MXPA00009256A - Mutations responsible for attenuation in measles virus or human respiratory syncytial virus subgroup b - Google Patents

Abstract

Isolated, recombinantly-generated, attenuated measles viruses and respiratory syncytial subgroup B viruses having defined attenuating mutations are described. Vaccines are formulated comprising such viruses and a physiologically acceptable carrier. The vaccines are used for immunizing an individual to induce protection against measles virus or respiratory syncytial subgroup B virus.

Description

MUTATIONS RESPONSIBLE FOR ATTENUATION IN THE VIRUSES OF MEASLES OR IN SUB-GROUP B OF VIRUS SINCTIAL RESPIRATORY HUMAN FIELD OF THE INVENTION This invention relates to attenuated, isolated, recombinant-generated, measles virus, or subgroup B of human respiratory syncytial virus having specified attenuating mutations. This invention was made with the support of the government under a concession granted by the Public Health Service. The government has certain rights in the invention.

BACKGROUND OF THE INVENTION Viruses with single-stranded RNA, negative sense, enveloped, are organized and expressed in a unique way. The genomic RNA of single-stranded viruses, in the negative sense, serve as two template functions in the context of a nucleocapsid: as a template for the synthesis of messenger RNAs (mRNA) and as REF. : 123231 a template for the synthesis of the strand (+) of the antigenome. Viruses with single-stranded RNA, in a negative sense, encode and package their own RNA-dependent RNA polymerase. Messenger RNAs are synthesized only once the nucleocapsid has entered the cytoplasm of the infected cell. Viral replication occurs after RNA synthesis and requires the continuous synthesis of viral proteins. The (+) strand of the newly synthesized antigenome serves as the template to generate additional copies of the strand genomic RNA (-). The polymerase complex acts and achieves transcription and replication by coupling the cis-acting signals at the 3 'end of the genome, in particular, the promoter region. The viral genes are then transcribed from the genome template, unidi reccionalment e, from its 3 'end to the 5' end. There is always less mRNA produced from the genes located in the 3 'direction (for example, the polymerase (L) gene) in relation to its neighbors located in the 5' direction (ie the nucleoprotein gene s (N )). For the therefore, there is always a mRNA abundance gradient according to the position of the genes relative to the 3 'end of the genome. Based on the reclassification revised in 1993 by the International Committee on Taxonomy of Viruses, a Designated Order Mononegavirales has been established. This Order contains three families of enveloped viruses, with single-stranded, unsegmented RNA genomes of polarity minus (negative sense). These families are the Paramyxoviridae, Rhabdovir idae and Filoviridae. The family Par amyxoviridae has been further divided into two subfamilies, the Paramyxo i rinae and the Pneumo i rina e. The subfamily Paramyxovi rinae contains three genera, the Paramyxovirus,. Rubulavirus and Morbillibiruses The Pneurovi r inae family contains the genus Pneumovius rus. The new classification is based on morphological criteria, the organization of the viral genome, the biological activities and the lack of connection in the sequences, of the genes and of the genetic products. The distinctive morphological characteristic between the enveloped viruses, for the subfamily Paramyxovirinae is the size and shape of the nucleocapsids (diameter of 18 mm, length of 1 mm, separation of 5.5 nm), which have a helical symmetry to the left. The biological criteria are: 1) antigenic cross-reactivity between the members of a genus, and 2) the presence of neuraminidase activity in the genera Pa ramyx or vi rus, R ubula vi ru and their absence in the genus Morbi 11 i saw rus. In addition, variations in the coding potential of the P gene are considered, as is the presence of an additional gene (SH) in Rubul a i rus. Pneumoviruses can be distinguished from Paraxymo i r inae, morphologically, because they contain narrow nucleocapsids. In addition, pneumoviruses have major differences in the number of cistrons encoding the protein (10 in pneumoviruses versus 6 in Paramyxovirinae) and a binding protein (G) that is very different from that of Paramyxovirinae. Although Paramyxoviruses and pneumoviruses have six proteins that seem to correspond in their function (N, P, M, G / H / HN, F and L), only the last two proteins exhibit a significant sequence connection between the two subfamilies. Many pneumo-ral proteins lack the counterparts in most of the Paramyxo irus, especially the non-structural proteins NS1 and NS2, the small hydrophobic protein SH, and a second M2 protein. Some amino acid proteins, especially C and V, lack the counterparts in the pneumoviruses. However, the basic genomic organization of pneumoviruses and paramyxoviruses is the same. The same is true for rhabdoviruses and filoviruses. Table 1 presents the common taxonomic classification of these viruses, together with examples of each genus.

Table 1 Classification of viruses with single-stranded RNA, negative direction, non-segmented, of the Order Mononegavirale s Family Paramyxovi ridae Subfamily Paramyxovirinae Genus Pa ramyxovius Sendai virus (mouse parainfluenza type 1 virus) Ainf luenz to human pair virus (PIV) types 1 and 3 Bovine influenzin virus (BPV) type 3 Genus Rubulavirus Simian virus 5 (SV) (parainf luenz to canine type 2 virus) Papuan virus 10 Virus of the Newcas t le disease (NDV) (Paramyxovirus 1 aví cola) Parainf luenz to human viruses, types 2, 4a and 4b 15 Genus Morbi 11 iv virus Measles virus (MV) Morbil dolphin livin virus Canine distemper virus (CDV) Virus of the pest of 20 small ruminants Virus of distemper foci Virus of rinderpest Subfamily Pneumovi r inae Genus Pneumovirus 25 Respiratory syncytial virus Human (RSV) Bovine Respiratory Syncytial Virus Pneumonia Virus of Mice Virus of the Intestine of the Turkey Family Rhabdovi r idae Genus Lys a vi ru s Rabies virus Genus Ves í cul ovi rus Vesicular stomatitis virus Genus Ephemerovirus Bovine ephemeral fever virus Family Filoviridae Genus Fi lo vi ru s Virus Marbug Vaccines of any kind are not available for many of these viruses. In this way, there is a need to develop vaccines against those pathogens of humans and animals. These vaccines should produce a protective immune response in the recipient. Qualitative and quantitative characteristics Of this favorable response, they are extrapolated from those observed in the overvirus of infection by natural virus, who, in general, are protected from reinfection by the same viruses or by highly related viruses, for a significant time afterwards. A variety of approaches can be considered in the search for the development of such vaccines, including the use of: (1) individual, purified viral protein vaccines (subunit vaccines); (2) preparations of whole viruses inactivated; and (3) live, attenuated viruses. . Subunit vaccines have the desirable characteristic that they are pure, can be defined and can be produced relatively easily, in abundance, through various means, including recombinant DNA expression methods. To date, with the notorious exception of the hepatitis B surface antigen, viral subunit vaccines have, in general, produced only short-term and / or inadequate immunity, particularly in recipients without affectation.

Preparations of the whole poliovirus (IPV), inactivated with formalin, and hepatitis A, have proven to be safe and effective. In contrast, immunization with similarly inactivated whole viruses, such as respiratory syncytial virus and measles virus vaccines, produced unfavorable immune responses and / or response profiles that predisposed the vaccinated to an exaggerated or aberrant disease when confronted Subsequently with the natural or "wild type" virus. The first attempts (1966) to vaccinate young children, used inactivated RSV vaccine with formalin, administered parenterally. Unfortunately, several field tests of this vaccine revealed serious adverse reactions-the development of a severe disease with unusual characteristics followed by natural, subsequent infection with RSV (Bibliographies 1.2). It has been suggested that this RSV antigen, treated with formalin, produced an immune response profile, abnormal or unbalanced, predisposing the vaccinated to RSV disease (3,4).

Subsequently, candidates for live, attenuated RSV vaccine were generated by cold passage or chemical mutagenesis. It was found that these strains of RSV had a reduced virulence in seropositive adults. Unfortunately, they proved to be either under or under cauterized when provided to seronegative infants; in some cases it was also found that they lacked genetic stability (5,6). Another vaccination approach using parenteral administration of the live virus was ineffective and efforts in that direction were discontinued (7). Notably, these live RSV vaccines were never associated with the improvement of the disease, as was observed with the formalin inactivated RSV vaccine, described above. There are usually no approved RSV vaccines for administration to humans, although clinical trials are now in progress with strains of RSV obtained by cold passage, subjected to chemical mutagenesis, designated A2 and B-1. Live derivatives, appropriately attenuated, of wild type viruses, offer a distinct advantage as candidates for vaccines. As live replication agents, they initiate infection in the containers, during which the viral gene products are expressed, processed and presented in the context of MHC class I and II molecules, specific to those vaccinated, producing immune responses humoral and mediated by the cells, as well as the coordinated cytosine and chemokine patterns, which were parallel to the immune-protective profile of the overlying bacteria of the natural infection. This favorable immune response pattern is contrasted with the bounded responses, produced by inactive or subunit vaccines, which are typically Aestrinidated largely to the humoral immune recognition arm. In addition, the immune response profile produced by some vaccines of whole viruses, inactivated with formalin, for example measles virus and respiratory syncytial virus vaccines, developed in the 1960s, have not failed only to provide sustained protection, but also fact have led to the predisposition to an aberrant, exaggerated and even fatal disease, when the recipient of the vaccine is subsequently confronted with the wild type virus. Although live attenuated viruses have highly desirable characteristics as candidates for vaccines, they have proven difficult to develop. The puzzle of the difficulty lies in the need to isolate a derivative of wild type virus, which has lost its potential to cause the disease (ie, virulence), and which at the same time retains sufficient replication competence to infect the recipient and produce the desired immune response profile, in an adequate abundance. Historically, this delicate balance between virulence and attenuation has been achieved through the passage, in series, of a viral, wild type isolated product, through different tissues or host cells, under varying growth conditions (such as as the temperature). This process presumably favors the growth of viral variants (mutants), some of the which have the characteristics of attenuation, favorable. Occasionally the additional attenuation is achieved through chemical mutagenesis as such. This propagation scheme, typically leads to the appearance of virus derivatives, which are sensitive to temperature, which have adapted to the cold and / or which have altered their host variety - one or all of which are changes that arise from viruses that cause diseases, of the type if 1 ves t re - that is, changes that may be associated with attenuation. Several types of live virus vaccines, including those for the prevention of measles and mumps (which are paramyxoviruses) and for protection against polio and rubella (which are viruses with positive strand RNA) have been generated Through this approach and provide the main support of common immunization regimes in childhood, throughout the world. However, this means to generate candidates for live, attenuated virus vaccines is delayed and, in the best of cases unpredictable, based largely on the selective result of randomly occurring genomic mutants with desirable attenuation characteristics. The resulting viruses can have the desired phenotype in vi t ro, and even appear to be attenuated in animal models, however, all very often remain or subatenuated or over-dosed in the human or animal host for which they intend to be used as candidates of vaccine. Even with regard to current vaccines in use, there is still a need for more effective vaccines. For example, common measles vaccines provide reasonably good protection. However, recent measles epidemics suggest deficiencies in the efficacy of current vaccines. Despite maternal immunization, high proportions of acute measles infection have been reported in children younger than 1 year, reflecting the inability of vaccines to induce measles antibody levels, compared with those developed after infection with wild-type measles (8,9,10). As a result, mothers immunized with vaccines are less able to provide their infants with enough passive antibodies derived through the placenta to protect newborns beyond the first few months of their lives. Acute measles infections in adolescents and young adults, previously immunized, point to an additional problem, these secondary failures of vaccines indicate limitations in the ability of common vaccines to induce and maintain antiviral protection, ie abundant and long-lasting (11,12,13). Recently another potential problem was also revealed. The hemagglutinin protein of the wild type 'measles', isolated during the last 15 years, has presented a progressively increasing distance of the vaccine strains (14). This "gradual antigenic shift" has led to legitimate concerns that vaccine strains may not contain the ideal antigenic repertoire necessary to provide optimal protection. This way, there is a need for better vaccines. A better understanding of these viruses would help in the rational design of vaccines, in particular by identifying virally encoded virulence determinants, as well as those genomic changes that are responsible for the attenuation. Previously, in the provisional US application 60 / 026,823 and in the International Application PC / US 97/16718, both of which are incorporated herein by reference, the generation and isolation of viruses with single-stranded, sense RNA was described. negative, non-segmented, attenuated, recombinantly generated, of the order Mononega vi ral is that they have at least one attenuating mutation in the region of the 3 'genomic promoter and that they have at least one attenuating mutation in the RNA polymerase gene. The identification of mitigating changes in other regions of the genomes of these viruses would further assist the rational design of vaccines.

BRIEF DESCRIPTION OF THE INVENTION Accordingly, an objective of this invention is to identify additional regions of the genomes of the measles virus and subgroup B of the human respiratory syncytial virus, wherein the mutations result in the attenuation of those viruses. A further object of this invention is to produce recombinantly generated viruses, which incorporate those attenuating mutations in their genomes. Still a further object of this invention is to formulate vaccines containing those attenuated viruses. These and other objects of the invention, as discussed above, are achieved through the generation and isolation of measles virus or subgroup B of attenuated, recombinantly generated human respiratory syncytial virus that has specified attenuating mutations. In the case of the measles virus, one or more attenuating mutations are selected from the group consisting of: (1) for the N gene, changes in nucleotides that produce changes in an amino acid selected from the group consisting of residues 129 (glutamine - »lysine), 148 (glutamic acid -» glycine) and 479 (serine - »threonine); (2) for the P gene, changes in nucleotides, which produce changes in an amino acid selected from the group consisting of residues 225 (glutamic acid -> glycine), 275 (cysteine - tyrosine) and 439 (leucine - > proline) ); (3) for gene C, changes in nucleotides, which produce changes in an amino acid selected from the group consisting of residues 73 (alanine - &valine), 104 (methionine -? - threonine) and 134 (serine - »tyrosine); and (4) for the terminal signal of the F gene (the cis-transcription termination signal termination) the change in nucleotide 7243 (T-C), wherein these nucleotides, as well as others delineated in this application (at least that is mentioned in another way), they are presented in a positive strand, an genomic, that is, in the sense of the message (encoder). In the case of subgroup B of the human respiratory syncytial virus, there is an attenuating mutation in the termination signal of the M gene (the cis-transcription termination signal) in nucleotide 4199 (T-C), where these nucleotides are presented in a positive strand, ant i genó i ca, that is in the sense of the message (coding) ). In another embodiment of this invention, these attenuated measles viruses or subgroup B of the human respiratory syncytial virus are used to prepare vaccines that produce a protective immune response against the wild-type form of each virus. In yet another embodiment of that invention, an isolated, positive-strand nucleic acid molecule, of the sense of the antigenomic message (or an isolated nucleic acid molecule, negative strand and genomic sense) having the complete viral nucleotide sequence (and either wild type virus or virus attenuated by non-recombinant means) is manipulated by introducing one or more of the attenuating mutations described in this application, to generate a measles virus or human respiratory syncytial sub-group B, attenuated, isolated, recombinantly generated. Each attenuated virus is used then to prepare vaccines that produce a protective immune response against the wild-type form of each virus.

BRIEF DESCRIPTION OF THE FIGURES Figure 1 represents the history of steps of the Edmonston measles virus (15). The abbreviations have the following meanings: HK - human kidney, HA - human mammals; CE (am) - chicken embryo; CEF chicken embryo fibroblast; DK - dog kidney; I-38 - human diploid cells; SK sheep kidney; * -cloning of plates. The number . which follows each abbreviation represents the number of steps. Figure 2 depicts a genome map of the measles virus, which shows cis-acting, putative regulatory elements in and near the terms of the genome and antigenome. Top - a schematic map of the measles virus genome, starting at the 3 'end with 52 nucleotides of leader sequence (1) and ending at the 5' end with 37 nucleotides of trailer sequence (t). The Frontier genes are denoted by vertical bars; under each gene is the number of cistronic nucleotides, Bottom - an expanded schematic view of 'the regions of the genomic promoter, extended to 3' of the genome and antigenome, showing the position and sequence of the highly conserved domains, A and B. The trinucleotide, intergenic, interventor, is denoted as such. It is presumed that the nascent 5 J RNAs, which encompass the 'a B' regions, contain the regulatory sequence in which the N protein encapsidation begins. Figure 3 represents a genetic map of wild type strains of the RSV subgroup B, designated 2B and 18537 (upper portion), the intergenic sequences of those strains (intermediate portion) and the overlap of 68 nucleotides between the M2 and L genes (lower portion). Strain 2B of RSV has six smaller nucleotides in the G gene, which encode two smaller amino acid residues in the G protein, when compared to strain 18537. Strain 2B has 145 nucleotides in trailer region 5 when compared to 149 nucleotides in strain 18537. Strain 2B has one nucleotide more in each of the genes NS-1, NS-2 and N, and a smaller nucleotide in each of the M and F genes, when compared to strain 18537. Figure 4 represents a Northern blot analysis of poly (A) + RNA, isolated from Vero cells infected with RSV subgroup A and B viruses. An autoradiograph of the transfer is shown, 1.5 hours. Strips 1-2 contain RNA isolated from cells infected with RSV subgroup A strains (lane 1, 3A, lane 2, A2). Strips 3-7 contain RNA isolated from cells infected with strains of subgroup B of RSV: lane 3, Bl; Strip 4, 2B; strip 5, 2B33F; Strip 6, 2B33F TS (+); lane 7, 18537. The transcripts of the M monois tronic gene and of the M: SH bicistronic gene are indicated by the arrows. Figure 5 depicts a ribonuclease protection assay of poly (A) + RNA extracted from Vero cells infected with wild-type virus 2B of subgroup B of RSV, mutant 2B33F and revertant 2B33F TS (+) to evaluate the ratio of mRNA M and SH monoclonal tonic with respect to the M transcripts: SH rum bicist for each virus. A 3 hour autoradiograph of the gel is shown. Fragments of protected probes are indicated by arrows. Radiolabelled RNA (M) markers were included as standard sizes: lane 1, yeast RNA minus RNase; lane 2, yeast RNA minus RNase; lane 3, 2B RNA plus RNase; fragment 4, 2B33F RNA plus RNase; lane 5, 2B33F TS + RNA plus RNase; lane 6, yeast RNA plus RNase; lane 7, yeast RNA minus RNase. A specific probe was used for RSV 2B, in strips 1-3 and 2B33F- a specific probe was used in strips 4-7. Figure 6 depicts a Northern blot analysis of poly (A) + RNA isolated from Vero cells infected with RSV subgroup A and B viruses. An autoradiograph of the transfer is presented, at 1.5 hours. Strips 1-2 contain RNA isolated from cells infected with RSV subgroup A strains (lane 1, 3A, lane 2, A2). Lanes 3-7 contain RNA isolated from cells infected with strains of subgroup B of RSV (lane 3, Bl, lane, • 2B, lane 5, 2B33F, lane 6, 2B33F TS (+), lane 7, 18537). The SH gene Tronico monocis and transcripts of the M gene: SH tronic bikes, are indicated by arrows.

DETAILED DESCRIPTION OF THE INVENTION The transcription and replication of viral genomes of single-stranded RNA, in a negative sense, are achieved through the enzymatic activities of a multimeric protein that acts in the core of ribonucleopro-tein (nucleocapsid). The naked genomic RNA can not serve as a template. Indeed, these genomic sequences are recognized only when they are fully encapsidated by the N protein within the nucleocapsid structure. It is only in this context that the sequences of the genomic and antigene end promoter are recognized to initiate the transcription or replication routes. All paramyxoviruses require the two viral proteins, L and P, for these polymerase routes to proceed. Pneumoviruses, including RSV, also require the transcription elongation factor, M2, to that the transcription route proceed efficiently. Additional cofactors may also play a certain role including perhaps the NS1 and NS2 proteins encoded by the virus, as well as perhaps also the proteins encoded by the host cell. However, considerable evidence indicates that it is the L protein that performs most, if not all, enzymatic processes associated with transcription and replication, including initiation, and termination of ribonucleotide polymerization, coronation and polyadenylation of mRNA transcripts, methylation and perhaps the specific phosphorylation of P. proteins. The central role of the L protein in transcription and genomic replication is supported by its large size, sensitivity to mutations, and its catalytic level of abundance in the viral complex t ranscripcionalmente active (16). These considerations lead to the proposition that L proteins consist of a linear array of domains whose concatenated structure integrates discrete functions (17). In In effect, three of these discrete, delimited elements within the L protein of the virus, in a negative sense, have been identified based on their connection to defined functional domains of other well characterized proteins. These include: (1) a recognition domain of the putative RNA template and / or deformation of the phosphodiester linkage; (2) an RNA binding element; and (3) an ATP binding domain. All previous studies of virus L proteins with single-stranded, negative-sense, unsegmented RNA have revealed these putative functional elements (17). Without being confined by the following, it is reasonable to presume that these non-protein encoders, promoters and other cis-acting genomic regulatory domains are important determinants of the efficiency with which transcription and replication is updated by the measles virus (MV) and other viruses of the Mononega irales Order, in the association with the L protein, and that therefore can be determinants of virulence for these viruses as such.

In summary, it is believed that the invention encompasses a set of changes in several genes of the measles virus and a cis-acting regulatory domain, and a change in a cis-acting regulatory domain of the RSV subgroup B, which results in the attenuation of each virus while retaining sufficient capacity to replicate the virus. Therefore, as part of a rational vaccine design, these mutations are introduced to provide the desired balance of replication efficiency and immunogenicity: such that the virus vaccine is no longer capable of causing disease, and that retain their ability to infect the cells of the vaccine recipient, to express sufficiently abundant genetic products to produce the full spectrum and profile of desirable immune responses, and to reproduce and disseminate enough to maximize the abundance of the immune response produced. Studies in animals have shown a decrease in viral replication, sufficient to avoid disease, but adequate to produce the immune response desired. This probably represents a decrease in transcription, a decrease in the genetic expression of virally encoded proteins, and / or a decrease in antisense templates and, therefore, the production of fewer new genomes. The resulting attenuated viruses are significantly less virulent than those of the wild type. The attenuating mutations described herein can be introduced into viral strains through two methods: (1) Conventional means such as chemical mutagenesis during virus growth in cell cultures, to which a chemical mutagen has been added, the selection of the virus that has been submitted to. passage to a temperature below the optimum temperature, in order to select temperature-sensitive and / or cold-adapted mutations, identification of the mutant virus that produces small plaques in the cell culture, and passage through heterologous hosts to select mutations in host varieties. These viruses are subsequently subjected to selective classification regarding the attenuation of its biological activity in an animal model. Attenuated viruses undergo nucleotide sequencing of their coding and intergenic regions to localize sites of attenuating mutations. Once this has been done, method (2) is carried out. (2) A preferred means of introducing attenuating mutations comprises making predetermined mutations using site-directed mutagenesis. These mutations are identified, either by method (1) or with reference to closely related viruses whose attenuating mutations are already known. One or more mutations, as defined herein, are introduced into strains of measles virus or subgroup B of RSV. Cumulative effects of different combinations of coding and non-coding changes can also be evaluated. Mutations to the N, P and / or C genes and / or to the signal of termination of the F gene, of the measles virus, or to the termination signal of the M. gene of subgroup B of the RSV are introduced through standard methods of DNA recombinant, in a DNA copy of the viral genome. This may be a wild type or modified viral genome ancestor (such as viruses modified through method (1)), thereby generating a new virus. The clones or infectious particles that contain these attenuating mutations are generated using the cDNA rescue system, which has been applied to a variety of viruses, including the Sendai virus (18), the measles virus (19), the virus respiratory syncytial (20), PIV-3 (21), the rabies virus (22), the vesicular stomatitis virus (VSV) (15), and the plague virus • bovine (23); these references are incorporated herein by reference. See, for the rescue of the measles virus, the published international patent application WO 97/06270, which designates the United States (24); for the rescue of RSV, published International Patent Application WO 97/12032, designating the United States (25); These applications are incorporated herein by reference. Briefly, all the rescue systems of the Mononegavi r a les can be summarized as follows: Each one requires a equivalent of cloned DNA, of the entire viral genome, placed between a suitable DNA-dependent RNA polymerase promoter (e.g., the T7 RNA polymerase promoter) and a self-cleaving ribozyme sequence (e.g., the delta ribozyme of hepatitis) ) that is inserted into a propagatable bacterial plasmid. This transcription vector provides the easily manipulated DNA template, from which RNA polymerase (e.g., T7 RNA polymerase) can faithfully transcribe a single-stranded RNA copy of the viral antigenome (or genome) with the 5 'and 3' terms precise or almost precise. The orientation of the viral genomic DNA copy and the flanking promoter and the ribozyme sequences determine whether the antigenome or the RNA equivalents of the genome are transcribed. Also required for the rescue of the progeny of the new virus, are the trans-acting proteins, specific to the virus, necessary to encapsidate the RNA transcripts of the antigenome or genome, viral, single-stranded, naked, in functional templates of the nucleocapsid: nuclecápside protein viral (N or NP), the phosphoprotein associated with the polymerase (P) and the polymerase protein (L). These proteins comprise the RNA polymerase dependent on the active viral RNA that must be coupled to this nucleocapsid template to achieve transcription and replication. The trans action proteins required for the rescue of the measles virus are the encapsidant N protein and the polymerase complex proteins, P and L. For the RSV, the trans specific proteins of the virus include the N, P and L, plus an additional protein, M2, the elongation factor of the transcription encoded by the RSV. Typically, trans-acting viral proteins are generated from one or more plasmid expression vectors, which encode the required proteins, although some or all of the required trans-acting proteins can be produced within the cells of subject mammals. to genetic engineering to contain and express these genes specific to the virus and its genetic products, as stable transformants.

Typical (though not necessarily exclusive) circumstances for rescue include an appropriate mammalian cell environment, in which T7 polymerase is present to drive the transcription of single-stranded, antigenomic (or genomic) RNA, from Transcription vector containing the viral genomic cDNA. Either together in transcription or briefly afterwards, this viral antigenome (or genome) RNA transcript, is encapsidated in functional templates, by the nucleocapsid protein and is coupled by the required polymerase components, produced concurrently from expression plasmids t rans fects together, which encode the trans action proteins, specific to the virus, required. These events and processes lead to the transcription of prerequisites of viral mRNAs, the replication and amplification of new genomes and, therefore, the production of a novel viral progeny, that is, rescue. For the rescue of the rabies viruses, VSV and Sendai, the T7 polymerase was provided by the recombinant vaccine virus VTF7-3. However, this system requires that the rescued virus be separated from the vaccine virus through physical or biochemical means or through repeated passage in cells or tissues that are not a good host for the poxviruses. For the rescue of the MV cDNA, this requirement is avoided when creating a cell line that expresses the T7 polymerase, as well as the viral N and P proteins. The rescue is achieved by transfecting the expression vector of the genome and the expression vector of the L gene in the auxiliary cell line. The advantages of the mutant of the host virus variety of vaccine, MVA-T7 ,. expressing T7 RNA polymerase but producing little or no infectious progeny in mammalian cells, they are harnessed to rescue RSV, rinderpest virus and MV. After the simultaneous expression of the encaps idant proteins is necessary, the viral RNAs, full-length, synthetic, viral, are replicated and transcribed by viral polymerase proteins and the replicated genomes are packaged in infectious virions. In addition to those antigenomas, genome analogs for Sendai and PIV-3 have now been successfully rescued (21, 26). The rescue system thus provides a composition comprising a transcription vector containing an isolated nucleic acid molecule, encoding a genome or antigenome of a virus with single-stranded, negative-sense, non-segmented RNA, of the order Mononegavir ale s having (a) for the measles virus, at least one attenuating mutation in the N, P or C genes or the termination signal of the F gene; and (b) for subgroup B of the RSV, at least one attenuating mutation in the M-gene termination signal, together with at least one expression vector comprising at least one isolated nucleic acid molecule encoding the trans-acting proteins , necessary for encapsidation, transcription and replication (eg, N, P and L for measles virus; N, P, L and M2 for RSV). The host cells are subsequently transformed or transfected with at least two expression vectors - just described. Host cells are cultured under conditions that allow the joint expression of these vectors in order to produce the attenuated infectious virus. The rescued infectious virus is then analyzed for its desired phenotype (sensitivity to temperature, cold adaptation, plate morphology, and attenuation of transcription and replication), first by means of a vi nt. Mutations in the N, P or C genes or in the termination signal of the F gene, of the measles virus and in the termination signal of the M gene of subgroup B of the RSV are also analyzed using the minireplicon system in which the activities of The polymerase and trans action encapsidation, required, are provided by the wild type or vaccine helper viruses or by the plasmids that express the different N, P and L genes, harboring attenuating mutations specific to the genes (19,27,83 ). If the attenuated phenotype of the rescued virus is present, challenge experiments are carried out with an appropriate animal model. Non-human primates provide the preferred animal model for the pathogenesis of human disease. These primates are first immunized with the recombinantly generated, attenuated virus, then challenged with the wild type of the virus. Monkeys are infected through several routes, including, but not limited to, the intranasal, intrathoracic or subcutaneous inoculation route (28). Rhesus monkeys and cynomolgus macaques, experimentally infected, have also served as animal models for protection studies induced by measles vaccines (29). To evaluate the attenuation levels of the RSV mutants, models of the cotton rat or mouse models can also be used (30,31). Protection is measured with criteria such as the signs and symptoms of the disease, survival, spread of the virus and antibody titers. If the desired criteria are met, the recombinantly generated, attenuated virus is considered a viable vaccine candidate for human analysis. The "rescued" virus is considered "recombinantly generated" as are the progeny and subsequent generations of the viruses, which also incorporate the mutations mitigating Even if a "rescued" virus is subatenuated. o overemphasized, • in relation to optimal levels for use as a vaccine, this is information that is valuable for developing those optimal strains. Optimally, a codon containing an attenuating point mutation can be stabilized by introducing a second plus a third mutation into the codon, without changing the amino acid encoded by the codon containing only the attenuating point mutation. Infectious virus clones containing attenuating and stabilizing mutations are also generated using the cDNA "rescue" system, described above. In one embodiment of the invention, mutations of the measles virus are evaluated, because the sequence data are now available as described herein, for the wild-type virus, which causes the disease and for the vaccines that prevent disease, which have a proven history of efficacy.

The measles virus was isolated for the first time in tissue cultures in 1954 (32) from an infected patient named David Edmonston. This strain of measles from Edmonston became the progenitor of many measles vaccines, live, attenuated, including Moraten, which is the current vaccine in the United States (At t enuvax ™, Merck Sharp &Dohme, West Point, PA) and was licensed in 1968 and has proven to be effective. Aggressive immunization programs, established in the mid to late 1960s, resulted in a precipitous drop in reported cases of measles, from about 700,000 in 1965 to 1,500 in 1983. In parallel, other strains of vaccines were developed from the strains of Edmonston (See Figure 1) Schwarz (Merieux Institute, Lyon, France), Zagreb (Zagreb, Yugoslavia) and AIK-C (Japan). These other vaccines have also proven to be effective and have been widely used. A strain of early, reactogenic, upstream vaccine (Rúbeovax MR Merck Sharp & Dohme; this may be the same as strain B of Edmonston) produced a disease similar to measles in children and therefore its use was discontinued. However, it was additionally attenuated in a successful manner to produce the Moraten vaccine strain (See Figure 1) (33). Live measles virus vaccines provide a successful story regarding the development of an effective vaccine and provide a model for understanding the molecular mechanisms of virus vaccine attenuation between viruses with single-stranded RNA, in a negative sense, not segmented Because of its significance as a leading cause of human morbidity and mortality, the measles virus (MV) has been studied quite extensively. The MV is a large, relatively spherical particle, enveloped by two compartments, a lipoprotein membrane and a ribonucleoprotein particle nucleus, each of which has different biological functions (34). The virion envelope is a plasma membrane derived from the host cell, modified by three specific proteins of the virus: hemagglutinin (H); of approximately 80 kilodaltons (kD)) and fusion glycoproteins (F?, 2; approximately 60 kD) that are projected on the surface of the virion and confer to the viral particle (16) capacities of binding and entrance to the host cells. Antibodies to H and / or F are considered protective since they neutralize the ability of the virus to initiate infection (35,36,37). The matrix protein (M); of approximately 37 kD) is the antipathetic protein that lines the inner surface of the membrane, which is created orchestrates the morphogenesis of the virion and thus consummates the reproduction of the virus (38). The nucleus of the virion contains the genomic RNA of 15,894 nucleotides long, by which template activity is conferred by its intimate association with approximately 2,600 nucleocapsid protein (N) molecules of approximately 60 kD) (39, 40, 41). Slightly associated with this particle of helical ribonucleoprot eina, of a long icron, are found enzymatic levels of the RNA polymerase dependent on the viral RNA (L, approximately 240 kD) that together with the polymerase factor (P; 70 kD) and perhaps even other specific proteins of the virus as well as other proteins encoded by the host, transcribe and replicate the genomic sequences of the MV (42). Prior to the international application PCT / US97 / 16718, the complete nucleic acid sequences (only for the Edmonston B laboratory strain and the AIK-C vaccine strain), the coding potential, and the coding potential were reported (34). organization of the MV genome. The six structural proteins of the virion are encoded by six contiguous, non-overlapping genes, which are arranged as follows: 3 '-N-P-M-F-H-L-5 Two additional MV gene products have also been identified, still of uncertain function. These two non-structural proteins, known as C (approximately 20 kD) and V (approximately 45 kD), are both encoded by the P gene, the preceding one by a second reading frame within the mRNA of P; the latter by an mRNA derived from the P gene encoded cotrans transcription 1, which encodes a hybrid protein having the amino terminal sequences of P and a new carboxy terminal domain rich in cysteine, similar to a zinc finger ( 16).

In addition to the sequences encoding the specified proteins of the virus, the MV genome contains distinctive non-protein coding domains that resemble those that direct the transcription and replication pathways of the related viruses (16,43). These regulatory signals are found at the 3 'and 5' ends of the MV genome in short internal regions that extend at each int er cis tronic border. The preceding codes encode the putative promoter and / or regulatory sequence elements that direct genomic transcription, genome and antigenome packaging, and replication. The termination of the transcription of the last signal and the polyadenylation of each viral mRNA, monocistronic, and then the restart of the transcription of the next gene. In general, the MV polymerase complex appears to respond to these signals in a manner very similar to RNA-dependent RNA polymerases, other viruses with negative-strand, non-segmented RNA (16,43,44,45). Transcription starts at or near the 3 'end of the MV genome and then it continues in a 5 'direction that produces monomeric tRNAs (41,43,46). When the polymerase crosses the genomic template of the MV, it finds putative stop / start signals that, in the order 3 'to 5' are: a termination signal of the transcription / pol iadeni ation, semi conserved (A / GU / C UA A / U NN A, wherein N may be any of the four bases) in which each monokistronic RNA is completed; a non-transcribed intergenic trinucleotide scoring mark (CUU, except at border H: L where it is CGU); and an initial start signal, for the start of the transcription of the next gene (AGG A / G NN C / A A A / G G A / U, where N can be any of the four bases) (46,47). Since some polymerase complexes fail to restart, the abundance of each MV mRNA decreases in parallel with the distance of the gene coding for the 3 'genomic end. This large amount of mRNA directly corresponds to the relative abundance of each specified protein of the virus. This indicates that the expression of the MV protein is im- mediately controlled at the level of transcription (45).

The genomic terms of the MV, 3 'and 5 A- contain non-protein coding sequences, with different parallels to the coding regions of the RNA, guidance and towing of the VSV (43). Nucleotides 1-55 define the region between the 3 'genomic term and the start of the M gene, while 37 additional nucleotides can be found between the end of the L gene and the 5' terminus of the genome. However, unlike the VSV, or even the pa ram ixo vi ru s Sendai and NDV, MV does not transcribe these terminal regions in RNA guides, sense (+) or (-) unmodified, short (48,49, fifty) . In effect, the transcripts of reading transferred, guide, include, all with full length, the polyadenylated guide: N the guide: N: P, the guide N: P: M, and of course the RNA of the MV, antigenome, of longitude complete, transcribed (49.50). In this way, the transcript guides, short, the key operative element that determines the switching of the transcription to replication of the single-stranded negative polarity genome of the VSV (51,52,53), it seems to be absent in the MV. This leads to the consideration and exploration of alternative models for this crucial reproductive event (43). The measles virus, as well as other mononegaviruses, except the rhabdoviruses, appear to have extended their terminal regulatory domains, beyond the confines of the coding and towing sequences (43). For measles, these regions encompass the 107 3 'genomic nucleotides (the 3' genomic promoter region, which is also referred to as the "extended promoter", comprising 52 nucleotides encoding the guiding region, followed by 3 nucleotides int ergeni co s, and 52 nucleotides that encode the 5 'untranslated region of N mRNA and the 109 nucleotides of the 5' end (69 encode the 3 'untranslated region of L mRNA, the intergenic trinucleotide and 37 nucleotides that code the trailer). Within these approximately 100 nucleotides of terminal 3 both of the genome and of the antigenome, there are two short regions of shared nueclot sequences: 14 of 16 nucleotides at the 3 'absolute ends of the genome and antigenome are identical. Internal to those terms an additional region of 12 nucleotides of absolute sequence identity has been placed. Their position in and near the sites in which the transcription of the MV genome should start and where the replication of the antigenome should begin, suggests that these short single sequence domains encompass an extended promoter region. These discrete sequence elements can dictate alternative sites of initiation of the transcription-the internal domain commands the initiation of transcription at the start site of the M gene and the domain of the 3 'end directs the production of the antigenome (43,49.54). In addition to their regulatory role as determinants of cis action, transcription and replication, these regions of the genomic and antigene promoter, extended to 3 A- encode the nascent 5 'ends of the genomic and antigeneomic mRNAs, respectively. Within these nascent RNAs reside, still as unidentified signals for the nucleation of protein N, another key regulatory element required for the formation of the nucleocapsid template and consequently for the amplification of transcription and replication. Figure 2 shows schematically the location and sequence of these regulatory, cis-acting, putative, highly conserved domains. The coding regions, not protein, terminal, of similar location, as well as of similar size and spacing, are present in the genomes of other members of the genus Pa ra xym or vi ri da e, through only 8-11 of their Absolute terminal nucleotides that are shared by the MV (43,55). The genomic terms of Mo rb illi vi rus, canine distemper virus (CDV) exhibit a greater degree of homology with their relative MV: 73% of the nucleotides of the guide and tow sequences of these two viruses are identical, including 16 of 18 in terms 3 Absolutes and 17 of 18 in their 5 'ends (56). No homology was found that shares the genomic domain of the CDV, internal, auxiliary, with that of the extended MV promoter. However, there is a long stretch of 20 nucleotides that lies between the genomic nucleotides of CDV 85 and 104 and 15,587 and 15,606 in which 15 of the 20 nucleotides are complementary (access number to the genetic bank AF 14953). This indicates that the CDV, like the MV, contains an additional region within its genomic and anti-genomic 3 A-noncoding ends, which can provide important regulatory signals and / or the cis-acting promoter (56). Additionally, the precise length of the 3 'guide region (55 nucleotides) is identical between several members of the Paramixoviridae family (MV, CDV, PIV-3, BPV-3, SV and NDV). Additional evidence for the importance of these protein coding regions, extended, comes from the analysis of a large number of different genomes of Backward Defective Backward Interference (DI) recently cloned from brain tissue with panence fa 1 i t i s sclerosing subacute (SSPE). No ID was found with a shorter stem than the 95 genomic nucleotides of the 5 'terminal. This indicates that the minimal signals needed for the replication and encapsidation of MV ID RNA extend far beyond the 37 nucleotide trailer sequence. long, which covers the putative, internal, additional regulatory domain (57). In all Paramyxoviruses, cis-acting signals, required for essential viral functions, include replication, transcription and encapsidation that are contained in the non-coding genomic terms. The trans action elements, mandatory for functionality, are contained in the N, P and L genes. Mutations in any of these regions can result in the alteration of vital functions, including the attenuation of the efficiency in the t rans cry ip ion / viral replication. . The potential for attenuation in the elements of the cis-acting sequence and in the trans-acting protein genes have been demonstrated in several viral systems by analyzing the sequences of their genomes (58,59). The measles mode of this invention involved an analysis of the nucleotide sequences of the isolated product of the wild-type MV, Edmonston, progenitor, along with strains of measles vaccines, available, derived from this isolated product (see Figure 1). Independently other wild type isolates were examined for comparative purposes as such. In particular, the emphasis was on the regions different to the region of the 3 'genomic promoter and the L gene; those regions were the focus of the international application PCT / US97 / 16718. The idone nucleotide sequences (in the sense of the message, antigenic, positive strand) of four wild type strains and five vaccine measles strains are presented as follows,. with reference to the appropriate Identification Sequences Numbers, contained here: Virus Nucleotide Sequence Type Wild Edmons ton SEC ID NO: 1 1977 SEQ ID NO: 2 1983 SEQ ID NO: 3 Mont efiore SEQ ID NO: 4 Rubeovax vaccine MR SEQ ID NO: 5 Morat in SEQ ID NO: 6 Zagreb SEQ ID NO: 7 AIK-C SEQ ID NO: 8 Each genome of the measles virus, listed above, has a length of 15,894 nucleotides. The translation of the N gene begins with the codon found in nucleotides 108-110; the stop codon of translation is found in nucleotides 1683-1685. The translated N protein has a length of 525 amino acids. The translation of the P gene starts. with the codon found in nucleotides 1807-1809; the stop codon of translation is found in nucleotides 3328-3330. The translated P protein has a length of 506 amino acids. The translation of gene C begins with the codon found in nucleotides 1829-1831; The translation of the stop codon is found in nucleotides 2387-2389. The translated protein C has a length of 189 amino acids. Translation of the F gene begins with the codon found in the nucleotides 5449-5451; the stop codon of the translation is found in the nucleotides 7108-7110. The translated F protein has a length of 553 amino acids. The stop / polyadenylation signal of the F gene includes a termination signal of the 11 nucleotide gene at nucleotides 7237-7247, followed by an intergenic region at nucleotides 7248-7250 and the start signal of the H gene at nucleotides 7251 -7260. Note that nucleotide 2499 of the wild type measles virus of 1983 is indicated as "G" in SEQ ID NO: 3. In effect, the base is really a mixture of "G" and "C". Also note that nucleotide 2143 of the RubeovaxMR vaccine virus is indicated as "" in SEQ ID NO: 5. In nine sequenced clones, this base was "T" in seven and "C" in two; in this way this base can be "T" or "C". In addition, the genome of the Schwarz vaccine virus is identical to the genome of the Moraten vaccine virus (SEQ ID NO: 6). An analysis of the coding and non-coding (int ercistronic) regions of the MV genome was carried out. The differences of nucleotides and amino acids, which distinguish the N, P and C gene and protein sequences, and the differences of the nucleotides, which distinguish the signal from the end of the F gene in the int eric cis / F region region of the Edmonston wild-type isolated product, vaccine strains and other wild type isolates independently isolated, were compared and aligned (See tables 3-5 in example 1 below). As shown in Table 3, there are five nucleotide changes in the N genes of the vaccine strains of the MV, compared to the wild type isolate of Edmonston, progenitor. Two of . these changes at nucleotides 275 and 623 were conservative changes that did not result in changes in the amino acid sequence. Three changes, at nucleotides 492, 550 and 1542, resulted in changes to the amino acid sequence of certain of the vaccine strains: (1) a change from a "C" to an "A" at nucleotide 492 resulted in result in a mutation of glutamine to lysine at amino acid 129 for the AIK-C vaccine strain; (2) a change of an A "one in nucleotide 550, gave as a result a mutation of glutamic acid to glycine, at amino acid 148 for the vaccine strains of Moraten and Schwarz; and (3) a change from a "T" to an "A" at nucleotide 1542 resulted in a mutation of serine to threonine at amino acid 479 for vaccine strains Rubeovax ™, Moraten and Schwarz. Because none of these three mutations were present in any of the wild-type, subsequent isolates, these three mutations of N genes are potentially attenuating in the vaccine strains. Without being enclosed by theory, the attenuating phenotype of these three M gene mutations can be based on the following analysis. Protein N must serve a number of functions in the life cycle of the measles virus. It must be able to interact with the viral genomic RNA and other copies of N to form the nucleocapsid complex in which the MV genome is always found. It interacts with the polymerase complex to allow transcription and replication. It has also been found to interact with the P protein separated from the replication complex. All these functions could be points at which mutations could result in attenuation by affecting the efficiency of virus replication. Based on the deletion analysis of Bankamp et al. (60) The changes observed in the lineage of the Edmonston vaccine fall within areas that affect the functionality of protein N as follows: (1) Changes in amino acid 129 (from glutamine to lysine in AIK-C) and at amino acid 148 (from glutamic acid to glycine in Moraten and Schwarz) both fall into a region necessary for the interaction of the N and P proteins in solution. This interaction helps maintain the N protein without aggregation in a specific manner of nucleocapsid. Protein P also serves as described, as a chaperone, by delivering N proteins to the replication genome for use in encapsidation. In the Sendai virus, the first 400 amino acids comprise a domain that is also involved in the ability to encapsidate RNA, suggesting that at least some of this region interacts with RNA. (2) The change in amino acid 479 (from serine to threonine in Rubeovax ™, Moraten and Schwarz) falls within an area that when deleted results in the formation of unstructured aggregates; this suggests that it is an N: N interaction area. This region of the carboxy terminal of the protein N has also shown in the Sendai virus, to interact with the P protein when it is assembled in the nucleocapsids. In addition, the amino acid sequence 400 at the carboxy terminus (amino acid 525) shows a markedly higher level of variation between the N proteins of the wild type MV, compared to the rest of the protein. As it is shown in. Table 4, there are three nucleotide changes in the P gene and three nucleotide changes in the C gene of vaccine strains of the MV, compared to the wild-type Edmonston isolate, parent. The first change in the '' gene at nucleotide 2480 resulted in a mutation of glutamic acid to glycine at amino acid 225 for all vaccine strains; however, this change was not present in none of the subsequent wild type isolates. This unique mutation in the protein P is in one of the amino acids of the Mobii lli vi rus, less conserved: It is glutamic acid in both wild type and vaccine strains of the rinderpest virus, and cysteine in the strains of the virus of the canine distemper and distemper (58). However, because this single mutation is common to all MV vaccine strains examined, but was not present in subsequent wild type isolates, it is observed as a potentially attenuating mutation. The P and V mRNAs share the same start codon and the first 231 amino acids of the P and V proteins are identical. V mRNA has an additional "G" between nucleotides 2498 and 2499 of P. mRNA. Editing occurs during transcription when a non-template-directed "G" residue, additional, is inserted between nucleotides 2498 and 2499, causing a shift in the reading frame, whereby the 276 amino acids of the carboxy terminal of the P protein are replaced with a carboxy terminus, rich in cysteine, 68 amino acids, of protein V. However, the amino acid 225 encoding the mutation is located before the additional "G", so that the mutation is potentially attenuating for both P and V proteins. the function of protein V is known. The second change in the P gene, from "G" to "A" in nucleotide 2630, results in a mutation of cysteine to tyrosine at amino acid 275. The third change in the gene P, in nucleotide 3122 results in a mutation of leucine to proline at amino acid 439. These two mutations were unique to the AIK-C vaccine strain - they were not present in the other vaccine strains or in some of the isolates wild type-and, therefore, are seen as potentially mitigating. The first change in gene C, from "C" to "T" at nucleotide 2046, results in a mutation of alanine to valine at amino acid 73 for all late wild type isolates, as well as for all strains of vaccines Due to the presence of this mutation in the vaccine strains, but not in the progenitor wild type strain, this mutation is seen as potentially attenuating. The next change in gene C, from "T" to "C" nucleotide 2139, resulted in a mutation of methionine to threonine at amino acid 104 for vaccine strains Rubeovax ™, Moraten and Schwarz. Because this mutation was not present in some of the wild-type, late isolates, this mutation of the C gene is potentially attenuating in the vaccine strains. The third change in gene C, from "C" to "A" at nucleotide 2229, resulted in a mutation of serine to tyrosine at amino acid 134. This mutation was unique to the AIK-C vaccine strain - no it is present in the other vaccine strains or in some of the other wild type strains-- and, therefore, is seen as potentially attenuating. The regions containing cis-acting elements, which control the start and end of transcription, for each MV gene, were found highly conserved among all the measles viruses examined.

With one exception, the sequences of the gene start and gene termination signals were identical for all viruses analyzed. However, as shown in the Table 5, there was a mutation in the F gene termination signal spanning nucleotides 7237-7247 (in the sense of the message, antigene) in two of the vaccine strains - Moraten and S chwar z - - compared with the isolated from wild-type MV, parent, with other derived vaccine strains and other wild-type isolates: at nucleotide position 7243, Moraten and Schwarz had an "A", whereas wild-type isolates and other vaccine strains had a T". This mutation in the signal of the termination of the F gene seems, it is believed, to affect the efficiency of transcription termination, which in turn could affect the expression levels of the F gene, as well as the expression of the H gene in the 3 'address. The decrease in the expression of the F and H gene are potentially responsible for the attenuation of the vaccine strains of Moraten and Schwarz. This is consistent with the suggestion that a decrease in F gene expression of the MV may be a factor in the attenuation (61). The importance of the mutations in the signals of initiation of the gene and of termination of the gene, was exemplified by the observation that a change in the start signal of the M2 gene of the RSV had a profound attenuating effect in the virus and was associated with the ts phenotype of the virus (62). Based on Table 3 and in the preceding analysis, the key attenuation sites for MV N protein are as follows: amino acid residues 129 (glutamine - »lysine), 148 (glutamic acid -» glycine) and 479 (serine - &threonine). Based on Table 4 and the preceding analysis, the key attenuation sites for the P and C proteins are as follows: amino acid residues 225 (glutamic acid - »glycine), 275 (cysteine -» tyrosine) and 439 (leucine - proline) for protein P and amino acid residues 73 (alanine - »valine), 104 (methionine -» threonine) and 134 (serine - »tyrosine) for protein C. It is understood that the changes of the nucleotides responsible for these changes in the amino acids are not limited to those presented in Tables 3 and 4 of Example 1 below; all changes in nucleotides, which result in codons that are translated into these amino acids, are within the scope of this invention. In addition, based on Table 5 and the preceding analysis, the key attenuating mutation for the termination signal of the F gene is nucleotide 7243 (T? C) (in the sense of the message, ant i genó i co). In a further embodiment of this invention, the measles virus phenotype is further attenuated by combining one or more mutations of the N, P or C gene or the F gene termination signal with one or more of each region of the genomic promoter. 3 coordinated, and mutations of the N gene, described in the international application PCT / US 97/16718, which are as follows: for the 3 'genomic promoter region of the MV, the mutations are nucleotide 26 (A -> T), nucleotide 42 (A? T or A? C) and nucleotide 96 (G-A) (in the sense of the message, antigene), whereas for protein L, the mutations are the residues of amino acids 331 (isoleucine - »threonine), 1409 (alanine -» threonine) 1624 (threonine - alanine), 1649 (arginine - »methionine), 1717 (aspartic acid - &alanine), 1936 (histidine - tyrosine), 2074 ( glutamine -> arginine) and 2114 (arginine - lysine). Again, it is understood that all changes in nucleotides, which result in codons that are translated to these amino acids, are within the scope of this invention. The human respiratory syncytial virus (RSV) is another virus with enveloped RNA, single strand, negative sense, not segmented. The RSV belongs to the Pneumovirinae subfamily and the genus Pn e um or vi r u s (see Table 1). Two main subgroups of human RSV, designated A and B, have been identified based on the reactivities of surface glycoproteins F and G, with monoclonal antibodies (63). More recently, lineages A and B of strains of RSV have been confirmed by sequence analysis (64, 65). Bovine, ovine and caprine strains of this virus have also been isolated. The specificity for the host, the virus, is in the manner most clearly associated with the binding protein G, which is highly divergent between the human and the bovine / ovine strains (66, 67) and may be influenced, at least in part, by binding to the receptor. RSV is the primary cause of serious viral pneumonia and bridging 1 i t i s in infants and young children. Serious disease, that is, lower respiratory tract disease (LRD) prevails more in infants less than six months of age. In the most common way it occurs in the first exposure of non-immune infants, to exposure to RSV. RSV is additionally associated with asthma and with hyper-reactive airways and is a significant cause of mortality in "high-risk" children with bronchial-pulmonary dysplasia and congenital heart disease (CHD). It is also one of the common viral respiratory infections, which predispose to otitis media in children. In adults, RSV usually presents as an upper respiratory disease, uncomplicated; however, in old age it rivals influenza as a factor of predisposition in the development of serious LRD, particularly bacterial bronchitis and pneumonia. The disease is always confined to the respiratory tract, except in the severe immunocompromise, where dissemination to other organs may occur. The virus spreads to others by fomites contaminated with respiratory secretions that contain the virus and the infection begins through the nasal, oral or conjunctive mucosa. RSV disease is seasonal and the virus is usually isolated only in the winter months, for example, from November to April in latitudes to the north. The virus is ubiquitous and more than 90% of children have been infected at least once around 2 years of age. Multiple strains co-circulate. There is no direct evidence of gradual antigenic displacement (such as that seen with influenza A virus) but sequence studies demonstrate the accumulation of changes in amino acids in hypervariable regions of protein G and SH proteins, suggests that the pressure immune can drive the evolution of vi rus.

In mouse and rat cotton models, both RSV and F proteins produce neutralizing antibodies and immunization with these proteins alone provides long-term protection against reinfection (68, 69). In humans, complete immunity to RSV does not develop and reinfections occur throughout life (70,71); however, there is evidence that immune factors will protect against severe disease. A decrease in the severity of the disease is associated with two or more previous infections and there is evidence that children infected with one of the two main RSV subgroups may be somewhat protected against reinfection with the homologous subgroup (72), observations that suggest that a live, attenuated virus vaccine can provide sufficient protection to prevent serious morbidity and mortality. Infection with RSV produces as many antibodies as cell-mediated immunity. Neutralizing antibodies, from serum, to proteins F and G, have been associated, in certain studies, with the protection of the LRD, although the reduction in upper respiratory disease (URD) has not been demonstrated. High antibody levels in serum in infants are associated with protection against LRD, and administration of intravenous immunoglobulin with high titers of neutralizing antibodies to RSV has been shown to protect against severe disease in high-risk children (71, 73.74). The role of local immunity, and the nasal antibody in particular, is being investigated. The virion of the RSD consists of a core of r ibonucl eopr or tine contained within a lipoprotein envelope. The virions of the pneumoviruses are of similar size and shape to those of the other paramyxoviruses. When visualized through negative staining and electron microscopy, the virions have an irregular shape and their diameter varies from 150 to 300 nm (75). The nucleocapsid of this virus is a symmetric helix similar to that of other paramyxoviruses, except that the helical diameter is 12 to 15 nm instead of 18 nm. The envelope consists of a lipid bilayer that it is derived from the host's membrane and contains surface glycoproteins, t r ansmembr an, s, virally encoded. Viral glycoproteins mediate binding and penetration and are organized separately into virion projections. All members of the paramyxovirus subfamily have hemagglutinating activity, but this function is not a defining characteristic of pneumoviruses, being absent in RSV but present in mouse Pneumovirus (PVM) (76). The activity of neuraminidase is present in members of the genera Paramyxovirus, Rubulavirus, and is absent in the Morbi 11 virus and Pneumovirus (76). The RSV has two groups, designated A and B. The wild type RSV genome (strain 2B) is a single strand of negative sense RNA, of 15,218 nucleotides (SEQ ID NO: 9) that are transcribed into ten subgenomic mRNAs, principal, which encode eleven genetic products. Each of the ten mRNAs encode a major polypeptide chain: Three are transmembrane surface proteins (G, F and SH); three are proteins associated with RNA genomic to form the viral nucleocapsid (N, P and L); two are non-structural proteins (NS1 and NS2) that accumulate in infected cells but are also present in the virion in trace amounts and may play a role in the regulation of transcription and replication; one is the protein of the non-glycosylated virion matrix (M); and the last one is M2, another non-glycosylated protein shown recently, is a transcription elongation factor specified for RSV (See Figure 3) (another genetic product is also encoded by the M2 gene). These ten viral proteins represent almost the entire viral coding capacity. The viral genome is encapsidated with the main protein of the nucleocapsid (N) and is associated with the phosphorus (P) and the large polymerase protein (L). These three proteins have proved to be necessary and sufficient to direct RNA replication of RSV minigenomes encoded by cDNA (77). Additional studies have shown that M2 protein (ORF 1) is required for complete transcription to take place. (75). When M2 protein is missing, truncated transcripts predominate and full-length genome rescue does not occur (75). Both the M protein (matrix protein) and the M2 protein are internal virion associated proteins that are not present in the nucleocapsid structure. By analogy with other viruses with negative, non-segmented RNA, it is believed that the M protein causes the nucleocapsid to be critical and inactive before packaging and mediates its association with the viral envelope. The NS1 and NS2 proteins have been detected only in small amounts in purified virions, and up to now they are considered non-structural. Their functions are uncertain, although they can be regulators of transcription and replication. Three surface glycoproteins are present in the virions: the G, F and SH. G and F (fusion) are envelope glycoproteins that are known to mediate the binding and penetration of the virus into the host cell. In addition, these glycoproteins represent the first independent immunogens (78). The function of the SH protein is unknown, although a recent report has implicated its involvement in the fusion function of the virus (79). As discussed above, the genomes of two strains of wild type RSV subgroup B (2B and 18537) were subjected to full sequencing, as described in the international application PCT / US9716718 (see SEQ ID NOS: 9 and 10). Genomic RNA is neither crowned nor polyadenylated (80). Both in the virion and intracellularly, the genomic RNA is closely associated with the N-protein. The 3 'end of the genomic RNA consists of an extragenic guide region of 44 nucleotides, which is presumed to contain the main viral promoter (FIG. 3) . The region of the 3 'genomic promoter is followed by ten viral genes in the order 3' -NS 1 -NS 2 -N- P-M-SH-G-F-M2-L-5 '(Figure 3). The L gene is followed by an extragenic tow region of nucleotides 145-149 (see Figure 3). Each gene begins with a start signal of the gene, of nine conserved nucleotides, 3'-GGGGCAAAU (except for the start signal of the gene, of ten nucleotides, of the L gene, which is 3 '-GGGACAAAAU; and the start signal of the SH gene for 2B and 18537, which is 3 '-GGGGUAAAU; where the differences are underlined). For each gene, transcription starts at the first nucleotide of the signal. Each gene ends with one end of the gene of 12-14 nucleotides, semi-preserved (3'-AGU / GU / A ANNN U / A A3_5) (where N can be any of the four bases) that directs the termination of transcription and polyadenylation (Figure 3). The first nine genes are non-overlapping and are separated by intergenic regions whose size varies from 3 to 56 nucleotides for strains .B of RSV (Figure 3). The intergenic regions contain no conserved motifs or any obvious characteristics of the secondary structure and have been shown to have no influence on the preceding and succeeding gene expression in a minireplicon system (Figure 3). The last two RSV genes overlap by 68 nucleotides (Figure 3). The start signal of the gene, of the L gene, is located within, rather than after, the M2 gene. This overlap sequence of 68 nucleotides encodes the last 68 nucleotides of the M2 mRNA (exclusive of the poly-A tail), as well as the first 68 nucleotides of the mRNA of L. ten different polyadenylated, subgenomic mRNA species and a certain number of transcribed, transcribed, polyadenylated transcripts s, tronic pol ici s, are the products of genomic transcription (75). Transcriptional mapping studies, using genomic inactivation mediated by UV light, showed that RSV genes are transcribed in their order of 3 'to 5' from a single promoter near the 3 'end (81). In this way, the RSV synthesis seems to follow the sequential, single-entry transcription model proposed for all Viral Mononega (16, 82). According to this model, the polymerase (L) makes contact with the genomic RNA in the nucleocapsid form, in the region of the 3 'genomic promoter and begins the transcription in the first nucleotide. RSV mRNAs are colinear copies of the genes, with no evidence of editing or cleavage of the mRNA. The intracellular RSV mRNA sequence analysis showed that the synthesis of each transcript begins at the first nucleotide of the start signal of the gene (75). The 5 'end of the mRNAs are topped with the structure m7G (5') ppp (5 ') Gp (where G underlined is the first nucleotide template of the mRNA) and the mRNAs are po 1 iadeni 1 at their ends 3 '(83). It is believed that both of these modifications are made transcriptionally together, by the viral polymerase. It has been found that three regions of the 3 'genomic promoter of RSV are important as cis-acting elements (84). These regions are the first ten nucleotides (which presumably act as a promoter), nucleotides 21-25, and the start signal of the gene located at nucleotides 45-53 (84). Unlike other Paramixovi r inae, such as measles, Sendai and in PIV-3, the rest of the guide and non-coding region, of the NS1 gene of RSV, was found to be highly tolerant of insertions, deletions and substitutions. (84). Additionally, by saturation mutagenesis (where each base is independently replaced by each of the other three bases and compared to analyze the efficiencies of translation and replication) within the first 12 nucleotides of the region of the genomic promoter 3 it was demonstrated that a stretch in U located at nucleotides 6-10 was quite intolerant of substitutions (84). In contrast, the first five nucleotides were relatively tolerant to a certain number of substitutions and two of them in position four were ascending regulatory mutations, which resulted in a 4 to 20-fold increase in the replication and transcription of RSV-CAT RNA. Using a bicistronic minireplicon system it was shown that the motifs of gene initiation and gene termination were signals for mRNA synthesis and appear to be autonomous and largely independent of the nature of the attached sequence (85). The start signal of the L gene is 68 nucleotides downstream of the M2 gene termination signal, resulting in a genetic overlap (Figure 3) (75). The presence of the termination signal of the M2 gene within the L gene results in a high frequency of premature termination of the transcripts of the gene L. L mRNA, full-length, is much less abundant and occurs when the polymerase fails to recognize the motif at the end of the M2 gene. This results in a much smaller transcription of the L mRNA. The overlapping of genes seems incompatible with a linear sequential transcription model. It is not known if the polymerase leaving the M2 gene jumps back to the start signal of the L gene or if there is a second internal promoter for transcription of the L gene (75). It is also possible that the L gene is accessed by a small fraction of polymerases that fail to initiate transcription in the start signal of the M2 gene and that slide down the M2 gene towards the start signal of the L gene. The relative abundance of each RSV mRNA decreases with the distance of its gene from the promoter, presumably due to the polymerase release during sequential transcription (81). Gene overlap is a second mechanism that reduces the synthesis of full-length L mRNA. Also, certain mRNAs have characteristics that could reduce the efficiency of translation. The codon of start for the SH mRNA is in a context of suboptimal Kosak sequence, whereas the G ORF starts at the second methionyl codon in the mRNA. It is believed that the replication of RSV RNA (75) follows the model proposed by studies with the vesicular stomatitis virus and the Sendai virus (16, 82). This involves a change from the stop-start mode of mRNA synthesis to a transfixed anti-erroneous reading, resulting in the latter in the synthesis of replication intermediate RNA (Rl) which is an exact complementary copy of the genomic RNA. This in turn serves as the template for the synthesis of progeny genomes. The mechanism involved in the. change to anti-erminator mode, is • proposed thinking that it involves the encapsidation of the cotrans cripcional nascent RNA by protein N (16, 82). The replication of RNA in RSV, as in other viruses with negative-strand, non-segmented RNA, is dependent on -the synthesis of proteins, in progress (86). The Rl RNA predicted has been detected for the standard virus as well as for the RSV-CAT minigenome (75, 86). RNA from Rl was 10 to 20 times less abundant intracellularly than was the progeny genome, both for the minigenome system and for the standard. The RSV subgroup B modality of this invention involved an analysis of the nucleotide sequence of several wild type vaccines and revertant RSVn strains. In particular, the emphasis was on regions different to the region of the 3 'genomic promoter and the L gene; those regions were the subject of the international application PCT / US 97 / 16718. The nucleotide sequences (in the sense of the message, antigenic, positive-strand) of several wild-type vaccines and strains of subgroup B of the revertive RSV, are presented as follows, with reference to the appropriate SEQ ID numbers contained herein: Vi rus Sequence Length of the Wild type of Nucleotide genome 2B SEQ ID NO: 9 15218 18537 SEQ ID NO: 10 15229 Vaccine 2B33F SEQ ID NO: 11 15219 2B20L SEQ ID NO: 12 15219 Revertant 2B33F TS (+) SEQ ID NO: 13 15219 2B20L TS (+) SEQ ID NO: 14 15219 The translation of the M gene starts with the codon found in nucleotides 3262-3264; the stop codon of translation is found in nucleotides 4030-4032. The translated protein M is 256 amino acids in length. The stop / polyadenylation signal of the M gene includes a termination signal of the gene, twelve nucleotides, in nucleotides -4196-4207, followed by an intergenic region in nucleotides 4208-4216 and the start signal of the SH gene in the nucleotides 4217-4225. An analysis of the coding and non-coding (intercistronic) regions of the genome of subgroup B of RSV was carried out. • Differences were made between nucleotides and amino acids that distinguish Protein and SH gene sequences, and nucleotide differences that distinguish the M gene termination signal in the M / SH inter-cis region of several wild type vaccines and RSV strains, revertants (see tables 6, 7 and 9). in later example 2). The regions containing the cis-acting elements that control the termination of the transcription for each gene, were found to be highly conserved among all the RSV subgroup B viruses examined. As an exception, the sequences of the start signals of the gene and the end of the gene were identical for all viruses analyzed. The third nucleotide of the termination signal of the M gene of wild type 2B, the vaccine 2B33F and the revertant strains 2B33F TS (+) was a G, while the third nucleotide of all the other signals of the end of the subgroup B gene of the RSV, was a T. More importantly, as shown in Table 7, there was a mutation in the M gene termination signal spanning nucleotides 4196-4207 in type 2B virus wild (in the sense of the message, antigenomic) and encompassing nucleotides 4197-4208 in the vaccine strain 2B33F and in the revertant strain 2B33F TS (+): At the position of nucleotide 4199, the wild type virus 2B had a that strains 2B33F TS (+ and 2B33F had a "C" at the position of the corresponding nucleotide 4200 (these strains have an additional nucleotide in their regions of the 3 'genomic promoter). This mutation was not present in any of the wild-type strains 18537, or the vaccine strain 2B20L or its revertant strain TS (+). As shown in Table 11 and Figures 4-6, the sequence of the M gene termination signal impacts the expression of the SH gene. The mutant 2B33F of subgroup B and its revertant TS (+) has this unique nucleotide in this fourth position of the termination signal of the M gene at nucleotide 4200 in the mutant and revertant) that is not found in its precursor strain 2B (in nucleotide 4199) or in any of the other viruses of subgroup B or A of RSV, analyzed. As the analysis of Northern blot (Figures 4 and 6) and a ribonuclease protection assay (Figure 5) which are discussed in later examples, wild type strain 2B produced a slight excess of M: SH bicistronic relative to the monocistronic M transcripts. In contrast, the mutant 2B33F and its revertant 2B33F TS (+) produced the M and SH transcripts practically non-monocistronic; in fact, most of its transcription products were transcribed reading transpired, st ronic bike and higher molecular weight. These rhombic and read-through bicist transcripts are likely to be considered for their ability to translate the SH gene product. In this way, the strains containing this mutation have a down regulated SH expression, as compared to the precursor strain 2B, and have essentially stopped producing the SH protein. This shift towards the predominance of rhombic transcription products and the concomitant down-regulation of the downstream gene product, SH, provides evidence that the mutation in the M-gene termination signal contributes to the Attenuation phenotype of these two strains. Therefore, based on Tables 6-11, Figures 4-6 and the foregoing analysis, the key attenuating mutation for the M gene termination signal is nucleotide 4199 (T - » C) (in the sense of the message, ant i genómi co). It is interesting to note that the SH gene of mutant 2B33F is marked with nucleotide changes (deviated hypermut) compared to precursor 2B (see Table 6), some of which would have resulted in amino acid substitutions in the SH protein. A change in nucleotide 4498 of 2B33F converts the stop codon of the SH translation, predicted, into glutamine. This results in a predicted length, for protein 2B33F SH, which is substantially longer than that of precursor 2B. In a further embodiment of this invention, the phenotype of RSV subgroup B is further attenuated by combining the mutation of the M gene termination signal, referred to above, with one or more of each of the regions of the genomic promoter. 3 coordinates, and mutations of the L gene, described in the international application PCT / US97 / 16718, which are as follows: for the 3 'genomic promoter region of the RSV subgroup B, the mutations are nucleotide 4 (C-G), and the insertion of an additional A in the stretch of A, at nucleotides 6-11 (in the sense of the antigenic message), whereas for protein L the mutations are amino acid residues 353 (arginine - »lysine) 451 (lysine - > arginine) , 1229 (aspartic acid - »asparagine), 2029 (threonine - > isoleucine) and 2050 (asparagine -» aspartic acid). Again, it will be understood that all changes in nucleotides that result in codons that are. translated into these amino acids, they are within the scope of this invention. When the region of the 3 'genomic promoter is modified by the insertion of an additional A in the stretch of the A, in nucleotides 6-11, it is understood that the attenuating mutation in the M gene termination signal will be in the nucleotide 4200 instead of at nucleotide 4199. The attenuated viruses of this invention exhibit a substantial reduction in virulence, compared with wild type viruses that infect human and animal hosts. The degree of attenuation is such that the symptoms of the infection will not arise in the majority of the immunized individuals, but the virus will retain sufficient competence for replication, to be infectious in, and to produce, in the vaccinated, the immune response profile, wanted . The attenuated viruses of this invention can be made to formulate a vaccine. By doing so, the attenuated virus is adjusted to an appropriate concentration and formulated with any suitable adjuvant, diluent or carrier for the vaccine. Physiologically acceptable media can be used as carriers. These include, but are not limited to: an appropriate isotonic medium, saline regulated with phosphates and the like. Suitable adjuvants include, but are not limited to, MPLMR (3-O-deacylated monophosphoryl lipid A, RIBI ImmunoChem Research, Inc., Hamilton, MT) and IL-12 (Genetics Institute, Cambridge, MA). In an embodiment of this invention, The formulation that includes the attenuated virus is intended to be used as a vaccine. The attenuated virus can be mixed with cryoprotective additives or stabilizers such as proteins (eg, albumin, gelatin), sugars, eg, sucrose, lactose, sorbitol), amino acids (eg, sodium glutamate), saline or other agents protectors This mixture is kept in a liquid state, or is subsequently dried or lyophilized for transport and storage, and mixed with water immediately before administration. The formulations containing the entertained viruses of this invention are useful for immunizing a human or animal subject, to induce protection against infection by the wild type counterpart of the attenuated virus. Thus, this invention further provides a method of immunizing a subject, to induce protection against infection by a virus with RNA, of the Mononegavirales Order, by administering to the subject an effective immunizing amount, of a vaccine formulation that incorporates one version attenuated from that virus, as described hereinabove. - A sufficient amount of the vaccine, in an appropriate number of doses, should be administered to the subject to produce an immune response. Those skilled in the art will readily be able to determine those amounts and dosages. Administration can be through any conventional effective form, such as intranasally, parenterally, orally, or applied topically to any mucosal surface such as the intranasal, oral, ocular, pulmonary, vaginal or rectal surface, such as by a sprayer of spray. The preferred means of administration preferred for administration is through intranasal administration. With respect to the international application PCT / US 97/16718, applicants deposited samples of the Moraten measles virus vaccine strain, on August 21, 1997, at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852 , United States of America, under the provisions of the Budapest Treaty for the Deposit of Microorganisms, for the purposes of Patent Procedures ("Budapest Treaty") and were assigned the number ATCC VR2587, and samples of RSV wild type 2B virus were also deposited by the applicants , August 21, 1997, at the American Type Culture Collection, 12301 Parklawn Drive, Rockville, Maryland 20852, United States of America, under the provisions of the Budapest Treaty and assigned the access number ATCC VR2586. Given these two deposited strains and the sequence information for these and other strains provided herein, site-directed mutagenesis and rescue techniques, described above, can be used to introduce mutations (or to re-establish a wild-type genotype) of all the strains described herein, as well as taking these strains and carrying out additional mutations from the panel of mutations presented in Tables 3-11 below. In order that this invention may be better understood, the following examples. The examples are for the purpose of illustration only and should not be considered as limiting the scope of the invention.

Examples Standard techniques of molecular biology were used, according to the protocols described in Sambrook et al. (87).

Example 1 Measles The MV Moraten vaccine virus was once cultured. directly from the AttenuvaxMR vaccine vial (Lot # 0716B), the Schwarz vaccine virus, once (Lot 96G04 / M179 G41D), while the Zagreb and RubeovaxMR vaccine viruses were cultured twice in Vero cells, before the RNAs were produced for sequence analysis. The isolated wild-type product of the MV, Montefiore (57), was passed from 5 to 6 times in Vero cells before the extraction of the RNA materials and similarly, the wild type isolates of the MV, 1977, 1983 (14) were cultured 5-7 times before extracting the materials for analysis. The Edmonston wild type isolated product, received by Dr. J. Becker (CBER) (see Figure 1) was the original Edmonston isolate, already seven times in human kidney cells and three times in Vero cells, before the reception, and were additionally passed once in Vero cells before being used for sequence analysis. The RNA was prepared by infecting Vero cells at a multiplicity of infection (m.o.i.) from 0.1 to 1.0 and the maximum cytopathy was allowed to reach before being harvested. The RNA of the cells infected with the measles virus was extracted using the Trizol ™ reagent (Gibco-BRL). The total RNA isolated from the material passed through Vero cells was amplified by the trans crypt-a-PCR method (Per kin-Elmer / Ce tus) using pairs of specific measles primers (B Edmonston strain) (19)) encompassing the 3 'and 5' promoter regions and the L gene of the viral genome. Table 2ese sequences of primers. The primers of SEQ ID NOS: 15-34, 54, 57 and 58 are in the sense of the antigenomic message. The primers of SEQ ID NOS: 35-53, 55, 56 and 59 are in the negative genomic sense.

Table 2 Primers for PCR and L gene sequencing of MV and genomic terms 9047CATATCACTC! ACTCTGGGATGGAG907a (SEQ ID NOtl5) Í371TCAGAACATCAAGCACCGCCM9)} (SEQ ID NO: 16) 9741ACAGTCAAGACTGAGATGAG9760 (SEQ ID NO: 17) 10001AAGAGTCAGATACATGTGGA10020 (SEQ ID NO: 18) 103saACATGAATCAGCCTAAAGTC1C370 (SEQ ID NO: 19) XDS74CCGAAAGAGTTCCTGCGTTACGACC10S., (SEQ ID NO: 20) 110S3 CAGTCCACACAAGTACCAGG. 11102 (SEQ ID NO: 21) iGTCAGAAGCTGTGGAGCATC meo (SEQ ID NO: 22) 11841J AATATTGCTACAACAATGGC naso (SEQ ID NO: 23) i2iísA.CTCTTCATTCCTAGACTGGlaJ15 (SEQ ID NO: 24) 12S42GTCCAATTATGACTATGAAC12SS1 (SEQ ID NO: 25) 12891AGAACAGACATsAAGCTTGC 1.2910 (SEQ ID NO: 2) 13232CCAACAAGGAATGCTTCTAG_1_.32S1. { SEQ ID NO: 27) 13551ACAGCACTATCTATGATTGACCTGG13575 (SEQ ID NO: 28) 139? 0G RACATGGTTTACACATGC13949 (SEQ ID NO: 29) 14I29AGGAGATACTTAAACTAAGC14648 (SEQ ID NO: 31) 14 TAAGCTTATGCCTTTC? GCG15000? SEQ ID NO: 32) ls337T AACGGACCTAAGCTGTGC153Sg (SEQ ID NO: 33) «71 GAAACAGATTATTATGACGG 'Ü, ÍSO (SEQ ID NO: 34) 9290CGGGCTATCTAGGTGAACTTCAGG92ß7. { SEQ ID NO: 35) 9S00ATTTGGATATGGAATATGAG94S1 (SEQ ID NO: 36) sa40ACTCAACTGAACTACCAGTG 9, 821 (SEQ ID NO: 37) 10181- AAGAACATCATGTATTTCAG 1Q1S2 (SEQ ID NO: 38) 1054, TTATCAACGCACTGCTCATG10S30. { SEQ ID NO: 39) 10J19 A 'TTTTCAGCAATCACTTGGCATGCC 1.08SS (SEQ ID NO: 0) 112 aoGCCTCTGTGCAAACAAGCTG112S (SEQ ID NO: 41) 11 $ 38TCTCTAGTTACTCTAGCAGCn519 (SEQ ID NO: 42) i2010AGGTCsTTGTTTGTGAGGAG119 > l (SEQ ID NO: 43) 12361 TCGTCCTCTTCTTTTACTGTCi (SEQ ID NO: 44) -CCGTCCTCGAGCTAGCCTCG. (SEQ ID NO: 45) 13052CTCCTCCAGGCTCACATTGG13033 (SEQ ID NO: 46) 13420GGG TGGTACATAGCTCTGC13401 (SEQ ID NO: 47) 137e7CACCCATCTGATATTTCCCTGATGG13743. { SEQ ID NO: 48) 14099TGGTTGACAGTACAAATCTsi40í0 (SEQ ID NO: 9) 144SOCTGAAATGGGAAGATTGTGC14441 (SEQ ID NO: 50) 14a20AGCAATCTACACTGCCTACC14i01 (SEQ ID NO: 51) 1S1S0TCACAGATGATTCAATTATC1S1Í1 (SEQ ID NO: 52) 13S30 G'- ATCCTAGATATAAGTTCTC ", 15511 (SEQ ID NO: 53) iACCAAACAAAGTTGGGTAAGG-! (SEQ ID NO: 54) GGGGGAtCCaooATCCCTAATCCTGCTCTTGTCCC7s (SEQ ID NO: 55) jooGATTCCTCTGATGGCtCCAC -j1 * 1. { SEQ ID NO: 56) 1S721 TAACAGTCAAGGAGACCAAA '1S741 (SEQ ID NO: 57) GGGAAsCTT15? 01AACCCTAATCCTGCCCTAGGTGG15823 (SEQ ID NO: 58) 1539-4 ACCAGACAAAGCTGGGAATAGA L15873 (SEQ ID NO: 59) The overlapping PCR fragments, of the whole viral genome, were sequenced directly without cloning, to achieve the consensus sequence, by the method of sequencing of the dideoxy terminator cycle, using both strands (the AB1 PRISM sequencer and the AB1 PRISM sequencing kit). To determine the sequence in absolute terms, a ligation procedure previously described (56) was used. The nucleotide sequences were determined for regions other than the region of the genomic promoter and the L gene of the wild type Edmonston MV isolated product, parent, for the available vaccine strains derived from this isolated product, as well as for other type strains. wild. Significant differences between nucleotides (in the sense of the message, antigenomic) and amino acids, were then compared and aligned as presented in Tables 3-5 (the differences are in italics): Table 3 Differences in the N nucleotides and amino acids, of the MV, between the vaccine and wild type strains of Edmonston Nucleotide 275 492 550 623 1542 Edmonston GTC CAA GAG GCC TCG (type s il ves t re) Mutation GTG AAA GGG GCT ACG Amino acid 56 129 148 172 479 Edmons ton V Q E A S (type s i 1ve s t re) Vac. V Q E A T RubeovaxMR - Vac. V Q G A T Moraten Vac. Schwarz V Q G A T Vac. Z add V Q E A s Vac. IK-C V K E A s Table 4 Differences in nucleotides and amino acids P and C of the MV, between the vaccine and wild type strains Gen C C C P * P P Nucleotide 2046 2139 2229 2480 2630 3122 Edmonston GCC ATG TCT GAG TGT CTA (type s ilves t re) Mutation G TC ACG TAT GGG TAT CCA Amino acid 73 104 134 225 275 439 Ed ons t on A M S E C L (wild type) 1977 V M S E C L (type s il e s t re) 1983 V M S - E C L (t ipo s ilves t re) Monte fiore V M S E C L (wild type) Vac. RubeovaxMR V T S G C L Vac. Moraten V T S G C L Vac. Schwarz V T S G C L Vac. Zagreb V M S G C L Vac. AIK-C V M Y G Y P * Identical change in protein V Table 5 Differences in the signal of termination of the F gene of the MV, between the strains of vaccine and wild type of Edmonston Nucleotides 7237-7247 Edmonston (wild type) G T T A A T A A A Vac. Rubeovax .M1 R G T T A A T A A A Vac. Moraten G T T A A C A A A Vac. Schwarz G T T A A T C A A A Vac. Zagreb G T T A A T A A A Vac. AIK-C G T T A A T A A A T 7243 Example 2 Subgroup B of the RSV The temperature-sensitive genotype (ts) is strongly associated with in vivo attenuation; in addition, some mutations not sensitive to temperature can also be attenuating.

The identification of attenuating mutations Temperature sensitive or non-temperature sensitive were achieved by sequence analysis and evaluation of temperature sensitive phenotypes, adapted to cold (ca), and subject to the growth of mutants and revertants of RSV. The genomes of the following three strains 2B of the RSV, have been completely sequenced: The wild-type precursor 2B, a temperature-sensitive and cold-adapted derivative thereof, designated 2B33F and a temperature-sensitive revertant (+) designated 2B33F TS (+). Strain 2B33F is described in US Patent Serial No. 08 / 059,444 (88), which is incorporated herein by reference. After identifying the regions where the mutations are located in 2B33F, nine additional isolated products of the "revertants" 2B33F, obtained following the step in vi tro at 39 ° C and through the passage in green monkeys of Africa or in chimpanzees, they have been sequenced in those regions of mutants - previously identified. The temperature-sensitive phenotypes, adapted the cold, and attenuation, of many of these revertants, have now been characterized and evaluated. The correlations between the temperature-sensitive phenotype, the attenuation of the virus and the changes in the sequence have been identified. A summary of the results is presented in tables 6-11.

Table 6 Comparison of sequences between strains 2B and 2B33F of RSV For the 2B33F and 2B33F S (+), the position numbers of the nucleotides are one longer than pair to 2B for the M, SH, and L genes. At position 9853, the Lys-Arg change has been reversed I reissued Lys in strain 2B33F TS (+).

Table 7 Differences in the M gene termination signal between strains 2B and 2B33F of the RSV t Table 8 Strains 2B, ts and RSV Reverters H O ro Table 8 (continued) Strains 2B, ts and RSV Reverters O? total) ND = not done; T. Silv. = Wild type; plate size: sp = small plate size; int = intermediate plate size s D _o_s.i.s. = 106-7 PPFFUU IINN b to DDoossiiss = 10 5T6 PFU IN c Dose = 106-3 PFU IN 10 d Dose = 105-9 PFU IN e Dose = 106.6 PFU IN + IT f Dose = 106-0 PFU + IT Table 9 Reversants 2B33F ts (+) In vitro AGM Chimpanzees 5a 4a 3b pP2 pp4 pp6 pp7 ÍA 3A 5A base no. t M 4176,4200 S S S S S S S S S SH 14 bases * S S S S S S S S S S L 9560 S S S S S S S S S S 9854 2B 2B 2B S S S 2B 2B 2B 12187 S S S S s S S S S S 14588 S S S S s S S S S S 15072 s S S S s s s S S s Phenotype ts 2B 2B 2B r r s s 2B 2B 2B ca - S S 2B S 2B S ND ND ND Attenuated r r r (r) (r) S S N D r r t These base numbers of the 2B33F revertants are one longer than for 2B, for the M, SH and L genes. * bases 4330, 4410, 4421, 4443, 4455, 4485, 4498, 4506, 4526, 4527, 4543, 4562, 4576, 4599 S = same base as for 2B33F 2B = reversion to base 2B or complete reversion in the r phenotype = moderate reversion in the phenotype (r) = slight reversion in the ND phenotype = not realized Table 10 Strains 2B, ts, and RSV reverts: Summary of phenotypes Table 10 (continued) Strains 2B, ts and RSV reversals Summary of phenotypes ND = not performed = wild type phenotype, that is, not sensitive to temperature, not adapted to cold, not attenuated, from + to ++++ = increasing levels of sensitivity to temperature, adaptation to cold or attenuation Northern blot analysis of the isolated product of poly (A) + RNA from Vero cells infected with RSV, was performed using a mixture of 32P-labeled riboprobes specific for the M gene of the RSV subgroup A and B viruses, for To determine the effect of the sequences of the M gene termination signal on the transcription of the M gene. The negative sense hybridization probes were the RNA polymerase transcripts, T7, synthesized in vi t ro from PCR products containing the sequence of the T7 promoter. As shown in Figure 4, Northern blot analysis, using probes of the M gene, represented abundant transcripts of the monocistronic M gene, for the viruses, of the RSV subgroup A, while the transcripts M: SH bi ci st róni eos were predominant for subgroup B viruses. The M: SH bi ci st róni e transcripts may probably have restricted their ability to translate the SH gene and thus represent a potential means to control the expression of the viral SH gene. Strains of mutant 2B33F (lane 5) and revertant 2B33F TS (+) (lane 6) produced practically no monocistronic M transcripts; most of its transcription products were higher-molecular-weight, trans-bis cross-readed transcripts. In this way, these two strains have essentially stopped producing the SH protein. In contrast, strains 2B, Bl and 18537 of wild type subgroup B produced a slight excess of bicistronic mRNA relative to monocistronics (stripes 3,4,7). The 3A viruses of subgroup A showed comparable levels of monokistronic and rhombic bicist products (lane 1). At the other extreme of what was observed for mutant strains 2B was the transcription pattern of the M gene of the A2 virus (strip 2). For this strains, monocistronic M transcripts were produced in abundance, while the transcribed reading transcript was minimal. The results of the Northern blot were confirmed by a ribonuclease protection assay, which was performed on the same poly (A) + RNA that was used for the Northern Blot, in order to evaluate the proportion of M and SH mRNAs, monocistronic, with respect to M: SH bicistronic for each virus of subgroup B of RSV. Riboprobes were used that were transcribed with 32 P-labeled, negative sense, 284 nucleotides in length (B viruses) that spanned the M: SH gene junction. The full-length probe should be protected from RNase digestion predominantly by the M: SH bi ci s t róni e transcripts. It is expected that the monoistronic M and SH transcripts protect approximately 165 and 110 nucleotide probe fragments, respectively, from RNase digestion. In an assay for the viral RNA of 2B, 2B33F and 2B33F TS (+) shown in Figure 5, viral RNA or control yeast RNA, was hybridized with 5 X 104 cpm of the probe; subsequently, the hybridized RNA was digested with RNase TI (diluted 1: 100), precipitated with ethanol, and the fragments of protected probes were separated on a denaturing 6% polyacrylamide gel. The results of this ribonuclease protection assay are represented in the Figure 5. In this test, the signal intensity of the protected probe fragment corresponding to the M: SH bicistronic, relative to the monocistronic M, for each virus, was in agreement with the results obtained by the Northern blot with the probes of the M gene. , ie, greater mono-ion signal for 2B and practically no monocistronic signal for 2B33F and 2B33F TS (+) (Figure 5). To evaluate the influence of the M gene termination signal, in the expression of the SH gene located in the 3 'direction, a Northern blot analysis of poly (A J + RNA of the RSV viruses, using riboprobes labeled with negative sense 32P, specific for the SH gene was carried out. of a strain of subgroup A and B of the RSV, to evaluate the influence of the GE signal of M on the expression of the SH gene in the 3 'direction (see Figure 6) .The pattern of the transcripts of the SH gene, produced by each virus, that is, the level of monocistronic SH to M: SH bicistronic, was comparable with that observed for the transcription products of the M gene.

RSV, which were inefficient in terminating the transcription of the M gene in the Ngen M termination signal, were also involved in the synthesis of the monocistronic SH transcripts. The mutant 2B33F and its revertant TS (+) practically did not synthesize monocistronic product, but accumulated abundant M: SH transcripts. Wild type viruses 3A, 2B, Bl and 18537 accumulated comparable levels of both transcription products, while strain A2 produced monocistronic SH mRNA, as the most abundant product of transcription of the SH gene. The transcripts identified by Northern blot analysis were quantified by analysis with the phosphor imaging agent and a relative ratio of SH monocistronic to M: SH bicistronic was determined for each virus. As shown in Table 11, the proportions ranged from 0.23 to 11.1, and the lowest values observed for RSV subgroup B strains containing the mutation in the fourth nucleotide (T - »C) of the RSV termination signal. M gene: Table 11 Proportion of monocistronic SH to M: SH bicistronic Transcripts in strains of subgroup A and B of RSV Vi rus SH / M: SH 2B 1.4 2B33F 0.23 2B33F TS (+) 0.29 Bl 1.0 18537 0.76 A2 11.1 3A 2.2 Many significant observations can be extracted from these data: As shown in Table 6, there are relatively few sequence changes identified in the mutant strain: RSV 2B33F differs from parent RSV 2B, by two changes in the region of the RSV. genomic promoter 3 two changes in the 5 'non-coding end of the M gene, including one in the M gene termination signal, and four coding changes plus one non-coding change (poly (A) motif) in the RNA-dependent RNA polymerase encoding the L gene. In addition, 14 changes map to the SH gene alone. An attenuating mutation in the M gene termination signal of the attenuated virus strain 2B33F can be identified: The displacement from a slight excess of bike streptococcal mRNA, relative to the monocistronic ones, in the wild-type strain 2B, with respect to the The predominance of the transgenic products of the stróni eos bike in vaccine strain 2B33F and in the revertant strain 2B33F TS (+) provides evidence that the mutation in the M gene termination signal contributes to the attenuation phenotype of these last two viral strains. .

Bibliography I. Kapi ian, A.Z., et al., Am. J. Epidemol., 89, 405-421 (1969). 2. Chin, J., et al., Am. J. Epidemol., 89., 449-463 (1969). 3. Fulginiti, V.A., et al., Am. J. Epidemol., 89, 435-448 (1969). 4. Prince, G.A., et al., J. Virology, 57, 721-728 (1986). 5. Kim, H., et al., Pediatrics, 52, 56-63 (1973). 6. Hodes, D.S., et al., Proc. Soc. Exp. Biol. Med., 145, 1158-1164 (1974). 7. Belshe, R.B., and Hissom, F.K., J. Med.

Virol., 10, 235-242 (1982). 8. Black, F.L., et al., Am. J. Epidemiol. , 124, 442-452 (1986). 9. Lennon. J.L., and _ Black, F.L., C _ Pediatrics, 108. 671-676 (1986). 10. Pabst, H.F., et al., Pediatr. Infect. Dis. J ^, 11, 525-529 (1992). II. Centers for Disease Control. MMWR, 40, 369-372 (1991). 12. Centers for Disease Control, MMWR, 41: S6, 1-12 (1992). 13. King, G.E .. et al., Pediatr. Infect. Dis. J., 10, 883-887 (1991). 14. Rota, J.S., et al., Virology, 188. 135-142 (1992). 15. Rota, J.S., et al., Virus Res., 31, 317-330 (1994). 16. La b, R.A .. and Kolakosky, D., pages of Volume 1, Fields Virology, B.N. Fields. et al., Eds. (3rd ed., Raven Press, 1996). 17. Sidhu, M.S., et al., Virology, 193, 50-65 (1993). 18. Garcin, D., et al., EMBO J., 14, 6087-6094 (1995). . 19. Radecke, F., et al., EMBO J., 14, 5773-5783 (nineteen ninety five) . 20. Collins, P.L., et al., Proc. Nati Acad. Sci., USA, 92, 11563-11567 (1995). 21. Application of North American Provisional Patent No. 60/047575. 22. European Patent Application No. 702,085. 23. Baron, M.D., and Barrett, T., J. Virology, 71, 1265-1271 (1997). 24. Published International Application No. WO 97/06270. 25. Published International Application No. WO 97/12032. 26. Kato, A., et al., Genes to Cells, 1, 569-579 (1996). 27. Sidhu, M.S., et al., Virology, 208, 800-807 (1995). 28. Shaffer, M.F., et al., J. Immunol., 41, 241-256 (1941). 29. Enders, J.F., et al., N. Enql. J. Med., 263 153-159 (1960). 30. Crowe, J.E., et al., J. Inf. Dis., 173, 829- 839 (1996). 31. Crowe, J.E., et al., Vaccine, 12, 783-790 (1994). . 32. Enders, J.F., and Peebles, M.E., Proc. Soc. Exp. Biol. Med., 8j5, 227-286 (1954). 33. Schwarz, A.J.F., Am. J. Dis. Child , 103, 216-219 (1962). 34. Griffin, D.E., and Bellini, W.J., pages 1267-1312 of Volume 1, Fields Virology, B.N. Fields, et al., Eds. (3rd ed., Raven Press, 1996). 35. Birrer, M.J., et al., Viroloqy, 108, 391-390 (1991): 36. Birrer, M.J., et al., Nature, 293, 67-69. (1981) . 37. Norby, E., et al., Pages 481-507, in The Paramyxoviruses, D. Kingsbury, Ed. (Plenum Press, 1991). 38. Peebles, M.E., pages 427-456, in The Paramyxoviruses, D. Kingsbury, Ed. (Plenum Press, 1991). 39. Egelman, E.H., et al., J. Virol., 63, 2233-2243 (1989). 40. Udem, S.A., et al., J. Virol. Methods, 8, 123-136 (1984). 41. Udem, S.A., and Cook, K.A., J. Virol., 49, 57-65 (1984). 42. Moyer, S.A., and Horikami, S.M., pages 249-274, in The Paramyxoviruses, D. Kingsbury, Ed.

(Plenum Press, 1991). 43. Blumberg, B., et al., Pages 235-247, in The Parainyxoviruses, D. Kingsbury, Ed. (Plenum Press, 1991). 44. Berrett, T., et al., Pages 83-102, in The Paramyxoviruses, D. Kingsbury, Ed. (Plenum Press, 1991). 45. Tordo, N., et al., Sem. in Virolociv, _3, 341-357 (1992). 46. Cattaneo, R., et al., EMBO J., 6, 681-688 (1987). 47. Crowley, J.C., et al., Virology, 164, 498-506 (1988). 48. Banerjee, A.K., and Barik, S., et al., Virology, 188, 417-428 (1992). 49. Castañeda, S.J., and Wong, T.C., J_ Virol. , 63, 2977-2986 (1989). 50. Chan, J., et al., Pages 221-231, in Genetics and Pathogenicity of Negative Stranded Viruses, B.W.J. Mahy and D. Kolakofsky, Eds. (Elsevier Biomedical Press, 1989). 51. Blumberg, B., et al., Cell, 23, 837-845 (1981). 52. Blunberg, B, et al., Cell, 32, 559-567 (1983). 53. Kolakofsky, D., and Blumberg, B.M., pages 203-213, in Virus Persistence, B.M.J. Mahy, et al., Eds. (Cambridge University Press, 1982). 54. Castañeda, S.J., and Wong, T.C., J. Virol. , 64, 222-230 (1990). 55. Curran, J.A., and Kolakofsky, D., Virolocrv, 182, 168-176 (1991). 56. Sidhu, M.S., et al., Virology, 193, 66-72 (1993). 57. Sidhu, M.S., et al., Viroloqy, 202, 631-641 (1994). 58. Baron, M.D., et al., J. Gen. Virol., 77, 3041-3046 (1996). 59. Firestone, C-Y, et al., Viroloav, 225, 419-42 (1996). 60. Bankamp, B., et al., Viroloqy, 216, 272-277 (1996). 61. Sinitsyna, O.A., et al., Res. Virol., 141, 517-531 (1990). 62. Whitehead, S.S., et al., In Press (1998). 63. Anderson, L.J., et al., J. Infect. Dis. , 151, 626-633 (1985). 64. Collins, P.L., pages 103-162 of The Paramyxoviruses, D.W. Kingsbury, Ed. (Plenum Press, NY and London, 1991). 65. Sullender, W.M., J. Virology, 65, 5425-5434 (1991). 66. Lerch, R.A., et al., J. Virology, 64, 5559-5569 (1990). 67. Mallipeddi, S.K., and Samal, S.K., J ^ Gen Virol., 74, 2787-2791 (1993). 68. Johnson, P.R., et al., 3. Virology, 61, 3163-3166 (1987). 69. Stott, E.J., et al., J. Virology, 61, 3855-3861 (1987). 70. Henderson, F.W., et al., N. Engl. J. Med., 300, 530-534 (1979). 71. Hall, S.L., et al., J. Infect. Dis., 163, 693-698 (1991). 72. Mufson, M.A., et al., J. Gen. Virol., 66, 2111-2124 (1985). 73. Glezen, W.P., et al., Am. J. Dis. Child., 140, 543-546 (1986). 74. Hemming, V.G., et al., Clin. Microbiol. Res., 8, 22-33 (1995). 75. Collins, P. L. et. al., pages 1313-1351 of volume 1, Fields Virology, B. N. Fields, et al., Eds. (3rd ed., Raven Press, 1996). 76. Ling, R., and Pringle, C.R., J. Gen. Virol., 70, 1427-1440 (1989). 77. Yu, Q., et al., 3. Virology, 69, 2412-2419 (1995). 78. Mclntosh, K., and Chanock, R.M., pages 1045-1072 of Virology, B.N. Fields, et al., Eds. (2nd ed., Raven Press, 1990). 79. Heminway, B.R. , et al., page 167 of Abstracts of the IX International Congress of Virology, P17-2, (1993). 80. Mink, M.A., et al., Virology, 185, 615-624 (1991). 81. Dickens, L.E., et al., J. Virology., 52, 364-369 (1990). 82. Wagner, R.R., and Rose, J.K., pages 1121- 1135 of volume 1, Fields Virology, B.N. Fields, et al., Eds. (3rd ed., Raven Press, 1996). 83. Barik, S., J. Gen. Virol., 74, 485-490 (1993). 84. Collins, P.L., et al., Pages 259-264 of Vaccines 93: modern approaches to new vaccines including prevention of AIDS, F. Brown et al., Eds. (Cold Spring Harbor Laboratory Press, NY, 1993). 85. Kuo, L., et al., J. Viroloqy., 70, 6892-6901 (1996). 86. Huang, Y.T., and Wertz, G.W., J. Viroloqy, 43, 150-157 (1982). 87. Sambrook, J., et al., Molecular Cloning: A Labonatory Manual, 2a. ed., Cold Spning Harbor Laboratory Press, Cold Spning Harbor, N.Y. (1989). 88. U.S. Patent Application No. 08 / 059,444.

LIST OF SEQUENCES < 110 > American Cyanamid Company < 120 > Mutations Responsible for Mitigation in the Measles Virus or in Subgroup B of the Human Respiratory Syncytial Virus. < 130 > 33428-00 / PCT < 140 > < 141 > < 150 > 60/079466 < 151 > 1998-03-26 < 160 > 59 < 170 > Patentln Ver. 2.0 < 210 > 1 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 1 accaaacaaa gttgggtaag gatagatcaa tcaatgatca tattctagtg cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagactt ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agaccctgag ggattcaaca 600 tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 gaaacaaacc caggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020 aaatggggga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 cgaggatgca gtatcactgc aggcttgttt cagagattgc aatgcatact actgaggaca 1320 agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gtgagaatga ttggggggca gctaccgaga aggaagatag gagggtcaaa cagagtcgag 1440 gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500 aaccggcaca cccatcttcc cccctagaca ttgacactgc atcggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca ctatagtgta acggacaccc caatgacaga aatcttctag 1680 actaggtgcg agaggccgag gaccagaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg 1800 gagccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc acctgcaggg aagagaaggc aggcagt cg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gacctggaga cgcggccagg gagcgatgac gacgctgaaa ctttgggaat ccccccaaga 2100 aatctccagg catcaagcac tgggttacag tgttattatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcrtctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccggacccc 2460 gcacttccga ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tt ggaacgg agatcgcgtc tttattgaca ggtggtgcaa cccaatgtgc tcgaaagtca 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 tacaggagtg gccgcactga tctggtacca gacacccgaa caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgact tgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa 3060 ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ctaaagccga gatgagctca gccgtcgggt ttgttcctga caccggccct 3180 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag ttccacaatg acagagatct caagtcggca acgacttcga cgggacatca 3480 cgctccgata aagggtcgat caacccacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtttc 3600 tgctgggggt tgttgagggc agcgatcccc tagggcctcc aatcgggcga gcatttgggt 3660 ccctgccctt aggtgttggc agatccacag caaagcccga agaactcctc aaagaggcca 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca g ggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggcgataggc ggattgacaa tcatcgacaa cctgggaaga tacagagcaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200 tcacattaga gcaccagtct agatgagcaa agcacaggca gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt aatcgattac 4320 tc ggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500 gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca 4560 agcgcgaaca gccgacggca ccaggcggcc ccagcacaga acagccctga cacaaggcca 4620 ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc 4680 tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc cgggaaagaa acccccagca 4740 attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa 4860 acttagggcc actaaacaaa aaggaacata cacacccaac agaacccaga ccccggccca 4920 cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggttc 4980 ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcaccc aaccatcgac 5040 aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 GAGGAA gccc cacacgacca acccacccca cggcaaccaa accagaaccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca caacccgcgc 5220 accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc gtatcccaca aaggacatca gcctctccaa gtcccccggt 5340 ctcctccttt tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccagacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tgg aggaac aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 aagccatcga ctgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca g acaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagctta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagac 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tccaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 acctaatagc tcacaaggga caattgtgca tcaatccttt gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agacgctgtg 6780 gaattga tacttgcaca cct cggtcctccc atatcattgg agaggttgga cgtagggaca 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 ggagtatgaa cagatattga aggtttatcg agcactagca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc tcttacggga taaagcctga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 cacaagtctc ctcttcgtca tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200 tatctccggc ttccctctgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctgtttg tcatgtctct gagcttgatc gggttgctag ccattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gagctcatga ggctgctgaa atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttaga cttgtattta agtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga 8100 gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgatc ccccttatca cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400 aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 ccattgaagg cgagtgggca ataaca GGAT tccttcatac ggggtcttgt ctgttgatct 8520 gttgagctta gagtctgaca tgcttcggga aaatcaaaat tgatcacaca ttcgggccat 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 aacctcttca ggttagtccc ctgtcccaat taaggaagca ggcgaagact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaggccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag 9120 atagggctgc tagtgaacca atcacatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agccatcctg gagtatgctc g agtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa gtcagtgata 9600 aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacatttga actggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac tattgatgct aggtatacag agcttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ctctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 ggcacggagg cagttggcca tccccctgca ccgctgaccc tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaaca g 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggattg cccccatttt tccagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat 11400 ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag g caaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgctg gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac CTCT cgagtg ataaccagat 12540 tgactatgaa tgtccaatta caattcagag cagggatgg gctattgaca ggaagaaaga 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcgagg tctccaacga tataccacaa caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag ccataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat 13680 cttgggccag tcactatcta tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttctcttgt gtgaaagcga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttat gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc agaggctagg ttatctccag cag gatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 tgatccagga gattgagagt ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaagatcgg atctcaaata tgagcatcaa ggatttcaga cccccacacg 14400 atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cctgctacaa agctgttgag atatcaacát taattaggag atgccttgag ccaggggaag 14580 acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataag gagatactta 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttgcc taacaaagat agctagagga actatagaga atcttatcga attggcagcc 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataag ttatg tagggtctca ttatagagaa gtgaaccttg 15060 tataccctag atacagcaac ttcatatcta ctgaatctta tttggttatg acagatctca 15120 aggctaaccg gctaatgaat cctgaaaaga ttaagcagca tcatctgtga gataattgaa 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tttgggggca cattcttctt tactccggga acagaaagtt gataaataag tttatccaga 15600 atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 ggagaccaaa taacagtcaa gaatggtata agttagtcgg atacagtgcc ctgattaagg 15780 actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt 15894 < 210 > 2 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 2 gttgggtaag accaaacaaa tcaatgatca gatagatcaa tattctagta cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttc 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatcccggga 240 ttaccactcg atctagacct ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatat tt tcacatgatg atccaagtag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca ggattcaaca agaccctgag 600 tgattctggg taccatccta gctcaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga at tagattg gagagaaaat ggttggatgt ggtgaggaar aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 ggaacaaacc caggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatc tg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgc ggt gagttatcca cacttgagtc cttgatgaat ctttaccagc 1020 aactgcacca aaatggggga tacatggtaa tcctggagaa ctcaattcag aacaagttca 1080 gtgcaggatc ataccctc-g ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttacttcga tccagcatat ttcagactag 1200 ggcaagagat ggtgaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 gtatcactgc cgaagatgca aggcttgttt cagagatcgc aatgcatact acagaggaca 1320 ggatcagtag agcggttgga cccagacaat cccaagtgtc attcctacac ggtgatcaaa 1380 gctaccgaga atgaaaatga tgggggggta aggaagatat gagggtcaaa cagagtcggg 1440 gagaagccag agagagctac agagaaacca ggcccagcag agcaagtgac gcgagagcta 1500 aaccgacaca cccatcctcc cccttagaca ttgacactgc atcggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgctcaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca acggacaccc ctagagtgta caatgacaga gatcttctag 1S80 actaggtgca agaggccgag gacca gaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccacca accatccact cccacgattg 1800 gggccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc gcctgcaagg aagagaaggc aagcagtccg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gatctggaga cgcggtcagg gacgctgaaa gagcgatgac cccctcagga ctttgggaat 2100 aatctccagg catcaagcac tgggttacag tgttattatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccaaa agaggcaaca gcttaggaaa actctcaatg ttcccccgcc cccggaccct 2460 gcacttccga ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tttggaacgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 tacaggagtg sccgtactga tctggtacca gacacccgaa caatctcccc gagatcccag 2700 aataatgaag aagggggaga ttattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatcaccaa gctagaatca 2820 tgaaggggga ctgctgttat agttgagtca atcaagaagc agatcaacag gcaaaatatc 2880 ccttggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000 ggcagagatt caggccgagc actggctgaa aacccgttgc gttctcaaga cagccgacaa 3060 atccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ctaaagccga gatgagctca gccgtcgggt ttgttccgga caccggccct 3180 gcatca cgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgacatc aaaggagcca acgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc tagctaatac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag ttccacaatg acagagatct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caacccacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt gaaaagatga ctaggcgaca atgttttatg tacatgtttc 3600 tgctgggggt tgttgaggac agcgatctcc tagggcctcc aatcgggcga gcatttgggt 3660 ctctgccctt aggtgttggc agatccacag caaaacccga agaactcctc aaagaggcca 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcatacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctggatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcagataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggattgacaa ggcgattggc catggg AAGA tgcagagcaa tcatcgacaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa aagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200 tcacattaga gcaccagtct agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccctatgt tacccactga tggatatcaa tgaagacctt aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgttatca ccaaggatta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa gacgaccctc ctcacaatga cagccagaag 4500 gcccggaaaa aaaggccccc tccgaaagac tccacagacc aaatgagagg ccagccagca 4560 agcacgaaca gctgacggca ccagcacaga ccaggcggcc cataaggcca acagccctga 4620 ccaccagcca tcccaatctg catcctcctc gtaggacccc cgaggaccaa cccccaaggt 4680 tgccccccac ccaaaccacc aaccgcatcc ctaccacccc acccccagca cgggaaagaa 4740 actggaagag cccttcccct ttccctcaac acaagaactc cacaaccgaa ccacacaagc 4800 gaccgaggtg acccaaccgc aggcacccga ctccctagac agatcctctc cccctggcaa 4860 actaaacaaa acttagggcc aaggaacata c acacccaac ccccggccca agaacccaga 4920 cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcagg cacaccaacc cccgaacaga cccagcaccc agccatcgac 5040 aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 acccacccca gaggaagccc cgacaaccaa cacacgacca accagaaccc agaccaccct 5160 gggccaccag ttcccagact cggccatcac cccgcagaaa ggaaaggcca caacctgcgc 5220 accccagccc cgatccggcg ggcagccacc caaccctaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc gtatcccaca aaggacatca gcctctccaa gtcccccggt 5340 ctcttcctct tctcgaaggg actaaaagat caatccacca catccgacga cactcaactc 5400 cccgtcccta aaggagacac cgggaatccc ggaattaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccgttt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcag gagtagtcc ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 aagccatcga ctgaactctc caatctgagg gcaagtctgg aaactactaa tcaggcaatt 5940 gaggcaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctcgggc tca aattgctcag atactataca gaaatcctgt cattatttgg ccctagctta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct cggaggagat 6180 atcaataagg tgttagaaaa gctcggatat agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct acccgacgct gtccgagatc aagggggtga ttgtccaccg gc agagggg 6360 gtctcgtaca acataggctc tcaagagtgg tatacgactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatc TGTA ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tccaccaagt cctgtgctcg tacactcgta tctgggtctt ttgggaaccg gttcattttg 6600 acctaatagc tcacaaggga caattgtgca tcaatccttt gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agacgctgtg 6780 tacttgcaca gaattgacct cggtcctccc atatcattgg cgtagggaca agaggttgga 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 cagatattga gg agtatgaa aggtttgtcg agcactagca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc tcttacagga taaagcctga 7080 acatcgaaat cctatgtaag gtcgctctga tcctctacaa ctcttggaac acaaatgtcc 7140 ctcttcgtca cacaagtctc tcaagcaacc accgcatcca gcatcaagcc cacctgaaat 7200 tatctccggc tcccctttgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag ttatcaacag agaacacctt atgattgata gaccttatgt 7380 tttgctggct gttctgttcg tcatgtttct gagcttgatc gggttgctag caattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta ttgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaaccc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 ggctgctgaa gagctcat ga atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttgga cttgtattta agtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtacggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaagggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga 8100 gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt cacgggggag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagctttcag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgacc ccccttctca cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctat cccgacaaca agaacagatg acaagttgcg 8400 aatggagaca tgcttccagc aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ataacaggat tccttcatac ggagtcttgt ctgttgatct 8520 gagtctaaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca 8580 cggttcaggg atggacctat acaagtccaa ccacaacaat gagtattggc tgactatccc 8640 gccaatgaag aacctagccc taggtgtaat caacacattg gagtggatac cgagattcaa 8700 aacctcttca ggttagtccc ctgtcccaat taaggaagca ggcgaagact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgatcct 8820 acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt 8940 gggatcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatagcag 9120 cagtgaacca atagggctgc atcacatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccccg aagttcacct agatagcccg atagttacca 9300 acaagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg agtcca aatgtcatca AGCT taggagttat ccggcccact 9480 ctcatattcc atatccaaac tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg gaaattcgct gtactctaaa gtcagtaata 9600 aggttttcca atgcttgagg gacactaatt cacggcttgg tctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc caatggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 taacatttga gctggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ctgctatgac cattgatgct agatatacag agcttctagg tacatgtgga aagagtcaga 10020 aattgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacggtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcacgag ttagttgaag ctctagatta actgatgaca cattttcata 10260 tacacctgac aggggagatt ttctcatttt tcagaag ttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 cagttggcca ggcacggagg ccgctgaccc tccccctgca tgctgcagac acaatccgga 10500 atgctcaagc ctcaggtgaa ggattaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgcttcatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgacccc cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgata tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctggctg tctcaggagt ccctaaagat ctcaaagaaa 11040 gtcacagagg ggggccagtc ctaaaaacct actcccgaag cccagcccac acaaatacca 11100 ggaacgtgag ggcagcaaaa gggtttatag ggttccctca gataattcgg caggaccaag 11160 acactaatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacaactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggatta ccctcatttt ttcagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat 11400 gcaaagtccc caatgaccaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatttata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcatta gtgcaagggg acaatcagac catagctgta acaaaaaggg 11580 tacccagcac atggccttac aaccttaaga aatgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg acattggcca tcacctcaag gcaaatgaga 11700 caattgtttc atcacatttt tttgtttatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgat g 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcag attctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccaggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcatcactga gaccctccat tgcctgaaga caagtaatga 12180 cacagcaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctaa 12300 tccacagtcc aaacccaatg ttaaagggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc agcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgcta gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat 12540 tgactatgaa tgtccaatta cagggatggt caattcagag ggaagaaaga gctattaaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagcc c taagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 caaggcaaag ggctaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcacatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcaagg tataccacaa tctccaacga caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgctccta gggttgggcg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc caatgataga tcatcccagg atacccagct 13380 ctcgcaagct agagctgagg gcagagctgt gtaccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag ccat AGGAGG caccttgtag 13500 aatttgt ac atggtccaca ccccaactat atcacattct agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gcttatagag ccaagattat 13680 cttgggccag tcactatcta tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcactgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgc atatgaccta cctcgacctg 13980 agagtttaca aagagttaga tttcttttgt gtgaaagtga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttgt gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc ggaggctagg ttatctccag caggatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atcttcggcg aggatcgatc aaacagataa 14280 tgatccagga gattgagagt ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaagatcgg tgagcatcaa atctcaaata ggatttcaga cccccacacg 14400 atgatgttgc aaaattgctc aaagatatca atacaagcaa gcacaatctt cccatttctg 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggaag 14580 acggcttatt cttgggtgag ggatcgggtt ctatgttgat cacttataag gagatactta 14640 aactaaacaa gtgcttctat aatagtgggg tctctgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaggt gctctttaac gggaggcccg aagtcacatg ggtaggcagt gtagattgct 14820 tcaattacat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttacc taacaaagat actatagaga agctagagga attggcagcc atcttatcga 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagttatg tagggtctca ttatagagaa gtgaaccttg 15060 tataccccag atacagcaac ttcatatcta ctgaatctta tttggttatg acagatctca 15120 aggctaaccg gctaatgaat ttaagcagca cctgaaaaga gat aattgaa tcatctgtgc 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaaa ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaggaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctagaatc actcgcaaat 15540 tttgggggca cattcttctt tactccggga acagaaagtt gataaataag tttatccaga 15600 atctcaagtc cggttatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 taacagtcaa ggagaccaag gaatggtata agttagtcgg atacagtgcc ctgattaagg 15780 actaattggt tgaactccgg aaccctaatc ctgccccagg tggttaggca ttatttgtaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc TGGT 15894 < 210 > 3 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 3 gttgggtaag accaaacaaa tcaatgatca gatagatcaa tattctagta cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagacta ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttgtttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag catcaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaagtag tagtgatcaa tccaggtccg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agaccctgag ggattcaaca 600 tgattctggg taccattcta gcccaaattt gggtcttgct cgcgaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga attcagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatc.ct ggatatcaag aggacacccg 840 ggaacaaacc aaggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatccta actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaat ctttaccagc 1020 aaatgggaga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc ataccccctg ctctggagct atgccatggg agtaggggtg gaacttgaaa 1140 actccatggg aggtttgaac tttggtcgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtgaggagg tcagctggga aagtcagttc cacattagca tctgaactcg 1260 gtatcactgc tga ggatgca aggcttgttt cagagattgc aatgcacact actgaggaca 1320 ggaccagtag agcggttgga cccagacaag cccaagtgtc atttctacac ggtgatcaaa 1380 gctaccagga gtgagaatga ttggggggca aggaagatag gagggtcaaa cagagtcggg 1440 gagaagccag ggagagctac agagaaaccg ggtctagcag agcaagcgat gcgagagctg 1500 aaccagcgca cccatcttcc cccctagaca atcggagtca ttgacactgc ggccaagatc 1560 cgcaggacag tcgacggtca gctgacgccc tgctcaggct gcaagccatg gcaggaatct 1620 aggctcagac tggaagaaca acggacaccc ctagggtgta caatgacaga gatcttctag 1680 actaggtgcg agaggccgag gaccagaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagccaacca accatccact cctacgactg 1800 gggccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcac GGCC gtcgaggaag ccatggcagc atg ccacaa 1920 acccaggaca atatcagaca ggaccsaacc acccgcaagg aagaggaggc aggcagttcg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcagtgc acctcgcatc 2040 tgcggtcagg gatctggaga gagcgatgac aacgctgaaa ctttgggaat cccctcaaga 2100 aatctccagg catcaagca c TGGG tacag tgttatcatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctct caggaggaga cgatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatct 2400 acttcccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccgaacccc 2460 gcacttccga ggtagggcca aaaaagggga gacacccatt attagcctca cagacgcgag 2520 tttggagcgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac catcagggcc aggtgcacct gtggggaatg tccccgagtg tgtgagcaat 2640 tacaggagtg gccgcactga gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ttattatgat gatgagctgt tct'ccgatgt ccaagacatc 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaaaaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgc agatgtc gaactcaatc ccgacctgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa 3060 ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcaa 3120 tcgggaaaaa ct'aaagccga gatgagctca gccgtcgggt ttgttcctga caccggcccc 3180 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggc agagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca acgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttac zgc caacctcatg 3360 ccaatcgacc taattagtac agcctaaatc cattataaaa aactta gag caaagtgatt 3420 gcctcccaag ttccacaatg acagagatct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caacctacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgcttracg tacatgtttc 3600 tgctgggggt tgttgaggac agcgatcccc tagggcctcc aatcggg ga gcatttgggt 3660 ccctgccctt aggtgttggt agatccacag caaaacccga agaactcctc aaagaggcca 3720 ctgagcttga catagtcgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctggatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtactac accgttccta 3960 gaagaatgct agaattcaga tcggtcaatg cagtggcttt caacctgctg gtgaccctta 4020 agcgattggc ggattgacaa cctgggaaga tcatcgataa tgcagagcaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgctg 4140 attattgcaa aatgaa AATC gaaaagatgg gcctggtttt tgcact ggt gggatagggg 4200 tcacattaga gcaccagtct agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 gaccttatgt ggttcaaaaa tacccactga tggatatcaa aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcccc 4380 aagaattccg catttacgac gacgtgatca taaatgatga ccaaggacta ttcaaagttc 4440 tgtagaccgt agtgcccagc aatacccgaa aacgaccccc ctcataazga cagccagaag 4500 gcccggacaa aaaagccccc tccaaaagac tccacggacc aagtgagagg ccagccagca 4560 agcgtgaaca gctgacggca ccaggcggcc tgggcacaga acagcc ga cacaaggcaa 4620 ccaccagcca tcccaatctg cgtcctcctc gtgggacccc cgagga aa cccccaaggt 4680 cgcccccgac ccagaccacc aaccgcatcc ccacagcccc cgggaaagag acccccagca 4740 actggaaggc ccctccccct ttccctcaac gcaagaactc cacaaccgaa ccgcacaagc 4800 gatcgaggtg acccaaccgc aggcatccga ctccctagac agatcc ctc cccccggcaa 4860 actaaacaaa acttagggcc aaggaacata cacacccgac agaacc aga ccccggccca 4920 cggcgccgcg cccccacctc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcagg cacaccaacc ctc gaacaga cccagcaccc agccatcgac 5040 aattcaagac ggggggcccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 acccacccca gaggaagccc cacacgacca caggaaccga accagaatcc agaccaccct 5160 gggccaccag ttcccagact cggccatcac ggaaaggcca cccgcagaaa caacccgcgc 5220 acccctgccc tgatccggtg ggcggccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaagggccc aaagacatca gtatcccaca gcctct caa gtcccccggt 5340 ctccccctct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaattc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtagggat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgctg gagttgtcct ggcgggtgcg 5820 gccctaggcg ttgccacagc tgctcagata acagccggc to ttgcacttca ccagtccatg 5880 aagccatcga ttgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctagggctca aattgctcag atactataca gaaatcctgt cactatttgg ccccagctta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagat 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtactc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagaaggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tccaccaagt cctgtgctcg tacacttgta tccgggtctt ttgggaaccg gttcatttta 6600 tcacaaggga atctaatagc gcaagtgtta tcaatccttt caattgtgca cacaacagga 6660 acgatcatta atcaggaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtggtcgagg tgaacggcgt gaccatccaa gtcgggagca ggcggtatcc ggacgctgtg 6780 tacttgcaca gaattgacct cggtcctccc atatcattgg cgtagggaca agaggttgga 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 ggagtatgaa cagatattga aggtttatcg agcactagca cctgattgca tagtttacat 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaa AAGG gagaacaagt tggtatgtca agaccaggcc tcttacagga taaagcctga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 ctcttcgtca cacaagtctc tcaagcaacc accgcatcca gcatcgagcc cacctgaaat 7200 tgtctccgga ttccctctgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag acaaccccca 7320 tcctagggga agtaggatag ttattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctattcg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cataagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 gatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcaccgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gaactcatga ggctgctgaa atgcattggt gaactcaact ctactggagg ccagggtaac 7800 ctagctgtct caatcagttc caaagggaaa ctgctcaggg tcagaggtca cccactacaa 7860 attctcaaac to tgtcgctgt ccctgttgga cttgtattta aatcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtacggggga acttacctag tggaaaagcc 7980 taatctgagc agtaaagggt cagagttgtc acaactgagc atgcaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga 8100 gcaaccagtc agtaatgatt tcagcaactg catggtggct ttgggggagc tcaaattcgc 8160 agccctttgt cacagggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 ccccctatca acggatgatc cagtgataga caggctctac ctctcatctc acagaggcgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cggacagatg acaagttgcg 8400 aatggagaca tgcttccagc aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttaatct 8520 gttgagctta gagtctgaca tgcttcagga aaatcaaaat tgatcacaca ttcgggccat 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttagtccc tacctct tca ctgttccaat taaggaagca ggcgaggact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacctatgat acttccagag ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataagg tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggatata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcactcgg gaagatggaa ccaaccgcag 9120 atagggctgc cagtgaacca atcacatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agctatcctg gagtatgctc gagtccctca cgcatacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccgacccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 caaggaagat ccgtgagctc ctcaaaaagg gaaattcgct gtactccaaa gtcagtgata 9600 aggttttcca atgcctgagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaaatt attaacttgg gagtttacat gcacagctcc caatggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac cagtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacgcttga actggtcttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac cattgatgct aggtatacag agcttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttaccaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ccctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatattct gtggaatcat aatcaacggc tatcgtgaca 10440 cagttggcca ggcacggagg cccctgaccc tccccctgca tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaaaggaa ctgggtcacg gaggcttgta aatgttttcc 10740 ttaatgattc gagctttgac ccatatgaca tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aattatttta aggacaatgg gatggccaag gacgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaaccc actcccgaag cccagtccac acaagtacca 11100 agaacgtgag agcagcaaaa gggtttatag gattccctca tgtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaggctt acgagacagt cagtgcattt atcacgactg 11220 gt atctcaagaa actgcctt aattggagat atgagaccat cagcttattt gcacaaaggc 11280 taaatgagat ttacggatta ccctcatttt tccagtggct gcataagagg cttgaaacct 11340 ctgtcctcta tgtaagtgac cctcattgcc cccctgacct tgacgcccat gtcccgttat 11400 gcaaagtccc caatgaccaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatttata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccttac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg acataggcca tcacctcaag gcaaatgaga 11700 caattgtctc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa atcctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgatct cttaataagg atggcactgt tgcccgctcc tatcgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc tcatcactaa tgcctgaaga gacccttcat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgcgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaagggt tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgcta gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat 12540 tgactatgaa tgtccaatta caatttagag cagggatggt ggaagaaaga gctattgaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggctagagcc ctaagaagcc 12660 atatgtgggc aaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gccatgagac atgtgtcatc tgcgagtgt g 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttat ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 caaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtaccactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcaagg tataccacaa tctccaacga caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaggg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagcttagg gcagagctat staccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag ccataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt t cagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gcttatagag ccaagattat 13680 tcactatcta cttgggccag tgtgcagcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcttc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttacaca tgatgctcaa 13920 caactgtgtg caacatgatt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttcttctgt gtgaaagcga cgaggatgta gtaccggaca 14040 tatccaggca gattcgacaa aaacacttgt gtgttctagc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctacgac ctgtagagaa atgtgcagtt ctaaccgatc 14160 atatcaaggc agaggctagg ttatctccag cagggtcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 tgatccagga gattgagagt ttcatttttg acgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaagatcgg atctcaaata tgagcatcaa ggatttcaga cctccacacg 14400 atgatgttgc aaaattgctc aaagatatca acacaagcaa GCAC aatctt cccatttcag 14460 ggggtaatct cgccaattat gaaatccacg ctttccgcag aatcgggtta aactcatccg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggaag 14580 acggcttgtt cttgggtgag gggtcgggtt ctatgttgat cacttataag gagatactaa 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggtc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agtcagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttacc taacaaagat actatagaga agctagagga attagcagcc atcttatcga 14940 tggctctgct ccttggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagttatg tagggtctta ttatagagaa gtgaaccttg 15060 tctaccctag atacagcaac ttcatatcta ctgaatctta tttagtcatg acagatctca 15120 aagctaaccg gctaatgaat cctgaaaaga ttaagcagca gataattgaa tcatctgtgc 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg gtatcaaccc tattctgaag aaacttacac 15300 ctatagagca ggtgctgatc aat gcgggt tggcaattaa cggacctaaa ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaactct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccatg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tttgggggca tattcttctt tactccggga acagaaagtt gataaatcgg tttatccaga 15600 atctcaagtc cggttacctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ctaagtcaga gaaacagatt attatgacgg ggggtttaaa acgtgagtgg gtttttaagg 15720 taacaatcaa ggagaccaaa gaatggtata agttagtcgg atacagtgcc ctgattaagg 15780 attaattggt tggactccgg gaccctaatc ctgccctagg tagttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt 15894 < 210 > 4 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 4 gtcgggcaag accaaacaaa tcaatgatca gatagatcaa tattctagta cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 tgaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaacc aaacacatta ttatagtacc gattcctcaa aattcctgga 240 ttaccactcg atccagacta ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag catcaggctg ttagaggttg 420 ttcagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaagcag tagtgatcaa tccaggtccg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agatcctgag ggattcaaca 600 tgattctggg taccattcta gcccagatct gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc tttacgccga ttcatggtgg ctctaatcct ggatatcaag aggacacccg 840 ggaacaaacc taggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcttg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaat ctttaccagc 1020 aaatgggaga aactgcaccc tcctagagaa tacatggtaa aacaagttca ctcaattcag 1080 gcgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggtcgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtgaggagg tcagctggaa aggtcagttc cacattggca tccgaactcg 1260 cgaggatgca gtatcactgc aggcttgttt cagagattgc aatgcatact actgaggaca 1320 ggatcagtag agcggtcgga cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gtgagaatga ttggggggca gctaccagga aggaagacag gagggtcaaa cagagtcggg 1440 gagaagccag ggagagctac agagaaaccg agtccagcag agcaagtgat gcgagagctg 1500 cccatcctcc aaccagcatg cccctagaca ttgacactgc atcggagtca ggccaagatc 1560 cgcaggacag tcgaaggtca gctgacgctc tgctcaggct gcaagccatg gcaggaatct 1620 aggctcagac tggaagaaca ctagggtata acggacaccc caatgacaga gatcttctag 1680 attaggtgcg agaggccgag gaccagaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagccaacca accatccact cccacgactg 1800 gagccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc gtcgaggaag ccatggcagc atggtcagaa 1920 atccaggaca atatcagaca ggaccgagcc gcctgcaagg aagaggaggc aggcagttcg 1980 ggtctcagca aaccatgctt ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gatctggaga cgcggtcagg aagcgatgac gacgctgaaa ctttgggaat cccctcaaga 2100 aatctccagg catcaagcac tgggttacag tgttatcatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcacc CTCT caggaggaga cgatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggsgttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcccgaa actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccgaacccc 2460 gcacttccga agtagggcca aaaaagggga gacacccatt attggcctca cagacgcgag 2520 tttggaacgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac cgtcagggcc agatgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 gccgcactga tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctccgatgt ccaagacatc 2760 aaaacagcct tggccaaaat acacgaggat taatctccaa aatcagaaga gctagaatca 2820 ttgctgttat tgaagggaga agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca agcatcatga acacctctca ttgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaactcaatc ccgacctgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa agcccgttgc gttctcaaga cagccgacaa 3060 ctccagggaa t gactaatgg acggaccagt tccagaggac agctgctgaa ggaatttcaa 3120 tcgggaaaaa ctaaagccga ggtgagctca gccgtcgggt ttgtccctga caccggccct 3180 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga gga cggaag 3240 cgttacctgt tgactctcct tgatgatatc aaaggagcca acgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc taattagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcctaag ttccacaatg acagagatct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caacctacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggtgata ggaaggatga atgctttatg tacatgtttc 3600 tgctgggggt tgttgaggac agagatcccc tagggcctcc aatcgggcga gcattcgggt 3660 ccctgccctt aggtgttggt agatccacag caaaacccga aaagaggcca ggaactcctc 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa gtgttctaca tgaaaaactg 3780 acaacacccc actaaccctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaatgcaaa ccaagtgtgc aatgcggtta atctaatacc gctggacacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccca 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt gtgaccctca caacctgcta 4020 ggcgattggc ggattgacaa cctgggaaga tcatcgacaa tgcagagcaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaag atgg gcctggtttt tgcacttggt gggatagggg 4200 gcaccagtct tcacattaga agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccactga tggatatcaa tgaagacctt aatcggttac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatacccgaa aacgaccccc ctcataatga cagccagaag 4500 gcccggacaa aaaagccccc tccaaaagac ttcacggacc aagcgagagg ccagccagca 4560 agtgtggaca gccgacagca caagcacaga ccaggcggcc cacaaggcca acagccccga 4620 ccaccagcca tcccaatccg cgtcctcctc gtaggacccc cgaggaccaa cccccaaggt 4680 cgctccggac acagaccacc agccgcatcc ccacagccct acccccagca cgggaaagga 4740 actggaaggc cccttccccc ctcccccaac gcaagaaccc cacaaccgaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac "agaccctccc tccccggcat 4860 actaaacaaa acttagggcc aaggaacaca cacacccgac agaacccaga ccccggcccg 4920 cggcaccgcg cccccacccc ccgaaaacca gagggagccc ccaaccaatc ccgccgcccc 4980 ccccggtgcc cacaggtagg cacaccaacc cccgaacaga cccagcaccc agccaccgac 5040 aatccaagac ggggggcccc ccccaaaaaa aggcccccag gggccgacag ccagcatcgc 5100 gagga agccc cacacgacca acccacccca cggcaaccaa accagagccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac cccgaaaaaa ggaaaggcca caacccgcgc 5220 accccaggcc cgatccggcg ggaagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccaaaccgca tgggggaccc aaagacatca gtatcccacc gcctctccaa gtcccccggt 5340 ctcctcctct tctcgaaggg accaaaagat caatccacca catccgacga cactcaattc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaatgtctt tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtagggat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattgg tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gaaattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agacgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagttgtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 akgccatcga ctgaactctc caatctgaga gcaagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca ggcaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctagggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagctta 6120 tatctgcgga cgggacccca gatatccatc caggctttga gctatgcgct tgggggagat 6180 atcaataagg tattagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca atataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tccaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 acctaatagc tcacaaggga caattgtgca tcaatcctct gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtggtcgagg tgaacggtgt gaccatccaa gtcgggagca ggaggtatcc ggacgcggtg 6780 tacctgcaca gaattg acct cggtcctccc atatcattgg agaagttgga cgtagggaca 6840 aatctgggga atgcaattgc taagctggag gatgccaagg aattgctgga gtcatcggac 6900 ggagtatgaa cagatattga agcactagca aggtttatcg cctgattgca tagtttacat 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gggaacaagt tggtatgtca agaccaggcc taaagcctga tcttacaggg 7080 acatcaaaat cctatgtaag gtcgctctga tcccctacaa ctcttgaaac acagatttcc 7140 cacaagtctc ctctccgtca tcaagcaacc accgcatcca gcatcaaggc cacccgaaat 7200 tgtctccggc ttccctctgg ccgaacgata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac accgagaccg aataaatgcc ttctacaaag acaaccccca 7320 tcctaaggga agtaggatag ttattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctattcg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cattagactc catcgggcag ccatctacac cgcagagatc cataagagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 gatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aaaattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gaactcatga ggctgctgaa atgcattggt gaactcaact ctactggagg ccagggcaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttgga cttgtattta agtcgaggtt acaatgtgtc 7920 atctatagtc accatgacat cccagggaat gtacggggga acttacctag tgggaaagcc 7980 taatctgagc agtaaagggt cagagttgtc acaactgagc atgcaccgag tgtttgaagt 8040 aggggttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actattttga 810.0 gcaaccagtc agtaatgatt tcagcaactg catggtggct ttgggggagc tcaggttcgc 8160 agccctctgt cacagggaag attctgtcac ggttccctat caggggtcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgatc ccccctatca cagtgataga taggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cggacagatg acaagttgcg 8400 aatggagaca tgcttccagc aggcgtgtaa gggtaaaaac caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ATAAC aggat tccttcatac ggggtcttgt ctgttaatct 8520 gttgagctta gagtctgaca tgcttcagga aaatcaaaat tgatcacaca ttcgggccat 8580 cggttcaggg atggacctat acaaaaccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttag-ccc aacctcttca ctgttccaat caaggaagca ggcgaggact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtaattct 8820 acctggtcag gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tatgtttaca gcccaggccg ctcattttct tacttttatc cttttaggtt 8940 gcctataaag ggggtcccaa tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ttcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcactcgg gaagatggaa ccaatcgcag 9120 atagggctgc cagtgaaccg atcacatgat gtcactcaga caccaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggtttccc gtcatggact 9240 cgctatctgt caaccagatc ttgtaccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agctatcctg gagtatgctc gagtccctca cgcttacagc cttgaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attctccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 caaggaagat ccgtgagctc ctaaaaaagg gaaattcgct gtactccaaa gtcagtgata 9600 aggttttcca atgcctgagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaaatt attaacttgg gagtttacat gcacagctcc caatggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagc 9840 tgttaatctc tcgtgacctt gttgctataa tcagtaagga gtctcaacat gtatattacc 9900 tgacgtttga actggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac cattgatgct aggtatgcag aacttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagctatgc 10080 tggagccact ttcacttgct tacctgcaac tgagggacat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ccttagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gtcaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaagggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 ggcacggagg cagttggcca tccccctgca cccctgaccc tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggagatcat 10560 ttgctggagt gagatttggc tgttttatgc ctcttagcct ggacagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgatcct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgata tgataatgta tgtcgtaagt ggagcctacc 10800 tccatgaccc tgagttcaat ctgtcttaca gcctgaaaga aaaggagatc aaggaaaca g 10860 gtagactttt cgctaaaatg acttacaaaa tgagggcatg ccaagtgatc gctgaaaatc 10920 taatctcaaa cgggattggc aagtatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctggctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 agcagaaaaa ggaacgttaa gggtttgtag gattccctca tgtaattcgg cagaatcaag 11160 acactgatca tccggagaat atagaaacct acgagacagt cagcgcattt atcacgactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttat t gcacagaggc 11280 taaatgagat ttacggatta ccctcatttt ttcagtggct gcataagagg cttgaaacct 11340 ctgtcctcta tgtaagtgat cctcattgcc cccccgacct tgacgcccat gtcccgttat 11400 caatgaccaa gcaaagtccc atcttcatca agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctacttata cctggcrgct tatgagagcg 11520 gggtaaggat tgcctcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccttac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg acattggcca tcacctcaag g caaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc attgcaagat gtgtattctg gtcagagact atagttgatg 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta tcttgcatat tccctgaacg tcctaaaagt gatacagcaa attttgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgagatgt agtcataccc ctcctcacaa 12000 acaacgatct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaacatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcatcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgcgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctaa 12300 tccatagtcc aaacccaatg ttaaaagggt tattccatga tgacagtaaa gaagaggacg 12360 agagactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgcta gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac CTCT cgagtg ataaccagat 12540 tgactatgaa tgtccaatta cagggatggt caatttagag ggaagaaaga gctattgaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggctagagcc ctaagaagcc 12660 atatgtgggc aagactagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc ttggttctac gtcccatata agaacagaca cactgatgag 12900 tgaagcttgc gccccaagta cttcgtaaga gatccttgcg atctgccgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 caaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcgactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtcag agtggcaagg tctccaacga tataccacaa caatctctca tttgtcatat 13200 cagataagaa agttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag atactggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag ccataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacattct agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gcttatagag ccaagattat 13680 cttgggccag tcaccatcta tgtgcagcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcttc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta ccttgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttcttttgt gtgaaagcga tgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttgt gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accgattcga ggtctaaggc cggtagagaa atgtgcagtt ctaaccgatc 14160 atatcaaggc agaggctagg ttatctccag cag gatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccgtcg aggatctatc aaacagataa 14280 tgatccagga gattgagagt ttcatttttg atgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaaggtcgg atctcaaata tgagcatcaa ggatttcaga cctccacacg 14400 atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag 14460 ggggtagtct tgccaattat gaaatccatg ctttccgcag aatcgggtta aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggaag 14580 acggcttgtt cttgggtgag gggtcgggtt ctatgttgat cacttataag gagatactaa 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaggt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt atagattgct 14820 tcaatttcat agtcagtaat atccctacct ctagtgtggg atttatccat tcagatatag 14880 agaccttacc caacaaagat agttagagga actatagaga atcttatcga attggcagcc 14940 tggctctact ccttggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagc TATG tagggtctca ttatagagaa gtgaaccttg 15060 tctaccctag gtacagcaac ttcatatcta ctgaatctta tttagttatg acagatctca 15120 aagctaaccg gctaatgaat cctgaaaaga ttaagcagca gataattgaa tcatctgtgc 15180 ggacttcacc tggacttata ggtcacatcc tatctatcaa gcaactaagc tgcatacaag 15240 caattgtggg aggcgcagtt agtagaggtg atatcaaccc tattctgaaa aaacttacac 15300 ctatagagca ggtgctgatc agttgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattaatcca ccatgatgtt gcctcagggc aagatggatt gcttaactct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agtaggcaac gagaacttgt atctaggatc actcgcaaat 15540 tttgggggca tattcttctt tactccggga acagaaagtt gataaatcgg tttatccaga 15600 atctcaagtc cggttatcta atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttaaa acgtgagtgg gtttttaagg 15720 ggagaccaaa taacagtcaa gaatggtata agttagtcgg atacagcgct ctgattaagg 15780 attaattggt tgaactccgg aaccctaatc ctaccctagg tagttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt 15894 < 210 > 5 < 211 > 15894 < 212 > DNA < 213 > Measles Yirus - < 400 > 5 accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagactt ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agaccctgag ggattcaaca 600 tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tggttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 gaaacaaacc caggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020 aaatggggga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 cgaggatgca gtatcactgc aggcttgttt cagagattgc aatgcatact actgaggaca 1320 agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gctaccgaga gtgagaatga ttggggggca aggaagatag gagggtcaaa cagagtcgag 1440 gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500 aaccggcaca cccatcttcc cccctagaca ttgacactgc aacggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca ctatagtgta acggacaccc caatgacaga aatcttctag 1680 actaggtgcg agaggccgag ggcca gaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg 1800 gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gacctggaga cgcggtcagg gacgctgaaa gagcgatgac ccccccaaga ctttgggaat 2100 aatctccagg catcaagcac tgggttacag tgttattacg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccggacccc 2460 gcacttccgg ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tttggaacgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 tacaggagtg gccgcactga gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa aacccgttgc gttctcaaga cagccgacaa 3060 ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ctaaagccga gatgagctca gccgtcgggt ttgttcctga caccggccct 3180 gcatca cgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag ttccacaatg acagagacct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caacccacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtttc 3600 tgctgggggt tgttgaggac agcgattccc tagggcctcc aatcgggcga gcatttgggt 3660 ccctgccctt aggtgttggc agatccacag caaagcccga aaagaggcca aaaactcctc 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggattgacaa ggcgataggc cctggg AAGA tacagagcaa tcatcgacaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200 tcacattaga gcaccagtct agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500 gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca 4560 agcgcgaaca gccgacggca ccagcacaga ccaggcggcc cacaaggcca acagccccga 4620 ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc 4680 tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc acccccagca cgggaaagaa 4740 attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa 4860 actaaacaaa acttagggcc aaggaacata c acacccaac ccccggccca agaacccaga 4920 cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcaccc aaccatcgac 5040 aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 acccacccca gaggaagccc cggcaaccaa cacacgacca accagaaccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca caacccgcgc 5220 accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc gtatcccaca aaggacacca gcctctccaa gtcccccggt 5340 ctcctcctct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc 5400 cccaccccta aaggagacac cgggaátccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag áatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 aagccatcga ctgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctcg ggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagttta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagac 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcggaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tacaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 acctaatagc tcacaaggga caattgtgca tcaatccttt gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtagtcgagg tgaacggcgt gatcatccaa gtcgggagca ggaggtatcc agacgctgtg 6780 tacttgcaca gaattgacct cggtcctccc atatcattgg cgtagggaca agaggttgga 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 cagatattga ggagtatgaa aggtttatcg agcactagca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc taaagcctga tcttacggga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 ctcttcgtca cacaagtctc tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200 tatctccggc ttccctctgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 ggctgctgaa GAGCT catga atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga 8100 gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgatc ccccttatca cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400 aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct 8520 gagtctgaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttagtccc tacctcttca ctgtcccaat taaggaagca ggcgaagact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag 9120 atagggctgc tagtgaacca atcacatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtc atca agtccaagct taggagttat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa gtcagtgata 9500 aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacatttga actggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac tattgatgct aggtatacag agcttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ctctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcat ttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 cagttggcca ggcacggagg ccgctgaccc tccccctgca tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgt at 11400 ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag gcaaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgat g 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tcctggatca 'tagtgtcaca ggggcaagag agtctattgc aggcatgctg gataccacaa 12480 aaggcttgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat 12540 tgtccaatta tgactatgaa caattcagag cagggatggt gctattgaca ggaagaaagc 12600 gaaatgtcct ca'ttgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttatt? GGC gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcgagg tataccacaa tctccaacga caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag cc ataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat 13680 cttgggccag tcactatcta tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttctcttgt gtgaaagcga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttat gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc agaggctatg ttatctccag caggatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 gattgagagt tgatccagga ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 cgg caaaga atctcaaata cagcaacaac ggctttcaga tgagcatcaa cccccacacg 14400 atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggagg 14580 acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataag gagatactta 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca cagaatggga gtaggtaata 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttgcc tgacaaagat agctagagga actatagaga atcttatcga attggcagcc 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagttatg tagggtctca ttatagagaa gtgaaccttg 15060 tataccctag atacagcaac ttcatctcta ctgaatctta tttggttatg acagatctca aggctaaccg gctaatgaat 15120 tta cctgaaaaga agcagca tcatctgtga gataattgaa 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tctgggggca cattcttctt tactccggga acagaaagtt gataaataag tttatccaga 15600 atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 ggagaccaaa taacagtcaa gaatggtata agttagtcgg atacagtgcc ctgattaagg 15780 actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc TGGT 15894 < 210 > 6 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 6 accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagactt ctggaccggt tggtgaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga ccag-cacaa tctggcctta ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcgg ttgaagtgca atctcagata ggattcaaca agaccctgag 600 tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 gaaacaaacc caggattgct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020 aaatggggga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 gtatcactgc cgag gatgca aggcttgttt cagagattgc aatgcatact actgaggaca 1320 agatcagtag agcgg-TGGA cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gctaccgaga gtgagaatga ttggggggca aggaagatag gagggtcaaa cagagtcgag 1440 gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500 aaccggcaca cccatcttcc cccctagaca ttgacactgc aacggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca ctatagtgta acggacaccc caatgacaga aatcttctag 1680 actaggtgcg agaggccgag ggccagaaca acatccgcct accatccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg 1800 gagccaatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 cgcggtcagg gácctggaga gagcgatgac gacgctgaaa ctttgggaat ccccccaaga 2100 aatctccagg catcaagca c tgggttacag tgttattacg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctct caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccggacccc 2460 gcacttccgg ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tttggaacgg agatcgcgtc tttattgaca cccaatgtgc ggtggtgcaa tcgaaagtca 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 tacaggagtg gccgcactga gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 acgaccccac aaggatccca TGCA gatgtc ccgacttgaa gaaatcaatc acccatcata 3000 ggcagagatt caggccgagc actggccgaa gttctcaaga aacccgttgc cagccgacaa 3060 ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ct'aaagccga gatgagctca gccgtcgggt ttgttcctga caccggccct 3180 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag gtccacaatg acagagacct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caacccacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtttc 3600 tgctgggggt tgttgaggac agcgattccc tagggcctcc aatcgggcga gcatttgggt 3660 tcctgccctt aggtgttggc agatccacag caaagcccga aaagaggcca aaaactcctc 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggcgataggc ggattgacaa tcatcgacaa cctgggaaga tacagagcaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 aatgaa attattgcaa AATC gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200 tcacattaga gcaccagtct agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500 gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca 4560 agcgcgaaca gccgacggca ccaggcggcc acagccctga ccagcacaga cacaaggcca 4620 ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc 4680 tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc cgggaaagaa acccccagca 4740 attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccsaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa 4860 acttagggcc actaaacaaa aaggaacata cacacccaac ccccggtcca agaacccaga 4920 cggtgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcasg g acaccaacc cccgaacaga cccagcaccc aaccatcgac 5040 aatccaagac gggggggCCC ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 acccacccca gaggaagccc cacacgacca cggcaaccaa accagaaccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac ggaaaggcca cccgcagaaa caacccgcgc 5220 accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc aaggacatca gtatcccaca gcctctccaa gtcccccggt 5340 ctcctcctct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcag ata acagccggca ttgcacttca ccagtccatg 5880 aagccatcga ctgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gagacaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagttta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagac 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcggaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tacaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 tcacaaggga acctaatagc caattgtgca gcaagtgtta tcaatccttt cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agacgctgtg 6780 tacttgcaca gaattgacct cggtcctccc atatcattgg cgtagggaca agaggttgga 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 ggagtatgaa cagatattga aggtttatcg agcactagca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaa AAGG gagaacaagt tggtatgtca agaccaggcc tcttacggga taaagcctga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 ctcttcgtca cacaagtctc tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200 tatctccggc ttccctctgg ccgaacaata tcggtagtta atcaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 aatctctgac aagattaaat tccttaatcc gg agggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gagctcatga ggctgctgaa atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc caaagggaaa ctgctcaggg tcagaggtca cccactacaa 7860 attctcaaac at gtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga 8100 gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 ccccttatca acggatgatc cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400 aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct 8520 gttgagctta gagtctgaca tgcttcggga aaatcaaaat tgatcacaca ttcgggccat 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttagtccc tacctctt ca 8760 ctgtcccaat taaggaagca ggcgaagact gccatgcccc aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag 9120 atagggctgc tagtgaacca atcacatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggagttat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtcagtgata gtactccaaa 9600 aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacatttga actggttttg atgtattgtg atgtcataga ggggaggtta atgacagaga 9960 ccgctatgac tattgatgct aggtatacag agcttctagg aagagtcaga tacatgtgga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaactgaag ctctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 cagttggcca ggcacggagg ccgctgaccc tccccctgca tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg 11220 gtactgcctt atctcaagaa aa ttggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat 11400 ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag gcaaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgctg gataccacaa 12480 aaggcttgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat 12540 tgactatgaa tgtccaatta cagggatggt caattcagag ggaagaaaga gctattgaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgt g 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcgagg tataccacaa tctccaacga caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga .aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagatgca ctttaattga acaaggctat acacccagag ccataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat 13680 tcactatcta cttgggccag tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttctcttgt gtgaaagcga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttat gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc agaggctatg ttatctccag caggatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 tgatccagga gattgagagt ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaagatcgg atctcaaata tgagcatcaa ggctttcaga cccccacacg 14400 atgatgttgc aaaattgctc aaagatatca gca acacaagcaa caatctt cccatttcag 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggagg 14580 acggcttgtt cttgggtgag ggatcgggtt ctatgttgat gagatactta cacttataaa 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttgcc tgacaaagat actatagaga agctagagga attggcagcc atcttatcga 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagttatg tagggtctca ttatagagaa gtgaaccttg 15060 tataccctag atacagcaac ttcatctcta ctgaatctta tttggttatg acagatctca 15120 aggctaaccg gctaatgaat cctgaaaaga ttaagcagca tcatctgtga gataattgaa 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tctgggggca cattcttctt tactccggga acaaaaagtt gataaataag tttatccaga 15600 atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 taacagtcaa ggagaccaaa gaatggtata agttag cgg atacagtgcc ctgattaagg 15780 actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt 15894 < 210 > 7 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 7 accaaacaaa gttgggtaag gatagttcaa tcaatgatca ttttctagtg cacttaggat 60 tcaagatcct attatcasgg acaagagcag gattaaggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagactt ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga ccaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agaccctgag ggattcaaca 600 tgattctggg taccatccta gctcaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 gaaacaaacc caggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020 aaatggggga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc ataccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 cgaggatgca gtatcactgc aggcttgttt cagagattgc aatgcatact actgaggaca 1320 agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gtgagaatga ttggggggca gctaccgaga aggaagatag gagggtcaaa cagagtcgag 1440 gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500 aaccggcaca cccatcttcc cccctagaca ttgacactgc atcggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca ctatagtgta acggacaccc caatgacaga aatcttctag 1680 actaggtgcg agaggccgag ggccagaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg 1800 gagccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gacctggaga cgcggtcagg gagcgatgac gacgctgaaa ctttgggaat ccccccaaga 2100 aatctccagg catcaagcac tgggttacag tgttattatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcacc CTCT caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc tccggacccc 2460 gcacttccgg ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tttggaacgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagtg tgtgagcaat 2640 gccgcactga tacaggagtg gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat taatctccaa aatcagaaga gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa aacccgttgc gttctcaaga cagccgacaa 3060 ctccaaggaa t gacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ctaaagccga gatgagctca gccgtcgggt ttgttcctga caccggccct 3180 gcatcacgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag ttccacaatg acagagatct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggttgat caacccacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtttc 3600 tgctgggggt tgttgaggac agcgatcccc tagggcctcc aatcgggcga gcatttgggt 3660 ccctgccctt aggtgttggc aaatccacag caaagcccga aaagaggcca aaaactcctc 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa gtgttctaca tgaaaaactg 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc agtgcggtta atctgatacc gctcgatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggcgataggc ggattgacaa tcatcgacaa cctgggaaga tacagagcaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaag atgg gcctggtttt tgcacttggt gggatagggg 4200 gcaccagtct tcacattaga agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccgctga tagatatcaa tgaagacctt aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500 gcccggacaa aaaagccccc tccgaaagac tccacggacc aagcgagagg ccagccagca 4560 agcgcgaaca gccgacggca ccagcacaga ccaggcggcc tacaaggcca acagccctga 4620 ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc 4680 tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc cgggaaagaa acccccagca 4740 attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa 4860 acttagggcc actaaacaaa aaggaacata cacacccaac agaacccaga ccccggccca 4920 cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcaccc aaccatcgac 5040 aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 GAGGAA gccc cacacgacca acccacccca cggcaaccaa accagaaccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca caacccgcgc 5220 accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc gtatcccaca aaggacatca gcctctccaa gtcccccggt 5340 ctcctcccct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 aagccatcga ctgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca g acaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 ctcgggctca aattgctcag atactataca gaaatcctgt cattatttgg ccccagctta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagac 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tccaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 acctaatagc tcacaaggga caattgtgca tcaatccttt gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga tcactgcccg 6720 gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agatgctgtg 6780 gaattga tacttgcaca cct cggtcctccc atatcattgg agaggttgga cgtagggaca 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 ggagtatgaa cagatattga aggtttatcg agcactagca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc tcttacggga taaagcctga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 cacaagtctc ctcttcgtca tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200 tatctccggc ttccctctgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gagctcatga ggctgctgaa atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga 8100 gcaaccagcc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt cacggggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgatc ccccttatca cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400 aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 ccattgaagg cgagtgggca ataaca GGAT tccttcatac ggggtcttgt ctgttgatct 8520 gttgagctta gagtctgaca tgcttcggga aaatcaaaat tgatcacaca ttcgggccat 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 gccaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttagtccc tacctcttca atgtcccaat taaggaagca ggcgaagact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacctacgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaggccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag 9120 atagggctgc tagtgaacca atctcatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agccatcctg gagtatgctc g agtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgtcatca agtccaagct taggag tat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa gtcagtgata 9600 aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacatttga actggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac tattgatgct aggtatacag agcttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ctctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctcatttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 ggcacggagg cagttggcca tccccctgca ccgctgaccc tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaaca g 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat 11400 ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag g caaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgatg 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaascatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct 11940 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgctg gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac CTCT cgagtg ataaccagat 12540 tgactatgaa tgtccaatta cagggatggt caattcagag ggaagaaaga gctattgaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc ttggttctac gtcccatata agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgátg atagctcttg gaacgaagcc tggttgttgg 13020 ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcgagg tctccaacga tataccacaa caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagataca ctttaattga acaaggctat acacccagag ccataggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat 13680 cttgggccag tcactatcta tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttctcttgt gtgaaagcga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttat gtgttctggc agatttgtac tgtcaaccag 14100 ggacctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc agaggctagg ttatctccag cag gatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 tgatccagga gattgagagt ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 cagcaacaac caaagatcgg atctcaaata tgagcatcaa ggctttcaga cccccacacg 14400 atgatgttgc aaaattgctc aaasatatca acacaagcaa gcacaatctt cccatttcag 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggagg 14580 acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataag gagatactta 14640 aactaaacaa gtgcttctat aatagtgggg tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttgcc taacaaagat agctagagga actatagaga atcttatcga attggcagcc 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagt TATG tagggtccca ttatagagaa gtgaaccttg 15060 tataccctag atacagcaac ttcatatcta ctgaatctta tttggttatg acagatctca 15120 aggctaaccg gctaatgaat cctgaaaaga ttaagcagca tcatctgtga gataattgaa 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattgatcca ccatgatgtt gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accaaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tttgggggca cattcttctt tactccggga acagaaagtt gataaataag tttatccaga 15600 atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaag shits gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 ggagaccaaa taacagtcaa gaatggtata agttag cgg atacagtgcc ctgattaagg 15780 actaattggt tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa 15840 tagattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc tggt 15894 < 210 > 8 < 211 > 15894 < 212 > DNA < 213 > Measles virus < 400 > 8 accaaacaaa gttgggtaag gatagttcaa tcaatgatca tcttctagtg cacttaggat 60 tcaagatcct attatcaggg acaagagcag gattagggat atccgagatg gccacacttt 120 taaggagctt agcattgttc aaaagaaaca aggacaaacc acccattaca tcaggatccg 180 gtggagccat cagaggaatc aaacacatta ttatagtacc gattcctcaa aatccctgga 240 ttaccactcg atccagactt ctggaccggt tggtcaggtt aattggaaac ccggatgtga 300 gcgggcccaa actaacaggg gcactaatag gtatattatc cttatttgtg gagtctccag 360 gtcaattgat tcagaggatc accgatgacc ctgacgttag cataaggctg ttagaggttg 420 tccagagtga tctggcctta ccagtcacaa ccttcgcatc aagaggtacc aacatggagg 480 atgaggcgga caaatacttt tcacatgatg atccaattag tagtgatcaa tccaggttcg 540 gaacaaggaa gatggttcga atctcagata ttgaagtgca agaccctgag ggattcaaca 600 tgattctggg taccatccta gcccaaattt gggtcttgct cgcaaaggcg gttacggccc 660 cagacacggc agctgattcg gagctaagaa ggtggataaa gtacacccaa caaagaaggg 720 tagttggtga atttagattg gagagaaaat ggttggatgt ggtgaggaac aggattgccg 780 aggacctctc cttacgccga ttcatggtcg ctctaatcct ggatatcaag agaacacccg 840 gaaacaaacc caggattg ct gaaatgatat gtgacattga tacatatatc gtagaggcag 900 gattagccag ttttatcctg actattaagt ttgggataga aactatgtat cctgctcttg 960 gactgcatga atttgctggt gagttatcca cacttgagtc cttgatgaac ctttaccagc 1020 aaatggggga aactgcaccc tcctggagaa tacatggtaa aacaagttca ctcaattcag 1080 gtgcaggatc atáccctctg ctctggagct atgccatggg agtaggagtg gaacttgaaa 1140 actccatggg aggtttgaac tttggccgat cttactttga tccagcatat tttagattag 1200 ggcaagagat ggtaaggagg tcagctggaa aggtcagttc cacattggca tctgaactcg 1260 cgaggatgca gtatcactgc aggcttgttt cagagattgc aatgcatact actgaggaca 1320 agatcagtag agcggttgga cccagacaag cccaagtatc atttctacac ggtgatcaaa 1380 gctaccgaga gtgagaatga ttggggggca aggaagatag gagggtcaaa cagagtcgag 1440 gagaagccag ggagagctac agagaaaccg ggcccagcag agcaagtgat gcgagagctg 1500 aaccggcaca cccatcttcc cccctagaca ttgacactgc atcggagtcc agccaagatc 1560 cgcaggacag tcgaaggtca gctgacgccc tgcttaggct gcaagccatg gcaggaatct 1620 aggctcagac cggaagaaca ctatagtgta acggacaccc caatgacaga aatcttctag 1680 actaggtgcg 'agaggccgag gac cagaaca acatccgcct accctccatc attgttataa 1740 aaaacttagg aaccaggtcc acacagccgc cagcccatca accatccact cccacgattg 1800 gagccgatgg cagaagagca ggcacgccat gtcaaaaacg gactggaatg catccgggct 1860 ctcaaggccg agcccatcgg ctcactggcc atcgaggaag ctatggcagc atggtcagaa 1920 acccaggaca atatcagaca ggagcgagcc acctgcaggg aagagaaggc aggcagttcg 1980 ggtctcagca aaccatgcct ctcagcaatt ggatcaactg aaggcggtgc acctcgcatc 2040 gacctggaga cgcggtcagg gacgctgaaa gagcgatgac ccccccaaga ctttgggaat 2100 aatctccagg catcaagcac tgggttacag tgttattatg tttatgatca cagcggtgaa 2160 gcggttaagg gaatccaaga tgctgactct atcatggttc aatcaggcct tgatggtgat 2220 agcaccctat caggaggaga caatgaatct gaaaacagcg atgtggatat tggcgaacct 2280 gataccgagg gatatgctat cactgaccgg ggatctgctc ccatctctat ggggttcagg 2340 gcttctgatg ttgaaactgc agaaggaggg gagatccacg agctcctgag actccaatcc 2400 actttccgaa agaggcaaca gcttgggaaa actctcaatg ttcctccgcc cccggacccc 2460 gcacttccgg ggtagggcca aaaaagggca gacacccatt attagcctca cagacgcgag 2520 tttggaacgg agatcgcgtc ggtggtgcaa tttattgaca tcgaaagtca cccaatgtgc 2580 ccctcggaac catcagggcc aggtgcacct gcggggaatg tccccgagta tgtgagcaat 2640 tacaggagtg gccgcactga gacacccgaa tctggtacca caatctcccc gagatcccag 2700 aataatgaag aagggggaga ctattatgat gatgagctgt tctctgatgt ccaagatatt 2760 aaaacagcct tggccaaaat acacgaggat aatcagaaga taatctccaa gctagaatca 2820 tgaagggaga ctgctgttat agttgagtca attaagaagc agatcaacag gcaaaatatc 2880 ccctggaagg agcatatcca acacctctca agcatcatga tcgccattcc tggacttggg 2940 aaggatccca acgaccccac tgcagatgtc gaaatcaatc ccgacttgaa acccatcata 3000 ggcagagatt caggccgagc actggccgaa aacccgttgc gttctcaaga cagccgacaa 3060 ctccaaggaa tgacaaatgg acggaccagt tccagaggac agctgctgaa ggaatttcag 3120 tcgggaaaaa ccaaagccga gatgagctca gccgtcgggt ttgttcctga caccggccct 3180 gcatca cgca gtgtaatccg ctccattata aaatccagcc ggctagagga ggatcggaag 3240 cgttacctga tgactctcct tgatgatatc aaaggagcca atgatcttgc caagttccac 3300 cagatgctga tgaagataat aatgaagtag ctacagctca acttacctgc caaccccatg 3360 ccagtcgacc caactagtac aacctaaatc cattataaaa aacttaggag caaagtgatt 3420 gcctcccaag ttccacaatg acagagatct acgacttcga tgggacatca caagtcggca 3480 cgctccgata aagggtcgat caaccgacca cctacagtga tggcaggctg gtgccccagg 3540 tcagagtcat agatcctggt ctaggcgaca ggaaggatga atgctttatg tacatgtctc 3600 tgctgggggt tgttgaggac agcgatcccc tagggcctcc aatcgggcga gcatttgggt 3660 ccctgccctt aggtgttggc agatccacag caaagcccga aaagaggcca aaaactcctc 3720 ctgagcttga catagttgtt agacgtacag cagggctcaa tgaaaaactg gtgttctaca 3780 acaacacccc actaactctc ctcacacctt ggagaaaggt cctaacaaca gggagtgtct 3840 tcaacgcaaa ccaagtgtgc aatgcggtta atctgatacc gctcgatacc ccgcagaggt 3900 tccgtgttgt ttatatgagc atcacccgtc tttcggataa cgggtattac accgttccta 3960 gaagaatgct ggaattcaga tcggtcaatg cagtggcctt caacctgctg gtgaccctta 4020 ggattgacaa ggcgataggc cctggg AAGA tacagagcaa tcatcgacaa cttcctgagg 4080 caacatttat ggtccacatc gggaacttca ggagaaagaa gagtgaagtc tactctgccg 4140 attattgcaa aatgaaaatc gaaaagatgg gcctggtttt tgcacttggt gggatagggg 4200 tcacattaga gcaccagtct agcacaggca aaatgagcaa gactctccat gcacaactcg 4260 ggttcaagaa gaccttatgt tacccgctga tggatatcaa tgaagacctt aatcgattac 4320 tctggaggag cagatgcaag atagtaagaa tccaggcagt tttgcagcca tcagttcctc 4380 aagaattccg catttacgac gacgtgatca ccaaggacta taaatgatga ttcaaagttc 4440 tgtagaccgt agtgcccagc aatgcccgaa aacgaccccc ctcacaatga cagccagaag 4500 gcccggacaa aaaagccccc tccgaaagac tccactgacc aagcgagagg ccagccagca 4560 agcacgaaca gccgacggca ccagcacaga ccaggcggcc tacaaggcca acagccctga 4620 ccaccagcca ccccaatctg catcctcctc gtgggacccc cgaggaccaa cccccaaggc 4680 tgcccccgat ccaaaccacc aaccgcatcc ccaccacccc acccccagca cgggaaagaa 4740 attggaaggc ccctccccct cttcctcaac acaagaactc cacaaccgaa ccgcacaagc 4800 gaccgaggtg acccaaccgc aggcatccga ctccctagac agatcctctc tccccggcaa 4860 actaaacaaa acttagggcc aaggaacata c acacccaac ccccggccca agaacccaga 4920 cggcgccgcg cccccaaccc ccgacaacca gagggagccc ccaaccaatc ccgccggctc 4980 ccccggtgcc cacaggcagg gacaccaacc cccgaacaga cccagcacct aaccatcgac 5040 aatccaagac gggggggccc ccccaaaaaa aggcccccag gggccgacag ccagcaccgc 5100 acccacccca gaggaagccc cggcaaccaa cacacgacca accagaaccc agaccaccct 5160 gggccaccag ctcccagact cggccatcac cccgcagaaa ggaaaggcca caacccgcgc 5220 accccagccc cgatccggcg gggagccacc caacccgaac cagcacccaa gagcgatccc 5280 ccgaaccgca cgaaggaccc gtatcccaca aaggacatca gcctctccaa gtcccccggt 5340 ctcctcctct tctcgaaggg accaaaagat caatccacca cacccgacga cactcaactc 5400 cccaccccta aaggagacac cgggaatccc agaatcaaga ctcatccaat gtccatcatg 5460 ggtctcaagg tgaacgtctc tgccatattc atggcagtac tgttaactct ccaaacaccc 5520 accggtcaaa tccattgggg caatctctct aagatagggg tggtaggaat aggaagtgca 5580 agctacaaag ttatgactcg ttccagccat caatcattag tcataaaatt aatgcccaat 5640 ataactctcc tcaataactg cacgagggta gagattgcag aatacaggag actactgaga 5700 acagttttgg aaccaattag agatgcactt aatgcaatga cccagaatat aagaccggtt 5760 cagagtgtag cttcaagtag gagacacaag agatttgcgg gagtagtcct ggcaggtgcg 5820 gccctaggcg ttgccacagc tgctcagata ttgcacttca acagccggca ccagtccatg 5880 aagccatcga ctgaactctc caatctgaga gcgagcctgg aaactactaa tcaggcaatt 5940 gaggcaatca gacaagcagg gcaggagatg atattggctg ttcagggtgt ccaagactac 6000 atcaataatg agctgatacc gtctatgaac caactatctt gtgatttaat cggccagaag 6060 CTCGGG CTCA aattgctcag atactataca gaaatcctgt cattatttgg ccccagctta 6120 tatctgcgga cgggacccca gatatctatc caggctttga gctatgcgct tggaggagac 6180 atcaataagg tgttagaaaa gctcggatac agtggaggtg atttactggg catcttagag 6240 agcagaggaa taaaggcccg gataactcac gtcgacacag agtcctactt cattgtcctc 6300 agtatagcct atccgacgct gtccgagatt aagggggtga ttgtccaccg gctagagggg 6360 gtctcgtaca acataggctc tcaagagtgg tataccactg tgcccaagta tgttgcaacc 6420 caagggtacc ttatctcgaa ttttgatgag tcatcgtgta ctttcatgcc agaggggact 6480 gtgtgcagcc aaaatgcctt gtacccgatg agtcctctgc tccaagaatg cctccggggg 6540 tacaccaagt cctgtgctcg tacactcgta tccgggtctt ttgggaaccg gttcatttta 6600 acctaatagc tcacaaggga caattgtgca tcaatccttt gcaagtgtta cacaacagga 6660 acgatcatta atcaagaccc tgacaagatc ctaacataca ttgctgccga taactgcccg 6720 gtagtcgagg tgaacggcgt gaccatccaa gtcgggagca ggaggtatcc agacgctgtg 6780 tacttgcaca gaattgacct cggtcctccc atattattgg cgtagggaca agaggttgga 6840 aatctgggga atgcaattgc taagttggag gatgccaagg aattgttgga gtcatcggac 6900 cagatattga g gagtatgaa aggtttatcg agcacttgca tagtctacat cctgattgca 6960 gtgtgtcttg gagggttgat agggatcccc gctttaatat gttgctgcag ggggcgttgt 7020 aacaaaaagg gagaacaagt tggtatgtca agaccaggcc taaagcctga tcttacggga 7080 acatcaaaat cctatgtaag gtcgctctga tcctctacaa ctcttgaaac acaaatgtcc 7140 ctcttcgtca cacaagtctc tcaagcaacc accgcaccca gcatcaagcc cacctgaaat 7200 tatctccggc ttccctctgg ccgaacaata tcggtagtta attaaaactt agggtgcaag 7260 atcatccaca atgtcaccac aacgagaccg gataaatgcc ttctacaaag ataaccccca 7320 tcccaaggga agtaggatag tcattaacag agaacatctt atgattgata gaccttatgt 7380 tttgctggct gttctgtttg tcatgtttct gagcttgatc gggttgctag ccattgcagg 7440 cattagactt catcgggcag ccatctacac cgcagagatc cataaaagcc tcagcaccaa 7500 actaactcaa tctagatgta tcgagcatca ggtcaaggac gtgctgacac cactcttcaa 7560 aatcatcggt gatgaagtgg gcctgaggac acctcagaga ttcactgacc tagtgaaatt 7620 catctctgac aagattaaat tccttaatcc ggatagggag tacgacttca gagatctcac 7680 ttggtgtatc aacccgccag agagaatcaa attggattat gatcaatact gtgcagatgt 7740 gagctca ggctgctgaa tga atgcattggt gaactcaact ctactggaga ccagaacaac 7800 ctagctgtct caatcagttc ctgctcaggg caaagggaaa tcagaggtca cccactacaa 7860 attctcaaac atgtcgctgt ccctgttaga cttgtattta ggtcgaggtt acaatgtgtc 7920 atctatagtc actatgacat cccagggaat gtatggggga acttacctag tggaaaagcc 7980 taatctgagc agcaaaaggt cagagttgtc acaactgagc atgtaccgag tgtttgaagt 8040 aggtgttatc agaaatccgg gtttgggggc tccggtgttc catatgacaa actatcttga 8100 gcaaccagtc agtaatgatc tcagcaactg tatggtggct ttgggggagc tcaaactcgc 8160 agccctttgt caccgggaag attctatcac aattccctat cagggatcag ggaaaggtgt 8220 cagcttccag ctcgtcaagc taggtgtctg gaaatcccca accgacatgc aatcctgggt 8280 acggatgatc caccttatca cagtgataga caggctttac ctctcatctc acagaggtgt 8340 tatcgctgac aatcaagcaa aatgggctgt cccgacaaca cgaacagatg acaagttgcg 8400 aatggagaca tgcttccaac aggcgtgtaa gggtaaaatc caagcactct gcgagaatcc 8460 cgagtgggca ccattgaagg ataacaggat tccttcatac ggggtcttgt ctgttgatct 8520 gagtctgaca gttgagctta aaatcaaaat tgcttcggga ttcgggccat tgatcacaca 8580 cggttcaggg atggacctat acaaatccaa ccacaacaat gtgtattggc tgactatccc 8640 accaatgaag aacctagcct taggtgtaat caacacattg gagtggatac cgagattcaa 8700 ggttagtccc tacctcttca atgtcccaat taaggaagca ggcgaagact gccatgcccc 8760 aacataccta cctgcggagg tggatggtga tgtcaaactc agttccaatc tggtgattct 8820 acctggtcaa gatctccaat atgttttggc aacct'acgat acttccaggg ttgaacatgc 8880 tgtggtttat tacgtttaca gcccaagccg ctcattttct tacttttatc cttttaggtt 8940 ggggtcccca gcctataaag tcgaattaca agtggaatgc ttcacatggg accaaaaact 9000 ctggtgccgt cacttctgtg tgcttgcgga ctcagaatct ggtggacata tcactcactc 9060 tgggatggtg ggcatgggag tcagctgcac agtcacccgg gaagatggaa ccaatcgcag 9120 atagggctgc tagtgaacta atctcatgat gtcacccaga catcaggcat acccactagt 9180 gtgaaataga catcagaatt aagaaaaacg tagggtccaa gtggttcccc gttatggact 9240 cgctatctgt caaccagatc ttataccctg aagttcacct agatagcccg atagttacca 9300 ataagatagt agccatcctg gagtatgctc gagtccctca cgcttacagc ctggaggacc 9360 ctacactgtg tcagaacatc aagcaccgcc taaaaaacgg attttccaac caaatgatta 9420 taaacaatgt ggaagttggg aatgt CATCA agtccaagct taggagttat ccggcccact 9480 ctcatattcc atatccaaat tgtaatcagg atttatttaa catagaagac aaagagtcaa 9540 cgaggaagat ccgtgaactc ctcaaaaagg ggaattcgct gtactccaaa gtcagcgata 9600 aggttttcca atgcttaagg gacactaact cacggcttgg cctaggctcc gaattgaggg 9660 aggacatcaa ggagaaagtt attaacttgg gagtttacat gcacagctcc cagtggtttg 9720 agccctttct gttttggttt acagtcaaga ctgagatgag gtcagtgatt aaatcacaaa 9780 cccatacttg ccataggagg agacacacac ctgtattctt cactggtagt tcagttgagt 9840 tgctaatctc tcgtgacctt gttgctataa tcagtaaaga gtctcaacat gtatattacc 9900 tgacatttga actggttttg atgtattgtg ggggaggtta atgtcataga atgacagaga 9960 ccgctatgac tattgatgct 'aggtatacag agcttctagg tacatgtgga aagagtcaga 10020 aactgataga tggtttcttc cctgcactcg ggaatccaac ttatcaaatt gtagccatgc 10080 tggagcctct ttcacttgct tacctgcagc tgagggatat aacagtagaa ctcagaggtg 10140 ctttccttaa ccactgcttt actgaaatac atgatgttct tgaccaaaac gggttttctg 10200 atgaaggtac ttatcatgag ttaattgaag ctctagatta actgatgaca cattttcata 10260 tacatctgac aggggagatt ttctc atttt tcagaagttt cggccacccc agacttgaag 10320 cagtaacggc tgctgaaaat gttaggaaat acatgaatca gcctaaagtc attgtgtatg 10380 agactctgat gaaaggtcat gccatatttt gtggaatcat aatcaacggc tatcgtgaca 10440 cagttggcca ggcacggagg ccgctgaccc tccccctgca tgctgcagac acaatccgga 10500 atgctcaagc ttcaggtgaa gggttaacac atgagcagtg cgttgataac tggaaatctt 10560 ttgctggagt gaaatttggc tgctttatgc ctcttagcct ggatagtgat ctgacaatgt 10620 acctaaagga caaggcactt gctgctctcc aaagggaatg ggattcagtt tacccgaaag 10680 agttcctgcg ttacgaccct cccaagggaa ccgggtcacg gaggcttgta gatgttttcc 10740 ttaatgattc gagctttgac ccatatgatg tgataatgta tgttgtaagt ggagcttacc 10800 tccatgaccc tgagttcaac ctgtcttaca gcctgaaaga aaaggagatc aaggaaacag 10860 gtagactttt tgctaaaatg acttacaaaa tgagggcatg ccaagtgatt gctgaaaatc 10920 taatctcaaa cgggattggc aaatatttta aggacaatgg gatggccaag gatgagcacg 10980 atttgactaa ggcactccac actctagctg tctcaggagt ccccaaagat ctcaaagaaa 11040 gtcacagggg ggggccagtc ttaaaaacct actcccgaag cccagtccac acaagtacca 11100 ggaacgtgag agcagcaaaa gggtttatag ggttccctca agtaattcgg caggaccaag 11160 acactgatca tccggagaat atggaagctt acgagacagt cagtgcattt atcacgactg 11220 atctcaagaa gtactgcctt aattggagat atgagaccat cagcttgttt gcacagaggc 11280 taaatgagat ttacggattg ccctcatttt tccagtggct gcataagagg cttgagacct 11340 ctgtcctgta tgtaagtgac cctcattgcc cccccgacct tgacgcccat atcccgttat 11400 ataaagtccc caatgatcaa atcttcatta agtaccctat gggaggtata gaagggtatt 11460 gtcagaagct gtggaccatc agcaccattc cctatctata cctggctgct tatgagagcg 11520 gagtaaggat tgcttcgtta gtgcaagggg acaatcagac catagccgta acaaaaaggg 11580 tacccagcac atggccctac aaccttaaga aacgggaagc tgctagagta actagagatt 11640 actttgtaat tcttaggcaa aggctacatg atattggcca tcacctcaag gcaaatgaga 11700 caattgtttc atcacatttt tttgtctatt caaaaggaat atattatgat gggctacttg 11760 tgtcccaatc actcaagagc atcgcaagat gtgtattctg gtcagagact atagttgat g 11820 aaacaagggc agcatgcagt aatattgcta caacaatggc taaaagcatc gagagaggtt 11880 atgaccgtta ccttgcatat tccctgaacg tcctaaaagt gatacagcaa attctgatct 119.40 ctcttggctt cacaatcaat tcaaccatga cccgggatgt agtcataccc ctcctcacaa 12000 acaacgacct cttaataagg atggcactgt tgcccgctcc tattgggggg atgaattatc 12060 tgaatatgag caggctgttt gtcagaaaca tcggtgatcc agtaacatca tcaattgctg 12120 atctcaagag aatgattctc gcctcactaa tgcctgaaga gaccctccat caagtaatga 12180 cacaacaacc gggggactct tcattcctag actgggctag cgacccttac tcagcaaatc 12240 ttgtatgtgt ccagagcatc actagactcc tcaagaacat aactgcaagg tttgtcctga 12300 tccatagtcc aaacccaatg ttaaaaggat tattccatga tgacagtaaa gaagaggacg 12360 agggactggc ggcattcctc atggacaggc atattatagt acctagggca gctcatgaaa 12420 tagtgtcaca tcctggatca ggggcaagag agtctattgc aggcatgctg gataccacaa 12480 aaggcctgat tcgagccagc atgaggaagg gggggttaac ctctcgagtg ataaccagat 12540 tgactatgaa tgtccaatta cagggatggt caattcagag ggaagaaaga gctattgaca 12600 gaaatgtcct cattgacaaa gagtcatgtt cagtgcagct ggcgagagct ctaagaagcc 12660 atatgtgggc gaggctagct cgaggacggc ctatttacgg ccttgaggtc cctgatgtac 12720 tagaatctat gcgaggccac cttattcggc gtcatgagac atgtgtcatc tgcgagtgtg 12780 gatcagtcaa ctacggatgg ttttttgtcc cctcgggttg ccaactggat gatattgaca 12840 atccttgaga aggaaacatc gtcccatata ttggttctac agaacagaca cactgatgag 12900 tgaagcttgc cttcgtaaga gccccaagtc gatccttgcg atctgctgtt agaatagcaa 12960 cagtgtactc atgggcttac ggtgatgatg atagctcttg gaacgaagcc tggttgttgg 13020 ctaggcaaag ggccaatgtg agcctggagg agctaagggt gatcactccc atctcaactt 13080 cgactaattt agcgcatagg ttgagggatc gtagcactca agtgaaatac tcaggtacat 13140 cccttgtccg agtggcgagg tataccacaa tctccaacga caatctctca tttgtcatat 13200 cagataagaa ggttgatact aactttatat accaacaagg aatgcttcta gggttgggtg 13260 ttttagaaac attgtttcga ctcgagaaag ataccggatc atctaacacg gtattacatc 13320 ttcacgtcga aacagattgt tgcgtgatcc cgatgataga tcatcccagg atacccagct 13380 cccgcaagct agagctgagg gcagagctat gtaccaaccc attgatatat gataatgcac 13440 cagagataca ctttaattga acaaggctat cca acacccagag taggagg caccttgtgg 13500 atggtccaca aatttgttac ccccaactat atcacatttt agctaagtcc acagcactat 13560 cctggtaaca ctatgattga aaatttgaga aggaccatat gaatgaaatt tcagctctca 13620 taggggatga cgatatcaat agtttcataa ctgagtttct gctcatagag ccaagattat 13680 cttgggccag tcactatcta tgtgcggcca atttgatgta tcaattgggc cattatcata 13740 gaccatcagg gaaatatcag atgggtgagc tgttgtcatc gttcctttct agaatgagca 13800 aaggagtgtt taaggtgctt gtcaatgctc taagccaccc aaagatctac aagaaattct 13860 ggcattgtgg tattatagag cctatccatg gtccttcact aacttgcaca tgatgctcaa 13920 caactgtgtg caacatggtt tacacatgct atatgaccta cctcgacctg ttgttgaatg 13980 agagttcaca aagagttaga tttctcttgt gtgaaagcga cgaggatgta gtaccggaca 14040 catccaggca gattcgacaa aaacacttat gtgttctggc agatttgtac tgtcaaccag 14100 gggcctgccc accaattcga ggtctaagac cggtagagaa atgtgcagtt ctaaccgacc 14160 atatcaaggc agaggctagg ttatctccag caggatcttc gtggaacata aatccaatta 14220 ttgtagacca ttactcatgc tctctgactt atctccggcg aggatcgatc aaacagataa 14280 gattgagagt tgatccagga ttcattttcg acgccctcgc tgaggtaaat gtcagtcagc 14340 caaagatcgg cagcaacaac atctcaaata tgagcatcaa ggctt shits cccccacacg 14400 atgatgttgc aaaattgctc aaagatatca acacaagcaa gcacaatctt cccatttcag 14460 ggggcaatct cgccaattat gaaatccatg ctttccgcag aatcgggttg aactcatctg 14520 cttgctacaa agctgttgag atatcaacat taattaggag atgccttgag ccaggggagg 14580 acggcttgtt cttgggtgag ggatcgggtt ctatgttgat cacttataag gagatactta 14640 aactaaacaa gtgcttctat aatagtgggg 'tttccgccaa ttctagatct ggtcaaaggg 14700 aattagcacc ctatccctcc gaagttggcc ttgtcgaaca gtaggtaata cagaatggga 14760 ttgtcaaagt gctctttaac gggaggcccg aagtcacgtg ggtaggcagt gtagattgct 14820 tcaatttcat agttagtaat atccctacct ctagtgtggg gtttatccat tcagatatag 14880 agaccttgcc taacaaagat agctagagga actatagaga atcttatcga attggcagcc 14940 tggctctgct cctgggcaaa ataggatcaa tactggtgat taagcttatg cctttcagcg 15000 gggattttgt tcagggattt ataagttatg tagggtctta ttatagagaa gtgaaccttg 15060 tataccctag atacagcaac ttcatatcta ctgaatctta tttggttatg acagatctca 15120 aggctaaccg gctaacgaat cctgaaaaga tt aagcagca tcatc gataattgaa GTGA 15180 ggacttcacc tggacttata ggtcacatcc tatccattaa gcaactaagc tgcatacaag 15240 caattgtggg agacgcagtt agtagaggtg atatcaatcc tactctgaaa aaacttacac 15300 ctatagagca ggtgctgatc aattgcgggt tggcaattaa cggacctaag ctgtgcaaag 15360 aattgatcca ccatgatg.t gcctcagggc aagatggatt gcttaattct atactcatcc 15420 gttggcaaga tctacaggga ttcaaagaca accgaagaag tcaacaaggg atgttccacg 15480 cttaccccgt attggtaagt agcaggcaac gagaacttat atctaggatc acccgcaaat 15540 tttgggggca cattcttctt tactccggga acagaaagtt gataaataag tttatccaga 15600 atctcaagtc cggctatctg atactagact tacaccagaa tatcttcgtt aagaatctat 15660 ccaagtcaga gaaacagatt attatgacgg ggggtttgaa acgtgagtgg gtttttaagg 15720 ggagaccaaa taacagtcaa gaatggtata - agttagtcgg atacagtgcc ctgattaagg 15780 actaattgat tgaactccgg aaccctaatc ctgccctagg tggttaggca ttatttgcaa 15840 tatattaaag aaaactttga aaatacgaag tttctattcc cagctttgtc TGGT 15894 < 210 > 9 < 211 > 15218 < 212 > DNA < 213 > human respiratory syncytial virus < 400 > 9 atgcgtacta acgcgaaaaa cattcgaaaa caaacttgca aaatggggca aataagaact 60 tgataagtgc tatttaagtc taaccttttc aatcagaaat ggggtgcaat tcactgagca 120 tgataaaggt tagattacaa aatttatttg acaatgacga agtagcattg ttaaaaataa 180 tgataaatta catgttatac attcttctga ccaatgcatt agccaaagca gcaatacata 240 aaacggcata caattaaatt gtttttatac atgttataac aagcagtgaa gtgtgccctg 300 ataacaatat tgtagtgaaa tctaacttta caacaatgcc aatactacaa aatggaggat 360 acatatggga attgattgag ttgacacact gctctcaatt aaacggttta atggatgata 420 attgtgaaat caaattttct aaaagactaa gtgactcagt aatgactaat tatatgaatc 480 aaatatctga cttacttggg cttgatctca attcatgaat tatgtttagt ctaattcaat 540 agacatgtgt ttattaccat tttagttaat ataaaaactc atcaaaggga aatggggcaa 600 ataaactcac ctaatcaatc aaaccatgag cactacaaat gacaacacta ctatgcaaag 660 acagacatga attgatgatc gacccctgtc aatggattca ataataacat ctcttaccaa 720 agaaatcatc acacacaaat tcatatactt gataaacaat gaatgtattg taagaaaact 780 tgatgaaaga caagctacat ttacattctt agtcaattat gagatgaagc tactgcacaa 840 agtagggagt accaaataca aaaaatacac tgaatataat acaaaatatg gcactttccc 900 catgcctata tttatcaatc acggcgggtt tctagaatgt attggcatta agcctacaaa 960 ataatataca acacactcct aatatgacct caacccgtga attccaacaa aaaaaccaac 1020 ccaaccaaac caaactattc ctcaaacaac agtgctcaat agttaagaag gagctaatcc 1080 ttaaaaataa attttagtaa aagtaaagcc aataacataa attggggcaa atacaaagat 1140 ggctcttagc aaagtcaagt tgaatgatac attaaataag gatcagctgc tgtcatccag 1200 attcaacgta caaatacact gtacaggaga taatattgac atgatgtgca actcccaatt 1260 aaaacaccta aaca aactat gtggtatgct attaatcact gaagatgcaa atcataaatt 1320 cacaggatta ataggtatgt tatatgctat gtccaggt.ta ggaagggaag acactataaa 1380 gatgctggat gatacttaaa atcatgttaa gtagatataa agctaatgga caacatatcg 1440 tcaagatata aatggaaagg aaatgaaatt cgaagtatta acattatcaa gcttgacatc 1500 agaaatacaa gtcaatattg agatagaatc tagaaagtcc tacaaaaaaa tgctaaaaga 1560 gtggctccag gatgggagaa aatataggca tgattctcca gactgtggga tgataatact 1620 gtgtatagct gcacttgtga taaccaaatt agcagcagga gacagatcag gtcttacagc 1680 agtaattagg atgtcttaaa agggcaaaca aaacgataca aaacgaaata agggcctcat 1740 atagctaaca accaaaggat gtttttatga agtgtttgaa atcttataga aaacaccctc 1800 cactttggca tgttttcgtg ttgcacaatc atccacaaga gggggtagta gagttgaagg 1860 ggattgttta aatctttgca tgaatgccta tggttcaggg caagtaatgc taagatgggg 1920 agttttagcc aaatctgtaa aaaatatcat gctaggacat gctagtgtcc aggcagaaat 1980 ggagcaagtt gtggaagtct atgagtatgc acagaagttg ggaggagaag ctggattcta 2040 ccatatattg aacaatccaa aagcatcatt gctgtcatta actcaatttc ccaacttctc 2100 aagtgtggtc ctaggcaat g cagcaggtct aggcataatg ggagagtata gaggtacacc 2160 aagaaaccag gatctttatg atgcagctaa agcatatgca gagcaactca aagaaaatgg 2220 agtaataaac tacagtgtat tagacttaac agcagaagaa taaagcatca ttggaagcca 2280 actcaacccc aaagaagatg atgtagagct ttaagttaac aaaaaatacg gggcaaataa 2340 gtcaacatgg agaagtttgc acctgaattt catggagaag atgcaaataa caaagctacc 2400 aaattcctag aatcaataaa gggcaagt c gcatcatcca aagatcctaa gaagaaagat 2460 agcataatat ctgttaactc aatagatata gaagtaacta aagagagccc gataacatct 2520 ggcaccaaca tcatcaatcc aacaagtgaa gccgacagta ccccagaaac aaaagccaac 2580 aacccctagt tacccaagaa gaagatctca aagcttcaaa ccccaagtga caaccctttt 2640 tctaagttgt acaaggaaac aatagaaaca tttgataaca atgaagaaga atctagctac 2700 tcatatgaag agataaatga tcaaacaaat gacaacatta cagcaagact agatagaatt 2760 gatgaaaaat taagtgaaat attaggaatg ctccatacat tagtagttgc aagtgcagga 2820 cccacttcag ctcgcgatgg aataagagat gctatggttg gtctaagaga agagatgata 2880 gaaaaaataa gagcggaagc attaatgacc aatgataggt tagaggctat ggcaagactt 2940 aggaatgagg aaagcgaaaa aatg gcaaaa gacacctcag atgaagtgtc tcttaatcca 3000 aattgagtga acttccaaaa gacaacgata cttgttggaa gtgacaatga tctatcactt 3060 gatgattttt gatcagcgat caactcactc agcaatcaac aacatcaata aaacagacat 3120 caatccattg aatcaactgc cagaccgaac aaacaaacgt ccatcagtag aaccaccaac 3180 caatcaatca accaattgat caatcagcaa cccgacaaaa ttaacaatat agtaacaaaa 3240 atggggcaaa aaagaacaag tacgtgaaca tatggaaaca aggctccaca agcttcacga 3300 tacacagcag ctgttcagta caatgttcta atgatcctgc gaaaaagatg atcactaaca 3360 atatgggtgc ctatgttcca gtcatctgtg ccagcagact agaacttgca tgctcataaa 3420 tactagtgaa agcatcaata gcagatctct acgcccaaag gaccttcact acgagtcacg 3480 gaagtgctgt attaactcaa gctggctcaa atgcctagta atttcatcat aagcgcaaat 3540 gtatcattag atgaaagaag caaattagca tatgatgtaa tgaaatcaaa ctacaccttg 3600 gcatgcagtc taacatgctt aaaagtaaaa agtatgttaa ctacagtcaa agatcttacc 3660 atgaagacat tcaaccccac tcatgagatc attgctctat gtgaatttga aaatattatg 3720 acatcaaaaa gagtaataat accaacctat ctaagatcaa ttagtgtcaa gaacaaggat 3780 ctgaactcac tagaaaatat agcaaccacc gaattcaaaa atgctatcac caatgcaaaa 3840 attattcctt atgcaggatt agtgttagtt atcacagtta ctgacaataa aggagcattc 3900 aaatatatca aaccacagag tcaatttata gtagatcttg gtgcctacct agaaaaagag 3960 agcatatatt atgtgactac taattggaag catacagcta aatcaaacca cacgtttttc 4020 ctagaggatt aaacttaatt atcaacactg aatgacaggt ccacatatat cctcaaacta 4080 ccaaacatca cacactatat taaacatcta cactacacac ttcatcacac aaaccaatcc 4140 cactca AAAT ccaaaatcac taccagccac tatctgctag acctagagtg cgaataggta 4200 aataaaacca aaatatgggg taaatagaca ttagttagag ttcaatcaat cttaacaacc 4260 atttataccg ccaattcaac taaatcttaa acatatacta aatgggaaat acatccatca 4320 cacaagcaaa caatagaatt ttttggccct attttacact aatacatatg atcttaactc 4380 taatcttttt actaattata atcactatta tgattgcaat actaaataag ctaagtgaac 4440 ataaagcatt ctgtaacaaa actcttgaac taggacagat gtatcaaatc aacacataga 4500 gttctaccat tatgctgtgt caaattataa tcctgtatat ataaacaaac aaatccaatc 4560 ttctcacaga gtcatggtgt cgcaaaacca cgctaactat catggtagca tagagtagtt 4620 atttaaaaat taacataatg atgaattgtt agtatgagat caaaaacaac attggggcaa 4680 atgcaaccat gtccaaacac aagaatcaac gcactgccag gactctagaa aagacctggg 4740 atactcttaa tcatctaatt gtaatatcct cttgtttata cagattaaat ttaaaatcta 4800 tagcacaaat agcactatca gttttggcaa tgataatctc aacctctctc ataattgcag 4860 ccataatatt catcatctct gccaatcaca aagttacact aacaacggtc acagttcaaa 4920 caataaaaaa ccacactgaa aaaaacatca ccacctaccc tactcaagtc tcaccagaaa 4980 gggttagttc to tccaagcaa cccacaacca catcaccaat ccacacaagt tcagctacaa 5040 tacaaaatca catcacccaa gaaacacacc atacaacagc ggcagaacca acaaaccaaa 5100 ccacttcaac acagaccaac aagccaagca caaaaccacg tccaaaaaat ccaccaaaaa 5160 ccattttgaa aagatgatta gtgttcaact tcgttccctg cagtatatgt ggcaacaatc 5220 aactttgcaa atccatctgc aaaacaatac caagcaacaa accaaagaag aaaccaacca 5280 aaacaaacca tcaaacccac accaccaaaa ccacaaacaa aagagaccca aaaacaccag 5340 gaaaaaagaa ccaaaacgac actaccacca acccaacaaa aaaactaacc ctcaagacca 5400 cagaaagaga caccagcacc tcacaatcca cacaaccaca ctgcactcga ttaaaacaca 5460 gcaatccctc cagtccaaca ctctcaacca cccccgaaaa tccacacaaa cacacccaac 5520 cacccacagc atccgagccc tccacaccaa actccaccca aaaaacccag ccacatgctt 5580 agttattcaa aaactacatc ttagcagaga accgtgatct atcaagcaag aacgaaatta 5640 aacctggggc aaataaccat ggagttgatg atccacaagt caagtgcaat cttcctaact 5700 atgcattgta cttgctatta cctcacctca agtcagaaca gttttaccaa taactgagga 5760 tcgacatgta gtgcagttag cagaggttat tttagtgctt taagaacagg ttggtatact 5820 agtgtcataa caataga att aaagaaacca aagtaatata aatgcaatgg aactgacact 5880 ttatgaaaca aaagtaaaac agaattagat aagtataaga atgcagtaac agaattacag 5940 ctacttatgc aaaacacacc agctgtcaac aaccgggcca gaagagaagc accacagtat 6000 atgaactaca caatcaatac cactaaaaac ctaaatgtat gaagaggaaa caataagcaa 6060 cgaagatttc taggcttctt gttaggtgtg ggatctgcaa tagcaagtgg tatagctgta 6120 tacaccttga tcaaaagttc aacaagatca aggagaagtg gttgtctaca aaaatgcttt 6180 aacaaagctg tagtcagttt atcaaatggg gtcagtgttt taaccagcaa agtgttagat 6240 acataaataa ctcaagaatt ccaattatta cccatagtaa atcaacagag ctgtcgcatc 6300 tccaacattg aaacagttat agaattccag cagaagaaca gcagattgtt ggaaatcacc 6360 agagaattta aggtgtaaca gtgtcaatgc acacctttaa gcacttacat gttgacaaac 6420 agtgagttac tatcattaat caatgatatg cctataacaa atgatcagaa aaaattaatg 6480 tcaagcaatg ttcagatagt aaggcaacaa agttattcca tcatgtctat aataaaggaa 6540 gaagtccttg catatgttgt acagctgcct atctatggtg taatagatac accttgctgg 6600 aaattgcaca catcgcctct atgcactacc aacatcaaag aaggatcaaa tatttgttta 6660 acaaggactg atagaggatg gtattgtgat aatgcaggat cagtatcctt ctttccacag 6720 gtaaagtaca gctgacactt gtattttgtg gtccaatcga acactatgaa cagtttgaca 6780 ttaccaagtg aagtcagcct ttgtaacact attccaagta gacatattca tgactgcaaa 6840 attatgacat caaaaacaga cataagcagc tcagtaatta cttctcttgg agctatagtg 6900 tcatgctatg gtaaaactaa tccaacaaaa atgcactgca atcgtgggat tataaagaca 6960 ttttctaatg gttgtgacta tgtgtcaaac aaaggagtag atactgtgtc agtgggcaac 7020 actttatact atgtaaacaa gctggaaggc aagaaccttt atgtaaaagg ggaacctata 7080 ataaattact atgaccctct agtgtttcct tctgatgagt ttgatgcatc aatatctcaa 7140 aaatcaatca gtcaatgaaa aagtttagct tttattcgta gatctgatga attactacat 7200 aatgtaaata ctggcaaatc tactacaaat attatgataa ctacaattat tatagtaatc 7260 attgtagtat tgttatcatt aatagctatt ggtttactgt tgtattgtaa agccaaaaac 7320 cactaagcaa acaccagtta agaccaacta agtggaatca attcagcaaa ataatattgc 7380 tagacaaaaa accacctgat catgtttcaa caacaatctg ctgaccacca atcccaaatc 7440 aaatatttca aacttacaac acatcacagt acaggctgaa tcatttcctc acatcatgct 7500 ctaagctaga acccacataa tcctta ACTT atagttacat aaaaacctca agtatcacaa 7560 aatcaacaca tcaaccacta tcattcacaa aattaacagc tggggcaaat atgtcgcgaa 7620 gaaatccttg taaatttgag attagaggtc attgcttgaa tgtcactaca tggtagaaga 7680 gtcataatta ctttgaatgg cctcctcatg cattactagt gaggcaaaac ttcatgttaa 7740 acaagatact caagtcaatg gacaaaagca tagacacttt gtctgaaata agtggagctg 7800 tagaacagaa ctgaactgga gaatatgctc ttggtatagt gagagttaca tggagtgcta 7860 taggatctat aaacaacata acaaaacaat cagcatgtgt tgctatgagt aaacttctta 7920 ttgagatcaa tagtgatgac attaaaaagc ttagagataa tgaagaaccc aattcaccta 7980 agataagagt gtacaatact gttatatcat acattgagag caatagaaaa aacaacaagc 8040 aaaccatcca tctgctcaag agactaccag cagacgtgct ataaagaaca gaagaagaca 8100 cattagatat ccacaaaagc ataaccataa gcaatccaaa agagtcaact gtgaatgatc 8160 aaaatgacca aaccaaaaat aatgatatta ccggataaat atccttgtag tatatcatcc 8220 atattgatct caagtgaaag catggttgct acattcaatc ataaaaacat áttacaattt 8280 aaccataact atttggataa ccaccagcgt ttattaaatc atatatttga tgaaattcat 8340 tggacaccta aaaacttatt agatgccact caacaatttc tccaacatct taacatccct 8400 gaagatatat atacagtata tatattagtg tcataatgct tgaccataac gactctatgt 8460 catccaacca taaaactatt ttgataaggt tatgggacaa aatggatccc attattaatg 8520 gaaactctgc taatgtgtat ctaactgata gttatttaaa aggtgttatc tctttttcag 8580 agtgtaatgc tttagggagt tatcttttta acggccctta tcttaaaaat gattacacca 8640 acttaattag tagacaaagc ccactactag tcttaaaaaa agcatatgaa ctaactataa 8700 aatatctaga cacagtcatt tatcataaag gtgaactgaa attagaagaa ccaacttatt 8760 acttatgaca tccagtcatt tataaaagta tgtcctcgtc tgaacaaatt gctacaacta 8820 aaaaataata acttacttaa cgaagagcca tagaaataag tgatgtaaag gtgtacgcca 8880 actaggatta tcttgaataa aaggaaaagg acagagttaa gcccaacaat aattcaggtg 8940 agtacttaca atgaaaactc accataatta aagatgatat actttcggct gtggaaaaca 9000 tacaaattca atcaatcata gacaaaagtc actcagtaaa actatcaaaa tcaaaatatc 9060 caacactctt gaaaaaattg atgtgttcaa tgcaácatcc tccatcatgg ttaatacact 9120 atatacaaaa ggttcaattt ttaaataaca tattaacaca atatcgatca aatgaggtaa 9180 aaagtcatgg gtttatatta atagataatc aaactttaag tggttttcag tttattttaa 9240 atcaatatgg ttgtatcgtt tatcataaag gactcaaaaa aatcacaact actacttaca 9300 atcaattttt gacatggaaa gacatcagcc ttagcagatt aaatgtttgc ttaattactt 9360 ggataagtaa ttgtttaaat acattaaaca aaagcttagg gctgagatgt ggattcaata 9420 atgttgtgtt atcacaatta tttctttatg gagattgtat actgaaatta tttcataatg 9480 aaggcttcta cataataaaa gaagtagagg gatttattat gtctttaatt ctaaacataa 9540 cagaagaaga tcaatttagg aaacgatttt ataatagcat gctaaataac atcacagatg 9600 cagctattaa ggctcaaaag gacctactat caagagtatg tcacacttta ttagacaaga 9660 taatatcata cagtgtctga aatggtaaat ggataatcct attaagtaaa tttcttaaat 9720 tgattaagct tgcaggtgat aataatctca ataacttgag tgagctatat tttctcttca 9780 gaatctttgg acatccaatg gtcgatgaaa gacaagcaat ggattctgta agaattaact 9840 gtaatgaaac taagttctac ttattaagta gtctaagtac attaagaggt gctttcattt 9900 Ataga atcat aaaagggttt gtaaatacct acaacagatg gcccacctta aggaatgcta 9960 ttgtcctacc tctaagatgg ttaaactact ataaacttaa tacttatcca tctctacttg 10020 aaatcacaga aaatgatttg attattttat caggattgcg gttctatcgt gagtttcatc 10080 agtggatctt tgcctaaaaa taaatgacaa gaaatgataa agccatttca cctccaaaag 10140 atctaatatg gactagtttt cctagaaatt acatgccatc acatatacaa aattatatag 10200 aacatgaaaa gttgaagttc tctgaaagcg acagatcgag aagagtacta gagtattact 10260 tgagagataa taaattcaat gaatgcgatc tatacaattg tgtagtcaat caaagctatc 10320 tcaacaactc taatcacgtg ctggtaaaga gtatcactaa aagagagctc agtgtaggta 10380 tatgcaacca gaatgtttgc ggtatgttta ggcaaatcca aatcttagca gagaaaatga 10440 tagctgaaaa tattttacaa ttcttccctg agagtttgac aagatatggt gatctagagc 10500 attagaatta ttcaaaagat aaagcaggaa taagcaacaa tataatgata gtcaaatcgt 10560 ttatatcagt actacaacaa aaatgttcta tcattacaga tcttagcaaa ttcaatcagg 10620 tgaaacatca catttagata tgtatctgca gtgatgtatt agatgaactg catggagtac 10680 aatctctgtt ctcttggttg catttaacaa tacctcttgt tgtacatata cacaataata 1074 0 gacatgcacc tcctttcata aaggatcatg ttgttaatct taatgaggtt gatgaacaaa 10800 gtggattata cagatatcat atgggtggta ttgagggctg gtgtcaaaaa ctgtggacca 10860 ttgaagctat atcattatta gatctaatat ctctcaaagg gaaattctct atcacagctc 10920 tgataaatgg tgataatcag tcaattgata taagcaaacc agttagactt atagagggtc 10980 agacccatgc acaagcagat tatttgttag cattaaatag ccttaaattg ttatataaag 11040 agtatgcagg tataggccat aagcttaagg gaacagagac ctatatatcc cgagatatgc 11100 agttcatgag caaaacaatc cagcacaatg gagtgtacta tccagccagt atcaaaaaag 11160 tcctgagagt aggtccatgg ataaacacga tacttgatga ttttaaagtt agtttagaat 11220 ctataggcag cttaacacag gagttagaat aagcttatta acagaggaga tgcagtttaa 11280 catttggtta tatttaggaa ttgctttgca tacaatcaaa actccgaaat catgcattat 11340 gctatattta gtaacaataa gatatattga aagtattaaa acttttttta acacttaaaa 11400 atcttgatag cattgatatg gctttatcat tgtatatgaa tttgcctatg ctgtttggtg 11460 gtggtgatcc taatttgtta tatcgaagct tttataggag aactccagac ttccttacag 11520 aagctatagt acattcagtg tttgtgttga gctattatac tggtcacgat ttacaag 11580 ata agctccagga tcttccagat gatagactga acaaattctt gacatgtgtc atcacatttg 11640 ataaaaatcc caatgccgag tttgtaacat tgatgaggga tccacaggct ttagggtctg 11700 aaaggcaagc taaaattact agtgagatta atagattagc agtaacagaa gtcttaagta 11760 tagccccaaa caaaatattt tctaaaagtg cacaacatta tactaccact gagattgatc 11820 taaatgacat tatgcaaaat atagaaccaa cttaccctca tggattaaga gttgtttatg 11880 tttttataaa aaagtttacc gcagaaaaaa tagttaatct acaaaatcca tatatcagga 11940 taactaatat acttgaaaaa acatcagcaa tagatacaac tgatattaat agggctactg 12000 atatgatgag gaaaaatata actttactta taaggatact tccactagat tgtaacaaag 12060 acaaaagaga gttattaagt ttagaaaatc ttagtataac tgaattaagc aagtatgtaa 12120 gagaaagatc ttggtcatta tccaatatag taggagtaac atcgccaagt attatgttca 12180 taaatataca caatggacat actagcacta tagccagtgg gaaaaatata tataataata 12240 atgttaatag tttaactcgt ggtgaaagag gacccaccaa ggctcatcca gccatgggta 12300 cgcaggagaa aaaaacaatg ccagtgtaca acagacaagt tttaaccaaa aagcaaagag 12360 accaaataga tttattagca aaattagact gggtatatgc atccatagac aacaaagatg 12420 aattcatgga agaactgagt actggaacac ttggactgtc atatgaaaaa gccaaaaagt 12480 tgtttccaca atatctaagt gtcaattatt tacaccgttt aacagtcagt agtagaccat 12540 tgcatcaata gtgaattccc gaacaacaaa ccagcttata ttatcatttt gatactagtc 12600 tgtattaaca ctatcaatca gaaaagtatg gagatgaaga tatcgacatt gtgtttcaaa 12660 attgcataag ttttggtctt agcctgatgt cggttgtgga acaattcaca aacatatgtc 12720 tattctcata ctaatagaat ccgaagctga atgagataca tttgatgaaa cctcctatat 12780 ttacaggaga tgttgatatc atcaagttga agcaagtgat acaaaagcag cacatgttcc 12840 taccagataa aataagttta acccaatatg tagaattatt cttaagtaac aaagcactta 12900 aatctggatc tcacatcaac tctaatttaa tattagtaca taaaatgtct gattattttc 12960 ataatgctta tattttaagt actaatttag ctggacattg gattctgatt attcaactta 13020 tgaaagattc aaaaggtatt tttgaaaaag ggggtacata attggggaga actgatcata 13080 tgttcattaa tttgaatgtt ttctttaatg cttataagac tgttttcata ttatttgcta 13140 aaggttatgg taaagcaaaa ttagaatgtg atatgaacac ttcagatctt ctttgtgttt 13200 tggagttaat agacagtagc tactggaaat ctatgtctaa agt tttccta gaacaaaaag 13260 tcataaaata catagtcaat caagacacaa gtttgcgtag aataaaaggc tgtcacagtt 13320 ttaagttgtg gtttttaaaa cgccttaata atgctaaatt taccgtatgc ccttgggttg 13380 ttatcaccca ttaacataga aagctatatt acacacatga gatttagtta atcttacata 13440 aataaatgta gaatggggtt gataaattaa ccattaaaaa taaaaacaaa ttcaatgatg 13500 aattttacac atcaaatctc ttttacatta gttataactt ttcagacaac actcatttgc 13560 taacaaaaca aataagaatt gctaattcag aattagaaga taattataac aaactatatc 13620 acccaacccc agaaacttta gaaaatatgt cattaattcc tgttaaaagt aataatagta 13680 attttgtata acaaacctaa agtggaaata gatgatgtca ccgaatctat acattctcta 13740 gtaaaatgca tattaaatct tccactgtta ccacaagatt caattatagc aaacaagact 13800 tgtacaattt atttccaatt gttgtgatag acaagattat agatcattca ggtaatacag 13860 caaaatctaa ccaactttac accaccactt cacatcagac atctttagta aggaatagtg 13920 catcacttta ttgcatgctt ccttggcatc atgtcaatag atttaacttt gtatttagtt 13980 caagatcagt ccacaggatg atagagtata ttttaaaaga aaggacccca tcttaagatt 14040 gttgtatagc attcataggt gaaggagctg gtaact tatt attacgtacg gtagtagaac 14100 ttcatccaga cataagatac atttacagaa gtttaaaaga ttgcaatgat catagtttac 14160 ctattgaatt tctaaggtta tacaacgggc atataaacat agattatggt gagaatttaa 14220 tacagatgca ccattcctgc actaataaca ttcattggtc ttatttacat ataaaatttg 14280 cagaacctat tagcatcttt gtctgcgatg ctgaattacc tgttacagcc aattggagta 14340 aaattataat tgaatggagt aagcatgtaa gaaagtgcaa gtactgttct tctgtaaata 14400 gatgcatttt aattgcaaaa tatcatgctc aagatgacat ttagataaca tgatttcaaa 14460 ttactatatt aaaaacttac gtgtgcctag gtagcaagtt aaaaggatct gaagtttact 14520 taatccttac aataggccct gcaaatatac ttcctgtttt tgatgttgta caaaatgcta 14580 aattgacact ttcaagaact aaaaatttca ttatgcctaa aaaaactgac aaggaatcta 14640 tcgatgcaaa tattaaaagc ttaatacctt tcctttgtta ccctataaca aaaaaaggaa 14700 ttaagacttc attgtcaaaa ttgaagagtg tagttaatgg agatatatta tcatattcta 14760 taatgaagta tagctggacg ttcagcaaca agcttataaa ccacaagcat atgaatatcc 14820 taaaatggct agatcatgtt ttaaatttta gatcagctga acttaactac aatcatttat 14880 acatgataga gtccacatat ccttacttaa gtgaattgtt aaatagttta acaaccaatg 14940 gctgattaaa agctcaagaa ataacaggta gtgtgctata caaccttccc aacgaacagt 15000 atcattaaca agtttaaaat agtttggtca aatttagatg ctaacacatc attatattat 15060 aaatatacaa agttattaaa acttttcaat aatttagcat attgattcca aaattatcat 15120 aggggttaaa tttagtctta taaaagtcta aaactaacaa gcattcacaa ttatacatgt 15180 cacaacgaga cattagtttt tgacactttt tttctcgt. 15218 < 210 > 10 < 211 > 15229 < 212 > DNA < 213 > human re-spiratory syncytial virus < 400 > 10 atgcgtacta acgcgaaaaa cattcggaaa caaacttgca aaatggggca aataagaatt 60 tgataagtgc tatttaaatc taaccttttc aatcagaaat ggggtgcaat tcactgagca 120 tgataaaggt tagattacaa aatttatttg acaatgacga agtagcattg ttaaaaataa 180 tgacaaatta catgttatac attcttctga agccaaagca ccaatgcatt gtaatacata 240 aaacggcata caattaaatt gtttttatac atgttataac aagcagtgaa gtgtgccctg 300 acaacaatat tgtagtgaaa tctaacttta caacaatgcc aatattacaa aacggaggat 360 acatatggga attgattgag ttgacacact gctctcaatc atggatgata aaatggtcta 420 attgtgaaat caaattttct aaaagactaa gtgactcagt aatgactaat tatatgaatc 480 aaatatctga tttacttggg cttgatctca attcatgaat tatgtttagt ctaatttaat 540 agacatgtgt ttatcaccat tttagttaat ataaaacctc atcaaaggga aatggggcaa 600 ataaactcac ctaatcagtc aaaccatgag cactacaaat gacaacacta ctatgcaaag 660 acagacatga attgatgatc gacccctgtc gatggaatca ataataacat ctctcaccaa 720 agaaatcata acacacaaat tcatatactt gataaacaat gaatgtattg taagaaaact 780 tgatgaaaga caagctacat ttacattctt agtcaattat gagatgaagc tattgcacaa 840 agtagggagt accaaat aca agaaatacac tgaatataat acaaaatatg gcactttccc 900 catgcctata tttatcaatc atgacgggtt tctagaatgt attggcatta agcctacaaa 960 ataatataca acacactcct aatatgacct caacccgtaa attccaacaa aaaactaacc 1020 catccaaact aagctattcc tcaaacaaca gtgctcaaca agctaatcca gttaagaagg 1080 taaaaataaa ttttagtaat ataacataaa ggcagagcca ttggggcaaa tacaaagatg 1140 aagtcaagtt gctcttagca aaatgataca ttaaataagg atcagctgct gtcatccagc 1200 aaatacacta ttcaacgtag tacaggagat aatattgaca tgatgtgcaa ctcccaatta 1260 aaacacctaa acaaactatg tggtatgcta ttaatcactg aagatgcaaa tcataaattc 1320 acaggattaa taggtatgtt atatgctatg tccaggttag gaagggaaga cactataaag 1380 atacttaaag atgctggata tcatgttaaa gctaatggag tagatataac aacatatcgt 1440 caagatataa acggaaagga gaagtattaa aatgaaattc cattatcaag cttgacatca 1500 gaaatacaag tcaatattga gatagaatct agaaagtcct acaaaaaaat gctaaaagag 1560 atgggagaag tggctccaga atataggcat gattctccag actgtgggat gataatactg 1620 tgtatagctg cacttgtaat aaccaagtta gcagcaggag atagatcagg tcttacagca 1680 gggcaaacaa gtaattagga TGTC ttaaaa aacgctacaa aacgaaataa gggcctcata 1740 ccaaaggata tagctaacag tttttatgaa gtgtttgaaa aacaccctca tcttatagat 1800 gtttttgtgc actttggcat tgcacaatca tccacaagag ggggtagtag agttgaagga 1860 atctttgcag gattatttat gaatgcctat ggttcagggc aagtaatgct aagatgggga 1920 aatctgtaaa gttctagcca aaatatcatg ctaggacatg ctagtgtcca ggcagaaatg 1980 tggaagttta gaacaagttg tgagtatgca cagaagttgg gaggagaagc tggattctac 2040 catatattga acaatccaaa agcatcattg ctgtcattaa ctcaatttcc taacttctca 2100 agtgtggtcc taggcaatgc agcaggtcta ggcataatgg gagagtatag aggtacacca 2160 agaaaccaag atctatatga gcatatgcag tgcagccaaa agcaactcaa agaaaatgga 2220 gtaataaact acagtgtatt agacttaaca gcagaagaat tggaagccat aaagcatcaa 2280 aagaagatga ctcaacccca tgtagagctt taagttaaca aaaaatacgg ggcaaataag 2340 tcaacatgga gaagtttgca cctgaatttc atggagaaga tgcaaacaac aaagctacca 2400 aattcctaga atcaataaag ggcaagtttg catcatccaa agatcctaag aagaaagata 2460 gcataatatc tgttaactca atagatatag aagtaactaa agagagcccg ataacatctg 2520 gcaccaacat catcaatcca ataagtgaag ctgatagtac cccagaagct aaagccaact 2580 acccctagta acccaagaaa agcttcaaag aagatctcac cccaagtgac aacccctttt 2640 caaagaaaca ctaagttgta atagaaacat ttgataacaa tgaagaagaa tctagctact 2700 catatgaaga aataaatgat caaacaaatg acaacattac agcaagacta gatagaattg 2760 atgaaaaatt aagtgaaata ttaggaatgc tccatacatt agtagttgca agtgcaggac 2820 ccacctcagc tcgcgatgga ataagagatg ctatggttgg tctaagagaa gaaatgatag 2880 aaaaaa taag agcggaagca ttaatgacca atgataggtt agaggctatg gcaagactta 2940 aagcgaaaaa ggaatgagga atggcaaaag tgaagtgtct acacctcaga cttaatccaa 3000 cttccaaaaa attgagtaat ttgttggaag acaacgatag tgacaatgat ctatcacttg 3060 atgatttttg atcagtgatc aactcactca gcaatcaaca acatcaatga aacagacatc 3120 aatccattga atcaactgcc agactgaaca cacaaacgtc catcagcaga actaccaacc 3180 aatcaatcaa ccaattgatc aatcagcgac ctaacaaaat taacaatata gtaacaaaaa 3240 aagaacaaga tggggcaaat atggaaacat acgtgaacaa gcttcacgag ggctccacat 3300 acacagcagc tgttcagtac aatgttctag tgatcctgca aaaaagatga tcactaacaa 3360 tatgggtgcc tatgttccag tcatctgtgc cagcagactt gaacttgcaa gctcataaaa 3420 gcatcaacat actagtgaag cagatctcca accttcacta cgcccaaagg cgagtcacga 3480 ttaactcaag aagtgctgtg ctggcacaaa tgcctagtag ttttatcata agtgcaaatg 3540 tatcattaga tgaaagaagc aaattagcat atgatgtaac tacaccttgt gaaatcaaag 3600 aacatgctta catgcagtct aaagtaaaaa tacagtcaaa gtatgttaac gatcttacca 3660 tgaaaacatt caatcccact catgagatta ttgctctatg tgaatttgaa aatattatga 3720 catcaaaaag agtaat aata ccaacctatc taagatcaat tagtgtcaaa aacaaggacc 3780 tgaactcact agaaaatata gcaaccaccg aattcaaaaa tgctatcacc aatgcgaaaa 3840 tgcaggatta ttattcccta gtattagtta tcacagttac ggagcattca tgacaataaa 3900 aatatatcaa gccacagagt caatttatag tagatcttgg ggcctaccta gaaaaagaga 3960 tgtgactaca gcatatatta aattggaagc atacagctac acgtttttca atcaaaccac 4020 aacttaatta tagaggatta tcaacactaa atgacaggtc cacatatatc ttcaaactat 4080 acattatatc caaacatcat gagcatttac actacacact tttaccatat aaatcaatct 4140 catttaaaat ccaaaattac ttccagctat catctgttag acctagagtg cgaataggta 4200 aataaaacca aaatatgggg taaatagaca ttagttagag ttcaatcaat ctcaacaacc 4260 atttataccg ccaattcagt taaatctcaa acatatacta aatgggaaat acatccatca 4320 cacaagcaaa caatagaatt ttttggcctt attttacact aatacatatg atcttaactc 4380 taatctcttt actaattata atcactatta tgattgcaat actaaataag ctaagtgaac 4440 ataaaacatt ctgcaacaaa actcttgaac taggacagat gtatcaaatc aacacatagt 4500 gttctaccat tatgctgtgt caaattataa tcttgtatat ataaacaaac aaatccaatc 4560 ttctcacaga gtcatggtgg c gcaaaacca cgccaaccat catgatagca tagagtagtt 4620 atttaaaaat taacataatg atgaattatt ggtatgagat caggaacaac attggggcaa 4680 atgcagccat gtccaagcac aagaatcggc gcactgccgg gactctagaa aggacctggg 4740 atactcttaa tcatctaatt gtaatatcct cttgtttata cagattaaat ttaaaatcta 4800 tagcacaaat agcactgtca gttttggcaa tgataatctc aacctctctc ataattgcag 4860 ccataatatt catcatctct gccaatcaca aagttacact aacaacggtt acagttcaaa 4920 caataaaaaa ccacactgaa aaaaacatct ccacctacct tactcaagtc ccaccagaaa 4980 atccaaacaa gggtcaactc cccacaacca catcaccaat ccacacaaat tcagccacaa 5040 tacaaaatca tatcaccaaa atacaacagc gaaacacacc ggcagaatca acaaaccaaa 5100 ccacttcaac acagaccaac aagccaagca caaaatcacg ttcaaaaáat ccaccaaaaa 5160 aaccaaaaga tgattaccat tttgaagtgt tcaattttgt tccctgtagt atatgtggta 5220 ataatcaact ctgcaaatcc atctgcaaaa caataccaag caacaaacca aagaaaaaac 5280 acccacaaac caaccatcaa aaaccaacca ccaaaaccac aaacaaaaga gaccccaaaa 5340 caccagccaa aatgccaaaa tcaccaaccc aaagaaatca agcaaaaaaa ccaaccctca 5400 agaccacaga aagagacacc agcatttcac aatccaccgt atcactccaa gctcgacaca 5460 aatacacaat ccaacagcaa tccctccact caaccacctc cgaaaacaca cccagctcca 5520 cacaaatacc cacagcatcc gagccctcca cattaaatcc taattaaaaa acctagtcac 5580 atgcttagtt attcaaaaac tacatcttag cagagaaccg agcaagaaca tgatctatca 5640 aaattaaacc tggggcaaat aaccatggag ttgctgatcc acaggtcaag tgcaatcttc 5700 ctaactcttg ctgttaatgc attgtacctc acctcaagtc agaacataac tgaggagttt 5760 tacca atcga catgtagtgc agttagcaga ggttatttta gtgctttaag aacaggttgg 5820 tataccagtg tcataacaat agaattaagt aatataaaag aaaccaaatg caatggaact 5880 gacactaaag taaaacttat aaaacaagaa ttagataagt ataagaatgc agtaacagaa 5940 ttacagctac ttatgcaaaa cacgccagct gccaacaacc gggccagaag agaagcacca 6000 actacacaat cagtacatga caataccaca aaaaacctaa atgtatcaat aagcaagaaa 6060 aggaaacgaa gatttctggg cttcttgtta ggtgtaggat ctgcaatagc aagtggtata 6120 aagttttaca gctgtatcca ccttgaagga gaagtgaaca aaatcaaaaa tgctttgttg 6180 tctacaaaca aagctgtagt aatggggtca cagtctatca gtgttttaac cagcaaagtg 6240 ttagatctca agaattacat aaataaccga atattaccca tagtaaatca acagagctgt 6300 acattgaaac cgcatctcca ttccagcaga agttatagaa attgttggaa agaatagcag 6360 atcaccagag aatttagtgt taatgcaggt gtaacaacac ctttaagcac ttacatgtta 6420 acaaacagtg agttactatc attgatcaat gatatgccta taacaaatga ccagaaaaaa 6480 gcaatgttca ttaatgtcaa gatagtaagg caacaaagtt attctatcat gtctataata 6540 aaggaagaag tccttgcata tgttgtacag ctacctatct atggtgtaat agatacacct 6600 tgctggaaat tacacacatc acctctatgc accaccaaca tcaaagaagg atcaaatatt 6660 tgtttaacaa ggactgatag aggatggtat tgtgataatg caggatcagt atccttcttc 6720 ccacaggctg atacttgcaa agtacagtcc aatcgagtat tttgtgacac tatgaacagt 6780 ttaacattac caagtgaagt cagcctttgt aacactgaca tattcaattc caagtatgac 6840 tgacatcaaa tgcaaaatta aacagacata agcagctcag taattacttc tcttggagct 6900 atagtgtcat gctatggaaa aactaaatgc actgcatcca ataaaaatcg tgggattata 6960 aagacatttt ctaatggttg tgactatgtg tcaaacaaag gagtagatac tgtgtcagtg 7020 ggcaacactt tatactatgt aaacaagctg gaaggcaaaa acctttatgt aaaaggggaa 7080 attactatga cctataataa tcctctagtg tttccttctg tgcatcaata atgagtttga 7140 tctcaagtca atgaaaaaat caatcaaagt ttagctttta ttcgtagatc tgatgaatta 7200 ctacataatg taaatactgg caaatctact acaaatatta tgataactac aattattata 7260 gtaatcattg tagtattgtt atcattaata gctattggtt tactgttgta ttgcaaagcc 7320 aaaaacacac cagttacact aagcaaagac caactaagtg gaatcaataa tattgcattc 7380 caaaaaacta agcaaataga cttaatcatg tttcaacaac aatctgctga ccaccaatcc 7440 taacaa caaatcaact caaa tcatagcaca tatttcaaca tttcctcata ggctgaatca 7500 tcatgctacc tacacaacta agctagatct tcaactcata gttacataaa aaccccaagt 7560 atcacaatca aacactaaat cgacacatca ttcacaaaat taacaactgg ggcaaatatg 7620 atccttgtaa tcgcgaagaa atttgagatt agaggtcatt gcttgaatgg tagaagatgt 7680 cactacagtc ataattattt tgaatggcct cctcatgcat tactagtgag gcaaaacttc 7740 agatacttaa atgttaaaca gtcaatggac aaaagcatag acactttgtc ggaaataagt 7800 ggagctgctg aactggatag aacagaagaa tatgctcttg gtatagttgg agtgctagag 7860 gatcaataaa agttacatag caacataaca aaacaatcag catgtgttgc tatgagtaaa 7920 cttcttattg agatcaacag tgatgacatt aaaaaactga gagataacga agaacccaat 7980 taagagtgta tcgcctaaga caatactgtt atatcataca ttgagagcaa tagaaaaaac 8040 ccatccatct aacaagcaaa gctcaaaaga ctaccagcag gaagacaata acgtgctgaa 8100 tagatatcca aagaacacat caaaagcata accataagca actcaaaaga gtcaaccgtg 8160 aatgatcaaa atgaccaaac caaaaataat gatattaccg gataaatatc cttgtagtat 8220 atcatccata ttgatttcaa gtgaaagcat gattgctaca ttcaatcata aaaacatatt 8280 acaatttaac cataaccatt tggataacca ttaaatcata ccagtgttta tatttgatga 8340 acacctaaaa aattcattgg tgccactcaa acttattaga caatttctcc aacatcttaa 8400 gatatatata catccctgaa cagtatatat attagtgtca taatgcttga ccataacaat 8460 tttatatcat tcaaccataa aacaacctta ataaggttat gggacaaaat ggatcccatt 8520 actctgccaa attaatggaa tgtgtatcta actgatagtt atctaaaagg tgttatctct 8580 ttttcagaat gtaatgcttt agggagttac ctttttaacg gcccctatct taaaaatgat 8640 tacaccaact taattagtag acaaagccca ctactagagc atatgaatct aaaaaaacta 8700 actataacac agtcattaat atctagatat cataaaggtg aactgaagtt agaagaacca 8760 acttatttcc agtcattact tatgacatat aaaagtatgt cctcgtctga acaaattgct 8820 tacttaaaaa acaactaatt aataatacga agagctatag aaataagtga tgtaaaggtg 8880 tacgccatct tgaataaact gggactaaag gaaaaggaca gagttaagcc caacaataat 8940 tcaggtgatg aaaactcagt tcttacaacc ataatcaaag atgatatact ttcagctgtg 9000 gaaaacaatc aatcatatac aaattcagac aaaaatcatt cagtaaatca aaatatcact 9060 cactcttgaa atcaaaacaa aaaattgatg tgttcaatgc aacatcctcc atcatggtta 9120 tcaatttata atacactggt tacaaa atta aataacatat taacacaata tcgatcaaat 9180 gtcatgggtt gaggtaaaaa tatattaata gataatcaaa ctttaagtga ttttcagttt 9240 attttaaatc aatatggttg tatcgtttat cataaaggac tcaaaaaaat cacaactact 9300 acttacaatc aatttttgac atggaaagac atcagcctta tgtttgctta gcagattaaa 9360 taagtaattg attacttgga tttaaataca ttaaataaaa gagatgtgsa gcttagggct 9420 ttcaataatg ttgtgttatc acaactattt ctttatggag attgtatact gaaattattc 9480 cataatgaag gcttctacat aataaaagaa gtagagggat ttattatgtc tttaattcta 9540 aagaagatca aacataacag atttaggaaa cgattttata atagcatgct aaataacatc 9600 acagatgcag ctattaaggc tcaaaaaaac gagtatgtca ctactatcaa cactttatta 9660 gacaagacag tgtctgataa tatcataaat ggtaaatgga taatcctatt aagtaaattt 9720 cttaaattga ttaagcttgc aggtgataat aatctcaata acttgagtga gctttatttt 9780 tctttggaca ctcttcagaa gatgaaagac tccaatggtc tgctgtaaga aagcaatgga 9840 atgaaaccaa attaactgta gttctactta ttaagtaatc taagtacgtt aagaggtgct 9900 gaatcataaa ttcatttata ggggtttgta aatacctaca acagatggcc cactttaagg 9960 aatgctattg ttctacctct aagatggttg to actattata aacttaatac ttatccatct 10020 tcacagagaa ctacttgaaa agatttgatt attttatcag gattgcggtt ctatcgtgag 10080 tttcatctgc ctaaaaaagt ggatcttgaa atgataataa atgacaaagc catttcacct 10140 ccaaaagatt taatatggac tagttttcct agaaattaca tgccatcaca tatacaaaat 10200 tatatagaac atgaaaagtt gaagttctct gaaagtgaca gatcaagaag agtactagag 10260 gagataataa tattacttga attcaatgaa tgcgatctat acaattgtgt ggtcaatcaa 10320 acaactctaa agctatctca ccatgtggta tcactaactg gtaaagaaag agagctcagt 10380 gtaggtagaa tgtttgctat gcaaccaggt atgtttaggc aaattcaaat cttagcagag 10440 aaaatgatag ccgaaaatat tttacaattc ttccctgaga gtttgacaag atatggtgat 10500 ctagagcttc aaaagatatt agaattaaaa gcaggaataa gcaacaagtc aaatcgttat 10560 acaacaatta aatgataact tatcagtaaa tgttctatca ttacagacct tagcaaattc 10620 aatcaagcat ttagatatga aacatcatgt atctgcagtg atgtattaga tgaactgcat 10680 ggagtacaat ctctgttctc ttggttgcat ttaacaatac ctcttgtcac aataatatgt 10740 acatatagac atgcacctcc ttttataaag gatcatgttg ttaatcttaa taaagttgat 10800 gaacaaagtg gattatacag atatcatatg ggtggtattg aaggctggtg tcaaaaactg 10860 tggaccattg aagctatatc attattagat ctaatatctc tcaaagggaa attctctatc 10920 acagctctaa taaatggtga taatcagtca attgatataa tagacttata gtaaaccagt 10980 cccatgctca gagggtcaga agcagattat ttgttagcat taaatagcct taaattgcta 11040 tataaagagt atgcgggcat aggccacaag ctcaagggaa tatatcccga cagagaccta 11100 gatatgcaat tcatgagcaa aacaatccag cacaatggag tgtactatcc agccagtatc 11160 aaaaaagtcc tgagagtagg tccatggata aatacaatac ttgatgattt taaagttagt 11220 ttagaatcta taggtagctt aacacaggag ttagaatata gaggagagag cttattatgc 11280 agtttaatat ttaggaacat ttggttatac aatcaaattg ctttgcaact ccgaaatcat 11340 gcattatgtc acaataagct atatttagat atattgaaag tattaaaaca cttaaaaact 11400 ttttttaatc ttgatagtat tgatatggct ttaacattgt atatgaattt gcctatgctg 11460 tttggtggtg gtgatcctaa tttgttatat cgaagctttt ataggagaac tccagactt c 11520 cttacagaag ctatagtaca ttcagtgttt gtgttgagct attatactgg tcacgattta 11580 caagataagc tccaggatct tccagatgat agactgaaca aattcttgac atgtatcatc 11640 aaaatcccaa acgtttgata tgccgagttt gtaacattga tgagagatcc acaggcttta 11700 ggcaagcaaa gggtctgaaa aattactagt gagattaata gattagcagt gacagaagtc 11760 ttaagtatag ctccaaacaa aatattttct aaaagtgcac aacattatac taccactgag 11820 attgatctaa atgatattat gcaaaatata gaaccaactt accctcatgg attaagagtt 11880 gtttatgaaa gtttaccttt ttataaagca gaaaaaatag ttaatcttat atcaggaaca 11940 aaatccataa ctaatatact tgaaaaaaca tcagcaatag attcaactga tattaatagg 12000 tgatgaggaa gctactgata aaatataact ttacttataa ggatacttcc actagattgt 12060 aaagagagtt aacaaagaca attaagttta gaaaatctta gtataactga attaagcaag 12120 tatgtaagag aaagatcttg gtcgttatcc aatatagtag gagtaacatc gccaagtatt 12180 tggacattaa atgttcacaa atatacaact agcactatag ccagtggtat aattatagaa 12240 aaatataatg ttaatagttt aactcgtggt gaaagaggac ctactaagcc atgggtaggt 12300 tcatctacgc aggagaaaaa gtgtacaata aacaatgcca gacaagtttt to accaaaaag 12360 caaagagacc aaatagattt attagcaaaa ttagactggg tatatgcatc catagacaac 12420 aaagatgaat tcatggaaga actgagtact ggaacacttg gactgtcata tgagaaagcc 12480 aaaaaattgt ttccacaata tctaagtgtc aattatttac accgcttaac agtcagtagt 12540 agaccatgtg aattccctgc atcaatacca gcttatagaa caacaaatta tcatttcgat 12600 actagtccta tcaaccatgt attaacagaa aagtatggag atgaagatat cgacattgtg 12660 tttcaaaatt gcataagttt tggtcttagc ttaatgtcgg ttgtggaaca attcacaaac 12720 atatgtccta atagaattat tctcataccg aagctgaatg agatacattt gatgaaacct 12780 cctatattta caggagatgt tgatatcatc aagttgaagc aagtgataca aaaacagcac 12840 atgttcctac cagataaaat aagtttaacc caatatgtag aattattcct aagtaacaaa 12900 gcacttaaat ctggatctca catcaactct aatttaatat tagtacataa aatgtctgat 12960 tattttcata atgcttatat tttaagtact aatttagctg gacattggat tctgattatt 13020 aggattcaaa caacttatga aggtattttt gaaaaagatt ggggagaggg gtatataact 13080 gatcatatgt tcattaattt gaatgttttc tttaatgctt ataagactta tttgctatgt 13140 gttatggtaa tttcataaag agcaaaatta gaatgtgata tgaa cacttc agatcttctt 13200 tgtgttttgg agctaataga cagtagctac tggaaatcta tgtctaaagt tttcctagaa 13260 caaaaagtca taaaatacat aatcaatcaa gacacaagtt tgcatagaat aaaaggttgt 13320 catagtttta agttatggtt tttaaaacgc cttaataatg ctaaatttac cgtatgccct 13380 acatagatta tgggttgtta tcacccaaca cacatgaaag ctatattatc ttacatagat 13440 ttagttagaa tggggttaat aaatgtagat aaattaacca ttaaaaataa aaataaattc 13500 aatgatgaat tttacacatc aaatctcttt tacattagtt ataacttttc agataacact 13560 catttgctaa caaaacaaat aagaattgct aattcagaat tagaaaataa ttataacaaa 13620 ctatatcacc aactttagaa caaccccaga aatatgtcat taattcctgt caaaagtaat 13680 aatagtaata aacctaaatt tggtataagt ggaaataccg aatctatgat gacgtcaaca 13740 ttctccaata aaacgcatat taaatcttcc gctgttatta ttatagtaaa caagattcaa 13800 acaatttatt caagacttgt tccaattgtc gtgatagaca ggattataga tcattcaggt 13860 aatctaacca aatacagcaa actctacact accacttcac atcagacatc tttagtaagg 13920 aatagtgcat cactttattg catgcttcct tggcatcatg tcaatagatt taactttgta 13980 tttagttcca caggatgcaa gatcagtata gagtatattt taaaagatct taagattaaa 14040 gtatagcatt gaccccagtt ggagctggta cataggtgaa acgtacagta acttattatt 14100 gtagaacttc atccagacat aagatacatt tacagaagtt taaaagattg caatgatcat 14160 agtttaccta ttgaatttct aaggttatac aacgggcata taaacataga ttatggtgag 14220 aatttaacca ttcctgctac agatgcaact aataacattc attggtctta tttacatata 14280 aaatttgcag aacctattag catttttgtc tgcgatgctg aattacctgt tacagccaat 14340 ttataattga tggagtaaaa atggagtaag catgtaagaa agtgcaagta ctgttcctct 14400 gtaaatagat gcattttaat tgcaaaatat catgcccaag atgatattga tttcaaatta 14460 ctatattaaa gataacatta aacttacgtg tgcctaggta gcaagttaaa aggatctgaa 14520 gtttacttag tccttacaat aggccctgca aatatacttc ctgtttttaa tgttgtgcaa 14580 aatgctaaat tgattctttc aaggactaaa aatttcatta tgcctaaaaa aactgacaaa 14640 gaatctatcg atgcaaatat taaaagctta atacctttcc tttgttaccc tataacaaaa 14700 aaaggaatta agacttcatt gtcaaaattg aagagtgtag tatattatca ttagtggaga 14760 tattctatag ctggacgtaa tgaagtattc agcaacaagc ttataaacca caagcatatg 14820 aatggctaga aatatcctaa tcatgtttta aac tttagat cagctgaact taattacaat 14880 catttatata tgatagagtc cacatatcct tacttaagtg aattgttaaa cagtttaaca 14940 accaatgagc tcaagaagct gattaaaata acaggtagtg tactatacaa ccttcccaac 15000 gaacagtaac ttaaaacatc attaacaagt ttgatcaaat ttagatgcta acacatcata 15060 tattaaaaaa atattatagt tatatatgca aacttttcaa taatttagca tattgattcc 15120 aaagttatca ttttggtctt aaggggttga ataaaaatct aaaactaaca attatacatg tgcatttaca 15180 15229 acacaacgag acattagttt ttgacacttt ttttctcgt < 210 > 11 < 211 > 15219 < 212 > DNA < 213 > virus s i nc i t i al resp i ratori o humano < 400 > 11 acgggaaaaa aatgcgtact acaaacttgc acattcgaaa aaaatggggc aaataagaac 60 ttgataagtg ctatttaagt ctaacctttt caatcagaaa tggggtgcaa ttcactgagc 120 atgataaagg ttagattaca aaatttattt gacaatgacg aagtagcatt gttaaaaata 180 acatgttata ctgataaatt aattcttctg accaatgcat tagccaaagc agcaatacat 240 acaattaaat taaacggcat agtttttata catgttataa caagcagtga agtgtgccct 300 gataacaata ttgtagtgaa atctaacttt acaacaatgc caatactaca aaatggagga 360 tacatatggg aattgattga gttgacacac tgctctcaat taaacggttt aatggatgat 420 aattgtgaaa tcaaattttc taaaagacta agtgactcag taatgactaa ttatatgaat 480 caaatatctg acttacttgg gcttgatctc aattcatgaa ttatgtttag tctaattcaa 540 tagacatgtg tttattacca ttttagttaa tataaaaact catcaaaggg aaatggggca 600 cctaatcaat aataaactca caaaccatga gcactacaaa tgacaacact actatgcaaa 660 gattgatgat cacagacatg agacccctgt aataataaca caatggattc tctcttacca 720 aagaaatcat cacacacaaa ttcatatact tgataaacaa tgaatgtatt gtaagaaaac 780 ttgatgaaag acaagctaca tttacattct tagtcaatta tgagatgaag ctactgcaca 840 aagtagggag taccaaatac aaaaaataca ctgaatataa tacaaaatat ggcactttcc 900 ccatgcctat atttatcaat cacggcgggt ttctagaatg tattggcatt aagcctacaa 960 aacacactcc tataatatac aaatatgacc tcaacccgtg aattccaaca aaaaaaccaa 1020 ccaaactatt cccaaccaaa cctcaaacaa cagtgctcaa tagttaagaa ggagctaatc 1080 attaaaaata cattttagta aaagtaaagc aattggggca caataacata aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cattaaataa ggatcagctg ctgtcatcca 1200 gcaaatacac tattcaacgt agtacaggag ataatattga cactcccaat tatgatgtgc 1260 aaaaacacct aaacaaacta tgtggtatgc tattaatcac tgaagatgca aatcataaat 1320 tcacaggatt aataggtatg ttatatgcta tgtccaggtt aggaagggaa gacactataa 1380 agatgctgga agatacttaa tatcatgtta aagctaatgg agtagatata acaacatatc 1440 gtcaagatat aaatggaaag gaaatgaaat tcgaagtatt aacattatca agcttgacat 1500 cagaaataca agtcaatatt gagatagaat ctagaaagtc ctacaaaaaa atgctaaaag 1560 agtggctcca agatgggaga gaatataggc atgattctcc agactgtggg atgataatac 1620 tgtgtatag c tgcacttgtg ataaccaaat tagcagcagg agacagatca ggtcttacag 1680 cagtaattag gagggcaaac aatgtcttaa aaaacgaaat aaaacgatac aagggcctca 1740 taccaaagga tatagctaac agtttttatg aagtgtttga aaaacaccct catcttatag 1800 atgttttcgt gcactttggc attgcacaat catccacaag agggggtagt agagttgaag 1860 gaatctttgc aggattgttt atgaatgcct atggttcagg gcaagtaatg ctaagatggg 1920 caaatctgta gagttttagc tgctaggaca aaaaatatca tgctagtgtc caggcagaaa 1980 tggagcaagt tgtggaagtc tatgagtatg cacagaagtt gggaggagaa gctggattct 2040 accatatatt gaacaatcca aaagcatcat tgctgtcatt aactcaattt cccaacttct 2100 caagtgtggt cctaggcaat gcagcaggtc taggcataat gggagagtat agaggtacac 2160 caagaaacca ggatctttat gatgcagcta aagcatatgc agagcaactc aaagaaaatg 2220 ctacagtgta gagtaataaa ttagacttaa cagcagaaga attggaagcc ataaagcatc 2280 aactcaaccc caaagaagat gatgtagagc tttaagttaa caaaaaatac ggggcaaata 2340 agtcaacatg gagaagtttg cacctgaatt tcatggagaa gatgcaaata acaaagctac 2400 gaatcaataa caaattccta agggcaagtt cgcatcatcc aaagatccta agaagaaaga 2460 tagcataata GTCT ttaact caatagatat agaagtaact aaagagagcc cgataacatc 2520 tggcaccaac atcatcaatc caacaagtga agccgacagt accccagaaa caaaagccaa 2580 ctacccaaga aaacccctag taagcttcaa agaagatctc accccaagtg acaacccttt 2640 ttctaagttg tacaaggaaa caatagaaac atttgataac aatgaagaag aatctagcta 2700 ctcatatgaa gagataaatg atcaaacaaa tgacaacatt acagcaagac tagatagaat 2760 ttaagtgaaa tgatgaaaaa tattaggaat gctccataca ttagtagttg caagtgcagg 2820 acccacttca gctcgcgatg gaataagaga tgctatggtt ggtctaagag aagagatgat 2880 agaaaaaata agagcggaag cattaatgac caatgatagg ttagaggcta tggcaagact 2940 gaaagcgaaa taggaatgag aaatggcaaa agacacctca gatgaagtgt ctcttaatcc 3000 aacttccaaa aaattgagtg acttgttgga agacaacgat agtgacaatg atctatcact 3060 tgatcagcga tgatgatttt tcaactcact cagcaatcaa caacatcaat aaaacagaca 3120 tcaatccatt gaatcaactg ccagaccgaa caaacaaacg tccatcagta gaaccaccaa 3180 aaccaattga ccaatcaatc acccgacaaa tcaatcagca attaacaata tagtaacaaa 3240 gatggggcaa aaaagaacaa atatggaaac atacgtgaac aagcttcacg aaggctccac 3300 atacacagca gctgttcagt acaatgttct agaaaaagat gatgatcctg catcactaac 3360 aatatgggtg cctatgttcc agtcatctgt gccagcagac ttgctcataa aagaacttgc 3420 aagcatcaat atactagtga agcagatctc tacgcccaaa ggaccttcac tacgagtcac 3480 gattaactca agaagtgctg tgctggctca aatttcatca aatgcctagt taagcgcaaa 3540 tgtatcatta gatgaaagaa gcaaattagc atatgatgta actacacctt gtgaaatcaa 3600 agcatgcagt ctaacatgct taaaagtaaa aagtatgtta actacagtca aagatcttac 3660 catgaagaca ttcaacccca ctcatgagat cattgctcta tgtgaatttg aaaatattat 3720 agagtaataa gacatcaaaa taccaaccta tctaagatca attagtgtca agaacaagga 3780 ctagaaaata tctgaactca tagcaaccac cgaattcaaa aatgctatca ccaatgcaaa 3840 aattattcct tatgcaggat tagtgttagt tatcacagtt actgacaata aaggagcatt 3900 aaaccacaga caaatatatc gtcaatttat agtagatctt ggtgcctacc tagaaaaaga 3960 gagcatatat tatgtgacta ctaattggaa gcatacagct acacgttttt caatcaaacc 4020 actagaggat taaacttaat tatcaacact gaatgacagg tccacatata tcctcaaact 4080 acacactata tccaaacatc ataaacatct cttcatcaca acactacaca caaaccaatc 4140 tccaaaatca ccactcaaaa ctaccagcca ctatccgcta gacctagagt gcgaataggc 4200 aaataaaacc aaaatatggg gtaaatagac attagttaga gttcaatcaa tcttaacaac 4260 catttatacc gccaattcaa cacatatact ataaatctta aaatgggaaa tacatccatc 4320 acaatagaac tcacaagcaa attttggccc tattttacac taatacatat gatcttaact 4380 ctaatctttt tactaattat aatcactatc atgattgcaa gctaagtgaa cactaaataa 4440 tctgcaacaa cacaaagcat aactcttgaa ctaggacaga tgtaccaaat caacacacag 4500 agttcc acca ttatgctgtg tcaaaccata atcctgtata tacaaacaaa caaatccaat 4560 cctctcacag agtcacggtg tcgcaaaacc acgctaacca tcatggtagc atagagtagt 4620 tatttaaaaa ttaacataat gatgaattgt tagtatgaga tcaaaaacaa cattggggca 4680 aatgcaacca tgtccaaaca cgcactgcca caagaatcaa ggactctaga aaagacctgg 4740 gatactctta atcatctaat tgtaatatcc tcttgtttat acagattaaa tttaaaatct 4800 tagcactatc atagcacaaa agttttggca atgataatct cataattgca caacctctct 4860 gccataatat tcatcatctc tgccaatcac aaagttacac taacaacggt cacagttcaa 4920 acaataaaaa accacactga aaaaaacatc accacctacc ctactcaagt ctcaccagaa 4980 agggttagtt catccaagca acccacaacc acatcaccaa tccacacaag ttcagctaca 5040 acatcaccca atacaaaatc agaaacacac catacaacag cacaaaccaa aggcagaacc 5100 cacagaccaa accacttcaa acaaaaccac caagccaagc tccaccaaaa gtccaaaaaa 5160 aaagatgatt accattttga agtgttcaac ttcgttccct gcagtatatg tggcaacaat 5220 aatccatctg caactttgca caaaacaata ccaagcaaca aaccaaagaa gaaaccaacc 5280 caaacaaacc atcaaaccca accacaaaca aaccaccaaa aaagagaccc aaaaacacca 5340 gccaaaacga c gaaaaaaga aactaccacc aacccaacaa aaaaactaac cctcaagacc 5400 acagaaagag acaccagcac ctcacaatcc actgcactcg acacaaccac attaaaacac 5460 acagtccaac agcaatccct cctctcaacc acccccgaaa ctccacacaa acacacccaa 5520 acacccacag catccgagcc ctccacacca aactccaccc aaaaaaccca gccacatgct 5580 tagttattca aaaactacat cttagcagag aaccgtgatc tatcaagcaa gaacgaaatt 5640 caaataacca aaacctgggg tggagttgat gatccacaag tcaagtgcaa tcttcctaac 5700 tcttgctatt aatgcattgt acctcacctc aagtcagaac ataactgagg agttttacca 5760 atcgacatgt agtgcagtta gcagaggtta ttttagtgct ttaagaacag gttggtatac 5820 tagtgtcata acaatagaat taagtaatat aaaagaaacc aaatgcaatg gaactgacac 5880 taaagtaaaa cttatgaaac aagaattaga taagtataag aatgcagtaa cagaattaca 5940 gctacttatg caaaacacac cagctgtcaa caaccgggcc agaagagaag caccacagta 6000 acaatcaata tatgaactac cctaaatgta ccactaaaaa tcaataagca agaagaggaa 6060 acgaagattt ctaggcttct tgttaggtgt gggatctgca atagcaagtg gtatagctgt 6120 atcaaaagtt ctacaccttg aaggagaagt gaacaagatc aaaaatgctt tgttgtctac 6180 gtagtca aaacaaagct gtt tatcaaatgg ggtcagtgtt ttaaccagca aagtgttaga 6240 tctcaagaat tacataaata accaattatt acccatagta aatcaacaga gctgtcgcat 6300 gaaacagtta ctccaacatt tagaattcca gcagaagaac agcagattgt tggaaatcac 6360 agtgtcaatg cagagaattt caggtgtaac aacaccttta agcacttaca tgttgacaaa 6420 ctatcattaa cagtgagtta tcaatgatat gcctataaca aatgatcaga aaaaattaat 6480 gtcaagcaat gttcagatag taaggcaaca atcatgtcta aagttattcc taataaagga 6540 agaagtcctt gcatatgttg tacagctgcc tatctatggt gtaatagata caccttgctg 6600 gaaattgcac acatcgcctc tatgcactac caacatcaaa gaaggatcaa atatttgttt 6660 aacaaggact gatagaggat taatgcagga ggtattgtga tctttccaca tcagtatcct 6720 ggctgacact tgtaaagtac agtccaatcg agtattttgt gacactatga acagtttgac 6780 attaccaagt gaagtcagcc tttgtaacac tgacatattc aattccaagt atgactgcaa 6840 aattatgaca tcaaaaacag acataagcag ctcagtaatt acttctcttg gagctatagt 6900 ggtaaaacta gtcatgctat atccaacaaa aatgcactgc aatcgtggga ttataaagac 6960 attttctaat ggttgtgact atgtgtcaaa caaaggagta gatactgtgt cagtgggcaa 7020 cactttatac tatgtaaaca agctggaagg caagaacctt tatgtaaaag gggaacctat 7080 aataaattac tatgaccctc tagtgtttcc ttctgatgag tttgatgcat caatatctca 7140 agtcaatgaa aaaatcaatc aaagtttagc ttttattcgt agatctgatg aattactaca 7200 taatgtaaat actggcaaat ctactacaaa tattatgata actacaatta ttatagtaat 7260 cattgtagta ttgttatcat taatagctat tggtttactg ttgtattgta aagccaaaaa 7320 acactaagca cacaccagtt aagaccaact aagtggaatc aataatattg cattcagcaa 7380 aaccacctga atagacaaaa tcatgtttca acaacaatct gctgaccacc aatcccaaat 7440 caacttacaa caaatatttc aacatcacag tacaggctga atcatttcct cacatcatgc 7500 tacccacata actaagctag atccttaact tatagttaca taaaaacctc aagtatcaca 7560 atcaaccact aaatcaacac atcattcaca aaattaacag ctggggcaaa tatgtcgcga 7620 agaaatcctt gtaaatttga gattagaggt cattgcttga atggtagaag atgtcactac 7680 agtcataatt actttgaatg gcctcctcat gcattactag tgaggcaaaa cttcatgtta 7740 aacaagatac tcaagtcaat ggacaaaagc atagacactt tgtctgaaat aagtggagct 7800 gctgaactgg atagaacaga agaatatgct cttggtatag ttggagtgct agagagttac 7860 taaacaacat ataggatcta aacaaa ACAA tcagcatgtg ttgctatgag taaacttctt 7920 atagtgatga attgagatca cattaaaaag cttagagata atgaagaacc caattcacct 7980 aagataagag tgtacaatac tgttatatca tacattgaga gcaatagaaa aaacaacaag 8040 atctgctcaa caaaccatcc gagactacca gcagacgtgc tgaagaagac aataaagaac 8100 acattagata tccacaaaag cataaccata agcaatccaa aagagtcaac tgtgaatgat 8160 caaaatgacc aaaccaaaaa taatgatatt accggataaa tatccttgta gtatatcatc 8220 catattgatc tcaagtgaaa gcatggttgc tacattcaat cataaaaaca tattacaatt 8280 taaccataac tatttggata accaccagcg tttattaaat catatatttg atgaaattca 8340 ttggacacct aaaaacttat tagatgccac tcaacaattt ctccaacatc ttaacatccc 8400 tgaagatata tatacagtat atatattagt gtcataatgc ttgaccataa cgactctatg 8460 tcatccaacc ataaaactat tttgataagg ttatgggaca aaatggatcc cattattaat 8520 ggaaactctg ctaatgtgta tctaactgat agttatttaa aaggtgttat ctctttttca 8580 gagtgtaatg ctttagggag ttatcttttt aacggccctt atcttaaaaa tgattacacc 8640 gtagacaaag aacttaatta gagcatatga cccactacta actaactata atcttaaaaa 8700 acacagtcat taatatctag atatcataaa g gtgaactga aattagaaga accaacttat 8760 ttccagtcat tacttatgac atataaaagt atgtcctcgt ctgaacaaat tgctacaact 8820 aacttactta aaaaaataat acgaagagcc atagaaataa gtgatgtaaa ggtgtacgcc 8880 atcttgaata aactaggatt aaaggaaaag gacagagtta agcccaacaa taattcaggt 8940 gatgaaaact cagtacttac aaccataatt aaagatgata tactttcggc tgtggaaaac 9000 aatcaatcat atacaaattc agacaaaagt cactcagtaa atcaaaatat cactatcaaa 9060 acaacactct tgaaaaaatt gatgtgttca atgcaacatc ctccatcatg gttaatacac 9120 tggttcaatt tatatacaaa attaaataac atattaacac aatatcgatc aaatgaggta 9180 aaaagtcatg ggtttatatt aatagataat gtggttttca caaactttaa gtttatttta 9240 aatcaatatg gttgtatcgt ttatcataaa ggactcaaaa aaatcacaac tactacttac 9300 aatcaatttt tgacatggaa agacatcagc cttagcagat taaatgtttg cttaattact 9360 attgtttaaa tggataagta tacattaaac aaaagcttag ggctgagatg tggattcaat 9420 aatgttgtgt tatcacaatt atttctttat ggagattgta tactgaaatt atttcataat 9480 gaaggcttct acataataaa agaagtagag ggatttatta tgtctttaat tctaaacata 9540 atcaatttaa acagaagaag gaaacgattt tataatagca tgctaaataa catcacagat 9600 aggctcaaaa gcagctatta ggacctacta tcaagagtat gtcacacttt attagacaag 9660 acagtgtctg ataatatcat aaatggtaaa tggataatcc tattaagtaa atttcttaaa 9720 ttgcaggtga ttgattaagc taataatctc aataacttga gtgagctata ttttctcttc 9780 agaatctttg gacatccaat ggtcgatgaa agacaagcaa tggattctgt aagaattaac 9840 tgtaatgaaa ctaggttcta cttattaagt agtctaagta cattaagagg tgctttcatt 9900 tatagaatca taaaagggtt tgtaaatacc tacaacagat ggcccacctt aaggaatgct 9960 attgtcctac ctctaagatg gttaaactac tataaactta atacttatcc atctctactt 10020 gaaatcacag aaaatgattt gattatttta tcaggattgc ggttctatcg tgagtttcat 10080 aagtggatct ctgcctaaaa tgaaatgata ataaatgaca aagccatttc acctccaaaa 10140 gatctaatat ggactagttt tcctagaaat tacatgccat cacatataca aaattatata 10200 gaacatgaaa agttgaagtt ctctgaaagc gacagatcga gaagagtact agagtattac 10260 t tgagagata ataaattcaa tgaatgcgat ctatacaatt gtgtagtcaa tcaaagctat 10320 ctcaacaact ctaatcacgt ggtatcacta actggtaaag aaagagagct cagtgtaggt 10380 agaatgtttg ctatgcaacc aggtatgttt aggcaaatcc aaatcttagc agagaaaatg 10440 atattttaca atagctgaaa attcttccct gagagtttga caagatatgg tgatctagag 10500 tattagaatt cttcaaaaga aaaagcagga ataagcaaca agtcaaatcg ttataatgat 10560 aactacaaca attatatcag taaatgttct atcattacag atcttagcaa attcaatcag 10620 gcatttagat atgaaacatc atgtatctgc agtgatgtat tagatgaact gcatggagta 10680 caatctctgt tctcttggtt gcatttaaca atacctcttg tcacaataat atgtacatat 10740 agacatgcac ctcctttcat aaaggatcat gttgttaatc ttaatgaggt tgatgaacaa 10800 agtggattat acagatatca tatgggtggt attgagggct ggtgtcaaaa actgtggacc 10860 attgaagcta tatcattatt agatctaata tctctcaaag ggaaattctc tatcacagct 10920 ctgataaatg gtgataatca gtcaattgat ataagcaaac cagttagact tatagagggt 10980 ca'caagcaga cagacccatg gcattaaata ttatttgtta gttatataaa gccttaaatt 11040 gagtatgcag gtataggcca taagcttaag ggaacagaga cctatatatc ccgagatat g 11100 cagttcatga gcaaaacaat ccagcacaat ggagtgtact atccagccag tatcaaaaaa 11160 gtcctgagag taggtccatg gataaasacg atacttgatg attttaaagt tagtttagaa 11220 gcttaacaca tctataggca ggagttagaa tacagaggag aaagcttatt atgcagttta 11280 acatttggtt atatttagga atacaatcaa attgctttgc tcatgcatta aactccgaaa 11340 tgtaacaata agctatattt agatatattg aaagtattaa aacacttaaa aacttttttt 11400 aatcttgata gcattgatat ggctttatca ttgtatatga atttgcctat gctgtttggt 11460 ggtggtgatc ctaatttgtt atatcgaagc ttttatagga gaactccaga cttccttaca 11520 gaagctatag tacattcagt gtttgtgttg agctattata ctggtcacga tttacaagat 11580 aagctccagg atcttccaga tgatagactg aacaaattct tgacatgtgt catcacattt 11640 ccaatgccga gataaaaatc gtttgtaaca ttgatgaggg atccacaggc tttagggtct 11700 gaaaggcaag ctaaaattac tagtgagatt aatagattag cagtaacaga agtcttaagt 11760 atagccccaa acaaaatatt ttctaaaagt gcacaacatt atactaccac tgagattgat 11820 ttatgcaaaa ctaaatgaca tatagaacca acttaccctc atggattaag agttgtttat 11880 gaaagtttac ctttttataa agcagaaaaa ttatatcagg to atagttaatc acaaaatcc 11940 tacttgaaaa ataactaata aacatcagca atagatacaa ctgatattaa tagggctact 12000 gatatgatga ggaaaaatat aactttactt ataaggatac ttccactaga ttgtaacaaa 12060 gacaaaagag agttattaag tttagaaaat cttagtataa ctgaattaag caagtatgta 12120 agagaaagat cttggtcatt atccaatata gtaggagtaa catcgccaag tattatgttc 12180 acaatgaaca ttaaatatac aactagcact atagccagtg gtataataat agaaaaatat 12240 gtttaactcg aatgttaata tggtgaaaga ggacccacca agccatgggt aggctcatcc 12300 acgcaggaga aaaaaacaat gccagtgtac aacagacaag ttttaaccaa aaagcaaaga 12360 gaccaaatag atttattagc aaaattagac tgggtatatg catccataga caacaaagat 12420 gaattcatgg aagaactgag tactggaaca cttggactgt catatgaaaa agccaaaaag 12480 ttgtttccac aatatctaag tgtcaattat ttacaccgtt taacagtcag tagtagacca 12540 tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcattt tgatactagt 12600 cctatcaatc atgtattaac agaaaagtat ggagatgaag atatcgacat tgtgtttcaa 12660 aattgcataa gttttggtct tagcctgatg tcggttgtgg aacaattcac aaacatatgt 12720 cctaatagaa ttattctcat accgaagctg aatgagatac atttgatgaa acctcctata 12780 tttacaggag atgttgatat catcaagttg tacaaaagca aagcaagtga gcacatgttc 12840 ctaccagata aaataagttt aacccaatat gtagaattat tcttaagtaa caaagcactt 12900 aaatctggat ctcacatcaa ctctaattta atattagtac ataaaatgtc tgattatttt 12960 cataatgctt atattttaag tactaattta gctggacatt ggattctgat tattcaactt 13020 atgaaagatt caaaaggtat ttttgaaaaa gattggggag aggggtacat aactgatcat 13080 atgttcatta atttgaatgt tttctttaat gcttataaga cttatttgct atgttttcat 13140 aaaggttatg gtaaagcaaa attagaatgt gatatgaaca cttcagatct tctttgtgtt 13200 tagacagtag ttggagttaa ctactggaaa tctatgtcta aagttttcct agaacaaaaa 13260 acatagtcaa gtcataaaat tcaagacaca agtttgcgta gaataaaagg ctgtcacagt 13320 tttaagttgt ggtttttaaa acgccttaat aatgctaaat ttaccgtatg cccttgggtt 13380 gttaacatag attatcaccc aacacacatg aaagctatat tatcttacat agatttagtt 13440 agaatggsgc taataaatgt agataaatta accattaaaa ataaaaacaa attcaatgat 13500 gaattttaca catcaaatct cttttacatt agttataact tttcagacaa cactcatttg 13560 ctaacaaaac aaataagaat tgctaattca gaattagaag ata attataa caaactatat 13620 cacccaaccc cagaaacttt agaaaatatg tcattaattc ctgttaaaag taataatagt 13680 aacaaaccta aattttgtat aagtggaaat accgaatcta tgatgatgtc aacattctct 13740 agtaaaatgc atattaaatc ttccactgtt accacaagat tcaattatag caaacaagac 13800 ttgtacaatt tatttccaat gacaagatta tgttgtgata aggtaataca tagatcattc 13860 accaacttta gcaaaatcta caccaccact tcacatcaga catctttagt aaggaatagt 13920 gcatcacttt attgcatgct tccttggcat catgtcaata gatttaactt tgtatttagt 13980 tccacaggat gcaagatcag tatagagtat attttaaaag atcttaagat taaggacccc 14040 agttgtatag cattcatagg tgaaggagct ggtaacttat tattacgtac ggtagtagaa 14100 acataagata cttcatccag agtttaaaag catttacaga tcatagttta attgcaatga 14160 cctattgaat ttctaaggtt atacaacggg catataaaca tagattatgg tgagaattta 14220 accattcctg ctacagatgc aactaataac attcattggt cttatttaca tataaaattt 14280 gcagaaccta ttagcatctt tgtctgcgat gctgaattac ctgttacagc caattggagt 14340 aaaattataa ttgaatggag taagcatgta agaaagtgca agtactgttc ttctgtaaat 14400 agatgcattt taattgcaaa atatcatgct caagat gaca ttgatttcaa attagataac 14460 taaaaactta attactatat cgtgtgccta ggtagcaagt taaaaggatc tgaagtttac 14520 ttaatcctta caataggccc tgcaaatata cttcctgttt ttgatgttgt acaaaatgct 14580 aaattgatac tttcaagaac taaaaatttc attatgccta aaaaaactga caaggaatct 14640 atcgatgcaa atattaaaag cttaatacct ttcctttgtt accctataac aaaaaaagga 14700 attaagactt cattgtcaaa attgaagagt gtagttaatg gagatatatt atcatattct 14760 atagctggac gtaatgaagt attcagcaac aagcttataa accacaagca tatgaatatc 14820 ctaaaatggc tagatcatgt tttaaatttt agatcagctg aacttaatta caatcattta 14880 tacatgatag agtccacata tccttactta agtgaattgt taaatagttt aacaaccaat 14940 agctgattaa gagctcaaga aataacaggt agtgtgctat acaaccttcc caacgaacag 15000 tagtttaaaa tatcattaac aagtttggtc aaatttagat gctaacacat cattatatta 15060 agaatataca tagttattaa aacttttcaa taatttagca tattgattcc aaaattatca 15120 aaggggttaa ttttagtctt ataaaagtct aaaactaaca tgcattcaca attatacatg 15180 acacaacgag acattagttt ttgacacttt ttttctcgt 15219 < 210 > 12 < 211 > 15219 < 212 > ADJUST < 213 > vi rus s i nc i t i to the human sp e ct i t < 400 > 12 acgggaaaaa aatgcgtact acaaacttgc acattcgaaa aaaatggggc aaataagaac 60 ttgataagtg ctatttaagt ctaacctttt caatcagaaa tggggtgcaa ttcactgagc 120 atgataaagg ttagattaca aaatttattt gacaatgacg aagtagcatt gttaaaaata 180 acatgttata ctgataaatt aattcttctg accaatgcat tagccaaagc agcaatacat 240 acaattaaat taaacggcat agtttttata catgttataa caagcagtga agtgtgccct 300 gataacaata ttgtagtgaa atctaacttt acaacaatgc caatactaca aaatggagga 360 tacatatggg aattgattga gttgacacac tgctctcaat taaacggttt aatggatgat 420 aattgtgaaa tcaaattttc taaaagacta agtgactcag taatgactaa ttatatgaat 480 caaatatctg acttacttgg gcttgatctc aattcatgaa ttatgtttag tctaattcaa 54O tagacatgtg tttattacca ttttagttaa tataaaaact catcaaaggg aaatggggca 600 cctaatcaat aataaactca caaaccatga gcactacaaa tgacaacact actatgcaaa 660 gattgatgat cacagacatg agacccctgt aataataaca caatggattc tctcttacca 720 aagaaatcat cacacacaaa ttcatatact tgataaacaa tgaatgtatt gtaagaaaac 780 ttgatgaaag acaagctaca tttacactct tagtcaatta tgagatgaag ctactgcaca 840 aagtagggag taccaa atac aaaaaataca ctgaatataa tacaaaatat ggcactttcc 900 ccatgcctat atttatcaat cacggcgggt ttctagaatg tattggcatt aagcctac.aa 960 aacacactcc tataatatac aaatatgacc tcaacccgtg aattccaaca aaaaaaccaa 1020 ccaaactatt cccaaccaaa cctcaaacaa cagtgctcaa tagttaagaa ggagctaatc 1080 attaaaaata cattttagta aaagtaaagc aattggggca caataacata aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cattaaataa ggatcagctg ctgtcatcca 1200 gcaaatacac tattcaacgt agtacaggag ataatattga cactcccaat tatgatgtgc 1260 aaaaacacct aaacaaacta tgtggtatgc tattaatcac tgaagatgca aatcataaat 1320 tcacaggatt aataggtatg ttatatgcta tgtccaggtt aggaagggaa gacactataa 1380 agatgctgga agatacttaa tatcatgtta aagctaatgg agtagatata acaacatatc 1440 gtcaagatat aaatggaaag gaaatgaaat tcgaagtatt aacattatca agcttgacat 1500 cagaaataca agtcaatatt gagatagaat ctagaaagtc ctacaaaaaa atgctaaaag 1560 agtggctcca agatgggaga gaatataggc atgattctcc agactgtggg atgataatac 1620 tgtgtatagc tgcacttgtg ataaccaaat tagcagcagg agacagatca ggtcttacag 1680 cagtaattag gagggcaaac aa tgtcttaa aaaacgaaat aaaacgatac aagggcctca 1740 taccaaagga tatagctaac agtttttatg aagtgtttga aaaacaccct caccttatag 1800 atgttttcgt gcactttggc attgcacaat catccacaag agggggtagt agagttgaag 1860 gaatctttgc aggattgttt atgaatgcct atggttcagg gcaagtaatg ctaagatggg 1920 caaatctgta gagttttagc tgctaggaca aaaaatatca caggcagaaa tgctagtgtc 1980 tggagcaagt tgtggaagtc tatgagtatg cacagaagtt gggaggagaa gctggattct 2040 gaacaatcca accatatatt aaagcatcat tgctgtcatt aactcaattt cccaacttct 2100 caagtgtggt cctaggcaat gcagcaggtc taggcataat gggagagtat agaggtacac 2160 caagaaacca ggatctttat gatgcagcta aagcatatgc agagcaactc aaagaaaatg 2220 ctacagtgta gagtaataaa cagcagaaga ttagacttaa attggaagcc ataaagcatc 2280 aactcaaccc caaagaagat gatgtagagc tttaagttaa caaaaaatac ggggcaaata 2340 agtcaacatg gagaagtttg cacctgaatt tcatggagaa gatgcaaata acaaagctac 2400 caaattccta gaatcaataa agggcaagtt aaagatccta cgcatcatcc agaagaaaga 2460 tagcataata tctgttaact caatagatat agaagtaact aaagagagcc cgataacatc 2520 tggcaccaac atcatcaatc caacaagtga agccgacagt caaaagccaa accccagaaa 2580 ctacccaaga aaacccctag taagcttcaa agaagatctc accccaagtg acaacccttt 2640 ttctaagttg tacaaggaaa caatagaaac atttgataac aatgaagaag aatctagcta 2700 ctcatatgaa gagataaatg atcaaacaaa tgacaacatt acagcaagac tagatagaat 2760 ttaagtgaaa tgatgaaaaa tattaggaat gctccataca ttagtagttg caagtgcagg 2820 acccacttca gctcgcgatg gaataagaga tgctatggtt ggtctaagag aagagatgat 2880 agaaaaaata agagcggaag cattaatgac caatgatagg ttagaggcta tggcaagact 2940 gaaagcgaaa taggaatgag aaatggcaaa agacacctca gatgaagtgt ctcttaatcc 3000 aacttccaaa aaattgagtg acttgttgga agacaacgat agtgacaatg atctatcact 3060 tgatcagcga tgatgatttt tcaactcact cagcaatcaa caacatcaat aaaacagaca 3120 tcaatccatt gaatcaactg ccagaccgaa caaacaaacg tccatcagta gaaccaccaa 3180 aaccaattga ccaatcaatc acccgacaaa tcaatcagca tagtaacaaa attaacaata 3240 aaaagaacaa gatggggcaa atatggaaac atacgtgaac aagcttcacg aaggctccac 3300 atacacagca gctgttcagt acaatgttct agaaaaagat gatgatcctg catcactaac 3360 aatatgggtg cctatgttcc agtcatctgt gccagcagac ttgctcataa aagaacttgc 3420 aagcatcaat atactagtga agcagatctc tacgcccaaa ggaccttcac tacgagtcac 3480 gattaactca agaagtgctg tgctggctca aatttcatca aatgcctagt taagcgcaaa 3540 gatgaaagaa tgtatcatta gcaaattagc atatgatgta gtgaaatcaa actacacctt 3600 agcatgcagt ctaacatgct taaaagtaaa aagtatgtta actacagtca aagatcttac 3660 catgaagaca ttcaacccca ctcatgagat cattgctcta tgtgaatttg aaaatattat 3720 agagtaataa gacatcaaaa taccaaccta tctaagatca attagtgtca agaacaagga 3780 ctagaaaata tctgaactca tagcaaccac cgaattcaaa aatgctatca ccaatgcaaa 3840 aattattcct tatgcaggat tagtgttagt tatcacagtt actgacaata aaggagcatt 3900 aaaccacaga caaatatatc gtcaatttat agtagatctt ggtgcctacc tagaaaaaga 3960 gagcatatat tatgtgacta ctaattggaa gcatacagct acacgttttt caatcaaacc 4020 taaa actagaggat 'ttaat tatcaacact gaatgacagg tccacatata tcctcaaact 4080 acaca ctata tccaaacatc ataaacatct cttcatcaca acactacaca caaaccaatc 4140 tccaaaatca ccactcaaaa ctaccagcca ctatctgcta gacctagagt gcgaataggt 4200 aaataaaacc aaaatatggg gtaaatagac attagttaga gttcaatcaa tcttaacaac 4260 catttatacc gccaattcaa cacatatact ataaatctta aaatgggaaa tacatccatc 4320 acaatagaat tcacaagcaa attttggccc tattttacac taatacatat gatcttaact 4380 ctaatctttt tactaattat aatcactatt atgattgcaa tactaaataa gctaagtgaa 4440 cataaagcat tctgtaacaa aactcttgaa ctaggacaga tgtatcaaat caacacatag 4500 agttctacca ttatgctgtg atcctgtata tcaaattata tataaacaaa caaatccaat 4560 cttctcacag agtcatggtg tcgcaaaacc acgctaacta tcatggtagc atagagtagt 4620 tatttaaaaa ttaacataat gatgaattgt tagtatgaga tcaaaaacaa cattggggca 4680 tgtccaaaca aatgcaacca caagaatcaa cgcactgcca ggactctaga aaagacctgg 4740 gatactctta atcatctaat tgtaatatcc tcttgtttat acagattaaa tttaaaatct 4800 atagcacaaa tagcactatc atgataatct agttttggca caacctctct cataattgca 4860 gccataatat tcatcatctc tgccaatcac aaagttacac taacaacggt cacagttcaa 4920 acaataaaaa accacactga aaaaaacatc accacctacc ctactcaagt ctcaccagaa 4980 agggttagtt catccaagca acccacaacc acatcaccaa tccacacaag ttcagctaca 5040 acatcaccca atacaaaatc agaaacacac catacaacag cacaaaccaa aggcagaacc 5100 cacagaccaa accacttcaa acaaaaccac caagccaagc tccaccaaaa gtccaaaaaa 5160 aaagatgatt accattttga agtgttcaac ttcgttccct gcagtatatg tggcaacaat 5220 caactttgca aatccatctg caaaacaata ccaagcaaca aaccaaagaa gaaaccaacc 5280 atcaaaccca accacaaaca aaccaccaaa caaacaaacc aaaaacacca aaagagaccc 5340 cgaaaaaaga gccaaaacga aactaccacc aacccaacaa aaaaactaac cctcaagacc 5400 acagaaagag acaccagcac ctcacaatcc actgcactcg acacaaccac attaaaacac 5460 acagtccaac agcaatccct cctctcaacc acccccgaaa ctccacacaa acacacccaa 5520 acacccacag catccgagcc ctccacacca aactccaccc aaaaaaccca gccacatgct 5580 tagttattca aaaactacat cttagcagag aaccgtgatc tatcaagcaa gaacgaaatt 5640 caaataacca aaacctgggg tggagttgat gatccacaag tcaagtgcaa tcttcctaac 5700 tcttgctatt aatgcattgt acctcacctc aagtcagaac ataactgagg agttttacca 5760 atcgacatgt agtgcagtta gcagaggtta ttttagtgct ttaagaacag gttggtatac 5820 tagtgtcata acaatagaat taagtaatat aaaagaaacc aaatgcaatg gaactgacac 5880 taaagtaaaa cttatgaaac aagaattaga taagtataag aatgcagtaa cagaattaca 5940 gctacttatg caaaacacac cagctgtcaa caaccgggcc agaagagaag caccacagta 6000 acaatcaata tatgaactac cctaaatgta ccactaaaaa tcaataagca agaagaggaa 6060 acgaagattt ctaggcttct tgttaggtgt gggatctgca atagcaagtg gtatagctgt 6120 atcaaa AGTT ctacaccttg aaggagaagt gaacaagatc aaaaatgctt tgttgtctac 6180 aaacaaagct gtagtcagtt tatcaaatgg ggtcagtgtt ttaaccagca aagtgttaga 6240 tctcaagaat tacataaata accaattatt acccatagta aatcaacaga gctgtcgcat 6300 gaaacagtta ctccaacatt tagaattcca gcagaagaac agcagattgt tggaaatcac 6360 agtgtcaatg cagagaattt caggtgtaac aacaccttta agcacttaca tgttgacaaa 6420 ctatcattaa cagtgagtta tcaatgatat gcctataaca aatgatcaga aaaaattaat 6480 gtcaagcaat gttcagatag taaggcaaca atcatgtcta aagttattcc taataaagga 6540 agaagtcctt gcatatgttg tacagctgcc tatctatggt gtaatagata caccttgctg 6600 gaaattgcac acatcgcctc tatgcactac caacatcaaa gaaggatcaa atatttgttt 6660 aacaaggact gatagaggat taatgcagga ggtattgtga tctttccaca tcagtatcct 6720 ggctgacact tgtaaagtac agtccaatcg agtattttgt gacactatga acagtttgac 6780 attaccaagt gaagtcagcc tttgtaacac tgacatattc aattccaagt atgactgcaa 6840 aattatgaca tcaaaaacag acataagcag ctcagtaatt acttctcttg gagctatagt 6900 ggtaaaacta gtcatgctat atccaacaaa aatgcactgc aatcgtggga ttataaagac 6960 attttctaat g gttgtgact atgtgtcaaa gatactgtgt caaaggagta cagtgggcaa 7020 tatgtaaaca cactttatac agctggaagg caagaacctt tatgtaaaag gggaacctat 7080 aataaattac tatgaccctc tagtgtttcc ttctgatgag tttgatgcat caatatctca 7140 agtcaatgaa aaaatcaatc aaagtttagc ttttattcgt agatctgatg aattactaca 7200 taatgtaaat actggcaaat ctactacaaa tattatgata actacaatta ttatagtaat 7260 cattgtagta ttgttatcat taatagctat tggtttactg ttgtattgta aagccaaaaa 7320 acactaagca cacaccagtt aagaccaact aagtggaatc aataatattg cattcagcaa 7380 aaccacctga atagacaaaa tcatgtttca acaacaatct gctgaccacc aatcccaaat 7440 caacttacaa caaatatttc aacatcacag tacaggctga atcatttcct cacatcatgc 7500 tacccacata actaagctag atccttaact tatagttaca taaaaacctc aagtatcaca 7560 atcaaccact aaatcaacac atcattcaca aaattaacag ctggggcaaa tatgtcgcga 7620 agaaatcctt gtaaatttga gattagaggt cattgcttga atggtagaag atgtcactac 7680 agtcataatt actttgaatg gcctcctcat gcattactag tgaggcaaaa cttcatgtta 7740 aacaagatac tcaagtcaat ggacaaaagc atagacactt tgtctgaaat aagtggagct 7800 gctgaactgg atagaac aga agaatatgct cttggtatag ttggagtgct agagagttac 7860 ataggatcta taaacaacat aacaaaacaa tcagcatgtg ttgctatgag taaacttctt 7920 atagtgatga attgagatca cattaaaaag cttagagata atgaagaacc caattcacct 7980 aagataagag tgtacaatac tgttatatca tacattgaga gcaatagaaa aaacaacaag 8040 atctgctcaa caaaccatcc gagactacca gcagacgtgc tgaagaagac aataaagaac 8100 acattagata tccacaaaag cataaccata agcaatccaa aagagtcaac tgtgaatgat 8160 caaaatgacc aaaccaaaaa taatgatatt accggataaa tatccttgta gtatatcatc 8220 catattgatc tcaagtgaaa gcatggttgc tacattcaat cataaaaaca tattacaatt 8280 taaccataac tatttggata accaccagcg tttattaaat catatatttg atgaaattca 8340 ttggacacct aaaaacttat tagatgccac tcaacaattt ctccaacatc ttaacatccc 8400 tgaagatata tatacagtat atatattagt gtcataatgc ttgaccataa cgactctatg 8460 tcatccaacc ataaaactat tttgataagg ttatgggaca aaatggatcc cattattaat 8520 ggaaactctg ctaatgtgta tctaactgat agttatttaa aaggtgttat ctctttttca 8580 gagtgtaatg ctttagggag ttatcttttt aacggccctt atcttaaaaa tgattacacc 8640 aacttaatta gtagacaaag cccactacta atcttaaaaa gagcatatga actaactata 8700 acacagtcat taatatctag atatcataaa ggtgaactga aattagaaga accaacttat 8760 ttccagtcat tacttatgac atataaaagt atgtcctcgt ctgaacaaat tgctacaact 8820 aacttactta aaaaaataat acgaagagcc atagaaataa gtgatgtaaa ggtgtacgcc 8880 atcttgaata aactaggatt aaaggaaaag gacagagtta agcccaacaa taattcaggt 8940 gatgaaaact cagtacttac aactataatt aaagatgata tactttcggc tgtggaaaac 9000 aatcaatcat atacaaattc agacaaaagt cactcagtaa atcaaaatat cactatcaaa 9060 tgaaaaaatt acaacactct gatgtgttca atgcaacatc ctccatcatg gttaatacac 9120 tggttcaatt tatatacaaa attaaataac atattaacac aatatcgatc aaatgaggta 9180 aaaagtcatg ggtttatatt aatagataat gtggttttca caaactttaa gtttatttta 9240 aatcaatatg gttgtatcgt ttatcataaa ggactcaaaa aaatcacaac tactacttac 9300 aatcaatttt tgacatggaa agacatcagc cttagcagat taaatgtttg cttaattact 9360 attgtttaaa tggataagta tacattaaac aaaagcttag ggctgagatg tggattcaat 9420 aatgttgtgt tatcacaatt atttctttat ggagattgta tactgaaatt atttcataat 9480 gaaggcttct acataataaa agaagt agag ggatttatta tgtctttaat tctaaacata 9540 acagaagaag atcaatttag gaaacgattt tataatagca tgctaaataa catcacagat 9600 aggctcaaaa gcagctatta ggacctacta tcaagastat gtcacacttt attagacaag 9660 acagtgtctg ataatatcat aaatggtaaa tggataatcc tattaagtaa atttcttaaa 9720 ttgcaggtga ttgattaagc aataacttga taataatctc gtgagctata ttttctcttc 9780 agaatctttg gacatccaat ggtcgatgaa agacaagcaa tggattctgt aagaattaac 9840 ctaagttcta tgtaatgaaa cttattaagt agtctaagta cattaagagg tgctttcatt 9900 tatagaatca taaaagggtt tgtaaafacc tacaacagat ggcccacctt aaggaatgct 9960 attgtcctac ctctaagatg gttaaactac tataaactta atacttatcc atctctactt 10020 gaaatcacag aaaatgattt gattatttta tcaggattgc ggttctatcg tgagtttcat 10080 aagtggatct ctgcctaaaa tgaaatgata ataaatgaca aagccatttc acctccaaaa 10140 gatctaatat ggactagttt tcctagaaat tacatgccat cacatataca aaattatata 10200 gaacatgaaa agttgaagtt ctctgaaagc gacagatcga gaagagtact agagtattac 10260 ataaattcaa ttgagagata tgaatgcgat ctatacaatt gtgtagtcaa tcaaagctat 10320 ctcaacaact ctaatcacgt ggtatc minutes actggtaaag aaagagagct cagtgtaggt 10380 agaatgtttg ctatgcaacc aggtatgttt aggcaaatcc aaatcttagc agagaaaatg 10440 atattttaca atagctgaaa attcttccct gagagtttga caagatatgg tgatctagag 10500 tattagaatt cttcaaaaga aaaagcagga ataagcaaca agtcaaatcg ttataatgat 10560 aactacaaca attatatcag taaatgttct atcattacag atcttagcaa attcaatcag 10620 gcatttagat atgaaacatc atgtatctgc agtgatgtat tagatgaact gcatggagta 10680 caatctctgt tctcttggtt gcatttaaca atacctcttg tcacaataat atgtacatat 10740 agacatgcac ctcctttcat aaaggatcat gttgttaatc ttaatgaggt tgatgaacaa 10800 agtggattat acagatatca tatgggtggt attgagggct ggtgtcaaaa actgtggacc 10860 attgaagcta tatcattatt agatctaata tctctcaaag ggaaattctc tatcacagct 10920 ctgataaatg gtgataatca gtcaattgat ataagcaaac cagttagact tatagagggt 10980 cacaagcaga cagacccatg ttatttgtta gcattaaata gttatataaa gccttaaatt 11040 gagtatgcag gtataggcca taagcttaag ggaacagaga cctatatatc ccgagatatg 11100 cagttcatga gcaaaacaat ccagcacaat ggagtgtact atccagccag tatcaaaaaa 11160 gtcctgagag taggtccatg gataaacacg atacttgatg attttaaagt tagtttagaa 11220 gcttaacaca tctataggca ggagttagaa tacagaggag aaagcttatt atgcagttta 11280 acatttggtt atatttagga attgctttgc atacaatcaa tcatgcatta aactccgaaa 11340 tgtaacaata agctatattt agatatattg aaagtattaa aacacttaaa aacttttttt 11400 aatcttgata gcattgatat ggctttatca ttgtatatga atttgcctat gctgtttggt 11460 ggtggtgatc ctaatttgtt ttttatagga atatcgaagc cttccttaca gaactccaga 11520 gaagctatag tacattcagt gtttgtgttg agctattata ctggtcacga tttacaagat 11580 aagctccagg atcttccaga tgatagactg aacaaattct tgacatgtgt catcacattt 11640 ccaatgccga gataaaaatc gtttgtaaca ttgatgaggg atccacaggc tttagggtct 11700 gaaaggcaag ctaaaattac tagtgagatt aatagattag cagtaacaga agtcttaagt 11760 atagccccaa acaaaatatt ttctaaaagt gcacaacatt atactaccac tgagattgat 11820 ttatgcaaaa ctaaatgaca tatagaacca acttaccctc atggattaag agttgttta t 11880 gaaagtttac ctttttataa agcagaaaaa atagttaatc ttatatcagg aacaaaatcc 11940 tacttgaaaa ataactaata aacatcagca atagatacaa ctgatattaa tagggctact 12000 gatatgatga ggaaaaatat aactttactt ataaggatac ttgtaacaaa ttccactaga 12060 gacaaaagag agttattaag tttagaaaat cttagtataa ctgaattaag caagtatgta 12120 agagaaagat cttggtcatt atccaatata gtaggagtaa catcgccaag tattatgttc 12180 acaatggaca ttaaatatac aactagcact atagccagtg gtataataat agaaaaatat 12240 gtttaactcg aatgttaata tggtgaaaga ggacccacca agccatgggt aggctcatcc 12300 acgcaggaga aaaaaacaat gccagtgtac aacagacaag ttttaaccaa aaagcaaaga 12360 gaccaaatag atttattagc aaaattagac tgggtatatg catccataga caacaaagat 12420 gaattcatgg aagaactgag tactggaaca cttggactgt catatgaaaa agccaaaaag 12480 ttgtttccac aatatctaag tgtcaattat ttacaccgtt taacagtcag tagtagacca 12540 tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcattt tgatactagt 12600 cctatcaatc atgtattaac agaaaagtat ggagatgaag atatcgacat tgtgtttcaa 12660 aattgcataa gttttggtct tagcctgatg aacaattcac to tcggttgtgg aacatatgt 12720 cctaatagaa ttattctcat accgaagctg aatgagatac atttgatgaa acctcctata 12780 tttacaggag atgttgatat catcaagttg tacaaaagca aagcaagtga gcacatgttc 12840 ctaccagata aaataagttt aacccaatat gtagaattat tcttaagtaa caaagcactt 12900 aaatctggat ctcacatcaa ctctaattta atattagtac ataaaatgtc tgattatttt 12960 cataatgctt atattttaag tactaattta gctggacatt ggattctgat tattcaactt 13020 atgaaagatt caaaaggtat ttttgaaaaa gattggggag aggggtacat aactgatcat 13080 atgttcatta atttgaatgt tttctttaat gcttataaga cttatttgct atgttttcat 13140 aaaggttatg gtaaagcaaa attagaatgt gatatgaaca cttcagatct tctttgtgtt 13200 tagacagtag ttggagttaa ctactggaaa tctatgtcta aagttttcct agaacaaaaa 13260 acatagtcaa gtcataaaat tcaagacaca agtttgcgta gaataaaagg ctgtcacagt 13320 tttaagttgt ggtttttaaa acgccttaat aatgctaaat ttaccgtatg cccttgggtt 13380 gttaacatag attatcaccc aacacacatg aaagctatat tatcttacat agatttagtt 13440 agaatggggt taataaatgt agataaatta accattaaaa ataaaaacaa attcaatgat 13500 gaattttaca catcaaatct cttttacatt agttataact TTTC agacaa cactcatttg 13560 ctaacaaaac aaataagaat tgctaattca gaattagaag ataattataa caaactatat 13620 cacccaaccc cagaaacttt agaaaatatg tcattaattc ctgttaaaag taataatagt 13680 aacaaaccta aattttgtat aagtggaaat accgaatcta tgatgatgtc aacattctct 13740 agtaaaatgc atattaaatc ttccactgtt accacaagat tcaattatag caaacaagac 13800 ttgtacaatt tatttccaat gacaagatta tgttgtgata aggtaataca tagatcattc 13860 accaacttta gcaaaatcta caccaccact tcacatcaga catctttagt aaggaatagt 13920 gcatcacttt attgcatgct tccttggcat catgtcaata gatttaactt tgtatttagt 13980 tccacaggat gcaagatcag tatagagtat attttaaaag atcttaagat taaggacccc 14040 agttgtatag cattcatagg tgaaggagct ggtaacttat tattacgtac ggtagtagaa 14100 acataagata cttcatccag catttacaga agtttaaaag attgcaatga tcatagttta 14160 cctattgaat ttctaaggtt atacaacggg catataaaca tagattatgg tgagaattta 14220 accattcctg ctacagatgc aactaataac attcattggt cttatttaca tataaaattt 14280 gcagaaccta ttagcatctt tgtctgcgat gctgaattac ctgttacagc caattggagt 14340 aaaattataa ttgaatggag taagcatgta agaaagtgca agtactgttc ttctgtaaat 14400 agatgcattt taattgcaaa atatcatgct caagatgaca ttgatttcaa attagataac 14460 attactatat taaaaactta cgtgtgccta ggtagcaagt taaaaggatc tgaagtttac 14520 ttaatcctta caataggccc tgcaaatata cttcctgttt ttgatgttgt acaaaatgct 14580 aaattgatac tttcaagaac taaaaatttc aaaaaactga attatgccta caaggaatct 14640 atcgatgcag atattaaaag cttaatacct ttcctttgtt accctataac aaaaaaagga 14700 attaagactt cattgtcaaa attgaagagt gtagttaatg gagatatatt atcatattct 14760 atagctggac gtaatgaagt attcagcaac aagcttataa accacaagca tatgaatatc 14820 ctaaaatggc tagatcatgt tttaaatttt agatcagctg aacttaatta caatcattta 14880 tacatgatag agtccacata tccttactta agtgaattgt taaatagttt aacaaccaat 14940 agctgattaa gagctcaaga aataacaggt agtgtgctat acaaccttcc caacgaacag 15000 tagtttaaaa tatcattaac aagtttggtc aaatttagat gctaacacat cattatatta 15060 aaaatataca tagttattaa taatttagca aacttttcaa aaaattatca tattgattcc 15120 aaggggttaa ttttagr.ctt aaaactaaca ataaaagtct tgcattcaca attatacatg 15180 acacaacgag acattagttt ttgacacttt tt ttctcgt 15219 < 210 > 13 < 211 > 15219 < 212 > DNA < 213 > human respiratory syncytial virus < 400 > 13 acgggaaaaa aatgcgtact acaaacttgc acattcgaaa aaaatggggc aaataagaac 60 ttgataagtg ctatttaagt ctaacctttt caatcagaaa tggggtgcaa ttcactgagc 120 atgataaagg ttagattaca aaatttattt gacaatgacg aagtagcatt gttaaaaata 180 acatgttata ctgataaatt aattcttctg accaatgcat tagccaaagc agcaatacat 240 acaattaaat taaacggcat agtttttata catgttataa caagcagtga agtgtgccct 300 gataacaata ttgtagtgaa atctaacttt acaacaatgc caatactaca aaatggagga 360 tacatatggg aattgattga gttgacacac tgctctcaat taaacggttt aatggatgat 420 aattgtgaaa tcaaattttc taaaagacta agtgactcag taatgactaa ttatatgaat 480 caaatatctg acttacttgg gcttgatctc aattcatgaa ttatgtttag tctaattcaa 540 tagacatgtg tttattacca ttttagttaa tataaaaact catcaaaggg aaatggggca 600 cctaatcaat aataaactca caaaccatga gcactacaaa tgacaacact actatgcaaa 660 gattgatgat cacagacatg agacccctgt aataataaca caatggattc tctcttacca 720 aagaaat at cacacacaaa ttcatatact tgataaacaa tgaatgtatt gtaagaaaac 780 ttgatgaaag acaagctaca tttacattct tagtcaatta tgagatgaag ctactgcaca 840 aactagggag taccaaa tac aaaaaataca ctgaatataa tacaaaatat ggcactttcc 900 ccatgcctat atttatcaat cacggcgggt ttctagaatg tattggcatt aagcctacaa 960 aacacactcc tataatatac aaatatgacc tcaacccgtg aattccaaca aaaaaaccaa 1020 ccaaactatt cccaaccaaa cctcaaacaa cagtgctcaa tagttaagaa ggagctaatc 1080 attaaaaata cattttagta aaagtaaagc aattggggca caataacata aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cattaaataa ggatcagctg ctgtcatcca 1200 gcaaatacac tattcaacgt agtacaggag ataatattga cactcccaat tatgatgtgc 1260 aaaaacacct aaacaaacta tgtggtatgc tattaatcac tgaagatgca aatcataaat 1320 tcacaggatt aataggtatg ttatatgcta tgtccaggtt aggaagggaa gacactataa 1380 agatgctgga agatacttaa tatcatgtta aagctaatgg agtagatata acaacatatc 1440 gtcaagatat aaatggaaag gaaatgaaat tcgaagtatt aacattatca agcttgacat 1500 cagaaataca agtcaatatt gagatagaat ctagaaagtc ctacaaaaaa atgctaaaag 1560 agatgggaga agtggctcca gaatataggc atgattctcc agactgtggg atgataatac 1620 tgtgtatagc tgcacttgtg ataaccaaat tagcagcagg agacagatca ggtcttacag 1680 cagtaattag gagggcaaac aatgtcttaa aaaacgaaat aaaacgatac aagggcctca 1740 taccaaagga tatagctaac agtttttatg aagtgtttga aaaacaccct catcttatag 1800 atgttttcgt gcactttggc attgcacaat catccacaag agggggtagt agagttgaag 1860 gaatctttgc aggattgttt atgaatgcct atggttcagg gcaagtaatg ctaagatggg 1920 caaatctgta gagttttagc tgctaggaca aaaaatatca tgctagtgtc caggcagaaa 1980 tggagc AAGT tgtggaagtc tatgagtatg cacagaagtt gggaggagaa gctggattct 2040 accatatatt gaacaatcca aaagcatcat tgctgtcatt aactcaattt cccaacttct 2100 caagtgtggt cctaggcaat gcagcaggtc taggcataat gggagagtat agaggtacac 2160 caagaaacca ggatctttat gatgcagcta aagcatatgc agagcaactc aaagaaaatg 2220 ctacagtgta gagtaataaa ttagacttaa cagcagaaga attggaagcc ataaagcatc 2280 aactcaaccc caaagaagat gatgtagagc tttaagttaa caaaaaatac ggggcaaata 2340 agtcaacatg gagaagtttg cacctgaíatt tcatggagaa gatgcaaata acaaagctac 2400 caaattccta gaatcaataa agggcaagtt cgcatcatcc aaagatccta agaagaaaga 2460 tagcataata tctgttaact caatagatat agaagtaact aaagagagcc cgataacatc 2520 tggcaccaac atcatcaatc caacaagtga agccgacagt accccagaaa caaaagccaa 2580 ctacccaaga aaacccctag taagcttcaa agaagatctc accccaagtg acaacccttt 2640 ttctaagttg tacaaggaaa caatagaaac atttgataac aatgaagaag aatctagcta 2700 ctcatatgaa gagataaatg atcaaacaaa tgacaacatt acagcaagac tagatagaat 2760 ttaagtgaaa tgatgaaaaa tattaggaat gctccataca ttagtagttg caagtgcagg 2820 acccacttca gctcgcgatg gaataagaga tgctatggtt ggtctaagag aagagatgat 2880 agaaaaaata agagcggaag cattaategac caatgatagg ttagaggcta tggcaagact 2940 gaaagcgaaa taggaatgag aaatggcaaa agacacctca gatgaagtgt ctcttaatcc 3000 aacttccaaa aaattgagtg acttgttgga agacaacgat agtgacaatg atctatcact 3060 tgatcagcga tgatgatttt tcaactcact cagcaatcaa caacatcaat aaaacagaca 3120 tcaatccatt gaatcaactg ccagaccgaa caaacaaacg tccatcagta gaaccaccaa 3180 aaccaattga ccaatcaatc acccgacaaa tcaatcagca attaacaata tagtaacaaa 3240 gatggggcaa aaaagaacaa atatggaaac atacgtgaac aagcttcacg aaggctccac 3300 atacacagca gctgttcagt acaatgttct agaaaaagat gatgatcctg catcactaac 3360 aatatgggtg cctatgttcc agtcatctgt gccagcagac ttgctcataa aagaacttgc 3420 aagcatcaat atactagtga agcagatctc tacgcccaaa ggaccttcac tacgagtcac 3480 gattaactca agaagtgctg tgctggctca aatttcatca aatgcctagt taagcgcaaa 3540 tgtatcatta gatgaaagaa atatgatgta gcaaattagc gtgaaatcaa actacacctt 3600 agcatgcagt ctaacatgct aagtatgtta taaaagtaaa actacagtca aagatcttac 3660 ttcaacccca catgaagaca ctcatgagat cattgctcta tgtgaatttg aaaatattat 3720 gacatcaaaa taccaaccta agagtaataa tctaagatca attagtgtca agaacaagga 3780 ctagaaaata tctgaactca tagcaaccac cgaattcaaa aatgctatca ccaatgcaaa 3840 aattattcct tatgcaggat tagtgttagt tatcacagtt actgacaata aaggagcatt 3900 aaaccacaga caaatatatc gtcaatttat agtagatctt ggtgcctacc tagaaaaaga 3960 gagcatatat tatgtgacta ctaattggaa gcatacagct acacgttttt caatcaaacc 4020 actagaggat taaacttaat tatcaacact gaatgacagg tccacatata tcctcaaact 4080 acacactata tccaaacatc ataaacatct cttcatcaca acactacaca caaaccaatc 4140 tccaaaatca ccactcaaaa ctaccagcca ctatccgcta gacctagagt gcgaataggc 4200 aaataaaacd aaaatatggg gtaaatagac attagttaga gttcaatcaa tcttaacaac 4260 catttatacc gccaattcaa cacatatact ataaatctta aaatgggaaa tacatccatc 4320 acaatagaac tcacaagcaa attttggccc tattttacac taatacatat gatcttaact 4380 ctaatctttt tactaattat aatcactatc atgattgcaa gctaagtgaa cactaaataa 4440 cacaaagcat tctgcaacaa ctaggacaga aactcttgaa tgtaccaaat caacacacag 4500 ttatgctgtg agttccacca tcaaaccata atcctgtata tacaaacaaa caaatccaat 4560 cctctcacag agtcacggtg tcgcaaaacc acgctaacca tcatggtagc atagagtagt 4620 tatttaaaaa ttaacataat gatgaattgt tagtatgaga tcaaaaacaa cattggggca 4680 tgtccaaaca aatgcaacca caagaatcaa cgcactgcca ggactctaga aaagacctgg 4740 gatactctta atcatctaat tgtaatatcc tcttgtttat acagattaaa tttaaaatct 4800 atagcacaaa tagcactatc atgataatct agttttggca caacctctct cataattgca 4860 gccata atat tcatcatctc tgccaatcac aaagttacac taacaacggt cacagttcaa 4920 accacactga acaataaaaa aaaaaacatc accacctacc ctactcaagt ctcaccagaa 4980 agggttagtt catccaagca acccacaacc acatcaccaa tccacacaag ttcagctaca 5040 acatcaccca atacaaaatc agaaacacac catacáacag cacaaaccaa aggcagaacc 5100 cacagaccaa accacttcaa caagccaagc acaaaaccac tccaccaaaa gtccaaaaaa 5160 aaagatgatt accattttga agtgttcaac ttcgttccct gcagtatatg tggcaacaat 5220 aatccatctg caactttgca ccaagcaaca caaaacaata aaccaaagaa gaaaccaacc 5280 atcaaaccca caaacaaacc accacaaaca aaccaccaaa aaagagaccc aaaaacacca 5340 cgaaaaaaga gccaaaacga aactaccacc aacccaacaa aaaaactaac cctcaagacc 5400 acagaaagag acaccagcac ctcacaatcc actgcactcg acacaaccac attaaaacac 5460 acagtccaac agcaatccct cctctcaacc acccccgaaa ctccacacaa acacacccaa 5520 acacccacag catccgagcc ctccacacca aactccaccc aaaaaaccca gccacatgct 5580 tagttattca aaaactacat cttagcagag aaccgtgatc tatcaagcaa gaacgaaatt 5640 ca'aataacca aaacct'gggg tggagttgat gatccacaag tcaagtgcaa tcttcctaac 5700 tcttgctat t aatgcattgt acctcacctc aagtcagaac ataactgagg agttttacca 5760 atcgacatgt agtgcagtta gcagaggtta ttttagtgct ttaagaacag gttggtatac 5820 tagtgtcata acaatagaat taagtaatat aaaagaaacc aaatgcaatg gaactgacac 5880 cttatgaaac taaagtaaaa taagtataag aagaattaga cagaattaca aatgcagtaa 5940 gctacttatg caaaacacac cagctgtcaa caaccgggcc agaagagaag caccacagta 6000 acaatcaata tatgaactac ccactaaaaa cctaaatgta tcaataagca agaagaggaa 6060 acgaagattt ctaggcttct tgttaggtgt gggatctgca atagcaagtg gtatagctgt 6120 atcaaaagtt ctacaccttg aaggagaagt gaacaagatc aaaaatgctt tgttgtctac 6180 aaacaaagct gtagtcagtt tatcaaatgg ggtcagtgtt ttaaccagca aagtgttaga 6240 tctcaagaat tacataaata accaattatt acccatagta aatcaacaga gctgtcgcat 6300 gaaacagtta ctccaacatt tagaattcca gcagaagaac agcagattgt tggaaatcac 6360 agtgtcaatg cagagaattt caggtgtaac aacaccttta agcacttaca tgttgacaaa 6420 ctatcattaa cagtgagtta tcaatgatat gcctataaca aatgatcaga aaaaattaat 6480 gtcaagcaat gttcagatag taaggcaaca atcatgtcta aagttattcc taataaagga 6540 agaagtcctt gcat atgttg tacagctgcc tatctatggt gtaatagata caccttgctg 6600 gaaattgcac acatcgcctc tatgcactac caacatcaaa gaaggatcaa atatttgttt 6660 aacaaggact gatagaggat taatgcagga ggtattgtga tctttccaca tcagtatcct 6720 ggctgacact tgtaaagtac agtccaatcg agtattttgt gacactatga acagtttgac 6780 attaccaagt gaagtcagcc tttgtaacac tgacatattc aattccaagt atgactgcaa 6840 aattatgaca tcaaaaacag acataagcag ctcagtaatt acttctcttg gagctatagt 6900 gtcatgctat ggtaaaacta aatgcactgc atccaacaaa aatcgtggga ttataaagac 6960 attttctaat ggttgtgact atgtgtcaaa gatactgtgt caaaggagta cagtgggcaa 7020 tatgtaaaca cactttatac agctggaagg caagaacctt tatgtaaaag gggaacctat 7080 aataaattac tatgaccctc tagtgtttcc ttctgatgag tttgatgcat caatatctca 7140 agtcaatgaa aaaatcaatc aaagtttagc ttttattcgt agatctgatg aattactaca 7200 taatgtaaat actggcaaat ctactacaaa tattatgata actacaatta ttatagtaat 7260 cattgtagta ttgttatcat taatagctat tggtttactg ttgtattgta aagccaaaaa 7320 cacaccagtt acactaagca aagaccaact aagtggaatc aataatattg cattcagcaa 7380 atagacaaaa aaccacctga tcatgtttca acaacaatct gctgaccacc aatcccaaat 7440 caacttacaa caaatatttc aacatcacag tacaggctga atcatttcct cacatcatgc 7500 tacccacata actaagctag atccttaact tatagttaca taaaaacctc aagtatcaca 7560 atcaaccact aaatcaacac atcattcaca aaattaacag ctggggcaaa tatgtcgcga 7620 agaaatcctt gtaaatttga gattagaggt cattgcttga atggtagaag atgtcactac 7680 agtcataatt actttgaatg gcctcctcat gcattactag tgaggcaaaa cttcatgtta 7740 aacaagatac tcaagtcaat ggacaaaagc atagacactt tgtctgaaat aagtggagct 7800 gctgaactgg atagaacaga agaatatgct cttggtatag ttggagtgct agagagttac 7860 ataggatcta taaacaacat aacaaaacaa tcagcatgtg ttgctatgag taaacttctt 7920 atagtgatga attgagatca cattaaaaag cttagagata atgaagaacc caattcacct 7980 aagataagag tgtacaatac tgttatatca tacattgaga gcaatagaaa aaacaacaag 8040 atctgctcaa caaaccatcc gagactacca gcagacgtgc tgaagaagac aataaagaac 8100 acattagata tccacaaaag cataaccata agcaatccaa aagagtcaac tgtgaatgat 8160 caaaatgacc aaaccaaaaa taatgatatt accggataaa tatccttgta gtatatcatc 8220 catattgatc tcaagtgaaa gcatgg TTGC tacattcaat cataaaaaca tattacaatt 8280 taaccataac tatttggata accaccagcg tttattaaat catatatttg atgaaattca 8340 ttggacacct aaaaacttat tagatgccac tcaacaattt ctccaacatc ttaacatccc 8400 tgaagatata tatacagtat atatattagt gtcataatgc ttgaccataa cgactctatg 8460 tcatccaacc ataaaactat tttgataagg ttatgggaca aaatggatcc cattattaat 8520 ggaaactctg ctaatgtgta tctaactgat agttatttaa aaggtgttat ctctttttca 8580 gagtgtaatg ctttagggag ttatcttttt aacggccctt atcttaaaaa tgattacacc 8640 gtagacaaag aacttaatta cccactacta gagcatatga atcttaaaaa actaactata 8700 acacagtcat taatatctag atatcátaaa ggtgaactga aattagaaga accaacttat 8760 ttccagtcat tacttatgac atataaaagt atgtcctcgt ctgaacaaat tgctacaact 8820 aacttactta aaaaaataat acgaagagcc atagaaataa gtgatgtaaa ggtgtacgcc 8880 atcttgaata aactaggatt aaaggaaaag gacagagtta agcccaacaa taattcaggt 8940 gatgaaaact cagtacttac aaccataatt aaagatgata tactttcggc tgtggaaaac 9000 aatcaatcat atacaaattc agacaaaagt cactcagtaa atcaaaatat cactatcaaa 9060 tgaaaaaatt acaacactct gatgtgttca atgcaacatc ctccatcatg gttaatacac 9120 tggttcaatt tatatacaaa attaaataac atattaacac aatatcgatc aaatgaggta 9180 aaaagtcatg ggtttatatt aatagataat gtggttttca caaactttaa gtttatttta 9240 aatcaatatg gttgtatcgt ttatcataaa ggactcaaaa aaatcacaac tactacttac 9300 aatcaatttt tgacatggaa agacatcagc cttagcagat taaatgtttg cttaattact 9360 attgtttaaa tggataagta tacattaaac aaaagcttag ggctgagatg tggattcaat 9420 aatgttgtgt tatcacaatt atttctttat ggagattgta tactgaaatt atttcataat 9480 gaaggcttct acataataaa agaagtagag ggatttatta tgtctttaat tctaaacata 9540 atcaatttaa acagaagaag tataatagca gaaacgattt tgctaaataa catcacagat 9600 aggctcaaaa gcagctatta ggacctacta tcaagagtat gtcacacttt attagacaag 9660 acagtgtctg ataatatcat aaatggtaaa tggataatcc tattaagtaa atttcttaaa 9720 ttgcaggtga ttgattaagc taataatctc aataacttga gtgagctata ttttctcttc 9780 agaatctttg gacatccaat ggtcgatgaa agacaagcaa tggattctgt aagaattaac 9840 ctaagttcta tgtaatgaaa cttattaagt agtctaagta cattaagagg tgctttcatt 9900 tatagaatca taaaagggtt tgtaaatacc tacaacagat ggcccacctt aaggaatgct 9960 attgtcctac ctctaagatg gttaaactac tataaactta atacttatcc atctctactt 10020 gaaatcacag aaaatgattt gattatttta tcaggattgc ggttctatcg tgagtttcat 10080 aagtggatct ctgcctaaaa ataaatgaca tgaaatgáta aagccatttc acctccaaaa 10140 gatctaatat ggactagttt tcctagaaat tacatgccat cacatataca aaattatata 10200 gaacatgaaa agttgaagtt ctctgaaagc gacagatcga gaagagtact agagtattac 10260 ataaattcaa ttgagagata tgaatgcgat ctatacaatt gtgtagtcaa tcaaagctat 10320 ctcaacaact ctaatcacgt ggtatcacta actggtaaag aaagagagct cagtgtaggt 10380 agaatgtttg ctatgcaacc aggtatgttt aggcaaatcc aaatcttagc agagaaaatg 10440 atattttaca atagctgaaa attcttccct gagagtttga caagatatgg tgatctagag 10500 tattagaatt cttcaaaaga ataagcaaca aaaagcagga agtcaaatcg ttataatgat 10560 aactacaaca attatatcag taaatgttct atcattacag atcttagcaa attcaatcag 10620 gcatttagat atgaaacatc atgtatctgc agtgatgtat tagatgaact gcatggagta 10680 caatctctgt tctcttggtt gcatttaaca atacctcttg tcacaataat atgtacatat 10740 agacatgcac ctcctttcat aaaggatcat gttgttaatc ttaatgaggt tgatgaacaa 10800 agtggattat acagatatca tatgggtggt attgagggct ggtgtcaaaa actgtggacc 10860 attgaagcta tatcattatt agatctaata tctctcaaag ggaaattctc tatcacagct 10920 ctgataaatg gtgataatca gtcaattgat ataagcaaac cagttagact tatagagggt 10980 cacaagcaga cagacccatg ttatttgtta gcattaaata gttatataaa gccttaaatt 11040 gagtatgcag gtataggcca taagcttaag ggaacagaga cctatatatc ccgagatatg 11100 cagttcatga gcaaaacaat ccagcacaat ggagtgtact atccagccag tatcaaaaaa 11160 gtcctgagag taggtccatg gataaacacg atacttgatg attttaaagt tagtttagaa 11220 gcttaacaca tctataggca ggagttagaa tacagaggag aaagcttatt atgcagttta 11280 acatttggtt atatttagga attgctttgc atacaatcaa tcatgcatta aactccgaaa 11340 tgtaacaata agctatattt agatatattg aaagtattaa aacacttaaa aacttttttt 11400 aatcttgata gcattgatat ggctttatca ttgtatatga atttgcctat gct gtttggt 11460 ggtggtgatc ctaatttgtt atatcgaagc ttttatagga cttccttaca gaactccaga 11520 gaagctatag tacattcagt gtttgtgttg agctattata ctggtcacga tttacaagat 11580 aagctccagg -atcttccaga tgatagactg aacaaattct tgacatgtgt catcacattt 11640 ccaatgccga gataaaaatc gtttgtaaca ttgatgaggg atccacaggc tttagggtct 11700 gaaaggcaag ctaaaattac tagtgagatt aatagattag cagtaacaga agtcttaagt 11760 atagccccaa acaaaatatt ttctaaaagt gcacaacatt atactaccac tgagattgat 11820 ttatgcaaaa ctaaatgaca tatagaacca acttaccctc atggattaag agttgtttat 11880 gaaagtttac ctttttataa agcagaaaaa atagttaatc ttatatcagg aacaaaatcc 11940 tacttgaaaa ataactaata aacatcagca atagatacaa ctgatattaa tagggctact 12000 gatatgatga ggaaaaatat aactttactt ataaggatac ttgtaacaaa ttccactaga 12060 gacaaaagag agttattaag tttagaaaat cttagtataa ctgaattaag caagtatgta 12120 agagaaagat cttggtcatt atccaatata gtaggagtaa catcgccaag tattatgttc 12180 acaatgaaca ttaaatatac aactagcact atagccagtg gtataataat agaaaaatat 12240 gtttaactcg aatgttaata tggtgaaaga ggacccacca agcca tgggt aggctcatcc 12300 acgcaggaga aaaaaacaat gccagtgtac aacagacaag ttttaaccaa aaagcaaaga 12360 gaccaaatag atttattagc aaaattagac tgggtatatg catccataga caacaaagat 12420 gaattcatgg aagaactgag tactggaaca cttggactgt catatgaaaa agccaaaaag 12480 ttgtttccac aatatctaag tgtcaattat ttacaccgtt taacagtcag tagtagacca 12540 tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcattt tgatactagt 12600 cctatcaatc atgtattaac agaaaagtat ggagatgaag atatcgacat tgtgtttcaa 12660 aattgcataa gttttggcct tagcctgatg tcggttgtgg aacaattcac aaacatatgt 12720 cctaatagaa ttattctcat accgaagctg aatgagatac atttgatgaa acctcctata 12780 tttacaggag atgttgatat catcaagttg tacaaaagca aagcaagtga gcacatgttc 12840 ctaccagata aaataagttt aacccaatat gtagaattat tcttaagtaa caaagcactt 12900 aaatctggat ctcacatcaa ctctaattta atattagtac ataaaatgtc tgattatttt 12960 cataatgctt atattttaag tactaattta gctggacatt ggattctgat tattcaactt 13020 atgaaagatt caaaaggtat ttttgaaaaa gattggggag aggggtacat aactgatcat 13080 atgttcatta atttgaatgt tttctttaat gcttataaga cttatttgct atgttttcat 13140 aaaggttatg gtaaagcaaa attagaatgt gatatgaaca cttcagatct tctttgtgtt 13200 tagacagtag ttggagttaa ctactggaaa tctatgtcta aagttttcct agaacaaaaa 13260 acatagtcaa gtcataaaat tcaagacaca agtttgcgta gaataaaagg ctgtcacagt 13320 tttaagttgt ggtttttaaa acgccttaat aatgctaaat ttaccgtatg cccttgggtt 13380 gttaacatag attatcaccc aacacacatg aaagctatat tatcttacat agatttagtt 13440 agaatggggt taataaatgt agataaatta accattaaaa ataaaaacaa attcaatgat 13500 gaattttaca catcaaatct cttttacatt agttataact tttcagacaa cactcatttg 13560 ctaacaaaac aaataagaat tgctaattca gaattagaag ataattataa caaactatat 13620 cacccaaccc cagaaacttt agaaaatatg tcattaattc ctgttaaaag taataatagt 13680 aacaaaccta aattttgtat aagtggaaat accgaatcta tgatgatgtc aacattctct 13740 agtaaaatgc atattaaatc ttccactgtt accacaagat tcaattatag caaacaagac 13800 ttgtacaatt tatttccaat gacaagatta tgttgtgata aggtaataca tagatcattc 13860 accaacttta gcaaaatcta caccaccact tcacatcaga catctttagt aaggaatagt 13920 gcatcacttt attgcatgct tccttggcat cat gtcaata gatttaactt tgtatttagt 13980 tccacaggat gcaagatcag tatagagtat attttaaaag atcttaagat taaggacccc 14040 agttgtatag cattcatagg tgaaggagct ggtaacttat tattacgtac ggtagtagaa 14100 cttcatccag acataagaca catttacaga agtttaaaag tcatagttta attgcaatga 14160 cctattgaat ttctaaggtt atacaacggg catataaaca tagattatsg tgagaattta 14220 accattcctg ctacagatgc aactaataac attcattggt cttatttaca tataaaattt 14280 gcagaaccta ttagcatctt tgtctgcgat gctgaattac ctgttacagc caattggagt 14340 ttgaatggag aaaattataa taagcatgta agaaagtgca agtactgttc ttctgtaaat 14400 agatgcattt taattgcaaa atatcatgct caagatgaca ttgatttcaa attagataac 14460 attactatat taaaaactta cgtgtgccta ggtagcaagt taaaaggatc tgaagtttac 14520 ttaatcctta caataggccc tgcaaatata cttcctgttt ttgatgttgt acaaaatgct 14580 aaattgatac tttcaagaac taaaaatttc aaaaaactga attatgccta caaggaatct 14640 atcgatgcaa atattaaaag cttaatacct ttcctttgtt accctataac aaaaaaagga 14700 attaagactt cattgtcaaa attgaagagt gtagttaatg gagatatatt- atcatattct 14760 atagctggac gtaatgaagt attca gcaac aagcttataa accacaagca tatgaatatc 14820 ctaaaatggc tagatcatgt tttaaatttt agatcagctg aacttaatta caatcattta 14880 tacatgatag agtccacata tccttactta agtgaattgt taaatagttt aacaaccaat 14940 agctgattaa gagctcaaga aataacaggt agtgtgctat acaaccttcc caacgaacag 15000 tagtttaaaa tatcattaac aagtttggtc aaatttagat gctaacacat cattatatta 15060 agaatataca tagttattaa taatttagca aacttttcaa aaaattatca tattgattcc 15120 aaggggttaa ttttagtctt aaaactaaca ataaaagtct tgcattcaca attatacatg 15180 acacaacgag acattagttt ttgacacttt ttttctcgt 15219 < 210 > 14 < 211 > 15219 < 212 > DNA < 213 > human respiratory syncytial virus < 400 > 14 acgggaaaaa aatgcgtact acaaacttgc acattcgaaa aaaatggggc aaataagaac 60 ttgataagtg ctatttaagt ctaacctttt caatcagaaa tggggtgcaa ttcactgagc 120 atgataaagg ttagattaca aaatttattt gacaatgacg aagtagcatt gttaaaaata 180 acatgttata ctgataaatt aattcttctg accaatgcat tagccaaagc agcaatacat 240 acaattaaat taaacggcat agtttttata catgttataa caagcagtga agtgtgccct 300 gataacaata ttgtagtgaa atctaacttt acaacaatgc caatactaca aaatggagga 360 tacatatggg aattgattga gttgacacac tgctctcaat taaacggttt aatggatgat 420 aattgtgaaa tcaaattttc taaaagacta agtgactcag taatgactaa ttatatgaat 480 caaatatctg acttacttgg gcttgatctc aattcatgaa ttatgtttag tctaattcaa 540 tagacatgtg tttattacca ttttagttaa tataaaaact catcaaaggg aaatggggca 600 cctaatcaat aataaactca caaaccatga gcactacaaa tgacaacact actatgcaaa 660 gattgatgat cacagacatg agacccctgt aataataaca caatggattc tctcttacca 720 aagaaatcat cacacacaaa ttcatatact tgataaacaa tgaatgtatt gtaagaaaac 780 ttgatgaaag acaagctaca tttacattct tagtcaatta tgagatgaag ctactgcaca 840 aagtagggag taccaaa tac aaaaaataca ctgaatataa tacaaaatat ggcactttcc 900 ccatgcctat atttatcaat cacggcgggt ttctagaatg tattggcatt aagcctacaa 960 aacacactcc tataatatac aaatatgacc tcaacccgtg aattccaaca aaaaaaccaa 1020 ccaaactatt cccaaccaaa cctcaaacaa cagtgctcaa tagttaagaa ggagctaatc 1080 attaaaaata cattttagta aaagtaaagc aattggggca caataacata aatacaaaga 1140 tggctcttag caaagtcaag ttgaatgata cattaaataa ggatcagctg ctgtcatcca 1200 gcaaatacac tattcaacgt agtacaggag ataatattga cactcccaat tatgatgtgc 1260 aaacaaacta aaaaacacct tgtggtatgc tattaatcac tgaagatgca aatcataaat 1320 tcacaggatt aataggtatg ttatatgcta tgtccaggtt aggaagggaa gacactataa 1380 agatgctgga agatacttaa tatcatgtta aagctaatgg agtagatata acaacatatc 1440 gtcaagatat aaatggaaag gaaatgaaat tcgaagtatt aacattatca agcttgacat 1500 cagaaataca agtcaatatt gagatagaat ctagaaagtc ctacaaaaaa atgctaaaag 1560 agtggctcca agatgggaga gaatataggc atgattctcc agactgtggg atgataatac 1620 tgtgtatagc tgcacttgtg ataaccaaat tagcagcagg agacagatca ggtcttacag 1680 cagtaattag gagggcaaac AATG tcttaa aaaacgaaat aaaacgatac aagggcctca 1740 taccaaagga tatagctaac agtttttatg aagtgtttga aaaacaccct catcttatag 1800 atgttttcgt gcactttggc attgcacaat catccacaag agggggtagt agagttgaag 1860 gaatctttgc aggattgttt atgaatgcct atggttcagg gcaagtaatg ctaagatggg 1920 caaatctgta gagttttagc tgctaggaca aaaaatatca caggcagaaa tgctagtgtc 1980 tggagcaagt tgtggaagtc tatgagtatg cacagaagtt gggaggagaa gctggattct 2040 gaacaatcca accatatatt aaagcatcat tgctgtcatt aactcaattt cccaacttct 2100 caagtgtggt cctaggcaat gcagcaggtc taggcataat gggagagtat agaggtacac 2160 caagaaacca ggatctttat gatgcagcta aagcatatgc agagcaactc aaagaaaatg 2220 ctacagtgta gagtaataaa ttagacttaa cagcagaaga attggaagcc ataaagcatc 2280 aactcaaccc caaagaagat gatgtagagc tttaagttaa caaaaaatac ggggcaaata 2340 agtcaacatg gagaagtttg cacctgaatt tcatggagaa gatgcaaata acaaagctac 2400 gaatcaataa caaattccta agggcaagtt cgcatcatcc aaagatccta agaagaaaga 2460 tagcataata tctgttaact caatagatat agaagtaact aaagagagcc cgataacatc 2520 tggcaccaac atcatcaatc caacaagtga agccgacagt accccagaaa caaaagccaa 2580 ctacccaaga aaacccctag taagcttcaa agaagatctc accccaagtg acaacccttt 2640 ttctaagttg tacaaggaaa caatagaaac atttgataac aatgaagaag aatctagcta 2700 ctcatatgaa gagataaatg atcaaacaaa tgacaacatt acagcaagac tagatagaat 2760 tgatgaaaaa ttaagtgaaa tattaggaat gctccataca ttagtagttg caagtgcagg 2820 acccacttca gctcgcgatg gaataagaga tgctatggtt ggtctaagag aagagatgat 2880 agaaaaaata agagcggaag cattaatgac caatgatagg ttagaggcta tggcaagact 2940 gaaagcgaaa taggaatgag agacacctca aaatggcaaa gatgaagtgt ctcttaatcc 3000 aacttccaaa aaattgagtg acttgttgga agacaacgat agtgacaatg atctatcact 3060 tgatcagcga tgatgatttt tcaactcact cagcaatcaa aaaacagaca caacatcaat 3120 tcaatccatt gaatcaactg ccagaccgaa caaacaaacg tccatcagta gaaccaccaa 3180 ccaatcaatc aaccaattga tcaatcagca acccgacaaa attaacaata tagtaacaaa 3240 aaaagaacaa gatggggcaa atatggaaac atacgtgaac aagcttcacg aaggctccac 3300 atacacagca gctgttcagt acaatgttct agaaaaagat gatgatcctg catcactaac 3360 aatatgggtg cctatgttcc agtcatctgt gccagcagac ttgctcataa aagaacttgc 3420 aagcatcaat atactagtga agcagatctc tacgcccaaa ggaccttcac tacgagtcac 3480 gattaactca agaagtgctg tgctggctca aatttcatca aatgcctagt taagcgcaaa 3540 tgtatcatta gatgaaagaa atatgatgta gcaaattagc gtgaaatcaa actacacctt 3600 agcatgcagt ctaacatgct aagtatgtta taaaagtaaa actacagtca aagatcttac 3660 ttcaacccca catgaagaca ctcatgagat cattgctcta tgtgaatttg aaaatattat 372.0 gacatcaaaa taccaaccta agagtaataa tctaagatca attagtgtca agaacaagga 3780 ctagaaaata tctgaactca tagcaaccac cgaattcaaa aatgctatca ccaatgcaaa 3840 aattattcct tatgcaggat tagtgttagt tatcacagtt actgacaata aaggagcatt 3900 aaaccacaga caaatatatc gtcaatttat agtagatctt ggtgcctacc tagaaaaaga 3960 gagcatatat tatgtgacta ctaattggaa gcatacagct acacgttttt caatcaaacc 4020 actagaggat taaacttaat tatcaacact gaatgacagg tccacatata tcctcaaact 4080 acacactata tccaaacatc ataaacatct acactacaca cttcatcaca caaaccaatc 4140 ccactcaaaa ctaccagcca tccaaaatca ctatctgcta gacctagagt gcgaataggt 4200 aaataaaacc aaaatatggg gtaaatagac attagttaga gttcaatcaa tcttaacaac 4260 catttatacc gccaattcaa cacatatact ataaatctta aaatgggaaa tacatccatc 4320 acaatagaat tcacaagcaa attttggccc tattttacac taatacatat gatcttaact 4380 ctaatctttt tactaattat aatcactatt atgattgcaa tactaaataa gctaagtgaa 4440 cataaagcat tctgtaacaa aactcttgaa ctaggacaga tgtatcaaat caacacatag 4500 agttctacca ttatgctgtg tcaaattata atcctgtata tataaacaaa caaatccaat 4560 cttctcacag agtcatggtg tcgcaaaacc acgctaacta tcatggtagc atagagtagt 4620 tatttaaaaa ttaacataat gatgaattgt tagtatgaga tcaaaaacaa cattggggca 4680 aatgcaacca tgtccaaaca cgcactgcca caagaatcaa ggactctaga aaagacctgg 4740 gatactctta atcatctaat tgtaatatcc tcttgtttat acagattaaa tttaaaatct 4800 tagcactatc atagcacaaa agttttggca atgataatct cataattgca caacctctct 4860 gccataatat tcatcatctc tgccaatcac aaagttacac taacaacggt cacagttcaa 4920 accacactga acaataaaaa aaaaaacatc accacctacc ctactcaagt ctcaccagaa 4980 agggtt AGTT catccaagca acccacaacc acatcaccaa tccacacaag ttcagctaca 5040 acatcaccca atacaaaatc agaaacacac catacaacag cacaaaccaa aggcagaacc 5100 cacagaccaa accacttcaa acaaaaccac caagccaagc tccaccaaaa gtccaaaaaa 5160 aaagatgatt accattttga agtgttcaac ttcgttccct gcagtatatg tggcaacaat 5220 caactttgca aatccatctg caaaacaata ccaagcaaca aaccaaagaa gaaaccaacc 5280 caaacaaacc atcaaaccca accacaaaca aaccaccaaa aaaaacacca aaagagaccc 5340 cgaaaaaaga gccaaaacga aactaccacc aacccaacaa aaaaactaac cctcaagacc 5400 acagaaagag acaccagcac ctcacaatcc actgcactcg acacaaccac attaaaacac 5460 acagtccaac agcaatccct cctctcaacc acccccgaaa acacacccaa ctccacacaa 5520 acacccacag catccgagcc ctccacacca aactccaccc aaaaaaccca gccacatgct 5580 tagttattca aaaactacat cttagcagag aaccgtgatc tatcaagcaa gaacgaaatt 5640 aaacctgggg caaataacca tggagttgát gatccacaag tcaagtgcaa tcttcctaac 5700 tcttgctatt aatgcattgt acctcacctc aagtcagaac ataactgagg agttttacca 5760 atcgacatgt agtgcagtta gcagaggtta ttttagtgct ttaagaacag gttggtatac 5820 tagtgtcata acaatagaat taagtaatat aaaagaaacc aaatgcaatg gaactgacac 5880 cttatgaaac taaagtaaaa aagaattaga taagtataag aatgcagtaa cagaattaca 5940 gctacttatg caaaacacac cagctgtcaa caaccgggcc agaagagaag caccacagta 6000 acaatcaata tatgaactac ccactaaaaa cctaaatgta tcaataagca agaagaggaa 6060 acgaagattt ctaggcttct tgttaggtgt gggatctgca atagcaagtg gtatagctgt 6120 atcaaaagtt ctacaccttg aaggagaagt gaacaagatc aaaaatgctt tgttgtctac 6180 aaacaaagct gtagtcagtt tatcaaatgg ggtcagtgtt ttaaccagca aagtgttaga 6240 tctcaagaat tacataaata accaattatt acccatagta aatcaacaga gctgtcgcat 6300 gaaacagtta ctccaacatt tagaattcca gcagaagaac agcagattgt tggaaatcac 6360 agtgtcaatg cagagaattt caggtgtaac aacaccttta agcacttaca tgttgacaaa 6420 ctatcattaa cagtgagtta tcaatgatat gcctataaca aatgatcaga aaaaattaat 6480 gtcaa gcaat gttcagatag taaggcaaca atcatgtcta aagttattcc taataaagga 6540 agaagtcctt gcatatgttg tacagctgcc tatctatggt gtaatagata caccttgctg 6600 gaaattgcac acatcgcctc tatgcactac caacatcaaa gaaggatcaa atatttgttt 6660 aacaaggact gatagaggat taatgcagga ggtattgtga tctttccaca tcagtatcct 6720 ggctgacact tgtaaagtac agtccaatcg agtattttgt gacactatga acagtttgac 6780 attaccaagt gaagtcagcc tttgtaacac tgacatattc aattccaagt atgactgcaa 6840 aattatgaca tcaaaaacag acataagcag ctcagtaatt acttctcttg gagctatagt 6900 gtcatgctat ggtaaaacta atccaacaaa aatgcactgc aatcgtggga ttataaagac 6960 attttctaat ggttgtgact atgtgtcaaa gatactgtgt caaaggagta cagtgggcaa 7020 tatgtaaaca cactttatac agctggaagg caagaacctt tatgtaaaag gggaacctat 7080 aataaattac tatgaccctc tagtgtttcc ttctgatgag tttgatgcat caatatctca 7140 agtcaatgaa aaaatcaatc aaagtttagc ttttattcgt agatctgatg aattactaca 7200 taatgtaaat actggcaaat ctactacaaa tattatgata actacaatta ttatagtaat 7260 cattgtagta ttgttatcat taatagctat tggtttactg ttgtattgta aagccaaaaa 7320 cacaccagtt acactaagca aagaccaact aagtggaatc aataatattg cattcagcaa 7380 aaccacctga atagacaaaa tcatgtttca acaacaatct gctgaccacc aatcccaaat 7440 caacttacaa caaatatttc aacatcacag tacaggctga atcatttcct cacatcatgc 7500 tacccacata actaagctag atccttaact tatagttaca taaaaacctc aagtatcaca 7560 atcaaccact aaatcaacac atcattcaca aaattaacag ctggggcaaa tatgtcgcga 7620 agaaatcctt gtaaatttga gattagaggt cattgcttga atggtagaag atgtcactac 7680 agtcataatt actttgaatg gcctcctcat gcattactag tgaggcaaaa cttcatgtta 7740 aacaagatac tcaagtcaat ggacaaaagc atagacactt tgtctgaaat aagtggagct 7800 gctgaactgg atagaacaga agaatatgct cttggtatag ttggagtgct agagagttac 7860 ataggatcta taaacaacat aacaaaacaa tcagcatgtg ttgctatgag taaacttctt 7920 atagtgatga attgagatca cattaaaaag cttagagata atgaagaacc caattcacct 7980 aagataagag tgtacaatac tgttatatca tacattgaga gcaatagaaa aaacaacaag 8040 atctgctcaa caaaccatcc gagactacca gcagacgtgc tgaagaagac aataaagaac 8100 acattagata tccacaaaag cataaccata agcaatccaa aagagtcaac tgtgaatgat 8160 aaacca caaaatgacc aaaa taatgatatt accggataaa tatccttgta gtatatcatc 8220 catattgatc tcaagtgaaa gcatggttgc tacattcaat cataaaaaca tattacaatt 8280 taaccataac tatttggata accaccagcg tttattaaat catatatttg atgaaattca 8340 ttggacacct aaaaacttat tagatgccac tcaacaattt ctccaacatc ttaacatccc 8400 tgaagatata tatacagtat atatattagt gtcataatgc ttgaccataa cgactctatg 8460 tcatccaacc ataaaactat tttgataagg ttatgggaca aaatggatcc cattattaat 8520 ggaaactctg ctaatgtgta tctaactgat agttatttaa aaggtgttat ctctttttca 8580 gagtgtaatg ctttagggag ttatcttttt aacggccctt atcttaaaaa tgattacacc 8640 gtagacaaag aacttaatta cccactacta gagcatatga actaactata atcttaaaaa 8700 acacagtcat taatatctag atatcataaa ggtgaactga aattagaaga accaacttat 8760 ttccagtcat tacttatgac atataaaagt atgtcctcgt ctgaacaaat tgctacaact 8820 aacttactta aaaaaataat acgaagagcc atagaaataa gtgatgtaaa ggtgtacgcc 8880 atcttgaata aactaggatt aaaggaaaag gacagagtta agcccaacaa taattcaggt 8940 gatgaaaact cagtacttac aactataatt aaagatgata tactttcggc tgtggaaaac 9000 aatcaatcat atacaaattc agacaaaagt cactcagtaa atcaaaatat cactatcaaa 9060 acaacactct tgaaaaaatt gatgtgttca atgcaacatc ctccatcatg gttaatacac 9120 tggttcaatt tatatacaaa attaaataac atattaacac aatatcgatc aaatgaggta 9180 aaaagtcatg ggtttatatt aatagataat gtggttttca caaactttaa gtttatttta 9240 aatcaatatg gttgtatcgt ttatcataaa ggactcaaaa aaatcacaac tactacttac 9300 aatcaatttt tgacatggaa agacatcagc cttagcagat taaatgtttg cttaattact 9360 attgtttaaa tggataagta tacattaaac aaaagcttag ggctgagatg tggattcaat 9420 aatgttgtgt tatcacaatt atttctttat ggagattgta tactgaaatt atttcataat 9480 gaaggcttct acataataaa agaagtagag ggatttatta tgtctttaat tctaaacata 9540 acagaagaag atcaatttag gaaacgattt tataatagca tgctaaataa catcacagat 9600 aggctcaaaa gcagctatta ggacctacta tcaagagtat gtcacacttt attagacaag 9660 acagtgtctg ataatatcat aaatggtaaa tggataatcc tattaagtaa atttcttaaa 9720 ttgattaagc ttgcaggtga aataacttga taataatctc gtgagctata ttttctcttc 9780 agaatctttg gacatccaat ggtcgatgaa agacaagcaa tggattctgt aagaattaac 9840 ctaagttcta tgtaatgaaa cttatt AAGT agtctaagta cattaagagg tgctttcatt 9900 tatagaatca taaaagggtt tgtaaatacc tacaacagat ggcccacctt aaggaatgct 9960 attgtcctac ctctaagatg sttaaactac tataaactta atacttatcc atctctactt 10020 gaaatcacag aaaatgattt gattatttta tcaggattgc ggttctatcg tgagtttcat 10080 aagtggatct ctgcctaaaa tgaaatgata ataaatgaca aagccatttc acctccaaaa 10140 gatctaatat ggactagttt tcctagaaat tacatgccat cacatataca aaattatata 10200 gaacatgaaa agttgaagtt ctctgaaagc gacagatcga gaagagtact agagtattac 10260 ataaattcaa ttgagagata tgaatgcgat ctatacaatt gtgtagtcaa tcaaagctat 10320 ctcaacaact ctaatcacgt ggtatcacta actggtaaag aaagagagct cagtgtaggt 10380 agaatgtttg ctatgcaacc aggtatgttt aggcaaatcc aaatcttagc agagaaaatg 10440 atattttaca atagctgaaa attcttccct gagagtttga caagatatgg tgatctagag 10500 tattagaatt cttcaaaaga aaaagcagga ataagcaaca agtcaaatcg ttataatgat 10560 aactacaaca attatatcag taaatgttct atcattacag atcttagcaa attcaatcag 10620 gcatttagat atgaaacatc atgtatctgc agtgatgtat tagatgaact gcatggagta 10680 caatctctgt tctcttggtt gcatttaaca atacctcttg tcacaataat atgtacatat 10740 agacatgcac ctcctttcat aaaggatcat gttgttaatc ttaatgaggt tgatgaacaa 10800 agtggattat acagatatca tatgggtggt attgagggct ggtgtcaaaa actgtggacc 10860 attgaagcta tatcattatt agatctaata tctctcaaag ggaaattctc tatcacagct 10920 ctgataaatg gtgataatca gtcaattgat ataagcaaac cagttagact tatagagggt 10980 cacaagcaga cagacccatg gcattaaata ttatttgtta gttatataaa gccttaaatt 11040 gagtatgcag gtataggcca taagcttaag ggaacagaga cctatatatc ccgagatatg 11100 cagttcatga gcaaaacaat ccagcacaat ggagtgtact atccagccag tatcaaaaaa 11160 gtcctgagag taggtccatg gataaacacg atacttgatg attttaaagt tagtttagaa 11220 gcttaacaca tctataggca ggagttagaa tacagaggag aaagcttatt atgcagttta 11280 acatttggtt atatttagga attgctttgc atacaatcaa tcatgcatta aactccgaaa 11340 tgtaacaata agctatattt agatatattg aaagtattaa aacacttaaa aacttttttt 11400 aatcttgata gcattgatat ggccttatca ttgtátatga atttgcctat gctgtttggt 11460 ggtggtgatc ctaatttgtt atatcgaagc ttttatagga cttccttaca gaactccaga 11520 gaagctatag tacattcagt gtttg GTTG agctattata ctggtcacga tttacaagat 11580 aagctccagg atcttccaga tgatagactg aacaaattct tgacatgtgt catcacattt 11640 ccaatgccga gataaaaatc gtttgtaaca ttgatgaggg atccacaggc tttagggtct 11700 gaaaggcaag ctaaaattac tagtgagatt aatagattag cagtaacaga agtcttaagt 11760 atagccccaa acaaaatatt ttctaaaagt gcacaacatt atactaccac tgagattgat 11820 ctaaatgaca tatagaacca ttatgcaaaa acttaccctc atggattaag agttgtttat 11880 gaaagtttac ctttttataa agcagaaaaa atagttaatc ttatatcagg aacaaaatcc 11940 tacttgaaaa ataactaata atagatacaa aacatcagca ctgatattaa tagggctact 12000 gatatgatga ggaaaaatat aactttactt ataaggatac ttgtaacaaa ttccactaga 12060 gacaaaagag agttattaag tttagaaaat cttagtataa ctgaattaag caagtatgta 12120 agagaaagat cttggtcatt atccaatata gtaggagtaa catcgccaag tattatgttc 12180 acaatggaca ttaaatatac aactagcact atagccagtg gtataataat agaaaaat at 12240 gtttaactcg aatgttaata tggtgaaaga ggacccacca agccatgggt aggctcatcc 12300 acgcaggaga aaaaaacaat gccagtgtac aacagacaag ttttaaccaa aaagcaaaga 12360 gaccaaatag atttattagc aaaattagac tgggtatatg catccataga caacaaagat 12420 gaattcatgg aagaactgag tactggaaca cttggactgt catatgaaaa agccaaaaag 12480 ttgtttccac aatatctaag tgtcaattat ttacaccgtt taacagtcag tagtagacca 12540 tgtgaattcc ctgcatcaat accagcttat agaacaacaa attatcattt tgatactagt 12600 cctatcaatc atgtattaac agaaaagtat ggagatgaag atatcgacat tgtgtttcaa 12660 aattgcataa gttttggtct tagcctgatg tcggttgtgg aacaattcac aaacatatgt 12720 cctaatagaa ttattctcat accgaagctg aatgagatac atttgatgaa acctcctata 12780 tttacaggag atgttgatat catcaagttg tacaaaagca aagcaagtga gcacatgttc 12840 ctaccagata aaataagttt aacccaatat gtagaattat tcttaagtaa caaa cactt 12900 aaatctggat ctcacatcaa ctctaattta atattagtac ataaaatgtc tgattatttt 12960 cataatgctt atattttaag tactaattta gctggacatt ggattctgat tattcaactt 13020 atgaaagatt caaaaggtat ttttgaaaaa gattggggag aggggtacat aactgatcat 13080 atgttcatta atttgaatgt tttctttaat gcttataaga cttatttgct atgttttcat 13140 aaaggttatg gt.aaagcaaa attagaatgt gatatgaaca cttcagatct tctttgtgtt 13200 tagacagtag ttggagttaa ctactggaaa tctatgtcta aagttttcct agaacaaaaa 13260 acatagtcaa gtcataaaat tcaagacaca agtttgcgta gaataaaagg ctgtcacagt 13320 tttaagttgt ggtttttaaa acgccttgat aatgctaaat ttaccgtatg cccttgggtt 13380 gttaacatag attatcaccc aacacacatg aaagctatat tatcttacat agatttagtt 13440 agaatggggt taataaatgt agataaatta accattaaaa ataaaaacaa attcaatgat 13500 gaattttaca catcaaatct cttttacatt agttataact tttcagacaa cactcatttg 13560 ctaacaaaac aaataagaat tgctaattca gaattagaag ataattataa caaactatat 13620 cacccaaccc cagaaacttt agaaaatatg tcattaattc ctgttaaaag taataatagt 13680 aacaaaccta aattttgtat aagtggaaat accgaatcta tgatgatgtc aacattctct 13740 agtaaaatgc atattaaatc ttccactgtt accacaagat tcaattatag caaacaagac 13800 ttgtacaatt tatttccaat gacaagatta tgttgtgata aggtaataca tagatcattc 13860 accaacttta gcaaaatcta caccaccact tcacatcaga ca tctttagt aaggaatagt 13920 gcatcacttt attgcátgct tccttggcat catgtcaata gatttaactt tgtatttagt 13980 tccacaggat gcaagatcag tatagagtat attttaaaag atcttaagat taaggacccc 14040 agttgtatag cattcatagg tgaaggagct ggtaacttat tattacgtac ggtagtagaa 14100 acataagata cttcatccag catttacaga agtttaaaag tcatagttta attgcaatga 14160 cctattgaat ttctaaggtt atacaacggg catataaaca tagattatgg tgagaattta 14220 accattcctg ctacagatgc aactaataac attcattggt cttatttaca tataaaattt 14280 gcagaaccta ttagcatctt tgtctgcgat gctgaattac ctgttacagc caattggagt 14340 aaaattataa ttgaatggag taagcatgta agaaagtgca agtactgttc ttctgtaaat 14400 agatgcattt taattgcaaa atatcatgct ttgatttcaa caagatgaca attagataac 14460 attactatat taaaaactta cgtgtgccta ggtagcaagt taaaaggatc tgaagtttac 14520 ttaatcctta caataggccc tgcaaatata cttcctgttt ttgatgttgt acaaaatgct 14580 aaattgatac tttcaagaac taaaaatttc attatgccta aaaaaactga caaggaatct 14640 atcgatgcag ttattaaaag cttaatacct ttcctttgtt accctataac aaaaaaagga 14700 attaagactt cattgtcaaa attgaagagt gtagttaatg gagatatatt atcatattct 14760 atagctggac gtaatgaagt attcagcaac aagcttataa accacaagca tatgaatatc 14820 ctaaaatggc tagatcatgt tttaaatttt agatcagctg aacttaatta caatcattta 14880 tacatgatag agtccacata tccttactta agtgaattgt taaatagttt aacaaccaat 14940 agctgattaa gagctcaaga aataacaggt agtgtgctat acaaccttcc caacgaacag 15000 tagtttaaaa tatcattaac aagtttggtc aaatttagat gctaacacat cattatatta 15060 aaaatataca tagttattaa taatttagca aacttttcaa aaaattatca tattgattcc 15120 ttttagtctt aaggggttaa ataaaagtct aaaactaaca attatacatg tgcattcaca 15180 acacaacgag acattagttt ttgacacttt ttttctcgt 15219 < 210 > 15 < 211 > 24 < 212 > DNA < 213 > Measles virus < 400 > 15 catatcactc actctgggat ggag 24 < 210 > 16 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 16 tcagaacatc aagcaccgcc 20 < 210 > 17 < 211 > 20 < 212 > DNA < 213 > Viru s of l S ar amp i ón < 400 > 17 acagtcaaga ctgagatgag 20 < 210 > 18 < 211 > 20 < 212 > AD < 213 > Measles virus < 400 > 18 aagagtcaga tacatgtgga 20 < 210 > 19 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 19 acatgaatca gcctaaagtc 20 < 210 > 20 < 211 > 25 < 212 > DNA < 213 > Measles virus < 400 > 20 ccgaaagagt tcctgcgtta cgacc 25 < 210 > 21 < 211 > 20 < 212 > DNA < 213 > Measles Virus < 400 > 21 cagtccacac aagtaccagg 20 < 210 > 22 < 211 > 20 < 212 > DNA < 213 > measles irus < 400 > 22 gtcagaagct gtggaccatc 20 < 210 > 23 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 23 aatattgcta caacaatggc 20 < 210 > 24 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 24 actcttcatt cctagactgg 20 < 210 > 25 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 25 gtccaattat gactatgaac 20 < 210 > 26 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 26 agaacagaca tgaagcttgc 20 < 210 > 27 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 27 ccaacaagga atgcttctag 20 < 210 > 28 < 211 > 25 < 212 > DNA < 213 > Measles virus < 400 > 28 acagcactat ctatgattga cctgg 25 < 210 > 29 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 29 gcaacatggt ttacacatgc 20 < 210 > 30 < 211 > 20 < 212 > DNA < 213 > measles irus < 400 > 30 agattgagag ttgatccagg 20 < 210 > 31 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 31 aggagatact taaactaagc 20 < 210 > 32 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 32 taagcttatg cctttcagcg 20 < 210 > 33 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 33 ttaacggacc laagctgtgc 20 < 210 > 34 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 34 gaaacagatt attatgacgg 20 < 210 > 35 < 211 > 24 < 212 > DNA < 213 > Measles virus < 400 > 35 cgggctatct aggtgaactt cagg 24 < 210 > 36 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 36 atttggatat ggaatatgag 20 < 210 > 37 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 37 actcaactga actaccagtg 20 < 210 > 38 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 38 aagaacatca tgtatttcag 20 < 210 > 39 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 39 ttatcaacgc actgctcatg 20 < 210 > 40 < 211 > 25 < 212 > DNA < 213 > measles irus < 400 > 40 attttcagca atcacttggc atgcc 25 < 210 > 41 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 41 gcctctgtgc aaacaagctg 20 < 210 > 42 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 42 tctctagtta ctctagcagc 20 < 210 > 43 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 43 aggtcgttgt ttgtgaggag 20 < 210 > 44 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 44 tcgtcctctt ctttactgtc 20 < 210 > 45 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 45 ccgtcctcga gctagcctcg 20 < 210 > 46 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 46 ctcctccagg ctcacattgg 20 < 210 > 47 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 47 gggttggtac atagctctgc 20 < 210 > 48 < 211 > 25 < 212 > DNA < 213 > Measles virus < 400 > 48 cacccatctg atatttccct gatgg 25 < 210 > 49 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 49 tggttgacag tacaaatctg 20 < 210 > 50 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 50 ctgaaatggg aagattgtgc 20 < 210 > 51 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 51 agcaatctac actgcctacc 20 < 210 > 52 < 211 > 20 < 212 > DNA < 213 > Measles virus < 400 > 52 tcacagatga ttcaattatc 20 < 210 > 53 < 211 20 < 212 > DNA < 213 > Measles virus < 400 > 53 gatcctagat ataagttctc 20 < 210 > 54 < 211 > 21 < 212 > DNA < 213 > Measles virus < 400 > 54 accaaacaaa gttgggtaag g 21 < 210 > 55 < 211 > 32 < 212 > DNA < 213 > Sarampon virus ón < 400 > 55 gggggatcca tccctaatcc tgctcttgtc ce 32 < 210 > 56 < 211 > 20 < 212 > DNA < 213 > Measles Virus < 400 > 56 gattectetg atggctccac 20 < 210 > 57 < 211 > 21 < 212 > DNA < 213 > Measles virus < 400 > 57 taacagtcaa ggagaccaaa g 21 < 210 > 58 < 211 > 32 < 212 > DNA < 213 > Measles virus < 400 > 58 gggaagctta accctaatcc tgccctaggt gg 32 < 210 > 59 < 211 > 22 < 212 > DNA < 213 > Measles virus < 400 > 59 accagacaaa gctgggaata ga 22 It is noted that in relation to this date, the best method known to the applicant to carry out the aforementioned invention, is that which is clear from the present description of the invention. Having described the invention as above, the content of the following is claimed as property:

Claims (25)

1. A measles virus, attenuated, isolated, recombinantly generated, characterized in that it has one or more attenuating mutations selected from the group consisting of: (a) for the N gene, changes in nucleotides that produce changes in an amino acid selected from the group consisting of residues 129 (glutamine-lysine), 148 (glutamic acid-glycine) and 479 (serine -> threonine); (b) for the P gene, changes in the nucleotides that produce changes in an amino acid selected from the group consisting of residues 225 (glutamic acid -> glycine), 275 (cysteine - »tyrosine) and 439 (leucine -» p ro 1 i na); (c) for gene C, changes in nucleotides that produce changes in an amino acid selected from the group consisting of residues 73 (alanine? valine), 104 (methionine - threonine) and 134 (serine - »tyrosine); Y (d) for the signal of termination of the F gene, the change in nucleotide 7243 (T -> C), where these nucleotides are presented in the sense of the message, antigenomic, with strand pos i ti a.

2. The measles virus according to claim 1, characterized in that it further comprises: (a) at least one attenuating mutation in the region of the 3 'genic promoter selected from the group consisting of nucleotide 26 (A - »T), nucleotide 42 (A? T or A -> C) and nucleotide 96 (G-A), where these nucleotides are presented in the sense of the message, antigenomic, positive-strand; and (b) at least one attenuating mutation in the RNA polymerase gene selected from the group consisting of changes in nucleotides, which produce changes in an amino acid selected from the group consisting of residues 331 (isoleucine - »threonine), 1409 ( alanine - threonine), 1624 (threonine - »alanine), 1649 (arginine - methionine), 1717 (aspartic acid -» alanine), 1936 (histidine - > tyrosine), 2074 (glutamine - »arginine) and 2114 (arginine - lysine).

3. A subgroup B of human respiratory syncytial virus (RSV) attenuated, isolated, recombinantly generated, characterized in that it has an attenuating mutation in the termination signal of the M gene at nucleotide 4199 (T - »C), where these nucleotides occur in the meaning of the message, antigenomic, of strand pos i ti a.

4. The subgroup B of the RSV according to claim 3, characterized in that it further comprises: (a) at least one attenuating mutation in the region of the 3 'genomic promoter selected from the group consisting of nucleotide 4 (C - »G) and the insertion of an additional A in the stretch of A in nucleotides 6-11, where these nucleotides are presented in the sense of the message, antigenomic, positive strand; and (b) at least one attenuating mutation in the RNA polymerase gene, selected from group consisting of changes in nucleotides, which produce changes in an amino acid selected from the group consisting of residues 353 (arginine-lysine), 451 (lysine-i> arginine), 1229 (aspartic acid - »asparagine), 2029 (threonine - > isoleucine) and 2050 (asparagine - »aspartic acid).

5. The subgroup B of RSV in accordance with re-excitation 4, characterized in that it includes the insertion of an additional A in the stretch of A in nucleotides 6-11, such that the attenuating mutation in the signal of termination of the gene M (T? C) is in nucleotide 4200, where these nucleotides are presented in the sense of the positive-strand antigenomic message.

6. A vaccine characterized in that it contains a measles virus, attenuated, isolated, recombinantly generated, according to claim 1 and a physiologically acceptable carrier.

7. The vaccine in accordance with rei indication 6, characterized in that it contains a measles virus in accordance with re-excitation 2 and a physiologically acceptable carrier.

8. A vaccine characterized in that it contains a sub-group B of the RSV attenuated, isolated, recombinantly generated, according to claim 3 and a physiologically acceptable carrier.

9. The vaccine according to claim 8, characterized in that it contains a subgroup B of the RSV according to claim 4 and a physiologically acceptable carrier.

10. The vaccine according to claim 8, characterized in that it contains a subgroup B of the RSV according to claim 5 and a physiologically acceptable carrier.

11. A method to immunize an individual, to induce protection against the measles virus, characterized in that it comprises administering to the individual the vaccine according to claim 6.

12. The method according to claim 11, characterized in that the vaccine is the vaccine of the rei indication 7.

13. A method for immunizing an individual, to induce protection against a subgroup B of RSV, characterized in that it comprises administering to the individual the vaccine according to claim 8.

14. The method of compliance with the re-excitation 13, characterized in that the vaccine is the vaccine of claim 9.

15. The method according to claim 13, characterized in that the vaccine is the vaccine according to claim 10.

16. A composition characterized in that it comprises a transcription vector that contains an isolated nucleic acid molecule, which encodes a genome or antigenome of a measles virus according to claim 1, together with at least one expression vector containing at least one isolated nucleic acid molecule, which encodes the proteins N, P and L of trans action, necessary for encapsidation, transcription and replication, whereby, with that expression, an attenuated infectious virus is produced.

17. The composition according to the rei indication 16, characterized in that the transcription vector comprises an isolated nucleic acid molecule, which encodes a measles virus according to claim 2.

18. A composition characterized in that it comprises a transcription vector, which contains an isolated nucleic acid molecule, encoding a genome or antigenome of a subgroup B of the RSV according to claim 3, together with at least one expression vector containing at least one a molecule of isolated nucleic acid encoding the trans-acting N, P, L and M2 proteins necessary for encapsidation, transcription and replication, whereby, with that expression, an attenuated, infectious, RSV subgroup B is produced.

19. The composition according to claim 18, characterized in that the transcription vector comprises an isolated nucleic acid molecule, which encodes a subgroup B of the RSV according to claim 4.

. The composition according to claim 18, characterized in that the transcription vector comprises an isolated nucleic acid molecule, which encodes a subgroup B of the RSV, according to claim 5.

21. A method for producing a measles virus, infectious, attenuated, characterized in that it comprises transforming or transfecting host cells with at least two vectors in accordance with rei indication 16 and cultivate the host cells under conditions that allow the coexpression of these vectors, in order to produce the measles virus, infectious, attenuated.

22. The method according to claim 21, characterized in that the virus is the measles virus according to claim 2.

23. A method for producing an infectious, attenuated RSV subgroup B, characterized in that it comprises transforming or transfecting host cells with at least the two vectors according to claim 18 and 'culturing the host cells under conditions allowing the co-expression of these vectors, in order to produce subgroup B of the RSV, infectious, attenuated.

24. The method according to claim 23, characterized in that the virus is subgroup B of the RSV, according to claim 4.

25. The method according to claim 23, characterized in that the virus is subgroup B of the RSV, according to claim 5.