PL324034A1 - Tribenzimidazoles useful as inhibitors of topoisomerase i - Google Patents

Tribenzimidazoles useful as inhibitors of topoisomerase i

Info

Publication number
PL324034A1
PL324034A1 PL96324034A PL32403496A PL324034A1 PL 324034 A1 PL324034 A1 PL 324034A1 PL 96324034 A PL96324034 A PL 96324034A PL 32403496 A PL32403496 A PL 32403496A PL 324034 A1 PL324034 A1 PL 324034A1
Authority
PL
Poland
Prior art keywords
tribenzimidazoles
topoisomerase
inhibitors
useful
tribenzimidazoles useful
Prior art date
Application number
PL96324034A
Inventor
Edmond J Lavoie
Leroy Fong Liu
Qun Sun
Original Assignee
Univ Rutgers
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from US08/442,657 external-priority patent/US5807874A/en
Priority claimed from US08/618,988 external-priority patent/US5767142A/en
Application filed by Univ Rutgers filed Critical Univ Rutgers
Publication of PL324034A1 publication Critical patent/PL324034A1/en

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D235/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings
    • C07D235/02—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, condensed with other rings condensed with carbocyclic rings or ring systems
    • C07D235/04—Benzimidazoles; Hydrogenated benzimidazoles
    • C07D235/18—Benzimidazoles; Hydrogenated benzimidazoles with aryl radicals directly attached in position 2
PL96324034A 1995-05-17 1996-05-14 Tribenzimidazoles useful as inhibitors of topoisomerase i PL324034A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US08/442,657 US5807874A (en) 1995-05-17 1995-05-17 Trisbenzimidazoles useful as topoisomerase I inhibitors
US08/618,988 US5767142A (en) 1996-03-20 1996-03-20 Trisbenzimidazoles useful as topoisomerase I inhibitors
PCT/US1996/006853 WO1996036612A1 (en) 1995-05-17 1996-05-14 Tribenzimidazoles useful as topoisomerase i inhibitors

Publications (1)

Publication Number Publication Date
PL324034A1 true PL324034A1 (en) 1998-05-11

Family

ID=27033238

Family Applications (1)

Application Number Title Priority Date Filing Date
PL96324034A PL324034A1 (en) 1995-05-17 1996-05-14 Tribenzimidazoles useful as inhibitors of topoisomerase i

Country Status (10)

Country Link
EP (1) EP0839140A1 (en)
JP (1) JPH11508229A (en)
AU (1) AU713317B2 (en)
BR (1) BR9608476A (en)
CA (1) CA2221248A1 (en)
CZ (1) CZ363197A3 (en)
HU (1) HUP9900071A3 (en)
NZ (1) NZ307959A (en)
PL (1) PL324034A1 (en)
WO (1) WO1996036612A1 (en)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5770617A (en) * 1996-03-20 1998-06-23 Rutgers, The State University Of New Jersey Terbenzimidazoles useful as antifungal agents
DE69839781D1 (en) 1997-12-31 2008-09-04 Univ Rutgers Heterocyclische topoisomerase toxine
IL137351A0 (en) 1998-02-12 2001-07-24 Univ Rutgers Heterocyclic topoisomerase poisons
US6833373B1 (en) 1998-12-23 2004-12-21 G.D. Searle & Co. Method of using an integrin antagonist and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6858598B1 (en) 1998-12-23 2005-02-22 G. D. Searle & Co. Method of using a matrix metalloproteinase inhibitor and one or more antineoplastic agents as a combination therapy in the treatment of neoplasia
US6740650B2 (en) 1999-10-29 2004-05-25 Rutgers, The State University Of New Jersey Heterocyclic cytotoxic agents
AU2002365161B2 (en) 2001-11-14 2008-07-03 Rutgers, The State University Solubilized topoisomerase poison agents
DE60225943T2 (en) 2001-11-14 2009-01-29 Rutgers, The State University Topoisomerase GIFT FUNDS
EP1465625B1 (en) 2001-11-14 2010-02-03 Rutgers, The State University Solubilized topoisomerase poisons
DE60228484D1 (en) 2001-11-14 2008-10-02 Univ Rutgers CYTOTOXIC AGENTS
US6992089B2 (en) 2002-08-09 2006-01-31 Rutgers, The University Of New Jersey Nitro and amino substituted topoisomerase agents
US6989387B2 (en) 2002-08-09 2006-01-24 Rutgers, The State University Of New Jersey Nitro and amino substituted topoisomerase agents
WO2004014862A1 (en) 2002-08-09 2004-02-19 Rutgers, The State University Nitro and amino substituted heterocycles as topoisomerase i targeting agents
JP4774212B2 (en) 2002-11-12 2011-09-14 ラトガーズ、ザ・ステイト・ユニバーシテイ・オブ・ニユー・ジヤージー Topoisomerase-targeting agent
WO2010102219A1 (en) 2009-03-06 2010-09-10 Rutgers, The State University Of New Jersey Methylenedioxybenzo [i] phenanthridine derivatives used to treat cancer
WO2010127363A1 (en) 2009-05-01 2010-11-04 Rutgers, The State University Of New Jersey Toposiomerase inhibitors
US11091498B2 (en) 2016-04-04 2021-08-17 Rutgers, The State University Of New Jersey Topoisomerase poisons

Also Published As

Publication number Publication date
MX9708822A (en) 1998-06-30
BR9608476A (en) 1999-08-17
HUP9900071A3 (en) 2002-01-28
JPH11508229A (en) 1999-07-21
AU5746696A (en) 1996-11-29
AU713317B2 (en) 1999-11-25
HUP9900071A2 (en) 2000-03-28
CZ363197A3 (en) 1998-05-13
EP0839140A1 (en) 1998-05-06
CA2221248A1 (en) 1996-11-21
WO1996036612A1 (en) 1996-11-21
NZ307959A (en) 1998-08-26

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