10140

GATCTAATAT GGACTAGTTT TCCTAGAAAT TACATGCCAT CACATATACA AAATTATATA 10200

GAACATGAAA AGTTGAAGTT CTCTGAAAGC GACAGATCGA GAAGAGTACT AGAGTATTAC 10260

TTGAGAGATA ATAAATTCAA TGAATGCGAT CTATACAATT GTGTAGTCAA TCAAAGCTAT 10320

CTCAACAACT CTAATCACGT GGTATCACTA ACTGGTAAAG AAAGAGAGCT CAGTGTAGGT 10380

AGAATGTTTG CTATGCAACC AGGTATGTTT AGGCAAATCC AAATCTTAGC AGAGAAAATG 10440

ATAGCTGAAA ATATTTTACA ATTCTTCCCT GAGAGTTTGA CAAGATATGG TGATCTAGAG 10500

CTTCAAAAGA TATTAGAATT AAAAGCAGGA ATAAGCAACA AGTCAAATCG TTATAATGAT 10560

AACTACAACA ATTATATCAG TAAATGTTCT ATCATTACAG ATCTTAGCAA ATTCAATCAG 10620

GCATTTAGAT ATGAAACATC ATGTATCTGC AGTGATGTAT TAGATGAACT GCATGGAGTA 10680

CAATCTCTGT TCTCTTGGTT GCATTTAACA ATACCTCTTG TCACAATAAT ATGTACATAT 10740

AGACATGCAC CTCCTTTCAT AAAGGATCAT GTTGTTAATC TTAATGAGGT TGATGAACAA 10800

AGTGGATTAT ACAGATATCA TATGGGTGGT ATTGAGGGCT GGTGTCAAAA ACTGTGGACC 10860

ATTGAAGCTA TATCATTATT AGATCTAATA TCTCTCAAAG GGAAATTCTC TATCACAGCT 10920

CTGATAAATG GTGATAATCA GTCAATTGAT ATAAGCAAAC CAGTTAGACT TATAGAGGGT 10980

CAGACCCATG CACAAGCAGA TTATTTGTTA GCATTAAATA GCCTTAAATT GTTATATAAA 11040

GAGTATGCAG GTATAGGCCA TAAGCTTAAG GGAACAGAGA CCTATATATC CCGAGATATG 11100

CAGTTCATGA GCAAAACAAT CCAGCACAAT GGAGTGTACT ATCCAGCCAG TATCAAAAAA 11160 CCTAATAGAA TTATTCTCAT ACCGAAGCTG AATGAGATAC ATTTGATGAA ACCTCCTATA 12780

TTTACAGGAG ATGTTGATAT CATCAAGTTG AAGCAAGTGA TACAAAAGCA GCACATGTTC 12840

CTACCAGATA AAATAAGTTT AACCCAATAT GTAGAATTAT TCTTAAGTAA CAAAGCACTT 12900

AAATCTGGAT CTCACATCAA CTCTAATTTA ATATTAGTAC ATAAAATGTC TGATTATTTT 12960

CATAATGCTT ATATTTTAAG TACTAATTTA GCTGGACATT GGATTCTGAT TATTCAACTT 13020

ATGAAAGATT CAAAAGGTAT TTTTGAAAAA GATTGGGGAG AGGGGTACAT AACTGATCAT 13080

ATGTTCATTA ATTTGAATGT TTTCTTTAAT GCTTATAAGA CTTATTTGCT ATGTTTTCAT 13140

AAAGGTTATG GTAAAGCAAA ATTAGAATGT GATATGAACA CTTCAGATCT TCTTTGTGTT 13200

TTGGAGTTAA TAGACAGTAG CTACTGGAAA TCTATGTCTA AAGTTTTCCT AGAACAAAAA 13260

GTCATAAAAT ACATAGTCAA TCAAGACACA AGTTTGCGTA GAATAAAAGG CTGTCACAGT 13320

TTTAAGTTGT GGTTTTTAAA ACGCCTTAAT AATGCTAAAT TTACCGTATG CCCTTGGGTT 13380

GTTAACATAG ATTATCACCC AACACACATG AAAGCTATAT TATCTTACAT AGATTTAGTT 13440

AGAATGGGGT TAATAAATGT AGATAAATTA ACCATTAAAA ATAAAAACAA ATTCAATGAT 13500

GAATTTTACA CATCAAATCT CTTTTACATT AGTTATAACT TTTCAGACAA CACTCATTTG 13560

CTAACAAAAC AAATAAGAAT TGCTAATTCA GAATTAGAAG ATAATTATAA CAAACTATAT 13620

CACCCAACCC CAGAAACTTT AGAAAATATG TCATTAATTC CTGTTAAAAG TAATAATAGT 13680

AACAAACCTA AATTTTGTAT AAGTGGAAAT ACCGAATCTA TGATGATGTC AACATTCTCT 13740

AGTAAAATGC ATATTAAATC TTCCACTGTT ACCACAAGAT TCAATTATAG CAAACAAGAC 13800

TTGTACAATT TATTTCCAAT TGTTGTGATA GACAAGATTA TAGATCATTC AGGTAATACA 13860

GCAAAATCTA ACCAACTTTA CACCACCACT TCACATCAGA CATCTTTAGT AAGGAATAGT 13920

GCATCACTTT ATTGCATGCT TCCTTGGCAT CATGTCAATA GATTTAACTT TGTATTTAGT 13980

TCCACAGGAT GCAAGATCAG TATAGAGTAT ATTTTAAAAG ATCTTAAGAT TAAGGACCCC 14040

AGTTGTATAG CATTCATAGG TGAAGGAGCT GGTAACTTAT TATTACGTAC GGTAGTAGAA 14100

CTTCATCCAG ACATAAGATA CATTTACAGA AGTTTAAAAG ATTGCAATGA TCATAGTTTA 14160

CCTATTGAAT TTCTAAGGTT ATACAACGGG CATATAAACA TAGATTATGG TGAGAATTTA 14220

ACCATTCCTG CTACAGATGC AACTAATAAC ATTCATTGGT CTTATTTACA TATAAAATTT 14280 GCAGAACCTA TTAGCATCTT TGTCTGCGAT GCTGAATTAC CTGTTACAGC CAATTGGAGT 14340

AAAATTATAA TTGAATGGAG TAAGCATGTA AGAAAGTGCA AGTACTGTTC TTCTGTAAAT 14400

AGATGCATTT TAATTGCAAA ATATCATGCT CAAGATGACA TTGATTTCAA ATTAGATAAC 14460

ATTACTATAT TAAAAACTTA CGTGTGCCTA GGTAGCAAGT TAAAAGGATC TGAAGTTTAC 14520

TTAATCCTTA CAATAGGCCC TGCAAATATA CTTCCTGTTT TTGATGTTGT ACAAAATGCT 14580

AAATTGATAC TTTCAAGAAC TAAAAATTTC ATTATGCCTA AAAAAACTGA CAAGGAATCT 14640

ATCGATGCAG ATATTAAAAG CTTAATACCT TTCCTTTGTT ACCCTATAAC AAAAAAAGGA 14700

ATTAAGACTT CATTGTCAAA ATTGAAGAGT GTAGTTAATG GAGATATATT ATCATATTCT 14760

ATAGCTGGAC GTAATGAAGT ATTCAGCAAC AAGCTTATAA ACCACAAGCA TATGAATATC 14820

CTAAAATGGC TAGATCATGT TTTAAATTTT AGATCAGCTG AACTTAATTA CAATCATTTA 14880

TACATGATAG AGTCCACATA TCCTTACTTA AGTGAATTGT TAAATAGTTT AACAACCAAT 14940

GAGCTCAAGA AGCTGATTAA AATAACAGGT AGTGTGCTAT ACAACCTTCC CAACGAACAG 15000

TAGTTTAAAA TATCATTAAC AAGTTTGGTC AAATTTAGAT GCTAACACAT CATTATATTA 15060

TAGTTATTAA AAAATATACA AACTTTTCAA TAATTTAGCA TATTGATTCC AAAATTATCA 15120

TTTTAGTCTT AAGGGGTTAA ATAAAAGTCT AAAACTAACA ATTATACATG TGCATTCACA 15180

ACACAACGAG ACATTAGTTT TTGACACTTT TTTTCTCGT 15219 (2) INFORMATION FOR SEQ ID NO: 30:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid <C) STRANDEDNESS: (D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 30:

Met Asp Pro He He Asn Gly Asn Ser Ala Asn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lys Gly Val He Ser Phe Ser Glu Cys Asn Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Asn Gly Pro Tyr Leu Lys Asn Asp Tyr Thr Asn Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu His Met Asn Leu Lys Lys Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr His Lys Gly Glu Leu Lys 65 70 75 80

Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lys He 100 105 110

He Arg Arg Ala He Glu He Ser Asp Val Lys Val Tyr Ala He Leu 115 120 125

Asn Lys Leu Gly Leu Lye Glu Lye Aβp Arg Val Lys Pro Asn Asn Aβn 130 135 140

Ser Gly Aep Glu Aβn Ser Val Leu Thr Thr He He Lye Aβp Aβp He 145 150 155 160

Leu Ser Ala Val Glu Aβn Aβn Gin Ser Tyr Thr Asn Ser Aβp Lye Ser 165 170 175

Hiβ Ser Val Asn Gin Aβn He Thr He Lye Thr Thr Leu Leu Lye Lye 180 185 190

Leu Met Cyβ Ser Met G n Hiβ Pro Pro Ser Trp Leu He Hiβ Trp Phe 195 200 205

Aβn Leu Tyr Thr Lys Leu Aβn Aβn He Leu Thr Gin Tyr Arg Ser Aβn 210 215 220

Glu Val Lye Ser Hiβ Gly Phe He Leu He Aβp Aβn Gin Thr Leu Ser 225 230 235 240

Gly Phe Gin Phe He Leu Aen Gin Tyr Gly Cyβ He Val Tyr Hiβ Lye 245 250 255

Gly Leu Lye Lys He Thr Thr Thr Thr Tyr Asn Gin Phe Leu Thr Trp 260 265 270

Lye Aβp He Ser Leu Ser Arg Leu Aβn Val Cyβ Leu He Thr Trp He 275 280 285

Ser Aβn Cye Leu Asn Thr Leu Asn Lys Ser Leu Gly Leu Arg Cys Gly 290 295 300 Phe Asn Asn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Aβp Cyβ He 305 310 315 320

Leu Lye Leu Phe Hiβ Aβn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Asn He Thr Glu Glu Asp Gin Phe 340 345 350

Arg Lys Arg Phe Tyr Aβn Ser Met Leu Asn Asn He Thr Aβp Ala Ala 355 360 365

He Lye Ala Gin Lye Aβp Leu Leu Ser Arg Val Cyβ His Thr Leu Leu 370 375 380

Aβp Lye Thr Val Ser Aβp Aβn He He Aβn Gly Lye Trp He He Leu 385 390 395 400

Leu Ser Lye Phe Leu Lys Leu He Lys Leu Ala Gly Asp Asn Aβn Leu 405 410 415

Aβn Aβn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly Hiβ Pro 420 425 430

Met Val Aβp Glu Arg Gin Ala Met Aβp Ser Val Arg He Aβn Cyβ Asn 435 440 445

Glu Thr Lye Phe Tyr Leu Leu Ser Ser Leu Ser Thr Leu Arg Gly Ala 450 455 460

Phe He Tyr Arg He He Lys Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Asn Tyr 485 490 495

Tyr Lys Leu Asn Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Aβn Aβp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe Hiβ Leu Pro 515 520 525

Lye Lys Val Asp Leu Glu Met He He Asn Asp Lys Ala He Ser Pro 530 535 540

Pro Lys Asp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

His He Gin Asn Tyr He Glu His Glu Lys Leu Lys Phe Ser Glu Ser 565 570 575 Asp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Asp Asn Lys Phe 580 585 590

Asn Glu Cys Aβp Leu Tyr Aβn Cyβ Val Val Asn Gin Ser Tyr Leu Asn 595 600 605

Aβn Ser Aβn Hiβ Val Val Ser Leu Thr Gly Lye Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lye Met He Ala Glu Asn He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Asp Leu Glu Leu Gin Lys He Leu Glu 660 665 670

Leu Lys Ala Gly He Ser Aβn Lye Ser Aβn Arg Tyr Aβn Aβp Aβn Tyr 675 680 685

Asn Asn Tyr He Ser Lys Cys Ser He He Thr Asp Leu Ser Lys Phe 690 695 700

Asn Gin Ala Phe Arg Tyr Glu Thr Ser Cys He Cys Ser Asp Val Leu 705 710 715 720

Asp Glu Leu His Gly Val Gin Ser Leu Phe Ser Trp Leu Hiβ Leu Thr 725 730 735

He Pro Leu Val Thr He He Cys Thr Tyr Arg Hiβ Ala Pro Pro Phe 740 745 750

He Lys Aβp His Val Val Asn Leu Asn Glu Val Asp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr His Met Gly Gly He Glu Gly Trp Cys Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Asp Leu He Ser Leu Lys Gly 785 790 795 800

Lys Phe Ser He Thr Ala Leu He Asn Gly Asp Asn Gin Ser He Asp 805 810 815

He Ser Lys Pro Val Arg Leu He Glu Gly Gin Thr His Ala Gin Ala 820 825 830

Asp Tyr Leu Leu Ala Leu Asn Ser Leu Lys Leu Leu Tyr Lys Glu Tyr 835 840 845

Ala Gly He Gly His Lys Leu Lys Gly Thr Glu Thr Tyr He Ser Arg 850 855 860

Asp Met Gin Phe Met Ser Lys Thr He Gin His Asn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lys Lys Val Leu Arg Val Gly Pro Trp He Asn Thr 885 890 895

He Leu Asp Asp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910

Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cys Ser Leu He Phe 915 920 925

Arg Asn He Trp Leu Tyr Aβn Gin He Ala Leu Gin Leu Arg Aβn His 930 935 940

Ala Leu Cys Asn Aβn Lye Leu Tyr Leu Aβp He Leu Lye Val Leu Lye 945 950 955 960

Hiβ Leu Lys Thr Phe Phe Asn Leu Aβp Ser He Aβp Met Ala Leu Ser 965 970 975

Leu Tyr Met Aβn Leu Pro Met Leu Phe Gly Gly Gly Asp Pro Asn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Aβp Phe Leu Thr Glu Ala 995 1000 1005

He Val Hiβ Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly Hiβ Aβp Leu 1010 1015 1020

Gin Aβp Lye Leu Gin Aβp Leu Pro Aβp Asp Arg Leu Asn Lys Phe Leu 1025 1030 1035 1040

Thr Cys Val He Thr Phe Asp Lye Asn Pro Asn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Asp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lys He 1060 1065 1070

Thr Ser Glu He Asn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Asn Lys He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Asn Asp He Met Gin Asn He Glu Pro Thr Tyr Pro His 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lys Ala Glu Lys 1125 1130 1135 He Val Asn Leu He Ser Gly Thr Lye Ser He Thr Aβn He Leu Glu 1140 1145 1150

Lys Thr Ser Ala He Asp Thr Thr Asp He Asn Arg Ala Thr Asp Met 1155 1160 1165

Met Arg Lys Asn He Thr Leu Leu He Arg He Leu Pro Leu Aβp Cyβ 1170 1175 1180

Aβn Lys Asp Lys Arg Glu Leu Leu Ser Leu Glu Aβn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lye Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Aβn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asp He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Asn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lys Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lys Lye Thr Met Pro Val Tyr Aβn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lys Lys Gin Arg Asp Gin He Asp Leu Leu Ala Lys Leu Asp 1285 1290 1295

Trp Val Tyr Ala Ser He Asp Asn Lys Asp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lys Ala Lye Lys Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Asn Tyr Leu His Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cys Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Asn 1345 1350 1355 1360

Tyr His Phe Aβp Thr Ser Pro He Aβn His Val Leu Thr Glu Lys Tyr 1365 1370 1375

Gly Asp Glu Aβp He Aβp He Val Phe Gin Aan Cys He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Asn He Cys Pro Asn 1395 1400 1405 Arg He He Leu He Pro Lys Leu Aβn Glu He Hiβ Leu Met Lys Pro 1410 1415 1420

Pro He Phe Thr Gly Asp Val Asp He He Lye Leu Lye Gin Val He 1425 1430 1435 1440

Gin Lys Gin His Met Phe Leu Pro Asp Lys He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Aβn Lys Ala Leu Lys Ser Gly Ser His He 1460 1465 1470

Asn Ser Aβn Leu He Leu Val Hiβ Lys Met Ser Asp Tyr Phe His Aβn 1475 1480 1485

Ala Tyr He Leu Ser Thr Asn Leu Ala Gly His Trp He Leu He He 1490 1495 1500

Gin Leu Met Lys Asp Ser Lys Gly He Phe Glu Lys Asp Trp Gly Glu 1505 1510 1515 1520

Gly Tyr He Thr Asp His Met Phe He Asn Leu Asn Val Phe Phe Aβn 1525 1530 1535

Ala Tyr Lys Thr Tyr Leu Leu Cys Phe His Lys Gly Tyr Gly Lys Ala 1540 1545 1550

Lys Leu Glu Cys Aβp Met Aβn Thr Ser Aβp Leu Leu Cye Val Leu Glu 1555 1560 1565

Leu He Aβp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580

Gin Lys Val He Lys Tyr He Val Asn Gin Asp Thr Ser Leu Arg Arg 1585 1590 1595 1600

He Lye Gly Cyβ Hiβ Ser Phe Lys Leu Trp Phe Leu Lys Arg Leu Asn 1605 1610 1615

Aβn Ala Lye Phe Thr Val Cys Pro Trp Val Val Aen He Asp Tyr His 1620 1625 1630

Pro Thr His Met Lys Ala He Leu Ser Tyr He Asp Leu Val Arg Met 1635 1640 1645

Gly Leu He Asn Val Aβp Lye Leu Thr He Lye Aβn Lye Aen Lye Phe 1650 1655 1660

Aen Aβp Glu Phe Tyr Thr Ser Aβn Leu Phe Tyr He Ser Tyr Aβn Phe 1665 1670 1675 1680

Ser Aβp Asn Thr His Leu Leu Thr Lye Gin He Arg He Ala Aβn Ser 1685 1690 1695

Glu Leu Glu Asp Asn Tyr Asn Lys Leu Tyr His Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Asn Met Ser Leu He Pro Val Lye Ser Aen Asn Ser Asn Lys 1715 1720 1725

Pro Lys Phe Cys He Ser Gly Asn Thr Glu Ser Met Met Met Ser Thr 1730 1735 1740

Phe Ser Ser Lys Met His He Lys Ser Ser Thr Val Thr Thr Arg Phe 1745 1750 1755 1760

Aβn Tyr Ser Lye Gin Aβp Leu Tyr Aβn Leu Phe Pro He Val Val He 1765 1770 1775

Aβp Lye He He Aβp His Ser Gly Aβn Thr Ala Lye Ser Aβn Gin Leu 1780 1785 1790

Tyr Thr Thr Thr Ser Hiβ Gin Thr Ser Leu Val Arg Aβn Ser Ala Ser 1795 1800 1805

Leu Tyr Cyβ Met Leu Pro Trp Hiβ Hiβ Val Aβn Arg Phe Aβn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cyβ Lye He Ser He Glu Tyr He Leu Lye Aβp 1825 1830 1835 1840

Leu Lye He Lye Aβp Pro Ser Cyβ He Ala Phe He Gly Glu Gly Ala 1845 1850 1855

Gly Aβn Leu Leu Leu Arg Thr Val Val Glu Leu Hiβ Pro Aβp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lye Asp Cys Aβn Asp His Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Aβn Gly Hiβ He Asn He Asp Tyr Gly Glu 1890 1895 1900

Asn Leu Thr He Pro Ala Thr Aβp Ala Thr Aβn Aβn He Hiβ Trp Ser 1905 1910 1915 1920

Tyr Leu His He Lye Phe Ala Glu Pro He Ser He Phe Val Cyβ Aβp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Aβn Trp Ser Lys He He He Glu Trp 1940 1945 1950

Ser Lys His Val Arg Lys Cy^s Ly^s Tyr Cys Ser Ser Val Asn Arg Cys 1955 1960 1965 He Leu He Ala Lys Tyr His Ala Gin Asp Asp He Asp Phe Lye Leu 1970 1975 1980

Aβp Aβn He Thr He Leu Lys Thr Tyr Val Cys Leu Gly Ser Lys Leu 1985 1990 1995 2000

Lys Gly Ser Glu Val Tyr Leu He Leu Thr He Gly Pro Ala Asn He 2005 2010 2015

Leu Pro Val Phe Asp Val Val Gin Asn Ala Lys Leu He Leu Ser Arg 2020 2025 2030

Thr Lys Aβn Phe He Met Pro Lye Lys Thr Asp Lys Glu Ser He Aβp 2035 2040 2045

Ala Aβp He Lye Ser Leu He Pro Phe Leu Cye Tyr Pro He Thr Lye 2050 2055 2060

Lye Gly He Lye Thr Ser Leu Ser Lye Leu Lye Ser Val Val Aβn Gly 2065 2070 2075 2080

Aβp He Leu Ser Tyr Ser He Ala Gly Arg Aβn Glu Val Phe Ser Aβn 2085 2090 2095

Lys Leu He Asn Hiβ Lys His Met Asn He Leu Lys Trp Leu Asp His 2100 2105 2110

Val Leu Asn Phe Arg Ser Ala Glu Leu Asn Tyr Asn His Leu Tyr Met 2115 2120 2125

He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Aβn Ser Leu Thr 2130 2135 2140

Thr Aβn Glu Leu Lye Lye Leu He Lys He Thr Gly Ser Val Leu Tyr 2145 2150 2155 2160

Asn Leu Pro Asn Glu Gin 2165

(2) INFORMATION FOR SEQ ID NO: 31:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15219 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

( ii ) MOLECULE TYPE : RNA (genomic ) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 31:

ACGGGAAAAA AATGCGTACT ACAAACTTGC ACATTCGAAA AAAATGGGGC AAATAAGAAC 60

TTGATAAGTG CTATTTAAGT CTAACCTTTT CAATCAGAAA TGGGGTGCAA TTCACTGAGC 120

ATGATAAAGG TTAGATTACA AAATTTATTT GACAATGACG AAGTAGCATT GTTAAAAATA 180

ACATGTTATA CTGATAAATT AATTCTTCTG ACCAATGCAT TAGCCAAAGC AGCAATACAT 240

ACAATTAAAT TAAACGGCAT AGTTTTTATA CATGTTATAA CAAGCAGTGA AGTGTGCCCT 300

GATAACAATA TTGTAGTGAA ATCTAACTTT ACAACAATGC CAATACTACA AAATGGAGGA 360

TACATATGGG AATTGATTGA GTTGACACAC TGCTCTCAAT TAAACGGTTT AATGGATGAT 420

AATTGTGAAA TCAAATTTTC TAAAAGACTA AGTGACTCAG TAATGACTAA TTATATGAAT 480

CAAATATCTG ACTTACTTGG GCTTGATCTC AATTCATGAA TTATGTTTAG TCTAATTCAA 540

TAGACATGTG TTTATTACCA TTTTAGTTAA TATAAAAACT CATGAAAGGG AAATGGGGGA 600

AATAAACTCA CCTAATCAAT CAAACCATGA GCACTACAAA TGACAACACT ACTATGCAAA 660

GATTGATGAT CACAGACATG AGACCCCTGT CAATGGATTC AATAATAACA TCTCTTACCA 720

AAGAAATCAT CACACACAAA TTCATATACT TGATAAACAA TGAATGTATT GTAAGAAAAC 780

TTGATGAAAG ACAAGCTACA TTTACATTCT TAGTCAATTA TGAGATGAAG CTACTGCACA 840

AAGTAGGGAG TACCAAATAC AAAAAATACA CTGAATATAA TACAAAATAT GGCACTTTCC 900

CCATGCCTAT ATTTATCAAT CACGGCGGGT TTCTAGAATG TATTGGCATT AAGCCTACAA 960

AACACACTCC TATAATATAC AAATATGACC TCAACCCGTG AATTCCAACA AAAAAACCAA 1020

CCGAACCAAA CCAAACTATT CCTGAAACAA GAGTGCTCAA TAGTTAAGAA GGAGCTAATC 1080

CATTTTAGTA ATTAAAAATA AAAGTAAAGC CAATAACATA AATTGGGGCA AATACAAAGA 1140

TGGCTCTTAG CAAAGTCAAG TTGAATGATA CATTAAATAA GGATCAGCTG CTGTCATCCA 1200

GCAAATACAC TATTCAACGT AGTACAGGAG ATAATATTGA CACTCCCAAT TATGATGTGC 1260

AAAAACACCT AAACAAACTA TGTGGTATGC TATTAATCAC TGAAGATGCA AATCATAAAT 1320

TCACAGGATT AATAGGTATG TTATATGCTA TGTCCAGGTT AGGAAGGGAA GACACTATAA 1380

AGATACTTAA AGATGCTGGA TATCATGTTA AAGCTAATGG AGTAGATATA ACAACATATC 1440

GTCAAGATAT AAATGGAAAG GAAATGAAAT TCGAAGTATT AACATTATCA AGCTTGACAT 1500 CAGAAATACA AGTCAATATT GAGATAGAAT CTAGAAAGTC CTACAAAAAA ATGCTAAAAG 1560

AGATGGGAGA AGTGGCTCCA GAATATAGGC ATGATTCTCC AGACTGTGGG ATGATAATAC 1620

TGTGTATAGC TGCACTTGTG ATAACCAAAT TAGCAGCAGG AGACAGATCA GGTCTTACAG 1680

CAGTAATTAG GAGGGCAAAC AATGTCTTAA AAAACGAAAT AAAACGATAC AAGGGCCTCA 1740

TACCAAAGGA TATAGCTAAC AGTTTTTATG AAGTGTTTGA AAAACACCCT CATCTTATAG 1800

ATGTTTTCGT GCACTTTGGC ATTGCACAAT CATCCAGAAG AGGGGGTAGT AGAGTTGAAG 1860

GAATCTTTGC AGGATTGTTT ATGAATGCCT ATGGTTCAGG GCAAGTAATG CTAAGATGGC! 1920

GAGTTTTAGC CAAATCTGTA AAAAATATCA TGCTAGGACA TGCTAGTGTC CAGGCAGAAA 1980

TGGAGCAAGT TGTGGAAGTC TATGAGTATG CACAGAAGTT GGGAGGAGAA GCTGGATTCT 2040

ACCATATATT GAACAATCCA AAAGCATCAT TGCTGTCATT AACTCAATTT CCCAACTTCr 2100

CAAGTGTGGT CCTAGGCAAT GCAGCAGGTC TAGGCATAAT GGGAGAGTAT AGAGGTACAC: 2160

CAAGAAACCA GGATCTTTAT GATGCAGCTA AAGCATATGC AGAGCAACTC AAAGAAAATC5 2220

GAGTAATAAA CTACAGTGTA TTAGACTTAA CAGCAGAAGA ATTGGAAGCC ATAAAGCATC 2280

AACTCAACCC CAAAGAAGAT GATGTAGAGC TTTAAGTTAA CAAAAAATAC GGGGCAAATA 2340

AGTCAACATG GAGAAGTTTG CACCTGAATT TCATGGAGAA GATGCAAATA ACAAAGCTAC 2400

CAAATTCCTA GAATCAATAA AGGGCAAGTT CGCATCATCC AAAGATCCTA AGAAGAAAGA 2460

TAGCATAATA TCTGTTAACT CAATAGATAT AGAAGTAACT AAAGAGAGCC CGATAACATC 2520

TGGCACCAAC ATCATCAATC CAACAAGTGA AGCCGACAGT ACCCCAGAAA CAAAAGCCAA 2580

CTACCCAAGA AAACCCCTAG TAAGCTTCAA AGAAGATCTC ACCCCAAGTG ACAACCCTT 2640

TTCTAAGTTG TACAAGGAAA CAATAGAAAC ATTTGATAAC AATGAAGAAG AATCTAGCTΛ 2700

CTCATATGAA GAGATAAATG ATCAAACAAA TGACAACATT ACAGCAAGAC TAGATAGAAT 2760

TGATGAAAAA TTAAGTQAAA TATTAGGAAT GCTCCATACA TTAGTAGTTG CAAGTGCAGG 2820

ACCCACTTCA GCTCGCGATG GAATAAGAGA TGCTATGGTT GGTCTAAGAG AAGAGATGAT 2880

AGAAAAAATA AGAGCGGAAG CATTAATGAC CAATGATAGG TTAGAGGCTA TGGCAAGACT 2 40

TAGGAATGAG GAAAGCGAAA AAATGGCAAA AGACACCTCA GATGAAGTGT CTCTTAATCC 3000

AACTTCGAAA AAATTGAGTG ACTTGTTGGA AGACAACGAT AGTGACAATG ATCTATCACT 3060 TGATGATTTT TGATCAGCGA TCAACTCACT CAGCAATCAA CAACATCAAT AAAACAGACA 3120

TCAATCCATT GAATCAACTG CCAGACCGAA CAAACAAACG TCCATCAGTA GAACCACCAA 3180

CCAATCAATC AACCAATTGA TCAATCAGCA ACCCGACAAA ATTAACAATA TAGTAACAAA 3240

AAAAGAACAA GATGGGGCAA ATATGGAAAC ATACGTGAAC AAGCTTCACG AAGGCTCCAC 3300

ATACACAGCA GCTGTTCAGT ACAATGTTCT AGAAAAAGAT GATGATCCTG CATCACTAAC 3360

AATATGGGTG CCTATGTTCC AGTCATCTGT GCCAGCAGAC TTGCTCATAA AAGAACTTGC 3420

AAGCATCAAT ATACTAGTGA AGCAGATCTC TACGCCCAAA GGACCTTCAC TACGAGTCAC 3480

GATTAACTCA AGAAGTGCTG TGCTGGCTCA AATGCCTAGT AATTTCATCA TAAGCGCAAA 3540

TGTATCATTA GATGAAAGAA GCAAATTAGC ATATGATGTA ACTACACCTT GTGAAATCAA 3600

AGCATGCAGT CTAACATGCT TAAAAGTAAA AAGTATGTTA ACTACAGTCA AAGATCTTAC 3660

CATGAAGACA TTCAACCCCA CTCATGAGAT CATTGCTCTA TGTGAATTTG AAAATATTAT 3720

GAGATCAAAA AGAGTAATAA TACCAACCTA TCTAAGATCA ATTAGTGTCA AGAACAAGGA 3780

TCTGAACTCA CTAGAAAATA TAGCAACCAC CGAATTCAAA AATGCTATCA CCAATGCAAA 3840

AATTATTCCT TATGCAGGAT TAGTGTTAGT TATCACAGTT ACTGACAATA AAGGAGCATT 3900

CAAATATATC AAACCACAGA GTCAATTTAT AGTAGATCTT GGTGCCTACC TAGAAAAAGA 3960

GAGCATATAT TATGTGACTA CTAATTGGAA GCATACAGCT AGACGTTTTT CAATCAAACC 4020

ACTAGAGGAT TAAACTTAAT TATCAACACT GAATGACAGG TCCACATATA TCCTCAAACT 4080

ACACACTATA TCCAAACATC ATAAACATCT ACACTACACA CTTCATGACA CAAACCAATC 4140

CCACTCAAAA TCCAAAATCA CTACCAGCCA CTATCCGCTA GACCTAGAGT GCGAATAGGC 4200

AAATAAAACC AAAATATGGG GTAAATAGAC ATTAGTTAGA GTTCAATCAA TCTTAACAAC 4260

GATTTATACC GCCAATTCAA CACATATACT ATAAATCTTA AAATGGGAAA TACATCGATC 4320

ACAATAGAAC TCACAAGCAA ATTTTGGCCC TATTTTACAC TAATACATAT GATCTTAACT 4380

CTAATCTTTT TACTAATTAT AATCACTATC ATGATTGCAA CACTAAATAA GCTAAGTGAA 4440

CACAAAGCAT TCTGCAACAA AACTCTTGAA CTAGGACAGA TGTACCAAAT CAACACAGAG 4500

AGTTCCACCA TTATGCTGTG TCAAACCATA ATCCTGTATA TACAAACAAA CAAATCCAAT 4560

CCTCTCACAG AGTCACGGTG TCGCAAAACC ACGCTAACCA TCATGGTAGC ATAGAGTAGT 46 0 TATTTAAAAA TTAACATAAT GATGAATTGT TAGTATGAGA TCAAAAACAA CATTGGGGCA 4680

AATGCAACCA TGTCCAAACA CAAGAATCAA CGCACTGCCA GGACTCTAGA AAAGACCTGG 4740

GATACTCTTA ATCATCTAAT TGTAATATCC TCTTGTTTAT ACAGATTAAA TTTAAAATCT 4800

ATAGCACAAA TAGCACTATC AGTTTTGGCA ATGATAATCT CAACCTCTCT CATAATTGCA 4860

GCCATAATAT TCATCATCTC TGCCAATCAC AAAGTTACAC TAACAACGGT CACAGTTCAA 4920

ACAATAAAAA ACCACACTGA AAAAAACATC ACCACCTACC CTACTCAAGT CTCACCAGAA 4980

AGGGTTAGTT CATCCAAGCA ACCCACAACC ACATCACCAA TCCACACAAG TTCAGCTACA 5040

ACATCACCCA ATACAAAATC AGAAACACAC CATACAACAG CACAAACCAA AGGCAGAACC 5100

ACCACTTCAA CACAGACCAA CAAGCCAAGC ACAAAACCAC GTCCAAAAAA TCCACGAAAA 5160

AAAGATGATT ACCATTTTGA AGTGTTCAAC TTCGTTCCCT GCAGTATATG TGGCAACAAT 5220

CAACTTTGCA AATCCATCTG CAAAACAATA CCAAGCAACA AACCAAAGAA GAAACCAACC 5280

ATCAAACCCA CAAACAAACC AACCACCAAA ACCACAAACA AAAGAGACCC AAAAACACCA 5340

GCCAAAACGA CGAAAAAAGA AACTACCACC AACCCAACAA AAAAACTAAC CCTCAAGACC: 5400

ACAGAAAGAG ACACCAGCAC CTCACAATCC ACTGCACTCG ACACAACCAC ATTAAAACAC! 5460

ACAGTCCAAC AGCAATCCCT CCTCTCAACC ACCCCCGAAA ACACACCCAA CTCCACACAA 5520

ACACCCACAG CATCCGAGCC CTCCACACCA AACTCCACCC AAAAAACCCA GCCACATGCT 5580

TAGTTATTCA AAAACTACAT CTTAGCAGAG AACCGTGATC TATCAAGCAA GAACGAAATT 5640

AAACCTGGGG CAAATAACCA TGGAGTTGAT GATCCACAAG TCAAGTGCAA TCTTCCTAAC 5700

TCTTGCTATT AATGCATTGT ACCTCACCTC AAGTCAGAAC ATAACTGAGG AGTTTTACCA 5760

ATCGACATGT AGTGCAGTTA GCAGAGGTTA TTTTAGTGCT TTAAGAACAG GTTGGTATAG 5820

TAGTGTCATA ACAATAGAAT TAAGTAATAT AAAAGAAACC AAATGCAATG GAACTGACAC 5880

TAAAGTAAAA CTTATGAAAC AAGAATTAGA TAAGTATAAG AATGCAGTAA CAGAATTACA 5940

GCTACTTATG CAAAACACAC CAGCTGTCAA CAACCGGGCC AGAAGAGAAG CACCACAGTA 6000

TATGAACTAC ACAATCAATA CCACTAAAAA CCTAAATGTA TCAATAAGCA AGAAGAGGAA 6060

ACGAAGATTT CTAGGCTTCT TGTTAGGTGT GGGATCTGCA ATAGCAAGTG GTATAGCTGT 6120

ATGAAAAGTT CTACACCTTG AAGGAGAAGT GAACAAGATC AAAAATGCTT TGTTGTCTAC 6180 AAACAAAGCT GTAGTCAGTT TATCAAATGG GGTGAGTGTT TTAACCAGCA AAGTGTTAGA 6240

TCTCAAGAAT TACATAAATA ACCAATTATT ACCCATAGTA AATCAACAGA GCTGTCGCAT 6300

CTCCAACATT GAAACAGTTA TAGAATTCCA GCAGAAGAAC AGCAGATTGT TGGAAATCAC 6360

CAGAGAATTT AGTGTCAATG CAGGTGTAAC AACACCTTTA AGCACTTACA TGTTGACAAA 6420

CAGTGAGTTA CTATCATTAA TGAATGATAT GCCTATAACA AATGATCAGA AAAAATTAAT 6480

GTCAAGCAAT GTTCAGATAG TAAGGCAACA AAGTTATTCC ATCATGTCTA TAATAAAGGA 6540

AGAAGTCCTT GCATATGTTG TACAGCTGCC TATCTATGGT GTAATAGATA CACCTTGCTG 6600

GAAATTGCAC ACATCGCCTC TATGCACTAC CAACATCAAA GAAGGATCAA ATATTTGTTT 6660

AACAAGGACT GATAGAGGAT GGTATTGTGA TAATGCAGGA TCAGTATCCT TCTTTCCACA 6720

GGCTGACACT TGTAAAGTAC AGTCCAATCG AGTATTTTGT GACACTATGA ACAGTTTGAC 6780

ATTACCAAGT GAAGTCAGCC TTTGTAACAC TGACATATTC AATTCCAAGT ATGACTGCAA 6840

AATTATGACA TCAAAAACAG ACATAAGCAG CTCAGTAATT ACTTCTCTTG GAGCTATAGT 6900

GTCATGCTAT GGTAAAACTA AATGCACTGC ATCCAACAAA AATCGTGGGA TTATAAAGAC 6960

ATTTTCTAAT GGTTGTGACT ATGTGTCAAA CAAAGGAGTA GATACTGTGT CAGTGGGCAA 7020

CACTTTATAC TATGTAAACA AGCTGGAAGG CAAGAACCTT TATGTAAAAG GGGAACCTAT 7080

AATAAATTAC TATGACCCTC TAGTGTTTCC TTCTGATGAG TTTGATGCAT CAATATCTCA 7140

AGTCAATGAA AAAATCAATC AAAGTTTAGC TTTTATTCGT AGATCTGATG AATTACTACA 7200

TAATGTAAAT ACTGGCAAAT CTACTAGAAA TATTATGATA ACTACAATTA TTATAGTAAT 7260

CATTGTAGTA TTGTTATCAT TAATAGCTAT TGGTTTACTG TTGTATTGTA AAGCCAAAAA 7320

CACACCAGTT ACACTAAGCA AAGACCAACT AAGTGGAATC AATAATATTG CATTCAGCAA 7380

ATAGACAAAA AACCACCTGA TCATGTTTCA ACAACAATCT GCTGACCACC AATCCCAAAT 7440

CAACTTACAA CAAATATTTC AACATCACAG TACAGGCTGA ATCATTTCCT CACATCATGC 7500

TACCCACATA ACTAAGCTAG ATCCTTAACT TATAGTTACA TAAAAACCTC AAGTATCACA 7560

ATCAACCACT AAATCAACAC ATCATTCACA AAATTAACAG CTGGGGCAAA TATGTCGCGA 7620

AGAAATCCTT GTAAATTTGA GATTAGAGGT CATTGCTTGA ATGGTAGAAG ATGTCACTAC 7680

AGTCATAATT ACTTTGAATG GCCTCCTCAT GCATTACTAG TGAGGCAAAA CTTCATGTTA 7740 AACAAGATAC TCAAGTCAAT GGACAAAAGC ATAGACACTT TGTCTGAAAT AAGTGGAGCT 7800

GCTGAACTGG ATAGAACAGA AGAATATGCT CTTGGTATAG TTGGAGTGCT AGAGAGTTAC 7860

ATAGGATCTA TAAACAACAT AACAAAACAA TCAGCATGTG TTGCTATGAG TAAACTTCTT 7920

ATTGAGATCA ATAGTGATGA CATTAAAAAG CTTAGAGATA ATGAAGAACC CAATTCACCT 7980

AAGATAAGAG TGTACAATAC TGTTATATCA TACATTGAGA GCAATAGAAA AAACAACAAG 8040

CAAACCATCC ATCTGCTCAA GAGACTACCA GCAGACGTGC TGAAGAAGAC AATAAAGAAC 8100

ACATTAGATA TCCACAAAAG CATAACCATA AGCAATCCAA AAGAGTCAAC TGTGAATGAT 8160

CAAAATGACC AAACCAAAAA TAATGATATT ACCGGATAAA TATCCTTGTA GTATATCATC 8220

CATATTGATC TCAAGTGAAA GCATGGTTGC TAGATTCAAT CATAAAAACA TATTACAATT 8280

TAACCATAAC TATTTGGATA ACCACCAGCG TTTATTAAAT CATATATTTG ATGAAATTCA 8340

TTGGACACCT AAAAACTTAT TAGATGCCAC TCAACAATTT CTCCAACATC TTAACATCCC 8400

TGAAGATATA TATACAGTAT ATATATTAGT GTCATAATGC TTGACCATAA CGACTCTATG 8460

TCATCCAACC ATAAAACTAT TTTGATAAGG TTATGGGACA AAATGGATCC CATTATTAAT 8520

GGAAACTCTG CTAATGTGTA TCTAACTGAT AGTTATTTAA AAGGTGTTAT CTCTTTTTCA 8580

GAGTGTAATG CTTTAGGGAG TTATCTTTTT AACGGCCCTT ATCTTAAAAA TGATTACACC 8640

AACTTAATTA GTAGACAAAG CCCACTACTA GAGCATATGA ATCTTAAAAA ACTAACTATA 8700

ACACAGTCAT TAATATCTAG ATATCATAAA GGTGAACTGA AATTAGAAGA ACCAACTTAT 8760

TTCCAGTCAT TACTTATGAC ATATAAAAGT ATGTCCTCGT CTGAACAAAT TGCTACAACT 8820

AACTTACTTA AAAAAATAAT ACGAAGAGCC ATAGAAATAA GTGATGTAAA GGTGTACGCC 8880

ATCTTGAATA AACTAGGATT AAAGGAAAAG GACAGAGTTA AGCCCAACAA TAATTCAGGT 8940

GATGAAAACT CAGTACTTAC AACCATAATT AAAGATGATA TACTTTCGGC TGTGGAAAAC 9000

AATCAATCAT ATACAAATTC AGACAAAAGT CACTCAGTAA ATCAAAATAT CACTATCAAA 9060

ACAACACTCT TGAAAAAATT GATGTGTTCA ATGCAACATC CTCCATCATG GTTAATACAC 9120

TGGTTCAATT TATATACAAA ATTAAATAAC ATATTAACAC AATATCGATC AAATGAGGTA 9180

AAAAGTCATG GGTTTATATT AATAGATAAT CAAACTTTAA GTGGTTTTCA GTTTATTTTA 9240

AATCAATATG GTTGTATCGT TTATCATAAA GGACTCAAAA AAATCACAAC TACTACTTAC 9300 AATCAATTTT TGACATGGAA AGACATCAGC CTTAGCAGAT TAAATGTTTG CTTAATTACT 9360

TGGATAAGTA ATTGTTTAAA TACATTAAAC AAAAGCTTAG GGCTGAGATG TGGATTCAAT 9420

AATGTTGTGT TATCACAATT ATTTCTTTAT GGAGATTGTA TACTGAAATT ATTTCATAAT 9480

GAAGGCTTCT ACATAATAAA AGAAGTAGAG GGATTTATTA TGTCTTTAAT TCTAAACATA 9540

ACAGAAGAAG ATCAATTTAA GAAACGATTT TATAATAGCA TGCTAAATAA CATCACAGAT 9600

GCAGCTATTA AGGCTCAAAA GGACCTACTA TCAAGAGTAT GTCACACTTT ATTAGACAAG 9660

ACAGTGTCTG ATAATATCAT AAATGGTAAA TGGATAATCC TATTAAGTAA ATTTCTTAAA 9720

TTGATTAAGC TTGCAGGTGA TAATAATCTC AATAACTTGA GTGAGCTATA TTTTCTCTTC 9780

AGAATCTTTG GACATCCAAT GGTCGATGAA AGACAAGCAA TGGATTCTGT AAGAATTAAC 9840

TGTAATGAAA CTAAGTTCTA CTTATTAAGT AGTCTAAGTA CATTAAGAGG TGCTTTCATT 9900

TATAGAATCA TAAAAGGGTT TGTAAATACC TACAACAGAT GGCCCACCTT AAGGAATGCT 9960

ATTGTCCTAC CTCTAAGATG GTTAAACTAC TATAAACTTA ATACTTATCC ATCTCTACTT 10020

GAAATCACAG AAAATGATTT GATTATTTTA TCAGGATTGC GGTTCTATCG TGAGTTTCAT 10080

CTGCCTAAAA AAGTGGATCT TGAAATGATA ATAAATGACA AAGCCATTTC ACCTCCAAAA 10140

GATCTAATAT GGACTAGTTT TCCTAGAAAT TACATGCCAT CACATATACA AAATTATATA 10200

GAACATGAAA AGTTGAAGTT CTCTGAAAGC GACAGATCGA GAAGAGTACT AGAGTATTAC 10260

TTGAGAGATA ATAAATTCAA TGAATGCGAT CTATACAATT GTGTAGTCAA TCAAAGCTAT 10320

CTCAACAACT CTAATCACGT GGTATCACTA ACTGGTAAAG AAAGAGAGCT CAGTGTAGGT 10380

AGAATGTTTG CTATGCAACC AGGTATGTTT AGGCAAATCC AAATCTTAGC AGAGAAAATG 10440

ATAGCTGAAA ATATTTTACA ATTCTTCCCT GAGAGTTTGA CAAGATATGG TGATCTAGAG 10500

CTTCAAAAGA TATTAGAATT AAAAGCAGGA ATAAGCAACA AGTCAAATCG TTATAATGAT 10560

AACTACAACA ATTATATCAG TAAATGTTCT ATCATTACAG ATCTTAGCAA ATTCAATCAG 10620

GCATTTAGAT ATGAAACATC ATGTATCTGC AGTGATGTAT TAGATGAACT GCATGGAGTA 10680

CAATCTCTGT TCTCTTGGTT GCATTTAACA ATACCTCTTG TCACAATAAT ATGTACATAT 10740

AGACATGCAC CTCCTTTCAT AAAGGATCAT GTTGTTAATC TTAATGAGGT TGATGAACAA 10800

AGTGGATTAT ACAGATATCA TATGGGTGGT ATTGAGGGCT GGTGTCAAAA ACTGTGGACC 10860 GAATTCATGG AAGAACTGAG TACTGGAACA CTTGGACTGT CATATGAAAA AGCCAAAAAG 12480

TTGTTTCCAC AATATCTAAG TGTCAATTAT TTACACCGTT TAACAGTCAG TAGTAGACCA 12540

TGTGAATTCC CTGCATCAAT ACCAGCTTAT AGAACAACAA ATTATCATTT TGATACTAGT 12600

CCTATCAATC ATGTATTAAC AGAAAAGTAT GGAGATGAAG ATATCGACAT TGTGTTTCAA 1 660

AATTGCATAA GTTTTGGTCT TAGCCTGATG TCGGTTGTGG AACAATTCAC AAACATATGT 12720

CCTAATAGAA TTATTCTCAT ACCGAAGCTG AATGAGATAC ATTTGATGAA ACCTCCTATA 12780

TTTACAGGAG ATGTTGATAT CATCAAGTTG AAGCAAGTGA TACAAAAGCA GCACATGTTC 12840

CTACCAGATA AAATAAGTTT AACCCAATAT GTAGAATTAT TCTTAAGTAA CAAAGCACTT 1 900

AAATCTGGAT CTCACATCAA CTCTAATTTA ATATTAGTAC ATAAAATGTC TGATTATTTT 12960

CATAATGCTT ATATTTTAAG TACTAATTTA GCTGGACATT GGATTCTGAT TATTCAACTT 13020

ATGAAAGATT CAAAAGGTAT TTTTGAAAAA GATTGGGGAG AGGGGTACAT AACTGATCAT 13080

ATGTTCATTA ATTTGAATGT TTTCTTTAAT GCTTATAAGA CTTATTTGCT ATGTTTTCAT 13140

AAAGGTTATG GTAAAGCAAA ATTAGAATGT GATATGAACA CTTCAGATCT TCTTTGTGTT 13200

TTGGAGTTAA TAGACAGTAG CTACTGGAAA TCTATGTCTA AAGTTTTCCT AGAACAAAAA 13260

GTCATAAAAT ACATAGTCAA TCAAGACACA AGTTTGCGTA GAATAAAAGG CTGTCACAGT 13320

TTTAAGTTGT GGTTTTTAAA ACGCCTTAAT AATGCTAAAT TTACCGTATG CCCTTGGGTT 13380

GTTAACATAG ATTATCACCC AACACACATG AAAGCTATAT TATCTTACAT AGATTTAGTT 13440

AGAATGGGGT TAATAAATGT AGATAAATTA ACCATTAAAA ATAAAAACAA ATTCAATGAT 13500

GAATTTTACA CATCAAATCT CTTTTACATT AGTTATAACT TTTCAGACAA CACTCATTTG 13560

CTAACAAAAC AAATAAGAAT TGCTAATTCA GAATTAGAAG ATAATTATAA CAAACTATAT 13620

CACCGAACCC CAGAAACTTT AGAAAATATG TCATTAATTC CTGTTAAAAG TAATAATAGT 13680

AACAAACCTA AATTTTGTAT AAGTGGAAAT ACCGAATCTA TGATGATGTC AACATTCTCT 13740

AGTAAAATGC ATATTAAATC TTCCACTGTT ACCACAAGAT TCAATTATAG CAAACAAGAC 13800

TTGTACAATT TATTTCCAAT TGTTGTGATA GACAAGATTA TAGATCATTC AGGTAATACA 13860

GCAAAATCTA ACCAACTTTA CACCACCACT TCACATGAGA CATCTTTAGT AAGGAATAGT 13920

GCATCACTTT ATTGCATGCT TCCTTGGCAT CATGTCAATA GATTTAACTT TGTATTTAGT 13980 TCCACAGGAT GCAAGATCAG TATAGAGTAT ATTTTAAAAG ATCTTAAGAT TAAGGACCCC 14040

AGTTGTATAG CATTCATAGG TGAAGGAGCT GGTAACTTAT TATTACGTAC GGTAGTAGAA 14100

CTTCATCCAG ACATAAGATA CATTTACAGA AGTTTAAAAG ATTGCAATGA TCATAGTTTA 14160

CCTATTGAAT TTCTAAGGTT ATACAACGGG CATATAAACA TAGATTATGG TGAGAATTTA 14220

ACCATTCCTG CTACAGATGC AACTAATAAC ATTCATTGGT CTTATTTACA TATAAAATTT 14280

GCAGAACCTA TTAGCATCTT TGTCTGCGAT GCTGAATTAC CTGTTACAGC CAATTGGAGT 14340

AAAATTATAA TTGAATGGAG TAAGCATGTA AGAAAGTGCA AGTACTGTTC TTCTGTAAAT 14400

AGATGCATTT TAATTGCAAA ATATCATGCT CAAGATGACA TTGATTTCAA ATTAGATAAC 14460

ATTACTATAT TAAAAACTTA CGTGTGCCTA GGTAGCAAGT TAAAAGGATC TGAAGTTTAC 14520

TTAATCCTTA CAATAGGCCC TGCAAATATA CTTCCTGTTT TTGATGTTGT ACAAAATGCT 14580

AAATTGATAC TTTCAAGAAC TAAAAATTTC ATTATGCCTA AAAAAACTGA CAAGGAATCT 14640

ATCGATGCAA ATATTAAAAG CTTAATACCT TTCCTTTGTT ACCCTATAAC AAAAAAAGGA 14700

ATTAAGACTT CATTGTCAAA ATTGAAGAGT GTAGTTAATG GAGATATATT ATCATATTCT 14760

ATAGCTOGAC GTAATGAAGT ATTCAGCAAC AAGCTTATAA ACCACAAGCA TATGAATATC 14820

CTAAAATGGC TAGATCATQT TTTAAATTTT AGATCAGCTG AACTTAATTA CAATGATTTA 14880

TACATGATAG AGTCCACATA TCCTTACTTA AGTGAATTGT TAAATAGTTT AACAACCAAT 14940

GAGCTCAAGA AGCTGATTAA AATAACAGGT AGTGTGCTAT ACAACCTTCC CAACGAACAG 15000

TAGTTTAAAA TATCATTAAC AAGTTTGGTC AAATTTAGAT GCTAACACAT CATTATATTA 15060

TAGTTATTAA AGAATATACA AACTTTTCAA TAATTTAGCA TATTGATTCC AAAATTATCA 15120

TTTTAGTCTT AAGGGGTTAA ATAAAAGTCT AAAACTAACA ATTATACATG TGCATTCACA 15180

ACACAACGAG ACATTAGTTT TTQACACTTT TTTTCTCGT 15219 (2) INFORMATION FOR SEQ ID NO: 32:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 32:

Met Asp Pro He He Asn Gly Asn Ser Ala Asn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lys Gly Val He Ser Phe Ser Glu Cys Asn Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Asn Gly Pro Tyr Leu Lys Aβn Aβp Tyr Thr Aβn Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu Hiβ Met Aβn Leu Lys Lys Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr His Lys Gly Glu Leu Lys 65 70 75 80

Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lys He 100 105 110

He Arg Arg Ala He Glu He Ser Asp Val Lys Val Tyr Ala He Leu 115 120 125

Aβn Lye Leu Gly Leu Lye Glu Lys Asp Arg Val Lys Pro Asn Asn Asn 130 135 140

Ser Gly Aβp Glu Asn Ser Val Leu Thr Thr He He Lys Asp Asp He 145 150 155 160

Leu Ser Ala Val Glu Aβn Aβn Gin Ser Tyr Thr Aβn Ser Aβp Lys Ser 165 170 175

His Ser Val Asn Gin Asn He Thr He Lys Thr Thr Leu Leu Lys Lys 180 185 190

Leu Met Cys Ser Met Gin His Pro Pro Ser Trp Leu He His Trp Phe 195 200 205

Asn Leu Tyr Thr Lye Leu Aβn Aβn He Leu Thr Gin Tyr Arg Ser Aβn 210 215 220

Glu Val Lye Ser Hie Gly Phe He Leu He Aβp Aβn Gin Thr Leu Ser 225 230 235 240

Gly Phe Gin Phe He Leu Aβn Gin Tyr Gly Cys He Val Tyr His Lys 245 250 255

Gly Leu Lys Lys He Thr Thr Thr Thr Tyr Asn Gin Phe Leu Thr Trp 260 265 270

Lye Asp He Ser Leu Ser Arg Leu Asn Val Cys Leu He Thr Trp He 275 280 285

Ser Asn Cys Leu Asn Thr Leu Asn Lye Ser Leu Gly Leu Arg Cye Gly 290 295 300

Phe Asn Aβn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Aβp Cys He 305 310 315 320

Leu Lys Leu Phe His Aβn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Asn He Thr Glu Glu Asp Gin Phe 340 345 350

Lye Lys Arg Phe Tyr Aen Ser Met Leu Aβn Asn He Thr Asp Ala Ala 355 360 365

He Lys Ala Gin Lys Asp Leu Leu Ser Arg Val Cys His Thr Leu Leu 370 375 380

Aβp Lye Thr Val Ser Aβp Aβn He He Aβn Gly Lys Trp He He Leu 385 390 395 400

Leu Ser Lys Phe Leu Lye Leu He Lys Leu Ala Gly Asp Asn Asn Leu 405 410 415

Asn Asn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly His Pro 420 425 430

Met Val Asp Glu Arg Gin Ala Met Asp Ser Val Arg He Aβn Cyβ Asn 435 440 445

Glu Thr Lys Phe Tyr Leu Leu Ser Ser Leu Ser Thr Leu Arg Gly Ala 450 455 460

Phe He Tyr Arg He He Lys Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Aen Tyr 485 490 495

Tyr Lye Leu Aen Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Aβn Aβp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe His Leu Pro 515 520 525 Lys Lys Val Asp Leu Glu Met He He Aβn Asp Lys Ala He Ser Pro 530 535 540

Pro Lys Asp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

Hiβ He Gin Asn Tyr He Glu His Glu Lys Leu Lys Phe Ser Glu Ser 565 570 575

Asp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Asp Aβn Lys Phe 580 585 590

Aβn Glu Cyβ Aβp Leu Tyr Aβn Cye Val Val Aβn Gin Ser Tyr Leu Aβn 595 600 605

Asn Ser Asn His Val Val Ser Leu Thr Gly Lys Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lys Met He Ala Glu Aβn He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Asp Leu Glu Leu Gin Lys He Leu Glu 660 665 670

Leu Lys Ala Gly He Ser Asn Lys Ser Asn Arg Tyr Asn Asp Asn Tyr 675 680 685

Asn Asn Tyr He Ser Lys Cys Ser He He Thr Asp Leu Ser Lys Phe 690 695 700

Asn Gin Ala Phe Arg Tyr Glu Thr Ser Cys He Cys Ser Asp Val Leu 705 710 715 720

Asp Glu Leu Hiβ Gly Val Gin Ser Leu Phe Ser Trp Leu Hiβ Leu Thr 725 730 735

He Pro Leu Val Thr He He Cys Thr Tyr Arg His Ala Pro Pro Phe 740 745 750

He Lys Aβp His Val Val Asn Leu Asn Glu Val Asp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr Hiβ Met Gly Gly He Glu Gly Trp Cys Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Asp Leu He Ser Leu Lys Gly 785 790 795 800 Lye Phe Ser He Thr Ala Leu He Aβn Gly Aβp Aβn Gin Ser He Aβp 805 810 815

He Ser Lye Pro Val Arg Leu He Glu Gly Gin Thr Hiβ Ala Gin Ala 820 825 830

Aβp Tyr Leu Leu Ala Leu Aβn Ser Leu Lys Leu Leu Tyr Lys Glu Tyr 835 840 845

Ala Gly He Gly Hiβ Lye Leu Lye Gly Thr Glu Thr Tyr He Ser Arg 850 855 860

Aβp Met Gin Phe Met Ser Lye Thr He Gin Hiβ Aβn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lye Lye Val Leu Arg Val Gly Pro Trp He Asn Thr 885 890 895

He Leu Asp Asp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910

Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cyβ Ser Leu He Phe 915 920 925

Arg Aβn He Trp Leu Tyr Aβn Gin He Ala Leu Gin Leu Arg Asn His 930 935 940

Ala Leu Cys Aβn Aβn Lys Leu Tyr Leu Asp He Leu Lys Val Leu Lys 945 950 955 960

Hiβ Leu Lye Thr Phe Phe Asn Leu Asp Ser He Aβp Met Ala Leu Ser 965 970 975

Leu Tyr Met Aβn Leu Pro Met Leu Phe Gly Gly Gly Aβp Pro Aβn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Aβp Phe Leu Thr Glu Ala 995 1000 1005

He Val Hiβ Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly His Asp Leu 1010 1015 1020

Gin Asp Lye Leu Gin Asp Leu Pro Asp Asp Arg Leu Asn Lys Phe Leu 1025 1030 1035 1040

Thr Cys Val He Thr Phe Asp Lys Asn Pro Asn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Aβp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lys He 1060 1065 1070

Thr Ser Glu He Asn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Asn Lys He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Aβn Aβp He Met Gin Aβn He Glu Pro Thr Tyr Pro Hiβ 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lys Ala Glu Lys 1125 1130 1135

He Val Asn Leu He Ser Gly Thr Lys Ser He Thr Aβn He Leu Glu 1140 1145 1150

Lye Thr Ser Ala He Aep Thr Thr Aβp He Aβn Arg Ala Thr Aβp Met 1155 1160 1165

Met Arg Lye Aβn He Thr Leu Leu He Arg He Leu Pro Leu Asp Cys 1170 1175 1180

Aβn Lye Aep Lye Arg Glu Leu Leu Ser Leu Glu Asn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lys Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Asn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asn He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Asn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lys Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lys Lys Thr Met Pro Val Tyr Asn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lys Lys Gin Arg Asp Gin He Asp Leu Leu Ala Lys Leu Asp 1285 1290 1295

Trp Val Tyr Ala Ser He Asp Asn Lys Aβp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lys Ala Lys Lys Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Asn Tyr Leu His Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cys Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Aβn 1345 1350 1355 1360 Tyr His Phe Asp Thr Ser Pro He Asn His Val Leu Thr Glu Lys Tyr 1365 1370 1375

Gly Asp Glu Aβp He Aβp He Val Phe Gin Aβn Cyβ He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Aβn He Cyβ Pro Aβn 1395 1400 1405

Arg He He Leu He Pro Lye Leu Aβn Glu He His Leu Met Lys Pro 1410 1415 1420

Pro He Phe Thr Gly Aβp Val Aβp He He Lye Leu Lye Gin Val He 1425 1430 1435 1440

Gin Lys Gin His Met Phe Leu Pro Asp Lys He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Aβn Lye Ala Leu Lys Ser Gly Ser His He 1460 1465 1470

Asn Ser Aβn Leu He Leu Val Hiβ Lye Met Ser Aβp Tyr Phe His Aβn 1475 1480 1485

Ala Tyr He Leu Ser Thr Aβn Leu Ala Gly Hiβ Trp He Leu He He 1490 1495 1500

Gin Leu Met Lye Aβp Ser Lye Gly He Phe Glu Lye Aβp Trp Gly Glu 1505 1510 1515 1520

Gly Tyr He Thr Aβp Hiβ Met Phe He Aβn Leu Aen Val Phe Phe Aβn 1525 1530 1535

Ala Tyr Lye Thr Tyr Leu Leu Cys Phe His Lys Gly Tyr Gly Lys Ala 1540 1545 1550

Lye Leu Glu Cyβ Aβp Met Aβn Thr Ser Asp Leu Leu Cys Val Leu Glu 1555 1560 1565

Leu He Asp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580

Gin Lys Val He Lys Tyr He Val Asn Gin Asp Thr Ser Leu Arg Arg 1585 1590 1595 1600

He Lys Gly Cys His Ser Phe Lys Leu Trp Phe Leu Lys Arg Leu Asn 1605 1610 1615

Asn Ala Lys Phe Thr Val Cys Pro Trp Val Val Asn He Asp Tyr His 1620 1625 1630 Pro Thr His Met Lye Ala He Leu Ser Tyr He Aβp Leu Val Arg Met 1635 1640 1645

Gly Leu He Aβn Val Aβp Lye Leu Thr He Lye Aβn Lye Asn Lys Phe 1650 1655 1660

Aβn Asp Glu Phe Tyr Thr Ser Asn Leu Phe Tyr He Ser Tyr Asn Phe 1665 1670 1675 1680

Ser Asp Asn Thr His Leu Leu Thr Lys Gin He Arg He Ala Aβn Ser 1685 1690 1695

Glu Leu Glu Asp Asn Tyr Asn Lys Leu Tyr His Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Asn Met Ser Leu He Pro Val Lys Ser Asn Asn Ser Asn Lys 1715 1720 1725

Pro Lys Phe Cyβ He Ser Gly Aβn Thr Glu Ser Met Met Met Ser Thr 1730 1735 1740

Phe Ser Ser Lye Met Hie He Lye Ser Ser Thr Val Thr Thr Arg Phe 1745 1750 1755 1760

Asn Tyr Ser Lys Gin Aβp Leu Tyr Aβn Leu Phe Pro He Val Val He 1765 1770 1775

Aβp Lye He He Aβp Hiβ Ser Gly Aβn Thr Ala Lye Ser Asn Gin Leu 1780 1785 1790

Tyr Thr Thr Thr Ser His Gin Thr Ser Leu Val Arg Asn Ser Ala Ser 1795 1800 1805

Leu Tyr Cys Met Leu Pro Trp His His Val Asn Arg Phe Asn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cys Lys He Ser He Glu Tyr He Leu Lys Aβp 1825 1830 1835 1840

Leu Lye He Lye Aβp Pro Ser Cyβ He Ala Phe He Gly Glu Gly Ala 1845 1850 1855

Gly Asn Leu Leu Leu Arg Thr Val Val Glu Leu His Pro Aβp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lys Asp Cys Asn Aβp Hiβ Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Aβn Gly His He Asn He Asp Tyr Gly Glu 1890 1895 1900

Asn Leu Thr He Pro Ala Thr Asp Ala Thr Asn Asn He Hiβ Trp Ser 1905 1910 1915 1920

Tyr Leu His He Lys Phe Ala Glu Pro He Ser He Phe Val Cys Asp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Asn Trp Ser Lys He He He Glu Trp 1940 1945 1950

Ser Lys His Val Arg Lys Cys Lys Tyr Cys Ser Ser Val Aβn Arg Cyβ 1955 1960 1965

He Leu He Ala Lys Tyr His Ala Gin Aβp Aβp He Aβp Phe Lye Leu 1970 1975 1980

Aep Aβn He Thr He Leu Lye Thr Tyr Val Cyβ Leu Gly Ser Lye Leu 1985 1990 1995 2000

Lye Gly Ser Glu Val Tyr Leu He Leu Thr He Gly Pro Ala Aβn He 2005 2010 2015

Leu Pro Val Phe Aβp Val Val Gin Asn Ala Lys Leu He Leu Ser Arg 2020 2025 2030

Thr Lys Asn Phe He Met Pro Lys Lys Thr Asp Lys Glu Ser He Asp 2035 2040 2045

Ala Asn He Lys Ser Leu He Pro Phe Leu Cys Tyr Pro He Thr Lys 2050 2055 2060

Lys Gly He Lys Thr Ser Leu Ser Lys Leu Lye Ser Val Val Aβn Gly 2065 2070 2075 2080

Aβp He Leu Ser Tyr Ser He Ala Gly Arg Aβn Glu Val Phe Ser Aβn 2085 2090 2095

Lys Leu He Asn Hiβ Lye Hiβ Met Aβn He Leu Lys Trp Leu Asp His 2100 2105 2110

Val Leu Asn Phe Arg Ser Ala Glu Leu Asn Tyr Asn His Leu Tyr Met 2115 2120 2125

He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Asn Ser Leu Thr 2130 2135 2140

Thr Asn Glu Leu Lys Lys Leu He Lys He Thr Gly Ser Val Leu Iyr 2145 2150 2155 2160

Asn Leu Pro Asn Glu Gin 2165

(2) INFORMATION FOR SEQ ID NO: 33: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 15219 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:33:

ACGGGAAAAA AATGCCTACT ACAAACTTGC ACATTCGAAA AAAATGGGGC AAATAAGAAC 60

TTGATAAGTG CTATTTAAGT CTAACCTTTT CAATCAGAAA TGGGGTGCAA TTCACTGAGC 120

ATGATAAAGG TTAGATTACA AAATTTATTT GACAATGACG AAGTAGCATT GTTAAAAATA 180

ACATGTTATA CTGATAAATT AATTCTTCTG ACCAATGCAT TAGCCAAAGC AGCAATACAT 240

ACAATTAAAT TAAACGGCAT AGTTTTTATA CATGTTATAA CAAGCAGTGA AGTGTGCCCT 300

GATAACAATA TTGTAGTGAA ATCTAACTTT ACAACAATGC CAATACTACA AAATGGAGGA 360

TACATATGGG AATTGATTGA GTTGACACAC TGCTCTCAAT TAAACGGTTT AATGGATGAT 420

AATTGTGAAA TCAAATTTTC TAAAAGACTA AGTGACTCAG TAATGACTAA TTATATGAAT 480

CAAATATCTG ACTTACTTGG GCTTGATCTC AATTCATGAA TTATGTTTAG TCTAATTCAA 540

TAGACATGTG TTTATTACCA TTTTAGTTAA TATAAAAACT CATCAAAGGG AAATGGGGCA 600

AATAAACTCA CCTAATCAAT CAAACCATGA GCACTACAAA TGACAACACT ACTATGCAAA 660

GATTGATGAT CACAGACATG AGACCCCTGT CAATGGATTC AATAATAACA TCTCTTACCA 720

AAGAAATCAT CACACACAAA TTCATATACT TGATAAACAA TGAATGTATT GTAAGAAAAC 780

TTGATGAAAG ACAAGCTACA TTTACATTCT TAGTCAATTA TGAGATGAAG CTACTGCACA 840

AAGTAGGGAG TACCAAATAC AAAAAATACA CTGAATATAA TACAAAATAT GGCACTTTCC 900

CCATGCCTAT ATTTATCAAT CACGGCGGGT TTCTAGAATG TATTGGCATT AAGCCTACAA 960

AACACACTCC TATAATATAC AAATATGACC TCAACCCGTG AATTCCAACA AAAAAACCAA 1020

CCCAACCAAA CCAAACTATT CCTCAAACAA CAGTGCTCAA TAGTTAAGAA GGAGCTAATC 1080

CATTTTAGTA ATTAAAAATA AAAGTAAAGC CAATAACATA AATTGGGGCA AATACAAAGA 1140

TGGCTCTTAG CAAAGTCAAG TTGAATGATA CATTAAATAA GGATCAGCTG CTGTCATCCA 1200 GCAAATACAC TATTCAACGT AGTACAGGAG ATAATATTGA CACTCCCAAT TATGATGTGC 1260

AAAAACACCT AAACAAACTA TGTGGTATGC TATTAATCAC TGAAGATGCA AATCATAAAT 1320

TCACAGGATT AATAGGTATG TTATATGCTA TGTCCAGGTT AGGAAGGGAA GACACTATAA 1380

AGATACTTAA AGATGCTGGA TATCATGTTA AAGCTAATGG AGTAGATATA ACAACATATC 1440

GTCAAGATAT AAATGGAAAG GAAATGAAAT TCGAAGTATT AACATTATCA AGCTTGACAT 1500

CAGAAATACA AGTCAATATT GAGATAGAAT CTAGAAAGTC CTACAAAAAA ATGCTAAAAG 1560

AGATGGGAGA AGTGGCTCCA GAATATAGGC ATGATTCTCC AGACTGTGGG ATGATAATAC 1620

TGTGTATAGC TGCACTTGTG ATAACCAAAT TAGCAGCAGG AGACAGATCA GGTCTTACAG 1680

CAGTAATTAG GAGGGCAAAC AATGTCTTAA AAAACGAAAT AAAACGATAC AAGGGCCTCA 1740

TACCAAAGGA TATAGCTAAC AGTTTTTATG AAGTGTTTGA AAAACACCCT CATCTTATAG 1800

ATGTTTTCGT GCACTTTGGC ATTGCACAAT GATCCACAAG AGGGGGTAGT AGAGTTGAAG 1860

GAATCTTTGC AGGATTGTTT ATGAATGCCT ATGGTTCAGG GCAAGTAATG CTAAGATGGG 1920

GAGTTTTAGC CAAATCTGTA AAAAATATCA TGCTAGGACA TGCTAGTGTC CAGGCAGAAA 1980

TGGAGCAAGT TGTGGAAGTC TATGAGTATG CACAGAAGTT GGGAGGAGAA GCTGGATTCT 2040

ACCATATATT GAACAATCCA AAAGCATCAT TGCTGTCATT AACTCAATTT CCCAACTTCT 2100

CAAGTGTGGT CCTAGGCAAT GCAGCAGGTC TAGGCATAAT GGGAGAGTAT AGAGGTACAC 2160

CAAGAAACCA GGATCTTTAT GATGCAGCTA AAGCATATGC AGAGCAACTC AAAGAAAATG 2220

GAGTAATAAA CTAGAGTGTA TTAGACTTAA CAGCAGAAGA ATTGGAAGCC ATAAAGCATC 2280

AACTCAACCC CAAAGAAGAT GATGTAGAGC TTTAAGTTAA CAAAAAATAC GGGGCAAATA 2340

AGTCAACATG GAGAAGTTTG CACCTGAATT TCATGGAGAA GATGCAAATA ACAAAGCTAC 2400

CAAATTCCTA GAATCAATAA AGGGCAAGTT CGCATCATCC AAAGATCCTA AGAAGAAAGA 2460

TAGCATAATA TCTGTTAACT CAATAGATAT AGAAGTAACT AAAGAGAGCC CGATAACATC 2520

TGGCACCAAC ATCATCAATC CAACAAGTGA AGCCGACAGT ACCCCAGAAA CAAAAGCCAA 2580

CTACCCAAGA AAACCCCTAG TAAGCTTCAA AGAAGATCTC ACCCGAAGTG ACAACCCTTT 2640

TTCTAAGTTG TACAAGGAAA CAATAGAAAC ATTTGATAAC AATGAAGAAG AATCTAGCTA 2700

CTCATATGAA GAGATAAATG ATCAAACAAA TGACAACATT ACAGCAAGAC TAGATAGAAT 2760 TGATGAAAAA TTAAGTGAAA TATTAGGAAT GCTCCATACA TTAGTAGTTG CAAGTGCAGG 2820

ACCCACTTCA GCTCGCGATG GAATAAGAGA TGCTATGGTT GGTCTAAGAG AAGAGATGAT 2880

AGAAAAAATA AGAGCGGAAG CATTAATGAC CAATGATAGG TTAGAGGCTA TGGCAAGACT 2940

TAGGAATGAG GAAAGCGAAA AAATGGCAAA AGACACCTCA GATGAAGTGT CTCTTAATCC 3000

AACTTCCAAA AAATTGAGTG ACTTGTTGGA AGACAACGAT AGTGACAATG ATCTATCACT 3060

TGATGATTTT TGATCAGCGA TCAACTCACT CAGCAATCAA CAACATCAAT AAAACAGACA 3120

TCAATCCATT GAATCAACTG CCAGACCGAA CAAACAAACG TCCATCAGTA GAACCACCAA 3180

CCAATCAATC AACCAATTGA TCAATCAGCA ACCCGACAAA ATTAACAATA TAGTAACAAA 3240

AAAAGAACAA GATGGGGCAA ATATGGAAAC ATACGTGAAC AAGCTTCACG AAGGCTCCAC 3300

ATACACAGCA GCTGTTCAGT ACAATGTTCT AGAAAAAGAT GATGATCCTG CATCACTAAC 3360

AATATGGGTG CCTATGTTCC AGTCATCTGT GCCAGCAGAC TTGCTCATAA AAGAACTTGC 3420

AAGCATCAAT ATACTAGTGA AGCAGATCTC TACGCCCAAA GGACCTTCAC TACGAGTCAC 3480

GATTAACTCA AGAAGTGCTG TGCTGGCTCA AATGCCTAGT AATTTCATCA TAAGCGCAAA 3540

TGTATCATTA GATGAAAGAA GCAAATTAGC ATATGATGTA ACTACACCTT GTGAAATCAA 3600

AGCATGCAGT CTAACATGCT TAAAAGTAAA AAGTATGTTA ACTACAGTCA AAGATCTTAC 3660

CATGAAGACA TTCAACCCCA CTCATGAGAT CATTGCTCTA TGTGAATTTG AAAATATTAT 3720

GACATCAAAA AGAGTAATAA TACCAACCTA TCTAAGATCA ATTAGTGTCA AGAACAAGGA 3780

TCTGAACTCA CTAGAAAATA TAGCAACCAC CGAATTCAAA AATGCTATCA CCAATGCAAA 3840

AATTATTCCT TATGCAGGAT TAGTGTTAGT TATCACAGTT ACTGACAATA AAGGAGCATT 3900

CAAATATATC AAACCACAGA GTCAATTTAT AGTAGATCTT GGTGCCTACC TAGAAAAAGA 3960

GAGCATATAT TATGTGACTA CTAATTGGAA GCATACAGCT ACACGTTTTT CAATCAAACC 4020

ACTAGAGGAT TAAACTTAAT TATCAACACT GAATGACAGG TCCACATATA TCCTCAAACT 4080

ACACACTATA TCCAAACATC ATAAACATCT ACACTACACA CTTCATCACA CAAACCAATC 4140

CGACTCAAAA TCCAAAATCA CTACCAGCCA CTATCTGCTA GACCTAGAGT GCGAATAGGT 4200

AAATAAAACC AAAATATGGG GTAAATAGAC ATTAGTTAGA GTTCAATCAA TCTTAACAAC 4260

CATTTATACC GCCAATTCAA CACATATACT ATAAATCTTA AAATGGGAAA TACATCCATC 4320 ACAATAGAAT TCACAAGCAA ATTTTGGCCC TATTTTACAC TAATACATAT GATCTTAACT 4380

CTAATCTTTT TACTAATTAT AATCACTATT ATGATTGCAA TACTAAATAA GCTAAGTGAA 4440

CATAAAGCAT TCTGTAACAA AACTCTTGAA CTAGGACAGA TGTATCAAAT CAACACATAG 4500

AGTTCTACCA TTATGCTGTG TCAAATTATA ATCCTGTATA TATAAACAAA CAAATCCAAT 4560

CTTCTCACAG AGTCATGGTG TCGCAAAACC ACGCTAACTA TCATGGTAGC ATAGAGTAGT 4620

TATTTAAAAA TTAACATAAT GATGAATTGT TAGTATGAGA TCAAAAACAA CATTGGGGCA 4680

AATGCAACCA TGTCCAAACA CAAGAATCAA CGCACTGCCA GGACTCTAGA AAAGACCTGG 4740

GATACTCTTA ATCATCTAAT TGTAATATCC TCTTGTTTAT ACAGATTAAA TTTAAAATCT 4800

ATAGCACAAA TAGCACTATC AGTTTTGGCA ATGATAATCT CAACCTCTCT CATAATTGCA 4860

GCCATAATAT TCATCATCTC TGCCAATCAC AAAGTTACAC TAACAACGGT CACAGTTCAA 4920

ACAATAAAAA ACCACACTGA AAAAAACATC ACCACCTACC CTACTCAAGT CTCACCAGAA 4980

AGGGTTAGTT CATCCAAGCA ACCCACAACC ACATCACCAA TCCACACAAG TTCAGCTACA 5040

ACATCACCCA ATACAAAATC AGAAACACAC CATAGAACAG GAGAAACCAA AGGCAGAACC 5100

ACCACTTCAA CACAGACCAA CAAGCCAAGC ACAAAACCAC GTCCAAAAAA TCCACCAAAA 5160

AAAGATGATT ACCATTTTGA AGTGTTCAAC TTCGTTCCCT GCAGTATATG TGGCAACAAT 5220

CAACTTTGCA AATCCATCTG CAAAACAATA CCAAGCAACA AACCAAAGAA GAAACCAACC 5280

ATCAAACCCA CAAACAAACC AACCACCAAA ACCACAAACA AAAGAGACCC AAAAACACCA 5340

GCGAAAACGA CGAAAAAAGA AACTACCACC AACCCAACAA AAAAACTAAC CCTCAAGACC 5400

ACAGAAAGAG ACACCAGCAC CTCACAATCC ACTGCACTCG ACACAACCAC ATTAAAACAC 5460

ACAGTCCAAC AGCAATCCCT CCTCTCAACC ACCCCCGAAA ACACACCCAA CTCCACACAA 5520

ACACCCACAG CATCCGAGCC CTCGACACCA AACTCCACCC AAAAAACCCA GCCACATGCT 5580

TAGTTATTCA AAAACTACAT CTTAGCAGAG AACCGTGATC TATCAAGCAA GAACGAAATT 5640

AAACCTGGGG CAAATAACCA TGGAGTTGAT GATCCACAAG TCAAGTGCAA TCTTCCTAAC 5700

TCTTGCTATT AATGCATTGT ACCTGACCTC AAGTCAGAAC ATAACTGAGG AGTTTTACCA 5760

ATCGACATGT AGTGCAGTTA GCAGAGGTTA TTTTAGTGCT TTAAGAACAG GTTGGTATAC 5820

TAGTGTCATA ACAATAGAAT TAAGTAATAT AAAAGAAACC AAATGCAATG GAACTGACAC 5880 TAAAGTAAAA CTTATGAAAC AAGAATTAGA TAAGTATAAG AATGCAGTAA CAGAATTACA 5940

GCTACTTATG CAAAAGACAC CAGCTGTCAA CAACCGGGCC AGAAGAGAAG CACCACAGTA 6000

TATGAACTAC ACAATCAATA CCACTAAAAA CCTAAATGTA TCAATAAGCA AGAAGAGGAA 6060

ACGAAGATTT CTAGGCTTCT TGTTAGGTGT GGGATCTGCA ATAGCAAGTG GTATAGCTGT 6120

ATCAAAAGTT CTACACCTTG AAGGAGAAGT GAACAAGATC AAAAATGCTT TGTTGTCTAC 6180

AAACAAAGCT GTAGTCAGTT TATCAAATGG GGTGAGTGTT TTAACCAGCA AAGTGTTAGA 6240

TCTCAAGAAT TACATAAATA ACCAATTATT ACCCATAGTA AATCAACAGA GCTGTCGCAT 6300

CTCCAACATT GAAACAGTTA TAGAATTCCA GCAGAAGAAC AGCAGATTGT TGGAAATCAC 6360

CAGAGAATTT AGTGTCAATG CAGGTGTAAC AACACCTTTA AGCACTTACA TGTTGACAAA 6420

CAGTGAGTTA CTATCATTAA TCAATGATAT GCCTATAACA AATGATCAGA AAAAATTAAT 6480

GTCAAGCAAT GTTCAGATAG TAAGGCAACA AAGTTATTCC ATCATGTCTA TAATAAAGGA 6540

AGAAGTCCTT GCATATGTTG TACAGCTGCC TATCTATGGT GTAATAGATA CACCTTGCTG 6600

GAAATTGCAC ACATCGCCTC TATGCACTAC CAACATCAAA GAAGGATCAA ATATTTGTTT 6660

AACAAGGACT GATAGAGGAT GGTATTGTGA TAATGCAGGA TCAGTATCCT TCTTTCCACA 6720

GGCTGACACT TGTAAAGTAC AGTCCAATCG AGTATTTTGT GACACTATGA ACAGTTTGAC 6780

ATTACCAAGT GAAGTCAGCC TTTGTAACAC TGACATATTC AATTCCAAGT ATGACTGCAA 6840

AATTATGACA TCAAAAACAG ACATAAGCAG CTCAGTAATT ACTTCTCTTG GAGCTATAGT 6900

GTCATGCTAT GGTAAAACTA AATGCACTGC ATCCAACAAA AATCGTGGGA TTATAAAGAC 6960

ATTTTCTAAT GGTTGTGACT ATGTGTCAAA CAAAGGAGTA GATACTGTGT CAGTGGGCAA 7020

CACTTTATAC TATGTAAACA AGCTGGAAGG CAAGAACCTT TATGTAAAAG GGGAACCTAT 7080

AATAAATTAC TATGACCCTC TAGTGTTTCC TTCTGATGAG TTTGATGCAT CAATATCTCA 7140

AGTCAATGAA AAAATCAATC AAAGTTTAGC TTTTATTCGT AGATCTGATG AATTACTACA 7200

TAATGTAAAT ACTGGCAAAT CTACTACAAA TATTATGATA ACTACAATTA TTATAGTAAT 7260

CATTGTAGTA TTGTTATCAT TAATAGCTAT TGGTTTACTG TTGTATTGTA AAGCCAAAAA 7320

CACACCAGTT ACACTAAGCA AAGACCAACT AAGTGGAATC AATAATATTG CATTCAGCAA 7380

ATAGACAAAA AACCACCTGA TCATGTTTCA AGAACAATCT GCTGACCACC AATCCCAAAT 7440 CAACTTACAA CAAATATTTC AACATCACAG TACAGGCTGA ATCATTTCCT CACATCATGC 7500

TACCCACATA ACTAAGCTAG ATCCTTAACT TATAGTTACA TAAAAACCTC AAGTATCACA 7560

ATCAACCACT AAATCAACAC ATCATTCACA AAATTAACAG CTGGGGCAAA TATGTCGCGA 7620

AGAAATCCTT GTAAATTTGA GATTAGAGGT CATTGCTTGA ATGGTAGAAG ATGTCACTAC 7680

AGTCATAATT ACTTTGAATG GCCTCCTCAT GCATTACTAG TGAGGCAAAA CTTCATGTTA 7740

AACAAGATAC TCAAGTCAAT GGACAAAΛGC ATAGACACTT TGTCTGAAAT AAGTGGAGCT 7800

GCTGAACTGG ATAGAACAGA AGAATATGCT CTTGGTATAG TTGGAGTGCT AGAGAGTTAC 7860

ATAGGATCTA TAAAGAAGAT AACAAAACAA TCAGCATGTG TTGCTATGAG TAAACTTCTT 7920

ATTGAGATCA ATAGTGATGA CATTAAAAAG CTTAGAGATA ATGAAGAACC CAATTCACCT 7980

AAGATAAGAG TGTACAATAC TGTTATATCA TACATTGAGA GCAATAGAAA AAACAACAAG 8040

CAAACCATCC ATCTGCTCAA GAGACTACCA GCAGACGTGC TGAAGAAGAC AATAAAGAAC 8100

ACATTAGATA TCCACAAAAG CATAACCATA AGCAATCCAA AAGAGTCAAC TGTGAATGAT 8160

CAAAATGACC AAACCAAAAA TAATGATATT ACCGGATAAA TATCCTTGTA GTATATCATC 8220

CATATTGATC TCAAGTGAAA GCATGGTTGC TACATTCAAT CA AAAAACA TATTACAATT 8280

TAACCATAAC TATTTGGATA ACCACCAGCG TTTATTAAAT CATATATTTG ATGAAATTCA 8340

TTGGACACCT AAAAACTTAT TAGATGCCAC TCAACAATTT CTCCAACATC TTAACATCCC 8400

TGAAGATATA TATACAGTAT ATATATTAGT GTCATAATGC TTGACGATAA CGACTCTATG 8460

TCATCCAACC ATAAAACTAT TTTGATAAGG TTATGGGACA AAATGGATCC CATTATTAAT 8520

GGAAACTCTG CTAATGTGTA TCTAACTGAT AGTTATTTAA AAGGTGTTAT CTCTTTTTCA 8580

GAGTGTAATG CTTTAGGGAG TTATCTTTTT AACGGCCCTT ATCTTAAAAA TGATTACACC 8640

AACTTAATTA GTAGACAAAG CCCACTACTA GAGCATATGA ATCTTAAAAA ACTAACTATA 8700

ACACAGTCAT TAATATCTAG ATATCATAAA GGTGAACTGA AATTAGAAGA ACCAACTTAT 8760

TTCCAGTCAT TACTTATGAC ATATAAAAGT ATGTCCTCGT CTGAACAAAT TGCTACAACT 8820

AACTTACTTA AAAAAATAAT ACGAAGAGCC ATAGAAATAA GTGATGTAAA GGTGTACGCC 8880

ATCTTGAATA AACTAGGATT AAAGGAAAAG GACAGAGTTA AGCCCAACAA TAATTCAGGT 8940

GATGAAAACT CAGTACTTAC AACTATAATT AAAGATGATA TACTTTCGGC TGTGGAAAAC 9000 AATCAATCAT ATACAAATTC AGACAAAAGT CACTCAGTAA ATCAAAATAT CACTATCAAA 9060

ACAACACTCT TGAAAAAATT GATGTGTTCA ATGCAACATC CTCCATCATG GTTAATACAC 9120

TGGTTCAATT TATATACAAA ATTAAATAAC ATATTAACAC AATATCGATC AAATGAGGTA 9180

AAAAGTCATG GGTTTATATT AATAGATAAT CAAACTTTAA GTGGTTTTCA GTTTATTTTA 9240

AATCAATATG GTTGTATCGT TTATCATAAA GGACTCAAAA AAATCACAAC TACTACTTAC 9300

AATCAATTTT TGACATGGAA AGACATCAGC CTTAGCAGAT TAAATGTTTG CTTAATTACT 9360

TGGATAAGTA ATTGTTTAAA TACATTAAAC AAAAGCTTAG GGCTGAGATG TGGATTCAAT 9420

AATGTTGTGT TATCACAATT ATTTCTTTAT GGAGATTGTA TACTGAAATT ATTTCATAAT 9480

GAAGGCTTCT ACATAATAAA AGAAGTAGAG GGATTTATTA TGTCTTTAAT TCTAAACATA 9540

ACAGAAGAAG ATCAATTTAG GAAACGATTT TATAATAGCA TGCTAAATAA CATCACAGAT 9600

GCAGCTATTA AGGCTCAAAA GGACCTACTA TCAAGAGTAT GTCACACTTT ATTAGACAAG 9660

ACAGTGTCTG ATAATATCAT AAATGGTAAA TGGATAATCC TATTAAGTAA ATTTCTTAAA 9720

TTGATTAAGC TTGCAGGTGA TAATAATCTC AATAACTTGA GTGAGCTATA TTTTCTCTTC 9780

AGAATCTTTG GACATCCAAT GGTCGATGAA AGACAAGCAA TGGATTCTGT AAGAATTAAC 9840

TGTAATGAAA CTAAGTTCTA CTTATTAAGT AGTCTAAGTA CATTAAGAGG TGCTTTCATT 9900

TATAGAATCA TAAAAGGGTT TGTAAATACC TACAACAGAT GGCCCACCTT AAGGAATGCT 9960

ATTGTCCTAC CTCTAAGATG GTTAAACTAC TATAAACTTA ATACTTATCC ATCTCTACTT 10020

GAAATCACAG AAAATGATTT GATTATTTTA TCAGGATTGC GGTTCTATCG TGAGTTTCAT 10080

CTGCCTAAAA AAGTGGATCT TGAAATGATA ATAAATGACA AAGCCATTTC ACCTCCAAAA 10140

GATCTAATAT GGACTAGTTT TCCTAGAAAT TACATGCCAT CACATATACA AAATTATATA 10200

GAACATGAAA AGTTGAAGTT CTCTGAAAGC GACAGATCGA GAAGAGTACT AGAGTATTAC 10260

TTGAGAGATA ATAAATTCAA TGAATGCGAT CTATACAATT GTGTAGTCAA TCAAAGCTAT 10320

CTCAACAACT CTAATCACGT GGTATCACTA ACTGGTAAAG AAAGAGAGCT CAGTGTAGGT 10380

AGAATGTTTG CTATGCAACC AGGTATGTTT AGGCAAATCC AAATCTTAGC AGAGAAAATG 10440

ATAGCTGAAA ATATTTTACA ATTCTTCCCT GAGAGTTTGA CAAGATATGG TGATCTAGAG 10500

CTTCAAAAGA TATTAGAATT AAAAGCAGGA ATAAGCAACA AGTCAAATCG TTATAATGAT 10560 AACTACAACA ATTATATCAG TAAATGTTCT ATCATTACAG ATCTTAGCAA ATTCAATCAG 10620 GCATTTAGAT ATGAAACATC ATGTATCTGC AGTGATGTAT TAGATGAACT GCATGGAGTA 10680 CAATCTCTGT TCTCTTGGTT GCATTTAACA ATACCTCTTG TCACAATAAT ATGTACATAT 10740 AGACATGCAC CTCCTTTCAT AAAGGATCAT GTTGTTAATC TTAATGAGGT TGATGAACAA 10800 AGTGGATTAT ACAGATATCA TATGGGTGGT ATTGAGGGCT GGTGTCAAAA ACTGTGGACC: 10860 ATTGAAGCTA TATCATTATT AGATCTAATA TCTCTCAAAG GGAAATTCTC TATCACAGCT 10920 CTGATAAATG GTGATAATCA GTCAATTGAT ATAAGCAAAC CAGTTAGACT TATAGAGGGT 10980 CAGACCCATG CACAAGCAGA TTATTTGTTA GCATTAAATA GCCTTAAATT GTTATATAAA 11040 GAGTATGCAG GTATAGGCCA TAAGCTTAAG GGAACAGAGA CCTATATATC CCGAGATATG 11100 CAGTTCATGA GCAAAACAAT CCAGCACAAT GGAGTGTACT ATCCAGCCAG TATCAAAAAA 11160 GTCCTGAGAG TAGGTCCATG GATAAACACG ATACTTGATG ATTTTAAAGT TAGTTTAGAA 11220 TCTATAGGCA GCTTAACACA GGAGTTAGAA TACAGAGGAG AAAGCTTATT ATGCAGTTTA 11280 ATATTTAGGA ACATTTGGTT ATACAATCAA ATTGCTTTGC AACTCCGAAA TCATGCATTA 11340 TGTAACAATA AGCTATATTT AGATATATTG AAAGTATTAA AACACTTAAA AACTTTTTTT 11400 AATCTTGATA GCATTGATAT GGCTTTATCA TTGTATATGA ATTTGCCTAT GCTGTTTGGT 11460 GGTGGTGATC CTAATTTOTT ATATCGAAGC TTTTATAGGA GAACTCCAGA CTTCCTTACA 11520 GAAGCTATAG TACATTCAGT GTTTGTGTTG AGCTATTATA CTGGTCACGA TTTACAAGAT 11580 AAGCTCCAGG ATCTTCCAGA TGATAGACTG AAGAAATTCT TGACATGTGT CATCACATTT 11640 GATAAAAATC CCAATGCCGA GTTTGTAACA TTGATGAGGG ATCCACAGGC TTTAGGGTCT 11700 GAAAGGCAAG CTAAAATTAC TAGTGAGATT AATAGATTAG CAGTAACAGA AGTCTTAAGT 11760 ATAGCCCCAA ACAAAATATT TTCTAAAAGT GCACAACATT ATACTACCAC TGAGATTGAT 11820 CTAAATGACA TTATGCAAAA TATAGAACCA ACTTACCCTC ATGGATTAAG AGTTGTTTAT 11880 GAAAGTTTAC CTTTTTATAA AGCAGAAAAA ATAGTTAATC TTATATCAGG AACAAAATCC 11940 ATAACTAATA TACTTGAAAA AACATCAGCA ATAGATACAA CTGATATTAA TAGGGCTACT 12000 GATATGATGA GGAAAAATAT AACTTTACTT ATAAGGATAC TTCCACTAGA TTGTAACAAA 12060 GACAAAAGAG AGTTATTAAG TTTAGAAAAT CTTAGTATAA CTGAATTAAG CAAGTATGTA 12120 AGAGAAAGAT CTTGGTCATT ATCCAATATA GTAGGAGTAA CATCGCCAAG TATTATGTTC 12180

ACAATGGACA TTAAATATAC AACTAGCACT ATAGCCAGTG GTATAATAAT AGAAAAATAT 12240

AATGTTAATA GTTTAACTCG TGGTGAAAGA GGACCCACCA AGCCATGGGT AGGCTCATCC 12300

ACGCAGGAGA AAAAAACAAT GCCAGTGTAC AACAGACAAG TTTTAACCAA AAAGCAAAGA 12360

GACCAAATAG ATTTATTAGC AAAATTAGAC TGGGTATATG CATCCATAGA CAACAAAGAT 12420

GAATTCATGG AAGAACTGAG TACTGGAACA CTTGGACTGT CATATGAAAA AGCGAAAAAG 12480

TTGTTTCCAC AATATCTAAG TGTCAATTAT TTACACCGTT TAACAGTCAG TAGTAGACCA 12540

TGTGAATTCC CTGCATCAAT ACCAGCTTAT AGAACAACAA ATTATCATTT TGATACTAGT 12600

CCTATCAATC ATGTATTAAC AGAAAAGTAT GGAGATGAAG ATATCGACAT TGTGTTTCAA 12660

AATTGCATAA GTTTTGGTCT TAGCCTGATG TCGGTTGTGG AACAATTCAC AAACATATGT 12720

CCTAATAGAA TTATTCTCAT ACCGAAGCTG AATGAGATAC ATTTGATGAA ACCTCCTATA 12780

TTTACAGGAG ATGTTGATAT CATCAAGTTG AAGCAAGTGA TAGAAAAGCA GCACATGTTC 12840

CTACCAGATA AAATAAGTTT AACCCAATAT GTAGAATTAT TCTTAAGTAA CAAAGCACTT 12900

AAATCTGGAT CTCACATCAA CTCTAATTTA ATATTAGTAC ATAAAATGTC TGATTATTTT 12960

CATAATGCTT ATATTTTAAG TACTAATTTA GCTGGACATT GGATTCTGAT TATTCAACTT 13020

ATGAAAGATT CAAAAGGTAT TTTTGAAAAA GATTGGGGAG AGGGGTACAT AACTGATCAT 13080

ATGTTCATTA ATTTGAATGT TTTCTTTAAT GCTTATAAGA CTTATTTGCT ATGTTTTCAT 13140

AAAGGTTATG GTAAAGCAAA ATTAGAATGT GATATGAACA CTTCAGATCT TCTTTGTGTT 13200

TTGGAGTTAA TAGACAGTAG CTACTGGAAA TCTATGTCTA AAGTTTTCCT AGAACAAAAA 13260

GTCATAAAAT ACATAGTCAA TCAAGACACA AGTTTGCGTA GAATAAAAGG CTGTCACAGT 13320

TTTAAGTTGT GGTTTTTAAA ACGCCTTGAT AATGCTAAAT TTACCGTATG CCCTTGGGTT 13380

GTTAACATAG ATTATCACCC AACACACATG AAAGCTATAT TATCTTACAT AGATTTAGTT 13440

AGAATGGGGT TAATAAATGT AGATAAATTA ACCATTAAAA ATAAAAACAA ATTCAATGAT 13500

GAATTTTACA CATCAAATCT CTTTTACATT AGTTATAACT TTTCAGACAA CACTCATTTG 13560

CTAACAAAAC AAATAAGAAT TGCTAATTCA GAATTAGAAG ATAATTATAA CAAACTATAT 13620

CACCCAACCC CAGAAACTTT AGAAAATATG TCATTAATTC CTGTTAAAAG TAATAATAGT 13680 AACAAACCTA AATTTTGTAT AAGTGGAAAT ACCGAATCTA TGATGATGTC AACATTCTCT 13740

AGTAAAATGC ATATTAAATC TTCCACTGTT ACCACAAGAT TCAATTATAG CAAACAAGAC 13800

TTGTACAATT TATTTCCAAT TGTTGTGATA GACAAGATTA TAGATCATTC AGGTAATACA 13860

GCAAAATCTA ACCAACTTTA CACCACCACT TCACATCAGA CATCTTTAGT AAGGAATAGT 13920

GCATCACTTT ATTGCATGCT TCCTTGGCAT CATGTCAATA GATTTAACTT TGTATTTAGT 13980

TCCACAGGAT GCAAGATCAG TATAGAGTAT ATTTTAAAAG ATCTTAAGAT TAAGGACCCC 14040

AGTTGTATAG CATTCATAGG TGAAGQAGCT GGTAACTTAT TATTACGTAC GGTAGTAGAA 14100

CTTCATCCAG ACATAAGATA CATTTACAGA AGTTTAAAAG ATTGCAATGA TCATAGTTTA 14160

CCTATTGAAT TTCTAAGGTT ATACAACGGG CATATAAACA TAGATTATGG TGAGAATTTA 14220

ACCATTCCTG CTACAGATQC AACTAATAAC ATTCATTGGT CTTATTTAGA TATAAAATTT 14280

GCAGAACCTA TTAGCATCTT TGTCTGCGAT GCTGAATTAC CTGTTACAGC CAATTGGAGT 14340

AAAATTATAA TTGAATGGAG TAAGCATGTA AGAAAGTGCA AGTACTGTTC TTCTGTAAAT 14400

AGATGCATTT TAATTGCAAA ATATCATGCT CAAGATGACA TTGATTTCAA ATTAGATAAC 14460

ATTACTATAT TAAAAACTTA CGTGTGCCTA GGTAGCAAGT TAAAAGGATC TGAAGTTTA.: 14520

TTAATCCTTA CAATAGGCCC TGCAAATATA CTTCCTGTTT TTGATGTTGT ACAAAATGCT 14580

AAATTGATAC TTTCAAGAAC TAAAAATTTC ATTATGCCTA AAAAAACTGA CAAGGAATCT 14640

ATCGATGCAG TTATTAAAAG CTTAATACCT TTCCTTTGTT ACCCTATAAC AAAAAAAGGA 14700

ATTAAGACTT CATTGTCAAA ATTGAAGAGT GTAGTTAATG GAGATATATT ATCATATTCT 14760

ATAGCTGGAC GTAATGAAGT ATTCAQCAAC AAGCTTATAA ACCACAAGCA TATGAATATC 14820

CTAAAATGGC TAGATCATGT TTTAAATTTT AGATCAGCTG AACTTAATTA CAATCATTTA 14880

TACATGATAG AGTCCACATA TCCTTACTTA AGTGAATTGT TAAATAGTTT AACAACCAAT 14940

GAGCTCAAGA AGCTGATTAA AATAACAGGT AGTGTGCTAT ACAACCTTCC CAACGAACAG 15000

TAGTTTAAAA TATCATTAAC AAGTTTGGTC AAATTTAGAT GCTAACACAT CATTATATTΛ 15060

TAGTTATTAA AAAATATACA AACTTTTCAA TAATTTAGCA TATTGATTCC AAAATTATCΛ 15120

TTTTAGTCTT AAGGGGTTAA ATAAAAGTCT AAAACTAACA ATTATACATG TGCATTCACA 15180

ACACAACGAG ACATTAGTTT TTGACACTTT TTTTCTCGT 15219 (2) INFORMATION FOR SEQ ID NO: 34:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 2166 amino acids

(B) TYPE: amino acid

(C) STRANDEDNESS:

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: protein

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 34:

Met Asp Pro He He Asn Gly Asn Ser Ala Aβn Val Tyr Leu Thr Asp 1 5 10 15

Ser Tyr Leu Lye Gly Val He Ser Phe Ser Glu Cyβ Aβn Ala Leu Gly 20 25 30

Ser Tyr Leu Phe Asn Gly Pro Tyr Leu Lys Asn Asp Tyr Thr Asn Leu 35 40 45

He Ser Arg Gin Ser Pro Leu Leu Glu His Met Asn Leu Lys Lye Leu 50 55 60

Thr He Thr Gin Ser Leu He Ser Arg Tyr His Lys Gly Glu Leu Lys 65 70 75 80

Leu Glu Glu Pro Thr Tyr Phe Gin Ser Leu Leu Met Thr Tyr Lys Ser 85 90 95

Met Ser Ser Ser Glu Gin He Ala Thr Thr Asn Leu Leu Lys Lys He 100 105 110

He Arg Arg Ala He Glu He Ser Asp Val Lys Val Tyr Ala He Leu 115 120 125

Asn Lys Leu Gly Leu Lys Glu Lys Asp Arg Val Lys Pro Asn Asn Asn 130 135 140

Ser Gly Asp Glu Asn Ser Val Leu Thr Thr He He Lys Asp Asp He 145 150 155 160

Leu Ser Ala Val Glu Aβn Asn Gin Ser Tyr Thr Asn Ser Asp Lys Ser 165 170 175

His Ser Val Asn Gin Asn He Thr He Lys Thr Thr Leu Leu Lys Lys 180 185 190 Leu Met Cys Ser Met Gin His Pro Pro Ser Trp Leu He His Trp Phe 195 200 205

Asn Leu Tyr Thr Lys Leu Asn Asn He Leu Thr Gin Tyr Arg Ser Aβn 210 215 220

Glu Val Lys Ser Hiβ Gly Phe He Leu He Aβp Aβn Gin Thr Leu Ser 225 230 235 240

Gly Phe Gin Phe He Leu Aβn Gin Tyr Gly Cyβ He Val Tyr Hiβ Lye 245 250 255

Gly Leu Lye Lys He Thr Thr Thr Thr Tyr Asn Gin Phe Leu Thr Trp 260 265 270

Lys Asp He Ser Leu Ser Arg Leu Aβn Val Cyβ Leu He Thr Trp He 275 280 285

Ser Aβn Cyβ Leu Aβn Thr Leu Aβn Lye Ser Leu Gly Leu Arg Cyβ Gly 290 295 300

Phe Aβn Aβn Val Val Leu Ser Gin Leu Phe Leu Tyr Gly Aβp Cys He 305 310 315 320

Leu Lys Leu Phe His Asn Glu Gly Phe Tyr He He Lys Glu Val Glu 325 330 335

Gly Phe He Met Ser Leu He Leu Asn He Thr Glu Glu Asp Gin Phe 340 345 350

Arg Lys Arg Phe Tyr Aβn Ser Met Leu Aβn Asn He Thr Asp Ala Ala 355 360 365

He Lys Ala Gin Lys Aep Leu Leu Ser Arg Val Cyβ Hiβ Thr Leu Leu 370 375 380

Aβp Lye Thr Val Ser Aβp Aβn He He Asn Gly Lys Trp He He Leu 385 390 395 400

Leu Ser Lys Phe Leu Lys Leu He Lys Leu Ala Gly Asp Asn Asn Leu 405 410 415

Aβn Aβn Leu Ser Glu Leu Tyr Phe Leu Phe Arg He Phe Gly Hiβ Pro 420 425 430

Met Val Aβp Glu Arg Gin Ala Met Aβp Ser Val Arg He Aβn Cyβ Aβn 435 440 445

Glu Thr Lys Phe Tyr Leu Leu Ser Ser Leu Ser Thr Leu Arg Gly Ala 450 455 460

Phe He Tyr Arg He He Lys Gly Phe Val Asn Thr Tyr Asn Arg Trp 465 470 475 480

Pro Thr Leu Arg Asn Ala He Val Leu Pro Leu Arg Trp Leu Aβn Tyr 485 490 495

Tyr Lye Leu Aβn Thr Tyr Pro Ser Leu Leu Glu He Thr Glu Aβn Aβp 500 505 510

Leu He He Leu Ser Gly Leu Arg Phe Tyr Arg Glu Phe Hiβ Leu Pro 515 520 525

Lye Lye Val Aβp Leu Glu Met He He .Aβn Asp Lys Ala He Ser Pro 530 535 540

Pro Lys Asp Leu He Trp Thr Ser Phe Pro Arg Asn Tyr Met Pro Ser 545 550 555 560

Hiβ He Gin Aβn Tyr He Glu Hiβ Glu Lye Leu Lye Phe Ser Glu Ser 565 570 575

Aβp Arg Ser Arg Arg Val Leu Glu Tyr Tyr Leu Arg Aβp Asn Lys Phe 580 585 590

Asn Glu Cys Asp Leu Tyr Asn Cys Val Val Asn Gin Ser Tyr Leu Aβn 595 600 605

Aβn Ser Aβn His Val Val Ser Leu Thr Gly Lys Glu Arg Glu Leu Ser 610 615 620

Val Gly Arg Met Phe Ala Met Gin Pro Gly Met Phe Arg Gin He Gin 625 630 635 640

He Leu Ala Glu Lys Met He Ala Glu Aen He Leu Gin Phe Phe Pro 645 650 655

Glu Ser Leu Thr Arg Tyr Gly Aβp Leu Glu Leu Gin Lys He Leu Glu 660 665 670

Leu Lye Ala Gly He Ser Aβn Lye Ser Aen Arg Tyr Aβn Aβp Asn Tyr 675 680 685

Aβn Aβn Tyr He Ser Lye Cyβ Ser He He Thr Aβp Leu Ser Lye Phe 690 695 700

Aβn Gin Ala Phe Arg Tyr Glu Thr Ser Cyβ He Cyβ Ser Asp Val Leu 705 710 715 720

Asp Glu Leu His Gly Val Gin Ser Leu Phe Ser Trp Leu His Leu Thr 725 730 735

He Pro Leu Val Thr He He Cys Thr Tyr Arg His Ala Pro Pro Phe 740 745 750 He Lys Asp His Val Val Asn Leu Asn Glu Val Asp Glu Gin Ser Gly 755 760 765

Leu Tyr Arg Tyr His Met Gly Gly He Glu Gly Trp Cys Gin Lys Leu 770 775 780

Trp Thr He Glu Ala He Ser Leu Leu Asp Leu He Ser Leu Lye Gly 785 790 795 BOO

Lye Phe Ser He Thr Ala Leu He Asn Gly Aβp Aβn Gin Ser He Asp 805 810 815

He Ser Lys Pro Val Arg Leu He Glu Gly Gin Thr His Ala Gin Ala 820 825 830

Asp Tyr Leu Leu Ala Leu Aβn Ser Leu Lye Leu Leu Tyr Lys Glu Tyr 835 840 845

Ala Gly He Gly His Lys Leu Lys Gly Thr Glu Thr Tyr He Ser Λrg 850 855 860

Asp Met Gin Phe Met Ser Lys Thr He Gin His Aβn Gly Val Tyr Tyr 865 870 875 880

Pro Ala Ser He Lye Lye Val Leu Arg Val Gly Pro Trp He Aβn ^Thr 885 890 895

He Leu Asp Asp Phe Lys Val Ser Leu Glu Ser He Gly Ser Leu Thr 900 905 910

Gin Glu Leu Glu Tyr Arg Gly Glu Ser Leu Leu Cys Ser Leu He Phe 915 920 925

Arg Asn He Trp Leu Tyr Asn Gin He Ala Leu Gin Leu Arg Asn His 930 935 940

Ala Leu Cyβ Aβn Aβn Lye Leu Tyr Leu Aβp He Leu Lye Val Leu Lye 945 950 955 S'60

Hiβ Leu Lye Thr Phe Phe Aen Leu Aβp Ser He Aβp Met Ala Leu Ser 965 970 975

Leu Tyr Met Aβn Leu Pro Met Leu Phe Gly Gly Gly Aβp Pro Asn Leu 980 985 990

Leu Tyr Arg Ser Phe Tyr Arg Arg Thr Pro Asp Phe Leu Thr Glu Ala 995 1000 1005

He Val His Ser Val Phe Val Leu Ser Tyr Tyr Thr Gly His Asp Leu 1010 1015 1020 Gin Asp Lys Leu Gin Asp Leu Pro Asp Asp Arg Leu Aβn Lye Phe Leu 1025 1030 1035 1040

Thr Cyβ Val He Thr Phe Aβp Lys Asn Pro Asn Ala Glu Phe Val Thr 1045 1050 1055

Leu Met Arg Aβp Pro Gin Ala Leu Gly Ser Glu Arg Gin Ala Lye He 1060 1065 1070

Thr Ser Glu He Aβn Arg Leu Ala Val Thr Glu Val Leu Ser He Ala 1075 1080 1085

Pro Asn Lys He Phe Ser Lys Ser Ala Gin His Tyr Thr Thr Thr Glu 1090 1095 1100

He Asp Leu Asn Asp He Met Gin Asn He Glu Pro Thr Tyr Pro His 1105 1110 1115 1120

Gly Leu Arg Val Val Tyr Glu Ser Leu Pro Phe Tyr Lys Ala Glu Lys 1125 1130 1135

He Val Asn Leu He Ser Gly Thr Lys Ser He Thr Asn He Leu Glu 1140 1145 1150

Lye Thr Ser Ala He Aβp Thr Thr Asp He Asn Arg Ala Thr Asp Met 1155 1160 1165

Met Arg Lys Aβn He Thr Leu Leu He Arg He Leu Pro Leu Aβp Cyβ 1170 1175 1180

Aβn Lye Aβp Lys Arg Glu Leu Leu Ser Leu Glu Asn Leu Ser He Thr 1185 1190 1195 1200

Glu Leu Ser Lys Tyr Val Arg Glu Arg Ser Trp Ser Leu Ser Asn He 1205 1210 1215

Val Gly Val Thr Ser Pro Ser He Met Phe Thr Met Asp He Lys Tyr 1220 1225 1230

Thr Thr Ser Thr He Ala Ser Gly He He He Glu Lys Tyr Asn Val 1235 1240 1245

Asn Ser Leu Thr Arg Gly Glu Arg Gly Pro Thr Lys Pro Trp Val Gly 1250 1255 1260

Ser Ser Thr Gin Glu Lys Lys Thr Met Pro Val Tyr Asn Arg Gin Val 1265 1270 1275 1280

Leu Thr Lys Lys Gin Arg Asp Gin He Asp Leu Leu Ala Lye Leu Asp 1285 1290 1295

Trp Val Tyr Ala Ser He Asp Asn Lys Asp Glu Phe Met Glu Glu Leu 1300 1305 1310

Ser Thr Gly Thr Leu Gly Leu Ser Tyr Glu Lys Ala Lys Lys Leu Phe 1315 1320 1325

Pro Gin Tyr Leu Ser Val Asn Tyr Leu Hiβ Arg Leu Thr Val Ser Ser 1330 1335 1340

Arg Pro Cys Glu Phe Pro Ala Ser He Pro Ala Tyr Arg Thr Thr Asn 1345 1350 1355 1360

Tyr His Phe Asp Thr Ser Pro He Asn. His Val Leu Thr Glu Lys Tyr 1365 1370 1375

Gly Asp Glu Asp He Asp He Val Phe Gin Asn Cys He Ser Phe Gly 1380 1385 1390

Leu Ser Leu Met Ser Val Val Glu Gin Phe Thr Aβn He Cyβ Pro Asn 1395 1400 1405

Arg He He Leu He Pro Lye Leu Aβn Glu He Hiβ Leu Met Lye Pro 1410 1415 1420

Pro He Phe Thr Gly Aβp Val Aβp He He Lye Leu Lye Gin Val He 1425 1430 1435 1440

Gin Lye Gin Hiβ Met Phe Leu Pro Aβp Lye He Ser Leu Thr Gin Tyr 1445 1450 1455

Val Glu Leu Phe Leu Ser Asn Lys Ala Leu Lye Ser Gly Ser His He 1460 1465 1470

Asn Ser Asn Leu He Leu Val His Lys Met Ser Asp Tyr Phe Hiβ λβn 1475 1480 1485

Ala Tyr He Leu Ser Thr Aβn Leu Ala Gly Hiβ Trp He Leu He He 1490 1495 1500

Gin Leu Met Lye Asp Ser Lye Gly He Phe Glu Lye Asp Trp Gly Glu 1505 1510 1515 1520

Gly Tyr He Thr Asp His Met Phe He Asn Leu Asn Val Phe Phe Asn 1525 1530 1535

Ala Tyr Lys Thr Tyr Leu Leu Cys Phe Hiβ Lye Gly Tyr Gly Lye Ala 1540 1545 1550

Lye Leu Glu Cyβ Aβp Met Aβn Thr Ser Aβp Leu Leu Cys Val Leu Glu 1555 1560 1565

Leu He Asp Ser Ser Tyr Trp Lys Ser Met Ser Lys Val Phe Leu Glu 1570 1575 1580 Gin Lys Val He Lys Tyr He Val Asn Gin Asp Thr Ser Leu Arg Arg 1585 1590 1595 1600

He Lys Gly Cyβ Hiβ Ser Phe Lys Leu Trp Phe Leu Lys Arg Leu Asp 1605 1610 1615

Asn Ala Lys Phe Thr Val Cys Pro Trp Val Val Asn He Asp Tyr His 1620 1625 1630

Pro Thr Hiβ Met Lye Ala He Leu Ser Tyr He Asp Leu Val Arg Met 1635 1640 1645

Gly Leu He Asn Val Asp Lys Leu Thr He Lys Asn Lys Asn Lys Phe 1650 1655 1660

Asn Asp Glu Phe Tyr Thr Ser Aβn Leu Phe Tyr He Ser Tyr Aβn Phe 1665 1670 1675 ^-1680

Ser Asp Asn Thr Hiβ Leu Leu Thr Lys Gin He Arg He Ala Asn Ser 1685 1690 1695

Glu Leu Glu Asp Asn Tyr Asn Lys Leu Tyr His Pro Thr Pro Glu Thr 1700 1705 1710

Leu Glu Asn Met Ser Leu He Pro Val Lys Ser Aβn Aβn Ser Aβn Lye 1715 1720 1725

Pro Lye Phe Cyβ He Ser Gly Aβn Thr Glu Ser Met Met Met Ser Thr 1730 1735 1740

Phe Ser Ser Lys Met His He Lys Ser Ser Thr Val Thr Thr Arg Phe 1745 1750 1755 1760

Asn Tyr Ser Lys Gin Aβp Leu Tyr Aβn Leu Phe Pro He Val Val He 1765 1770 1775

Asp Lys He He Asp His Ser Gly Asn Thr Ala Lys Ser Asn Gin Leu 1780 1785 1790

Tyr Thr Thr Thr Ser His Gin Thr Ser Leu Val Arg Asn Ser Ala Ser 1795 1800 1805

Leu Tyr Cys Met Leu Pro Trp His His Val Asn Arg Phe Asn Phe Val 1810 1815 1820

Phe Ser Ser Thr Gly Cys Lys He Ser He Glu Tyr He Leu Lys Aep 1825 1830 1835 1840

Leu Lys He Lys Asp Pro Ser Cys He Ala Phe He Gly Glu Gly Ala 1845 1850 1855 Gly Asn Leu Leu Leu Arg Thr Val Val Glu Leu His Pro Aβp He Arg 1860 1865 1870

Tyr He Tyr Arg Ser Leu Lye Aβp Cys Asn Asp His Ser Leu Pro He 1875 1880 1885

Glu Phe Leu Arg Leu Tyr Asn Gly His He Asn He Asp Tyr Gly Glu 1890 1895 1900

Aen Leu Thr He Pro Ala Thr Asp Ala Thr Asn Aβn He Hiβ Trp Ser 1905 1910 1915 1920

Tyr Leu His He Lys Phe Ala Glu Pro He Ser He Phe Val Cyβ Asp 1925 1930 1935

Ala Glu Leu Pro Val Thr Ala Asn Trp Ser Lys He He He Glu Trp 1940 1945 1950

Ser Lye Hiβ Val Arg Lye Cys Lys Tyr Cys Ser Ser Val Asn Arg C!ys 1955 1960 1965

He Leu He Ala Lys Tyr His Ala Gin Asp Asp He Asp Phe Lys Leu 1970 1975 1980

Asp Asn He Thr He Leu Lys Thr Tyr Val Cys Leu Gly Ser Lys leu 1985 1990 1995 2000

Lys Gly Ser Glu Val Tyr Leu He Leu Thr He Gly Pro Ala Asn He 2005 2010 2015

Leu Pro Val Phe Asp Val Val Gin Asn Ala Lys Leu He Leu Ser Arg 2020 2025 2030

Thr Lys Asn Phe He Met Pro Lys Lys Thr Asp Lys Glu Ser He Asp 2035 2040 2045

Ala Val He Lys Ser Leu He Pro Phe Leu Cys Tyr Pro He Thr Lys 2050 2055 2060

Lys Gly He Lys Thr Ser Leu Ser Lys Leu Lys Ser Val Val Asn Gly 2065 2070 2075 2080

Asp He Leu Ser Tyr Ser He Ala Gly Arg Asn Glu Val Phe Ser Asn 2085 2090 2095

Lye Leu He Aβn Hiβ Lye Hiβ Met Asn He Leu Lys Trp Leu Asp HLs 2100 2105 2110

Val Leu Aβn Phe Arg Ser Ala Glu Leu Aβn Tyr Asn His Leu Tyr Met 2115 2120 2125

He Glu Ser Thr Tyr Pro Tyr Leu Ser Glu Leu Leu Asn Ser Leu Thr 2130 2135 2140

Thr Aβn Glu Leu Lys Lys Leu He Lys He Thr Gly Ser Val Leu Tyr 2145 2150 2155 2160

Asn Leu Pro Asn Glu Gin 2165

(2) INFORMATION FOR SEQ ID NO: 35:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 35: CATATCACTC ACTCTGGGAT GQAG 24

(2) INFORMATION FOR SEQ ID NO: 36:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 36: TCAGAACATC AAGCACCGCC 20

(2) INFORMATION FOR SEQ ID NO: 37:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 37: ACAGTCAAGA CTGAGATGAG 20

(2) INFORMATION FOR SEQ ID NO: 38:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:38: AAGAGTCAGA TACATGTGGA 20

(2) INFORMATION FOR SEQ ID NO: 39:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 39: ACATGAATCA GCCTAAAGTC 20

(2) INFORMATION FOR SEQ ID NO: 40:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO: 40: CCGAAAGAGT TCCTGCGTTA CGACC 25

(2) INFORMATION FOR SEQ ID NO:41:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 41: CAGTCCACAC AAGTACCAGG 20

(2) INFORMATION FOR SEQ ID NO: 42:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 42: GTCAGAAGCT GTGGACCATC 20

(2) INFORMATION FOR SEQ ID NO: 43:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:43: AATATTGCTA CAACAATGGC 20

(2) INFORMATION FOR SEQ ID NO: 44:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 44: ACTCTTCATT CCTAGACTGG 20

(2) INFORMATION FOR SEQ ID NO: 45:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:45: GTCCAATTAT GACTATGAAC 20

(2) INFORMATION FOR SEQ ID NO: 46:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic) (xi) SEQUENCE DESCRIPTION: SEQ ID NO:46: AGAACAGACA TGAAGCTTGC 20

(2) INFORMATION FOR SEQ ID Nθ:47:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 47: CCAACAAGGA ATGCTTCTAG 20

(2) INFORMATION FOR SEQ ID NO: 48:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 48: ACAGCACTAT CTATGATTGA CCTGG 25

(2) INFORMATION FOR SEQ ID NO: 49:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 49: GCAACATGGT TTACACATGC 20

(2) INFORMATION FOR SEQ ID NO: 50:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 50: AGATTGAGAG TTGATCGAGG 20

(2) INFORMATION FOR SEQ ID NO: 51:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 51: AGGAGATACT TAAACTAAGC 20

(2) INFORMATION FOR SEQ ID NO: 52:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 52: TAAGCTTATG CCTTTCAGCG 20

(2) INFORMATION FOR SEQ ID NO: 53:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO:53: TTAACGGACC TAAGCTGTGC 20

(2) INFORMATION FOR SEQ ID NO: 54:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 54: GAAACAGATT ATTATGACGG 20

(2) INFORMATION FOR SEQ ID NO: 55:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 24 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 55: CGGGCTATCT AGGTGAACTT CAGG 24 (2) INFORMATION FOR SEQ ID NO: 56:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 56: ATTTGGATAT GGAATATQAG 20

(2) INFORMATION FOR SEQ ID NO: 57:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 57: ACTCAACTGA ACTACCAGTG 20

(2) INFORMATION FOR SEQ ID NO: 58:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 58: AAGAACATCA TGTATTTCAG 20 (2) INFORMATION FOR SEQ ID NO: 59:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 59: TTATCAACGC ACTGCTCATG 20

(2) INFORMATION FOR SEQ ID NO: 60:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 60: ATTTTCAGCA ATCACTTGGC ATGCC 25

(2) INFORMATION FOR SEQ ID NO: 61:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 61: GCCTCTGTGC AAACAAGCTG 20

(2) INFORMATION FOR SEQ ID NO: 62: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 62: TCTCTAGTTA CTCTAGCAGC 20

(2) INFORMATION FOR SEQ ID NO: 63:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 63: AGGTCGTTGT TTGTGAGGAG 20

(2) INFORMATION FOR SEQ ID NO: 64:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 64: TCGTCCTCTT CTTTACTGTC 20

(2) INFORMATION FOR SEQ ID NO: 65: (i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 65: CCGTCCTCGA GCTAGCCTCG 20

(2) INFORMATION FOR SEQ ID NO: 66:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 66: CTCCTCCAGG CTCACATTGG 20

(2) INFORMATION FOR SEQ ID NO: 67:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 67: GGGTTGGTAC ATAGCTCTGC 20

(2) INFORMATION FOR SEQ ID NO: 68: (i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 25 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 68: CACCCATCTG ATATTTCCCT GATGG 25

(2) INFORMATION FOR SEQ ID NO: 69:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 69: TGGTTGACAG TACAAATCTG 20

(2) INFORMATION FOR SEQ ID NO: 70:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 70:

CTGAAATGGG AAGATTGTGC 20

(2) INFORMATION FOR SEQ ID NO: 71:

(i) SEQUENCE CHARACTERISTICS: (A) LENGTH: 20 base pairs (B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 71: AGCAATCTAC ACTGCCTACC 20

(2) INFORMATION FOR SEQ ID NO:72:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 72: TCACAGATGA TTCAATTATC 20

(2) INFORMATION FOR SEQ ID NO: 73:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 baβe pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 73: GATCCTAGAT ATAAGTTCTC 20

(2) INFORMATION FOR SEQ ID NO: 74:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 baβe pairβ

(B) TYPE: nucleic acid (C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 74: ACCAAACAAA GTTGGGTAAG G 21

(2) INFORMATION FOR SEQ ID NO: 75:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 75: GGGGGATCCA TCCCTAATCC TGCTCTTGTC CC 32

(2) INFORMATION FOR SEQ ID NO: 76:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 20 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 76: GATTCCTCTG ATGGCTCCAC 20

(2) INFORMATION FOR SEQ ID NO: 77:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 21 baβe pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single (D) TOPOLOGY: linear (ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 77: TAACAGTCAA GGAGACCAAA G 21

(2) INFORMATION FOR SEQ ID NO: 78:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 32 base pairs

(B) TYPE: nucleic acid

(C) STRANDEDNESS: single

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 78: GGGAAGCTTA ACCCTAATCC TGCCCTAGGT GG 32

(2) INFORMATION FOR SEQ ID NO: 9:

(i) SEQUENCE CHARACTERISTICS:

(A) LENGTH: 22 base pairβ

(B) TYPE: nucleic acid

(C) STRANDEDNESS: βingle

(D) TOPOLOGY: linear

(ii) MOLECULE TYPE: RNA (genomic)

(xi) SEQUENCE DESCRIPTION: SEQ ID NO: 79: ACCAGACAAA GCTGGGAATA GA 22

Claims (46)

What is claimed is:

1. An isolated, recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales having at least one attenuating mutation in the 3 ' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene.

2. The virus of Claim 1 wherein the virus is from the Family Paramyxoviridae.

3. The virus of Claim 2 wherein the virus is from the Subfamily Paramyxovirinae.

4. The virus of Claim 3 wherein the virus is from the Genus Morbillivirus .

5. The virus of Claim 4 wherein the virus is measles virus.

6. The measles virus of Claim 5 wherein:

(a) the at least one attenuating mutation in the 3 ' genomic promoter region is selected from the group consisting of nucleotide 26 (A —» T) , nucleotide 42 (A -> T or A -» C) and nucleotide 96 (G →

A) , where these nucleotides are presented in positive strand, antigenomic, message sense; and

(b) the at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 331 (isoleucine

— threonine) , 1409 (alanine — > threonine), 1624 (threonine —> alanine) , 1649 (arginine -»methionine) , 1717 (aspartic acid -» alanine) , 1936 (histidine —> tyrosine) , 2074 (glutamine - arginine) and 2114 (arginine — lysine) .

7. The virus of Claim 3 wherein the virus e Genus Paramyxovirus .

8. The virus of Claim 7 wherein the virus arainfluenzae virus type 3 (PIV-3) .

9. The PIV-3 of Claim 8 wherein:

(a) the at least one attenuating mutation in the 3 ^» genomic promoter region iβ selected from the group consisting of nucleotide 23 (T → C) , nucleotide 24 (C -» T) , nucleotide 28 (G → T) and nucleotide 45 (T —> A) , where these nucleotides are presented in positive strand, antigenomic, message sense; and

(b) the at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 942 (tyrosine —> histidine) , 992 (leucine → phenylalanine) , 1292 (leucine —> phenylalanine) , and 1558 (threonine — > isoleucine) .

10. The virus of Claim 3 wherein the virus e Genus KuJbulavirus .

11. The virus of Claim 2 wherein the virus e Subfamily Pneumovirinae.

12. The virus of Claim 11 wherein the virus e Genus Pneumovirus .

13. The virus of Claim 12 wherein the virus is human respiratory syncytial virus (RSV) subgroup B.

14. The virus of Claim 13 wherein:

(a) the at least one attenuating mutation in the 3 ' genomic promoter region is selected from the group consisting of nucleotide 4 (C —»^■ G) and the insertion of an additional A in the stretch of A's at nucleotides 6-11, where these nucleotides are presented in positive strand, antigenomic, message sense; and

(b) the at least one attenuating mutation in the RNA polymerase gene is selected from the group consisting of nucleotide changes which produce changes in an amino acid selected from the group consisting of residues 353 (arginine —» lysine) , 451 (lysine → arginine) , 1229 (aspartic acid — asparagine), 2029 (threonine — isoleucine) and 2050 (asparagine — > aspartic acid) .

15. The virus of Claim 1 wherein the virus is from the Family Rhabdoviridae.

16. The virus of Claim 1 wherein the virus is from the Family Filoviridae.

17. A vaccine comprising an isolated, recombinantly-generated, attenuated, nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales according to Claim 1 and a physiologically acceptable carrier.

18. The vaccine of Claim 17 comprising a measles virus according to Claim 5 and a physiologically acceptable carrier.

19. The vaccine of Claim 18 comprising a measles virus according to Claim 6 and a physiologically acceptable carrier.

20. The vaccine of Claim 17 comprising a PIV-3 according to Claim 8 and a physiologically acceptable carrier.

21. The vaccine of Claim 20 comprising a PIV-3 according to Claim 9 and a physiologically acceptable carrier.

22. The vaccine of Claim 17 comprising an RSV subgroup B according to Claim 13 and a physiologically acceptable carrier.

23. The vaccine of Claim 22 comprising an RSV subgroup B according to Claim 14 and a physiologically acceptable carrier.

24. A method for immunizing an individual to induce protection against a nonsegmented, negative- sense, single stranded RNA virus of the Order Mononegavirales which comprises administering to the individual the vaccine of Claim 17.

25. The method of Claim 24 wherein the vaccine is the vaccine of Claim 18.

26. The method of Claim 25 wherein the vaccine is the vaccine of Claim 19.

27. The method of Claim 24 wherein the vaccine is the vaccine of Claim 20.

28. The method of Claim 27 wherein the vaccine is the vaccine of Claim 21.

29. The method of Claim 24 wherein the vaccine is the vaccine of Claim 22.

30. The method of Claim 29 wherein the vaccine is the vaccine of Claim 23.

31. An isolated nucleic acid molecule comprising a measles virus sequence in positive strand, antigenomic message sense selected from the group consisting of 1977 wild-type strain (SEQ ID NO:3), 1983 wild-type strain (SEQ ID NO: 5) where the nucleotide 2499 is G or C, Montefiore wild- type strain (SEQ ID NO:7) , Rubeovax™ vaccine strain (SEQ ID N0:9), where the nucleotide 2143 is T or C, Moraten vaccine strain (SEQ ID NO:ll), Schwarz vaccine strain (SEQ ID N0:11), where the nucleotide 4917 is C and the nucleotide 4924 is C, and Zagreb vaccine strain (SEQ ID NO:13), and the complementary genomic sequences thereof.

32. An isolated nucleic acid molecule comprising a PIV-3 sequence in positive strand, antigenomic message sense selected from the group consisting of cp45 vaccine strain grown in fetal rhesus lung cells (SEQ ID NO: 19) and cp45 vaccine strain grown in Vero cells (SEQ ID N0:21), and the complementary genomic sequences thereof.

33. A composition which comprises a transcription vector comprising an isolated nucleic acid molecule encoding a genome or antigenome of a nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales having at least one attenuating mutation in the 3 ' genomic promoter region and having at least one attenuating mutation in the RNA polymerase gene, together with at least one expression vector which comprises at least one isolated nucleic acid molecule encoding the trans-acting proteins necessary for encapsidation, transcription and replication, whereby upon expression an infectious attenuated virus is produced.

34. The composition of Claim 33 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes a measles virus according to Claim 5 and the at least one expression vector comprises at least one isolated nucleic acid molecule encoding the trans-acting proteins N, P and .

35. The composition of Claim 34 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes a measles virus according to Claim 6.

36. The composition of Claim 33 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes a PIV-3 according to Claim 8 and the at least one expression vector comprises at least one isolated nucleic acid molecule encoding the transacting proteins NP, P and L.

37. The composition of Claim 36 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes a PIV-3 according to Claim 9.

38. The composition of Claim 33 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes an RSV subgroup B according to Claim 13 and the at least one expression vector comprises at least one isolated nucleic acid molecule encoding the trans-acting proteins N, P, and M2.

39. The composition of Claim 38 wherein the transcription vector comprises an isolated nucleic acid molecule which encodes an RSV subgroup B according to Claim 14.

40. A method for producing infectious attenuated nonsegmented, negative-sense, single stranded RNA virus of the Order Mononegavirales which comprises transforming or transfecting host cells with the at least two vectors of Claim 33 and culturing the host cells under conditions which permit the co- expression of these vectors so as to produce the infectious attenuated virus.

41. The method of Claim 40 wherein the virus is the measles virus of Claim 5.

42. The method of Claim 41 wherein the virus is the measles virus of Claim 6.

43. The method of Claim 40 wherein the virus is the PIV-3 of Claim 8.

44. The method of Claim 43 wherein the virus is the PIV-3 of Claim 9.

45. The method of Claim 40 wherein the virus is the RSV subgroup B of Claim 13.

46. The method of Claim 45 wherein the virus is the RSV subgroup B of Claim 14.