DK44791A - Behandling af beskadiget knoglemarv - Google Patents

Behandling af beskadiget knoglemarv Download PDF

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Publication number
DK44791A
DK44791A DK044791A DK44791A DK44791A DK 44791 A DK44791 A DK 44791A DK 044791 A DK044791 A DK 044791A DK 44791 A DK44791 A DK 44791A DK 44791 A DK44791 A DK 44791A
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DK
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Prior art keywords
pharmaceutically acceptable
damage
aliphatic
substituted
bone marrow
Prior art date
Application number
DK044791A
Other languages
Danish (da)
English (en)
Other versions
DK44791D0 (da
Inventor
Richard F Borch
Therese K Schmalbach
Original Assignee
Univ Rochester
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rochester filed Critical Univ Rochester
Publication of DK44791D0 publication Critical patent/DK44791D0/da
Publication of DK44791A publication Critical patent/DK44791A/da

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Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/21—Esters, e.g. nitroglycerine, selenocyanates
    • A61K31/27—Esters, e.g. nitroglycerine, selenocyanates of carbamic or thiocarbamic acids, meprobamate, carbachol, neostigmine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P39/00—General protective or antinoxious agents
    • A61P39/02—Antidotes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P7/00—Drugs for disorders of the blood or the extracellular fluid

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  • Health & Medical Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Emergency Medicine (AREA)
  • Epidemiology (AREA)
  • Diabetes (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Hematology (AREA)
  • Toxicology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Polishing Bodies And Polishing Tools (AREA)
  • Magnetic Heads (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Materials For Medical Uses (AREA)
DK044791A 1988-09-12 1991-03-12 Behandling af beskadiget knoglemarv DK44791A (da)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US07/243,405 US4938949A (en) 1988-09-12 1988-09-12 Treatment of damaged bone marrow and dosage units therefor
PCT/US1989/003941 WO1990002550A1 (fr) 1988-09-12 1989-09-12 Traitement de la moelle osseuse endommagee, et unites de dosage pour un tel traitement

Publications (2)

Publication Number Publication Date
DK44791D0 DK44791D0 (da) 1991-03-12
DK44791A true DK44791A (da) 1991-05-10

Family

ID=22918655

Family Applications (1)

Application Number Title Priority Date Filing Date
DK044791A DK44791A (da) 1988-09-12 1991-03-12 Behandling af beskadiget knoglemarv

Country Status (9)

Country Link
US (1) US4938949A (fr)
EP (1) EP0433393B1 (fr)
JP (1) JPH04500676A (fr)
AT (1) ATE119771T1 (fr)
AU (1) AU623184B2 (fr)
DE (1) DE68921760D1 (fr)
DK (1) DK44791A (fr)
NZ (1) NZ230622A (fr)
WO (1) WO1990002550A1 (fr)

Families Citing this family (611)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5187193A (en) * 1988-09-12 1993-02-16 University Of Rochester Method for stimulating transplanted bone marrow cells
WO1991005571A1 (fr) * 1989-10-10 1991-05-02 University Of Rochester Procede de fabrication des facteurs de croissance des cellules de la moelle osseuse
CA2113990A1 (fr) * 1991-07-26 1993-02-18 Frederick L. Moolten Traitement anticancereux utilisant des cellules malignes
US5240914A (en) * 1992-02-03 1993-08-31 Adolph Schwimmer Method and compositions for inhibiting tumor cell metabolism
US6514949B1 (en) 1994-07-11 2003-02-04 University Of Virginia Patent Foundation Method compositions for treating the inflammatory response
US6448235B1 (en) 1994-07-11 2002-09-10 University Of Virginia Patent Foundation Method for treating restenosis with A2A adenosine receptor agonists
US7135584B2 (en) * 1995-08-07 2006-11-14 Wake Forest University Lipid analogs for treating viral infections
US5962437A (en) * 1994-08-29 1999-10-05 Wake Forest University Lipid analogs for treating viral infections
US5807874A (en) * 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5767142A (en) * 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5616575A (en) * 1995-12-04 1997-04-01 Regents Of The University Of Minnesota Bioactive tricyclic ibogaine analogs
US5932553A (en) * 1996-07-18 1999-08-03 The Regents Of The University Of California Illudin analogs useful as antitumor agents
US5723632A (en) 1996-08-08 1998-03-03 Mgi Pharma, Inc. Total synthesis of antitumor acylfulvenes
US5922761A (en) * 1996-09-06 1999-07-13 Medinox, Inc. Methods for in vivo reduction of iron levels and compositions useful therefor
CZ102499A3 (cs) * 1996-09-23 1999-09-15 Rutgers, The State University Of New Jersey Heterocyklické sloučeniny a farmaceutický prostředek
US5916903A (en) * 1997-02-28 1999-06-29 Synapse Pahrmaceuticals International, Inc. Method for reducing the effects of antineoplastic disease treatment
US5866558A (en) * 1997-05-08 1999-02-02 Regents Of The University Of Minnesota 6-alkynyl steroids
US6486214B1 (en) 1997-09-10 2002-11-26 Rutgers, The State University Of New Jersey Polyanhydride linkers for production of drug polymers and drug polymer compositions produced thereby
US6468519B1 (en) * 1997-09-10 2002-10-22 Rutgers, The State University Of New Jersey Polyanhydrides with biologically active degradation products
US6140328A (en) 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
CA2282461C (fr) * 1997-12-29 2004-04-20 John D. Buynak Derives d'acide penicillanique 2.beta.-substitue-6-alkylidene utilises comme inhibiteurs de la beta-lactamase
US6245808B1 (en) 1998-11-05 2001-06-12 Parker Hughes Institute Oxy-vanadium (IV) complexes having spermicidal activity
US6051603A (en) 1998-01-20 2000-04-18 Wayne Hughes Institute Vanadium (IV) metallocene complexes having sperm motility inhibiting activity
US6432941B1 (en) * 1998-01-20 2002-08-13 Parker Hughes Institute Vanadium compounds for treating cancer
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6025328A (en) 1998-02-20 2000-02-15 The Regents Of The University Of California Antitumor agents
US7141603B2 (en) * 1999-02-19 2006-11-28 The Regents Of The University California Antitumor agents
US6117878A (en) * 1998-02-24 2000-09-12 University Of Virginia 8-phenyl- or 8-cycloalkyl xanthine antagonists of A2B human adenosine receptors
US6355678B1 (en) 1998-06-29 2002-03-12 Parker Hughes Institute Inhibitors of the EGF-receptor tyrosine kinase and methods for their use
US6800649B1 (en) * 1998-06-30 2004-10-05 Parker Hughes Institute Method for inhibiting c-jun expression using JAK-3 inhibitors
US6323190B1 (en) 1998-07-31 2001-11-27 The Univeristy Of Georgia Research Foundation, Inc. Estrogen mimetics lacking reproductive tract effects
US6232297B1 (en) 1999-02-01 2001-05-15 University Of Virginia Patent Foundation Methods and compositions for treating inflammatory response
US7427606B2 (en) * 1999-02-01 2008-09-23 University Of Virginia Patent Foundation Method to reduce inflammatory response in transplanted tissue
US7378400B2 (en) * 1999-02-01 2008-05-27 University Of Virginia Patent Foundation Method to reduce an inflammatory response from arthritis
US6166003A (en) * 1999-02-17 2000-12-26 Lkt Laboratories, Inc. Heterocyclic compounds for cancer chemoprevention
WO2000048622A2 (fr) 1999-02-22 2000-08-24 University Of Iowa Research Foundation Methode permettant l'inhibition de reactions inflammatoires
US6080747A (en) * 1999-03-05 2000-06-27 Hughes Institute JAK-3 inhibitors for treating allergic disorders
DK1159279T3 (da) 1999-03-09 2003-02-17 Upjohn Co 4-Oxo-4,7-dihydro-thieno[2,3-b]pyridin-5-carboxamider som antivirale midler
US7064114B2 (en) * 1999-03-19 2006-06-20 Parker Hughes Institute Gel-microemulsion formulations
US6306897B1 (en) 1999-03-19 2001-10-23 Parker Hughes Institute Calanolides for inhibiting BTK
US6258820B1 (en) 1999-03-19 2001-07-10 Parker Hughes Institute Synthesis and anti-tumor activity of 6,7-dialkoxy-4-phenylamino-quinazolines
US6407091B1 (en) * 1999-04-15 2002-06-18 Research Corporation Technologies, Inc. β-lactamase inhibiting compounds
US6930101B1 (en) 1999-05-17 2005-08-16 The Regents Of The University Of California Thiazolopyrimidines useful as TNFα inhibitors
US6322771B1 (en) 1999-06-18 2001-11-27 University Of Virginia Patent Foundation Induction of pharmacological stress with adenosine receptor agonists
AU5630800A (en) 1999-06-22 2001-01-09 Arno F Spatola Antimicrobial agents
US6946458B2 (en) 1999-07-22 2005-09-20 University Of South Florida N-thiolated beta-lactams: novel antibacterial agents for methicillin-resistant Staphylococcus aureus
US7151100B1 (en) * 1999-07-23 2006-12-19 The Regents Of The University Of California Indole compounds useful for the treatment of cancer
US6852685B1 (en) 1999-08-17 2005-02-08 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof to promote neuronal cell differentiation
US6903068B1 (en) 1999-08-17 2005-06-07 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof for inducing cytokines
US7119064B2 (en) * 1999-08-17 2006-10-10 Board Of Regents, The University Of Texas System Use of colostrinin, constituent peptides thereof, and analogs thereof as modulators of intracellular signaling molecules
WO2001012650A2 (fr) * 1999-08-17 2001-02-22 The University Of Texas System Utilisation de la colostrinine, de ses peptides constitutifs, et de ses analogues comme regulateurs du stress oxydatif
MY125942A (en) 1999-09-07 2006-09-29 Upjohn Co Aminoalkoxy carbazoles for the treatment of cns diseases
US7026469B2 (en) * 2000-10-19 2006-04-11 Wake Forest University School Of Medicine Compositions and methods of double-targeting virus infections and cancer cells
US6670341B1 (en) 1999-10-28 2003-12-30 Wake Forest University Health Sciences Compositions and methods for double-targeting virus infections and targeting cancer cells
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU1608801A (en) 1999-11-15 2001-05-30 Parker Hughes Institute Diamino platinum (ii) antitumor complexes
US6649654B1 (en) * 1999-11-23 2003-11-18 The Regents Of The University Of California Methods for identifying and using IKK inhibitors
US6589992B2 (en) 1999-11-30 2003-07-08 Parker Hughes Institute Inhibiting collagen-induced platelet aggregation
US6685928B2 (en) 1999-12-07 2004-02-03 Rutgers, The State University Of New Jersey Therapeutic compositions and methods
US20040038948A1 (en) 1999-12-07 2004-02-26 Uhrich Kathryn E. Therapeutic compositions and methods
EP1252181B1 (fr) * 2000-01-20 2006-01-18 Regents Of The University Of Minnesota Polypeptides possedant une activite therapeutique
US6413958B2 (en) 2000-03-21 2002-07-02 Pharmacia & Upjohn Company 4-hydroxy-1,8-naphthyridine-3-carboxamides as antiviral agents
CN1398258A (zh) 2000-03-21 2003-02-19 法玛西雅厄普约翰美国公司 用作抗病毒剂的4－羟基噌啉－3－甲酰胺化合物
EP1265895A1 (fr) 2000-03-21 2002-12-18 PHARMACIA & UPJOHN COMPANY 4-oxo-1,4-dihydro 1,8]naphtyridine-3-carboxamides en tant qu'agents antiviraux
US6682892B2 (en) 2000-07-13 2004-01-27 Pharmacia & Upjohn Company Method for treating herpes viruses
US20040152672A1 (en) * 2000-08-09 2004-08-05 Carson Dennis A. Indole compounds useful for the treatment of cancer
US6696441B1 (en) 2000-08-11 2004-02-24 The Regents Of The University Of California Inhibition of p53-induced stress response
US6951847B2 (en) * 2000-09-29 2005-10-04 Regents Of The University Of Minnesota Methods of treating fungal infections using lupeol
AU2001294959A1 (en) * 2000-09-29 2002-04-08 Robert M. Carlson Triterpenes having antibacterial activity
CA2424013A1 (fr) 2000-09-29 2002-04-04 Regents Of The University Of Minnesota Triterpenes ayant une activite fongicide dirigee contre les levures
US7309696B2 (en) 2000-10-19 2007-12-18 Wake Forest University Compositions and methods for targeting cancer cells
US6958359B1 (en) * 2000-11-15 2005-10-25 Parker Hughes Institute Vanadium compounds as anti-angiogenic agents
US6642221B1 (en) 2000-11-15 2003-11-04 Parker Hughes Institute Vanadium compounds as anti-proliferative agents
US6878388B1 (en) 2000-11-15 2005-04-12 Parker Hughes Institute Vanadium compounds for treating proliferative cell disorders
AU2002249885A1 (en) 2000-11-17 2002-08-12 Adolor Corporation Delta agonist analgesics
US20040034045A1 (en) * 2000-11-29 2004-02-19 Parker Hughes Institute Inhibitors of thrombin induced platelet aggregation
US7250172B2 (en) * 2001-01-31 2007-07-31 University Of Iowa Research Foundation Vaccine and compositions for the prevention and treatment of neisserial infections
US7261901B2 (en) * 2001-01-31 2007-08-28 University Of Iowa Research Foundation Vaccine and compositions for the prevention and treatment of neisserial infections
US6703524B2 (en) 2001-02-20 2004-03-09 Lkt Laboratories, Inc. Organoselenium compounds for cancer chemoprevention
US7232829B2 (en) * 2001-04-06 2007-06-19 Regents Of The University Of Minnesota Therapeutic compounds and methods
GB0111872D0 (en) * 2001-05-15 2001-07-04 Northwick Park Inst For Medica Therapeutic agents and methods
EP1397326A2 (fr) * 2001-05-29 2004-03-17 Koninklijke Philips Electronics N.V. Liaison metal-ceramique
US7601846B2 (en) * 2001-06-26 2009-10-13 The Regents Of The University Of California Compounds having activity as inhibitors of apoptosis
US20030232794A1 (en) * 2001-06-26 2003-12-18 Cottam Howard B. Use of STAT-6 inhibitors as therapeutic agents
JP2005502687A (ja) * 2001-07-24 2005-01-27 アラムクス エルエルシー β−ラクタマーゼ阻害剤としての７−アルキリデン−３−置換型−３−セフェム−４−カルボキシラート
US6753414B2 (en) * 2001-08-07 2004-06-22 University Of Iowa Research Foundation, Inc. Process for preparing saponin compounds
MXPA04001203A (es) 2001-08-08 2004-05-20 Pharmacia & Upjhon Company 1-h-pirido[4,3-b] indoles terapeuticos.
US20030171377A1 (en) * 2001-08-29 2003-09-11 Bigge Christopher Franklin Antidiabetic agents
WO2003020728A1 (fr) 2001-08-30 2003-03-13 Pharmacia & Upjohn Company Agents antiviraux a base de 4-thioxo-4,7-dihydro-thieno[2,3-b]pyridine-5-carbothioamides
WO2003021959A1 (fr) * 2001-08-31 2003-03-13 Thomson Licensing Sa Compteur de sequences destine a un flux audio continu
US6887868B2 (en) * 2001-09-21 2005-05-03 Pharmacia & Upjohn Company Therapeutic 5-HT ligand compounds
EP1430017A2 (fr) 2001-09-26 2004-06-23 Theravance, Inc. Composes phenoliques substitues utiles pour l'anesthesie et la sedation
SG176313A1 (en) * 2001-10-01 2011-12-29 Univ Virginia Patent Found 2-propynyl adenosine analogs having a2a agonist activity and compositions thereof
WO2003031587A2 (fr) * 2001-10-09 2003-04-17 The Regents Of The University Of California Utilisation d'inhibiteurs de stat-6 comme agents therapeutiques
DE60238435D1 (de) * 2001-10-26 2011-01-05 Scripps Research Inst Gezielte thrombose durch gewebefaktor polypeptiden
EP1453812B1 (fr) * 2001-11-14 2008-08-20 Rutgers, The State University Agents cytotoxiques
KR20050044491A (ko) 2001-11-14 2005-05-12 루트거스, 더 스테이트 유니버시티 가용화된 토포이소머라제 독
AU2002357762A1 (en) * 2001-11-23 2003-06-10 Theodore James Anastasion Improved synthesis of polyanhyrides
US7030141B2 (en) * 2001-11-29 2006-04-18 Christopher Franklin Bigge Inhibitors of factor Xa and other serine proteases involved in the coagulation cascade
JP2005530685A (ja) * 2002-01-25 2005-10-13 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 選択的鎮痛剤
US20080026984A1 (en) * 2002-02-04 2008-01-31 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
US7968605B2 (en) * 2002-02-04 2011-06-28 ALFAMA—Investigação e Desenvolvimento de Produtos Farmacêuticos, Lda. Methods for treating inflammatory disease by administering aldehydes and derivatives thereof
BR0307420A (pt) * 2002-02-04 2004-12-21 Werner Haas Compostos, composições farmacêuticas e métodos para impedir e/ou tratar doença em mamìfero
US20060057179A1 (en) 2002-02-07 2006-03-16 Giroux Karen J Therapeutic polyesters and polyamides
WO2003072053A2 (fr) 2002-02-22 2003-09-04 The Curators Of The University Of Missouri Composes pour le traitement de la surcharge en cuivre
US20050032713A1 (en) * 2002-03-27 2005-02-10 Wurtman Richard J. Platelet-activating factor antagonists as analgesic, anti-inflammatory, uterine contraction inhibiting, and anti-tumor agents
AU2003224874A1 (en) * 2002-04-04 2003-10-27 Alamx, L.L.C. INHIBITORS OF SERINE AND METALLO-ss-LACTAMASES
MXPA04010560A (es) * 2002-04-25 2005-08-15 Scripps Research Inst Tratamiento y prevencion de condiciones pulmonares.
US7026472B2 (en) * 2002-05-06 2006-04-11 University Of South Florida Methods for preventing and treating cancer using N-thiolated β-lactam compounds and analogs thereof
US20040156799A1 (en) * 2002-06-04 2004-08-12 Zigang Dong Cancer treatment method and compositions
UA79293C2 (en) * 2002-07-03 2007-06-11 Univ Wayne State 4-(7'-halo-2-quino (xa-) linyloxy)phenoxy propionic acid derivatives as antineoplastic agents
WO2004004640A2 (fr) * 2002-07-05 2004-01-15 Tetragrammaton Inc. Procedes, compositions et trousses destines a traiter un tissu excitable endommage
AU2003265406A1 (en) * 2002-08-09 2004-02-25 Edmond J. Lavoie Nitro and amino substituted topoisomerase agents
WO2004024679A1 (fr) * 2002-09-11 2004-03-25 Warner-Lambert Company Llc Inhibiteurs de facteur xa et autres serine proteases intervenant dans la cascade de coagulation
US7211599B2 (en) * 2002-09-19 2007-05-01 The Regents Of The University Of California Use of etodolac to treat hyperplasia
EP2447278B1 (fr) 2002-10-10 2015-04-08 Cornell Research Foundation, Inc. Nouvelles protéines immunogènes de Leptospira
US20060183106A1 (en) * 2002-10-18 2006-08-17 Adam Siddiqui-Jain Processes for identifying quadruplex-targeted antiviral molecules
EP1567551A4 (fr) * 2002-10-22 2008-03-12 Univ Texas Colostrinine et peptides de celle-ci utilises en tant que modulateurs de molecules de signalisation intracellulaire et inhibiteurs de l'apoptose
WO2004039362A2 (fr) * 2002-10-28 2004-05-13 Paraquest, Inc. Hypoestoxydes, derives et agonistes de ces derniers a utiliser dans le traitement et la prophylaxie d'hyperlipidemies
EP3299393A1 (fr) 2002-11-08 2018-03-28 Ablynx N.V. Anticorps à domaine unique dirigés contre le facteur alpha de la nécrose tumorale et leurs utilisations
EP1558650A2 (fr) 2002-11-08 2005-08-03 Ablynx N.V. Procede d'administration de polypeptides therapeutiques et polypeptides associes
GB2395432B (en) * 2002-11-20 2005-09-14 Northwick Park Inst For Medica Therapeutic delivery of carbon monoxide to extracorporeal and isolated organs
WO2004047800A2 (fr) * 2002-11-26 2004-06-10 Gilead Sciences, Inc. Procede de chargement de medicament dans des liposomes par gradient
WO2004053099A2 (fr) * 2002-12-10 2004-06-24 The Scripps Research Institute Methode de traitement de pharmacodependance et de criblage d'agents pharmaceutiques utiles pour ledit traitement
US8119854B2 (en) * 2002-12-10 2012-02-21 Pietro P. Sanna Role of proteoglycans in drug dependence
WO2004062583A2 (fr) * 2003-01-07 2004-07-29 University Of Iowa Research Foundation Vaccin et procede de prevention de la formation d'un film biologique
NZ540771A (en) 2003-01-10 2009-05-31 Ablynx Nv Recombinant VHH single domain antibody from camelidae against von willebrand factor (vWF) or against collagen
US20070207217A1 (en) * 2003-02-03 2007-09-06 Alfama - Investigacao E Desenvolvimento De Productos Farmaceuticos Lda Method for treating a mammal by administration of a compound having the ability to release CO
US20050079512A1 (en) * 2003-02-26 2005-04-14 Emerson Beverly M. Methods of modulating gene expression
WO2004087672A1 (fr) 2003-03-28 2004-10-14 Cornell Research Foundation, Inc. Compositions de substances analogues a la migrastatine et leurs utilisations
US7163948B2 (en) * 2003-04-07 2007-01-16 Cylene Pharmaceuticals, Inc. Heterocyclic substituted 1,4-dihydri-4ox9-1,8-naphthyridine analogs
KR100944600B1 (ko) * 2003-04-07 2010-02-25 사일린 파마슈티칼스, 인크 치환된 퀴노벤족사진 유사체
US7354916B2 (en) * 2003-04-07 2008-04-08 Cylene Pharmaceuticals Substituted quinobenzoxazine analogs
US7507727B2 (en) * 2003-04-07 2009-03-24 Cylene Pharmaceuticals, Inc. Substituted quinobenzoxazine analogs and methods of using thereof
US20040248880A1 (en) * 2003-04-25 2004-12-09 Jacobsen Eric Jon 1,2,3,4,5,6-Hexahydroazepino[4,5-B]indoles containing arylsulfones at the 9-position
CA2536357A1 (fr) * 2003-05-29 2004-12-23 The Scripps Research Institute Liberation ciblee sur des cellules exprimant la legumaine
WO2005009434A2 (fr) 2003-06-25 2005-02-03 The Burnham Institute Procedes et composes servant a provoquer l'apoptose dans des cellules cancereuses
WO2005003140A1 (fr) * 2003-07-02 2005-01-13 Pharmacia & Upjohn Company Llc 4-oxo-4,7-dihydrothieno[2,3-b]pyridine-5-carboxamides utilises comme agents antiviraux
PL1658291T3 (pl) 2003-08-25 2014-03-31 Dogwood Pharmaceuticals Inc Podstawione 8-heteroaryloksantyny
PL2520654T3 (pl) 2003-08-26 2017-08-31 The Regents Of The University Of Colorado, A Body Corporate Inhibitory aktywności proteazy serynowej i ich zastosowanie w sposobach i kompozycjach do leczenia zakażeń bakteryjnych
US9532994B2 (en) 2003-08-29 2017-01-03 The Regents Of The University Of California Agents and methods for enhancing bone formation by oxysterols in combination with bone morphogenic proteins
WO2005042699A2 (fr) * 2003-10-17 2005-05-12 Regents Of The University Of Minnesota Polypeptides modifies presentant une activite therapeutique et leurs methodes d'utilisation
DE60334645D1 (de) 2003-11-07 2010-12-02 Ablynx Nv Camelidae schwere ketten antikörper vhhs gegen epidermalen wachstumfaktor rezeptor (egfr) und ihre verwendung
CA2549160A1 (fr) * 2003-12-04 2005-06-23 The Scripps Research Institute Traitement et preventions de l'asthme
AU2004305075A1 (en) * 2003-12-19 2005-07-07 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies
NZ589967A (en) 2004-01-14 2012-07-27 Gilead Sciences Inc Lipid-based dispersions useful for drug delivery
WO2005072766A2 (fr) * 2004-01-27 2005-08-11 Boys Town National Research Hospital Peptides se liant aux proteines hsp90
US8841326B2 (en) 2004-02-12 2014-09-23 Stc.Unm Therapeutic curcumin derivatives
US20050187191A1 (en) * 2004-02-20 2005-08-25 Kucera Louis S. Methods and compositions for the treatment of respiratory syncytial virus
US20050187192A1 (en) * 2004-02-20 2005-08-25 Kucera Pharmaceutical Company Phospholipids for the treatment of infection by togaviruses, herpes viruses and coronaviruses
AU2005232526B2 (en) * 2004-02-24 2011-06-23 The Regents Of The University Of California Methods and materials for assessing prostate cancer therapies and compounds
ES2629682T3 (es) 2004-03-29 2017-08-14 University Of South Florida Tratamiento efectivo de tumores y cáncer con fosfato de triciribina
US8957056B2 (en) * 2004-05-25 2015-02-17 Sloan-Kettering Instiute For Cancer Research Migrastatin analogs in the treatment of cancer
EP1778712B1 (fr) * 2004-08-02 2013-01-30 University Of Virginia Patent Foundation Analogues de 2-propynyle adenosine comprenant des groupes 5'-ribose modifies presentant une activite agoniste a2a
WO2006023272A1 (fr) * 2004-08-02 2006-03-02 University Of Virginia Patent Foundation Analogues de 2-polycyclique propynyle adenosine presentant une activite agoniste de a2a
WO2006028618A1 (fr) * 2004-08-02 2006-03-16 University Of Virginia Patent Foundation Analogues d'adenosine de propynyle 2-polycyclique presentant des groupes 5'-ribose modifies presentant une activite agoniste de a2a
WO2006026380A2 (fr) * 2004-08-25 2006-03-09 University Of Iowa Research Foundation Inhibiteurs de la geranylgeranyl pyrophosphate synthase
US20080213345A1 (en) * 2004-09-13 2008-09-04 Gilead Sciences, Inc. Delivering Iron to an Animal
US7718680B2 (en) * 2004-09-23 2010-05-18 Burnham Institute For Medical Research Inhibition of lethal factor protease activity from anthrax toxin
CA2582766C (fr) * 2004-09-23 2014-07-22 Sloan-Kettering Institute For Cancer Research Analogues d'isomigrastatine utilises dans le traitement du cancer
AU2005293752A1 (en) * 2004-10-13 2006-04-20 Ablynx N.V. Single domain camelide anti-amyloid beta antibodies and polypeptides comprising the same for the treatment and diagnosis of degenarative neural diseases such as Alzheimer's disease
US8697674B2 (en) * 2004-12-29 2014-04-15 Naturon, Inc. Xanthurenic acid derivative pharmaceutical compositions and methods related thereto
WO2006086103A2 (fr) * 2005-01-10 2006-08-17 University Of Virginia Patent Foundation Synthese d'inhibiteurs de p90rsk
US7691364B2 (en) 2005-01-28 2010-04-06 Bezwada Biomedical, Llc Functionalized drugs and polymers derived therefrom
US7709517B2 (en) * 2005-05-13 2010-05-04 The Regents Of The University Of California Diarylhydantoin compounds
PL2444085T3 (pl) 2005-05-13 2015-07-31 Univ California Związki diarylohydantoinowe jako antagoniści receptora androgenów do leczenia raka
MX363423B (es) 2005-05-18 2019-03-22 Ablynx Nv Nanobodiestm (nanocuerpos) mejorados contra el factor alfa de necrosis del tumor.
EP2444424B1 (fr) 2005-05-20 2018-08-08 Ablynx N.V. Nano-corps améliorés (tm) pour le traitement des troubles liés à l'agrégation
US20070025910A1 (en) * 2005-07-29 2007-02-01 Norenberg Jeffrey P Anticancer therapy
ATE527998T1 (de) * 2005-08-03 2011-10-15 Univ California Illudin-analoga als krebsmittel
CA2620182A1 (fr) 2005-08-22 2007-03-01 Dennis A. Carson Agonistes tlr
CA2618970C (fr) 2005-08-29 2015-03-31 University Of Virginia Patent Foundation Analogues d'une lisofylline et procedes d'utilisation de ceux-ci
US8871764B2 (en) 2005-08-29 2014-10-28 University Of Virginia Patent Foundation Lisofylline analogs and methods for use
WO2007053794A2 (fr) 2005-10-21 2007-05-10 Bezwada Biomedical Llc Composés phénoliques fonctionnalisés et dispositifs absorbables fabriqués à partir desdits composés
US20090291437A1 (en) * 2005-11-02 2009-11-26 O'brien Sean Methods for targeting quadruplex sequences
WO2007064759A2 (fr) * 2005-11-29 2007-06-07 The Scripps Research Institute Inhibition de l'invasion des cellules tumorales, de la metastase et de l'angiogenese
US8007526B2 (en) 2005-12-01 2011-08-30 Bezwada Biomedical, Llc Difunctionalized aromatic compounds and polymers therefrom
WO2007078615A2 (fr) * 2005-12-15 2007-07-12 Cavit Sciences, Inc Procédés et compositions de traitement du cancer
US20070244057A1 (en) * 2006-01-20 2007-10-18 Henry Paulson Suppressing polyglutamine aggregation and toxicity
GB0601394D0 (en) 2006-01-24 2006-03-01 Hemocorm Ltd Therapeutic delivery of carbon monoxide
US7615649B2 (en) 2006-01-26 2009-11-10 Iowa State University Research Foundation, Inc, Synthesis of polycyclic procyanidins
WO2007120972A2 (fr) * 2006-02-10 2007-10-25 University Of Virginia Patent Foundation Procede permettant de traiter l'anemie a hematies falciformes
US20080009545A1 (en) * 2006-02-21 2008-01-10 The Ohio State University Research Foundation Anticancer agents
WO2007098281A2 (fr) 2006-02-27 2007-08-30 Regents Of The University Of California Composés oxystérols et voie
JP5503874B2 (ja) 2006-02-28 2014-05-28 ダート ニューロサイエンス （ケイマン） エルティーディー 治療化合物
CN101431996A (zh) * 2006-03-22 2009-05-13 加利福尼亚大学董事会 蛋白质异戊二烯基转移酶的抑制剂
EP2656842B1 (fr) 2006-03-27 2016-08-10 The Regents of The University of California Modulateur de récepteur androgène pour le traitement du cancer de la prostate et de maladies associées au récepteur androgène
CA2648139A1 (fr) 2006-03-29 2007-11-08 The Regents Of The University Of California Composes de diarylthiohydantoine et leur utilisation dans le traitement de troubles d'hyperproliferation
US8093235B2 (en) 2006-04-25 2012-01-10 Rutgers, The State University Of New Jersey Macrocyclic compounds which stabilize G-Quadruplex DNA and RNA
US8426568B2 (en) * 2006-05-22 2013-04-23 University Of Virginia Patent Foundation Rhamnose substituents of SL0101 and therapeutic uses thereof
US8846697B2 (en) 2006-05-31 2014-09-30 The Regents Of The University Of California Purine analogs
WO2007143081A2 (fr) * 2006-06-02 2007-12-13 The Ohio State University Research Foundation Agents thérapeutiques destinés au traitement de malignités lymphoïdes
US20110112086A1 (en) * 2006-06-08 2011-05-12 Cylene Pharmaceuticals, Inc. Pyridinone analogs
US20100305136A1 (en) * 2006-06-08 2010-12-02 Johnny Yasuo Nagasawa Quinolone analogs derivatized with sulfonic acid, sulfonate or sulfonamide
UA105164C2 (en) 2006-06-16 2014-04-25 Догвуд Фармасьютикалз, Инк Substituted 8-[6-amino-3-pyridyl]xanthines
US8188063B2 (en) * 2006-06-19 2012-05-29 University Of Virginia Patent Foundation Use of adenosine A2A modulators to treat spinal cord injury
EP2102144A4 (fr) 2006-09-13 2011-03-23 Univ Rutgers Agents actifs et oligomères et polymères de ceux-ci
WO2008036244A1 (fr) * 2006-09-18 2008-03-27 The Burham Institute For Medical Research Utilisation de cyclosporine a pour sensibiliser des cellules cancéreuses résistantes à des ligands de récepteur de mort
CA2666461A1 (fr) * 2006-10-10 2008-09-12 Burnham Institute For Medical Research Compositions neuroprotectrices et procedes correspondants
US8034829B2 (en) 2006-11-17 2011-10-11 Rexahn Pharmaceuticals, Inc. 5, 6, or 7-substituted-3-(hetero)arylisoquinolinamine derivatives and therapeutic use thereof
EP2086962A1 (fr) * 2006-11-29 2009-08-12 Pfizer Products Inc. 1- [ ( 4 -chlorophényl) amide 5-{[2-fluoro-4- (2-oxo-2h-pyridin-1-yl) -phényl]amide) d'acide (r) -5-méthyl-4, 5-dihydro- pyrazole-1, 5-dicarboxylique servant d'inhibiteur du facteur xa
CA2672965C (fr) 2006-12-19 2018-02-06 Ablynx N.V. Sequences d'acides amines dirigees contre une metalloproteinase de la famille adam et polypeptides les comprenant a des fins de traitement de maladies et troubles lies a adam
AU2007336242B2 (en) 2006-12-19 2012-08-30 Ablynx N.V. Amino acid sequences directed against GPCRs and polypeptides comprising the same for the treatment of GPCR-related diseases and disorders
JP2010518108A (ja) 2007-02-06 2010-05-27 ユニバーシティ オブ ルーイビル リサーチ ファウンデーション，インコーポレーテッド 治療化合物
PL2510946T3 (pl) 2007-02-07 2015-12-31 Univ California Koniugaty syntetycznych agonistów tlr i ich zastosowania
WO2008103818A1 (fr) * 2007-02-21 2008-08-28 University Of Louisville Research Foundation Compositions thérapeutiques à base de cotinine
CA2679301C (fr) 2007-02-28 2015-08-11 University Of Virginia Patent Foundation Analogues de lisofylline et procedes d'utilisation en matiere de protection des cellules beta pancreatiques, de traitement du diabete de type 1 et de traitement des maladies inflammatoires et auto-immunes
WO2008138001A2 (fr) 2007-05-08 2008-11-13 University Of Louisville Research Foundation Peptides synthétiques et mimétiques peptidiques
EP2173352B1 (fr) * 2007-07-12 2016-09-07 University of South Florida Inhibiteurs de akt/pkb à activité antitumorale
EP2185568A4 (fr) 2007-08-02 2010-08-11 Trustees Rutgers The State Uni Composés thérapeutiques
US20090087497A1 (en) * 2007-08-16 2009-04-02 Burnham Institute For Medical Research Compositions and methods for treating symptoms of aging
CN101820764B (zh) 2007-08-27 2014-06-04 海利空医疗公司 治疗用异噁唑化合物
US8217134B2 (en) 2007-08-30 2012-07-10 Bezwada Biomedical, Llc Controlled release of biologically active compounds
US8048980B2 (en) 2007-09-17 2011-11-01 Bezwada Biomedical, Llc Hydrolysable linkers and cross-linkers for absorbable polymers
MX2010003685A (es) * 2007-10-05 2010-06-02 Cylene Pharmaceuticals Inc Analogos de quinolona y metodos relacionados con los mismos.
US9115061B2 (en) * 2007-10-19 2015-08-25 Burnham Institute For Medical Research Naphthalene-based inhibitors of anti-apoptotic proteins
WO2009055677A1 (fr) * 2007-10-24 2009-04-30 University Of South Florida Disulfures s-hétérosubstitués antibactériens
UY31432A1 (es) 2007-10-26 2009-05-29 Compuestos de diarilhidantoina
US7951832B2 (en) * 2007-10-31 2011-05-31 Burnham Institute For Medical Research Pyrazole derivatives as kinase inhibitors
JP2011505357A (ja) 2007-12-03 2011-02-24 ザ リージェンツ オブ ザ ユニバーシティー オブ カリフォルニア ヘッジホッグシグナル伝達、骨誘導、抗脂肪生成、及びｗｎｔシグナル伝達を活性するためのオキシステロール
US8058259B2 (en) * 2007-12-20 2011-11-15 University Of Virginia Patent Foundation Substituted 4-{3-[6-amino-9-(3,4-dihydroxy-tetrahydro-furan-2-yl)-9H-purin-2-yl]-prop-2-ynyl}-piperidine-1-carboxylic acid esters as A2AR agonists
KR20100137449A (ko) * 2008-02-07 2010-12-30 더 리전트 오브 더 유니버시티 오브 캘리포니아 Ｔｌｒ７ 활성화제를 사용한 방광 질환의 치료
WO2009108716A2 (fr) 2008-02-27 2009-09-03 University Of Louisville Research Foundation Peptides synthétiques
WO2009114539A2 (fr) * 2008-03-10 2009-09-17 University Of Louisville Research Foundation Traitements neuroprotecteurs à base de peptide de liaison de l'intégrine et de l'angiopoïétine-1
WO2009114921A1 (fr) * 2008-03-17 2009-09-24 Dmitrienko Gary I INHIBITEURS DE β-LACTAMASES DE CLASSE B ET DE CLASSE D
WO2009146112A1 (fr) * 2008-04-02 2009-12-03 University Of Virginia Patent Foundation Compositions et procédés pour inhiber la sphingosine kinase
EP2947097A1 (fr) 2008-04-07 2015-11-25 Ablynx N.V. Séquences d'acides aminés dirigées contre les voies Notch et leurs utilisations
JP6034023B2 (ja) 2008-05-16 2016-11-30 アブリンクス エン．ヴェー． Ｃｘｃｒ４及び他のｇｐｃｒに指向性を有するアミノ酸配列及びそれを含む化合物
US9872867B2 (en) * 2008-06-06 2018-01-23 Tanya Kuritz Methods and compositions for modulation of innate immunity
EP2299809B1 (fr) 2008-06-17 2018-10-17 Ben Gurion University Of The Negev R&D Authority Composés de cyclohexylidène-éthylidène-octahydro-indène substitués
US8673910B2 (en) * 2008-06-30 2014-03-18 H. Lee Moffitt Cancer Center And Research Institute Proteasome inhibitors for selectively inducing apoptosis in cancer cells
US7947717B2 (en) * 2008-07-18 2011-05-24 Burnham Institute For Medical Research Inhibitors of lethal factor protease
US9125821B2 (en) 2008-07-28 2015-09-08 The Regents Of The University Of California Nanodrug targeting protein geranylgeranylation
WO2010014054A1 (fr) * 2008-07-28 2010-02-04 The Regents Of The University Of California Inhibiteurs de prényltransférases de protéine
MX2011001486A (es) 2008-08-05 2011-05-02 Univ South Florida El uso de mediadores inflamatorios en el tratamiento del deterioro cognotivo.
US9132168B2 (en) 2008-08-05 2015-09-15 University Of South Florida Methods of treating cognitive impairment
AU2009279400A1 (en) * 2008-08-08 2010-02-11 University Of Florida Research Foundation, Inc. Lipid compounds for supression of tumorigenesis
US9801865B2 (en) 2008-09-24 2017-10-31 The United States Of America As Represented By The Department Of Veteran Affairs Materials and methods for diagnosis, prevention and/or treatment of stress disorders and conditions associated with abeta peptide aggregation
US8124654B2 (en) * 2008-11-11 2012-02-28 Immune Modulation, Inc. Derivatives of hypoestoxide and related compounds
TW201038578A (en) 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
WO2010088924A1 (fr) 2009-02-06 2010-08-12 Telormedix Sa Compositions pharmaceutiques comprenant des imidazoquinolines (amines) et des dérivés de celles-ci appropriés pour une administration locale
US8729088B2 (en) * 2009-02-11 2014-05-20 The Regents Of The University Of California Toll-like receptor modulators and treatment of diseases
EP2403856B1 (fr) 2009-03-06 2012-12-19 Rutgers, The State University of New Jersey Dérivés de méthylènedioxybenzo [i]phénanthridine pour traiter le cancer
CA2755975A1 (fr) 2009-03-20 2010-09-23 University Of Iowa Research Foundation Bisphosphonates prenyles en tant qu'agents antituberculeux
CA2758191C (fr) 2009-04-10 2015-06-30 Ablynx N.V. Sequences d'acides amines ameliorees directement contre il-6r et polypeptides comprenant celles-ci pour le traitement de maladies et de troubles associes a il-6r
CA2758491A1 (fr) 2009-04-15 2010-10-21 Sanford-Burnham Medical Research Institute Inhibiteurs de proteines anti-apoptotiques a base de naphtalene
US8487131B2 (en) 2009-04-15 2013-07-16 Sanford-Burnham Medical Research Institute Optically pure apogossypol derivative as pan-active inhibitor of anti-apoptotic B-cell lymphoma/leukemia-2 (BCL-2)
US20120108823A1 (en) 2009-04-22 2012-05-03 The Ohio State University Research Foundation Anti-francisella agents
US8906965B2 (en) 2009-05-11 2014-12-09 The University Of Tennessee Research Foundation Anti-inflammatory quinic acid derivatives for radioprotection/radiomitigation
EP2430016B1 (fr) 2009-05-13 2020-04-01 University Of Virginia Patent Foundation Inhibiteurs de leucémie inv(16)
US8263762B2 (en) 2009-06-30 2012-09-11 Dogwood Pharmaceuticals, Inc. Alkoxy-carbonyl-amino-alkynyl-adenosine compounds and derivatives thereof as A2AR agonists
WO2011005871A1 (fr) 2009-07-07 2011-01-13 Pgxhealth, Llc 8-[6-carbonylamino-3-pyridyle] xanthines substituées en tant qu’antagonistes de l’adénosine a2b
SG177557A1 (en) 2009-07-09 2012-02-28 Cbt Dev Ltd Combined preparation for use as a medicament
KR20120085738A (ko) 2009-07-31 2012-08-01 바이오크리스트파마슈티컬즈,인코포레이티드 야누스 키나제 억제제로서의 피롤로 ［1,2-ｂ］ 피리다진 유도체
WO2011019995A2 (fr) 2009-08-14 2011-02-17 Hecht Sidney M Synthèse et identification de nouveaux inhibiteurs spécifiques de la rsk
TW201111385A (en) 2009-08-27 2011-04-01 Biocryst Pharm Inc Heterocyclic compounds as janus kinase inhibitors
US8642088B2 (en) 2009-09-04 2014-02-04 Wisconsin Alumni Research Foundation Tannin-chitosan composites
US8993535B2 (en) 2009-09-04 2015-03-31 Merck Sharp & Dohme Corp. Modulators of cell cycle checkpoints and their use in combination with checkpoint kinase inhibitors
EA201270347A1 (ru) * 2009-10-08 2012-11-30 Санфорд-Бернхам Медикал Ресерч Инститъют Производные апогоссиполона в качестве противоопухолевых агентов
CA2780145A1 (fr) 2009-11-05 2011-05-12 Rutgers, The State University Of New Jersey Composes therapeutiques
WO2011069075A2 (fr) 2009-12-04 2011-06-09 Grant Jon E Traitement de troubles du contrôle des impulsions au moyen d'inhibiteurs de la catéchol-o-méthyltransférase
EP2516444A2 (fr) 2009-12-23 2012-10-31 Biocryst Pharmaceuticals, Inc. Composés hétérocycliques comme inhibiteurs de la janus kinase
US9096544B2 (en) 2009-12-23 2015-08-04 Wayne State University Therapeutic compounds
EA201792046A1 (ru) 2010-02-16 2018-05-31 Арагон Фармасьютикалс, Инк. Модуляторы рецептора андрогенов и их применение
CA2828114A1 (fr) 2010-02-26 2011-09-01 Gary Igor DMITRIENKO Derives de la cephalosporine utiles comme inhibiteurs de la .beta.-lactamase et leurs compositions et procedes d'utilisation
WO2011123416A1 (fr) 2010-03-29 2011-10-06 Surmodics, Inc. Formulation injectable pour l'administration de médicaments
EP2552885A1 (fr) 2010-04-02 2013-02-06 TSRL, Inc. Inhibiteurs de la neuraminidase
WO2011127344A2 (fr) 2010-04-08 2011-10-13 University Of Virginia Patent Foundation Méthode de détection et de traitement d'une diarrhée infectieuse ou inflammatoire
WO2011130740A2 (fr) 2010-04-16 2011-10-20 H. Lee Moffitt Cancer Center And Research Institute, Inc. Urées à base de pyridylthiazole utilisées comme inhibiteurs des protéines kinases associées à rho (rock), et leurs procédés d'utilisation
WO2011133696A2 (fr) 2010-04-20 2011-10-27 Regents Of The University Of Minnesota Méthodes de lutte contre l'athérosclérose
WO2011150356A1 (fr) 2010-05-28 2011-12-01 Biocryst Pharmaceuticals, Inc. Composés hétérocycliques en tant qu'inhibiteurs de janus kinase
WO2011156626A1 (fr) 2010-06-09 2011-12-15 Rutgers, The State University Of New Jersey Agents antimicrobiens
CA2803890A1 (fr) 2010-06-25 2011-12-29 Rutgers, The State University Of New Jersey Agents antimicrobiens
US8741317B2 (en) 2010-08-19 2014-06-03 Rutgers, The State University Of New Jersey Slow-degrading polymers comprising salicylic acid for undelayed and sustained drug delivery
WO2012027494A1 (fr) 2010-08-24 2012-03-01 Regents Of The University Of Minnesota Réactifs bispécifiques de ciblage
US20120083473A1 (en) 2010-09-21 2012-04-05 Johanna Holldack Treatment of conditions by toll-like receptor modulators
WO2012061120A1 (fr) 2010-10-25 2012-05-10 Regents Of The University Of Minnesota Composition thérapeutique pour le traitement du glioblastome
WO2012058665A1 (fr) 2010-10-29 2012-05-03 University Of Connecticut Compositions et procédés pour modulation et détection de réponses immunitaires et inflammatoires
EP2635274B1 (fr) 2010-11-01 2017-12-06 The Ohio State University Research Foundation Dérivés de célécoxib anti-staphylocoque
EP2646553A4 (fr) 2010-11-12 2015-01-07 Santaris Pharma As Compositions et procédés pour le traitement de troubles dépendant des récepteurs androgènes y compris les cancers
US8309768B2 (en) 2010-11-29 2012-11-13 The Ohio State University Research Foundation FTY720-derived anticancer agents
US8546397B2 (en) 2010-12-20 2013-10-01 The Ohio State University Research Foundation DNA methylation inhibitors
US8933119B2 (en) 2011-01-03 2015-01-13 The William M. Yarbrough Foundation Method for treating phytophotodermatitis
US9962361B2 (en) 2011-01-03 2018-05-08 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US11279674B2 (en) 2011-01-03 2022-03-22 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US10647668B2 (en) 2011-01-03 2020-05-12 The William M. Yarbrough Foundation Isothiocyanate functional surfactant and associated method of use
US10640464B2 (en) 2011-01-03 2020-05-05 The William M. Yarbrough Foundation Use of isothiocyanate functional surfactants as Nrf2 inducers to treat epidermolysis bullosa simplex and related diseases
US10273205B2 (en) 2011-01-03 2019-04-30 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating isothiocyanate functional surfactants and associated methods for treating biofilms
US10308599B2 (en) 2011-01-03 2019-06-04 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US11407713B2 (en) 2011-01-03 2022-08-09 The William M. Yarbrough Foundation Isothiocyanate functional surfactants, formulations incorporating the same, and associated methods of use
US8865765B2 (en) 2011-01-12 2014-10-21 The William M. Yarbrough Foundation Method for treating eczema
WO2012109108A1 (fr) 2011-02-07 2012-08-16 Biogen Idec Ma Inc. Agents modulant s1p
US9532969B2 (en) 2011-02-08 2017-01-03 The William M. Yarbrough Foundation Method for treating psoriasis
EP2683837A2 (fr) 2011-03-07 2014-01-15 University Of Louisville Research Foundation, Inc. Marqueur prédictif de l'efficacité thérapeutique de l'inhibiteur dnmt1, et procédés d'utilisation dudit marqueur
US9616064B2 (en) 2011-03-30 2017-04-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. Rho kinase inhibitors and methods of use
KR20140027211A (ko) 2011-04-04 2014-03-06 유니버시티 오브 아이오와 리써치 파운데이션 백신 면역원성의 개선 방법
WO2012139015A1 (fr) 2011-04-06 2012-10-11 Rutgers, The State University Of New Jersey Polymères et procédés pour le traitement de la douleur
WO2012145520A2 (fr) 2011-04-19 2012-10-26 Alfama, Inc. Molécules libérant du monoxyde de carbone et utilisations de celles-ci
WO2012145678A1 (fr) 2011-04-20 2012-10-26 Regents Of The University Of Minnesota Composés parthénolides anticancéreux et anti-inflammatoire
WO2012177770A1 (fr) 2011-06-20 2012-12-27 Rutgers, The State University Of New Jersey Inhibiteurs bipartites de l'arn polymérase bactérienne
US9133230B2 (en) 2011-06-21 2015-09-15 The United States Of America As Represented By The Department Of Veterans Affairs Hydrazone derivatives having potent antitumor activity toward multi-drug resistant tumor cells
EP2729483A1 (fr) 2011-07-08 2014-05-14 Regents Of The University Of Minnesota Analogues du glutathion et leurs utilisations
ES2628634T3 (es) 2011-07-21 2017-08-03 Alfama, Inc. Moléculas liberadoras de monóxido de carbono-rutenio y usos de las mismas
AU2012287103B2 (en) 2011-07-22 2017-03-30 University Of Louisville Research Foundation, Inc. Anti-biofilm compounds
MX359664B (es) 2011-07-29 2018-10-05 Univ Colorado Regents Tratamiento de cáncer de mama.
WO2013025936A1 (fr) 2011-08-18 2013-02-21 Cornell University Détection et traitement d'une maladie métastatique
WO2013028866A1 (fr) 2011-08-24 2013-02-28 Regents Of The University Of Minnesota Composés et méthodes thérapeutiques
US9034336B2 (en) 2011-08-30 2015-05-19 Regents Of The University Of Minnesota Immunomodulators and immunomodulator conjugates
EP2750508A4 (fr) 2011-08-30 2015-01-14 Univ Wayne State Composés et procédés thérapeutiques
CA2846676C (fr) 2011-09-08 2020-06-23 Western University Of Health Sciences Liposomes cibles en therapie cancereuse
JP2014527083A (ja) 2011-09-15 2014-10-09 アリゾナ ボード オブ リージェンツ， ア ボディー コーポレイト オブ ザ ステート オブ アリゾナ， アクティング フォー アンド オン ビハーフ オブ アリゾナ ステート ユニバーシティー 治療用化合物
DK2773325T3 (en) * 2011-11-04 2019-01-14 Enceladus Pharmaceuticals B V LIPOSOMAL CORTICOSTEROIDS FOR TREATMENT OF INFLAMMATORY DISORDERS BY HUMANS
WO2013101719A2 (fr) * 2011-12-27 2013-07-04 Northeast Ohio Medical University Composés et analogues d'amooranine et procédés d'utilisation associés
US9517994B2 (en) 2012-01-05 2016-12-13 Rutgers, The State University Of New Jersey Antibacterial agents: phloroglucinol derivatives
CA2862999A1 (fr) 2012-01-11 2013-07-18 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona Acting For And On Behalf Of Arizona State University Fragments d'anticorps bispecifiques pour proteines associees a une maladie neurologique, et procedes d'utilisation
WO2013106756A2 (fr) 2012-01-13 2013-07-18 Rutgers, The State University Of New Jersey Agents antimicrobiens
US9333242B2 (en) 2012-01-19 2016-05-10 Hybrid Medical, Llc Topical therapeutic formulations
US9296728B2 (en) 2012-01-20 2016-03-29 Regents Of The University Of Minnesota Therapeutic compounds
US9488664B2 (en) 2012-01-25 2016-11-08 Sbi Pharmaceuticals Co., Ltd. Diagnostic agent for tumor
US20130195752A1 (en) 2012-02-01 2013-08-01 Regents Of The University Of Minnesota Functionalized nanoparticles and methods of use thereof
CA2863427C (fr) 2012-02-01 2022-07-12 The Governors Of The University Of Alberta Utilisation de pdgfr-alpha en tant que marqueur de diagnostic pour le cancer de la thyroide papillaire
US9839634B2 (en) 2012-02-06 2017-12-12 Rutgers, The State University Of New Jersey Antibacterial agents: combination of a rifamycin and a switch region inhibitor
WO2013119946A1 (fr) 2012-02-08 2013-08-15 Of Virginia Patent Foundation University Inhibiteurs de la kinase sphingosine avec base à longue chaîne
WO2013131089A2 (fr) 2012-03-02 2013-09-06 The Board Of Trustees Of The University Of Illinois Activité anticancéreuse puissante par activation d'un composé double
AU2013230985B2 (en) 2012-03-06 2016-05-12 The Board Of Trustees Of The University Of Illinois Procaspase combination therapy for glioblastoma
WO2013142712A1 (fr) 2012-03-21 2013-09-26 Rutgers, The State University Of New Jersey Agents anti-microbiens
WO2013142812A1 (fr) 2012-03-22 2013-09-26 Rutgers, The State University Of New Jersey Agents antibactériens : dérivés de myxopyronine à chaîne latérale fluorée
JP2015512404A (ja) 2012-03-26 2015-04-27 ユニバーシティー オブ アイオワ リサーチ ファウンデーション シュワインフルチン類似体
US9272016B2 (en) 2012-04-20 2016-03-01 University Of Iowa Research Foundation Methods to enhance RNAi oligonucleotide delivery to respiratory epithelial cells
US9717742B2 (en) 2012-05-07 2017-08-01 The Regents Of The University Of California Oxysterol analogue OXY133 induces osteogenesis and hedgehog signaling and inhibits adipogenesis
EP2852390A1 (fr) 2012-05-21 2015-04-01 Chemi Nutra Inc. Compositions et procédés pour l'augmentation de la force et de la masse musculaire
WO2013177458A1 (fr) 2012-05-23 2013-11-28 Chemi Nutra Compositions destinées à augmenter la force, la masse musculaire et la masse corporelle maigre
EP2854834A4 (fr) 2012-05-30 2016-05-18 Biostrategies LC Lectines végétales utilisées en tant qu'excipient de substances médicamenteuses associées dans des cellules animales et humaines
WO2013188882A1 (fr) 2012-06-15 2013-12-19 Rutgers, The State University Of New Jersey Macromolécules pour le traitement de l'athérosclérose
US9175010B2 (en) 2012-06-18 2015-11-03 Dart Neuroscience (Cayman) Ltd. Therapeutic thiophene-, furan-, and pyridine-fused azolopyrimidin-5-(6H)-ones
US9315495B2 (en) 2012-06-19 2016-04-19 Rutgers, The State University Of New Jersey Antibacterial agents: aryl myxopyronin derivatives
EP2863910B1 (fr) 2012-06-20 2020-03-11 University Of Virginia Patent Foundation Compositions et procédés pour réguler l'homéostasie du glucose et l'action de l'insuline
WO2014008407A1 (fr) 2012-07-05 2014-01-09 University Of Iowa Research Foundation Bisphosphonates thérapeutiques
CA2876021C (fr) 2012-07-10 2020-09-22 Xpd Holdings, Llc Composes antioxydants multifonctionnels stabilises et procedes d'utilisation
RU2696278C2 (ru) 2012-07-18 2019-08-01 Юниверсити Оф Нотр Дам Дю Лак 5,5-гетероароматические противоинфекционные соединения
WO2014018671A1 (fr) 2012-07-24 2014-01-30 Regents Of The University Of Minnesota Composés thérapeutiques pour le traitement du cancer
US8865772B2 (en) 2012-07-26 2014-10-21 The William M. Yarbrough Foundation Method for treating skin cancer
US10434082B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Isothiocyanate functional compounds augmented with secondary antineoplastic medicaments and associated methods for treating neoplasms
US9949943B2 (en) 2012-07-26 2018-04-24 The William M. Yarbrough Foundation Method for treating neurodegenerative diseases
US10335387B2 (en) 2012-07-26 2019-07-02 The William M. Yarbrough Foundation Method for treating infectious diseases with isothiocyanate functional compounds
US10434081B2 (en) 2012-07-26 2019-10-08 The William M. Yarbrough Foundation Inhibitors of macrophage migration inhibitory factor
US9839621B2 (en) 2012-07-26 2017-12-12 The William M. Yarbrough Foundation Method for treating bladder cancer
US10080734B2 (en) 2012-07-26 2018-09-25 The William M. Yarbrough Foundation Method for treating autism and other neurodevelopmental disorders
US10441561B2 (en) 2012-07-26 2019-10-15 The William M. Yanbrough Foundation Method for treating benign prostatic hyperplasia (BPH), prostatitis, and prostate cancer
MY171486A (en) 2012-07-27 2019-10-15 Biogen Ma Inc Atx modulating agents
NZ703992A (en) 2012-08-01 2018-04-27 Lewis And Clark Pharmaceuticals Inc N-alkyl 2-(disubstituted)alkynyladenosine-5’-uronamides as a2a agonists
AU2013296187B2 (en) 2012-08-03 2016-09-29 The Board Of Trustees Of The University Of Illinois Enzyme-activating compounds and compositions
ES2660287T3 (es) 2012-08-06 2018-03-21 Biogen Ma Inc. Compuestos que son agentes moduladores de s1p y/o agentes moduladores de atx
EP2879673B1 (fr) 2012-08-06 2018-07-25 Biogen MA Inc. Dérivés de la naphthaline substitué 1,5,6 en tant que modulateurs du récepteur sphingosine 1 phosphate (S1P) et/ou autotaxin (ATX) pour le traitement de maladies d'inflammation et d'auto-immunité
WO2014028025A1 (fr) 2012-08-16 2014-02-20 University Of Southern California Compositions et procédés pour le traitement de la dystrophie myotonique de type 1
DK2888010T3 (da) 2012-08-22 2021-06-28 Univ Cornell Fremgangsmåder til at hæmme fascin
US9737493B2 (en) 2012-09-07 2017-08-22 University Of Louisville Research Foundation, Inc. Compositions and methods for modulating DNMT1 inhibitor activity
WO2014043252A2 (fr) 2012-09-11 2014-03-20 Rutgers, The State University Of New Jersey Hydroxypyridones, hydroxypyrimidinones et hydroxypyridazinones thérapeutiques
WO2014041546A1 (fr) 2012-09-13 2014-03-20 Ben-Gurion University Of The Negev Research And Development Authority Agents de diagnostic à sensibilité/spécificité améliorées
WO2014043510A1 (fr) 2012-09-13 2014-03-20 Chang Gung Memorial Hospital Nouvelle composition pharmaceutique et ses utilisations
NZ705815A (en) 2012-09-26 2018-08-31 Aragon Pharmaceuticals Inc Anti-androgens for the treatment of non-metastatic castrate-resistant prostate cancer
EP2906260B1 (fr) 2012-10-09 2019-06-26 Case Western Reserve University Nanoparticules de virus de plante en forme de bâtonnet en tant que plates-formes d'agent d'imagerie
US9957214B2 (en) 2012-10-10 2018-05-01 Arizona Board Of Regents On Behalf Of Arizona State University Multifunctional radical quenchers
US20140120057A1 (en) 2012-10-25 2014-05-01 Rutgers, The State University Of New Jersey Polymers and methods thereof for wound healing
WO2014066840A1 (fr) 2012-10-26 2014-05-01 Regents Of The University Of Minnesota Inhibiteurs d'aurora kinase
WO2014070774A1 (fr) 2012-10-29 2014-05-08 Southern Methodist University Procédés de génération de composés de carbapénem résistants à la bêta-lactamase
BR112015010570B8 (pt) 2012-11-08 2021-04-20 Univ Rutgers agentes microbianos, composto e seu uso e composição farmacêutica
US9701638B2 (en) 2012-11-09 2017-07-11 Rutgers, The State University Of New Jersey Therapeutic hydroxyquinolones
MX2015005949A (es) 2012-11-16 2015-09-08 Biocryst Pharm Inc Nucleosidos que contienen aza-azucar antiviral.
WO2014078857A1 (fr) 2012-11-19 2014-05-22 Regents Of The University Of Minnesota Dérivés d'ergoline en tant que modulateurs d'un récepteur de la dopamine
US9850206B2 (en) 2012-11-20 2017-12-26 Biogen Ma Inc. S1P and/or ATX modulating agents
EP2922821B1 (fr) 2012-11-20 2019-07-31 Biogen MA Inc. Agents de modulation de s1p et/ou atx
US9522131B2 (en) 2013-01-11 2016-12-20 Wisconsin Alumni Research Foundation Tannin-containing gastrointestinal formulations and methods of use
JOP20200097A1 (ar) 2013-01-15 2017-06-16 Aragon Pharmaceuticals Inc معدل مستقبل أندروجين واستخداماته
EP2951148A4 (fr) 2013-01-29 2016-09-21 Biogen Ma Inc Agents modulateurs de s1p
US9981043B2 (en) 2013-02-08 2018-05-29 Regents Of The University Of Minnesota Analgesic conjugates
KR20150119188A (ko) 2013-02-15 2015-10-23 리젠츠 오브 더 유니버시티 오브 미네소타 입자 기능화
US9776975B2 (en) 2013-03-05 2017-10-03 University Of Notre Dame Du Lac Quinazolinone antibiotics
BR112015022202A2 (pt) 2013-03-14 2017-07-18 Dart Neuroscience Cayman Ltd compostos substituídos de naftiridina e quinolina como inibidores da mao
SG11201504709PA (en) 2013-03-14 2015-07-30 Dart Neuroscience Llc Substituted pyridine and pyrazine compounds as pde4 inhibitors
WO2014152725A1 (fr) 2013-03-15 2014-09-25 Biogen Idec Ma Inc. Modulateurs de s1p et/ou de l'atx
WO2014143672A1 (fr) 2013-03-15 2014-09-18 Biogen Idec Ma Inc. Composés macrocycliques en tant qu'inhibiteurs de irak4 pour le traitement de maladies inflammatoires
MX368669B (es) 2013-03-15 2019-10-10 Rexahn Pharmaceuticals Inc Procedimiento para la preparación de 4-amino-1-((1s,4r,5s)-2-fluor o-4,5-dihidroxi-3-hidroximetil-ciclopent-2-enil)-1h-pirimidin-2-o na.
MX2015012428A (es) 2013-03-15 2016-01-12 Genentech Inc Tratamiento contra enfermedades mediadas th2 por inhibicion de bromodominios.
US9387250B2 (en) 2013-03-15 2016-07-12 Rutgers, The State University Of New Jersey Therapeutic compositions for bone repair
AU2014259672A1 (en) 2013-05-02 2015-12-03 The Regents Of The University Of California Bone-selective osteogenic oxysterol-bone targeting agents
WO2014182620A1 (fr) 2013-05-06 2014-11-13 Kaohsiung Chang Gung Memorial Hospital Composition pharmaceutique et utilisations de celle-ci
WO2014194055A1 (fr) 2013-05-29 2014-12-04 Rutgers, The State University Of New Jersey Poly(anhydride-esters) à base d'antioxydants
WO2014205194A1 (fr) 2013-06-22 2014-12-24 Nitor Therapeutics Compositions et méthodes de potentialisation de la réponse immunitaire pour le traitement des maladies infectieuses et du cancer
US10682415B2 (en) 2013-07-22 2020-06-16 Wisconsin Alumni Research Foundation Thermogel formulation for combination drug delivery
CA2920100A1 (fr) 2013-08-01 2015-02-05 Regents Of The University Of Minnesota Procede d'administration de medicament
CN104341504B (zh) 2013-08-06 2017-10-24 百奥泰生物科技(广州)有限公司 双特异性抗体
EP3030241A4 (fr) 2013-08-06 2019-06-19 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteurs de la tyrosine kinase ack1/tnk2
WO2015038966A1 (fr) 2013-09-12 2015-03-19 Regents Of The University Of Minnesota Systèmes d'administration semi-solide
WO2015057863A1 (fr) 2013-10-15 2015-04-23 Regents Of The University Of Minnesota Réactifs triorthogonaux pour la conjugaison de protéines mixtes
CN112353791A (zh) 2013-11-11 2021-02-12 夸利蒂赫布丘蒂克斯公司 卡瓦衍生的治疗性化合物及其使用方法
US9387199B2 (en) 2013-11-12 2016-07-12 University Of Virginia Patent Foundation Compositions and methods for treating clostridium infection and preventing recurrence of infection
US9339482B2 (en) 2013-11-22 2016-05-17 Regents Of The University Of Minnesota Methods to treat dysregulated blood glucose disorders
US9315523B2 (en) 2013-12-06 2016-04-19 Rutgers, The State University Of New Jersey Cyclic dinucleosides
WO2015109318A2 (fr) 2014-01-17 2015-07-23 Arizona Board Of Regents, A Body Corporate Of The State Of Arizona, Acting For And On Behalf Of Arizona State University Méthodes thérapeutiques
EP3102193B1 (fr) 2014-02-06 2023-01-11 Rutgers, The State University of New Jersey Agents antibactériens : n(alpha)-aroyl-n-aryl-phénylalaninamides
WO2015123654A1 (fr) 2014-02-17 2015-08-20 The Cleveland Clinic Foundation Nanoparticules amine-passivées pour le traitement et l'imagerie du cancer
DK3107902T3 (da) 2014-02-20 2021-05-03 Cornell Univ Cornell Center For Technology Enterprise & Commercialization Cctec Forbindelser og fremgangsmåder til at hæmme fascin
US10189874B2 (en) 2014-02-26 2019-01-29 Arizona Board Of Regents On Behalf Of Arizona State University DNA gridiron compositions and methods
WO2015130973A1 (fr) 2014-02-26 2015-09-03 Arizona Board Of Regents On Behalf Of Arizona State University Composés thérapeutiques
US10272055B2 (en) 2014-03-06 2019-04-30 Regents Of The University Of Minnesota Therapeutic compounds and methods
AU2015226855C1 (en) 2014-03-07 2021-02-11 Biocryst Pharmaceuticals, Inc. Human plasma kallikrein inhibitors
US10197575B2 (en) 2014-03-31 2019-02-05 H. Lee Moffitt Cancer Center And Research Institute, Inc. Stabilized peptoid-peptide hybrids and uses thereof
CA2946112C (fr) 2014-04-18 2020-11-24 The Governors Of The University Of Alberta Therapie ciblee pour restaurer le transport de l'iode radioactif pour traiter le cancer de la thyroide
RU2659070C9 (ru) 2014-04-23 2018-08-24 Дарт Нейросайенс (Кайман) Лтд. ЗАМЕЩЕННЫЕ [1,2,4]ТРИАЗОЛО[1,5-a]ПИРИМИДИН-7-ИЛЬНЫЕ СОЕДИНЕНИЯ В КАЧЕСТВЕ ИНГИБИТОРОВ PDE2
EP3134406A1 (fr) 2014-04-24 2017-03-01 Dart Neuroscience (Cayman) Ltd Composés de 2,4,5,6-tétrahydropyrrolo[3,4-c]pyrazole et 4,5,6,7-tétrahydro-2 h-pyrazolo [4,3-c]pyridine utilisés comme inhibiteurs de glyt1
US9556113B2 (en) 2014-04-29 2017-01-31 The South Dakota Board Of Regents Combination uses of dichloroacetate and oxamate, and their prodrugs, for cancer treatment
US9987299B2 (en) 2014-05-05 2018-06-05 University Of Iowa Research Foundation Methods of improving RNAi in well-differentiated airway epithelia
EP3152206A1 (fr) 2014-06-06 2017-04-12 Biogen MA Inc. Agents de modulation d'atx
WO2015191742A1 (fr) 2014-06-13 2015-12-17 Rutgers, The State University Of New Jersey Procédé et intermédiaires pouvant être utilisés pour la préparation de polyanhydride-polyesters
US10138203B2 (en) 2014-06-16 2018-11-27 Rutgers, The State University Of New Jersey Antibacterial agents
NL2013661B1 (en) 2014-10-21 2016-10-05 Ablynx Nv KV1.3 Binding immunoglobulins.
US9737598B2 (en) 2014-06-30 2017-08-22 Regents Of The University Of Minnesota CD200 inhibitors and methods of use thereof
EP3912635A1 (fr) 2014-07-11 2021-11-24 Biostrategies LC Matériaux et procédés pour traiter des troubles associés aux enzymes sulfatases
AR101229A1 (es) 2014-07-18 2016-11-30 Biogen Ma Inc Agentes inhibidores de irak4
SG11201700978SA (en) * 2014-08-19 2017-03-30 Univ Okayama Nat Univ Corp Method for enhancing immune cell function and method for assessing immune cell multifunctionality
AU2015304860B2 (en) 2014-08-19 2020-07-16 Hsiri Therapeutics, LLC Antibacterial sideromycins
WO2016037171A1 (fr) 2014-09-05 2016-03-10 The Cleveland Clinic Foundation Flavonoïdes inhibiteurs d'il-17a
US9630905B2 (en) 2014-09-08 2017-04-25 Rutgers, The State University Of New Jersey Amphiphilic macromolecules and methods of use thereof
US11135178B2 (en) 2014-09-11 2021-10-05 University Of Iowa Research Foundation Thymol and carvacol for use in medicine
US10328114B2 (en) 2014-10-28 2019-06-25 University Of Iowa Research Foundation Lung injury repair compositions and methods
US10239882B2 (en) 2014-11-05 2019-03-26 Dart Neuroscience (Cayman) Ltd. Substituted 5-methyl-[1,2,4]triazolo[1,5-a]pyrimidin-2-amine compounds as PDE2 inhibitors
TWI601712B (zh) 2014-11-05 2017-10-11 達特神經科學（開曼）有限責任公司 作為ｇｌｙｔ１抑制劑之經取代之氮雜環丁基化合物
CN115414480A (zh) * 2014-11-10 2022-12-02 德玛医药 结合放射用于治疗非小细胞肺癌和多形性胶质母细胞瘤的二去水卫矛醇
WO2016076929A1 (fr) 2014-11-13 2016-05-19 University Of Iowa Research Foundation Procédés pour générer des cellules épithéliales
MX2017006382A (es) 2014-11-17 2018-04-10 Cellectar Biosciences Inc Analogos de eter fosfolipidico como portadores de farmacos dirigidos a cancer.
ES2772348T3 (es) 2014-12-19 2020-07-07 Ablynx Nv Dímeros de Nanobody con uniones cisteína
CN107405388A (zh) 2015-01-08 2017-11-28 衣阿华大学研究基金会 用于体内关节软骨再生的方法
AU2016206491A1 (en) 2015-01-16 2017-08-31 University Of Iowa Research Foundation Methods to prevent or treat periodontitis or peri-implantitis
JP6770534B2 (ja) 2015-02-17 2020-10-21 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ 治療用化合物
JP6807337B2 (ja) 2015-02-17 2021-01-06 アリゾナ ボード オブ リージェンツ オン ビハーフ オブ アリゾナ ステート ユニバーシティ ミトコンドリア治療剤としてのフェノチアジン類似体
US10112917B2 (en) 2015-03-03 2018-10-30 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US10221143B2 (en) 2015-03-03 2019-03-05 Arizona Board Of Regents On Behalf Of Arizona State University Substituted anilines for treatment of animal diseases
CN108112235A (zh) 2015-03-06 2018-06-01 克利夫兰临床基金会 改变类固醇代谢以用于治疗类固醇依赖性疾病
US9926261B2 (en) 2015-03-10 2018-03-27 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
US9950993B2 (en) 2015-03-13 2018-04-24 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
JP6930918B6 (ja) 2015-04-10 2021-12-15 ラトガーズ， ザ ステイト ユニバーシティ オブ ニュー ジャージー コウジ酸ポリマー
EP3294316A4 (fr) 2015-05-06 2018-10-17 H. Lee Moffitt Cancer Center And Research Institute, Inc. Agents théarapeutiques et agents d'imagerie compagnons ciblant le mc1r
WO2016179587A1 (fr) 2015-05-07 2016-11-10 Kuality Herbceutics Llc Composés thérapeutiques et leurs méthodes utilisation
US20180125780A1 (en) 2015-05-15 2018-05-10 The Methodist Hospital System Implantable nanochannel delivery devices
WO2016187264A1 (fr) 2015-05-18 2016-11-24 The Arizona Board Of Regents On Behalf Of The University Of Arizona Amélioration de la prévention du cancer par de nouvelles mélanotrines
US10350207B2 (en) 2015-06-05 2019-07-16 The Board Of Trustees Of The University Of Illinois PAC-1 combination therapy
TW201710503A (zh) 2015-06-12 2017-03-16 長庚醫療財團法人林口長庚紀念醫院 新穎多核苷酸、載體、醫藥組成物以及其用途
WO2016205397A2 (fr) 2015-06-15 2016-12-22 Klibanov Alexander L Administration spécifique de cible d'agents thérapeutiques
WO2016205534A1 (fr) 2015-06-16 2016-12-22 Lazo John S Inhibiteurs de ptp4a3 pour le traitement du cancer
US9399039B1 (en) 2015-06-30 2016-07-26 University Of South Florida Inhibitors of the FKBP51 protein from a high-throughput drug screen and methods of use
US10814006B2 (en) 2015-07-14 2020-10-27 University Of Iowa Research Foundation Fluorescent prodrugs
EP3725332B1 (fr) 2015-07-16 2023-10-04 Case Western Reserve University Particules de phytovirus pour l'administration d'agents antimitotiques
US10729669B2 (en) 2015-07-28 2020-08-04 University Of Iowa Research Foundation Compositions and methods for treating cancer
US10336734B2 (en) 2015-08-02 2019-07-02 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibitors of ACK1/TNK2 tyrosine kinase
WO2017027883A1 (fr) 2015-08-13 2017-02-16 San Diego State University Research Foundation Atropisomérisme pour une sélectivité accrue des inhibiteurs de kinase
JP6639651B2 (ja) 2015-09-04 2020-02-05 ヤンセン ファーマシューティカ エヌ．ベー． 疼痛のための治療化合物及びその合成
PL4019022T3 (pl) 2015-10-01 2024-06-24 Biocryst Pharmaceuticals, Inc. Inhibitory ludzkiej kalikreiny osoczowej
US10738016B2 (en) 2015-10-13 2020-08-11 H. Lee Moffitt Cancer Center And Research Institute, Inc. BRD4-kinase inhibitors as cancer therapeutics
US20180296531A1 (en) 2015-10-20 2018-10-18 The Cleveland Clinic Foundation Stimulation of 11b-hsd2 expression to improve hormonal therapy of steroid-dependent disease
EP4410376A2 (fr) 2015-11-03 2024-08-07 Regents of the University of Minnesota Inhibiteurs de cd200 et leurs procédés d'utilisation
CA3005730A1 (fr) 2015-11-20 2017-05-26 Senhwa Biosciences, Inc. Polytherapie comprenant des analogues de la quinolone tetracyclique pour le traitement du cancer
US9957282B2 (en) 2015-12-14 2018-05-01 Senhwa Biosciences, Inc. Crystalline forms of quinolone analogs and their salts
US9980951B2 (en) 2015-12-17 2018-05-29 University Of Iowa Research Foundation Image guided therapy for cancer
TWI726969B (zh) 2016-01-11 2021-05-11 比利時商健生藥品公司 用作雄性激素受體拮抗劑之經取代之硫尿囊素衍生物
WO2017127430A1 (fr) 2016-01-20 2017-07-27 Biogen Ma Inc. Agents inhibiteurs d'irak4
TWI747873B (zh) 2016-02-01 2021-12-01 美商百歐克斯製藥公司 苯并吡唑化合物及其類似物
WO2017156527A1 (fr) 2016-03-11 2017-09-14 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteurs des kinases aurora et des janus kinases pour la prévention de la maladie du greffon contre l'hôte
EP3429996A4 (fr) 2016-03-16 2020-02-12 H. Lee Moffitt Cancer Center And Research Institute, Inc. Petites molécules dirigées contre le céréblon pour améliorer la fonction des lymphocytes t effecteurs
US11529340B2 (en) 2016-03-22 2022-12-20 Regents Of The University Of Minnesota Combination for treating pain
US10759740B2 (en) 2016-03-24 2020-09-01 Rutgers, The State University Of New Jersey Antibacterial agents
JP2019515025A (ja) 2016-04-04 2019-06-06 ラトガース ザ ステイト ユニバーシティー オブ ニュージャージー トポイソメラーゼ毒
US10551384B2 (en) 2016-04-07 2020-02-04 Rutgers, The State University Of New Jersey MTOR kinase mutations and methods of use thereof
DK3445838T3 (da) 2016-04-18 2023-05-30 Gene Pool Tech Inc Isolering af planteekstrakter
RU2018142711A (ru) 2016-05-04 2020-06-04 Х. Ли Моффитт Кэнсер Сентер Энд Рисёч Инститьют, Инк. Средство для целенаправленного воздействия на дельта-опиоидный рецептор для молекулярной визуализации и иммунотерапии рака
US11697851B2 (en) 2016-05-24 2023-07-11 The Regents Of The University Of California Early ovarian cancer detection diagnostic test based on mRNA isoforms
CN115192719B (zh) 2016-05-26 2024-03-01 匹兹堡大学联邦高等教育系统 用于治疗肺血管疾病的组合物和方法
US10899793B2 (en) 2016-05-27 2021-01-26 Regents Of The University Of Minnesota Melanocortin ligands and methods of use thereof
WO2017214296A1 (fr) 2016-06-07 2017-12-14 University Of Iowa Research Foundation Fragments de junctophiline-2 et leurs utilisations
MX2018015990A (es) 2016-06-20 2019-10-07 Univ Rutgers Compuestos terapeuticos.
EP3474879A4 (fr) 2016-06-24 2020-05-06 University of Iowa Research Foundation Compositions et procédés de traitement d'un mélanome
EP3490552B1 (fr) 2016-07-26 2022-11-23 University of Southern California Inhibition sélective de bromodomaine de bdf1 fongique
US20180037909A1 (en) 2016-08-04 2018-02-08 Chang Gung Memorial Hospital, Linkou Modified cancer cell lines and uses thereof
US11390605B2 (en) 2016-08-25 2022-07-19 Arizona Board Of Regents On Behalf Of Arizona State University Substituted pyrimidine compounds as multifunctional radical quenchers and their uses
JP7033139B2 (ja) 2016-08-31 2022-03-09 ダート・ニューロサイエンス・エルエルシー 障害の治療のためのヒドロキシノルケタミン誘導体
SG11201903348UA (en) 2016-10-17 2019-05-30 Genentech Inc Therapeutic compounds and methods of use thereof
US11124541B2 (en) 2016-10-18 2021-09-21 Regents Of The University Of Minnesota Chimeric melanocortin ligands and methods of use thereof
MA46642A (fr) 2016-10-31 2021-04-21 Biocryst Pharm Inc Promédicaments d'inhibiteurs de la kallicréine
US11071747B2 (en) 2016-11-29 2021-07-27 University Of Iowa Research Foundation Use of NAD precursors for breast enhancement
EP3554285A4 (fr) 2016-11-29 2021-01-20 University of Iowa Research Foundation Utilisation de précurseurs de nad pour améliorer la santé maternelle et/ou la santé de la descendance
US20180194824A1 (en) 2016-12-14 2018-07-12 University Of Iowa Research Foundation Musclin peptides and methods of use thereof
ES2970715T3 (es) 2016-12-22 2024-05-30 Prec Pharmaceuticals Inc Composiciones y métodos para inhibir la actividad de la arginasa
AR110590A1 (es) 2016-12-27 2019-04-10 Biogen Ma Inc Activador de nrf2
CA3047408A1 (fr) 2016-12-28 2018-07-05 Dart Neuroscience, Llc Composes pyrazolopyrimidinone substitues en tant qu'inhibiteurs de pde2
US10710957B2 (en) 2017-01-09 2020-07-14 University Of Central Florida Research Foundation, Inc. Motuporamine derivatives as antimicrobial agents and antibiotic enhancers against resistant gram-negative bacteria
US20180230105A1 (en) 2017-01-13 2018-08-16 Regents Of The University Of Minnesota Therapeutic compounds
WO2018136792A1 (fr) 2017-01-20 2018-07-26 The Regents Of The University Of California Inhibiteurs du domaine n-terminal du récepteur d'androgène
US10238655B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Dihydroindene and tetrahydronaphthalene compounds
US10231947B2 (en) 2017-01-23 2019-03-19 Arizona Board Of Regents On Behalf Of Arizona State University Isochroman compounds and methods of use thereof
US10238626B2 (en) 2017-01-23 2019-03-26 Arizona Board Of Regents On Behalf Of Arizona State University Therapeutic compounds
US11090289B2 (en) 2017-01-24 2021-08-17 University Of Virginia Patent Foundation Compositions and methods for blocking sodium channels
US20190389830A1 (en) 2017-01-30 2019-12-26 Biogen Ma Inc. Nrf2 activator
US20190389836A1 (en) 2017-01-30 2019-12-26 Biogen Ma Inc. Nrf2 activator
US11168095B2 (en) 2017-02-07 2021-11-09 Biogen Ma Inc. ASK1 inhibiting agents
US11260050B2 (en) 2017-02-16 2022-03-01 United States Government As Represented By The Department Of Veterans Affairs Combination of cotinine plus antioxidant for treatment-resistant depression and correction of astrocytes functional deficit induced by depression and other neuropathological
US11938114B2 (en) 2017-03-10 2024-03-26 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
EP3592736A1 (fr) 2017-03-10 2020-01-15 Rutgers, the State University of New Jersey Dérivés d'indole utilisés en tant qu'inhibiteurs de pompe d'efflux
US11180459B2 (en) 2017-03-10 2021-11-23 Rutgers, The State University Of New Jersey Bacterial efflux pump inhibitors
JOP20190233A1 (ar) 2017-04-14 2019-10-02 Biogen Ma Inc نظائر بنزوازيبين بوصفها عوامل مثبطة لتيروزين كيناز بروتون
US10294264B2 (en) 2017-04-21 2019-05-21 Warsaw Orthopedic, Inc. Oxysterol-therapeutic agent derivative for bone healing
WO2018209355A1 (fr) 2017-05-12 2018-11-15 Innovus Pharmaceuticals, Inc. Méthodes thérapeutiques et compositions associees
US10434106B2 (en) 2017-05-19 2019-10-08 Warsaw Orthopedic, Inc. Oxysterol-statin compounds for bone growth
EP3630115A1 (fr) 2017-05-22 2020-04-08 University Of Virginia Patent Foundation Compositions et méthodes de préparation et d'utilisation de découpleurs mitochondriaux
JP7281822B2 (ja) 2017-05-26 2023-05-26 ラトガーズ、ザ ステイト ユニバーシティ オブ ニュージャージー 細菌の排出ポンプ阻害剤
TW202413408A (zh) 2017-06-02 2024-04-01 比利時商艾伯林克斯公司 結合聚集蛋白聚糖之免疫球蛋白
JP2020521804A (ja) 2017-06-02 2020-07-27 メルク パテント ゲゼルシャフト ミット ベシュレンクテル ハフツングＭｅｒｃｋ Ｐａｔｅｎｔ Ｇｅｓｅｌｌｓｃｈａｆｔ ｍｉｔ ｂｅｓｃｈｒａｅｎｋｔｅｒ Ｈａｆｔｕｎｇ Ｍｍｐ１３結合免疫グロブリン
CN111032695B (zh) 2017-06-02 2024-06-25 默克专利股份有限公司 结合adamts的免疫球蛋白
MX2019014397A (es) 2017-06-02 2020-02-10 Merck Patent Gmbh Polipeptidos que enlazan adamts5, mmp13 y agrecano.
AR112027A1 (es) 2017-06-15 2019-09-11 Biocryst Pharm Inc Inhibidores de alk 2 quinasa que contienen imidazol
WO2018237241A1 (fr) 2017-06-22 2018-12-27 University Of Virginia Patent Foundation Médecine atomique activée par protons
EP3641776B1 (fr) 2017-06-23 2023-10-18 San Diego State University Research Foundation Atropisomérisme pour une sélectivité améliorée des inhibiteurs de kinase
WO2019005841A1 (fr) 2017-06-26 2019-01-03 Rutgers, The State University Of New Jersey Composés thérapeutiques et méthodes pour traiter une infection
JP7213863B2 (ja) 2017-07-12 2023-01-27 ダート・ニューロサイエンス・エルエルシー Ｐｄｅ７阻害剤としての置換ベンゾオキサゾール及びベンゾフラン化合物
CN107446050A (zh) 2017-08-11 2017-12-08 百奥泰生物科技(广州)有限公司 Trop2阳性疾病治疗的化合物及方法
CN111479805B (zh) 2017-08-29 2024-08-13 罗格斯新泽西州立大学 治疗性吲唑
EP3676380B1 (fr) 2017-08-30 2022-05-18 Arizona Board of Regents on behalf of Arizona State University Nanostructures arn et méthodes de fabrication et d'utilisation de nanostructures arn
AU2018345909A1 (en) 2017-10-06 2020-04-09 Blue Therapeutics, Inc. Methods of treating acute or chronic pain
JOP20200076A1 (ar) 2017-10-16 2020-04-30 Aragon Pharmaceuticals Inc مضادات أندروجين لعلاج سرطان البروستاتا غير النقيلي المقاوم للاستئصال
CA3116829A1 (fr) 2017-10-17 2019-04-25 The Methodist Hospital System Dispositifs d'administration
KR20200090771A (ko) 2017-11-17 2020-07-29 더 보오드 오브 트러스티스 오브 더 유니버시티 오브 일리노이즈 이중 mek 신호 전달 분해를 통한 암 치료
JP2021503481A (ja) 2017-11-17 2021-02-12 サイトジェル ファーマ リミテッド ライアビリティ カンパニー μオピオイド受容体のポリマーアゴニスト
WO2019104030A1 (fr) 2017-11-21 2019-05-31 Biogen Ma Inc. Dérivés de tétrahydronaphtalène utiles en tant qu'activateurs de nrf2
CN111655695A (zh) 2017-11-27 2020-09-11 达特神经科学有限公司 作为pde1抑制剂的取代的呋喃并嘧啶化合物
EP3716956B1 (fr) 2017-11-29 2024-06-26 The Cleveland Clinic Foundation Composés modulant tet2 antitumoraux
EP3716948B1 (fr) 2017-11-30 2023-11-22 Cytogel Pharma, LLC Nouvelles formulations pharmaceutiques analgésiques et leurs utilisations
WO2019112885A1 (fr) 2017-12-07 2019-06-13 The Cleveland Clinic Foundation Traitement d'une maladie résistant aux stéroïdes à l'aide d'une anthocyanine et d'un corticostéroïde
WO2019140140A1 (fr) 2018-01-10 2019-07-18 Arizona Board Of Regents On Behalf Of Arizona State University Robots doubles nanostructurés par de l'arn et leurs méthodes d'utilisation
US10738093B2 (en) 2018-01-25 2020-08-11 The Hong Kong University Of Science And Technology Discovery of cationic nonribosomal peptides as Gram-negative antibiotics through global genome mining
US11685723B2 (en) 2018-02-13 2023-06-27 Rutgers, The State University Of New Jersey Antibacterial agents: O-alkyl-deuterated pyronins
CA3088998A1 (fr) 2018-02-15 2019-09-06 Senhwa Biosciences, Inc. Analogues de quinolone, sels correspondants, compositions et procede d'utilisation
WO2019168921A1 (fr) 2018-02-27 2019-09-06 University Of Virginia Patent Foundation Inhibiteur de liposomes/parp ciblés par plectine dans le traitement du cancer
AU2019229188B2 (en) 2018-02-28 2023-06-29 Dart Neuroscience, Llc Substituted cyclohexyl compounds as NOP inhibitors
WO2019173507A1 (fr) 2018-03-06 2019-09-12 Rutgers, The State University Of New Jersey Agents antibactériens : phloroglucinols arylalkylcarboxamido
WO2019178267A2 (fr) 2018-03-13 2019-09-19 University Of Iowa Research Foundation Régénération inductive des voies respiratoires par modulation du facteur transcriptionnel de cellules souches myoépithéliales glandulaires
JP7453916B2 (ja) 2018-03-14 2024-03-21 バイオジェン・エムエイ・インコーポレイテッド Ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グリコピラノシダーゼ阻害剤
TW202010742A (zh) 2018-04-06 2020-03-16 美商百歐克斯製藥公司 取代的苯并呋喃、苯并吡咯、苯并噻吩及結構相關的補體抑制劑
AU2019256722A1 (en) 2018-04-20 2020-11-05 Virginia Tech Intellectual Properties, Inc. Imidazopyridines useful as mitochondrial uncouplers
WO2020036654A2 (fr) 2018-04-27 2020-02-20 Arizona Board Of Regents On Behalf Of Arizona State University Topologies moléculaires hautement nouées à partir d'acides nucléiques monocaténaires
ES2968222T3 (es) 2018-05-14 2024-05-08 Biogen Ma Inc Agentes inhibidores para la tirosina cinasa de Bruton
TW202035389A (zh) 2018-06-27 2020-10-01 美商百健Ｍａ公司 Ask1抑制劑
CN112469420A (zh) 2018-07-09 2021-03-09 台湾微脂体股份有限公司 减少关节内类固醇的并发症的方法
KR20210032430A (ko) 2018-07-11 2021-03-24 에이치 리 모피트 캔서 센터 앤드 리서어치 인스티튜트 아이엔씨 세레블론-기반 메커니즘에 대한 이량체 면역-조절 화합물
US10898460B1 (en) 2018-07-20 2021-01-26 University Of South Florida Leishmania inhibitors
WO2020028814A1 (fr) 2018-08-03 2020-02-06 H. Lee Moffitt Cancer Center And Research Institute, Inc. Inhibiteur allostérique de la kinase wee1
US11897898B2 (en) 2018-08-14 2024-02-13 Biogen Ma Inc. Pyridine macrocycle compounds as ASK1 inhibiting agents
BR112021002690A2 (pt) 2018-08-14 2021-05-11 Biogen Ma Inc. agentes inibidores de ask1
US11332499B2 (en) 2018-08-16 2022-05-17 Regents Of The University Of Minnesota Cyclic peptides and methods of use thereof
CN113056474A (zh) 2018-09-13 2021-06-29 米尼阿姆里塔治疗学有限责任公司 用于治疗纤维化、nash和nafld的方法中的雷公藤内酯及其前药
BR112021004739A2 (pt) 2018-09-19 2021-06-01 Biogen Ma Inc. inibidores de o-glicoproteína-2-acetamido-2-desoxi-3-d-glucopiranosidase
WO2020081514A1 (fr) 2018-10-15 2020-04-23 Biogen Ma Inc. Polymorphes cristallins d'inhibiteurs de la tyrosine kinase de bruton
CN112996531A (zh) 2018-10-17 2021-06-18 逊斯泰特生物科学有限责任公司 用于增强治疗效果的单一蛋白质包封的药剂
EP3877439A4 (fr) 2018-11-07 2022-08-10 Regents of the University of Minnesota Compositions analgésiques et anti-accoutumance pour le traitement de la douleur chronique et de la dépendance aux opioïdes
WO2020097433A1 (fr) 2018-11-09 2020-05-14 The University Of Rochester Méthodes et systèmes de traitement de cancer sur la base d'une prédiction de réponse à l'aide d'une technologie de diffusion de lumière
JP2022513114A (ja) 2018-11-26 2022-02-07 デナリ セラピューティクス インコーポレイテッド 脂質代謝調節不全の治療方法
WO2020117961A1 (fr) 2018-12-05 2020-06-11 Biogen Ma Inc. Inhibiteurs de morpholinyle, de pipérazinyle, d'oxazépanyle et de diazépanyle o-glycoprotéine-2-acétamido-2-désoxy-3-d-glucopyranosidase
CA3126156A1 (fr) 2019-01-14 2020-07-23 Regents Of The University Of Minnesota Ligands cd200ar pour immunotherapie anticancereuse
US20220106305A1 (en) 2019-02-04 2022-04-07 Biogen Ma Inc. Bicyclic ether o-glycoprotein-2-acetamido-2-deoxy-3-d-glucopyranosidase inhibitors
EP3935055A1 (fr) 2019-03-08 2022-01-12 Biogen MA Inc. Inhibiteurs d'azétidinyl 0-glyc0pr0téin-2-acétamid0-2-désoxy-3-d-gluc0pyran0sidase
WO2020225779A1 (fr) 2019-05-09 2020-11-12 Istituto Pasteur Italia - Fondazione Cenci Bolognetti Agonistes de rig-i pour le traitement du cancer et l'immunothérapie
EP3969124A1 (fr) 2019-05-15 2022-03-23 Biogen MA Inc. Agents inhibiteurs de la tyrosine kinase de bruton
US20220241214A1 (en) 2019-06-20 2022-08-04 University Of Iowa Research Foundation Nanoparticles comprising quinone w methides and compositions for use
WO2020263989A1 (fr) 2019-06-24 2020-12-30 University Of Iowa Research Foundation Inhibiteurs de jnk en tant qu'agents anticancéreux
CR20220092A (es) 2019-08-06 2022-06-03 Biocryst Pharm Inc Síntesis de un inhibidor de calicreína plasmática a escala de proceso
BR112022006739B1 (pt) 2019-10-10 2024-01-23 Cellectar Biosciences, Inc Conjugados fosfolipídio-flavagina e métodos de uso do mesmo para terapia direcionada a câncer
AU2020370281A1 (en) 2019-10-25 2022-05-26 Accent Therapeutics, Inc. METTL3 modulators
JP2023501949A (ja) 2019-10-29 2023-01-20 バイオジェン・エムエイ・インコーポレイテッド スピロ環ｏ－糖タンパク質－２－アセトアミド－２－デオキシ－３－ｄ－グルコピラノシダーゼ阻害剤
WO2021087112A1 (fr) 2019-10-30 2021-05-06 Biogen Ma Inc. Bi-hétérocycles condensés utilisés en tant qu'agents inhibiteurs de la tyrosine kinase de bruton
EP4051679A1 (fr) 2019-10-30 2022-09-07 Biogen MA Inc. Pyridazine ou pyrimidine condensée utilisée en tant qu'inhibiteurs de btk
EP4081514A1 (fr) 2019-12-23 2022-11-02 Biogen MA Inc. Inhibiteurs de la btk
US20230053688A1 (en) 2020-01-10 2023-02-23 Cornell University Methods to alter latency in ebv+ malignancies
CA3183957A1 (fr) 2020-05-18 2021-11-25 Salk Institute For Biological Studies Derives de chromen-4-one, tels que par exemple des flavones, destines a etre utilises en tant qu'inhibiteurs de ck2 pour le traitement de la neuro-inflammation
CN116056693A (zh) 2020-07-10 2023-05-02 长庚医疗财团法人林口长庚纪念医院 β-1肾上腺素受体拮抗剂用于制备减少表皮生长因子受体抑制剂诱导的上皮细胞损伤以及抑制癌细胞的组合物的用途
US11529335B2 (en) 2020-07-31 2022-12-20 University Of Iowa Research Foundation Compositions and methods for treating cancer
TW202220972A (zh) 2020-08-07 2022-06-01 美商百健Ｍａ公司 Ｂｔｋ抑制劑
CA3193736A1 (fr) 2020-09-02 2022-03-10 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Agents de degradation ciblant lzk et procedes d'utilisation
JP2023546549A (ja) 2020-10-14 2023-11-02 アクセント・セラピューティクス・インコーポレイテッド Ｍｅｔｔｌ３モジュレーター
WO2022150446A1 (fr) 2021-01-07 2022-07-14 Biogen Ma Inc. Inhibiteurs de tyk2
JP2024508426A (ja) 2021-02-22 2024-02-27 リージェンツ オブ ザ ユニバーシティ オブ ミネソタ 免疫調節物質及び免疫調節物質コンジュゲート
TWI796023B (zh) 2021-03-10 2023-03-11 長庚醫療財團法人 藥物組合物及其用途
WO2022212893A1 (fr) 2021-04-02 2022-10-06 Biogen Ma Inc. Méthodes de traitement combiné de la sclérose en plaques
KR20240004737A (ko) 2021-05-04 2024-01-11 리젠츠 오브 더 유니버시티 오브 미네소타 피임 화합물 및 방법
US20240287076A1 (en) 2021-05-05 2024-08-29 Biogen Ma Inc. Compounds for targeting degradation of bruton's tyrosine kinase
JP2024523558A (ja) 2021-06-22 2024-06-28 デイナ ファーバー キャンサー インスティチュート，インコーポレイテッド 脳腫瘍の治療における使用のためのｅｇｆｒの（１ｈ－ピロロ［２，３－ｂ］ピリジン－１－イル）ピリミジン－２－イル－アミノ－フェニル－アクリルアミド阻害剤
WO2022271951A1 (fr) 2021-06-23 2022-12-29 University Of Iowa Research Foundation Formulations à libération prolongée comprenant un modulateur sélectif du récepteur des androgènes
EP4366834A1 (fr) 2021-07-07 2024-05-15 Biogen MA Inc. Composés pour le ciblage de la dégradation de protéines irak4
EP4367113A1 (fr) 2021-07-07 2024-05-15 Biogen MA Inc. Composés pour le ciblage de la dégradation de protéines irak4
WO2023034808A1 (fr) 2021-09-01 2023-03-09 The United States Of America, As Represented By The Secretary, Department Of Health And Human Services Inhibiteurs de kinase de lignée mixte et procédés d'utilisation
WO2023081237A1 (fr) 2021-11-03 2023-05-11 Regents Of The University Of Minnesota Agonistes et antagonistes du récepteur de type toll et leurs utilisations
WO2023086521A1 (fr) 2021-11-10 2023-05-19 Biogen Ma Inc. Inhibiteurs de btk
WO2023086575A1 (fr) 2021-11-12 2023-05-19 Biogen Ma Inc. Inhibiteurs de btk
US20240200078A1 (en) 2021-11-18 2024-06-20 Cornell University Microrna-dependent mrna switches for tissue-specific mrna-based therapies
WO2023130022A2 (fr) 2021-12-29 2023-07-06 University Of Iowa Research Foundation Compositions d'arn de cystatine pour l'ingénierie tissulaire
WO2023220046A1 (fr) 2022-05-10 2023-11-16 Biogen Ma Inc. Inhibiteurs de tyk2
WO2023220049A1 (fr) 2022-05-10 2023-11-16 Biogen Ma Inc. Polymorphes cristallins de n-méthyl-n-((1s,3s)-3-méthyl-3-((6-(1-méthyl-1h-pyrazol-4-yl)pyrazolo[1,5-a]pyrazin-4-yl)oxy)cyclobutyl)acrylamide
WO2024006977A1 (fr) 2022-07-01 2024-01-04 University Of Southern California Ligands bitopiques du récepteur opioïde delta analgésique
WO2024006493A1 (fr) 2022-07-01 2024-01-04 Biogen Ma Inc. Inhibiteurs de tyk2
WO2024009283A1 (fr) 2022-07-07 2024-01-11 University Of Southern California Antagonistes at2 pour soulager la douleur non addictive
WO2024011214A1 (fr) 2022-07-08 2024-01-11 Actio Biosciences, Inc. Composés et méthodes thérapeutiques
WO2024100093A1 (fr) 2022-11-09 2024-05-16 Merck Patent Gmbh Agonistes du récepteur 7 de type toll utilisés en tant que stimulateurs immunitaires pour déclencher l'immunité antitumorale innée
WO2024112932A1 (fr) 2022-11-23 2024-05-30 Regents Of The University Of Minnesota Immunomodulateurs et conjugués immunomodulateurs
WO2024124023A2 (fr) 2022-12-07 2024-06-13 Rutgers, The State University Of New Jersey Inhibiteurs d'enzyme anhydrase carbonique et leurs procédés d'utilisation

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4148885A (en) * 1973-09-25 1979-04-10 Institut Merieux Immunostimulant medicine
US4594238A (en) * 1980-08-08 1986-06-10 Regents Of University Of Minnesota Inhibition of undesired effect of platinum compounds
US4645661A (en) * 1984-06-29 1987-02-24 St. Jude Children's Research Hospital Method for alleviating cisplatin-induced nephrotoxicity and dithiocarbamate compounds for effecting same

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DK44791D0 (da) 1991-03-12
WO1990002550A1 (fr) 1990-03-22
AU4335589A (en) 1990-04-02
US4938949A (en) 1990-07-03
JPH04500676A (ja) 1992-02-06
EP0433393A1 (fr) 1991-06-26
EP0433393B1 (fr) 1995-03-15
NZ230622A (en) 1991-09-25

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