PT2403856E - Derivados de metilendioxibenzo[i]fenantridina utilizados para tratar o cancro - Google Patents

Derivados de metilendioxibenzo[i]fenantridina utilizados para tratar o cancro

Info

Publication number
PT2403856E
PT2403856E PT107084725T PT10708472T PT2403856E PT 2403856 E PT2403856 E PT 2403856E PT 107084725 T PT107084725 T PT 107084725T PT 10708472 T PT10708472 T PT 10708472T PT 2403856 E PT2403856 E PT 2403856E
Authority
PT
Portugal
Prior art keywords
methylenedioxybenzo
treat cancer
derivatives used
phenanthridine derivatives
phenanthridine
Prior art date
Application number
PT107084725T
Other languages
English (en)
Inventor
Edmond J Lavoie
Wei Feng
Leroy F Liu
Original Assignee
Univ Rutgers
Univ New Jersey Med
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Univ Rutgers, Univ New Jersey Med filed Critical Univ Rutgers
Publication of PT2403856E publication Critical patent/PT2403856E/pt

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D491/00—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00
    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/04—Ortho-condensed systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4355—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having oxygen as a ring hetero atom
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Epidemiology (AREA)
  • Oncology (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
PT107084725T 2009-03-06 2010-03-05 Derivados de metilendioxibenzo[i]fenantridina utilizados para tratar o cancro PT2403856E (pt)

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
US15815609P 2009-03-06 2009-03-06

Publications (1)

Publication Number Publication Date
PT2403856E true PT2403856E (pt) 2013-03-25

Family

ID=42133486

Family Applications (1)

Application Number Title Priority Date Filing Date
PT107084725T PT2403856E (pt) 2009-03-06 2010-03-05 Derivados de metilendioxibenzo[i]fenantridina utilizados para tratar o cancro

Country Status (7)

Country Link
US (2) US9562051B2 (pt)
EP (1) EP2403856B1 (pt)
JP (1) JP5773888B2 (pt)
DK (1) DK2403856T3 (pt)
ES (1) ES2401563T3 (pt)
PT (1) PT2403856E (pt)
WO (1) WO2010102219A1 (pt)

Families Citing this family (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer
EP3442979A4 (en) 2016-04-04 2019-12-18 Rutgers, the State University of New Jersey topoisomerase poisons

Family Cites Families (49)

* Cited by examiner, † Cited by third party
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CH420044A (de) 1964-09-01 1967-03-15 Ciba Geigy Verwendung von neuen Azol-Derivaten als optische Aufheller für textile organische Materialien
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US3849561A (en) 1964-10-20 1974-11-19 S Naruto Anti-peptic ulcer substance from corydalis tubers
DE1670684A1 (de) 1966-04-01 1970-12-03 Hoechst Ag Verfahren zur Herstellung von basisch substituierten Bis-benzimidazol-derivaten
US3542782A (en) 1967-03-15 1970-11-24 Sandoz Ag 5,6-dihydro-8h-isoquino(1,2-b)quinazolines
JPS4942700A (pt) 1972-08-25 1974-04-22
US3912740A (en) 1974-02-28 1975-10-14 Us Health Method for the preparation of oxygenated benzo{8 c{9 phenanthridine compounds
PT73763B (fr) 1981-10-01 1983-10-26 Quatrum Empresa Nacional De Qu Procede pour la preparation de nouveaux epoxides d'alkaloides benzofenantridiniques et de compositions pharmaceutiques qui les contiennent
US4749708A (en) 1982-05-14 1988-06-07 Maroko Peter R Composition for improving circulatory performance
IE55519B1 (en) 1982-05-14 1990-10-10 Maroko Peter R Use of a protoberberine alkaloid and composition containing same
US4761417A (en) 1982-05-14 1988-08-02 Maroko Peter R Compounds, compositions and method of treatments for improving circulatory performance
US4980344A (en) 1982-05-14 1990-12-25 Maroko Peter R Compositions for improving circulatory performance
US5153178A (en) 1982-05-14 1992-10-06 Maroko Peter R Compositions and method of treatment for improving circulatory performance
JPS61130289A (ja) 1984-11-29 1986-06-18 Ss Pharmaceut Co Ltd １３−プロピルベルベリンの塩
FR2595356B1 (fr) 1986-03-05 1991-05-24 Pasteur Strasbourg Universite Derives des nitro ou aminobenzyltetrahydroisoquinoleines, procedes d'obtention, compositions pharmaceutiques les contenant, proprietes pharmacologiques et applications
US5244903A (en) 1987-03-31 1993-09-14 Research Triangle Institute Camptothecin analogs as potent inhibitors of topoisomerase I
SU1530628A1 (ru) 1987-11-20 1989-12-23 Ленинградский Технологический Институт Им.Ленсовета Тригидрохлорид 2-[2-фенил-5(6)-бензимидазолил]-N-(3-диметиламинопропил)-5(6)-бензимидазолкарбоксамида в качестве флуоресцентного красител дл исследовани ДНК
US4938949A (en) 1988-09-12 1990-07-03 University Of New York Treatment of damaged bone marrow and dosage units therefor
US5106863A (en) 1990-03-26 1992-04-21 Ortho Pharmaceutical Corporation Substituted imidazole and pyridine derivatives
US5135934A (en) 1990-07-06 1992-08-04 Du Pont Merck Pharmaceutical Company 3-phenyl-5,6-dihydrobenz(c) acridine-7-carboxylic acids and related compounds as immunosuppressive agents
US5126351A (en) 1991-01-24 1992-06-30 Glaxo Inc. Antitumor compounds
US5223506A (en) 1991-06-04 1993-06-29 Glaxo Inc. Cyclic antitumor compounds
US5428040A (en) 1993-08-31 1995-06-27 The Du Pont Merck Pharmaceutical Company Carbocyclic fused-ring quinolinecarboxylic acids useful as immunosuppressive agents
EP0721942B1 (en) 1993-09-28 2002-06-05 Kyowa Hakko Kogyo Co., Ltd. Tetracyclic compound
US5807874A (en) 1995-05-17 1998-09-15 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
US5767142A (en) 1996-03-20 1998-06-16 Rutgers, The State University Of New Jersey Trisbenzimidazoles useful as topoisomerase I inhibitors
PL324034A1 (en) 1995-05-17 1998-05-11 Univ Rutgers Tribenzimidazoles useful as inhibitors of topoisomerase i
DE69705112T2 (de) 1996-02-12 2002-03-21 Rutgers, The State University Of New Jersey Coralynanaloge als topoisomerase inhibitoren
US5770617A (en) 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
JP2001501197A (ja) 1996-09-23 2001-01-30 ルトガーズ，ザ ステイト ユニバーシティ オブ ニュージャージー 抗―腫瘍剤としての置換された複素環式化合物類
US6140328A (en) 1997-12-12 2000-10-31 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
JP4580556B2 (ja) 1998-10-14 2010-11-17 パーデュー リサーチ ファウンデイション 抗腫瘍薬である新規インデノイソキノリン類
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
CA2389312A1 (en) 1999-10-29 2001-05-10 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
DE60225943T2 (de) 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase-giftmittel
ES2340473T3 (es) 2001-11-14 2010-06-04 Rutgers, The State University Venenos de topoisomerasas solubilizadas.
CA2467279A1 (en) 2001-11-14 2003-06-26 Edmond J. Lavoie Solubilized topoisomerase poison agents
WO2003041653A2 (en) 2001-11-14 2003-05-22 Rutgers, The State University Cytotoxic agents
WO2004014918A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted topoisomerase agents
CA2510337C (en) * 2002-11-12 2013-01-08 Rutgers, The State University Of New Jersey Topoisomerase-targeting agents
TW201038578A (en) * 2009-01-30 2010-11-01 Univ Rutgers Methods to treat cancer
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer

Also Published As

Publication number Publication date
US20120101117A1 (en) 2012-04-26
WO2010102219A1 (en) 2010-09-10
JP5773888B2 (ja) 2015-09-02
EP2403856B1 (en) 2012-12-19
US10179789B2 (en) 2019-01-15
US9562051B2 (en) 2017-02-07
EP2403856A1 (en) 2012-01-11
ES2401563T3 (es) 2013-04-22
DK2403856T3 (da) 2013-04-08
US20170355706A1 (en) 2017-12-14
JP2012519705A (ja) 2012-08-30

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